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<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJR2</accession>
    <name>D6SJR2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module killer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3567"/>
    <dbReference type="EnsemblBacteria" id="EFI36115">
        <property type="protein sequence ID" value="EFI36115"/>
        <property type="gene ID" value="Dthio_PD3567"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="117" mass="13104" checksum="1B875DED50799035" modified="2010-08-10" version="1">MYIFLRTQEFDNWLKRLRDPLGKARIIARIRSAEAGNFGDCESVGKRVSEVRISYGPGVTIQGGPRWWQVAGNCPLNGYVRAIGFISQEKGGLCIFCCAVAIIRAKKKTSRKPVSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJT5</accession>
    <name>D6SJT5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869263.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3592"/>
    <dbReference type="EnsemblBacteria" id="EFI36138">
        <property type="protein sequence ID" value="EFI36138"/>
        <property type="gene ID" value="Dthio_PD3592"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2102149at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9605" checksum="E8171E885AD25198" modified="2010-08-10" version="1">MEELFLSASVIIVLLIVLLALLIAILIAPLLIWRNTNRTNRLLVLIALQSGVPPKHVKEVYRMPGSDMSSVFNKLEIDNDFSFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJV6</accession>
    <name>D6SJV6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36159">
        <property type="protein sequence ID" value="EFI36159"/>
        <property type="gene ID" value="Dthio_PD3615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="9100" checksum="1BCFBB3341E4FCE8" modified="2010-08-10" version="1">MVLLKFIWVLLYLVGAYLDYQTHTFSYLDSLIAVFPAFIVGLVPATLVYFFFMKSKWSWHHVLNLATGIMVVWIIITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK03</accession>
    <name>D6SK03_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869328.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36206">
        <property type="protein sequence ID" value="EFI36206"/>
        <property type="gene ID" value="Dthio_PD3663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088083" evidence="2">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9639" checksum="5480E2827D8B0FCE" modified="2010-08-10" version="1">MFEKMGIKLLSLLFAFMLVMGFGMNLHAADGFDAEEPAAEEYGGAEGHEAPEGYEEYEPEEYEEYEAPEGYEEHEPEEYEEPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK17</accession>
    <name>D6SK17_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CheX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869342.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3677"/>
    <dbReference type="EnsemblBacteria" id="EFI36220">
        <property type="protein sequence ID" value="EFI36220"/>
        <property type="gene ID" value="Dthio_PD3677"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2054951at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="176" mass="19599" checksum="37D80C549CC1097D" modified="2010-08-10" version="1">MQEQSVNIKDLMQSLAQGTQSFLQSEAGVSVTGIDCRYEPVNTLKLSYLTSLISVNSSINMFFAFSFEKDLIFSILRQMTQGLDYPEEETPDYLESAATEMLNIVVGNTAEFFAPGGERVTFSPPIVIQEARNMIRTQGTTFYSSVVQTSKGNLYIHLIGPRQLFDEQLNNLEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK43</accession>
    <name>D6SK43_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36246">
        <property type="protein sequence ID" value="EFI36246"/>
        <property type="gene ID" value="Dthio_PD3703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13292" checksum="42F3935AACDCA5BC" modified="2010-08-10" version="1">MHESPMYSPNHNQNAFTLIEILLIITIIGLLTAIAIPWYASYRDSTRKATIIHDLRICLSETAVDIHNGDAPSPCHIGANANYDKNPFADEAGMLSPSPDFEVAGYFFEFDGRRIHTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK95</accession>
    <name>D6SK95_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide binding protein PINc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869417.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3761"/>
    <dbReference type="EnsemblBacteria" id="EFI36298">
        <property type="protein sequence ID" value="EFI36298"/>
        <property type="gene ID" value="Dthio_PD3761"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="141" mass="15989" checksum="E9F3099D8A2E2D4F" modified="2010-08-10" version="1">MSGKKTYKVVIDTNVFVSSFFGGLPRQTIDLWKNGQIILCLSQDIVEEYMEVLIRLGVTDKKSLEDLSGLFARGWNCLYAGVTPDLSVIQEDSGDDKFLECAIALDAGFIISGDQHLKKLKKYFHIRIMSPREFMDFLNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKA4</accession>
    <name>D6SKA4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869426.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3771"/>
    <dbReference type="EnsemblBacteria" id="EFI36307">
        <property type="protein sequence ID" value="EFI36307"/>
        <property type="gene ID" value="Dthio_PD3771"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1628" mass="188195" checksum="6C7235480C62C2E3" modified="2010-08-10" version="1">MPLDLTGISNENEFYTHHYLTAILENDLKDLFKEWNRRQKEEKIPTPASIISGLSRDYFRLRNDLFQAKDPGARQLIQEEFLEKLISALGYPFEPGTGEGPGGRQFPIAGEIQKGSGAPELWILPVMDEFGREEVDPLELSPLPGQFCSPSNDHNSRPCESRPGAAWISSTPEDRDKHSPDTHDTLSSNENDAACSDLDWQTLLTKSVFAREEPPRWVILAGTSQILLLDRAKWPQKRLLRFDLNDILGRREDSTLKAMAALLHRESVCPRDGIPLLDTLEENSHKHAYAVSEDLKYALRECIELLGNEAVWYLRHKLHQRLFSGDEDLDPAWLSKECLRYMYRLLFLFYIEARPDLGYVPMQSGAYRSGYSLESLRELEMVPLTSTESQEGYYIHDSLQLLFELVYNGYPQAGSAKEQQQMMQDESLHNTFCIPPLRSHLFDQERTPILKKVKIRNKVLQRIIRLMSLTREARGRNQRRGRISYAQLGINQLGAVYEGLLSYRGFFVQNEGGLYEVKKSGEAWNTLDIAYFVKEDELPEYSQDELVYNQDGSLTHYTKGTFIYRMSGRDRQQSASYYTPESLTQCLVKYSLQELLQGKKADDILELTICEPAMGSAAFLNEAVNQLAQAYLDRKQNELDTRLSVEELAREKQKVKTYLADNNVFGVDLNPVAVELAEVSLWLNTIYAGGYVPWFGNQLVCGNSLVGARRDVFQPNLLRKKSKSDPLWLDSVPERIQPGARRPRGTVYHFLLPDKNMAAYSDKNVKKLVPDSFQALKEWKKNFTRPFSQEDIKQLQKLSQAVDELWAEHVARQRRLRQSTRDPLSFFGHAMEEKDQTPVRNKDRILRQEQWAEGLRHSTPFKRLKLAMDYWCALWFWPLEQTDLLPSREAFLLEMSLILQGEVYEATNVTDKHGRPRMPGIEIPEQQAKPAADENLGRVNVDGLCDKLERLKLARDLAEKYRFLHWELEFADIIEDRGGFDLILGNPPWIKVQWEEGEVMGDHEPLFVLRKKSAPELARLREQTLEKLNLTPSYLQAYEESEGTQMFLNARQNYPALHRMQSNLYKCFLPQAWRYGKQNGVSGFLHPEGVYDDPKGGRLREEIYPRLRYHFQFVNELKLFSDIDHHNSFSVNIYRYWGDTVSFIHTANLYVPKTVDNCFEHSGHGQIPGIKDEHNKWNVHGHASRLIPVTEKELQLFARLYDPEGTPALQARLPAIHSKELVQVLEKFAAQPIKLGDMQGEYFSTEMWHETNSQNDGTIRRDTQFPDTAEEWVLSGPHFFVGNPFYKTPRAECTKNADYDILDLTDLPDDYLPRTNYVPNCSQEEYHRRTPKVPWDGRPVTDYYRLAYRGMIGPSAERTLVGSIVTKNVGHTHGVQTTAFIASQQLVTSAAYGMSLTADFFVKTTGRSNLHFTWYNFPIFDSSDKILLFGLTLSCLTNHYASLWSSCWQDSFTADSWAKSDPRLPDSFFRSLRPKWHRDCALRTDYARRQALVEIDVLTAQALGMTLEELKTIYRVQFPVMRQYEADTWYDQNGRIAFTNSKGLTGVGFSRPEWNELTQETKNDQGRIIRISKSGRPLTRTFTDNTLPTGPYEKTMEYLPPFDKCDREEDYEVVWEEFERRFQDNYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKP9</accession>
    <name>D6SKP9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="4">2.4.2.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thi4</name>
        <name evidence="5" type="ORF">Dthio_PD2671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:55704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.59" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868393.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2671"/>
    <dbReference type="EnsemblBacteria" id="EFI35260">
        <property type="protein sequence ID" value="EFI35260"/>
        <property type="gene ID" value="Dthio_PD2671"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1025532at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00304">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022828">
        <property type="entry name" value="Thi4_prok"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00292">
        <property type="entry name" value="TIGR00292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="55"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <note>ligand shared between two adjacent protomers</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>ligand shared between two adjacent protomers</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>glycine</name>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="27922" checksum="20CDC51559644258" modified="2010-08-10" version="1">MALDEIIISRAIIETYTKKLMDSLELDVAICGAGPSGMVAAYYLASAGKKTAVFERNLAPGGGMWGGGMMFNEVVVQEEAREILDELDIKSVEYTPGYYTADSVEAVCTLGSKAAKAGARFFNLVCIEDVMIRENRITGLVINWSAVESAGLHVDPLTVRADYVVEATGHPVEIMQVIESKMDTRLNTPSGRLEGEKSMWAEKAEEHTIENTTEAFPGVYVCGMSANATFGSFRMGPVFGGMLRSGKKVAQEIINKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL63</accession>
    <name>D6SL63_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2844"/>
    <dbReference type="EnsemblBacteria" id="EFI35424">
        <property type="protein sequence ID" value="EFI35424"/>
        <property type="gene ID" value="Dthio_PD2844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="45" mass="5246" checksum="9AEA240776C1CA76" modified="2010-08-10" version="1">MGCDCQKCEFPQKLKDRPEDCTPEQIRECHGESKEQETTDKNQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLC4</accession>
    <name>D6SLC4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C39 bacteriocin processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868617.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2908"/>
    <dbReference type="EnsemblBacteria" id="EFI35485">
        <property type="protein sequence ID" value="EFI35485"/>
        <property type="gene ID" value="Dthio_PD2908"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088228" evidence="1">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="2">
        <location>
            <begin position="46"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="181" mass="20022" checksum="8051A0B3016A16CA" modified="2010-08-10" version="1">MSSKFKYAFAALLVLLLCSCSPFKSAPESLRQKEDVVWLEVPYVSQARDNDCGPAALASVLKYHGVEVSLEKISDEIYISSIGRTLLPDMENHARSKGLETMSGRGTVAQLKQAIDAGKPVIVLMDAGPALARRGHYIVITGYTSDGFLAHAGVERDVYISFNDLDEKWQSMNRLYLMVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLD3</accession>
    <name>D6SLD3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868626.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2917"/>
    <dbReference type="EnsemblBacteria" id="EFI35494">
        <property type="protein sequence ID" value="EFI35494"/>
        <property type="gene ID" value="Dthio_PD2917"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2021322at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="107" mass="11706" checksum="EA846ECC77E9AC88" modified="2010-08-10" version="1">MLMIRAIVRPEKTTEVMQSLLDAGYPALTKVEVAGRGKQRGLKLGEVIYDELPKEMIMTVIPDADKEFVTRAILDSARTGKGSFGDGKIFISPVDEVYTVSSGVKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLI3</accession>
    <name>D6SLI3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868676.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2968"/>
    <dbReference type="EnsemblBacteria" id="EFI35544">
        <property type="protein sequence ID" value="EFI35544"/>
        <property type="gene ID" value="Dthio_PD2968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="234" mass="25041" checksum="AA73D8B0838E54B4" modified="2010-08-10" version="1">MFNKTLFQWVTIIFLVVALAIPTQVLACGGGGGGGGGGNGGNGISESELRDALSDFPPEEIEEIIRSVNEWNEKYDFGDMQTMQENEARQREFEQMMRDQEQAQRDLRIAEGHYTLINIGNGIRTVGGWVVGGLVTYKTAGAPLWAPVLIGATTGAAGELGNQMAGYETEYINSTLTGAGRGLLTGSLPDGVGDATGIAMDVYDMVPEVENNSLSNTAPVSRGYSVEHFNPIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLU0</accession>
    <name>D6SLU0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3080"/>
    <dbReference type="EnsemblBacteria" id="EFI35651">
        <property type="protein sequence ID" value="EFI35651"/>
        <property type="gene ID" value="Dthio_PD3080"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034A6W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025500">
        <property type="entry name" value="DUF4390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14334">
        <property type="entry name" value="DUF4390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="189" mass="22656" checksum="AF1E4713C1DB25C8" modified="2010-08-10" version="1">MYRSLFKYILVFFVFTGMSFLHVYESRAQPLDFSSFLIDTQEDYLVAMFSIDIEEFEKIQKALHDGNKISMICTIKLKRHRTLFWNKNIQEKTIEVDMAKDLLSEEYMIKFPDKTYTLKKLQEDSFDALFENISIKLAPLEELMPQRDYKLHIGIRVISKDVPQWIKSTLFFLSWDVVPEVRYEKEFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLX8</accession>
    <name>D6SLX8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="4" type="ORF">Dthio_PD3118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868818.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3118"/>
    <dbReference type="EnsemblBacteria" id="EFI35689">
        <property type="protein sequence ID" value="EFI35689"/>
        <property type="gene ID" value="Dthio_PD3118"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="143460at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="8"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="608" mass="68219" checksum="86C20F8BA1520307" modified="2010-08-10" version="1">MKEIRQNDSIRNIAIIAHVDHGKTTLVDGMFRQSGVFRQGLEVEERIMDSMDLERERGITISAKNCAVMWKGVKINIIDTPGHADFGGEVERSLSMADGAVLLVDASEGPLPQTRFVLKKTLEAGLKIIVAINKIDRKDARPAEVLDEIYDLFIDLDAGEEQLDFPVIYCMALDGIARKDFHEDSDNLDILFDTILDFIPPPSFEPDKPFQMLVSDLGYSDYVGRLAVGRVFNGRARQSDQLVRLGPEGSQDMLRVTKLQTYAGQELVEISEIQAGDIAVISGIEEVHIGDTICTRDNPMAMQRITVDEPTVSMKFSINTSPMAGKEGKYVQSSKIWERLQKETLSNVAIQVEKTRDKDSFVVKGRGEFQMAILIETMRREGFELSVGRPQVIIRYQGDKKLEPMEHLFIDCDEAFMGVVTEKLSLRKGRMTNLVNHDTGRIRIEFTVPSRGLIGYRDEFLTDTKGTGIMNSYFTGYQEYRGDFPSRFMGSLVADRPGTAVPYALSNLKARGNLFITPGTQVYEGMVVGEHNREHDLNVNVCKEKKLSNVRAAGKDDAIVLPPVLPMTLERALHFIREDELVEVTPVSIRLRKTILSASQRHSARPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM06</accession>
    <name>D6SM06_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheW protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868846.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3146"/>
    <dbReference type="EnsemblBacteria" id="EFI35717">
        <property type="protein sequence ID" value="EFI35717"/>
        <property type="gene ID" value="Dthio_PD3146"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="158" mass="17698" checksum="005A23998DCEA74D" modified="2010-08-10" version="1">MENHTQKKDADLLQMVTFNIGGEEFGVEILTVQEIIRMMQITKVPKAPDFVEGVINLRGKVIPVIDLRKRFGLDSRGHDKNTRIVVVEINKMIVGFIVDSVSEVLRIPADTVEPPPPVVAGLDSEYISGVGKLEDRLLILLDLDRLLSREEKKVLSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMH3</accession>
    <name>D6SMH3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869013.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3323"/>
    <dbReference type="EnsemblBacteria" id="EFI35884">
        <property type="protein sequence ID" value="EFI35884"/>
        <property type="gene ID" value="Dthio_PD3323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="154" mass="17623" checksum="AD86098C3D056A9C" modified="2010-08-10" version="1">MYQRILVPVDLQEEDERLRNLALQNAVELCRFYNARLYVLTVVPDLGMPVVGNYFPQDVSSQIVREAENLLHEHVTSHLPQDLDIQHIVAQGTVYRRILKTARQVNADLIVIPAHRPTLTEYFIGSNTSRVVRYAGCSVLVVRSELDQNIICVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMH5</accession>
    <name>D6SMH5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869015.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3325"/>
    <dbReference type="EnsemblBacteria" id="EFI35886">
        <property type="protein sequence ID" value="EFI35886"/>
        <property type="gene ID" value="Dthio_PD3325"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033JWE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1833313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027588">
        <property type="entry name" value="XXXCH_dom_fam"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04358">
        <property type="entry name" value="XXXCH_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="237" mass="27065" checksum="F370E52010B71914" modified="2010-08-10" version="1">MSKGKKFSQSLSLEEASNFLAELSAALENREVVLQGEKIAWDSMRKLKCSFYPRGDNLTLKVSVEQTKPENESNGLPKKKKGRKNALKQLKAGAKLKRSELKKRVRTAFRGIMDTSVKDETQADEAGAAPVQPPGTAGPSRSKTGYKTLKKRMKKTFASILRNAANYQLPTQKEMDSFINDSQAMVEFPGYGDEYYQEYMDRVRQMQEAFRQNDPRELMHKAQEVNQLQKDCHKRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMQ1</accession>
    <name>D6SMQ1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869090.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3404"/>
    <dbReference type="EnsemblBacteria" id="EFI35962">
        <property type="protein sequence ID" value="EFI35962"/>
        <property type="gene ID" value="Dthio_PD3404"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011375at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="228" mass="26099" checksum="A6BB1F210F5C2F4F" modified="2010-08-10" version="1">MANKEKDQSTDQDLSLDQDELDTDRGREKVELDLDDAPFLEEEEEELEAGEDHQGSRDQGDDTHDEDQKAPVPWWKQKKTFAAGAAALLILLLVTGYFLVSPEDEPPPPDPAPREVVDDPIEEPEKDLSEIIVDMEPFMVEFEADNNIRFLKARFSLSVLGDDMAREVQDKKLVLRDSIYYFLRNKDGSFLQNSANTDEITRDLMSVLEQYLGRDQLNNIVIEDYSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMU5</accession>
    <name>D6SMU5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GrpE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3448"/>
    <dbReference type="EnsemblBacteria" id="EFI36006">
        <property type="protein sequence ID" value="EFI36006"/>
        <property type="gene ID" value="Dthio_PD3448"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="188" mass="21766" checksum="265E3527DC720B05" modified="2010-08-10" version="1">MSIWSKLAGLFKTSPDRQEDTEEQEEQNDLQVIQEMIRNLQKRERRQAQNIERMLHELGARMDRLQAQMNAGLPMQAITSFTDSLSIYYLRNHESDQALNQVWSRYTALLQEMGIEPILDLKEKFDDTRHHACDTRQHPDYPENTILEVVRPGLMVSGRVTRPAVVVINKPGNGEPGHPEPSLHREQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMW2</accession>
    <name>D6SMW2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">Dthio_PD3465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869151.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3465"/>
    <dbReference type="EnsemblBacteria" id="EFI36023">
        <property type="protein sequence ID" value="EFI36023"/>
        <property type="gene ID" value="Dthio_PD3465"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1502854at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI36023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="207" mass="23459" checksum="144A4E4656041257" modified="2010-08-10" version="1">MNPKGILLVISAPSGAGKSTLIRMLCRDYPGFGFSVSYTTRKPRENEVHGKDYFFVQKDEFQGLIAKNFFAEWAEVHGNFYGTPARQVLESIQEGRSLIMDVDIQGARQIKNNLQQGAYIFIFPPSLDDLRQRLMHRGSDTAGAVEKRLQNAAGEMLKSDFFDYWLVNDDLDSSYARLKAIVLAEMQRPFIRPDLARKIASGVHYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMX1</accession>
    <name>D6SMX1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869160.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3474"/>
    <dbReference type="EnsemblBacteria" id="EFI36032">
        <property type="protein sequence ID" value="EFI36032"/>
        <property type="gene ID" value="Dthio_PD3474"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10472" checksum="06C5126CA6BC6065" modified="2010-08-10" version="1">MLMHNPPHPGEILRELCLEPLGLTVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFNTSAQSWLNQQSQYELWHAEQNRKKLRVKRLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN08</accession>
    <name>D6SN08_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein LpqB, GerMN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869197.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3514"/>
    <dbReference type="EnsemblBacteria" id="EFI36069">
        <property type="protein sequence ID" value="EFI36069"/>
        <property type="gene ID" value="Dthio_PD3514"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1101485at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Germane" evidence="1">
        <location>
            <begin position="54"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="164" mass="18052" checksum="FDAA7CCF5CEB8199" modified="2010-08-10" version="1">MRYLFILIFVAVVLAGCSEDKVVTSVDLYFMEITETRFKLASETRDFDGPQPGIKSVMEAWVEGPRSSELSRVVPEDVRLLDGFVRDSVAYVDFSTEITKAPMGGELEAVLVQSIVMTAAQVQGVNAVQIMVEGEIIESLAGHMLINRPIQITPSKNDNRPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNA7</accession>
    <name>D6SNA7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34233">
        <property type="protein sequence ID" value="EFI34233"/>
        <property type="gene ID" value="Dthio_PD1584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="177" mass="20428" checksum="D11CD479890064D2" modified="2010-08-10" version="1">MALSLFQAAHGLNRMSYKKACKLCLVDCTCKDMPSSLQHQEPLKPFDQYLWIIEGPFYYLDKYALQAGLGPDSAIPIIFRVHQDPFDQAWLTYPGIKCRRPENWLKVLALMYVNHVNFRLYQGEGREESPYSLTLLRPSIHEDLRVILGLAAQKKASELQKLENLLERAFSKLHDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNM8</accession>
    <name>D6SNM8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DsrE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869682.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1705"/>
    <dbReference type="EnsemblBacteria" id="EFI34354">
        <property type="protein sequence ID" value="EFI34354"/>
        <property type="gene ID" value="Dthio_PD1705"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1997912at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="121" mass="12705" checksum="56876B46BA395ABD" modified="2010-08-10" version="1">MAEKFCVTITHCRTDGDKATLGFVVANAAQGSEKETMIFLSCDGVYCAVKGEAEKIDEGTPFAPLKELVTKFVNAGGKIWVCTPCLKKRGLTEDDLVEGATPAGGAALVEWLASGSPSVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNN7</accession>
    <name>D6SNN7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH ubiquinone oxidoreductase 20 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869691.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1714"/>
    <dbReference type="EnsemblBacteria" id="EFI34363">
        <property type="protein sequence ID" value="EFI34363"/>
        <property type="gene ID" value="Dthio_PD1714"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="986649at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="4">
        <location>
            <begin position="15"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="328" mass="35871" checksum="EC90AB7CA8B364E4" modified="2010-08-10" version="1">MADKIKFGFLLAGGCAGCETALVDISERLVDALDHLEVVFWAPTVADVKYKDLEAMEDGYIDLAFVDGMVRNTENEHTVKVLRQKSKTLVAFGACASLGGIAALGDMHSKKELFDQAYKDTFSTDNPEGILPEPQCLWEGKYDLTLPAFTKRVSTIDQLVDVDYYVGGCPPHHDFIFQLIQAVVSGNLPPKGSWLTSGKAVCDVCKRNPAEHDQQRLPIGEVYRTVEGLPDEDKCLLQQGYICFGPVTQGDCQASCLNVNIPCRGCGGPIPGVRDYGARCVSMVASSLKDDQTAEKLIAKFNDMAKFCYRYSYSSGILNQKLTPGNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNY8</accession>
    <name>D6SNY8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="9" type="ORF">Dthio_PD1823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869786.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1823"/>
    <dbReference type="EnsemblBacteria" id="EFI34464">
        <property type="protein sequence ID" value="EFI34464"/>
        <property type="gene ID" value="Dthio_PD1823"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="417" mass="46044" checksum="BF8761BDD88F5C08" modified="2010-08-10" version="1">MANKKKKPYVSDLGCSFCGKTQDEVDRLIAGPDVYICNECVSLCDEIIAQDHAEETEEGDTLLPPSELKKALDDYVVGQEKTKKLLAVAVYNHYKRVRYIKKQKDDVELDKSNILLIGPTGSGKTLLAQTLARVLKVPFAIADATTLTEAGYVGEDVENILVQLMQNADYDLEAASKGIIYVDEIDKIARKSDSPSITRDVSGEGVQQALLKIIEGTEANIPPKGGRKHPQQEFIRMDTSNILFIAGGAFIGMDKIVRERVQKGSMGFGAELGSQFGATPNELISMAHPADLIKYGLIPEFVGRIPVVSSLEELTEDDLVRILTEPKNALVKQYQKMFELDDINLKFTQNALRAIAAKALERKTGARGLRNVMESIMMDVMYNLPSLQGVQECLINKEVVEKGIDPLLFYQQEAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP20</accession>
    <name>D6SP20_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869818.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1855"/>
    <dbReference type="EnsemblBacteria" id="EFI34496">
        <property type="protein sequence ID" value="EFI34496"/>
        <property type="gene ID" value="Dthio_PD1855"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="316"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="463" mass="53815" checksum="8C2D4E4482DFF397" modified="2010-08-10" version="1">MSFFIGRKKEIQFLEDEFAQDRASLVILYGRRRIGKTTLIKQFIQEKNAFYFVATEESERENRRNFQHAVSDFTHNTLLKKDVLLEWDEIFSVLNEHQPEKKKIIAIDEFQYLGKARTSFPSIFQRIWDQMLAGSRSMVILCGSLVGMMVEQALSYSSPLYGRRTGQIRLDQISYQDYGLFFKHPERINLIEYYAVTGGVPRYIELFTPATDIFQAIERNILSRQSFLFEEPVFLLEKEFGETGTYFSLVKTIAAGNRKLGRISSALGMNQSGLTKYLKTLQELDLIVREVPITEKNPEKSKKGLYRITDNFISFWFRFVHPYRSYLEIENTEVVIKKIKDQFRSSHVSCVYEDICRQWLMQKGLVKSPHIQLIQAGRWWDKDVEIDLLGVTENREHAVFGECKYTAAPVDADVYRQLMEKAQSVSLPDGSEKHYVFFSQSGFTEAMVDLARSQDNVHLASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP39</accession>
    <name>D6SP39_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869836.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1880"/>
    <dbReference type="EnsemblBacteria" id="EFI34515">
        <property type="protein sequence ID" value="EFI34515"/>
        <property type="gene ID" value="Dthio_PD1880"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10291" checksum="DC7438298A052836" modified="2010-08-10" version="1">MDDLDKYIEKRKKKSPSFGENFDKGYEQFKIGVLLKQARLEAGLTQEQVASILNTKKSAISRIENHAEDIRLSTLVNYAQAVGKNLHLKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP43</accession>
    <name>D6SP43_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase orf1 for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869840.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1885"/>
    <dbReference type="EnsemblBacteria" id="EFI34519">
        <property type="protein sequence ID" value="EFI34519"/>
        <property type="gene ID" value="Dthio_PD1885"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2088406at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="113" mass="13285" checksum="9DFEF7C259716652" modified="2010-08-10" version="1">MQTKSQKYTPEERAGFWSAHINKWRQGSLTKAEYCRRAELSKHAFYYWCKKLGHTYSRKTLEENAVVPVPLKVVQEKTHTPLRLMVNSYQVDIPGDFQQEVLAKLVRTLEEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPB2</accession>
    <name>D6SPB2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Substrate-binding region of ABC-type glycine betaine transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869908.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1960"/>
    <dbReference type="EnsemblBacteria" id="EFI34588">
        <property type="protein sequence ID" value="EFI34588"/>
        <property type="gene ID" value="Dthio_PD1960"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="770506at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088134" evidence="2">
        <location>
            <begin position="26"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="28"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="283" mass="31319" checksum="2968ACB58E7918D9" modified="2010-08-10" version="1">MIKKGLAVLSVLALLMGFASSNAGAQDRLTLAYVEWDCAVASTDVAKAVLQEELGYNVESMSVSAAAMWQGVASGDVDAHVAAWLPVTHGDYMDATEGQLEDLGKLTDGAKIGLVVPEYVDIDSIEDLNDYADEFNGRITGIDPGAGIMSRTEEALDEYGLTEFELQEGSDATMSAALRDATRRDEWIVVTGWSPHWKFGRWDLKYLEDPKEVYGEAEHISKMARQGLADDAPEAYEFLKNFSWTQEEMAVLMEWNEDGGDSYENAVRFIEEHPDLVDQWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPC5</accession>
    <name>D6SPC5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869921.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1973"/>
    <dbReference type="EnsemblBacteria" id="EFI34601">
        <property type="protein sequence ID" value="EFI34601"/>
        <property type="gene ID" value="Dthio_PD1973"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926903at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="14113" checksum="54044231397BFE46" modified="2010-08-10" version="1">MPYNWGPNFIVPTDVLESYSGKVLLREDLDKELLRQELSELGIQGSVVQIANPWYFRKKGHNSWIKIGESRDEAGNFPVRWDTTHLENGRYEVMGFMHVYVEKEGIQTVIARSNTVEISIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPG3</accession>
    <name>D6SPG3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869959.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2011"/>
    <dbReference type="EnsemblBacteria" id="EFI34639">
        <property type="protein sequence ID" value="EFI34639"/>
        <property type="gene ID" value="Dthio_PD2011"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="375" mass="41011" checksum="DD7CCFAEE8D72D95" modified="2010-08-10" version="1">MNIPVSPEKDHPSCILCGRCLEVCPLFKVTAHEEMSPRGKAFLVQHFSSKDISLKEASKLAGLCAGCNRCTTVCPQGIDLPRLISSLKSRHPGWKNWLFSRMLTNGAFFLPLINLGGRLLPQGGSAKVFSPPRSSITPLFKTRVSRKHSGRAVIFPGCFGRYLRRNLTEKAVHILGSTGMEILPTPAWKCCGFPLGQAGFLQEKQACMQANIKMWQELGRPRVYTFCATCRAGLTSDDSPEQLSAAMRMLARHTFSLSSILPDLSIEPLSHAGPQQFIWHEPCHGAQATAPALQEILGAENHGLKVPAGQCCGLGGAFRLQSPRLSLQVAHDLWEHLSPQASDLCLTECAGCMMQLASTAPRGTKTAHWLDLFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPK7</accession>
    <name>D6SPK7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870003.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2055"/>
    <dbReference type="EnsemblBacteria" id="EFI34683">
        <property type="protein sequence ID" value="EFI34683"/>
        <property type="gene ID" value="Dthio_PD2055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="315" mass="35440" checksum="49A8D5F80BFEB965" modified="2010-08-10" version="1">MDIVRLFKSLGDETRLRLLHLLLHHELNVNELVRIMDMGQSRISRHLKILADSGLLQSRRDGSYIYYTRAGGADLAHLTDFIIQAGGSRQDFAADLEKTQELLDERKHRVKTFFNSLVDDWDLLKQEVLGDFSLKRIVAREAQGANTAADLGCGTGEMLLELGRHAQRVIGVDSSAGMLEKSRQRLSGSGVNADLRLGELEHLPIRNGETDLVVMEMVLRHVAVPLEGIKEVSRVLEPGGRFIMADFDRHDQEEIRYRYGGVWAGFDREQLRQWLQQAGLDLLQLEQHWVQQGLGVNVCLAVKPQGPSGKEVFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPM6</accession>
    <name>D6SPM6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2074"/>
    <dbReference type="EnsemblBacteria" id="EFI34702">
        <property type="protein sequence ID" value="EFI34702"/>
        <property type="gene ID" value="Dthio_PD2074"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06325">
        <property type="entry name" value="PBP1_ABC_unchar_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="332" mass="36131" checksum="5DBCCBAA4BBCDA04" modified="2010-08-10" version="1">MNRIHLLSGLLFLLVNAVGLPEGLSSAWAQDFRVAILHSIRHPALDEAASGVIQHFQDKDVNIEFTQVFMNREQDEGKNEKDHISKISELDPNLVITLGTQASQEAVRKMESVDIVFSAVTDPVGAGLITDMHKPGGRVTGLTDMSPVREQLDMITWVHPGISTLGIVFSEFEQNAVLIKKRLQEMAGDSGLELLTAPVGPGGDVQDAALGILDRVQALYISTDNYVVQHVSMLARLCALHDVPLYAADPSSVAEGAMASLSIDYHSMGLQTGAMAKRILEGEKPGDISVEKPREVNITINTSSAEKMNVDLPLDLMLAADRVYDRFPEIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPR1</accession>
    <name>D6SPR1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34737">
        <property type="protein sequence ID" value="EFI34737"/>
        <property type="gene ID" value="Dthio_PD2110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="61" mass="7050" checksum="B2D2BCC156E2BA83" modified="2010-08-10" version="1">MSNRSLGYYLFLIGLLLLIAFPFLYFLQMLPAGSPAFYILVLILIFTLAAGYQDLKKIFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPV6</accession>
    <name>D6SPV6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870098.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34782">
        <property type="protein sequence ID" value="EFI34782"/>
        <property type="gene ID" value="Dthio_PD2159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="206" mass="24053" checksum="AA29433D19E6926C" modified="2010-08-10" version="1">MLDDSRYFRVRVSPSFCPENIELESFIFENNVENYAYEKNLEMIYENIDNFFDQKPDSYYYLNYDEVVALIISWFGIKSFNPILCNTVLQYLNIDSNEAFGVDDDFRERSAESASTILFQKKMSELGNDKGSNVYTQDAIDEFKKYSLSSRLTHAAVVVAFKIIQSPNFNELLQYIIVDARFALLYIQKKNAVFNKKKEDTSDLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPV8</accession>
    <name>D6SPV8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2161"/>
    <dbReference type="EnsemblBacteria" id="EFI34784">
        <property type="protein sequence ID" value="EFI34784"/>
        <property type="gene ID" value="Dthio_PD2161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="8138" checksum="171CD3412487A2FD" modified="2010-08-10" version="1">MQMAKLLLFMQSLDLIYFENKARKKARRCFFLEDPSRFRTRVVQNKKRKKELRPKVKCWKNELCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPW2</accession>
    <name>D6SPW2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870104.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2165"/>
    <dbReference type="EnsemblBacteria" id="EFI34788">
        <property type="protein sequence ID" value="EFI34788"/>
        <property type="gene ID" value="Dthio_PD2165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9107at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="102"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="812"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1483" mass="168683" checksum="8D3EB697BB4E648F" modified="2010-08-10" version="1">MIQEDILNNYSETALGVLQDYRRKLVQGLESEGLESEYISHVVQRFRISSDLYFSLQPEYRKCPESFSRYCSEKGLSPHLDRSLTSLHGHGFRLFEHQKKAVESILDNVPTVISAGTGSGKTECFLIPVLEHCLKSKDPGVKALLLYPMNALANDQMQRIAQLCRDTDVSYGLLTGATPEEPLPEKSIEDANRKYSRREITKSPPDILLTNYVMLERVLTTGKWHSLVESFAHSLKYVVLDELHTYQGSKAAHIMLLLRRLQRRLSGKALLIGSSATLSSPGRDSVDGQEREKELHNYVCTIFSVTRCNIITPEPEPPSSEISIEWPRKPGPDPELFSRPVSRKSLATMLKDLCGISLDGHEDLDSQVSDSSHPVERIARHPFMMALAQNLRDNGAMNLAEIIRIYRDICPYRLTSHEATEHVRAWLSLINCMNSFRLKKPILDLRLHMFMRALAGHLFFCLSCETYHPEGSGVCPDCSLPLFPSDKRNIHCCLAIAESGRLHPLEFQEFYEDSVCVQIRRYTHELEHETGILRCRIDFSAKNNDSTESLVFYQDAHGDYCLVLQEDRDKTSLNRLFVNLTERHKANDYLRSLIYHVLQYLPENKRKLLAFIDDREGVSHNSSVLRDEFAADFLEQLLVNLYPDATAQCSILQALNTLCRYPASPGSESMFTVQELEILDEAELWFLRFIKKPPDTSQGKKDFLMLRTVSSLSPVEQKILNVFLKERAIELFDIKAWKDSSYIKYNRHLAIRKRRIYLDAEQAPVSERITGISLSHYSRNHHAFLADLGRSVPADADSHLSVSEAARAGANIVRKIISSLVEKGIVREFSDDGRNSYALNPEYVVFSPEWINSRRTRAGSDPRAIIVRYHSSELETQKRADVENQFRKGDVDFLLATPTLEMGIDIGSLQSILLVGVPPCAANYAQRAGRAGRRGQLSLTICYCRDHLPHDVFYFHRPAEMINGLINPPTIHRPSSRLLLKHVRAELLSGYADGTGSMQEFAAMDQDLILQRLDGLSSVVDKNKMSFVEDYARNHFTDECREIFEKSRSFNLNPLNLMYQTGFLPDYGFHRDNVRVYEYDHYQKLAGSGRLSPMNRDHISEREPEQAVSKFAPGRTGYLAGDVYRFETTGRYQEWSIEAQTGRIEPPVRSYSIVTASKPEQVQKDNDPPIYLLNTMYNVSTSWKEFGNILQVTRDPQAKIAFMNFGCLNSQETVFKDKNGEFYLGYHLVRDALVMKIPREIFYSFELPISLLSALDRTIKNRYRLNDSEITSVTGLLPWQDLYTPFKKISHHHLAIYDSTGNSDLPLDKVAAEIEKVFIEAYARLRDCNYCIKNLTDGCYDCLKSFYTRHLARFASRGTAMNVLGYLAGKDRLTPDIQPYKKSGGANGADIDVRWKNRLLTISSAGKEPLTCGSCDAVTVYQSLAGAIQSWFPSGGQNLVITTNLDFLVKNINRQTQARTAGWELGRLRFELLRCDAVNIKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPX1</accession>
    <name>D6SPX1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870113.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2178"/>
    <dbReference type="EnsemblBacteria" id="EFI34797">
        <property type="protein sequence ID" value="EFI34797"/>
        <property type="gene ID" value="Dthio_PD2178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="231" mass="25950" checksum="7E5D99EB12EEEFE8" modified="2010-08-10" version="1">MEKPTKKSTIPALVLGGMLAYGTIGDKVNSEYQNTTQENAQVETAQTDYKASALENLTQALAPNKAFAQTNQNYQRPDDATLKKWMNDYSLQQVLQGTEYTKVNDNNYEREVKNANQPVMVLFHADPQDTTNSGGQTGLAALARVLNEKFPEIKFCTYQHSDGKTILRPAFERLQQNYPLESAPALLFYEEKDFGSGTEKGHAFNGGIKNFDLLTDTIESFYEPIKRNMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPY0</accession>
    <name>D6SPY0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2187"/>
    <dbReference type="EnsemblBacteria" id="EFI34806">
        <property type="protein sequence ID" value="EFI34806"/>
        <property type="gene ID" value="Dthio_PD2187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088144" evidence="1">
        <location>
            <begin position="23"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="372" mass="40888" checksum="4550E604D597B66D" modified="2010-08-10" version="1">MNIKLIIALFVSFLLITSLAIAPGGGEETQDPEDFTTAKEMMEHGEVPPGFDKELEFTTQEEFEFLVENGLNGRNTEDITLDNGYTINEGKFTMSWGEKALLAPGAITDENGNEIGGGEMDITEIMEGNIPSADELEHQTPEGDISSGQGLEGMNWQGSDYTIDYADYWETESHKIVEGHGIQKSGGNIYVDEGHAIDSDDEFVSYADSYESSGDEFSIGEAKAVLLDGTLFTDVKDSYFKTKDGAITEASVTSSTDDNSFTLDGITVEMDENDTFNAKLDEETGKFDLSLDSEQGKIEATYPNVGCVEISPGSRFEYTGSDFDDFALFVPSYGGVYELCIRTLPEENYTSDCSRCGVKDFVNKMRKIWGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ12</accession>
    <name>D6SQ12_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2229"/>
    <dbReference type="EnsemblBacteria" id="EFI34838">
        <property type="protein sequence ID" value="EFI34838"/>
        <property type="gene ID" value="Dthio_PD2229"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="261" mass="29253" checksum="D9464D23F45E3365" modified="2010-08-10" version="1">MHKSTQTKSRSCDRVRLLGLDFAANPDFVHLYLEPPSWDYTPGQFVMLRPEKWGQDPVWPRPFSICEKTREYVRIFMQVVGRGTSLLSSAAPDSEINMWGPLGRGFRLSPEKRYLILAGGMGIAPFIGLCKEHPYPGKLSLIFGHRMDRSCYPFDELPGEMQRQNMRQTNQEDMEHFGRVLREQISRFASRGEILACGPMPFLQVVQKHVLEAGASAQLSVETRMACGVGACLGCVVETRSQGLVQSCVQGPVFDAGELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ14</accession>
    <name>D6SQ14_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870154.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2231"/>
    <dbReference type="EnsemblBacteria" id="EFI34840">
        <property type="protein sequence ID" value="EFI34840"/>
        <property type="gene ID" value="Dthio_PD2231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="268"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="441" mass="50843" checksum="8B5FD932222097E4" modified="2010-08-10" version="1">MSQPIKEAAAVCKTIMRNGYDAYVINAPLQERAMDQDHMEVDICTELDFTGLTKLFPSLETSGGLDFLGSLRQGQVTFNFYPADVIESSYTDGTIARMTPRLVKRLEEMGDMPLTWACPYIPDPRAVYDGFEDLDTGKVTLEGLPDETLKKDYLRAIKALRFSANFGLPIEGNTWLAILRSSRRVLDYVSVTDLMDEWRKVEAENMHRFVSLLFESMILHGLIPELASLSRVKQVKNQEEGLENVWEHTLGVMRYYPEELPYDWYGTMACLFHDVGKLFAAEYFHDRITFYQHHRIGAKVARKILKRLRFNTDEIDLVCHLVRHHMRFHFMLTDRGIRRFMALDEYPRLMEMVRADIKARDGSYKEFNHNLKMLQKAKVSEDTLEPLLNGHEIMEFTGIKPGPGVGVIREALLQAQAAGDVTSVPEAIEFVMRYKEKEHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ71</accession>
    <name>D6SQ71_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavodoxin/nitric oxide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870211.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2288"/>
    <dbReference type="EnsemblBacteria" id="EFI34897">
        <property type="protein sequence ID" value="EFI34897"/>
        <property type="gene ID" value="Dthio_PD2288"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="6">
        <location>
            <begin position="253"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="400" mass="45062" checksum="1709BE2D21B36FF0" modified="2010-08-10" version="1">MPAIEIKKNVYWVGAIDWNLKNFHGYAMARRGTTYNAFLVLDDKITLFDTVSEKFKWDLYHQVRSLVKLEEIDYIVVNHLELDHSGALPFMVDNIKPEKIFCSSMGEKSIHGHFHNKDWPLQVVKDGESISLGKRNVTFMETRMLHWPDSMFSYIPEDKLLISSDAFGQNIASQKIFDDQHDLNLLLSEARHYYTNIILPFSPLVQKLLDKVQKAGLEIDMIAPDHGVIWRTHPGKILEAYADFAAQTLKPKAVLVYDTMWGSTEKMVKAVADALTEEGIDIRVMSLKSFHHSDVMGEFSDAAALVCASPTHNNGMLPLMSDFLTYMKGLKPKNRLGAALGSYGWSGEAPGAMAKVLEEAGFELPEKPYRTQFVPAHEQLAQCKELGRNLASAIKAKTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ86</accession>
    <name>D6SQ86_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870226.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2303"/>
    <dbReference type="EnsemblBacteria" id="EFI34912">
        <property type="protein sequence ID" value="EFI34912"/>
        <property type="gene ID" value="Dthio_PD2303"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045045">
        <property type="entry name" value="RTM2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670">
        <property type="entry name" value="PTHR43670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="137" mass="15647" checksum="DE1D6C528E8FC466" modified="2010-08-10" version="1">MVIDLSSFYNVPRQMDRFFDEIWKPSMISQRRNAYPPVNISEDVSNIYVHLEMPGVDIEDVDITLSDGSLVIKGNRKHDTGNYYRQERPAGLFQRVINLNVPVDADKVKARMKDGILDIVVPKAEEAKPKKVSIEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQG1</accession>
    <name>D6SQG1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">Dthio_PD2379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870301.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2379"/>
    <dbReference type="EnsemblBacteria" id="EFI34987">
        <property type="protein sequence ID" value="EFI34987"/>
        <property type="gene ID" value="Dthio_PD2379"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="169" mass="19475" checksum="0BB530F185149632" modified="2010-08-10" version="1">MSRKIHTYPDKILTQKARPVEKIDDYIIDLSRDMARLMYEHRGIGLAAPQVGESLRVVTVDLSGPDNQEDLFTYINPEIIASEDETTTEEGCLSVAGYQTRVCRARKVKVRALNLQGEEVIHEGEDLWAVCLQHEIDHLNGILFIDHISRLKRAMYDKKVKKWLENKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQJ8</accession>
    <name>D6SQJ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870338.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2418"/>
    <dbReference type="EnsemblBacteria" id="EFI35024">
        <property type="protein sequence ID" value="EFI35024"/>
        <property type="gene ID" value="Dthio_PD2418"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1718182at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="173" mass="19776" checksum="951450EB837EE314" modified="2010-08-10" version="1">MSRENFKNWVCKAVEMEEKGKAFYEQAAKECTTQMGQKIFSMLRDDEIQHIQRIREIEKALDQDSGLEQACCMDDMGSDAGQAFKELAEKVKSEKPCDSTAKALNAGIDFELALVKFYEEALEKASEDLERDFLKRMIQEEKGHYVLLSDMQYYYEDPEGWALGKARSGLDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQL3</accession>
    <name>D6SQL3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methionine biosynthesis protein MetW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870353.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2433"/>
    <dbReference type="EnsemblBacteria" id="EFI35039">
        <property type="protein sequence ID" value="EFI35039"/>
        <property type="gene ID" value="Dthio_PD2433"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010743">
        <property type="entry name" value="Methionine_synth_MetW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07021">
        <property type="entry name" value="MetW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02081">
        <property type="entry name" value="metW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="217" mass="25131" checksum="3CB4F01119806B39" modified="2010-08-10" version="1">MQASDDKVRFDWKRSLHRDRELDPYIMELAGTGERVLDLGCGRGELLKKLKEEKQVREQGIELNSEHVADCLAQGLSVIQADLEEGLNDFLGDCFDLVILNQVLLTVKNPLALLQQALRIGHRAVVTFPNFAHWRIRLHLLLTGRLPVNQTLPYKWYESPEIRLATIKDFQELCREMQVEIVSRRFLQLNYLVQNRKVNIWPNLRSTVALFCLRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQN1</accession>
    <name>D6SQN1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2451"/>
    <dbReference type="EnsemblBacteria" id="EFI35057">
        <property type="protein sequence ID" value="EFI35057"/>
        <property type="gene ID" value="Dthio_PD2451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030888">
        <property type="entry name" value="Put_ccm"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04391">
        <property type="entry name" value="CcmD_alt_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="42" mass="4893" checksum="D377CD17160A95A6" modified="2010-08-10" version="1">MTYLIASNVVVWLGIGGYLFFLAMGQKKLEKKIRQLEVMHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQN2</accession>
    <name>D6SQN2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870372.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2452"/>
    <dbReference type="EnsemblBacteria" id="EFI35058">
        <property type="protein sequence ID" value="EFI35058"/>
        <property type="gene ID" value="Dthio_PD2452"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1958850at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="22283" checksum="10C4C86C1CCCED79" modified="2010-08-10" version="1">MSSGLLSSISIRRAVVAFAMLGLAVIFLSSIWYRIDSPSLVEETQTRQADQQMMARIAGLMQEVEQNPENVEAITELAGFFMQNQDWDKALSFWRRALSVDPDNQLALNQAGFTLFQMQRHDEAREKFERLLELNPENHQGHFNLAIIYKYYLDEPEKAREHLEKIIEIDPDHPELLERVRQELETPAPGEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQR1</accession>
    <name>D6SQR1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase, alpha subunit</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870401.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2481"/>
    <dbReference type="EnsemblBacteria" id="EFI35087">
        <property type="protein sequence ID" value="EFI35087"/>
        <property type="gene ID" value="Dthio_PD2481"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1276859at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="218" mass="23606" checksum="FD70F7906C77E50F" modified="2010-08-10" version="1">MFTGLIQGTGRVAATEKKGLETRFTIRPGFVLSDPRPGESIAVNGVCLTAENFSRDAFHVYASAQTISVTSLKDLGTGSHVNLERALALGDRLGGHIVSGHVDCLARVEDIRADGESRRITLVFPEELSPQVIDKGSVALDGVSLTITGCGPGWLQVNIIPATWKETTLAGWKKGTQVNMETDLIGKYVQNMLGPWLEGRSRDQGGRLDMDFLRQHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQV8</accession>
    <name>D6SQV8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870448.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2529"/>
    <dbReference type="EnsemblBacteria" id="EFI35134">
        <property type="protein sequence ID" value="EFI35134"/>
        <property type="gene ID" value="Dthio_PD2529"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="336" mass="38611" checksum="6CF3966B6B5CFCF9" modified="2010-08-10" version="1">MTIDKDNMTQRKKERQDIKAPEEGQLDEKKVAEKLESAVGKEVSPLPGNTPMPMDALRIYLRQVGNFPTMSAEEEFELARKFRDEGNQDAAFMLITSNLRLVVKIAMEFQRKWMKNVLDLIQEGNVGLMKALKKFDPDKGIKFSYYASFWIRAYILKFIMDNWRMVKVGTTQAQRKLFYNLSKEKQRLESMGITADADAISQSLDVSETDVVEMGQRLGQHDLSLDMPYNEDSDVTPMNVIPALGDGAEEILLQGETAQLLQQNIKELMPKLSDKEKDIIEMRLLAESPVTLREIGEKYGITRERVRQIESRLLGKIKAHIQENIDDFSREWIEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQY4</accession>
    <name>D6SQY4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RarD protein, DMT superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35160">
        <property type="protein sequence ID" value="EFI35160"/>
        <property type="gene ID" value="Dthio_PD2558"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="311" mass="34441" checksum="7DED36681D3F3382" modified="2010-08-10" version="1">MHKTVSSAPLANRPDNSFSNSWGGLLAGMGAFTLWGILPVYWKGLSTVPAAEILCHRILWSFVFVAVFLTLSRRWPEVSSLLRSRKSVLLLGLSSLMLSINWLTYIWGVNAGFVIEASLGYYINPLVNVLLGCLVFRDRLRPLQVMAILLAAAGVLNIVFNYGQVPWIALVLAFTFAAYGLIRKVVRTESLPGLWLETAIISGPALIFLLLSPGRGSFAAMGLQIDILLIGAGLITSLPLLLFAFSARRLRLVEVGILQYIAPTMMFLLGLLVFKEPFSPARLISFIFIWAGIIIYMCESIWFLKKFSPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQZ9</accession>
    <name>D6SQZ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0402</name>
        <name evidence="3" type="ORF">Dthio_PD2573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870489.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0402"/>
    <dbReference type="EnsemblBacteria" id="EFI33087">
        <property type="protein sequence ID" value="EFI33087"/>
        <property type="gene ID" value="Dthio_PD0402"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35175">
        <property type="protein sequence ID" value="EFI35175"/>
        <property type="gene ID" value="Dthio_PD2573"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2090386at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8082" checksum="E732392652A2639F" modified="2010-08-10" version="1">MTTLTVRLPESMKNELDQLSRAENRAVSDIVRESLKRYIAVEKFRSVRGKILPFAEAQGLLTDEDVFKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR62</accession>
    <name>D6SR62_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870536.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33178">
        <property type="protein sequence ID" value="EFI33178"/>
        <property type="gene ID" value="Dthio_PD0502"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="35680" checksum="E2885D5343442999" modified="2010-08-10" version="1">MPRIARFIRDNQPSVYHIVSRTALQGLPIKDKDNDFLLGLIKKFSQFYFVDVLGFALLGNHFHLVIRMYPESDPTDDEIKERLQKYYGDELNVTGVLISDYRKRLTNLGAYVKDIKQGFTRYFNKKYNRRGFFWGDRFKSMIVQDGLSLVNLLAYVDLNPIRAGIVKKPEDYRWCSLGYHTQTGNKDGLLSIDFGMKEWNEFDPKEIVRKYRQFVYETGAVDAGKGKVMDKKIVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDERKFTPVGGVEGLYSMKRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRP0</accession>
    <name>D6SRP0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DRTGG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870714.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0684"/>
    <dbReference type="EnsemblBacteria" id="EFI33356">
        <property type="protein sequence ID" value="EFI33356"/>
        <property type="gene ID" value="Dthio_PD0684"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="687829at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="215"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="359" mass="39989" checksum="CD6C0800A9B2B559" modified="2010-08-10" version="1">MVGLYIGSTHGFSGKNLITLALGKKFKDDGIKIGYMKPVGAVPREIEGRMVDEDAYEALKFLDIKVDDPASVTPVLISQDFMQKAYTGECLLYMQDIKKAFDQLHKDNELMLIGGSGSYLYTGKYCNLDGMSISRALGSKVILIDRYKQELNYDYLIAAKEMLGDDLVGVILNDVPENFMREAKEYVTPMLEHRQVNVLGTIPHDPLLKAISVGDLAKELGGRIISMQSKSDQVIQNFLIGTMQIENFMAHFHKNKNSAVIVGGDRSDLHLVAMEGNCPCLILTGNIYPNDIVLTRSEVLGIPVIVAREDTFTVAQKMEKILNRTKLREEVKIKQGCQVVNDNLDYKTLYKNLGIQGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRP4</accession>
    <name>D6SRP4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33360">
        <property type="protein sequence ID" value="EFI33360"/>
        <property type="gene ID" value="Dthio_PD0688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="36" mass="4236" checksum="D261E05FF92BB4C9" modified="2010-08-10" version="1">MPNIITCYFPYGYDYFQHTGQAGMHNCLQFEDIADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRP8</accession>
    <name>D6SRP8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870722.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0692"/>
    <dbReference type="EnsemblBacteria" id="EFI33364">
        <property type="protein sequence ID" value="EFI33364"/>
        <property type="gene ID" value="Dthio_PD0692"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZF7E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="177" mass="19658" checksum="46F50E7AAA2AEB76" modified="2010-08-10" version="1">MKWLASAAAKRSLGYIAFTVPVLGLLIVLGVMPVREDLTSQEQEKARLQAEIKRQEVFQPLYAEIMQRREEPEPPDAVKDHHRDIADAPSIDVIADRLGAMAADSGLDNISFSPVPQSLDNDSGLLLVNGQMQGPLQNFRELLLRLAGTEAFEGLEDLEIHGTESLPRYSLSLWVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRQ9</accession>
    <name>D6SRQ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870733.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33375">
        <property type="protein sequence ID" value="EFI33375"/>
        <property type="gene ID" value="Dthio_PD0705"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2103231at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022148">
        <property type="entry name" value="CopG_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12441">
        <property type="entry name" value="CopG_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10626" checksum="8A86CFDB620F4A72" modified="2010-08-10" version="1">MKKNEYPQKTSISQADSLEAVSEFWDTHSLAEYWNETSEVHLEVRAEQRRRITLDPDIFSQVESQARSRGLLPQTLVNMWVAERLSMEKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRR5</accession>
    <name>D6SRR5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0712"/>
    <dbReference type="EnsemblBacteria" id="EFI33381">
        <property type="protein sequence ID" value="EFI33381"/>
        <property type="gene ID" value="Dthio_PD0712"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="192" mass="20971" checksum="D7528516A5495A1D" modified="2010-08-10" version="1">MPHAIQYNLLTFTPCFPIFKFMTIKNKTCSPNIPSPSRGFTMLEIVAVLVILGVLAAVAVNRFTDIGAKDVAAANTLKVHLRYAQLRAMGDVNDWGIEIEADTYTLVRDNGNVPTGNSLPDLPGAPYLPGEDSYKNENLDATLSPQDTIMFSAARGRPYLEGSDPENFPNPYEITVGNSQTINITTETGFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRX0</accession>
    <name>D6SRX0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870788.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0770"/>
    <dbReference type="EnsemblBacteria" id="EFI33436">
        <property type="protein sequence ID" value="EFI33436"/>
        <property type="gene ID" value="Dthio_PD0770"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17710" checksum="9A0E0AC871A67114" modified="2010-08-10" version="1">MTRDGISRRVVADRVQWVETMLEKIRELPIENRDEFFADSRNALACESCLRRALEALLDLGRHILAKKFRRAVEEYKEIGPALAKEQVITESQAQLFRIMAGYRNRMVHFYHDVSDEEIRTICTDHLGDIVLVLESLKRWLRDQLHGSDSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRZ0</accession>
    <name>D6SRZ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0790"/>
    <dbReference type="EnsemblBacteria" id="EFI33456">
        <property type="protein sequence ID" value="EFI33456"/>
        <property type="gene ID" value="Dthio_PD0790"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="38744at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="887"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="911"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="962"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113274" checksum="9F743AEA041428B2" modified="2010-08-10" version="1">MMNIAELAITKKSFFLFLTLVLSIAGVIAYFSMGKLEDPEFTIKTAVIITPYPGASPTEVENEVSDHVEKAVMRLDQLDYVQTESRPGVSIAHVHLKEDIPADEVPQHWDRLRHRIADIRPDLPPGAGEPEIIDDFGDVYGVLIALTGEDYSYSELLDYAEMIQKELLLADEVARVEIWGQQQETVFVDISRARLAELDLSMNQVMGFLESSSMAADAGKADLGRERVRFVLGGQFESVQDIRELELGYARHPELESMIQLGDIAEVRRGYLDPPATLIRHDGQKALAIGVSTVSGGNVVHMGQQVQDALESLQDRLPVGVQTDFVAFQADKVTEAINTFMLNLLQAVTIVILLLLVFMGIRSGLIIGSGLLLTILVTFTLMLALGMDMDRVSLGALIISLGMIVDNAIVVTEGMLVKIQTGTRRLQAAVESVRETGWPLLGATLVAVFAFMPIVLASDDTGEYTRGLFLVIAISLISSWILAMTLTPLWCHMFLRRGKAQGQEPSDPYAGRIYQLYRRLLHLCLRRKKSLLAGMALLFVLAVMGFYLVDKTFFPPSTRPQLKLDYWLPEGTRIHSTSQDLQKVEEDILKHPGVESVTSFIGEGAPRFYLAMEPHMPNPSFGQVIVNLYRASDLDEVKEYARGYLEENYPHAQPRVRKFPMGPPVEFSVEVRFSGPDAQVLRGLARQAEDIMYNDPDSREVRSDWRQMVKTYDLDYSQSRGIRFGVTREDAARAVKLNFDGLQAGLYREGDRMLPIILRPPEESRQRLEDMFALDVRPMGETRGAPLGQVVSSATLGWEEGVIIRRDRQKTITAQCEADQGGGQALMERIRSDIEAIELPPGYRMQWGGEYEQSRDSQKEVFSGVPISFLFMALAVVALFNTLRQPLIIAMVLPLAMIGVTLGLLATSQPFGFMALLGTLSLSGMLIKNVVVLLDRIDNNLASGEEPYQGLVNASVSRLRPVMMATLSTVMGMTPLLLDIFWLSMAIAIICGLTFASVLTLLVAPVLYALFFGIKTPEGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS01</accession>
    <name>D6SS01_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870819.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0801"/>
    <dbReference type="EnsemblBacteria" id="EFI33467">
        <property type="protein sequence ID" value="EFI33467"/>
        <property type="gene ID" value="Dthio_PD0801"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="9"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="370" mass="38222" checksum="3BC23DFD4D0FDCEF" modified="2010-08-10" version="1">MNRVFVQDIRIATALGNLEQTFAGLLRGSTGIGPINRGFSGNAATIALLEQPDNTSCIHTLLELVLQDFPGLSRDTVPFAATTKAGVDSLEKVMRGIPADIQTAFPQWLLSRVRRRMSLDSPGLAVSAACASSTIALARAAREVAFGRAESVLVVCADVVSQFVYQGFSSLHALDKSACRPFDSNRSGLSLGEGAAAIHVVSEDRVRENTVSVIAEISGWGAACDAVHITAPARDGCGLIAALNQALSRGGLSAGDVGAVHAHGTGTVYNDAMEITAFKSVFGDRARPVYSVKGALGHTLGAAGGVEAALSIKSLHAGVVPPTVGLEDPEDAAAGYVSSRSSSLDRRVIVTTNSGFGGINAALVLKLPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS65</accession>
    <name>D6SS65_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ORF">Dthio_PD0865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870881.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0865"/>
    <dbReference type="EnsemblBacteria" id="EFI33531">
        <property type="protein sequence ID" value="EFI33531"/>
        <property type="gene ID" value="Dthio_PD0865"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701464at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="160" mass="17010" checksum="23159C4FDCA97DEC" modified="2010-08-10" version="1">MPKVAIFMGSKSDLDLVKPCAKILSDLEIEHFMTISSAHRTPVRTKELVQEMESKGCRVFICAAGMAAHLAGAVAAQTIRPVIGIPLAASSLSGWDSLLATVQMPPGFPVATVALDKAGARNAAWMAAQILALEDDALAGKIRQAREKMARDVEEAARDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS76</accession>
    <name>D6SS76_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="2">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-IPM isomerase</fullName>
            <shortName evidence="2">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">leuD</name>
        <name evidence="4" type="ORF">Dthio_PD0876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870892.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0876"/>
    <dbReference type="EnsemblBacteria" id="EFI33542">
        <property type="protein sequence ID" value="EFI33542"/>
        <property type="gene ID" value="Dthio_PD0876"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1384217at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="3">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="17591" checksum="89B75588A8D79686" modified="2010-08-10" version="1">MHFKGKAHKVGDHIDTDAIIPARCLVTTDPQELGRNCMAGLEENWVSRINKGDILLGGKNFGCGSSREHAPIAILGAGIPVVVAHSFARIFYRNGFNMGLVLLEVGDEISRLSDGDELEIKALEGKIINHTTGDTVNSLPVPEFMADILAKGGLINYVREKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSC4</accession>
    <name>D6SSC4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870940.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0925"/>
    <dbReference type="EnsemblBacteria" id="EFI33590">
        <property type="protein sequence ID" value="EFI33590"/>
        <property type="gene ID" value="Dthio_PD0925"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1996951at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="10358" checksum="FDB6CC0FEF98CE69" modified="2010-08-10" version="1">MPEYNLNILGLDLNFKTDAGPERIEQARAYLEKRYTELQSRGGKLSKERLLIYLALGLADDYLQSDIRLSDLQQRVDELVNKIDSLEADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSD6</accession>
    <name>D6SSD6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein 2</fullName>
            <ecNumber evidence="5">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870952.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0937"/>
    <dbReference type="EnsemblBacteria" id="EFI33602">
        <property type="protein sequence ID" value="EFI33602"/>
        <property type="gene ID" value="Dthio_PD0937"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="60"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="261"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="599" mass="68142" checksum="2E122EAEA7F3024C" modified="2010-08-10" version="1">MSLFEEKSLLREKLGYNFLLFLVVALFCVFAVRLWYLQVYKADYFFEKAQDNVQRRQLVYAPRGLFQDRDGRLLAVNEPSYSLALVREDTPDIDRTLKQISRWTNIPLEQIRAEFERGRDMVRSFEKQVLVSNLSYELLTRVETEVPYWPGVKIMVQPRRKYPQGEVLSHVLGYVAQASEEELKRDPGLRLGDNVGKHGLELTMEQTLRGTKGLKQQEVDAAGRVLREQVLQYPESGQNVQLSIDLDLQKHIYSQMQGKSGAVVVLDADTGQVRALVSTPGYDNNKFVFGISHADWRDLIEDPHRPLRNRTIQNAYPPGSVFKPVMAALGLEEGFDPEEEIFCRARYRLGNRVFRCWHHHGDVDMSKALVQSCDTYFYKLARKLGVDKMSPFAKKSGLGKPTGINLPHERAGIIPDRDWKLRNVGEAWRGGDNLNMVIGQGFVQTTPLQMAVFTAALTNGGTLYRPSLLLEEKKLDPQPLPWQEETLDFIYQAMVDTVEKERGTARRLRTRDVEVGGKTGTAQVVRLMPEHEDDELEAVDYWFRHHGWMISTARKGDENYAVATLVEHGGSGSGAAGPVVKSIYDYLFSSEKAAQEDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSI4</accession>
    <name>D6SSI4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nickel-dependent hydrogenase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870999.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0986"/>
    <dbReference type="EnsemblBacteria" id="EFI33650">
        <property type="protein sequence ID" value="EFI33650"/>
        <property type="gene ID" value="Dthio_PD0986"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1967820at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="518" mass="57052" checksum="A4D90431E052167A" modified="2010-08-10" version="1">MSSKSVRTSLNIPLNRVEGDLEIQAAIEDGCITEARSSGTMYRGFENMMTGRGTLDGLVITPRICGICSLSHLTAAVEALEDISGTTPPDNARRLRNLALMVEMLQSDIRQSILMFMVDFTNEGAYASHPLSSLLMERYAPLSGTSAIQSIQETRRLLEVVAIIGGQWPHTSFMVPGGVTSSLGTPELLRCCMIIENFQSWYEKNVLGCSISRWHQVDSAQAMLDWLEEIESHRQGDLGLFLRLAYDAGLDTMGQGPDGFLCYGGLPLPEHTEVKGQQGQFIPAGFARHGSIQAFDPANIAEDISQCPYSQKHTSVHPWDSSTNPDPYAPRENSYSWIKAPRYNGHAVETGPLAEMLVRRDPLFTDLIQRQGSSVLSRQLARLTRPARLIPAMLAWLRELSSNPQGKFYHRVKKIPDGQGAGLIQAVRGGLGHWVQIVDQKIEHYQIITPSTWNGSPRDGDNNPGAWEKALEGTFIKNPENPVEAGHVVRSFDPCLVCAVHSLHRGRKKGVLVLGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSN6</accession>
    <name>D6SSN6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871051.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1041"/>
    <dbReference type="EnsemblBacteria" id="EFI33702">
        <property type="protein sequence ID" value="EFI33702"/>
        <property type="gene ID" value="Dthio_PD1041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="15288" checksum="B64A66B991225CF7" modified="2010-08-10" version="1">MVYVDTSAIVALLTLEPKTEQVISWYARLHDMPAGSDWLLTEFSSAVSIKLRTGRINEATAKLVRKEFDSLVDGGLRIVPVSRNAYRQAAAMIRRRESGLRSGDALHLAVALELGASHMATLDCTLAANAKNHGLELVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSR7</accession>
    <name>D6SSR7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871082.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1072"/>
    <dbReference type="EnsemblBacteria" id="EFI33733">
        <property type="protein sequence ID" value="EFI33733"/>
        <property type="gene ID" value="Dthio_PD1072"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="289"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="425" mass="47676" checksum="0432A17D366C56C3" modified="2010-08-10" version="1">MENFQSARILVVDDDRSTLDFIVFHLENAGYQVFKADTGQQAMDIVGRERPEIILLDVYLPDEIGLELCSRIKSEPAFNDPSVLIMSAWAPRSEMAETLARGADDYIVKPINPQELLPMIKARIKARQAQQELRQQGRALHLILDSIQEMMLYMDKGYNILWANRAAQDNIGKDFAQISGRTCHEILHSADTPCQDCPVQDTFVSGRPSSGRVSFNDGRYWYNNGYPMQDSAGGHAGVVLMSLDITQQEKSRQKCEYMAMYDSLTGLGNRNLFMDRLEHVLSQARRYGNFVGMLYLDLDGFKEINDRLGHAAGDEVLVETARRIKSCLRESDIPARLGGDEFAVILPQMKNPREAEEVAGKILEKWNPQFDTSAGKAVNMNISAGLAAFPEHGDTLDRLVNTADKAMYQAKKTKGPSFVWAGEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST37</accession>
    <name>D6ST37_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871202.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1192"/>
    <dbReference type="EnsemblBacteria" id="EFI33853">
        <property type="protein sequence ID" value="EFI33853"/>
        <property type="gene ID" value="Dthio_PD1192"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="197"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="280"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="487" mass="54259" checksum="F7D2FB29CB07BC73" modified="2010-08-10" version="1">MFKKIASFSRLFSLRLALVVYVVLPLACILAVTGYLVLNALERQVEQQMQNDLELVARSIQLPLSHALERDREGSMIQALESAFAIGRVYSANVYDKDGQEIASAGRTDPDPEKDKLTELAAEGERRGEYGHVAGREVYSYFVPLTDSGGRISGLLQLTRRESDFKEDISAIRTKGVMGLGVAVFFMSALVLYGHHKALGKYFTRLTQSMSRVAGGERRHRFKPQGPREIVTIGERFNFMLDSIEKAETEIRERRQAQEELQARLRQAEKLAALGQLAAGVAHELGTPLSVVSGKAQRAQRKKGLPPELNATMQEIRQEVERMENIIRQLLDFSRRNEQQKRNVSMKQLARSAHASAEEEARNTGHELSIQEPDREIHIKADPTRIEQALVNLLKNALQSSSNALARISWGEDSGWAWFQVDDNGPGISEDIKSKLFEPFFTTKSVGMGTGLGLAVVHGIAEEHSGYVEVGQSDMGGAMFRIWLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST42</accession>
    <name>D6ST42_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AsmA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871207.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1197"/>
    <dbReference type="EnsemblBacteria" id="EFI33858">
        <property type="protein sequence ID" value="EFI33858"/>
        <property type="gene ID" value="Dthio_PD1197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1068066at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007844">
        <property type="entry name" value="AsmA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05170">
        <property type="entry name" value="AsmA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA" evidence="3">
        <location>
            <begin position="273"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="645" mass="71458" checksum="05CC047B99136A88" modified="2010-08-10" version="1">MARTIKLTLAIVGILLFLIILAIIILPHIVDFNKHKPEVEAGIYNATGYEVSLEGDIELSFLPWLGIDVGKASVANPPDFEDENLGSVEALQIRLKVWPLLLGQVQMDRVVLKGLNLDLVKDAQGRPNWIASRPEESREGVMLGSSLAYAGENEPAQQDSGDIFIPALDIAGLEITDSNISYKDMGTDVHFRIEDLDLLTERIRQDEPFDLQSDMKFKNFSPELDGRISLTTQALLQGEEKSIRLSELDMDLDLSGEPLHEPVKDARIRGDIVYAFGANSMEFSELSIQALDADLSGKISARELDAVPQIRIDLEGDNLDLDRIMPPPEENSETGNNPGNSPNSNPENDDKNNMDLGFLHDLALEGEIKLTSLKAYQAVIDELSAQITSGNGEMVISPLTAKLYQGTFEGLLSLKDVQDEAHIEMDSSLRDVQVKPLLQDVAEKDFLSGTAELDSELKTFGKNTDLFLENLFGEARIEVRDGTIRGMDLDHMIRDGFAAAFGEERPSRDDEETTRFSSFKGSFDIASGIASSQDLELDSPALGMTGDMRLDLPESYLESRARVTLAGALKEEIEERYALPQAGIPLRIRGPFDDVSVGLDIEDIVRDLLREKGEGLLQQLMDQMDPENEEQENGARDMLQRFLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST82</accession>
    <name>D6ST82_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871247.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1237"/>
    <dbReference type="EnsemblBacteria" id="EFI33898">
        <property type="protein sequence ID" value="EFI33898"/>
        <property type="gene ID" value="Dthio_PD1237"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14743" checksum="18D3B51C5BF90B58" modified="2010-08-10" version="1">MSVSWLHIAIIYFFVLGIVFFAVVPFLLSHLLAPKARAEKLRMPYECGMIPHGSAWVKFGINYYFYALIFLAFDVDVLFLFPVATHYVEAPDLVSFIKLLIFIVILFASVIYFWKKGVFTWPKKIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST83</accession>
    <name>D6ST83_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871248.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1238"/>
    <dbReference type="EnsemblBacteria" id="EFI33899">
        <property type="protein sequence ID" value="EFI33899"/>
        <property type="gene ID" value="Dthio_PD1238"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="754526at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1458" mass="160009" checksum="03B286AF5E6CB1D3" modified="2010-08-10" version="1">MKRYIKRGIIALGILLVLLVLLVGAALAWLQTDSGQKHLESTLNRVLVWEDGRVEISGISGRIPFNFEVQSIEIHDKDGVWLELQDSGLDWSLGDLFQGRIVVRKLGAAALYMSRAPHTEPMEEPEVPDELKKKLEWKWPLPPLIVESLYLDRARMGEEVLGEEAEFFMQGALSAYQTGFAVDGLNISRLDKDETSLDMSMDFSHNSHELELYLRFFDSATLPALVPAEDMPDSLELVLEGTGPVQDWPGSLTVRGGDLLDLAMDMNMKLLEESLEFSADAEASISPAIAPEPLDFYLGHPLHLKTQLSMDYAENLLSLQSLHLDSEQFSLDSRAELVLDEMFMQGSAEMLVQDLNPLLDKAQFASTSPAELEAEFHGPVTSPGGQVNLWLEELKGHDLDLASLHLQADLEYPGEVNGTTALARGRVMLQGLGYEHYPQLPGEMEIGFDVDYADSGLVDFKELRLVSRNLEALARGRIDLDDLNFEAALESKISALENLMPEEAADLELAGSLNFKADTHGNIAEETYNLQLSLSGEEFSSGQDLLDALVGDKPGLRAAASMSEPYILELEELELITKEAEFFSSGLVDLKKMDMDIEAGLDMASLEFLGATLDRETGGSLSARATARGGPEELELNLDAGLDGVKPGADLDLMDIQASVDSVYTRESFSGKVQASLDSEQGSVELGSDFELVEKNLKVANLFLSGFDSSVRGDLDLDLDTFLAQGALDVDVPELSAFAGLAGLEIYGDLQGSVFLDKTRDRQDATLDFQAMDLLVDSMSVVYLELAGQGQDLFADRNYNIELNLAGLDLGEAYLSSWETEVQGQDTDLGLVTSLEGRAVYPLELKADASYSLDRGDHLIDLDVLQGIYAFEDFSLLKPFQVKVGDEEINISPGELAWGDGRLEFHGGLNSEEVFFEAELHDILLSQLPLEAFEVVEGRLTGDFKVHGDPAGPVVTAGVGLSELRSRHPDMEDMPRLDVNADLLVEDGAVQLKAALFQGPDELLGLELGLPAVFSLEPAVFELQDPAVLQGRLVSDVELAKVAPLFLPPELTLSGILQSGVDISGTLHEPELDGKIELDDGVFEHTVAGVYLKDINALIRGRNDQVVLEELAASDGEAGRIRGSGSLGLDPEMEMPWDFDLQIENTNILRHPLAVVNITSCDLELSGDMTRASVKGSLTFGSIDARLPPGSPPGVVHIDVTEKNKPPSDLPPPPRQMDLEDYPVDLDLELNFPARVYVRGRGLDSEWAGHLYIDGKAHEPRIRGELSPVRGRFTFLDRRFDLDRDSQVYLDGAYPPDPTLDMRAHYRQRDRNITVRIHGRALNPDLDLESDPPMHEDEILAWILFGRDLSDLTPFQALTLLNAVRTLATGEAGPGVMDQVRSLVGVDDIQVTRDDEGELQFGLGRYVHERVYMQVKKGTAPGSDEVAVEVELTPRISLEGSVEADADGGVFLFWKRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST92</accession>
    <name>D6ST92_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871257.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1247"/>
    <dbReference type="EnsemblBacteria" id="EFI33908">
        <property type="protein sequence ID" value="EFI33908"/>
        <property type="gene ID" value="Dthio_PD1247"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="120"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="27635" checksum="65DD191E6C18DCF3" modified="2010-08-10" version="1">MARRKSKKGGAPKPIWMFTFSDLVTVMLTFFVLVLSMASLDREYVQEIVTVFQQDTGFLTPKTAGRLPDEFVIIEDVLENPWEILEKEDRIKDLLFPEEELPPEISKSTLEENLEILMRPEGIALMMTGELLFPFAETRLQPQARQILDQVIPLVKAWPAPVNVAGYTDNIPGIHMDNYEFAAERAMAVMEYLLINDVKQQRLSVSAYGEHFPVGDNETEEGRARNRRVEILLKKTPDTYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STC6</accession>
    <name>D6STC6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871291.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1281"/>
    <dbReference type="EnsemblBacteria" id="EFI33942">
        <property type="protein sequence ID" value="EFI33942"/>
        <property type="gene ID" value="Dthio_PD1281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="118" mass="13485" checksum="4F53FDDD99F39DF4" modified="2010-08-10" version="1">MNQSTLEAPQAIPVRSPGHEVNGHEKVGVEWVCTLFVNRLVNHVLKQPLSIIIEPDKHMILARCPDLPLYGCGEDTIEAVDMLKREIESLWEDLKEEQDLDAEWSSIKRTLDDNISWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6STE9</accession>
    <name>D6STE9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871314.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33965">
        <property type="protein sequence ID" value="EFI33965"/>
        <property type="gene ID" value="Dthio_PD1304"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2075734at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="159" mass="18676" checksum="BA5540000E610635" modified="2010-08-10" version="1">MDAWDLLIYLMIFLAAVVGTALAYARMLDWKKRNIKLLEQRLAETQKHYNELTKEVGDLKLKKNRLRSELQDRKKVQDMNSETRQKEQEHDQEWAEDQLPESLSYLLNKGIVEHKHIEKARQYLEKGDNAGLAVEDAMVLLGFVQPEDLRKAKKKVQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6STF2</accession>
    <name>D6STF2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ORF">Dthio_PD1307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871317.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1307"/>
    <dbReference type="EnsemblBacteria" id="EFI33968">
        <property type="protein sequence ID" value="EFI33968"/>
        <property type="gene ID" value="Dthio_PD1307"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="132"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="361" mass="39123" checksum="69110D4C66929EA2" modified="2010-08-10" version="1">MLSLGIETSCDETALALVDEGRILQEVMFSQVDKHSIFGGVVPEMASREHLRKLQPLWHSLLKKSERRAGDVELIAVARGPGLLGCLLVGLGFAKGLAMGLKIPLVGVNHLHAHLMAPALEQEIEFPAVGLLVSGGHTSLYKIDSSIEFELLGRTLDDAAGEAFDKTARALNLPYPGGVYIDRFASFAEPDPDMFPRPYLDNPSLDFSFSGLKTALVNHIRKHPGLVQENPLEITPDSTPDPELARVCASFNLAVAETLQAKLQRAVSATGVQNVILAGGVAANSMIRQKTIKLCSSMGLRLILPSLNLCTDNASMIACCGEILARHGLYHDLELEAVPRGRKIPWDYCGLKNSGIEEFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6STI3</accession>
    <name>D6STI3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein Dthio_PD1338</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871348.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1338"/>
    <dbReference type="EnsemblBacteria" id="EFI33999">
        <property type="protein sequence ID" value="EFI33999"/>
        <property type="gene ID" value="Dthio_PD1338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="132" mass="15200" checksum="CF1F09923F857457" modified="2010-08-10" version="1">MSAHNLNLGRYGEEVARDYLTENGYRIKERNWRARGGELDLVCTCGDCIVFVEVKTRAEEGMGHPLESLGFKQQKKLLRTAGLYLSRHNMWSSQSRFDFICVTVGREVQIEHIQNAIEFSSVGRGHTPWQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6STM0</accession>
    <name>D6STM0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871385.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1375"/>
    <dbReference type="EnsemblBacteria" id="EFI34036">
        <property type="protein sequence ID" value="EFI34036"/>
        <property type="gene ID" value="Dthio_PD1375"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="144"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="273"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="734"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="812"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1186" mass="134311" checksum="E3B225190E32CB2E" modified="2010-08-10" version="1">MPENNSPVNNPSQAQGSPLTDDIFMSAPIGILTVDPGGMLLSANPALAQILGYSDPQDILDKTGGTAWQSFADARDWQGLYRMLEADNEVANFECRLLCRDNNPLWVSITAGAIRDDTGRLMYIRGFVTDISERKLAENALRRSEERYRMLSESTNDFIFSCVEGQTGHNLEWLAGAVEKITGYSVEDILANQCWSFLVHPEDRYLFREHITECEPGQTKECELRILRRDGQTCWLQVASSCFLEDERGSKKVYGACRDITGKKTAEKALQESEFRYRNLFEKSTEGVFLHDLEGNILDANESALEMFGYTREELIRLHPSSLVHPEEVQQVREEFEDIKRNQSRFSEHRCLRSDGREIMVITRGRLVSENMIQGVLRDVTRERQQEKALRESEEYIRTIMEVLPDIVIKTNLQGVCLDVLGDFQAKLYRPKEEVLGRYIPDVVPEEVGTRFMQGVNNALTTGDLQMVEYELEIDSRTFYFESRIMPLNEEEVIALIRDITENRRALAALEESESRYRQLFQESPASMLVEDFSQVQKRLGEIKNQADGELDSFLKENPQFVQEMAELVRIVDVNQTALKQFHAASLEEFTRGIATVFARDSWQEFMGELAAVFHGEKSFFTEKRLQNLNGEIRNVQLKWSVMPGCEQDFSRVLVCIVDITGLKSIEEDLRHKNMLLNGVLDNMPDFMSVKLPDLTVVRYNRTGYELLGMDENEVQGKKCYELMNQEFPCQPCATLDALKRGGQADHELYFPQFERYFSCRANPILNEEGRVEYVVELLRDITQRKESEAELQMAWEKAEAANKAKSEFLANMSHEIRTPINGIMGGLQLLEATSLDHEQKQLVEMGIASARRLTRLLTDILDLSRIEAGKMEIRKADFEVDRLCTSIEDLFAASAAEKNVRISCTLDPRLPPILAGDDARIQQILLNLVGNALKFTHDDTVELHWHLLRRQGNELRVLISVADSGLGISDEKLGEIFNPFVQADGAFTRNFEGAGLGLSIVVRLVQMMGGNISVESTPGEGSTFYVSLPLEAGSGESAGENKENIQVKAGSPGLRVLLAEDDPSNRFFMQKVLEREGHIPLIAQNGQEALEQFQKHAFDCILMDINMPVMDGMEATKEIRRLEAGGSRQEEDGTYPAIPIIALTAHAMGGDRERFLEMGMNDYLSKPVQVQELRTALDKITPDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6STM1</accession>
    <name>D6STM1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD_binding_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1376"/>
    <dbReference type="EnsemblBacteria" id="EFI34037">
        <property type="protein sequence ID" value="EFI34037"/>
        <property type="gene ID" value="Dthio_PD1376"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="2">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="649" mass="72980" checksum="4BABEE0AAC7094F2" modified="2010-08-10" version="1">MPKRVQAKFFQGEAMEYNIVIIGGGPRGTYCLRRLSLALAADPPENPVNIHVVEKSGRFGGGNVHNVDQPHYLLLNTVSCQITAFGDDDAPARAEESRRTLCGYLQEKGYDYGENDYPPRALHGEYLAECFNWMEDNLPQKVSLYRHAAEAVDIKTAEQGLQEVVLDNNEKICACEVILLTGHSRNRIVPGSREERYHQFAQKQQQKGGNISYVHLAYPIASQMEHIQADQSVYVIGMGLTATDVIRGLTHGRGGRFSSGRYIPSGNEPHIILGSRLGLPYCARGKNQKTGQYQARIFTSNLVHRLIQEKGKLDFRKDLFPLILQEMEYVYYSTLMGDEFGRKYLQYLDSAQRQDLVKREVKSTDRFNWQDLANPLWKLEAARKSGKPLFESMEHYTDFVLKQIGFDLSEAKKGNVGSPVKNAVDSVLRDLRDTLRSAVDHGRLTADSHRYMKKTFERTNNRVAVGPPIESVQELWILVRQGLVSFSGPSPEVHANEEKGVFQVSSPEVPGSIREVSHVVNGRIHGVDTRNDTSTLMQNLLKRKMVRTFTSSDHTGSFEMGGLDVTHDFQLVAADGSVHENICALGIPVEGKLWFNAADARPDVNSNAITQLAYWSRSAVERIHRREQSAKPGLSRTEGTEEQFVREET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STN1</accession>
    <name>D6STN1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding lysin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871396.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1386"/>
    <dbReference type="EnsemblBacteria" id="EFI34047">
        <property type="protein sequence ID" value="EFI34047"/>
        <property type="gene ID" value="Dthio_PD1386"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2046643at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="206" mass="23713" checksum="079B1D4BCB6D3C45" modified="2010-08-10" version="1">MEKKNWINKLDDLEEDQPKENSNPRRKQFGMGRPPDNLISYIAGGAGIALVIILVVIFARGGDDVSSQELQEISSKLQNLEERMQILEEQAEERQVAFTDIWETSRDLNRRLEDQRENIDDMRQQLAALEEDPPVRPDPEPVQPPEPAERPEPEADEEYVYHEVQAGENLFRISLEYDISVDEIRELNDLGPDDPIQPGQKIRVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STN4</accession>
    <name>D6STN4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871399.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1389"/>
    <dbReference type="EnsemblBacteria" id="EFI34050">
        <property type="protein sequence ID" value="EFI34050"/>
        <property type="gene ID" value="Dthio_PD1389"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="27583" checksum="E74E205565CD24E0" modified="2010-08-10" version="1">MSRQVQKYFDRAADTYLEEAVIQEEAAGQCAGNIPRGYYPRVLEIGAGGGLLTRHCLERIRAGIYLAMDVSFSMLGLLPRDSVVPVQGDGETPPLREGSLDLLVSSSVMQWYAGGGQSIARSLRLLCPGGFFSLSFFVAGTFRQMKHISSMSGFGSVYPLPRVRECMAAMARSGTEYTSRVENYTVYYDSVQGFLKSHKGTGAGYTGRRPVFGRQCYRNFCRMYLETYGEGGRIPVDYRVLYIRGQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6STP5</accession>
    <name>D6STP5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871410.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1400"/>
    <dbReference type="EnsemblBacteria" id="EFI34061">
        <property type="protein sequence ID" value="EFI34061"/>
        <property type="gene ID" value="Dthio_PD1400"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003814">
        <property type="entry name" value="FmdEsu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02663">
        <property type="entry name" value="FmdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="373"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="538" mass="59213" checksum="917DA8F769889B4D" modified="2010-08-10" version="1">MRIGGYEFEEFLEVVRNFHGSPAPGIIVGGIMVDMARDALPPDTIFDAVVETPKCLPDAVQLLTLCTVGNSWLKIVNLGRYALTFYDKYTGQGVRVFVDPVKLEKWDEIKGWILKLKPKQEQDFERLMHQIRTAGRDILTARPMQVDMDQLTRKKMSSIAVCPICNEPYPADDGAACRGCHGDSPYISEGEDMQEPELEQVSVHEAVGQKAAHDMTGIEPGKSKGVVIKRGQEINFSDICRLQQIGRQNLYTEAAPSDKDWVHEDEAAESFARAMAGEGVELGLPPREGRVNLKAGRDGLLVAQKDNLLAFNLVPQVMCASRQSYMLVKKGSVIAGTRAIPLYLPRSNFNKAMQVLNQGPLFKVLPLMQKKVGLLITGTEVFEGIIQDRFEPIIKDKVQKLGSEVNRSIICPDDKEEIKSCLTRLLDSGCDMIITTAGLSVDPDDVTRKAIQEAGASEMLYGAPILPGAMTMLCWIDSVPVIGVPACALYFKTTSFDLLLPRLLAGLKITRLDLAQMADGSLCLACKSCTYPKCPFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6STQ8</accession>
    <name>D6STQ8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="5" type="ORF">Dthio_PD1413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871423.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1413"/>
    <dbReference type="EnsemblBacteria" id="EFI34074">
        <property type="protein sequence ID" value="EFI34074"/>
        <property type="gene ID" value="Dthio_PD1413"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="150"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="121"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="315" mass="34636" checksum="3E908BACBC40A0EA" modified="2010-08-10" version="1">MLKSEDHFLEIVNSLFPREHPHMVVGRGDDCAVLKCPASLCMSSDLFLEDVHFRTRYFTPEDIGHKALAVNLSDLAAGGARPLGFNLNLIWPVYLDEEFCRSMLSSMAELGAKFKLALTGGDLSFGKSLGLAVCIWGKSPARQMLRGKAEPGDVLFVVGKAGLAACGLSLLEENDPGLDRYPECVAQHLRPRPLVREGQVLAGIEEVKGLMDVSDGLARDLPRFCRRGTGVEICSDFRVHPEVAFFCRDRGLDPLATALKGGEDYALLGACTRKGWDTVKKKILDCRRLGTVTDKPGIFLQDRELGLKGFDHFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6STR4</accession>
    <name>D6STR4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1420"/>
    <dbReference type="EnsemblBacteria" id="EFI34080">
        <property type="protein sequence ID" value="EFI34080"/>
        <property type="gene ID" value="Dthio_PD1420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8473" checksum="4D4A19C04415E779" modified="2010-08-10" version="1">MLNPKFINELKESGVPLHRLAWESGLTPSQVYRITCGIERPEPGCRKVEALCRHLKMDPEEAFVTNRQEGHRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6STT8</accession>
    <name>D6STT8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1444"/>
    <dbReference type="EnsemblBacteria" id="EFI34104">
        <property type="protein sequence ID" value="EFI34104"/>
        <property type="gene ID" value="Dthio_PD1444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7595" checksum="5D6FFA9701EF5DDE" modified="2010-08-10" version="1">MGYTPELSKNHSRILRRIAWAAGAPMTTTLEAIFDWLPSKMDEEKVCSSCRDKEFCNQCPFNKPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STY0</accession>
    <name>D6STY0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871495.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1488"/>
    <dbReference type="EnsemblBacteria" id="EFI34146">
        <property type="protein sequence ID" value="EFI34146"/>
        <property type="gene ID" value="Dthio_PD1488"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2089718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="208" mass="24502" checksum="AAE6382F6CE719B7" modified="2010-08-10" version="1">MDAKEAMLSAMKEWMLPELNSIREDYKNIKTTLDMTNKRLDEMKAHLVDQGRRIDDTRAELKAEIQKNTERIDETRAELTTRIDETRAELKTEIQKNTERIDETNRRIDETRAELKTEIQKNTERIDETNRRIDETRAELTTRIDETRAELKTEIQKNTERIDHINTRIDNLTREVAEVRGDLNKALSDKVVVQDLVERVGRLETRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU16</accession>
    <name>D6SU16_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KilA-N, DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871799.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0422"/>
    <dbReference type="EnsemblBacteria" id="EFI33107">
        <property type="protein sequence ID" value="EFI33107"/>
        <property type="gene ID" value="Dthio_PD0422"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1578471at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018873">
        <property type="entry name" value="KilA-N_DNA-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10543">
        <property type="entry name" value="ORF6N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORF6N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="20980" checksum="62D6D00650737CC8" modified="2010-08-10" version="1">MTDITVPMETITGKIFMLRGMKVMLDRDLAELYGVETRILKQAVRRNSERFPDDFMFELSQEEFKNWRSQFVISNSDKMGLRYPPMAFTEQGVAMLSSVLNSKRSIQVNIQIMRAFTQLRQMLASHEDLRQKIEEMESKYDEQFQVVFQAIQELLDKDQQPGKKIGFLKEDQTEYETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU88</accession>
    <name>D6SU88_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871562.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0177"/>
    <dbReference type="EnsemblBacteria" id="EFI32868">
        <property type="protein sequence ID" value="EFI32868"/>
        <property type="gene ID" value="Dthio_PD0177"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50332CF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1954291at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8311" checksum="A29FFE0AD3AD9AC2" modified="2010-08-10" version="1">MFFTKGCPLCGGKQNPGTTTFTVDKGSVLVVVRNVPAMVCDQCGEAWIMDSVAEDLERIVSEAKSKRSQIEVIDMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUB7</accession>
    <name>D6SUB7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="10" type="ORF">Dthio_PD0211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871590.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0211"/>
    <dbReference type="EnsemblBacteria" id="EFI32897">
        <property type="protein sequence ID" value="EFI32897"/>
        <property type="gene ID" value="Dthio_PD0211"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI32897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="371" mass="40997" checksum="52FD3268F1D72DE8" modified="2010-08-10" version="1">MGFQIIRPDTSFDFMGKRKIALTISLVLLFLGLASLLVKGGPRYGIDFAGGVILQIQFESEVEMGKLESLLQEAQLPGMSLQTFGDRGDNEYLVRSSAEGLTTSDVREQTRQALQAEFQEDEFTFQRLEMVGPRVGEELRENALQALFFAVLLISIYISGRFEHKWFIAGFMAAGLGLGVYLLKILGAPLVFLILAALLISIMFTWYLKLSFALGAVLALIHDVLITVGIFSLLNKEFDLSIVAALLTIIGYSLNDTIVIYDRIRENMRKKISESLTQTINTSLNQTLSRTIVTSGTTLMVILSLLILGGGIIHDFAFALLVGVLVGTFSSVFVASSILLKLRPEIPGEDEKEEVIDVKARMDMRAQKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUD7</accession>
    <name>D6SUD7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871610.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32917">
        <property type="protein sequence ID" value="EFI32917"/>
        <property type="gene ID" value="Dthio_PD0231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1899767at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="11"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="234"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="399" mass="43319" checksum="3C80616DA1D03E90" modified="2010-08-10" version="1">MSKLKGSFLPEGFFIRDWSVWTGGVLLALLALGVFVWHDMWGITAGFRNWGDWFFYGVGLYPERPEKVWLHPGSITNAGLLAGAVAAAFLSGRIRLRRSSWYGYVKSLTGGTLMGIGAALAAGCNVGGFYNATAMFSLGGYAMLPGLILGGYLGVRFLRWELYNIATRLRAQCPCKTEGKSDNAPEQVSSLGVLAGWCFVFFLAGLFLYYLFQGHAREAGLLLLGALIGITLQRSRLCFAQAFREPFINGDYAMVKVIAFSLVIYGLGAGLLKLALIQPESAGVQHPFWLGSFSGGVIFGFGMLQAGTCATGTLWRAGEGHVRVMLSMLAFAVFSSLGFFLVQKFEPAGFLGEAFFLPELMGWPLSFLFFLAVPLLWLALAAWNAKTGRMAVFGSPRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUD9</accession>
    <name>D6SUD9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871612.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0233"/>
    <dbReference type="EnsemblBacteria" id="EFI32919">
        <property type="protein sequence ID" value="EFI32919"/>
        <property type="gene ID" value="Dthio_PD0233"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2026243at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021973">
        <property type="entry name" value="SprA-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12118">
        <property type="entry name" value="SprA-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="324" mass="35070" checksum="E638AF98E5DBAF51" modified="2010-08-10" version="1">MQVSTENSPTFDHAGISGFQSAEQGQSHTCCESPCSTCGSETASQTDMQAGKSSFGADMTAGHILQGDRAVFSHAPENQQTRKSASGINISAGPEQGAGYGPDARPLPETDHRDRHSRGNQEHGLEDKPQKDSPGTQEEVQSSPRGDIDHHSEDYKQGEEEYSLRGETELSAEERQELQELRQRDAEVRAHEQAHIAAGGQYVTGGASYSYETGPDGRQYAVEGEVSIDSSPVPGDAEKTEEKARTVRRAALAPANPSPQDQRVAADAARMEAEARTEQRQEEREEQQDASESRQPEADNSSAPPPPPTMKAAIQAYQSMMNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUE5</accession>
    <name>D6SUE5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0239"/>
    <dbReference type="EnsemblBacteria" id="EFI32925">
        <property type="protein sequence ID" value="EFI32925"/>
        <property type="gene ID" value="Dthio_PD0239"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="158"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="7">
        <location>
            <begin position="316"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="6">
        <location>
            <begin position="457"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="721" mass="82424" checksum="6BE435ED060730B9" modified="2010-08-10" version="1">MSNDDTQMQENTPKILVVDDELINRSMLRKFLASRAEILEAEDGYQALELASSETDLVLLDLMMEGIDGIEVCRRLKERPDTKEVPVIFISAVNDPKVKAQGLEAGGMDFVDKPFDRNELLSRINIHLTLRNQAIEIKKYTQELEELVEKRTRQLQESEKKYRTLFETSKSAMLLVDTESGLLTMANKEFCDLIGYTRQEVENSLHFLNFVHPDDHERARKYFDTSRQDAGTAPAEFEIKGLTREEKKLHLYYKVAAIPEWNSLVISIFDLTDKRRVEEELRQRTFYNSLTGLPNSELFKNRLKKSIQTRQEDQGYFFAVIFIDLDRFKLVNDSLGHQKGDELISLMAKRLERGVKKRDTVAHFGGDDFGLLIEAEDLPEAALRAEKIKDQFVEPFEIAGNEIYTTCSMGIVVSSQDYSEPEEIFRDADTALHRAKSTGPGNYVVFDPQMHAQVSDLLQLETELRKAIQQKEFVLYYQPIYNLADLRITGFEALIRWIHPEKGMVPPNVFIPIAEETELINPLGEWILDTACRQARKWNKGGRELTMNINLSGVQFKDKNLINVLENTFRKNSISPLHINLELTESVVMGDAEESINTLNKIKKLGARLSIDDFGTGYSSLNYLQKFPIDNLKIDRSFINTMETQSGQELVRAILAMTQSLGIKAVAEGIETWEQVKLLQELNCNLGQGYHFSKPLDEESADALLQEHNTDSPAMQEKEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUN0</accession>
    <name>D6SUN0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplB</name>
        <name evidence="8" type="ORF">Dthio_PD0324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871703.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0324"/>
    <dbReference type="EnsemblBacteria" id="EFI33010">
        <property type="protein sequence ID" value="EFI33010"/>
        <property type="gene ID" value="Dthio_PD0324"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="7">
        <location>
            <begin position="124"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="275" mass="30263" checksum="030CDA29A01E5635" modified="2010-08-10" version="1">MAIKKLKPTSPGRRFQTVSSFEGINRVEPEKSLLEGLTKKSGRNNYGRITSRRRGGGTKRKYRIIDFKRNKFNVPARVVSIEYDPNRSARIALLSYRDGEKRYILAPAGLKTGAWVQAGEGVDIQPGNAMPMSQIPVGTIIHNIELTPGRGGQMARSAGTYAQLVAKEHKYALIKLPSGEVRKVLAANTASIGQVGNVEHENISIGKAGRNRWRGKRPSVRGVAMNPVDHPLGGGEGRSSGGRHPVSPWGWPTKGYKTRRKNKPSDKLIVNKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUU3</accession>
    <name>D6SUU3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871766.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0387"/>
    <dbReference type="EnsemblBacteria" id="EFI33073">
        <property type="protein sequence ID" value="EFI33073"/>
        <property type="gene ID" value="Dthio_PD0387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="131" mass="14790" checksum="FFC38194DE52E008" modified="2010-08-10" version="1">MSIKPDLGMRMVNDGISRNTVQHFYDFRLDHLSVLGRGRYTTIADTPYKGEMHAMSLDFNQEHLEQILDRAPAEIAKQVKAELSKDPLTARTIEFKGGVTISVRAGLGEIQQSLYENFVPLVVQEVLQPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUW9</accession>
    <name>D6SUW9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0008"/>
    <dbReference type="EnsemblBacteria" id="EFI32725">
        <property type="protein sequence ID" value="EFI32725"/>
        <property type="gene ID" value="Dthio_PD0008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="260" mass="28442" checksum="F90C12FCEF7B8B6F" modified="2010-08-10" version="1">MKGLTDDRIKGLTDEGMDGSVDGGMTGLRDDSMDGVLDDGMDGLKDEPGEKGIQGSNLSESQLLKLKDELQQELQATLPSQAELVVQEKNKTLADALEDTLLKLTAEINGSMVQVYKAITQIQQVMKNLEERLGQLENDLGADPAEGVELSDLDLEKMQVSHPSINIADAESIPEEAQEPAPLDDYAYADLEFVRNSIHNGKPDKAAVTQWIRSEKEKDPGITYVELAKRLKDAKIPTLSGRDEWTRALVRNLAVKGKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUX6</accession>
    <name>D6SUX6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871831.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0015"/>
    <dbReference type="EnsemblBacteria" id="EFI32732">
        <property type="protein sequence ID" value="EFI32732"/>
        <property type="gene ID" value="Dthio_PD0015"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15344" checksum="D7A13B71668FE1C4" modified="2010-08-10" version="1">MDVVVDTNVVVSGLLFKGLPGRIVSLWKQRDIIPYVTREIVDEYIRVLTYPKFQLSGLEIEYLVYQEILPYVEIVKPLTRVHVVHDDPADDMFLHCALAGQVKTIISGDKHLLDVQAYKSISILDPADFLQKFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV13</accession>
    <name>D6SV13_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871861.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32769">
        <property type="protein sequence ID" value="EFI32769"/>
        <property type="gene ID" value="Dthio_PD0061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="13140" checksum="E9785E716DF966F6" modified="2010-08-10" version="1">MQHTKLEKLCRAVVNIWDMQNSYHDKDKFIIDLAFPMQKLIMHLKKEGKRDQDAFIYAYSKNDKTAMIGEGLNIDMVNMFLIMLDQDPQIKKDVIEYIMVNDLQEIIGLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV17</accession>
    <name>D6SV17_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0066"/>
    <dbReference type="EnsemblBacteria" id="EFI32773">
        <property type="protein sequence ID" value="EFI32773"/>
        <property type="gene ID" value="Dthio_PD0066"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1785284at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="140"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="337" mass="38596" checksum="6DBDFA75CF131915" modified="2010-08-10" version="1">MGKISKSEARKIASHIITHTSNNTQQTNEHLFKIFHRIYKYGSLQTYAQTFNLKKTTWYKYKAAYQFGAALMIRKLLRDADKLEKTDKTKAKLYREEALRLGEELKSLSPDYEKKHRLNHPAPSNQAKPYTKSKIEGKRKALRGLPTNWVGRLIDELPIQHQKAALVMALTGCRPAELEKGVWLEAVDHDHLKITIKGAKYIKNKQGQKQRVLKFALEDAHRLFNLAYEEPRLVWINKEAFRKAIRRAAGNLGFKGVSPYSLRHQFSANLKRESGEKWTHEDMAKALGHITDRCQQFYGHPNQARGRGSGILNVQASSQIKSNRGTIPEKTSGPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJR7</accession>
    <name>D6SJR7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869245.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3573"/>
    <dbReference type="EnsemblBacteria" id="EFI36120">
        <property type="protein sequence ID" value="EFI36120"/>
        <property type="gene ID" value="Dthio_PD3573"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="118" mass="13471" checksum="E4145EE7EE1F57E4" modified="2010-08-10" version="1">METPFGSYVREKRLELKKTDKKYSLRQVAGRISVEPSYLSRIERGWPVPLSEAKIISLAGELGENPDLLLALAGKVSSEVQEVIRSRPELFAELIRNLKNMPDHAVLRLVREVRDGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJT1</accession>
    <name>D6SJT1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869259.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3587"/>
    <dbReference type="EnsemblBacteria" id="EFI36134">
        <property type="protein sequence ID" value="EFI36134"/>
        <property type="gene ID" value="Dthio_PD3587"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1808979at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024755">
        <property type="entry name" value="cpYpsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12694">
        <property type="entry name" value="cpYpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="169" mass="18813" checksum="37E7B7DFFDF0259F" modified="2010-08-10" version="1">MLQRKIFEKIVSGGQTGADQGALDAALELEYSCGGWCPKARKSEAGPIPAKYPLREHSSSEYKSRTEANVMDSDGTLIFFYGEPEGGTALTVKLAQKHGRPYYLFDLDNHALNQDPEIIWKWGLDHNVYTLNVAGPRESKNPGTQVLVKTAMMLLLEHAKKCYPVVEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJU5</accession>
    <name>D6SJU5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3602"/>
    <dbReference type="EnsemblBacteria" id="EFI36148">
        <property type="protein sequence ID" value="EFI36148"/>
        <property type="gene ID" value="Dthio_PD3602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="53" mass="6299" checksum="638519CB0E8D259F" modified="2010-08-10" version="1">MFIFKIHVEITYSSMIQHEALLNLFFAKGIITKEEYLEEVKRVSLELQGRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK57</accession>
    <name>D6SK57_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869379.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3723"/>
    <dbReference type="EnsemblBacteria" id="EFI36260">
        <property type="protein sequence ID" value="EFI36260"/>
        <property type="gene ID" value="Dthio_PD3723"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="197"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="412" mass="45252" checksum="4D196461BE1D0AD8" modified="2010-08-10" version="1">MRYHSRVVDCELRQRLSSTGAVVIEGPKACGKTATGRNLAASEVLLDVDENARQAVAIDPRLVLAGDTPRLIDEWQIEPAIWNHIRRAVDERGQPGQFILTGSAVPVDDITRHTGAGRLTRLRLRPMTLFELGQSTGALSLADLLNGNRSACRDSGLTIQDLVELLAVGGWPGHLRLTSRQALRANRDYLEEIRRVDISHVDGVRRDPDKVGRLLRSLARNIGTYASATGMAEDIGGITVQTVLEYLASLERLMIMEDQPAWTPHLRSRSRLRSMPRRQFVDPSLAVAALRTSPEGLLKDMNLLGFLFESLVVRDLRVYAQAMDAQVLQYRDNTGLEVDAVIHCADGRWGAFEIKLGPGMAEQGATSLLKFAERVDTEKCGSPSLLAVITGTGYGYFRDDGVAVIPITALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK62</accession>
    <name>D6SK62_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869384.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3728"/>
    <dbReference type="EnsemblBacteria" id="EFI36265">
        <property type="protein sequence ID" value="EFI36265"/>
        <property type="gene ID" value="Dthio_PD3728"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421045at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="443" mass="49958" checksum="9F3C382C6786132A" modified="2010-08-10" version="1">MLKKIKSFLQSDIWRLDVQELSRAKAFMTHHLRVFLAALQGFSRNDCSMRASSLTYYTLLSIVPVMALAFGIAKGFGLDDMLQSQLEQYLGAHEEIFDEVVQFSYSMLEVTRGGVIAGVGFLFLLWAVIKVLDHIELSFNAVWGVQEGRSWVRKFTEYLSVMVLAPVLVILSGSLTVFLTTEIYKYLAEGWLALVADLFQWGAQFTPYVIIWLLFTFLFMAMPNTRVNFKAALIAGIISGTMFQLLQWGYVNFQVGVVRYNAIYGSFAALPLFLVWLQLSWMIVLLGAELSYAYQNVRRYIYSSEIQDISPGYKEKVSLLVMHLIIKRFIADKGGVSREEVCEELKLPVTLVNQVLKDLYRAGLVVRVEVSGDEAFKYQPGKDVNRLSIAFVIKTLKDAGSSDVPVVHNLAWDRISSALESFEETIKHSPDNVLLKDIGAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK65</accession>
    <name>D6SK65_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="9" type="ORF">Dthio_PD3731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869387.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3731"/>
    <dbReference type="EnsemblBacteria" id="EFI36268">
        <property type="protein sequence ID" value="EFI36268"/>
        <property type="gene ID" value="Dthio_PD3731"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="432" mass="48966" checksum="BF92AD219C2B0222" modified="2010-08-10" version="1">MSLELKKIIDQISKDKGIDRDMLVDTLEEAVRSSVYKKYGSNLDIEVNFNEDNGEIEVYQFKVVVDEIGDPNNEILLEDAKEHDPNVQLEDELGFTLDVKDLGRIAAQSAKQVLMQKMRDAEQEIIYEEYKDRIGEIISGIIQRRDRAGWIINLGRTEALLPRDEQIPKERFHRGDRVEAYIIDVRRESRTPQIIVSRSHPEYLISLFKREVPEISDGTIKIMNVVRDPGKRAKVGVMTKDMDVDPVGACVGVKGSRIHNIVQELKGERIDIVIWSPDIATYAANALSPARITRITVDEDEKSLEVVVPDDQLTPAIGQKGQNVKLASSLLGWKIDVYTESRYNEVYEHHQVMEQLASAAGISISEFNREGFDSLDSLVQSTDEELKQKLDLSDENLESLKGAINFLGPQKLNLTGEEPLLQEKKPEQNDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK74</accession>
    <name>D6SK74_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3740"/>
    <dbReference type="EnsemblBacteria" id="EFI36277">
        <property type="protein sequence ID" value="EFI36277"/>
        <property type="gene ID" value="Dthio_PD3740"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Raco_middle" evidence="2">
        <location>
            <begin position="115"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="RACo_C_ter" evidence="1">
        <location>
            <begin position="265"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="508" mass="55593" checksum="4EA0E7B124FEE9C0" modified="2010-08-10" version="1">MMQVTRMRVLQNNARREIKPDPAAPLSLNLFQHGFLAGVPLCSGLGLCGGCRVLFHSGAPEPSDKDYDFFSPEELSRGYRLACAHFPDADMVLEIPRQQKPEKSEWQSRAAPVAAGVDLGTTSIKWGFAHDRGGPSTGTVLNPQMGSGSEVMSRLAYARESREHFQQLQDLLLQELQRILELSPESIPACITGNPAMIHLLLGLDIAGLAGHPYHLGGPAGDFFALPGIRQRVFIPPLISPFVGADISSGLTCLILQEKATFPFLFFDLGTNGEMVLGLGPGEYFCTSVALGPALEGVGLRFGSAFGDGVASGFDFTQKGIQPDIADWNGLVSGSGYLSLASLLLRLGCMDDKGSFKRPQTRVADKVHVQNNRVVLGKNFFLGGRDVEEMLKVKAAFTLGLEYLLEKTSMTMDQVPRIYMAGALGEHFRLQDLEELGFLPRGAFHKCRVAGNTSLKGALMLARDQEARNWVQKLPQKMRSLPLAEDRDFFNTGFFRHMRFQFTPANQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK82</accession>
    <name>D6SK82_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multi-sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869404.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3748"/>
    <dbReference type="EnsemblBacteria" id="EFI36285">
        <property type="protein sequence ID" value="EFI36285"/>
        <property type="gene ID" value="Dthio_PD3748"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="244"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="322"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="378"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="608" mass="70213" checksum="37D66CFB75CB6D84" modified="2010-08-10" version="1">MKNTPEAENTGLRNSLRSRMAIWIAALACLFALAGAGISLAVGFNLLDRDFQRNVRSHMQLASISLKAPVRQIDYLELRDQVQAILDYQGITGVRIMDHNREILHEDGEFTRTILQEDITSGQETLGYIEVSFSRDSLLSNMLFIFYTGLGLLLLLVPGFIFLTWRLSGYYLQDLSHLTRCIKENTCQELPQYPGLQRKDEVGLLAWALKHRDQDLTRYHLELDNYKNHLEDMVEKRTQELKRSQMLKQTILNSIPDAIALINTADLTIQDVNTAFLERFGLERSQVLGRHCYNIMYGYQEPCHHYDMLCPINEYVQHGKPCVTEHRHYNHKNEIIHVEVAAWPVFEENGHVEQLVHVSRDITQKKKVEELREDVERIVRHDLKTPLNGVIGMAELLTEDEDMNSEQREFAGHILESGRRMLHMINHSLDLYKMEEGTYQMRPESFDLQELLQHLRQETSRIRKYKDLQLNFFLNGEPLQEDRQIPVLGEKTNIQSMLANLITNAIEAAPESSQVTVSIQQYAEYMHIDIHNYGTVPQEIRERFFERYATSGKTKGTGLGTFSARLIARSHGGDIDFSTSEDKGTHVRVKLPLTPLDHQLDRTADMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKA6</accession>
    <name>D6SKA6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3773"/>
    <dbReference type="EnsemblBacteria" id="EFI36309">
        <property type="protein sequence ID" value="EFI36309"/>
        <property type="gene ID" value="Dthio_PD3773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="55" mass="6270" checksum="E58B143909D2FEAD" modified="2010-08-10" version="1">MAVLPCLVLAGKVSSEVQEVIRSRPELFAELIKKLKNMPDHAVLRLVREVRDGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKF1</accession>
    <name>D6SKF1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869473.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3822"/>
    <dbReference type="EnsemblBacteria" id="EFI36354">
        <property type="protein sequence ID" value="EFI36354"/>
        <property type="gene ID" value="Dthio_PD3822"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="349" mass="39744" checksum="BC9729B9CE40BDED" modified="2010-08-10" version="1">MKILVTGTAGFIGFRLALALVEKGFEVVGLDNINDYYDVQVKYGRLRESGFQEPYDYGRLYHSDKYPGLSFIRQNLEDREGMQRLFQEQGFSRACNLAAQAGVRYSLTNPYAYVDSNLVGYINLLECCRHNQVEHLVFASSSSVYGLNETQPFSVHANVDHPISLYAASKKSNELMSHTYAHLYGLPCTGLRFFTVYGPWGRPDMALFLFTRAMLEDRPIDVFNHGRMQRDFTYIDDIVEGVIRVLDNPPAGNPHWDPKNPDPASSSAPYRLYNIGNNNPVQLMDFIQALEKALGKKAQKNLLPLQPGDVPSTYADVDDLVRDLDYKPETSVEEGIERFVKWYRDFFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKQ5</accession>
    <name>D6SKQ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868399.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2677"/>
    <dbReference type="EnsemblBacteria" id="EFI35266">
        <property type="protein sequence ID" value="EFI35266"/>
        <property type="gene ID" value="Dthio_PD2677"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10666" checksum="8A435D9E98EBEA4F" modified="2010-08-10" version="1">MTWTVIYHQDVEEDLLSLGPAMAGRVVRAIDSKLTRAPLDFGLPLSGNLTDFRKLSVGDCRVVSRVFQEQVYVLAVGPRRDKEIYRMAGTRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKR9</accession>
    <name>D6SKR9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868412.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2693"/>
    <dbReference type="EnsemblBacteria" id="EFI35280">
        <property type="protein sequence ID" value="EFI35280"/>
        <property type="gene ID" value="Dthio_PD2693"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033H9W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="83" mass="9477" checksum="78FC3ACDF6D9D302" modified="2010-08-10" version="1">MRQNLTISRKGQVTLPAELRRKYGLEAGGTVIAEDRNGELVLRPAAVLEIEIYKDEDIALWDAEDRLDEQTRRLIKEKAGIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKT6</accession>
    <name>D6SKT6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2711"/>
    <dbReference type="EnsemblBacteria" id="EFI35297">
        <property type="protein sequence ID" value="EFI35297"/>
        <property type="gene ID" value="Dthio_PD2711"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05252">
        <property type="entry name" value="CDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013445">
        <property type="entry name" value="CDP_4_6_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02622">
        <property type="entry name" value="CDP_4_6_dhtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="12"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="373" mass="42238" checksum="D200FC6D5DA8FF7E" modified="2010-08-10" version="1">MNTKFWDSKRVLITGNTGFKGSWLTLLLQSLGAEVIGFSLPPPTEPSLFELSRADHGIVMVYGDIRNRSVVQETMDRYRPQIVMHLAAQSLVRASYENPVETYDINLMGTVHILDAMRNTPGIKAAVMVTSDKCYENQEQDRPYREEDPMGGYDPYSSSKGCDELIISAYRRSYFSNNNTALASVRAGNVVGGGDWAKDRLVVDAMQAFMHGKPLVLRNPDAVRPWQHVLDPLYGYLMLAEKMWEHGASYASAWNFGPGRESSQSVSQLANMLCRFWGNGACWVSDKVPSDQHEANLLLLDARKAEMNLDWYPQMDAATSLAWTVEWYRAYSKGADMREFTLQQLSDFAALSRFYPNHEPPKNKKYGFYPDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKU5</accession>
    <name>D6SKU5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2721"/>
    <dbReference type="EnsemblBacteria" id="EFI35306">
        <property type="protein sequence ID" value="EFI35306"/>
        <property type="gene ID" value="Dthio_PD2721"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9SC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="308" mass="34917" checksum="BDEE009A5D5907EC" modified="2010-08-10" version="1">MDRILLGDNQFFAVNHLSEEKARTQAIRFQKDKAILDVLDNALNLGITTFMCTTHDRMSDICRIIRKNPDKYYNLKVYPCMPYAHKYANAVTELGTVGALKEYMPGGLFSTLTRGGWAYLNKDFITMMQLLIDVEMKMFTGLKTPVIFLQNVLTDLLLGLGMKDVLKAFHEYISSKFHAEAGYITMNLPRLLDVLEDAKIENPIICSSINKIGFRMCGGKDLYEQTIASGRFRPVAMQVLAAGALKPREAFEYVCSQPGIESILFGASSKEHIRESRDMILEMSRGWNHERWEPGMAFRENAVADICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKY1</accession>
    <name>D6SKY1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-oxoprolinase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">3.5.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868474.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2757"/>
    <dbReference type="EnsemblBacteria" id="EFI35342">
        <property type="protein sequence ID" value="EFI35342"/>
        <property type="gene ID" value="Dthio_PD2757"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1018930at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_B" evidence="1">
        <location>
            <begin position="4"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="525" mass="56706" checksum="E083F2771FB8D100" modified="2010-08-10" version="1">MTINPILLEVFKNRFSSICEEMGMVLTRTAFSSNIKERRDLSCAVFSPQAEMIAQAAHIPVHLGSMPLSVQAAVQDTELDEIQQGDMVMLNDPFQGGTHLPDITLVAPVFAGGDRPLFFVANRAHHSDIGGMSPGSMPLSTSLYQEGVIIPPVKIMRRGRMEKQIFRLLLKNVRTPGEREGDLSAQVMANFTGIARLEEIIDRYGPELVHNYGQALIDYSERMMQETISSIPDGTYRFEDCLDDDGQGAAGIPLRLELSVQGSTAGLDFTASADQVTGSVNAVRAITMSCALYVLRCLVNEDILANSGCLRPVKVHTRPGSVLDALHPGAVAGGNVETSQRIVDVILGALSRAIPERIPAASQGTMNNVTIGGVDPRSGRAFTYYETLAGGMGASCRHHGESGVHSHMTNTLNTPVEALEHTYPFRVLAYGLRTGSGGRGRFCGGQGIYRHMQVLVPCEVTVLSDRRRTGPYGLKDGRQGMPGENRVRLDGQWHSRPGKFREVLSTGDELIISTPGGGGYGAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL58</accession>
    <name>D6SL58_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868551.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2839"/>
    <dbReference type="EnsemblBacteria" id="EFI35419">
        <property type="protein sequence ID" value="EFI35419"/>
        <property type="gene ID" value="Dthio_PD2839"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335GA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8545" checksum="966173860E42622E" modified="2010-08-10" version="1">MKRMNNDPDMLEEYDFSGGVQGKYSKRYAQGTNVVVIDPDVAEYFPDNESVNEALRGLTAIIKRQKRAEAGHGEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL67</accession>
    <name>D6SL67_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Outer membrane insertion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868560.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2848"/>
    <dbReference type="EnsemblBacteria" id="EFI35428">
        <property type="protein sequence ID" value="EFI35428"/>
        <property type="gene ID" value="Dthio_PD2848"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514956at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087966" evidence="6">
        <location>
            <begin position="23"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="49"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="258"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="661" mass="75961" checksum="2E8EDFD9649CF08C" modified="2010-08-10" version="1">MKKALVFLMMGVFLAGTTAAWAQEEPAQAEEVMMDEVVVTATRFERETEKVPAKVTIIDREDIEKSGAHNVPEVLRNLGGVHVRDMDGNRMNQTLDMGGFGEGSQHRTAVLINGRRLNPVDLSNVRWSTISLDMVERIEVMHGGNAVLYGDNAMGGVINIITRRPEEGVQGDVEASVGSFDTFGTRAAVNMGRDRFGMVVGVNHYQSDGYRDRSEVENYGLFTRLEADPTDALRIYGEVDANKAEYEIPGALTRQQKRDDRKQAQPDDPAWGIFREDDKTNDQDLALSFGLESDVSEYGILDMQFTYHQQDRERTMDGLYSEFDINTWGFTPKYILDRPLGKMDNRLTLGLDFYRTEYDADFVDMGNEFDHVQRSWSGYLQNELELLDNLVLNLGARYQDTDYRLKKKGLSRETTGDPEWAWNAGLAYSFWEHSKIYARAYQAFRYPLVDEYMILSTGDVNMDLEHETQQGYEAGVGWDFRNVLQLDLRGFYFTVDDEIVYDNIKEMNINLNETEHKGGDLDITYKVMDKVRLFASVGYIDAKITSGDHDGNTIPLVPEWKGHAGVELGRFNGILFGLQSNYVGERYYGNDYDNVLDKMSSYNTWDAYLSYKRNQWEFFGHAKNLFGETYSDEAFYNEWDDRYSYYPQPEEEYMVGVRYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLA6</accession>
    <name>D6SLA6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868599.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2887"/>
    <dbReference type="EnsemblBacteria" id="EFI35467">
        <property type="protein sequence ID" value="EFI35467"/>
        <property type="gene ID" value="Dthio_PD2887"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033BU4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1536083at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="199" mass="23033" checksum="CC488ED3C8317259" modified="2010-08-10" version="1">MIIIDGHQTDFNVSNFNNLEDLLVKVIKDRDLGERVVTDVLVNEESFSEIYPHQAEDVDTSDIEKVEIRTMDSITMAMNITRELYKVVTLMSKGGSEVAELFRQGEETRALEMYQDLLSVVRDFMNTVTVLKQDYQLTSQEDLDKGIEKLSELFSEMIEVQEKNDWNLLADLLEYEFLPLVDTWKKIVSELRAEVRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLE3</accession>
    <name>D6SLE3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868636.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2928"/>
    <dbReference type="EnsemblBacteria" id="EFI35504">
        <property type="protein sequence ID" value="EFI35504"/>
        <property type="gene ID" value="Dthio_PD2928"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="732251at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="570" mass="60722" checksum="B860FB4221AFAA51" modified="2010-08-10" version="1">MSVGFLALLAAIPIAIALVLMAGLRWPATKAMPVAWLATALAGIIFWQLPVGYVAALSIEGIIGAIGILIIVFGAILILMTLRDSGGMETIQAGMQDVSPDMRVQAIIIGFLFAAFIEGAAGFGTPAALAAPLLLALGFPALAAAVICLTFNSVPVTFGAVGTPVILGLGPLDDFVTRAVESGAETLNFSDPTTFGIVVGQWSSLMHLPMAIILPIFMLGFITRFFGPNRSWSDGFGAWKFCIFASVAFAIPYVLLAWLLGPEFPSLVGGLIGLGIVVWGAKQGIAVPKDVFTFGAQKDWDPEWTGTVSVAEGSKFEARMSQFKAWSPYILIGFILVLTRLDWLPFKSFLAGITIDFQNILGYEEVANSIAILYLPGTIPFVLVAILTIFIHQMSSDKVKTAWVDAIKRIKNPAIALFFAVALVHIFRGSGVENEALNPNLYPSMPLALAESIAAIAGQTWPFFAGFIGGLGGFITGSNTVSNLLFAEFQWGMASQLDLPHQLIVAAQAVGGGFGNMICIHNIVAVCAVVGLSGKEGLILRKTFWPFMVYAVITGLWVTLMSFVLFPGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLF0</accession>
    <name>D6SLF0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868643.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2935"/>
    <dbReference type="EnsemblBacteria" id="EFI35511">
        <property type="protein sequence ID" value="EFI35511"/>
        <property type="gene ID" value="Dthio_PD2935"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503336M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2069265at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="63" mass="7021" checksum="1EF95F0F9FB771B6" modified="2010-08-10" version="1">MRVSYDEADDILVIRLSNKEITRETSQDWNTHISYAGDGTVVEVVVLDASKQGAWPLLRSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLG8</accession>
    <name>D6SLG8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2953"/>
    <dbReference type="EnsemblBacteria" id="EFI35529">
        <property type="protein sequence ID" value="EFI35529"/>
        <property type="gene ID" value="Dthio_PD2953"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077758at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9070" checksum="CCE72B58FE6C7E19" modified="2010-08-10" version="1">MAGKMLYFNFRKASILLVFFVLLLSVFCAAPTCGDPGDPCICSGFGCSRHSLPTGPEIWEYCAGKQFGVEMLQAVEEWQAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLM2</accession>
    <name>D6SLM2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_37 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868712.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3009"/>
    <dbReference type="EnsemblBacteria" id="EFI35583">
        <property type="protein sequence ID" value="EFI35583"/>
        <property type="gene ID" value="Dthio_PD3009"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1946648at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_37" evidence="1">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10624" checksum="D52FA1351E30E8F4" modified="2010-08-10" version="1">MSNNHFESVWDAIEDTPEQAENMKLRSVLMMAISEHIQRNEISQSQAASLFGVTQPRISDLKRGKINLFSLDSLVNMAVTAGLRVEIKVHDLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLN6</accession>
    <name>D6SLN6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG domain protein DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868726.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3025"/>
    <dbReference type="EnsemblBacteria" id="EFI35597">
        <property type="protein sequence ID" value="EFI35597"/>
        <property type="gene ID" value="Dthio_PD3025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046257">
        <property type="entry name" value="DUF6290"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19807">
        <property type="entry name" value="DUF6290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8756" checksum="8322C0D4E9BF4801" modified="2010-08-10" version="1">MKTITINVSSETYHAFQEYAAQNNRTASELIRNAMEEYRRSYLREDQSIFDAPPANAGSILKDLTPEDDLLQEMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLP2</accession>
    <name>D6SLP2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphomannomutase</fullName>
            <ecNumber evidence="12">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD3032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="12"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868732.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3032"/>
    <dbReference type="EnsemblBacteria" id="EFI35603">
        <property type="protein sequence ID" value="EFI35603"/>
        <property type="gene ID" value="Dthio_PD3032"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256504at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="9">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="10">
        <location>
            <begin position="163"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="11">
        <location>
            <begin position="255"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="8">
        <location>
            <begin position="371"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="455" mass="51037" checksum="260C0CFD283E6FCB" modified="2010-08-10" version="1">MKEIRQDIFRAYDIRGIVDKDFDPEWVEVLGKACGTYFRRMGLDQAVVGHDCRHSSPEYQARMIEGLNSTGVDVVFLNMVSTPLFYFAVKKLERRAGVMITASHNPPDFNGFKVWAEESTIHSEEIQEVYRIMASGEFAQGNGMATEMDIRPVYREYMQAQGPAASKVKVVVDGGNGAAGLDCVQVLEDAGADVVPIYCEPDGNFPNHHPDPTVMKNNEDLVATVKKENAQLGIGLDGDGDRIGVVDENGKMIYGDQLLAIYARDVLQQNPGACVIGEVKCSHLMFNDIKKHGGRPIMWKTGHSLIKAKMKEEDALLAGEMSGHMFFADRYYGFDDAVYAARRMVEIVAKKQGQPVSGYLDDWPKTVNTPEIRVECPDSIKFDVVKKAQEYFRQHYDIVDVDGVRIAFDDGWALLRASNTQPVLVLRFEAESEARLQELRELIEKPLKNWVQELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLY1</accession>
    <name>D6SLY1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868821.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3121"/>
    <dbReference type="EnsemblBacteria" id="EFI35692">
        <property type="protein sequence ID" value="EFI35692"/>
        <property type="gene ID" value="Dthio_PD3121"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1970423at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="2">
        <location>
            <begin position="45"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="87" mass="9473" checksum="B541E0E2A827F237" modified="2010-08-10" version="1">MAEELPAGCARPTGGPVGEEPSEENAEETGMETGSKKEHKKMIQVGRKAPDFTAPGYQQGKFVNVSLSDYLGKWVVLCFYPGDFTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM66</accession>
    <name>D6SM66_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative solute symporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868906.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3212"/>
    <dbReference type="EnsemblBacteria" id="EFI35777">
        <property type="protein sequence ID" value="EFI35777"/>
        <property type="gene ID" value="Dthio_PD3212"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029157at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019886">
        <property type="entry name" value="Na_symporter_ssu_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13937">
        <property type="entry name" value="DUF4212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03647">
        <property type="entry name" value="Na_symport_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4212" evidence="2">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9835" checksum="92A185E3E77F8C79" modified="2010-08-10" version="1">MSKSFEEYWKKNLTLIGILLAIWAFVSYGLGIFLVQPLNNFWIAGFPLGFWFAQQGSIYVFVILILVYCVLMNKLDRDYDVDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMA6</accession>
    <name>D6SMA6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868946.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3252"/>
    <dbReference type="EnsemblBacteria" id="EFI35817">
        <property type="protein sequence ID" value="EFI35817"/>
        <property type="gene ID" value="Dthio_PD3252"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="109"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="342" mass="37919" checksum="2723FD10D468562C" modified="2010-08-10" version="1">MDFFKHKEQAIRTSRYLVFLFILGTIGVLAIIYLFIFGYFIFSYGTVEQAWMAMNIYRTEMVVLGGVVALVIVGGTLFQVSRLSKGGSVVADILNARLVSPQTRNSNEQKALNVVHEMSIASGLTKIPKLYVMDGEDSINAFAAGWHEDDAVIGLTSGAMERLSRSELQAVVGHEISHIQNGDMYLNIKLMGIIFGLLILTYMGSFVIRKAFYGSMISGNRSRTDPRALIVILILGAGLIMAGVVGMLLGNIIKAAISRQREYLADASAVQFTRMPQAMEGALIKIRDMSRTKNKNHLNNPNAEQASHMFFTEAVSKFESLFATHPPIEDRIRRINPDFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMF0</accession>
    <name>D6SMF0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868990.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3300"/>
    <dbReference type="EnsemblBacteria" id="EFI35861">
        <property type="protein sequence ID" value="EFI35861"/>
        <property type="gene ID" value="Dthio_PD3300"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="833439at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="244" mass="28830" checksum="60F354BF376AB36B" modified="2010-08-10" version="1">MSKYIEQIKKLVSLQEIDTELIQLKNRMEEAPRHLENLQNELKNLEEQKYHIEERVKLLSEQKKKLQSDIDQDGDKIKKSKNKLMMVSNTKEYHAMMREMDNLEKLNRFREEELNNLLEDLQAQQAKKEELNNQFQSLQDELATTQATLDSELQQIQERIQELENDREKACADVPVPILSRYNFIKDRLHNPVIVSVRQSVCTGCFISIPPQSFVEIQKGEQILSCPNCQRLIYWEEHYSGNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMG8</accession>
    <name>D6SMG8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3318</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869008.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3318"/>
    <dbReference type="EnsemblBacteria" id="EFI35879">
        <property type="protein sequence ID" value="EFI35879"/>
        <property type="gene ID" value="Dthio_PD3318"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="252"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="315"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="380" mass="42905" checksum="829AAFFA145FE281" modified="2010-08-10" version="1">MFGKSLNLFKIFGFQIKVDVSWLIIAVLVTWSLAVGFFPHFIEDLSPMGYWILGVIGALGLFFSILFHEFWHSWVARNYGVPIRGITLFIFGGVAEMEDDPQSPKSEFWIAIAGPLASIFLALVFFVLYNAAQFMELGAAGIILFMYLALINTILAVFNLIPAFPMDGGRILRAVLWKWKGDQRWATRIAANMGSMFGLVLIGIGILNMLTGNVVGGLWYFVIGIFIRYVAQNAYRQMMIKSAVAGARVRSLMKRPVYVSPDITLARLVEEYIYQFHFKMFPVVDQGKLLGCITTRQIGSIDRHQWGDTLVRHVYIPCSDNNTIHPNTDILYALNRMNQEGQSRMMVVDNGILMGMISLKDIMGYLSARMEIEGDRSFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SML0</accession>
    <name>D6SML0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S5A_REDUCTASE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3362"/>
    <dbReference type="EnsemblBacteria" id="EFI35921">
        <property type="protein sequence ID" value="EFI35921"/>
        <property type="gene ID" value="Dthio_PD3362"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="DUF1295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="PTHR32251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="S5A_REDUCTASE" evidence="6">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="33078" checksum="E2FAA681D55B759D" modified="2010-08-10" version="1">MYNNFNIRINTCTDLNTMPLHTIILLNLAAVMLLMLAAWILSLARDKACVADSFWGAGFVLIAWLTWFMGPETFRSLLVALLISIWGIRLILHITRRNWGQPEDRRYQAMRDYHGESFRWISLFKVFMLQGSLLWIIALAPQVAQASPRPGELVWLDFLGIFIWALGMLFEVVGDYQMSQFKKDPSNRGRVMDRGLWGWTRHPNYFGECLVWWGIFCIALSVPGGWMTIISPLLITFLLVRVSGVAMLEKDMGSRRPEYENYKKRVSAFVPWFPLKNKEAGDHEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMN9</accession>
    <name>D6SMN9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869078.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3392"/>
    <dbReference type="EnsemblBacteria" id="EFI35950">
        <property type="protein sequence ID" value="EFI35950"/>
        <property type="gene ID" value="Dthio_PD3392"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1595361at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="5">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="158" mass="17146" checksum="89410F056253DE05" modified="2010-08-10" version="1">MGDELTHVDKQGHVGMVDVGSKQETGRKAVVRSVVRLASSTMHMLMKQALPKGDVLVTAKLAGIMAAKKTGELIPLCHPLFLSYVDVRFDVQQDENRIVVEAEARTTAATGVEMEALVAAQTACMTIYDMCKAVQRDIVIEDCRLVHKSGGRSGTYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMP2</accession>
    <name>D6SMP2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PP-loop domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869081.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3395"/>
    <dbReference type="EnsemblBacteria" id="EFI35953">
        <property type="protein sequence ID" value="EFI35953"/>
        <property type="gene ID" value="Dthio_PD3395"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1051352at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="27841" checksum="A3F6E956EE5292FF" modified="2010-08-10" version="1">MGIKKNLNHAQKICLGRCGKLMQQTGMLWPGARVGIAVSGGVDSWVLARVLMIRQKIVPFYFEIILLHVNPGFDPGNHQPLVDWLGANPLPGHIQSTDIGPRAHNPGNTKSPCFLCSWSRRKVLFDLCRKYSLTHLALGHNAEDLAATFFMNLIQTSRVDGLSAREEFFQGSLTLIRPLLLVEKKYIRNAARRWELPVWENPCPSAGASKRTEMEGMLDVLSGGNKKTRQNILNAFKRWQLDLACNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMQ2</accession>
    <name>D6SMQ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869091.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3405"/>
    <dbReference type="EnsemblBacteria" id="EFI35963">
        <property type="protein sequence ID" value="EFI35963"/>
        <property type="gene ID" value="Dthio_PD3405"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192930at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11035" checksum="BC7D6FEA1F64DE8F" modified="2010-08-10" version="1">MVSPLSLPVVMAQSYIAQHFQVAAHNSPARHQAVLSDIAVRKFAHEKGQVSATDSISQLAAQKEHQGSKHLGPEKTSPRRKKSGDQEKPDPFSDNIVDIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMQ9</accession>
    <name>D6SMQ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase Obg</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">obg</name>
        <name evidence="8" type="ORF">Dthio_PD3412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869098.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3412"/>
    <dbReference type="EnsemblBacteria" id="EFI35970">
        <property type="protein sequence ID" value="EFI35970"/>
        <property type="gene ID" value="Dthio_PD3412"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="7">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="162"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="313"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="339" mass="37474" checksum="9C7F8123B7FC2C52" modified="2010-08-10" version="1">MRFVDEAEITARSGKGGDGCVSFRRERFIPRGGPDGGDGGEGGSLYVEADPGLLTLYDFKRKRLFAAQNGRPGMGRQRFGRSGDDLVIYLPVGTQVYSMQEDGESLLADLVHPGQRVLLAQGGRGGKGNTHFKSSTMRAPRFAQPGEEGVELRLKLRLKVLADAGLLGLPNAGKSTLLSRISAARPKIGSYPFTTINPNLGVLRDQRDTQMVVADIPGLISGAHQGRGLGDRFLKHVERTRFLVHILSVEDIDLDSPWQGFEILNQELEKYSPELASREQVLVLNKTDLLSRDELDKLGRAVEAYEYRVYLISALEGTGVEKLVQDMWERFYRLSVDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMV8</accession>
    <name>D6SMV8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA modification enzyme, MiaB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869147.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3461"/>
    <dbReference type="EnsemblBacteria" id="EFI36019">
        <property type="protein sequence ID" value="EFI36019"/>
        <property type="gene ID" value="Dthio_PD3461"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="128"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI36019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="429" mass="48788" checksum="D026F7CA68AEDE0A" modified="2010-08-10" version="1">MSSAYFFMTTLGCRVNQYESQAISEALQRQGLVPADGPEQAGYIYVNSCAVTARAVKDLKKTLRRLRVQAPQARIIVTGCAAQIFEEELGALEEVDLVVPQSRKTSILASPFPDPHAGDPGLDYWITSYFRARPVVKVQDGCSRGCSYCIVPASRGAPVSRPPEVVLREIQGLLNRGYREIVISGINLGMYGVDLDAREDFWDLICYLEKNLASEWEDRMRLRLSSLDPAMLDSRGIDIISSSVLICPHFHLSLQSGCTWVLTRMGRDHYHPAKAIFFVERLERTIPFYSMGADFLVGFPGEKPDYFERTLKLTEALPLSYGHVFTYSPRPGTRAARWPDQIAQHVKEKRARELKEVLKHKRQRFTSKLLREDKLRLIMETPYKGMSEYYMDCFIEDQNLGLKPGDTVSAAPYKIQDSKLMVEVFSQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN15</accession>
    <name>D6SN15_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36076">
        <property type="protein sequence ID" value="EFI36076"/>
        <property type="gene ID" value="Dthio_PD3523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="35" mass="4012" checksum="7251AD988A62BD0B" modified="2010-08-10" version="1">MQENLLSQADYITDQSGNIKSVVLDYQTLKKLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN34</accession>
    <name>D6SN34_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869220.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3543"/>
    <dbReference type="EnsemblBacteria" id="EFI36095">
        <property type="protein sequence ID" value="EFI36095"/>
        <property type="gene ID" value="Dthio_PD3543"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432299at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021301">
        <property type="entry name" value="DUF2779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11074">
        <property type="entry name" value="DUF2779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2779" evidence="1">
        <location>
            <begin position="293"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="485" mass="54697" checksum="0B1F756685F9B166" modified="2010-08-10" version="1">MTHRLSKSKILSGIQCPKRLWLEVHKSDLLEYDQNTLARMQTGHKVGEIACQYLAPGGVYVGLEEGFGHALKLTREHLDSSDLPIYEATFVHDQVIVRTDIVLPGKSGLKMIEVKSSTSVKDYHIWDCAVQSWVLQGAGRPVLEIEMAVIDSSFVYPGKGDYQGLLRTEDVTKAAFEMRTQVEGWVGQFLKTLQEPIPAIEMGDHCRSPFECPFMDFCSPANRPGYPLQCLPRVSTQLRQELIQEGFDDIRDIPEGRLTNPNHERVRRITLSGEAEFMPEKAVHIKAFPYPRYFLDFETAQLAVPVWEGTRPYQQLPFQWSCHIQDRPGQIRHEEFLDLTGDPPMRGFAQSLLLVCQEAGPIFVYGSFEKTIIHGLIQHLPDLAGSLQALSDRVVDLLPVMRQCYYHPEMRGSWSLKAALPCIAPDLDYSALPGIHDGGQAQEAYAEAVAPGTTPERKEELRRGLTAYCEMDTLALVRIVENLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN99</accession>
    <name>D6SN99_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chondroitin 4-O-sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1576"/>
    <dbReference type="EnsemblBacteria" id="EFI34225">
        <property type="protein sequence ID" value="EFI34225"/>
        <property type="gene ID" value="Dthio_PD1576"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HGK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1626243at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="PTHR12137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="269" mass="31130" checksum="133F0BB0CC5CBFC7" modified="2010-08-10" version="1">MSLAYLKYKLGTKRLKNIIHPSIKDGYIYISNPKAACSSIKLYLARCMTNNPEFTPVSLHKRKHLPFDDPGNLTNDNLERLFNGNYFVFTFVRHPLKRVVSAYGDKIAGNRFQKKEILALLGNNPDELEKPVSFDEFVKAITSQKPEKLNPHWRPQVHNLYPNIIKYNFIGHLETFDTDFNYVRNKLNLPVFPVKRQNVKSFKAEPEALLNPFNRFRLARLYAKDFVRFGYRPQGIEYLGVLLGYLPGNTGLMLRRGKKLLTKLIPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNG6</accession>
    <name>D6SNG6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869620.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1643"/>
    <dbReference type="EnsemblBacteria" id="EFI34292">
        <property type="protein sequence ID" value="EFI34292"/>
        <property type="gene ID" value="Dthio_PD1643"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="313" mass="35997" checksum="C29234DDB68D04DC" modified="2010-08-10" version="1">MAHVAGTREYLDKLVSLPRPGEENIFAFYDHRLEMICKDPRMMLIPLDDHMIHRGDGVFETVKYLGRRVYQLEAHLERMEKNCRAIFIRPPLSWEHIREMVLETARAGGQDDGYLSLFIGRGPGGFAIDYRECPWPSLYIVARRFNYLPESMWEKGVRACKSEHPAKPSFMARIKSVNYLPNVLMKKEAVDKGCDFVLCFDQHGFLAEGCIENVVVVDQKGRILVPELNNALPGTTLMRALELIKDEMTFVFRPISEEEIYEAREVILLGTTLDAMSIVRYNGKPIHDVRPGPVSKRMRELLVRDLEENGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNL7</accession>
    <name>D6SNL7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3343 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869671.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1694"/>
    <dbReference type="EnsemblBacteria" id="EFI34343">
        <property type="protein sequence ID" value="EFI34343"/>
        <property type="gene ID" value="Dthio_PD1694"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503015V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1438403at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="181" mass="20280" checksum="38A549FDAD335117" modified="2010-08-10" version="1">MNFLKSIFGKAKKTRGVSERGILVFHHTSEVIEAESHLSEAGLDVRVMGPPPEIQTGCDMVIEFPIMHQLQALDILEQKRIKPIQVTAAQDHLLEPVSLYNIRDFGDFLMVRAANMKITVDRQSLKIVNVSGGGCPDVPFLAEQLVGRPLHEAPEPRRFGRTLCGYSLQLAYEEMKRRCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNP5</accession>
    <name>D6SNP5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1723"/>
    <dbReference type="EnsemblBacteria" id="EFI34371">
        <property type="protein sequence ID" value="EFI34371"/>
        <property type="gene ID" value="Dthio_PD1723"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088128" evidence="1">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="57"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="149" mass="16649" checksum="68AE51C7E1B53365" modified="2010-08-10" version="1">MRKCLWAQFCLVVFLAFVATACTQDDSYNYISPAELKERLDAGEVEQGSLVVFSSQTEEEWESGYLPQAIPTFARPLESDEDYAKLEPVLDKVRGTDADIVVICPRGGSGATRPCDYLMDHGIDEDRLLILEGGQEAYNDEFPEDVVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNV4</accession>
    <name>D6SNV4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipolytic protein G-D-S-L family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869752.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1789"/>
    <dbReference type="EnsemblBacteria" id="EFI34430">
        <property type="protein sequence ID" value="EFI34430"/>
        <property type="gene ID" value="Dthio_PD1789"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008265">
        <property type="entry name" value="Lipase_GDSL_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01098">
        <property type="entry name" value="LIPASE_GDSL_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="187" mass="20400" checksum="78D59EEFA5639E43" modified="2010-08-10" version="1">MITILALGDSLTAGYGLGPGKSFADLLQEALVQEGWQVKVINGGVSGDTTLDGLRRSSGLLRHGPDLVIVELGPNDFFMELPLSEVQQNLDRIVEVCLDSGARVLLAGFESLQGFYPGYAQGFHTVYREISAARQVSFVPDFLPGIPDNPELTLPDGVHPNEEGTRRIVEHILPYVREELSRIKDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP59</accession>
    <name>D6SP59_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ORF">Dthio_PD1907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869855.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1907"/>
    <dbReference type="EnsemblBacteria" id="EFI34535">
        <property type="protein sequence ID" value="EFI34535"/>
        <property type="gene ID" value="Dthio_PD1907"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="155" mass="17906" checksum="E24D734E38009398" modified="2010-08-10" version="1">MSQGKSGIKIIAVNRKVRHYFEIMETMEAGMALTGSEVKSLRAGKVSFKEGYVRFDRGEAYLVDVHIAPYENAGYAQHDPVRPRRLLMHKSEIKRLMGKVEQKGLTVIPTRMYFKQGRAKVEIALARGLRLHDRRETLKRRAVERDTAREMAKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPC0</accession>
    <name>D6SPC0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869916.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1968"/>
    <dbReference type="EnsemblBacteria" id="EFI34596">
        <property type="protein sequence ID" value="EFI34596"/>
        <property type="gene ID" value="Dthio_PD1968"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117731" checksum="F38E18757E825979" modified="2010-08-10" version="1">MPSPPDNSRIASFVGPFLSSYPAPILLFLALALGALAITVTPREEEPQIVVPMADVIVDVPGAGPGEVEKLVATRLEELLWQVQGVEYVYSTSRRDQAVVTVRFFVGQDLEDALVRLHNQIIMHQDQVPSMVQDWIVKPVSIDDVPILNLTLFSNERSDYELRRIGSELLARLSEVENVSRSQIFGGRPRQVQVEMDPQAMSGRGISPVHIQKALEEADFARTLGDFSRDNLQFQVLGDAHLRTAQQVQRLVVGMHEDRPVYLEDVARVRDGPAEPESYTRLGMSGSYMQEKGLVGPFSMPAVTLALAKKQGTNAVQVADSILERMQKLEGLILPEDVEVEVTRNYGRTAQEKVSELFRSLFFAVATVVLVLTLTLGWRPALVVGLAIPVSFSLALFGSYLLGYTINRVTLFALILSLGLVVDDPITNVDNVKRHMGLGGKSPGNAVLAGVSEVVVPVVMSTLAIIACFLPLFFITGMMGPYMAPMAANVPMTVIFSTLCAVTIVPWLCHRFLSRPGIKKGGTGQQGVPHWIMKGYRGLMTPFLQSRWMRRGLFLLVTVLILAALALVLLRMVPLKMLPFDNKDEFQVVINMPEGTTLEHTDAVVRDFEDYLSRVPEITTYTTYTGKASPMDFNAMVRGYYARQDPHQADIRINLKPRQKRDKSSHTLVLSLRRDLEDLARKHGAAMELVEVPPGPPVMATIAAEVYPDPDRTYAETIDAARHVQNIMIQEEFVRDVDISAQARHKRLDFVLDREKASLHGLDARDVLGALGLYIGGSKPAALHSPYERETVHIRMKLPLEKRSGINNLQQLHVIAGNGSAVALKELGRFEKKPVEQPILHKNLRRVVYVTAEMAGQPPGEAVLDMKSRLSEDPLPQGFSVQWRGEGEWKITIDVFRDLGLAFGFALLAIYVLLILQTGSLSLPLLIMSAIPLTLTGIMPGFFLLNLITGKEVDGFADPVFFTATAMIGMIALGGIVIRNSLVLIDFIRSALNRGEDLKEAILQSGAVRLRPIVLTALTTAIGVWPITLDPVFSGLAWALIFGLISSTVFTLVLVPVTFYLLYREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPF3</accession>
    <name>D6SPF3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869949.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2001"/>
    <dbReference type="EnsemblBacteria" id="EFI34629">
        <property type="protein sequence ID" value="EFI34629"/>
        <property type="gene ID" value="Dthio_PD2001"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZT54">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2044980at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="16591" checksum="7CCE727466419AC5" modified="2010-08-10" version="1">MRRLLLCLLMAVPGMMLEYPHIVKAEPAATLNSDHYLHSHFNKFAKSRVDMLNRNYAGTKESPRLKHTENGVVGKYSKAKKDSLTVQVRRTQSELSPFIGVMKYTEVRYKGSGDCSNSITSESFERVRTRSVTEIFRFVQDDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPG0</accession>
    <name>D6SPG0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ORF">Dthio_PD2008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869956.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2008"/>
    <dbReference type="EnsemblBacteria" id="EFI34636">
        <property type="protein sequence ID" value="EFI34636"/>
        <property type="gene ID" value="Dthio_PD2008"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="27025" checksum="EC668925D8E7354D" modified="2010-08-10" version="1">MKPILIDIGGLSIYAFGVFMAAAYLLAMAWGMREAGRKGLDRGMVLEFGFYVLIAGLAGSRLFYFLLYPGEFEGSLIRVLTFWDGGLVLIGGGITGAVALMFYLSLKKQDIRAWLDALAPATALGLVVGWMGCMFAGCGYGRPSQVPWAVTYTHPDSLGPLFVSLHPAQLYHALASLVIFIVLLGLRGRLKSKGQVAGLFLMLYAVSTMAVDFFRYEYEAMLWIFSPVQAVSMVLLVVGLALFVHKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPH3</accession>
    <name>D6SPH3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">Dthio_PD2021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869969.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2021"/>
    <dbReference type="EnsemblBacteria" id="EFI34649">
        <property type="protein sequence ID" value="EFI34649"/>
        <property type="gene ID" value="Dthio_PD2021"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="251" mass="27438" checksum="0183A697A54C21E5" modified="2010-08-10" version="1">MPKKLMAANWKMFKTWEEARQTARELVVAVRNDLPDDREVLLCPPFTALRGVSEMLMQQEGFYLGGQDFYPAEQGAFTGEINPDQLLDAGCSYALVGHSERRHVLGEKDDFLASKVAFGLQKGLKVILCIGETLQERKHGQVQEVLHAQLEHGLKHISTGISAEHLAVAYEPVWAIGTGETAGPPEIQEAHDLVREKLKGILKQGEAIRILYGGSVKPENTASIISLDNVEGVLVGGASLNADKFSQIVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPI5</accession>
    <name>D6SPI5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2033"/>
    <dbReference type="EnsemblBacteria" id="EFI34661">
        <property type="protein sequence ID" value="EFI34661"/>
        <property type="gene ID" value="Dthio_PD2033"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="171" mass="18854" checksum="4D0476398D53F335" modified="2010-08-10" version="1">MVNEPGNQAKRSPRPGVIAGARCFAFRLALFGVIWWGLAGGSLQDWPLGLFFVLAAAVSSMFLVPGQNLRLPGLPGFIPFFLHLSLLGGLDVTSRAFRPSMPLKTGIIMHRVQLEHPTARVLFVWVVSLLPGTASVQLVDQSLRIHVLDAAQPHQDRLKDLEKRIQALFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPK9</accession>
    <name>D6SPK9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="4 10">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="4 10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870005.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2057"/>
    <dbReference type="EnsemblBacteria" id="EFI34685">
        <property type="protein sequence ID" value="EFI34685"/>
        <property type="gene ID" value="Dthio_PD2057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="243" mass="28051" checksum="FED1C258401D646F" modified="2010-08-10" version="1">MHTFYLPPEKWQEPYCLESDEAHHLSRVLRISAGEKIRVLDGRGRLGIFEVRTSSRKEAGLFPENIWRVPKPQTRLHLALGWNKSSRRSWLLEKAVELGVWRLVFWTGKNSQGRMDNASYQNWHKKIVTAAKQSRNPWFPEPVFLSGNVQELVQYARNIPVRIALWEQECQDDLVSLYQAGPEPDRVVAIGPEGGLTQEELQVLMQAGFKPASLGPRVLRWETAALSVLCLDMFFRHREEGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPT1</accession>
    <name>D6SPT1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870075.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2133"/>
    <dbReference type="EnsemblBacteria" id="EFI34757">
        <property type="protein sequence ID" value="EFI34757"/>
        <property type="gene ID" value="Dthio_PD2133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="275" mass="31745" checksum="60BF4313D3E0A74A" modified="2010-08-10" version="1">MPERTHRRSPPGTLDERPLEQPSWTYSDMLEEEELETEDHLDDNQGLEVLEQSPVTGDDLDDELDTQEEDEAALFDLSLDHEYVTAGVEPDIRIIESANSPSGYMYYLFTARLVHYGLSSYQEMYSKFLEKHEFLDKTARFFIEHFREWLDHLGSPEEHKYIPAVSQKQIYKNWGSDSDISTKASELFNHLHIALPGGRIILLKNYLSQAKQEGPSTYSILRETGFLVKSNPGISAAELNKQLTARIRSWNEKWAAWEITDQQAGEYLKKLISQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPT9</accession>
    <name>D6SPT9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein APE2256</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870083.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2141"/>
    <dbReference type="EnsemblBacteria" id="EFI34765">
        <property type="protein sequence ID" value="EFI34765"/>
        <property type="gene ID" value="Dthio_PD2141"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1919362at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013442">
        <property type="entry name" value="SSO1393-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09651">
        <property type="entry name" value="Cas_APE2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_APE2256" evidence="1">
        <location>
            <begin position="133"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="735" mass="84003" checksum="F6F53F2696925821" modified="2010-08-10" version="1">MKPEDVDVLIFTTVGTSLLTNNGYELKKFRQNEKQEEKVCKELTNKLSRKLIWNHIDLKNNPFPAETSSLYAFLQSNPYSEEELKDKYKKVVFIHSPDLSQKEVPRGINGPAVAQGLVDVTRHQFKNLEEEQRWDFENCREISQLDPEDANVFPRATESLFQIVQEQVNAHPEAEVFLNITGGYKGLVPYLTMLGMALGEMVRIFYLFEESPEIIWLPTLPMAFDVMQWRDQRGLLKPFEDPQCTILEPSQKQKLYEALQGTRAVSLLQKNDAQDIVLNPMGNFLKQLYDESKEGQLSSFGYGDQLLDNINDRDLREYLAKNCIPHWRHMSTGDHIPETVEHGRGHVQRLLELAQQFILAAGLELSDEQLFVLISCIWLHDLGHTGDYFQYEGSDGLVQNPEDESSTGKCFCYGDPDMVRVNHNLLTYQLIKDDELVPEDRRVIFPGRFPKKYHRQRLVDSVKYACLYHRRKMPVKGSKEVGAFMVSRGLSDFEQGNEVVEGFPMLAALLRVCDGAENQAERSGSHEYEKVMRWVIKRRVSAMLDMPEFTGALASLCNNRPELFDQGDYFASFQWDSELSTKIKDIQQVQWDGVTTHTGPAIEAEFKSRQPPHYQKHRMLSNTFVVPVKGDDCKKTGSQGLCAFQGSSKHPVIGVYCLANTGRDDSTGFEYNRQTVLDDIMVSLATEFEPVAHLLPFSLAIFLIENGQVYHLCHHEKHDDSCDGGRAGKYCLKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPV2</accession>
    <name>D6SPV2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870094.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2154"/>
    <dbReference type="EnsemblBacteria" id="EFI34778">
        <property type="protein sequence ID" value="EFI34778"/>
        <property type="gene ID" value="Dthio_PD2154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7548" checksum="7CB7C32F079B9AF8" modified="2010-08-10" version="1">MNCPLSWPVLSPDADALFWQSACHLHLNEVEQGRQKAQDLSDFSPGYPFLKKLVKAIEKVEQKHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPW6</accession>
    <name>D6SPW6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2169"/>
    <dbReference type="EnsemblBacteria" id="EFI34792">
        <property type="protein sequence ID" value="EFI34792"/>
        <property type="gene ID" value="Dthio_PD2169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="9995" checksum="BB3868950943FA93" modified="2010-08-10" version="1">MKYSVFHVIPALLTCLASKLLTFESFTMKKQSRSLALASKVIFAAFEILKKNSGELNGREVINQVEQRVDLDEWARSKYDKSGLITIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPY8</accession>
    <name>D6SPY8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylate/guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870130.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2198"/>
    <dbReference type="EnsemblBacteria" id="EFI34814">
        <property type="protein sequence ID" value="EFI34814"/>
        <property type="gene ID" value="Dthio_PD2198"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1660535at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="289" mass="32038" checksum="D81AF520DE859C23" modified="2010-08-10" version="1">MSDNFSFDLLYNYTNRNISRCLDQAQKIQSKYSKTAYPGYSRMVPGEYKEGFFSTLFLDIRESTKRTIDLGPEKTLLSMQALLPSLARIVSELDGFVVEYPGDGIMAHWDGAKLGNVEALKLSIKAAGWMDDCVGRIVNPILADYGIEPLLCGIGVDAGNIIITKVGNPDFISSKAFGPSINQAAKLSSSMFNSGDDVLIGKSVLESSIPRSGLSEYLNPYFSNFYTLLTDIGCYYHLDKLKHHFLLPDPRSKEHCGSFRARTLGQSLGLRFYADHNYYKKKGFGLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPZ6</accession>
    <name>D6SPZ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870136.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2210"/>
    <dbReference type="EnsemblBacteria" id="EFI34822">
        <property type="protein sequence ID" value="EFI34822"/>
        <property type="gene ID" value="Dthio_PD2210"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9KN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1795586at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="246" mass="27902" checksum="8FC2AE30E8F84AF7" modified="2010-08-10" version="1">MTADKFQIGWSQRIRLEWLERTANLVLAGNDKDTVFASLQQDLQDQLSIGGTAKRGNREKVITILMKLWSVPPRHLQDFRNRGLNLLQVLPVKQHLLVHWGMATAVYPFWAGVAEQTGRLLRLQGHVAAAQVQRRIRERYGERETVSRAARRVLRSFMDWGVLEDSGKKGVYVQGRNLPVDTSESMGWLIEALLRAGSRDSASLHSLMHSPSLFPFSFSGSVSLNTYSGLEFMRFGMDEDMVMLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ34</accession>
    <name>D6SQ34_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870174.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2251"/>
    <dbReference type="EnsemblBacteria" id="EFI34860">
        <property type="protein sequence ID" value="EFI34860"/>
        <property type="gene ID" value="Dthio_PD2251"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029150">
        <property type="entry name" value="dCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14827">
        <property type="entry name" value="dCache_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="348"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="448"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="722" mass="79557" checksum="D7EF2243EE2C2BEB" modified="2010-08-10" version="1">MKQLFNLRLRGKIILPLIIALAVLILIIYFLLGRQLAVVSNEFIQRLSENKQAEIQGAMTLATQESEAVSSLFTRMPEVQQAYRTALQGDIDDLRSPESQEGREMLRQDLSDMLDGFKETRDEDLMLHFHLPNGRSLVRIWRDKNAMVDGNWEDVSDDISEFRETVMHVNNTGTPAQGLEVGRGGFTLRNVLPVMGEERDQLGSVEMLIDFDPVVEAAAEGEGEHLLVYMNEDLLDIATRLQDESEYPVLDNRYVQVMGADDRDLERMISADILDTGRTELSVHQEGNYSVAAFPILDYSGDQVGVMAYVLDISREQAMISNLTYTLVGTMALLLLILAGITFYNTNRTILRPLNKITGFASQVSAGNLEQKLQVDSRDEMQDLGHSLQKMVDNLKEKISEAEEKKEQARQETEKAEQFRSEAEEALEQARKAKREGMLQAAGQIEEVVERMTSASDELSAQVEQSSRGAEQQKQRTGETATAMEEMNATVLEVAKNASSAAESSDQARTKALEGADVVKQSVQAINRVQQQAGEMKDSLAGLGKQSEQIGQIMNVIEDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMKATKEVGEAISSIQSGADENIQGMDKVAQLVDESTGLANNSGEALKEIVALAEQAADQVRSIATASEEQSSASEEVNRSMEEISRISQETADVMQQSAQAISDLAQQAQELSELVNRLKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ78</accession>
    <name>D6SQ78_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870218.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34904">
        <property type="protein sequence ID" value="EFI34904"/>
        <property type="gene ID" value="Dthio_PD2295"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2022430at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="183" mass="20736" checksum="BA16C63EF2D41FED" modified="2010-08-10" version="1">MSQEKVKPVGEEQGSNPSFTPDEVSNVKQDMGKVALAVAVLAVFLLIIFYYTVNSKVQEFSEKVEVIEETRTMVQDIDEKVDSEMRDIQADMRQVTQKAEGTADDLQKAEEKISGIEGKVEDMDERIAELEDLPDVVRNMVLGGMLEEISQKADYVGSQVSEEQKEKLEEARRIMDEVRKEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQG0</accession>
    <name>D6SQG0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="9" type="ORF">Dthio_PD2378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870300.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2378"/>
    <dbReference type="EnsemblBacteria" id="EFI34986">
        <property type="protein sequence ID" value="EFI34986"/>
        <property type="gene ID" value="Dthio_PD2378"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="157"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="236"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="545"/>
            <end position="548"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="603" mass="68757" checksum="04D5C6DC2E7596FE" modified="2010-08-10" version="1">MDEARSKLETQPLGWWVRSHGCNDLTLEHDDREVCLMGWVQYRRDHGGLIFIDLRDRDGLTQVVFTPDVSAQALEDAHALRSEYVLAVKGVVRRRPEDMINPNLYTGDIEVAVREFKLLNRSRTPPFLIEDRAEAAENLRLKHRYLDLRRPAVAGNLRLRSQVVHEIRNFLHSSGFTEVETPVLTRSTPEGARDFLVPSRLSQGHFYALPQSPQLFKQLLMCAGMDRYYQVVKCFRDEDLRADRQPEFTQVDMEMSFVEEEGVMSESENMIARLFKEVLDVELETPFQRLDYSRAIADYGLDRPDVRFDLTLKDVTDVVRGSGFNLFARAELVKALRVPGGAELSRREIDEYTDFVGIYGAKGLAWIKIKEDEWQSPIAKFLSREECSGLTEALGLEAGDIVFFQAASPEVVNNSLGYLRLKLGERFGLIPRDTFAPIWIMDFPLLEWDGEEKRWMARHHPFTSPKDGHMDLLEKEPGQALARAYDMVINGQEVGGGSIRLHTREDQERMFKALGMDLEESRNKFGFLLQALDYGAPPHGGIAFGLDRLVMLMAGCSSIRDVIAFPKTQKASCLMTEAPAAVSNRQLRELGIRLREAEKKPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQG7</accession>
    <name>D6SQG7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870307.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2385"/>
    <dbReference type="EnsemblBacteria" id="EFI34993">
        <property type="protein sequence ID" value="EFI34993"/>
        <property type="gene ID" value="Dthio_PD2385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="355" mass="39079" checksum="9CCD1AA9E8FFDDF0" modified="2010-08-10" version="1">MFTSAIAIILVLGLLIFFHELGHFLVARLLGVGVSTFSLGFGPKLFGFVMGKTEYRLSAVPLGGYVHLVGESEDSELPGGFTSQESFAKRPPWQRILVVAAGPVFNFVLAWFIYWGLFFAHGQMQMLPQIGDLADDGPAMEAGLQSGDLVLSINSHEVQYWEDLVQHIQRNEGEPLDLEVQRNSSIKEFTLVPRMAVQENIFGEEIKTPQIGIVASGETETISLGFISAGKEGLSQTWMLIKLTVEGIKKLIERIIPLDTIGGPILIGQLVSEQKQEGMVNLLALTALISINLGLINLLPVPVLDGGHILFYTIEMITRRPLNERMRQVATRIGILFILSLMAFAIINDILRLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQH8</accession>
    <name>D6SQH8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <shortName evidence="12">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
            <ecNumber evidence="4 12">3.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lpxC</name>
        <name evidence="13" type="ORF">Dthio_PD2396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LpxC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="4 12"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870318.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2396"/>
    <dbReference type="EnsemblBacteria" id="EFI35004">
        <property type="protein sequence ID" value="EFI35004"/>
        <property type="gene ID" value="Dthio_PD2396"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428602at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="307" mass="34153" checksum="6D4CE3F6BEA3BBD8" modified="2010-08-10" version="1">MRQQTIKKDVKCSGVGLHSGERVSLHMRPAEEDTGLVFLHKGPDGSKRLVPSPHSVKSTELATTIGNGDVSISTVEHLLAAVSGLGIDNLYIEVEGDELPIMDGSAASFVFLLRTAGIRRQRLPRRVLGLSRSIVYKNGQRWIKAMPYNGLKIKYTIDFSHPMVGSQSYQFEQNPQHFVRSLAKARTFGFLKDVEKLQSQGLALGGTLNNAVVLDEYGIVNPDGLRYSDELVRHKILDFMGDMSLMGISLWGSFEVHCSGHSFNNSFLRFLDENRDDYLHQVDFGGQEIAVPEYEPKAAHQPQPAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQP9</accession>
    <name>D6SQP9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870389.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2469"/>
    <dbReference type="EnsemblBacteria" id="EFI35075">
        <property type="protein sequence ID" value="EFI35075"/>
        <property type="gene ID" value="Dthio_PD2469"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="154"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="311" mass="32921" checksum="3E91EBA24557EB4E" modified="2010-08-10" version="1">MSWKNHLRGDLLLLLTALIWGSAFVAQKVGMDHMGPFMYTGIRFALGALVLTPLILYFGSLRPPSAAGQKSPSILLAGLLSGTILFVASILQQVGIIYTTAGKAGFITGLYVVIVPLIGCLWGFRPGAGAGVGAVLAVTGLYLLTITDGLTISLGDSLVLACAFMYALHVLAIGWMAPRMDVLRLAALQFWVCAGLSLLVGLALEELTWNMVRSAAVPILYGGVLSVGVAFTLQVVAQKRSPPTHAAVILSLETVFAVFAGMIILGEALSPRGWAGCALMLAGMLAAQLDSVYPVKKVLVDRIRRLFKQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQQ2</accession>
    <name>D6SQQ2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 6">Acylphosphatase</fullName>
            <ecNumber evidence="3 5 6">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 5 6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870392.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2472"/>
    <dbReference type="EnsemblBacteria" id="EFI35078">
        <property type="protein sequence ID" value="EFI35078"/>
        <property type="gene ID" value="Dthio_PD2472"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10245" checksum="5F27E14CB773D1BA" modified="2010-08-10" version="1">MNSMHCILSGKVQGVFFRSWTQEQAQSLGVKGWVRNLHDGRVEVLAQGDENALAEFKKRLIQGSSMSEVKDIKCEDMEYDKTYSKFEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQW9</accession>
    <name>D6SQW9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar secretion chaperone FliS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FliS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870459.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2540"/>
    <dbReference type="EnsemblBacteria" id="EFI35145">
        <property type="protein sequence ID" value="EFI35145"/>
        <property type="gene ID" value="Dthio_PD2540"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1730695at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14469" checksum="A07A352B82FD39EE" modified="2010-08-10" version="1">MYSNAARAYFQTKVKTTTKEDLVVQLYEAAIKFLEQAKERIREKDYIAKGERIDRALMIIGELNSSLNAEKGGEVAKNLHAFYASCQARLLMASLKLDIEKIDEVINMLRQVSSAFAEVSRNQKHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR75</accession>
    <name>D6SR75_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARMT1-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870549.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0517"/>
    <dbReference type="EnsemblBacteria" id="EFI33191">
        <property type="protein sequence ID" value="EFI33191"/>
        <property type="gene ID" value="Dthio_PD0517"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="141666at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="SSF111321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMT1-like_dom" evidence="1">
        <location>
            <begin position="219"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="591" mass="69521" checksum="0C9C82352815A479" modified="2010-08-10" version="1">MARLPHISSVSNVYYGQDPHLDAWLLHFMLENNIEHLVNPRVNASAEQLRFMVDIDEGQLFAPCTDWMFANLLQTRMSPDLKKEYLQTWKKLIFLIRNYSSDDFVKKKVLSLCKHILGKVLRSPFMIPSRLHKRMLDIFLSQNTLQDPYRERKCTYNRRALEFMHTPGFFRFISSCPSSTMSCEKIQDLRWELDLLELKRFFCLSTWDSIWQEEDFAPDQQEIEQELSRSWQDFREVMTSLFGPENVYRIKILYLPSQSGGLVYDMQVIKNLIRQGHKVTLALKEGFYYEYPTLWDCYADSVLAHLLSEASFLEESQASKNDFLKKQRENNLVVISDGSRERLNLYRTSVTFSRAWKESDLVIAKGLGNYRRLIQNSCAFTRDILCLFRDEDYEVKFEFKSKSSRVRKITEKEILAKAENIKKQMAEVRRQGQRVLFYSAIIGSIPGQTRTALRVLNTFVDYIRSRMSGTFIINPAEHFEQGMDGDDLMYMWEIVQRSGLIDVWRFQSVRDIEKSFELMGERVPPVWAGKDATFSTGCTKEMHIALDVQKKYPEMQIIGPSPEQFFRRREYGVGKFFDANIEKEPEQYASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRA2</accession>
    <name>D6SRA2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870576.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0544"/>
    <dbReference type="EnsemblBacteria" id="EFI33218">
        <property type="protein sequence ID" value="EFI33218"/>
        <property type="gene ID" value="Dthio_PD0544"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="354"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="8">
        <location>
            <begin position="606"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="8">
        <location>
            <begin position="821"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="972"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1094" mass="122010" checksum="E220A144CB127B7C" modified="2010-08-10" version="1">MNQNKQKENEQMQQAFREEAGDILPELETTLLELEENPDDSELINRAFRALHTIKGSGAIFGFDQLSEFTHEIENAFDLVRSGKMQVSKRLLDLTLQAKDKIHALLYHPETVSRESLDQILKSIEEILPEQGSKSSEDPAQHVQEEDPQGETEVYHIRFKPERDIFATGTDPLMLVDELRELGPIFVAAHHEEIPDLESIDPEKCYVWWDILLASNMGRGAIDDVFIFVDEDSELSIEVLEHPGDAGEENLQTIWEKTFTPSDSSTLDAQNSPQPEKEPEHEQVYQEDEEEDKAREPEVEPETKAPPPPDPQEEKPAPPQAEQKEKSQARPQKTQPDKDKKPQDKQAAQAQTSSMPDSLRVNVGLLENLMNLAGELVLSRNQLMQAISTQDDQTINLAGQRIDLVTSELQEAIMLTRMQPVSNVFNKFPRVVRDMSQSLGKDIELYLEGKEVELDKTIIEGLSDPLTHLVRNSADHAIEKPDERVAKGKKPQGKIVLKAFHAAGQVNIEIIDDGKGIPVERIVEKALDKGLITEEQVRTMSDKDKAQLIFLPGLSTADQITDVSGRGVGMDVVKSNLDRLGGQVDIDTEEGKGTSIRIKLPLTLAIIPSLLISVSQERFAIPQINVDELIQIPAQQVQEKIEVVGDAQVLILRGELIPLVGLNEILRLDQKNTRSKARVTSIEEARSRKDRQDKKAETSAQTSEKSRSEDAGLEKEVIEASKWSISGEEDINIVVVYSGTFKYGLVVDELHDSVEIVVKPLGRHLKACDGYAGATIMGDGHVALILDVVGMARLAELSSMAGTEKAQEMAREQETEKEKDLHSLFLFNNGPREHCAVPLDLVARVELIKAEDIEITGGKKVIQYRGGVLPVFALHEAASVEHLELEGELVVIVFYMAGHEVGLLASPPVDAREVRVEIDDFTLKQNGISGSAVLDGYTTLIVDIYEFMETLNPQWFESREKVQPLEQEGGTQILLVEDSDFFRSQVKKFIQDEGYEVATAEDGAVAWQYMQDNPGEVQLVVTDLEMPNMDGFELTEHIKSDDRFNHLPVLALTSLAGEEDVARGKKVGIDDYQIKLDKEKLLQSIFSFLSSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRB1</accession>
    <name>D6SRB1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870585.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0553"/>
    <dbReference type="EnsemblBacteria" id="EFI33227">
        <property type="protein sequence ID" value="EFI33227"/>
        <property type="gene ID" value="Dthio_PD0553"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="314"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="381" mass="42004" checksum="ECD97397CB8C3378" modified="2010-08-10" version="1">MLKFSREDEIWACLALSKTRSLGCKTWQKILEVFRSPAQALANSSHWAEMGLVSSSQAGIFNSGQWKSEAQREFERIQSGQEQVLIWSDSEYPEHLRHIAGPPVLLYYLGDISLAKSPSLAVVGSRNSSAYGREMTSKICRELSEKGITIVSGFAEGIDREAHRAALSAPGSTVAVLGTGIDLIYPAINQDLWTHIRDHGLILSEFPRGTRPDAHNFPYRNRIISGLSLGVLVMQAEIKSGSMLTAGYALDHNREVFALPGQVNLPGFSGCNQLIRQGAILVRTAQDILEALQLGLKNHLQQENDNEMSAPVPAEPALPGDLTSEEKAVAGELINRERTHIDDLSQCLDLSPSSISRILVNLEIRGMVRREPGMYYKFVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRC7</accession>
    <name>D6SRC7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870601.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0569"/>
    <dbReference type="EnsemblBacteria" id="EFI33243">
        <property type="protein sequence ID" value="EFI33243"/>
        <property type="gene ID" value="Dthio_PD0569"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1535774at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="338" mass="37003" checksum="6AAB57A8D1EF44B9" modified="2010-08-10" version="1">MHFKSIGLARTNYLDPEDCPRQGRGDMPACTIELDPEYAPGLHRLRQGQEVVVLTWMHLARRDVYRLRPRNDPARPLHGVFCTRSPHRPNPIGLHQVKILKIHDCRIVVHPLEVVDKTPVVDIKPVLGERSPESGVEQYFSPEDIQSLVLAGRRGWERGLFSGCNGNLSLRRGGLVLITRSGCPKSCLETVDLSVMDLESGSTLAGGPASIESGMHLQIYKRQEKAGAVAHTHPLSLLALSRAGEGVLFKKKDLFEARAALKGLGRVEAMDPGSRDLARAVGDKAREYDSIFMDGHGLTCLAGDIAGAMNRSEELESLAGLEVTTRLLESQALSLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRJ8</accession>
    <name>D6SRJ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trimethylamine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trimethylamine methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870672.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0641"/>
    <dbReference type="EnsemblBacteria" id="EFI33314">
        <property type="protein sequence ID" value="EFI33314"/>
        <property type="gene ID" value="Dthio_PD0641"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1052788at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015948">
        <property type="term" value="P:methanogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038601">
        <property type="entry name" value="MttB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010426">
        <property type="entry name" value="MTTB_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06253">
        <property type="entry name" value="MTTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="485" mass="54260" checksum="EE76317A7BBC170F" modified="2010-08-10" version="1">MPKINQTIQTTPKFRVLSENQIEMIYSAALDVIQRTGARFHHDEALELFKNSEAVVSDGNLVRVPISLVEKAIKSHPRKINLTGRTAKHRIKLEKDTVNFGTGSDLPFTYDRETGERRRTNYNDVVNAARIVDFLPNLDFFMSHGIVQDVPNPQTYDRHQFMAMLKGCTKPMVLTSVDGEGLEDLWKMASLFRGGEKEYRLEPMFVTYIEPISPLKNDNTAVEKLLFSAEKGIPCMYTPCPSSGATAPATMAGMLVQSLSETMMASVLTYLKNPGMPLVMGGVTTVLDMITTTYSYGAPELSLASAANTDISKWLGLPMFSTGGCTDSKVLDEQAAIESATSNYYAYLSGASLVHDVGYIDSGVNASLESLVMNDEIIGMIRQIGKGINTEDEYLALDLIDKIGPGGEYLTSEHTLTHYKDWFQPRLQDRSDYETWVREGKKTMNDRIKEETERILQEHQPEPIDDKLQKELEKIIDAAEQRHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRK0</accession>
    <name>D6SRK0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870674.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0643"/>
    <dbReference type="EnsemblBacteria" id="EFI33316">
        <property type="protein sequence ID" value="EFI33316"/>
        <property type="gene ID" value="Dthio_PD0643"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="327092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="207"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="681" mass="74286" checksum="BBCDE03E17D85B5F" modified="2010-08-10" version="1">MTQSRLSTRNPADGRDIPKSGRDYVVGIDTGGTYTDGVLMDYGTREVLASAKTLTTYDDLTRGIIDVLHKIDIDAPSRVKLVGISSTLATNFIAEGNTKPVGLILMGYDQDLIESYGLDSRFATGNYAYFQGGHNAQGEEQSPPDLEGIKNWLKDQQGRLEALAISSYFSPLNPEHEEQAMQAVREVTDIPVVLGHQLSTQLDSIKRATTASLNASLVAVMHEFIQAVKASLKDLGIKAPLMIVKGDGSLMPYTEAARKPVETILSGPAASSIGGRFLSGLDSALVVDVGGTTTDMALIENGNITVSGHGARVGLMETSVQAARIRTVCIGCDSRISINSAKEFQVGPNRVVPLSRLAAMYPEVLQELENLGRGRDCSKSQSDIEYWFQAREVDPDDPVLEHPAKKAVLDLVAQRPLTLHSLLKKMRVNHLVQLNVEDLLQKRIIGVSTLTPTDLLHVRGELDLDSQEASRAAFKYICGLYGLEAKEFNSRIMDHIVAEMTREAFIFLARQGQEDLPEDLDGTWSRWLFQEGLLQNDAYMGISLTSRFPLIGIGAPAEIFVSRVARKLNARFELPRCPGVANAVGAVAGSVIVDKEALVFLQESDSSRSYIVQFEGEKSSYAEMEEALAYAEKTVKRAARWSAEESGAEEPMVSARKNIEGTLHRVQARAVGNPSLSEQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRU2</accession>
    <name>D6SRU2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870763.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0740"/>
    <dbReference type="EnsemblBacteria" id="EFI33408">
        <property type="protein sequence ID" value="EFI33408"/>
        <property type="gene ID" value="Dthio_PD0740"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="181" mass="22403" checksum="50158F8929D50F5E" modified="2010-08-10" version="1">MSTEPFTQEQISFLKEHMSQWLAEQSLGKPPMVYEIELRERMVRVEEELRNQRELIQYIIEQMDKRFEQVDKRFQQVDKRFEQVDKRFEEMRQDMNARFEQVDKRFEEMRQDMHLRFEQMDRRFEDMRQDMNSRFEQVDKRFEQADQRFLALTKRMDRLLIWSFGTTVTVGGLIVAILKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRV6</accession>
    <name>D6SRV6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33422">
        <property type="protein sequence ID" value="EFI33422"/>
        <property type="gene ID" value="Dthio_PD0755"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="9446" checksum="03B29F28D8D5224F" modified="2010-08-10" version="1">MLDIDFGLKEWNELDPKEIVRKYRQFVYETGAVDAGKGKTIEKKIVEKARKKGYKISRVERFRYRCRYFTRLNTQHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS02</accession>
    <name>D6SS02_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0802"/>
    <dbReference type="EnsemblBacteria" id="EFI33468">
        <property type="protein sequence ID" value="EFI33468"/>
        <property type="gene ID" value="Dthio_PD0802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17865" checksum="0C8A41F17876E84F" modified="2010-08-10" version="1">MHKPYFPSVDGHPPPLRAVCSRWVRFEEVDPLGIVWHGRYPSYFEDARMALGEKYGIGYMTFYEHNVSVPIKRMHVDYHGPLGFSEEFTVEGIQHYCEAARINTEYIIRNKAGAVTTRGYTVQMMLDADRNILMTFPDFYSEFCRRWKRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS54</accession>
    <name>D6SS54_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">Dthio_PD0854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870870.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0854"/>
    <dbReference type="EnsemblBacteria" id="EFI33520">
        <property type="protein sequence ID" value="EFI33520"/>
        <property type="gene ID" value="Dthio_PD0854"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="130" mass="14607" checksum="A98C845CA3668893" modified="2010-08-10" version="1">MKRVMIDTNIYSLALKGDPEVADYLRKVDKIGISTISIGELLSGFKGGNREDKNREELDFFLDSPRVVVHAVDVETADFYASILDKLKSAGTPIPTNDMWIAASAFQHGYKLFSRDRHFEMVQGLILVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS79</accession>
    <name>D6SS79_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870895.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0879"/>
    <dbReference type="EnsemblBacteria" id="EFI33545">
        <property type="protein sequence ID" value="EFI33545"/>
        <property type="gene ID" value="Dthio_PD0879"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13548" checksum="21D89F0B317E9D2B" modified="2010-08-10" version="1">MSKKILVVDDELHIRMLYQEEFENSGYNVVTSDGSEPILSLLDQENPDLVVLDIKLGQDKSGLDLLQEIRSRDQSLPVILCTAYDSFQHDLKSIAADHYVVKSVDLTELMEKVKQILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS91</accession>
    <name>D6SS91_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0891</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870907.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0891"/>
    <dbReference type="EnsemblBacteria" id="EFI33557">
        <property type="protein sequence ID" value="EFI33557"/>
        <property type="gene ID" value="Dthio_PD0891"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042883">
        <property type="term" value="P:cysteine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014216">
        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02857">
        <property type="entry name" value="CydD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="558" mass="61230" checksum="B60E22E33EB136F2" modified="2010-08-10" version="1">MSQTQALKWLNSFRKTAGTALALSIGLNLCAGILLIVQAGALAWSVHQVVFEGLGLGRVMPALWLILALVLARAMLVWYGSSLAGQAAARTKEKIRRQLLEHLSRADPSGLTSHSTGQLVHLSTDGVEEVDGYFSGYLPQMALAAMLPPAILVFILPLDWISGLILLFTAPFIPFFMILIGRRAQKLNQQQWQKITRLTHRFLDAIQGLTTLKIFNAGKREARVVDEISKEYGKSTLSVLRVAFLSALILEFMATVSIAVVAVIIGFRLLWGEIDFMAGFFILILAPEFYLPLRNLGSRFHSRVSAIAAAENMMQLMSLPRRRDNTGTTIPSFSRTRIRFENVSFGYAQDQEAVHNLDFITPAPGLTCLTGPSGSGKTTVLRLVLGLVTPRQGQIYVNDANLSHLNNEAWLRHAAYLPQKPHLLGLSVLENIRLGNENASAQEVYLAAQKAGIHQEILALPHGYATVLGEDGQDLSGGQRQRVALARAFVRPCPLVLADEPGAGLDRKNRNIIHAALLEMAEERTVIICTHDQDVLPGADLVVQLKDMPPGQDMVQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSB3</accession>
    <name>D6SSB3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH ubiquinone oxidoreductase 20 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870929.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0914"/>
    <dbReference type="EnsemblBacteria" id="EFI33579">
        <property type="protein sequence ID" value="EFI33579"/>
        <property type="gene ID" value="Dthio_PD0914"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="986649at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="4">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="312" mass="34116" checksum="F7544495F20DE225" modified="2010-08-10" version="1">MTKVTVAEEWLNACAGCEIAILNVGDVLVDLLVNNLDFVHIPVILDKKYFGQTGEEEHLSIPEAVVGIVSGGVRNEEHKEVLLEMRKKCQILIALGTCATDGGIPAMINMYSDEELKKFTYKDSPTTDPADYPTEHIPPLLDQCYALDELVKVDLYLPGCPPHPDWIAGAVLALLEGKTEYRMPEKSVCDACPTIRESKKGLADIKRMLSAPEFDPEKPLDEMRCLLEQGFLCLGPVTGVGCGGKEGAPRCISARVPCRGCYGPVRKGAKPLVDYMGALASVGFDPNKMPDRRGYLARFSGAHGTLKRPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSB5</accession>
    <name>D6SSB5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fumarate reductase/succinate dehydrogenase flavoprotein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HdrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0916"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0711">Selenium</keyword>
    <keyword evidence="8" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="944"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113012" checksum="3A0E5685C4CDF46C" modified="2010-08-10" version="1">MSAEKVGAVMVVGGGIAGIQSALDLADAGYYVYLLEKSSGIGGAMAQLDKTFPTNDCAMUIISPKLVECGRHLNIELLTLAEVEGISGREGNFSVKVRQKPRIIDMDKCIACNLCAEKCPKKVPDEFNEGLDKRKSAYIKYGQTVPLKYAIEKETCIFFVKGGNKGEKGKGKCRACEKYCPTGAIDLDQDFQDEIKEINVGSVILTPGFKPFDPSAFDTYAYSQFKDVVTSMEYERLLSSNGPCMGHLTRPSDGSEPKKIAWLQCVGSRNINKCDNGYCSSVCCMYAIKQSMVTAEHTTGDTDQAIFYMDIRTHGKEFDKYFEQAKENGVRFVQSRIHTVYPGQDGCGVKVEYFNDQTGERVKEEFDLLVLSVGLENSKSSVDLAEVLGVELDKYKFADSSSFTPSATNVPGIYASGCYQGPKDIPQSVTDASCAAASASISLSSQRGSLTQERTFPPEKEVSGEEPRVGVFVCSCGINIAGTIDVNELVEYSKSLPNVVMVENNLFSCSQDTQVMLKDKIQEHNLNRVVVAACTPRTHEPLFRETMKDAGLNEYLFEMANIRNQNSWVHGKEPEKALDKAKDQVRMAVVKASMLQPLEHLSVNVNQSALVVGGGLSGMVSALGLADQGYETILLEKADKLGGNAWNLASTWRGEQIKPYLEELISRVENHSSIKVYKNAQLKTNKGAVGDFVSEIEVNGEKKAIKYGIAVVCTGGQEHKPQEYLYGQDERVFTHLEFDREMSEHAPALDKAKGAVFIQCVGSREPDRPYCSRVCCTHTMHSAIKLKKANPKMPVYVLYRDIRTYGAREDLYKEARELGVIFIQYELDNKPRVSKDGDDLVVMARDHILYRDVEIRPSYLVLASAVVPTEHKELVELYKCGLNSEGFLQEAHAKLRPVDMSVDGMFLAGLCHYPKPVDECIAQAQAAVSRASTILSRSVMPLDSIKSFVTENCDGCAICVDTCPYGAIGLTDYDVEGVQHKKIETNKALCKGCGICEATCPKQGVFVHGFTNEQLRAQVHAVLENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSH6</accession>
    <name>D6SSH6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0977"/>
    <dbReference type="EnsemblBacteria" id="EFI33642">
        <property type="protein sequence ID" value="EFI33642"/>
        <property type="gene ID" value="Dthio_PD0977"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="284"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="337"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="413"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="467"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="540"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="607"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="836"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="919" mass="103168" checksum="B978D98603F8D8B0" modified="2010-08-10" version="1">MHDKTQDAKDLQQENAELRARLEDTQETLRAIRSGEVDALVVSTDQGEQVFTLKGADHPFRVLMEDMSEGALTLSSDGIVLYANQRFAEMLKSHLNLVAGSDLVQWIQSGHRCRFYSLLQGQSGQRSSGEINLVDSQGALVPTQFSLTPLETQDIQGAFCAVVTDLSEHKRLQEIKAAEQTARARAQEAERYSETLESLVRDLNKARKGLKENQNFLESVLDTIQDGIVVLDKDMNIIKTNRVIQNLYSLDHSRQEKCYTAFHGRREPCDLCPTSRAMQTGNLEVEEIPIIQNGVETGTMEVFAYPMRDEQGNITGVVEYARDISKVKRNRQALKRSQALLSRTQEIADIGSWEMDLDKDVLTWSDQVYRMFGYAPQSFQPGYQSFLDAVHPEDRESVHKKYLESMLDVSQGFEFEHRIVRADSQEVRYVREQGLHELDDAGRVVLSYGAIQDIAENKLAADKLREREEKYRALVDQSVEMIYLHDMEGRFIEVNAAAVSNTGYTREELLSMNVFDLHTDQLSQEEVKNYWQSMLPGQSMTVETEHHKKDGSVIPVEVKIGKIYYSNQEHIMALVQDITERKQVHQELIARRSAEEANRAKSRFLANMSHEIRTPMNAVLGFARMLENDPALPAKQAAQAGTIVRSGDHLLQLLNSILDMSRIEAGQSGLHPEDFHLPGLIDKLMTMFELSAQDKGLELVLEKDPHLPPDLHADQGKLLQILTNLLSNAIKFTSTGEVKLTISSKPPGPADTACEEQDLGLVFQVQDSGPGITAQDQAQLFEPFFQTQNKMHPGGTGLGLTISREYAVLMGGNLTVSSQEGRGSCFRLEIPVKRARTQTTPRQPASAMQKPQADRGPPGFDHSVTQEICEAVSQGDVVKLMQTLDEAAGQDQESAVKLKDMARNFEYDRIMHWLNHSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSR6</accession>
    <name>D6SSR6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871081.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1071"/>
    <dbReference type="EnsemblBacteria" id="EFI33732">
        <property type="protein sequence ID" value="EFI33732"/>
        <property type="gene ID" value="Dthio_PD1071"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="753726at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="202"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="411" mass="46861" checksum="44C7D86E37165A15" modified="2010-08-10" version="1">MQEEKPAPWNIEPLFVGRQPVFNAKKRLQGYELFYRSDEESAGAVFSNPEDATLSVIQASYVSPFLNMKGEKFIMVNFSYEAIVHNAPYALPPQNTIVKITGHTPGGHELEQALAELKKDGYRIAVDGKPGEISRWMDLADIFILDAGVAGEGLQEIDTSDVAVMAKRIEDVETFQKLQEKNISYFQGYFFKRPETLKGANLSTHQIMRLKIFQVLQQEEPDLDELASLLEKEVSLTYRLLRYVNSASFGMLTPIKTIRRALTYVGFKNLRTFLQLCLLRDVTPQSKPSELPFAAALRGRFLELVVFPTKDEWPQPDALFMLGLLSLLDAVFDMPMENVVQDLPIDEDMKKALCREESLYLPWLYLAIAFEKGDWENVDALISQLGLHPRKVAMSYSWAMGWARDFFEYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST23</accession>
    <name>D6ST23_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871188.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1178"/>
    <dbReference type="EnsemblBacteria" id="EFI33839">
        <property type="protein sequence ID" value="EFI33839"/>
        <property type="gene ID" value="Dthio_PD1178"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1929765at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088186" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="14865" checksum="0B2CCBD5C5AED25C" modified="2010-08-10" version="1">MYQRLQKLALPGLILALALFLAAGCVKDEPRHVAGYEPGEPIPTVEVETDVPNPFHTFVGIDFVKPIVADNVLREEPRDDVMLIDARPKRPRFDRGHIPTAVSLPDGEFEEKAEDVLPEDKSTLLIFYCMNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST39</accession>
    <name>D6ST39_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4168 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1194"/>
    <dbReference type="EnsemblBacteria" id="EFI33855">
        <property type="protein sequence ID" value="EFI33855"/>
        <property type="gene ID" value="Dthio_PD1194"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031CUR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025433">
        <property type="entry name" value="DUF4168"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13767">
        <property type="entry name" value="DUF4168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088069" description="DUF4168 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4168" evidence="2">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="141" mass="15915" checksum="F46B6C52AF23EFF5" modified="2010-08-10" version="1">MFSTKSSIVLSLAAAVMLILGFGLNVQAQQEYQQEGQQQQYQQEMMQQQQAPDIDVSDAELDQVADAYQAVTDVREKFQQELGEVSDPERAQELQQQAGEEMVEAVEAQGLDVQTYNQVMEAAQVDEELRNQLLERLEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST46</accession>
    <name>D6ST46_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871211.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33862">
        <property type="protein sequence ID" value="EFI33862"/>
        <property type="gene ID" value="Dthio_PD1201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="9484" checksum="96E06C8FE062FBB7" modified="2010-08-10" version="1">MASNKTENGDARVVDYKQMNIPDDLSDSERQMYEDNQTVQLKDKNTGETVEVSRTEESPELGKLLMVCGIIGAVLVAGFLIFSLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6STC3</accession>
    <name>D6STC3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Addiction module toxin, RelE/StbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1278"/>
    <dbReference type="EnsemblBacteria" id="EFI33939">
        <property type="protein sequence ID" value="EFI33939"/>
        <property type="gene ID" value="Dthio_PD1278"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004386">
        <property type="entry name" value="Toxin_YafQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40588">
        <property type="entry name" value="PTHR40588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15738">
        <property type="entry name" value="YafQ_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006156">
        <property type="entry name" value="YafQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="11290" checksum="6048DC9D55CCC787" modified="2010-08-10" version="1">MPAPPQRLRPHVKRMKKRGNNLEKLKIIISSLLNQEPLDDIHRDHKLIGNWKGRRECHIESDWLLIYLVEPDRVVFERTGTHSDLFQKLREEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6STI5</accession>
    <name>D6STI5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplS</name>
        <name evidence="7" type="ORF">Dthio_PD1340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871350.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1340"/>
    <dbReference type="EnsemblBacteria" id="EFI34001">
        <property type="protein sequence ID" value="EFI34001"/>
        <property type="gene ID" value="Dthio_PD1340"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13705" checksum="DC5D780F77EB2473" modified="2010-08-10" version="1">MNIMQQIQQEQMRTDIPGFKAGDTVKVHVRIIEGEKERVQVFQGTVLRVKRGTTNSTFLVRKISDGVGVERVFPLNSPFIEKVEVVTRGKVRQGRIYFLRKLRGKAARIKARTDWHKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D6STL3</accession>
    <name>D6STL3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease R</fullName>
            <shortName evidence="6">RNase R</shortName>
            <ecNumber evidence="6">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnr</name>
        <name evidence="8" type="ORF">Dthio_PD1368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871378.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1368"/>
    <dbReference type="EnsemblBacteria" id="EFI34029">
        <property type="protein sequence ID" value="EFI34029"/>
        <property type="gene ID" value="Dthio_PD1368"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="619"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="702" mass="79270" checksum="605031D95A0A5821" modified="2010-08-10" version="1">MSKKLDQKKVLKHFKAMNKPLSIREIRDGLGVDKKEVSRLKDILRNLQKEGRIFKARKTYCLVDELPVVKAVLEVQRSGVGFAVPFDQRRRDIFIHPKNFGEAWHGDTVLVSVLPGGRGKNQEGRVVRIVERGIKQLPAKVIKKMKAGMYLARPADPKLDFSFILEDEGGELGPGVMVLVEPGEQMESRLWSADIQNVLGPEDDLAVQEQVVKENHQVPVKFPKGVLKEAASLPSEPAPEDIQKRKDLTDLPFVTIDGAQAKDFDDAVLVEKKGDGYVLYVAIADVSHYVQPGSRMDVEALDRGNSYYFPLSVEPMFPENLSNGLCSLNPGVPRLVMTAQMHFSSQGVREKASFYPAVIKSHHRLTYSQVNSALYLEDKKVREEIAPVLSGLETADELARKLLARREKRGSIEFDLPEPEVLQNLREGTLEIIAKSRNFAHQIIEECMLAANEAVAEFLEEKEALFLYRIHPPADRDKLDALFKLLATTELGPRLPKEREPKSLQTLLEIAKDSDLDFLVNRLVLRSMMQAKYSPVNEGHFGLASRCYCHFTSPIRRYADLVVHRALKRELGMDVQFKARMKSLKKTGESLSSLERKAVDAEREILKRATIISLKDKTGQSFSGIVASITDFGFWVELTDIMAEGMVRLSSLSDDYYVFRQEKQDLLGRRTGKRFYLGQKVQVVLQSVSLERLEVDLVLDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6STS7</accession>
    <name>D6STS7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871442.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1433"/>
    <dbReference type="EnsemblBacteria" id="EFI34093">
        <property type="protein sequence ID" value="EFI34093"/>
        <property type="gene ID" value="Dthio_PD1433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="154" mass="17474" checksum="41AF4E3EF1DDA191" modified="2010-08-10" version="1">MRQVNLEGVTNAPAEHEYVPGYVRGDGKWIDTRYTLHLTPENGNGSNGGNGNGNGNGRPRKIRINFWAGEALKAKRAFMDDPHTAEIKIVGGELAEYDCRYTGRTRFSVNINIREQVKIIKREPWVDDGFGFEGVLNKLQRQHEDQRDFGEPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6STU2</accession>
    <name>D6STU2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871457.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1448"/>
    <dbReference type="EnsemblBacteria" id="EFI34108">
        <property type="protein sequence ID" value="EFI34108"/>
        <property type="gene ID" value="Dthio_PD1448"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1802284at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="362" mass="40238" checksum="36257E7B8199AA33" modified="2010-08-10" version="1">MFKKAERRQSKLRFGIVGPSGSGKTYSALLIAQGLGGSVALLDTERGSGSLYADLCEYDVAELTPPFSPERYTQAIKEAERTGYEVLIIDSLSHAWSGEGGILEFVDRASQAQKNNFAAWREASPKHNALVDSILGANLHVIITMRSKTAWDVVKDERTGKTRPVKIGLAPVQRDGLEYEFTCVLELSVDGHIATASKDRTGLFDGQYFLPSKDTGQILKEWLQGGRPDNGNKENKPAEPKIDSEVEAEPVADPAPASRKKSQDVFTKKKQRQEDRPPQPLTPEDNGVTVASLVNTMRELGLSDKLDLYEAYLLGKYGNDLRKLTKDQVNEQYHNLCRCKRDQELFQRFVTYLDGLSKKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6STY5</accession>
    <name>D6STY5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1493"/>
    <dbReference type="EnsemblBacteria" id="EFI34151">
        <property type="protein sequence ID" value="EFI34151"/>
        <property type="gene ID" value="Dthio_PD1493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="88" mass="9345" checksum="B113B3084BDA0962" modified="2010-08-10" version="1">MHSLAFLPQALQERAVTIQGVPVITTERSLKAYSPAVSGKAARSPRETDFCLRAAGFTGVCNEVARAKKIFSGTGSLQASHRCSAHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6STZ6</accession>
    <name>D6STZ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871509.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1505"/>
    <dbReference type="EnsemblBacteria" id="EFI34162">
        <property type="protein sequence ID" value="EFI34162"/>
        <property type="gene ID" value="Dthio_PD1505"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="6">
        <location>
            <begin position="717"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="713"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="803" mass="88385" checksum="52F1470D7A6CF7E2" modified="2010-08-10" version="1">MSLTINHNPMAMNAQRNLESHYGDLATSTRRLSSGLRVDTAADDAAGLAVRELMRADIAAMNQGVRNANDGISAIQTADGSLEVIDNKLIRMKELAEQAATGTYTQEQRDVIDGEFQQMKAEINRIANQTEFNQQKLINGNLSGDNSLKVHFGPRNNDGEDFYYVDMGDATARGLNIENTYLQTNMEDRLADNKNSLTQLNDQINREEPDNPDQFMDNLDSIRHSLEGMRDDLLTAYEDEKVTEEFQQLQDGIENAISQLDQAIGEYENSDDIDWQSIDENISSAVRFLEGKERVVEGLGDALAGEVSGGITYHATVDGQVFEYEAASGDSASNVLEGLAYEINQSDDYDARVENGDLVVYGAGQVGVYELEEGSGDTALEISHDGEDTNLTIEGPEPQEGMLYRLEIESGADGAGLDENLNIDYVAREGDTLEDVMRALTQQINDETDLEASYSSSEDGQITIEGENVSNAIDFYHSQSLVYEERTIENLTNEINPDASGNETFHININGESFTYTTESGDTDEDVIEGLVDAINESETYTASYDSDDDEMTIQGAATSDIAVYELSSDEVTYTVDSGESGENTVEITDGPLWEGAVYALDVGSGSVDNLERYEYTVQDGDDYEDIMRALAEQISVDDHIDDAYFDEDEGVIVLQDSNIESGETWAELQASDRLDGDIEINNPSATLVDPNLQEDAEEFDNHINEVKPTLYAQNALEEIDAAIEIKDRIRADLGAYQNRLDNTVSNLQIQAENLQAAESRISDVDVAHEMTQFTRNQVLSQGATAMLAQANTLPQMAMQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU23</accession>
    <name>D6SU23_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871806.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0429"/>
    <dbReference type="EnsemblBacteria" id="EFI33114">
        <property type="protein sequence ID" value="EFI33114"/>
        <property type="gene ID" value="Dthio_PD0429"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="200" mass="22917" checksum="ECF07E5C7DA8ACDB" modified="2010-08-10" version="1">MSSNNFYQNQAQDYCEQTFGIDPSSFLLPLTRYLQPGASILDIGCGTGRDMLWLHNKGFYCTGLDCAPALAELARQHTGLPVIEADFESFDFSGLKEDALLMVGALVHVPHEKFKTVFKHMLQALKVQGTILITLKKGQGTEIRSDGREFYLWQKDDLFQTFSDFSLVCLEYFEQESKIRSSDIWMSFVLQRRNPHRQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU27</accession>
    <name>D6SU27_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871810.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0433"/>
    <dbReference type="EnsemblBacteria" id="EFI33118">
        <property type="protein sequence ID" value="EFI33118"/>
        <property type="gene ID" value="Dthio_PD0433"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1718602at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="221" mass="25167" checksum="F39CE3A2020C543B" modified="2010-08-10" version="1">MCGRFALYEPSDIIQDHFGLDDASELVPNYNIAPGTGILGIAYYENSLVPMFLKWGLIPHWSKAKQTQYKMINARVETVWDKSSFRSAIRYRRCLIPASGFYEWKKTDSGKQPYFISVSGTNIFAMAGIWETWEDKSSGEVIDSCAIVTTEAQGAVKEIHDRMPVTIDRSGYKNWLDPMVQTRDQLKIYQLDHSLITVWPVSPKVNNPRNNGPELIQQVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU31</accession>
    <name>D6SU31_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33122">
        <property type="protein sequence ID" value="EFI33122"/>
        <property type="gene ID" value="Dthio_PD0437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="12857" checksum="79E526A11144A6EA" modified="2010-08-10" version="1">MNSVQFEMAGELFSEMNDHQAAVTAYGLALQKYRTEQGIKLILMENVMRYLSLCAGLSCCILFAFFNVSNAFADNSSVEVTVSGSGTSQGAALTEAYVEAVRQTLSRVVDKDTAIEPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUC6</accession>
    <name>D6SUC6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871599.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0220"/>
    <dbReference type="EnsemblBacteria" id="EFI32906">
        <property type="protein sequence ID" value="EFI32906"/>
        <property type="gene ID" value="Dthio_PD0220"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="191" mass="20962" checksum="4B4E7E8C5B01F699" modified="2010-08-10" version="1">MHVVAFNGSARKDGNTAGLVRMVLNTLEQENITTEHIQLGGSHIQGCIACSKCFKNQDRHCSVKDDMLNQYIDKMLDADGIILGSPTYFANVSTNIKSLIDRAGLVSKANGDMLARKVGAAVVAVRRSGAIHVFNSINHFFLINQMIIPGSSYWNNGLGLHPGEVEKDDEGRQTMYNLGKNMAWLLGRIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUK5</accession>
    <name>D6SUK5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methicillin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871678.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0299"/>
    <dbReference type="EnsemblBacteria" id="EFI32985">
        <property type="protein sequence ID" value="EFI32985"/>
        <property type="gene ID" value="Dthio_PD0299"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="355" mass="40399" checksum="95717DB70A768E8C" modified="2010-08-10" version="1">MDLQLKPKEPQELLPTDILFQTLYWARVKSRLGCRVMAFDIQPDLFSPAGDVLVLLQRYGPEMKSALVPQGPEFLPPKEEYGPFLESLSYELMHHLGPDTAFIRYDLPWESQYAREMQQGHWYGFPEPRLREMRMNMGTESWNLRKSSMDMTVASTLVVDLDPAEKDILGRMKSKTRYNIGLAGRRGVEVQTGSMEHLPAFYDLYLQTAARNGFATCAYEHFSAIFNAHIFDPCNSEVLFLLAACDQELLAGGIVAISGQTAHFLYGASSNTRRHLMGSYAVHWEAMRQSRLRGCLRYDMGAVSPGADPDHPFYGLYRFKSGFGGRLEMRSGSWDFPIDEEKYQAFINTDNLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUN1</accession>
    <name>D6SUN1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">Dthio_PD0325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871704.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0325"/>
    <dbReference type="EnsemblBacteria" id="EFI33011">
        <property type="protein sequence ID" value="EFI33011"/>
        <property type="gene ID" value="Dthio_PD0325"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="10868" checksum="EF4E7012B954CAA8" modified="2010-08-10" version="1">MHSTQVLIRPMVSEKSNDLKEVQNKVVFAVHPGANKFQVKNAVESIFNVKVDKVNIIRRQPLQRKRFGRVSGKIPGYKKAFITLAAGDKIEFFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUS7</accession>
    <name>D6SUS7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871750.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0371"/>
    <dbReference type="EnsemblBacteria" id="EFI33057">
        <property type="protein sequence ID" value="EFI33057"/>
        <property type="gene ID" value="Dthio_PD0371"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="490746at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="16"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="483" mass="52582" checksum="98393158E0A7B5BA" modified="2010-08-10" version="1">MSLPLLKNYINGEWEQSGTTETGTVWNPATGEKLAQVPYSTASEVDRAVQAAREAFQEWRTVPPIKRARYMFALKEVFEENFEDISKTLVREMGKTLDESRGEVRRMIENVEHSTGVTSLAMGSTLEDIARGIDCSSERQPVGVFGCIPPFNFPAMVPWWFMPYALVTGNTFVLKPSEQVPMTQGLIFELMEEIDLPEGVVNMVNGSKEVVNAMLDHPDIQGISFVGSTPTARYIYKRCGETGKRVQSLGGAKNVITVMPDTNIDKAMPSIITSFFGCAGQRCLSGAVLAPVGDIADEFLEKFVEQARNLKVGDGLDSGTQMGPLVSAAHKERVLGYIEKGISEGAELVLDGRNPAVENPEGFYVGPTIFDNVSKDMTIAREEIFGPVVSVLRAGSLQETIDYANSTGLANAACIYTSSGGAAREFKYKVKPSMVGVNVGIAAPMSFFPFGGAGDSMFGTHKGQGQDVFQFFTDAKVVISRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUS8</accession>
    <name>D6SUS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871751.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0372"/>
    <dbReference type="EnsemblBacteria" id="EFI33058">
        <property type="protein sequence ID" value="EFI33058"/>
        <property type="gene ID" value="Dthio_PD0372"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="9"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="41018" checksum="77DC5CC30F083375" modified="2010-08-10" version="1">MKNCTFRSPPTIHCGSGFSAKAGPEALRSGATRVLLVTDSTLKEMNVIAPALDSLNEAGLQVVVFDEVDDEPTLEHVEKGLELLRRHGCDFLVACGGGSPIDAAKAIAIEAVNEGRILDYAGIDKIPGPGLPVMAIPTTAGSGSEATMVTIITDARTDVKMLLISPWLMPRVAVIDPLLTLKCPRHITASTGLDALTHAIEAYVSVKSQPMSDMLALSAVRLINTYLPRAWANPDDLEARSQTQLGSLQAGMAFTNSSVALVHGMSRPIGANFHIAHGVSNAALLGVITDFSLLGAPQRYAAIAEAMDQPVAGLPVHQAARLCADRTKELIEQLKIPSLSQLGVTREKLDPLVHKMTDDALASGSPGNNPRKATRDEIVELYYQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUV5</accession>
    <name>D6SUV5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33085">
        <property type="protein sequence ID" value="EFI33085"/>
        <property type="gene ID" value="Dthio_PD0400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8488" checksum="127DE267ADBE9779" modified="2010-08-10" version="1">MCGEAACSSHPWRTATDLLSDMSENNEKIPEPIVSDDEEAGSVEVTPNITAELNNRGELIGIEILGASTFIRLTPETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV09</accession>
    <name>D6SV09_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0056"/>
    <dbReference type="EnsemblBacteria" id="EFI32765">
        <property type="protein sequence ID" value="EFI32765"/>
        <property type="gene ID" value="Dthio_PD0056"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="351" mass="41287" checksum="D1094903BCDAA5DB" modified="2010-08-10" version="1">MSTKRNQAPHEGLFLKIFQNLDNARHFLKKHMSEELQKRFDLDTLRLEPTTYVDEKLKKHYSDLVFSVRLIGYKNQFAKIYLLFEHKSSPDPLTGVQVLKYMALQWLDLQEQHMLVDGKLPPIIPIVIYQGQEDDRNMCSSFHDLVEMPSESFKVYIPDFSFAFFNVRGMDEAKVREKILLKFYVEIIKYQNDPSVKEIPPRLVRGLIESLGYRTALEYIEIFFRYLVKSTGYLSQEDYKKALELLPEGGESIMETLADQWMEQGAQKERHRAEEWIKQEKDKWERQAELKNAKETLIDVAGDCHGPLPKSLQDKIKSIDSIDNLRTLTRKVYKTQSLEEFTELVNRATQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV54</accession>
    <name>D6SV54_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0112"/>
    <dbReference type="EnsemblBacteria" id="EFI32810">
        <property type="protein sequence ID" value="EFI32810"/>
        <property type="gene ID" value="Dthio_PD0112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10817" checksum="518E20FDB066A28B" modified="2010-08-10" version="1">MSPKPVTIIPIARKKLSQRGVDESMVFETIQEPDQLVEGTKGRAVAQRKYFFDDTIYLLRVVYEEEDNQLTVITGYFTSQVSRYWEEQQHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJV3</accession>
    <name>D6SJV3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IstB domain protein ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0065</name>
        <name evidence="3" type="ORF">Dthio_PD2978</name>
        <name evidence="4" type="ORF">Dthio_PD3612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868684.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0065"/>
    <dbReference type="EnsemblBacteria" id="EFI32772">
        <property type="protein sequence ID" value="EFI32772"/>
        <property type="gene ID" value="Dthio_PD0065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35552">
        <property type="protein sequence ID" value="EFI35552"/>
        <property type="gene ID" value="Dthio_PD2978"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36156">
        <property type="protein sequence ID" value="EFI36156"/>
        <property type="gene ID" value="Dthio_PD3612"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="104"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="253" mass="29037" checksum="ED91B6A94E4BC725" modified="2010-08-10" version="1">MTNKHQSEVHRLEENLQLLKLTCIKEQYRPAADKAARQNWDHLGYLARLVQAEADARHDRSIQRRIRMARFPGIKTMENFDWTWPTKINRPAIQNLFRLGFMKDKANIIILGGVGLGKSHIATALGYSACLEKYSVLFATTIDVINTLSAAQAAHKLKTELKKYVSPELLILDELGYLPIDKQGADLLFQVISQRYEQKSTILTTNRAFKKWPEVFNNDSTLTSAMLDRLLHHAETVLIEGKSYRMKDQVQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJX3</accession>
    <name>D6SJX3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869298.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3632"/>
    <dbReference type="EnsemblBacteria" id="EFI36176">
        <property type="protein sequence ID" value="EFI36176"/>
        <property type="gene ID" value="Dthio_PD3632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="143" mass="16664" checksum="E53AF72A1B518C32" modified="2010-08-10" version="1">MQEINIEGWTTAPVEHEFVPGRIREDGKPVEHRYTLHLLIPKNGSGQYIKARVNFWAAQALKAKQLLMDEPHKAHLKIINGTVSDYTCRYTGKKRYSVNVNDREQVKLLERKPWVDDGLGFEAVLNKLQRQHEDQRDFCEPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJY1</accession>
    <name>D6SJY1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869306.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3640"/>
    <dbReference type="EnsemblBacteria" id="EFI36184">
        <property type="protein sequence ID" value="EFI36184"/>
        <property type="gene ID" value="Dthio_PD3640"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2069538at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="191" mass="22730" checksum="5BB9545DAAA96321" modified="2010-08-10" version="1">MNKQNLKPTKQMVKNWKAARIWFKQYFSLLNGIGWTKKLFFRAGLDRSSFREWSPAWMHCWSQPGLKVKPDRDGRIFFTWPTEKGCATTCWWPGKDSELTKRMRNSKGKPQYRSKPKSNVPPGYINITKLYERWPGDLIEEFAAIPDMTKPNPINPQWRPMKLYSLKRIEEIETSSDFQKRLRSSIFARQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJZ6</accession>
    <name>D6SJZ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FlgO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3655"/>
    <dbReference type="EnsemblBacteria" id="EFI36199">
        <property type="protein sequence ID" value="EFI36199"/>
        <property type="gene ID" value="Dthio_PD3655"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1839604at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041215">
        <property type="entry name" value="FlgO_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17680">
        <property type="entry name" value="FlgO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088085" description="FlgO domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="FlgO" evidence="2">
        <location>
            <begin position="56"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="195" mass="22151" checksum="848C87321BC05148" modified="2010-08-10" version="1">MPNTFDKKTCLCILVLLTLLYALSACDTSAKLERRYMDEQIKAELYEENLITINEEAADELLGSCNVPIDQNETVIVTSIVNIDDMHRSSTLGRMSSEMIANRLAQHGYSVREIKMGRNIFVSEAEGEFILSRELHEIGEKHDVQGFIVGTYAKGETRQFANTEVFVSLRYVDTGNIIRCSHNYIVSDTDLNMWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJZ8</accession>
    <name>D6SJZ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869323.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3657"/>
    <dbReference type="EnsemblBacteria" id="EFI36201">
        <property type="protein sequence ID" value="EFI36201"/>
        <property type="gene ID" value="Dthio_PD3657"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ZEZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016873at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="8439" checksum="1F6D896CBBC99AE0" modified="2010-08-10" version="1">MNQRKKTKYVHEGRYVAEVEVALLEDDTGWSPYLSIEDANKLDDVREALRQRDLQSAAKYGRIYELRPVVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK45</accession>
    <name>D6SK45_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1739</name>
        <name evidence="3" type="ORF">Dthio_PD3705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869370.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1739"/>
    <dbReference type="EnsemblBacteria" id="EFI34386">
        <property type="protein sequence ID" value="EFI34386"/>
        <property type="gene ID" value="Dthio_PD1739"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36248">
        <property type="protein sequence ID" value="EFI36248"/>
        <property type="gene ID" value="Dthio_PD3705"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7QT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1217533at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025639">
        <property type="entry name" value="DUF4338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14236">
        <property type="entry name" value="DUF4338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4338" evidence="1">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="292" mass="34137" checksum="A45B55BB85A25475" modified="2010-08-10" version="1">MQTILRYRGRDITEEDVRFIRQLIFEHPGDSRWALSKKLCTAWNWVQQNGQLKDMVCRGLMLALHRQGHIILPPAQKVTATGYNRKEPVSVQVDQTPLTSSLKDITPLEFRQVRKTPFESLFSSLLKEHHYLGYTQPVGEHLKYLVFANKQPIACLSWSSAPRHIGVRDNFIGWTQKDREKNLFLIAYNSRFLILPWIQVSCLASHILAQMTKILQRDWESIYKHPIYYLETFVDQERFKGTCYFAANWLYLGQTTGRGKNDHTGKANRSLKAVLGYPLTRDFRKRLRGLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK58</accession>
    <name>D6SK58_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase associated with various cellular activities AAA_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869380.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3724"/>
    <dbReference type="EnsemblBacteria" id="EFI36261">
        <property type="protein sequence ID" value="EFI36261"/>
        <property type="gene ID" value="Dthio_PD3724"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="36"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="302" mass="33469" checksum="162B7681D40387B5" modified="2010-08-10" version="1">MSRQHTDIIQSILDTINQGLLDKPFEIRLALASFLAGGHLLIQDIPGVGKTTLALSMARTLGLDFARIQMTSDMLPGDVLGVSMFDPRTNEFCFHPGPIFHSIVLADEINRSSPRTQSALLEAMAEKQVSADGRTYPLPEAFLVIATQNPLEEHGVNPLPNSQMDRFMMSITLGYPGPGSEKDMLTKGATVPDFEAVVSQEELLSLRQSCKDVFLSDEIARMILELTHATRDHAEVKTGLSPRGMLALKSSAQAWAMLEQRDYIIPQDLFNTAYSVMIHRLSLDPGKDRDLLVRKIIHETWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKA5</accession>
    <name>D6SKA5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869427.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3772"/>
    <dbReference type="EnsemblBacteria" id="EFI36308">
        <property type="protein sequence ID" value="EFI36308"/>
        <property type="gene ID" value="Dthio_PD3772"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="291634at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="123"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="431"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="955" mass="109154" checksum="81326CD1CD535DCC" modified="2010-08-10" version="1">MSQKSASTLAPGSRVLVRDAEWLVRRVDRASTGGQALTCVGLSELVRDREATFLTDLEALHSPVKSLDPARTRLVADSSNQYQDSLLYLESLLRQTPPTDSRLYTGHQAAMDFVPYQLDPALQALEKPRQRILIADSVGLGKTLEAGVLLSELIRRGRGKRILVVTMKSMLTQFQKELWTRFTIPLTRLDSIGLQRVRSRIPTNHNPFYYFDKSIISMDTLKQDNEFRVHLEKATWDVIVIDEAHNVAERGHGRTQRARLARLLSRQSDSLIMLSATPHDGRARSFASLMNMLDPTAIANQDDYGPDDIKGLFIRRFKKDIQHQVKGSFQERRISTCHIPATEQEERAFAGLAGLNLHSLNNKRTGGQLFQTTLEKALFSSPAACLETIDARLRQLQREPQADYVGDVQSLKELRSAVAEITSESFSRFQKLVDLLSSPSSELHWTGKDPLDRLVIFTERIATLEFLYRHLPPALGLKDRHVERLHGGLSDIEQQRVVEDFGRDESPLRLLIASDVASEGINLHYLCHRLIHFDIPWSLMVFQQRNGRIDRYGQERTPLISYLAIQSREPKIHGDMRILELLISKDEEAIKNIGDPSALMGVYDVEAEEARTAGALEQGLSPDDFAARDLSAPQDGPLDLLAFLEEGQEKSSDTSARQRLGQMPALFADDFEYVRLGLNRLDQDNDLSPDIDESLRVLDMNVPGDLLHRFAFLPREIQPRNGRLKFTDDKDTMQEEIRRCRKDEQAWPELHYLWPLHPVLQWLNDRVQTSFGRNEAPVLTLPSLKPEEIIYILTGIIPNRKGQPLIQNWFGVTVSGRAFKGMEPLEKILERTGLGSSTFSNPGNMKVSRQAEEMLPDVVQKAMKWMNEVRREFENRVNPQLNAHLEKLEQLKGRHRREIQLYFDEKYMPENVKSRRRDERMREVENLFAEYMEWIEDTMTTEEHSSIKVAAVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKA7</accession>
    <name>D6SKA7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869429.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3774"/>
    <dbReference type="EnsemblBacteria" id="EFI36310">
        <property type="protein sequence ID" value="EFI36310"/>
        <property type="gene ID" value="Dthio_PD3774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="141" mass="16243" checksum="C608630659BA2C2B" modified="2010-08-10" version="1">MNLNQIVIDTNVIVSSLKSRRGASFRLISLIGSGRFEINLSVPVIMEYEDVLTRNQDQLVFSRADIENFLDYLCSQARHHDIYFLWRPVLKDPGDDMILELAVTSNSDCIVTFNKQDFAQASKFSIYTATPKEYLKSRRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKI9</accession>
    <name>D6SKI9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35200">
        <property type="protein sequence ID" value="EFI35200"/>
        <property type="gene ID" value="Dthio_PD2608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="9008" checksum="5D88122234042D5E" modified="2010-08-10" version="1">MLVLKFIRFYPFDKIKANKILGKALNSACSQPFHRINPRHPTNERKFTLIFGAEQMLNLVKDFLHKVLPADNPGICSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKL8</accession>
    <name>D6SKL8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868363.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2638"/>
    <dbReference type="EnsemblBacteria" id="EFI35229">
        <property type="protein sequence ID" value="EFI35229"/>
        <property type="gene ID" value="Dthio_PD2638"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335E3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1818581at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="200" mass="23655" checksum="D3605956152434EF" modified="2010-08-10" version="1">MDQDFEQRFTAIFQREEQFAHTLATSVIQKPKLSVWMFLVPILFIYHANHIKRYKNNLANFQQGFTRTKLHALNLAREELVRGEKKEEREMDLFADYDVDGPNVQEVRNRQMEEIRLLIKHYRSLLRSSGRDYPELVRSAYKTKNEYKKFLNKLNQAEKEVNKAALHAFHDSDDSRKVVSEMEKQASILRNQEAGSIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKR2</accession>
    <name>D6SKR2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868405.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2685"/>
    <dbReference type="EnsemblBacteria" id="EFI35273">
        <property type="protein sequence ID" value="EFI35273"/>
        <property type="gene ID" value="Dthio_PD2685"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="307" mass="35666" checksum="507F9566C4D98B66" modified="2010-08-10" version="1">MDHFEPGITGNVQRIFRARYKLDEPGLTSHITQRAAGKDPLFLDDRDYLTMLGLLKESSEKFNISYYALCLMQNHLHILIKPYEKNLVQAMRSIFSRYAAKFNHRYERRGHLFGGPYRQSVCLDNSYLLSASLYIHLNPVRAGLTDNPNQYRWSSGSLYCLETPRESFVDPKPVLQLVHDDQNAARREYYKILHKAQGAEPDNALEHKGAIEKFCVRLAEIFPALFKRLNKKSSAYENIPPSMLELTELESRLQNMTDSRSRSTENRMARKYIIEQLLARGFKKTEIAERMGISRRSVYYLLNSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKS3</accession>
    <name>D6SKS3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
            <shortName evidence="3">T2SS protein E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Type II traffic warden ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868416.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2698"/>
    <dbReference type="EnsemblBacteria" id="EFI35284">
        <property type="protein sequence ID" value="EFI35284"/>
        <property type="gene ID" value="Dthio_PD2698"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013369">
        <property type="entry name" value="T2SS_GspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02533">
        <property type="entry name" value="type_II_gspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T2SP_E" evidence="4">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="563" mass="63024" checksum="A67D107F0267BB76" modified="2010-08-10" version="1">MLSLVELMMDKGLISRKDYEKLSSAGMQDEPFHRLALRTGLIAEDDYLDLLEEAYGYQVVHSLPEGFNPEQFGHVSVQFMQEHLFVPLELTKDEFRVVVSDPLDFLLLDSLKKMNPDRRMVVCLARRENIQGWLQEHFQGKTPGFTEEGDNEEAQTDASTDVSYLSEDLEQLRDLASEAPVIKRVNRIMTGAVEKKASDIHLEPFEGRIQVRYRIDGILQKFMEMPGHMHQALATRIKIMAGLDIAERRVPQDGRIRSRIAGKDIDIRVSCLPTVYGESVVMRILDRSSASFTLEQLGFPGREYQLFQELIHSPHGIILVTGPTGSGKTTTLYAALNAINSIQKKIITVEDPVEYELEGINQVHVNPRYGLSFADGLRSIVRQDPDVILIGEIRDRETADIAIQSALTGHLVFSTLHTNDAAGAVARLMEIGVEDYLLASSIIGIMAQRLVRILCPECRQPFSPEARILKKYDLAADNDLPQELYQPAGCPACSHTGYSGRTAIFELLGITEEIRELIIGNKSAAQIRNAGVKQGMTLLRRDGWNKVKQGVTSIEEVLRVTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKU9</accession>
    <name>D6SKU9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868442.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35310">
        <property type="protein sequence ID" value="EFI35310"/>
        <property type="gene ID" value="Dthio_PD2725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="124" mass="13852" checksum="143051060B6882E5" modified="2010-08-10" version="1">MVRDIGGGNLCMGDNLRIRRILVRCTGFLCIELDPDIFFVAIVLSIGIMGIGHGRSLSFLIYLDFDLALIIRVHLFIDEAQYQLIRKKGFKSAQRPREIYNIASSGHVSGQIPLFSTMPLGNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL84</accession>
    <name>D6SL84_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaerobic cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868577.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2865"/>
    <dbReference type="EnsemblBacteria" id="EFI35445">
        <property type="protein sequence ID" value="EFI35445"/>
        <property type="gene ID" value="Dthio_PD2865"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1100154at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016852">
        <property type="term" value="F:sirohydrochlorin cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010388">
        <property type="entry name" value="Anaerobic_Co-chelatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06180">
        <property type="entry name" value="CbiK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087967" evidence="2">
        <location>
            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="352" mass="39807" checksum="94DD57EFC9B43774" modified="2010-08-10" version="1">MRQVLLSLTLLLLPMFMMIQGCHAHSHGHDHDHDHDHDHGHEHHHHDEDKDMKKGILLAAFGSSYPQAQPALDNIEKMTKEAFPEVPVRWAYTSRMVRHSLAKKDKHFDSPAMALARMEDEGFTHVAVMSLHTIGGVEFHELRSVVGAFQDMQSNLKQVSLSSPLLGSPDVMERVRDSMLDNLPADRKADEAVIWVGHGSYHPSNAFYQALAYKLQRKDENVFMATLGCLGGSPSFEDVKEEVKAKGIDKAYLVPFMSVVGAHTIRDVAGKDNSGHDHSHDHGHEHNHDHEHNHSHDHGHDHDHDHHHGDPWKQRLQDAGIETEVVLKGTGEYDDFVNIWLDQLKKAVEQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLM4</accession>
    <name>D6SLM4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0846</name>
        <name evidence="3" type="ORF">Dthio_PD2591</name>
        <name evidence="4" type="ORF">Dthio_PD3013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868714.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0846"/>
    <dbReference type="EnsemblBacteria" id="EFI33512">
        <property type="protein sequence ID" value="EFI33512"/>
        <property type="gene ID" value="Dthio_PD0846"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35189">
        <property type="protein sequence ID" value="EFI35189"/>
        <property type="gene ID" value="Dthio_PD2591"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35585">
        <property type="protein sequence ID" value="EFI35585"/>
        <property type="gene ID" value="Dthio_PD3013"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7QT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1217533at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025639">
        <property type="entry name" value="DUF4338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14236">
        <property type="entry name" value="DUF4338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4338" evidence="1">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="292" mass="34093" checksum="6BE734AD55EFF4A4" modified="2010-08-10" version="1">MQTILRYRGRDITEEDVRFIRQLIFEHPGDSRWALSKKLCTAWNWVQQNGQLKDMVCRGLMLALHRQGHIILPPAQKVTATGYNRKEPVSVQVDQTPLTSSLKDITPLEFRQVRKTPFEGLFSSLLKEHHYLGYTQPVGEHLKYLVFANKQPIACLSWSSAPRHIGVRDNFIGWTQKDREKNLFLIAYNSRFLILPWIQVSCLASHILAQMTKIVQRDWESIYKHPIYYLETFVDQERFKGTCYFAANWLYLGQTTGRGKNDHTGKANRSLKAVLGYPLTRDFRKRLRGLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLQ0</accession>
    <name>D6SLQ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheW protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868740.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3040"/>
    <dbReference type="EnsemblBacteria" id="EFI35611">
        <property type="protein sequence ID" value="EFI35611"/>
        <property type="gene ID" value="Dthio_PD3040"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="16980" checksum="F41DD0CE87E74BBA" modified="2010-08-10" version="1">MQGKSSKASDRKDPFQISCFYIGDAMCGIDINLVQEINKQLDFTVVPHAPEYVMGIMNLRGKIVTIIDLSKKLGFSFSRMGDETRIIIVESKDEFIGLLVDKVTDVVLADWEKVSSPPSNIKGLKGKYFQGVYKSRTKLVAILDIEEVLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLU6</accession>
    <name>D6SLU6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3086"/>
    <dbReference type="EnsemblBacteria" id="EFI35657">
        <property type="protein sequence ID" value="EFI35657"/>
        <property type="gene ID" value="Dthio_PD3086"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088243" evidence="1">
        <location>
            <begin position="20"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="282" mass="31918" checksum="AA0459C8DDBC7FE3" modified="2010-08-10" version="1">MKYLLTLLMVLCLAAVAGAGEKDQGEKRDYVRHIGTGSMNWTEGRVHSTGSSRMQEMEDRTKSARAAERKALVKARKKLLENLQQINVDSSITVEDLSRENPETAGRLQTLVHHSKVWDTVYYHHPEGEVEVHVFLDLLDQDVQRMLPGRVFAGPQWKRNGNVVVELTPYCPLYIDATGLSARPSLIPAILDRDGNILYRASVLGERPGADRGHVRYMRVDKDQNITRLYESGPDGFKIEPERTNGRHDSDFVLSWEDTLEFQDIMDSIPEGCPVIIMMGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLX3</accession>
    <name>D6SLX3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868813.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3113"/>
    <dbReference type="EnsemblBacteria" id="EFI35684">
        <property type="protein sequence ID" value="EFI35684"/>
        <property type="gene ID" value="Dthio_PD3113"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="147" mass="16704" checksum="9C87987E4C58EE67" modified="2010-08-10" version="1">MLETIKEIIHQNDLAVLATSHEDRPHCSLMAYVPDSDCTRIYLLTLKDSRKFANISRNPYVSLLVDTRDPHEPRKDYKALTISGTCAPADTTEQEKLRQDMVKQHPQLKELADKPDCVLLVVNINSFLLLDGVSTAHYIELDDQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM91</accession>
    <name>D6SM91_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase (Ubiquinone) 24 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868931.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3237"/>
    <dbReference type="EnsemblBacteria" id="EFI35802">
        <property type="protein sequence ID" value="EFI35802"/>
        <property type="gene ID" value="Dthio_PD3237"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="161" mass="17911" checksum="0122188BF1EBD17F" modified="2010-08-10" version="1">MKLEDMNFDEKMGELGAIIGEEERKRGILIPALHEIQNKMGYLDPEELKELSKSLNISLTEIYSVASFYKMFHFKPRGKKIVKVCFGTACYVRGAKVVLDSLSEEFDVKDGETTEDLTMTLETVGCVGCCGLAPVVTCNEEVVGEIDGKKLDAFIDSVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMA1</accession>
    <name>D6SMA1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868941.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3247"/>
    <dbReference type="EnsemblBacteria" id="EFI35812">
        <property type="protein sequence ID" value="EFI35812"/>
        <property type="gene ID" value="Dthio_PD3247"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="859969at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023800">
        <property type="entry name" value="Cucumovirus_coat_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037061">
        <property type="entry name" value="Lytic_TGlycoase_superhlx_L_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012289">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008939">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00760">
        <property type="entry name" value="Cucumo_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14718">
        <property type="entry name" value="SLT_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48435">
        <property type="entry name" value="SSF48435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087881" evidence="3">
        <location>
            <begin position="26"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Cucumo_coat" evidence="4">
        <location>
            <begin position="149"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_L" evidence="6">
        <location>
            <begin position="405"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="5">
        <location>
            <begin position="482"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="653" mass="74860" checksum="AD854316CD2B49A8" modified="2010-08-10" version="1">MELKKSLAICAAALFFILSITPSSAGIQQERQDFLDAEKALQENRLDEFQSLSAGLIDYPLYPYLVFEELRENISISRESDILAFLRDYQQTPLASQLRSRWLDHLAGNQEWSRLARDFQAGSSREKTKCSYGRALLETGQKDAAFEHAEKMWLHGRSRPDECDPLFNAWRDEDRLTPELVRERIALSIDQGQLGLARYLGRYLPEQDKPWLDLWLDIARDPSLTPDQDWSQAAGTPQGKILVYGMKKLVRKDTPDAADDWDHILEKNQLDRKDFPEVEQDIALYLALRRHDQALQRFQDLPDDLKTPRLREWHVRTALYEQKYSEVLDAWDNLSSSQKSSPRWQYWRARALEEQGLVQQASGIYLGLLGRQNYFSLLAADRLGQAYSLNHSPLDPHPEKIDDLKSAPGIQRSLELYYLDREIQARREWMHALQGKDREMMAAAAVLARSIGWHDRAIQAAAGARQFEDLALRFPLSYHDLIAEHAGSRALDPAWVLALARQESMFMPDVRSPAGAIGLMQIMPATGRTIAARLQESLNNPHRLTDPATSVRYGVFYLDLRLQELQQNPVLATAAYNAGAHRVKRWLPKSQNIPADIWVESIPFNETRDYVERVKTYTTIYQIRMGMEPTRVYQRMPAVLPGHLAAEQVAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SME0</accession>
    <name>D6SME0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868980.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35851">
        <property type="protein sequence ID" value="EFI35851"/>
        <property type="gene ID" value="Dthio_PD3290"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503239G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1954291at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="9891" checksum="2CA15BFFE0021F85" modified="2010-08-10" version="1">MNICHFCGNSNFKDTVCEYTYKRDGRMLFVENVPCRKCGFCGETYFLSENLRKIEAEFEAIHYHGKKATGEIVVPTQHFADITSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMH7</accession>
    <name>D6SMH7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amphi-Trp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869017.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3327"/>
    <dbReference type="EnsemblBacteria" id="EFI35888">
        <property type="protein sequence ID" value="EFI35888"/>
        <property type="gene ID" value="Dthio_PD3327"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DZF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1958428at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20068">
        <property type="entry name" value="Amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amphi-Trp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="11079" checksum="5BC42541C3F4EF7D" modified="2010-08-10" version="1">MTEEKKFFLESLQDKETICKYLDALKEGFQQGSIHLSSNEQTLDIEPSGLIKFTIKGKKKDGEIKLNLRFRWTDEDDLPELDDSWNHSEKDSRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMJ6</accession>
    <name>D6SMJ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Dthio_PD3346</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869035.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3346"/>
    <dbReference type="EnsemblBacteria" id="EFI35907">
        <property type="protein sequence ID" value="EFI35907"/>
        <property type="gene ID" value="Dthio_PD3346"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="250"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="16">
        <location>
            <begin position="328"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="545"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="16">
        <location>
            <begin position="623"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="705"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="967"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="1120"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="17">
        <location>
            <begin position="1339"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1291"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="661"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1208"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1021"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1169"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="8">
        <location>
            <position position="1378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFI35907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1437" mass="160040" checksum="46844CC8D1BE3C7E" modified="2010-08-10" version="1">MNKLKLTTSLNTNRLLLTAAVIWIAVLAVSLAWNWHQVENTTRTLAENEARAYFEKDIAYRHWAAMHGGVYVQPTETTPPNPYLDHVPDRDVTTTGGKDLTLLNPSYMTRQVHALGLQHYDMLGHITSLNPLRRENAPDQWESQALLSFRQGEDRVSSVEDITGQQYLRFMEPLKTQESCLGCHGHQGYAVGDIQGGISVSVPWEPYMAQGAKQKTDLGIAHALIGVLGLLGLGMGYRLVRHSEMQLLESRDHTAATLHAISDGVFSCDKLGRIQEMNPAAENLTGWTIDECMGRPLKEVFNIVTLDDHSQEENPVSKALQQGRVVGQETYSVLIVRNGSKITIKKSCSPIKDNMGNIIGAVLVFRDITGEHTANLLTMKRLELYEYAEAHSLDELMTKVLDDAEEFVDSSIGFFHFVEKDQKTLSLQRWSTRSLKELCHMPGNKMHYPIDQAGVWVQAAREKRPVIHNDYESMPDKKGLPEGHARVIREAVVPVIRDNRVVAIMGLGNKPAAYDKKDVEVISFFADVTWDLVQQKRTQEALQNSQARLKTITDAAQTAIIMMDAQGYVSYWNPAAETILGYARDEAIGRDLHELIMPSRYTEDFHASFPEFQSTGQGNAVGRTTELYALTKNGREIPVELSLSSVLIQGQWHAIGIVRDITEKKQAQEELQRNARNLELKNAELDAARINAEEATKAKSEFLANMSHEIRTPMNGVIGMTGLLLDTDLDSEQQHYARTVRSSAESLLTVINDILDFSKIEAGRLDIETVDFDLEAMLRDFSGMMAVKAEEKGLELICSMDPNVPSMVRGDSGRLRQILMNLVGNAVKFTEHGEVEIKVSRMVNDECENPNAETQENSHDLYRSSFTTQHSCLMHFSVRDTGIGIPEDKQDSLFESFSQVDASTTRKFGGTGLGLAISRQLAEIMGGTAGLESVEGRGSTFWFTVRLGIQHEQQQERPAPACLQGVRTLIVDDNSTNRETLRVRLGSWGMRSEEAANGSTALSMLHQAKADNDPFEVAVLDMQMPDMDGETLGRNIKEDGQLKDTRLIMMSSATGQTGDAKRLHEAGFDSIMNKPVLPSELYACLEKILAKTDTADLVAEHAEREETPKGYPDFSGTKARILVAEDNMVNQQVALGILKKMGLRADAVANGREVLHALQNIPYDLVLMDVQMPEMDGLKATRRIRASEVRGQKSEIRSQKSEVSDQRLESESQNSSIPESPNSSTPKSPNSSIPESQNPRIPIIAMTAGAMQEDRERCIEAGMDDYTAKPVNPDELARVLEKWLLENRGQRAEDRSQGGKEEVLRTGEAAETKQEPRYAFTCKMPVFDQEDFITRIGHDSEMASEIMSIYLESIPKNIEALKKFIEQGQKEGATREAHSIKGNSGNVSCLAMAEIAGMIEEAGHAANLEQMGNLLPELERQFEICMAEIRKVMEEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMX4</accession>
    <name>D6SMX4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3477"/>
    <dbReference type="EnsemblBacteria" id="EFI36035">
        <property type="protein sequence ID" value="EFI36035"/>
        <property type="gene ID" value="Dthio_PD3477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="9882" checksum="CA3613A54DEA20CD" modified="2010-08-10" version="1">MELRRVHLNGLRANDLDDGKHFSDRPKSGRQSEAATYTSRAGTPLEIVSKVILLSSSMPIPNTSEAFLFQWIYLSCASLSTTPTSIDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN51</accession>
    <name>D6SN51_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869507.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1525"/>
    <dbReference type="EnsemblBacteria" id="EFI34177">
        <property type="protein sequence ID" value="EFI34177"/>
        <property type="gene ID" value="Dthio_PD1525"/>
    </dbReference>
    <dbReference type="OrthoDB" id="489066at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="605" mass="68133" checksum="6E5C328CCE214D06" modified="2010-08-10" version="1">MSFEFHTHLDISVDTRYNELFTDTEELYTHYEVWTGHIQEDGEVVDGNFLGRLSIEDLADVRVGYDQINHNAMYVRGWEDETGTGDWHHNDWKDGDYFDFPGPPEIEFHTDVDISLETSFADLFTDEDDTSTWYQIWTGEMDEEGVVQGSLVDTEEGGGWVRAEDLNNLLFTADQDGHNTVYVQSYSPEQGKGDWQHNDWQESRYFDSPEFPEAVLHSFPSQVMQANPDIEFNTDLNVTAGVTTFDELFTDPDESVVWYQLWTGKIDAEGEFIKGSFVDTPAGRGWIEASDLETLKVTAAHVDHNSLGVKAWSEEHGIRDMQFNDPDKPFTIDLLNAELELQGLRWKCQGIDFCTVPVEVAAGEKLNVTGTLAALNDGLADAEDVDFSLVILDADGEVEHEFTISEDDDFIPAGRSVDFNYAWYIEEPGDYTAEVTSSADNARSVQISEHFTVEHQEPGLRFQELEWTSNGKKFNTNHGLEVGEELTVSGKLAALEGYRENAEDVELNLVITGGARSDVSVEGYTVGDMKPGDSHEFELSWTSEYDYDPGQHPYYTLKIVADADNVDTVDNFRTFDVKAPEAASDDHIHTLGVSDDNARNEMEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNE4</accession>
    <name>D6SNE4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fumarate reductase/succinate dehydrogenase flavoprotein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HdrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869598.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1621"/>
    <dbReference type="EnsemblBacteria" id="EFI34270">
        <property type="protein sequence ID" value="EFI34270"/>
        <property type="gene ID" value="Dthio_PD1621"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="415" mass="45461" checksum="7F0DD3C5ECF812CE" modified="2010-08-10" version="1">MSNNSILVIGGGFSGLTAALEAAEVGHEVYIVEQEPYLGGRVAQLKHYFPKLCPPTCGLEINFQRIRKNPRVKQFTMAQVTQVTGGPGNYEAKIKVKPRFVNSNCTACDKCVEVCPVERDSDYDFGMGKTKAIYRPHLMSFPMRYVIDDQVCEGSSCAKCVDACEYQAIDLDEKEREFTLNVGSIIVATGWKPYDVSKLTNLGGGQIPNVISNMQLERLAAPAGPTDGQVLRPSDGKEPKRIAFVQCAGSRDQNHLDYCSYICCMASLKHCTYIREQYPDAEVVIYYIDLRAPGRYENFLSKIQQDEKVQMVKGKVAKITEDTATGDLVVTAEDIMGGVKKEEKFDLVVLATGMQPSISIDGLAVEVPRDESGFITGGEEKGIFPVGCAKMPLDVMTSAETATGGALNAIQTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNT7</accession>
    <name>D6SNT7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869735.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1771"/>
    <dbReference type="EnsemblBacteria" id="EFI34413">
        <property type="protein sequence ID" value="EFI34413"/>
        <property type="gene ID" value="Dthio_PD1771"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8559" checksum="4CCF34B34DBF70AD" modified="2010-08-10" version="1">MKKEYDFSKMKSRRNPYASKLKRQVTIRMSDDVVEYFKQLSEETGIPYQSLINLYLRDCMAHGRKPDLSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNW2</accession>
    <name>D6SNW2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869760.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1797"/>
    <dbReference type="EnsemblBacteria" id="EFI34438">
        <property type="protein sequence ID" value="EFI34438"/>
        <property type="gene ID" value="Dthio_PD1797"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1953609at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="SSF64076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="113" mass="12588" checksum="C7A3BB72BF88183F" modified="2010-08-10" version="1">MIEAYSFGKMRIQGKDYTQDLKIIKGGVVPRWWRKSGHSVETDDVRDILEAAPDILILGKGRPGVMQSTPELRALLQQKGIELVEAGTDKALEEFNRRFSSGENVAAGFHLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNY7</accession>
    <name>D6SNY7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">Dthio_PD1822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869785.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1822"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="EFI34463">
        <property type="protein sequence ID" value="EFI34463"/>
        <property type="gene ID" value="Dthio_PD1822"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="202" mass="22300" checksum="9FB58EF488AFBBE3" modified="2010-08-10" version="1">MSYNIPMVIESTGRGERAYDLYSRLLKDRIILLGTPIDDHVANLICAQLLFLESESQEREINFYINSPGGSVTAGLAIYDTMQYISAPVATLCLGQAASMGALLLAAGQSGMRYALPHSRILIHQPMGGFKGQATDIDIQAKEIIRLKSKLNNILAHHTKVDLAKIEHDTDRDYYLEAQEAQDYGLIDSVLTSRSEIDKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP19</accession>
    <name>D6SP19_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869817.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1854"/>
    <dbReference type="EnsemblBacteria" id="EFI34495">
        <property type="protein sequence ID" value="EFI34495"/>
        <property type="gene ID" value="Dthio_PD1854"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="34414" checksum="BFC8747BC488FF45" modified="2010-08-10" version="1">MKSINPVIEAISLGKRFGQFTAVDDVSFQVEEGEFFGLLGPNGAGKTSVIRMMYGFSPLSSGNIKVFGLDIKTGWRHIRSRIGVCQQENTLDPDLSVEQNLLVFAGYYRIPRQKAAERTRELLDFFALNHKKDARVSQLSGGMARRLMLARSLINEPGLIILDEPTTGLDPQSRHQVWDKLKELQTRGLTLVLTTHYMEEAASLCHRIVIMDHGRILVQGSPDGLIREFAGTSVIEVESPGQELQSFVEQKKINHEQLAGRLIIYTDDLNGLGKVIRQKFCPDKCLFRSGTLEDVFLRLTGRELRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP35</accession>
    <name>D6SP35_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1870"/>
    <dbReference type="EnsemblBacteria" id="EFI34511">
        <property type="protein sequence ID" value="EFI34511"/>
        <property type="gene ID" value="Dthio_PD1870"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="218" mass="25375" checksum="C97CBA53F3F1BEDF" modified="2010-08-10" version="1">MEDNNCEMKSLVAYQRIRDMIISREKFPGTRLVISDLEDELGIGKGPIREALMRLDRSGLVRNIPYKGAVVAEAPRMREIEAIYEMRAKLETTLALEAMENVDEQDIANLESILSEMDPELNLHELYHLDRYFHSQLYGYSRLPHLCLVVDKLMESVDIFLINRPRGSKYLIQMQAQHNQIIDALKNKDETMLKKSLKHNIKHGLRLIKKAYGPYMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP48</accession>
    <name>D6SP48_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869844.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1893"/>
    <dbReference type="EnsemblBacteria" id="EFI34524">
        <property type="protein sequence ID" value="EFI34524"/>
        <property type="gene ID" value="Dthio_PD1893"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="11238" checksum="25B33FAE944C6858" modified="2010-08-10" version="1">MSFRFHPEAERELREAVAYYEDIEPGLGYDLSVEVYAAVQRAVMYPKAWPVLDGDIRRALVRRFPYGVLYSEEQGVLLIIAVMNLHREPGYWKGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP55</accession>
    <name>D6SP55_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869851.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1901"/>
    <dbReference type="EnsemblBacteria" id="EFI34531">
        <property type="protein sequence ID" value="EFI34531"/>
        <property type="gene ID" value="Dthio_PD1901"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="912543at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_4" evidence="2">
        <location>
            <begin position="297"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="486" mass="53737" checksum="44E68AF96199DB7F" modified="2010-08-10" version="1">MTPSELTSLLARGEDSRHQFKRNATNADGLAAELAAFANSGGGWLFLGVNDDGSIAGLNAADIRRLNQLLGNSASQHVRPPLHPLSENVQTDQGIVMVVEVPDGLAKPYLDNQGRIWVKQGADKRHVTSREEMQRMFQRAALLYADVVPVAGTSVEDIDDKAFSAYFDRRYGASGEFSGLTREQLLQNLGLGDGRELNLTGLMLFGRNPQRWRPAFEVKAVAFPGKVLHDTRYLDSEDIKDALLEQFRGAFAFIKRNLHHVQRGRGFNTPGELEIPEIALEELLVNALIHRDYFTSASVRVMVFVDRVEIVSPGHLPDSLSPEDIRQGKTIRRNPTLTEHASHILPYRGMGSGIPRALEAWPQIDLVDDPAGNQFSAVIWRAKAEWSVDTAAPQVTGEVTGEVTGGVTGEVKRLAEAMQGEMKRSEIQAALGLKHEDHFRESYLRPALDAGVIEMTIPDKPRSSRQKYRLTALGQALLKAGQEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPD4</accession>
    <name>D6SPD4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopG domain protein DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869930.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1982"/>
    <dbReference type="EnsemblBacteria" id="EFI34610">
        <property type="protein sequence ID" value="EFI34610"/>
        <property type="gene ID" value="Dthio_PD1982"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503399Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040377at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038296">
        <property type="entry name" value="ParD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8699" checksum="C35BD42D8A34CB2A" modified="2010-08-10" version="1">MSRLTITLDDELHRALKETSARQGRSINKIIEESLHMRGIKSMDDARQLVAHARSQANCSEEEAMALSTAETRAFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPF6</accession>
    <name>D6SPF6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly PilZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869952.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2004"/>
    <dbReference type="EnsemblBacteria" id="EFI34632">
        <property type="protein sequence ID" value="EFI34632"/>
        <property type="gene ID" value="Dthio_PD2004"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846620at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="80"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="180" mass="20839" checksum="9B10DBA2C4474E22" modified="2010-08-10" version="1">MKTQDRKYSRVNTRIKAYMRRTVFDDSLPLFSSTLVGDTDDHAVKNLYGSHLPRELINFLQQMDEKVNMILSLINRETIQADFPLQGEVLEISGAGLKFTSQEDFEEGENMEMVLLLSQVPLRIVGMVGRIHRCEKVQGVPVWAVQYASIRDVDREKIVQFVFQEQREHIRGRKNENEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPJ8</accession>
    <name>D6SPJ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869994.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2046"/>
    <dbReference type="EnsemblBacteria" id="EFI34674">
        <property type="protein sequence ID" value="EFI34674"/>
        <property type="gene ID" value="Dthio_PD2046"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1730305at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="214" mass="24989" checksum="CBE6F3CA89D8881C" modified="2010-08-10" version="1">MGTHCRVCLGKELDFFYRQEDLVYWSCSSCQAVLLDEKKLPDAHEELKRYQEHNNYPVDAGYRNFLNRLASPLLQKIPGRSLGLDYGCGPGPALSVILKKAGHRVELYDPFFYPDKIVLEQKYSFITCSEVVEHFHRPYEEFVRLDKMLCPGGWLGIMTCFFLPGHDFGQWHYRRDPTHVVFYQPQTFHLLAGMFGWSCEIPVPNVVLMQKNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPL5</accession>
    <name>D6SPL5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoheptose isomerase</fullName>
            <ecNumber evidence="9">5.3.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sedoheptulose 7-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmhA</name>
        <name evidence="11" type="ORF">Dthio_PD2063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.28" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870011.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2063"/>
    <dbReference type="EnsemblBacteria" id="EFI34691">
        <property type="protein sequence ID" value="EFI34691"/>
        <property type="gene ID" value="Dthio_PD2063"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1571626at2"/>
    <dbReference type="UniPathway" id="UPA00041">
        <property type="reaction ID" value="UER00436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008968">
        <property type="term" value="F:D-sedoheptulose 7-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001061">
        <property type="term" value="P:D-glycero-D-manno-heptose 7-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00067">
        <property type="entry name" value="GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004515">
        <property type="entry name" value="Phosphoheptose_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="38"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="205" mass="22001" checksum="DB321D9ED0CFEAFC" modified="2010-08-10" version="1">MQDKSLDIIHAHARDGSRARDAFFEKNALELAAISRTIAASMVAGGKVLFCGNGGSAADAQHLAAEFVNRFLLERPPLPAIALTTDTSILTAISNDYHFHEVFVKQVKALGRSGDILVGISTSGGSDNINKALHQALELDMVTVGLTGKKGREPMQACCSHLLVVDEESTPIIQEVHIAAGHILCMLVDHYLFEKPQESKKGQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPN9</accession>
    <name>D6SPN9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870033.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2088"/>
    <dbReference type="EnsemblBacteria" id="EFI34715">
        <property type="protein sequence ID" value="EFI34715"/>
        <property type="gene ID" value="Dthio_PD2088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="181" mass="20443" checksum="B4B0ED64C1240FFB" modified="2010-08-10" version="1">MKDLIISLSIYLSGAVKPGARTFSRQSVSMLAVFLCLSIVGAGLTGCGLRRGDPPPAEMTLRIEPDASANSGRIFYLMVRSTDEKQYLEHTYSHVASKVFGDPADPDILGVFPILPGRDEKIDVVQPRQNPVAFYFLFSEQSDDWRHLMPQPLDDTYRISIQDQSVVIEGRRSIFRRFQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPR6</accession>
    <name>D6SPR6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870060.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2115"/>
    <dbReference type="EnsemblBacteria" id="EFI34742">
        <property type="protein sequence ID" value="EFI34742"/>
        <property type="gene ID" value="Dthio_PD2115"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="456" mass="48777" checksum="94B006B135B5EEE7" modified="2010-08-10" version="1">MTNFIILVYLAGVLIIGILAGRGIKNLSQFAVAGKAYGSMVIFATLSASFIGGGFSMGNAEKVFLFGIVNIVALWGFSLKEILVAGYIAPRMDRYRDAISVGDIMEVHYGKTAKVFSGLFGFILCAGILGAQIGAIGYITNVFLGFERFWGILLGCSIVIAYATAGGMKAVVWTDIVQFIILAVGLPMTLFMGIQSAGGVEHIISTVPQGHLSISLEPAAVIALFSLFLAFVVGETLVPPYLQRLLIGRNASQVVRGTLYSGLFSIPFFAVTGLIGMVALVLNPELNPNLAMPYVVQQALPPLLQGIVIAAVIAIIMSSADSFLNAAAICFSNDMVKPFRRTPMSRESEVKMARCVTLLVGVMAVVFALSIESVLDILIYAYNFWAPIILVPLVMAIMQRRVSSTKFLGGAGAGIAALLIWNYVLNGPWEIHGIVVGFFANLLVFILLDREKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPY1</accession>
    <name>D6SPY1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34807">
        <property type="protein sequence ID" value="EFI34807"/>
        <property type="gene ID" value="Dthio_PD2189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="42"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="232" mass="27082" checksum="8B8605A9E25B204A" modified="2010-08-10" version="1">MVRSDPKESKGWVIPPEQNGNFVAHMEHVLDIYKRSFDPLYPVVCMDESPKQLISEKRTPIKASPGKPARHDYEYKRCGVCNIFIAFEPLAGKRLVKITERKTKQDWAFFLKDIDEQYQEAKKITLVMDNLNTHGPGSLYDTFPPDQAKSLWDRFDFVYTPKHGSWLNIAEIELNVLHGQCLNRRIDDIEIVRKEVSAWQNMRNNNTAQVNWQFTAENARVKLHRLYPTFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPY9</accession>
    <name>D6SPY9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870131.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2199"/>
    <dbReference type="EnsemblBacteria" id="EFI34815">
        <property type="protein sequence ID" value="EFI34815"/>
        <property type="gene ID" value="Dthio_PD2199"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZPSG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2231837at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="196" mass="21926" checksum="1D1CC18E45CD0613" modified="2010-08-10" version="1">MTTVDMNRFNFLIASIQDMQSTIRAVDTKLTAILVVLVLPVTQSQVFAKSLSHTWSQAGTGCKVIIAGLVITFALFWLATFVSSILGLWSSNNPAKMVSGANKVNGSFFLGGIYHFKWWHGFIKNQNIKSKISISECLENLPDENSIIDELVFEQMKLAYIRDKKISHQKAAYHCLIGGLIFGFFVWLILFEGLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ13</accession>
    <name>D6SQ13_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="9">DHOD</shortName>
            <shortName evidence="9">DHODase</shortName>
            <shortName evidence="9">DHOdehase</shortName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrD</name>
        <name evidence="11" type="ORF">Dthio_PD2230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="9">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870153.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2230"/>
    <dbReference type="EnsemblBacteria" id="EFI34839">
        <property type="protein sequence ID" value="EFI34839"/>
        <property type="gene ID" value="Dthio_PD2230"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="10">
        <location>
            <begin position="5"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="304" mass="32029" checksum="5DF2CD0C3DA2F81C" modified="2010-08-10" version="1">MDISVDLGGLRLKNPIMSASGTFGYGLEFSPYGDLQKLGAIVVKGLSLHPRSGNPTPRITETPCGMLNAIGLQNVGVEKFLAQKLPFLPADETPVVANLYAQGAEEFVELAAILGDAPRVGALEVNISCPNVRCGGVQFGQDPEAAASVTREVRRASPDKPLIIKLSPNVTDIRVIARAVRDAGADVISLINTLGGMAVDIHSRKPRLANIVGGLSGPAVKPVALKMVYEVCSEVDIPVIGLGGICNARDVLEFIMVGAHAVQVGTANFMRPDLIFDLVDELPGLLAELGAESLEDFRGSLETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ15</accession>
    <name>D6SQ15_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="13">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rlmN</name>
        <name evidence="15" type="ORF">Dthio_PD2232</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="13"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2232"/>
    <dbReference type="EnsemblBacteria" id="EFI34841">
        <property type="protein sequence ID" value="EFI34841"/>
        <property type="gene ID" value="Dthio_PD2232"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="85"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="13">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI34841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="332" mass="37213" checksum="9B469734886E9F84" modified="2010-08-10" version="1">MQNLLKERGEPAYRADQLWQWIWQKKAGDFQEMTNISKALRSSLQQEFVLQRPAVVQKKESIDGTVKLLLGLNDGFFIETVIIPEKDYYTQCISTQVGCPMGCVFCSTGCMGFKRNLTPGEIASQVLVACRHLEDTGLDSTRLTNVVLMGMGEPLLNWDAVKKAMYMMTDSLGLGISRRRLTLSTVGVRDRLQEFGSSRLGMLAVSLHAPDQDLRRRLMPGAATWDIKDLVRALEQYPLAPRERITIEYVLLKDINDSPAQARALVRLLSRVKCKVNLLAYNPGEQEGYQPPQEKTILTFEEVLRSKGLTVTLRKSKGQDISAACGQLIADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ68</accession>
    <name>D6SQ68_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870208.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2285"/>
    <dbReference type="EnsemblBacteria" id="EFI34894">
        <property type="protein sequence ID" value="EFI34894"/>
        <property type="gene ID" value="Dthio_PD2285"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1813832at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="132" mass="15074" checksum="14D2719596FC2A9F" modified="2010-08-10" version="1">MTTAFLYALFALAAILVNLGTQMISFSLYQGPLDLYLALACGTFTGLLTKYVLDKRYIFRYISRDFCDDTCKFFLYSCMGVFTTLIFWGTEIGFHHLFEFEHAKYVGGALGLTIGYVLKYRLDKKWVFVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQD4</accession>
    <name>D6SQD4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">topA</name>
        <name evidence="12" type="ORF">Dthio_PD2352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2352"/>
    <dbReference type="EnsemblBacteria" id="EFI34960">
        <property type="protein sequence ID" value="EFI34960"/>
        <property type="gene ID" value="Dthio_PD2352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="10"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="170"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="752" mass="84860" checksum="464DEC096CC1178F" modified="2010-08-10" version="1">MLIRTNIMSKDLIIVESPAKVKTISKFLGKDYMVEASVGHIRDLPKKTLGVDEESGFQPEYEIIYGKKKVVNKLKQSAAKSARVFLAPDPDREGEAIAWHIAEEIKSKNANIHRIQFNEITSRAVQEALQNPRELNQSLFDSQQARRVLDRLVGYKISPLLWKKVKRGLSAGRVQSVALRMIVERERERQAFVPEEYWVFKVNLQTQALESFEAGLWKIAGKKAHVPSEKDALALEEKVRGASFTVQSVEEKERSRDPKPPFITSTLQQEASNRLGFTAKRTMSVAQRLYEGLDLGDKGTTALITYMRTDSVRVAKEAQQEAKSWIINNLGKDYYPKKTRFFKSKGSAQDAHEAIRPVDPSITPDEIKSYLSRDDYVLYNLIWSRFMASQMAAARFWDTVVTVKAADTLWRAKGERIIFPGFLRIYIPGGTQEDSLLPKLAKDEELVLENLSKEQKFTQPPARYSEASLVRRLEELGIGRPSTYAAIISTLLDREYVTLEEKNFRPTELGSEVCDLLVEHFPSLLDAGFTAQLEQDLDTIALGEKNWVEVMRSFTGEFYPTLEKAQKAMASVKGGKETDIKCDKCGETMLIRFGRNGAFLACSSYPECKNTSNFTRDDKGSVQLVENETVEREKVGTCPDCGGDLVIKKARTGSRFIACDNYPKCKHSAPFSTGIACPQDGCTGELVEKSSRRGKIFYGCNRYPECDYALWNPPVAKECPECGSKVLVQKNTKTRGQHLDCPVKGCKYWEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQD8</accession>
    <name>D6SQD8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870278.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2356"/>
    <dbReference type="EnsemblBacteria" id="EFI34964">
        <property type="protein sequence ID" value="EFI34964"/>
        <property type="gene ID" value="Dthio_PD2356"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="178"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="646" mass="71001" checksum="84DB8C8799F23830" modified="2010-08-10" version="1">MDSQRSIYLKTISIDEALEKVLEEITPASLPGRESVPSQQALGRVTAGPVRARYSSPTFHSAAMDGVAVRAESTFTAREDNPVILEKGRDYVEINTGNPIPDGMDSVIMVEKINQEYEHSISIEQPAYPWQNVRRIGEDIVATELLLPRNHEISAYDIGVLLSGGIWEVDVYQQVGIHVIPTGDEVLDFTSRPDPSPGQVIESNSQVLAAMAQSWGCRFSRTAPVPDEPQKLEKALQEALDSQAHIVVIGAGSSAGSKDFTRRIIQEKGRLLVHGLKAMPGKPTVLGISHNNKILVGAPGYPVSSVICFEQILKPLVYHLSGKTPEEPVTVEARLTRKIPSRLGMEEFLRVSVGRVGEQYVATPLPRGAGMMTTLTKAQGMTRIPADLEGMQQDRMIEVQLLRRSREVNQVLVTVGSHDNTVDFLANELALFNPPVRLASTHVGSMGGITAIRRGTAHMAGIHLFDPETGDYNFPFLDKYAPDLDYRLINLAVRHQGLMVLPGNPRNIRSLQDLPRDDVEFVNRQKGAGTRILLDHHLQQADISPEKVKGYSNEEYTHMGIAVNVLSRTADCGLGIKAAAQALGLDFVPLARERYDLLIPEDFIQDDKVVQVMNLLHSRDFKAGIESLGGYETTLTGREMKPGMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQE8</accession>
    <name>D6SQE8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterodisulfide reductase, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870288.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2366"/>
    <dbReference type="EnsemblBacteria" id="EFI34974">
        <property type="protein sequence ID" value="EFI34974"/>
        <property type="gene ID" value="Dthio_PD2366"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1319322at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="186" mass="21421" checksum="EAE54B61FFEAE15F" modified="2010-08-10" version="1">MEVVDIHASSDNEFIAKVEEESGQNVRLCYQCGNCTAGCPYTFVYDIPVSQIMRLLQAGQKQKILSSRSIWLCATCESCTTRCPNEIDVATIMDVLRHMARREGYVSEQKVKKFWDSFLDSVEKHGRVFEMGLLTRYITRTGRVWTDVDLAPKMLPKGKLSIRPHKIEGRDKVAQIFKRFREEAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQL5</accession>
    <name>D6SQL5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine/O-acetylserine sulfhydrylase</fullName>
            <ecNumber evidence="5">2.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870355.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2435"/>
    <dbReference type="EnsemblBacteria" id="EFI35041">
        <property type="protein sequence ID" value="EFI35041"/>
        <property type="gene ID" value="Dthio_PD2435"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="448" mass="48453" checksum="D6CE70D8DE2AF6BD" modified="2010-08-10" version="1">MSRKDWKTETISLHGGHTPDVATRSRAVPIYQSTSFVFSDSQDAASLFSLKPEVWAPRLNLDTEGLRPDDFAPEATGNIYTRIMNPTTDVLEKRMALLEGGVGAVATSSGSSAITYAVMNICESGDHIVSSSSLYGGTYNLFRHTLPRYGISTTFVDATSPQSFADAVTDKTKCMFVETVGNPGLDTPDLAELAATAHRAGVPLIVDNTVPTPVLCRPFESGADIVVHSLTKFCGGHGNSIGGVIVDSGNFDWKAPDRFYMLTQPDPSYGGVVWSEAVGRAAYIIRARTVLLRDTGACISPFNSFLILQGIETLAMRMERHSQNARATARYLKDHPAVSWVLYPGLDNHPTHEQARRYLQGGFGALVGFGIKGGLEAGRRFIDRLKLFSHLANIGDARSLAIHPASTTHAQLTEEEQKSAGVSPDFIRLSIGLEHIDDILADLEQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQN5</accession>
    <name>D6SQN5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Sec-independent protein translocase protein TatA</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Sec-independent protein translocase protein TatB</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">tatA</name>
        <name evidence="9" type="synonym">tatB</name>
        <name evidence="11" type="ORF">Dthio_PD2455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TatB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870375.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2455"/>
    <dbReference type="EnsemblBacteria" id="EFI35061">
        <property type="protein sequence ID" value="EFI35061"/>
        <property type="gene ID" value="Dthio_PD2455"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1907955at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00237">
        <property type="entry name" value="TatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018448">
        <property type="entry name" value="TatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01410">
        <property type="entry name" value="tatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="15374" checksum="3AF463A90029BA83" modified="2010-08-10" version="1">MFGIGTTEILVILVVALLVLGPKKLPEIARSLGKTLAEFKRVTTDVKRTIDLEAQEEEDKDRQTRLKKKMEKKAAKKKEAEPEEEIKDQSEEKPSPEPNPEESGQKEQAEEKAGSEEQEEPEKTAKENDKEAETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQS4</accession>
    <name>D6SQS4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870414.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35100">
        <property type="protein sequence ID" value="EFI35100"/>
        <property type="gene ID" value="Dthio_PD2494"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503431E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="714510at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="284" mass="33522" checksum="7B42EEF4F36A1336" modified="2010-08-10" version="1">MITSPDKLQACFQAAQDQRSKLIIVMPQEATSMDSLEASLEDFDENHLYLEISTLENYSNSWHDLEIICYFRLTQKKGPQKEMFFNFGARIVELAKKEKIVKMVLQRPQKLDIGQRRSSMRIEMDQNLMVNFCIWEEHRFIRPRTKDTKTGLYSPRINLDYIQEGSFSVVDLSAGGMKVRATSRLIKELELDWNRGLVLVIWMNLDDPEKAKSQDFWIKGRIRYSMEDFFSKDVDMGVEFTHYGQISPDKKMKWQAVRDHNIEPLGNWTYRRYMENYRKGVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQX0</accession>
    <name>D6SQX0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">Dthio_PD2541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870460.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2541"/>
    <dbReference type="EnsemblBacteria" id="EFI35146">
        <property type="protein sequence ID" value="EFI35146"/>
        <property type="gene ID" value="Dthio_PD2541"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029688at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="329" mass="34962" checksum="33530E1B1B0173B1" modified="2010-08-10" version="1">MTEALIILVLAFAMDLLLGDPVYRLHPVRLMGAAVSRVERLFFSQGLRGRGGGMILTAAMLSGVSILAAAGIFLASMVPGLEFIFMVFLVYSCMGLKDLVGHTRPIARALEEGDLGRARQKLQMIVGRDPSALDSSGVARAAVESVAENFVDGFLALAFWFVAGCILGQVLGVEPAFAGVLLAANYRMVNTLDAMVGYRSSRYMQFGRFAARLDDVLNHVPARLSILFISLAALACGYDWKGSLGTGLRDRLKHASPNAGHSEAAMAGALNIRLGGPVQYAFALVEKPWMGEKGQDAAWEHIQAALKVIQAAAWISLALAVAVLAAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR01</accession>
    <name>D6SR01_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module toxin, RelE/StbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870491.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2575"/>
    <dbReference type="EnsemblBacteria" id="EFI35177">
        <property type="protein sequence ID" value="EFI35177"/>
        <property type="gene ID" value="Dthio_PD2575"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10913" checksum="1826AD58209C1D36" modified="2010-08-10" version="1">MIWRVEFDDRARKELRRLDRQAQANILRYLRDRICTPEDPRRFGDPLRKNMSGFWKYRTGPYRIICDIQECVVTVRIVRIGHRKNIYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR22</accession>
    <name>D6SR22_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33138">
        <property type="protein sequence ID" value="EFI33138"/>
        <property type="gene ID" value="Dthio_PD0457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024524">
        <property type="entry name" value="DUF3800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12686">
        <property type="entry name" value="DUF3800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="326" mass="38381" checksum="B27684C7BDF69A9A" modified="2010-08-10" version="1">MYIFYVDETGNLDTHGIHPGMDYSASPKDWLYVLTALGIFEHNWRKFYDPIAAKKKILLQIHNAGQVSLDECEIKSNWIRINRERQKHPFLSLLTMEEVDDLVATYYNQLFSVPAVLVSVVIDKRYLQDYMDASKLHRKAWELLCERVENYMREKHRKHKAIMVTDDISRQANLSLARKHAYFLESGTSADCRFRHIVEMPLFVRSELSEGIQAADMCSYNIYHTMRYQRFDYEYFKKVFPLLYNSSNTNQSKVDGLKIFPDDSPLIPWWEKNKSLLAEALLFIDVRRGGPYRADKQHRTLSTLNIHAYFVKVYQAEFISLCFSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR78</accession>
    <name>D6SR78_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Negative regulator of flagellin synthesis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Anti-sigma-28 factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD0520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870552.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0520"/>
    <dbReference type="EnsemblBacteria" id="EFI33194">
        <property type="protein sequence ID" value="EFI33194"/>
        <property type="gene ID" value="Dthio_PD0520"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1979521at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007412">
        <property type="entry name" value="FlgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03824">
        <property type="entry name" value="FlgM_jcvi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FlgM" evidence="10">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="11537" checksum="202643B461BF032C" modified="2010-08-10" version="1">MQIKGFPTGIQTYEQSKTEKTKADKGSSQGSSQAQSGDRVTLSQGAKLHQTAMKAAGNSDEVRMEKVQNLKERVADGSYQPDARRTAEKMIREDLENWMGGATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRB5</accession>
    <name>D6SRB5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ORF">Dthio_PD0557</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0557"/>
    <dbReference type="EnsemblBacteria" id="EFI33231">
        <property type="protein sequence ID" value="EFI33231"/>
        <property type="gene ID" value="Dthio_PD0557"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="115"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="312" mass="35377" checksum="EB97145D87968BFB" modified="2010-08-10" version="1">MSWIADSLPDEATAFLAHLDVEKGFSGATLQAYSKDLLQWEEFLQTRNKTCASPQDIVRADVHAFLVQMHKLNLSKSSMARKLSSLRTFFRFLQKQKIIQQNPCTGVRNPKQEKPQPGVLNVDQALEMVQAQLEPSPRNTRDLALAEVLYGSGLRVSEALSLDLDDVDQGQSLVRVQGKGRKERLAFLTRPGLERLSQYIALRHAFEPDLREKALFLGMRGGRLHRREAVRIIQRLGQIFARAQGVSPHTLRHSFATHMLQAGADLRIVQELLGHSRISTTQRYTHLNLDQVMQTYDKAHPLAREKDKNQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRE0</accession>
    <name>D6SRE0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 domain protein beta Propeller</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870614.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0582"/>
    <dbReference type="EnsemblBacteria" id="EFI33256">
        <property type="protein sequence ID" value="EFI33256"/>
        <property type="gene ID" value="Dthio_PD0582"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087930" evidence="2">
        <location>
            <begin position="27"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="444" mass="49762" checksum="89E6C4B9A495FD33" modified="2010-08-10" version="1">MIKLRFFIFLSAIFLVVSLLPTRAWAQDSLHIDIFGPGEDRINAFVAPPRDLQSEVLHNPELGSRIYDGLQSNLGLLPFLTQVNPEHILGGPGVEGVRGRDIDFRKFNLSRVDLLLTIGLEQHAGGPGSVEIRAFEVFDQRMILGRAYDLQDLDQVPLMLRRFCAELMEYLTGNGDFFRSRLAFERKKNGNKDIWSVTPQGNDLTRLTDLRGITLSPAWSPDGSRIAFTLMRDNEHHLGIWDLEKGEEEVFSMPGNTVISPAFSPEGRLALSLDPMGRPDIYWLDDDYGVDETIMEHWAIDVSPSFDASGTKMAFASGRLGNPHIFVHDFEKGQIQRVSYEGRYNTNPSISPEGDFVAFTRQTPDGHRIFVVDLETGREKQISSGPGNDEDPAFAPDGYFVAFSSNRSGEYRLYLTTRNGDEPREISTGEGNAKAPAWGLEKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRG8</accession>
    <name>D6SRG8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD0610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870642.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0610"/>
    <dbReference type="EnsemblBacteria" id="EFI33284">
        <property type="protein sequence ID" value="EFI33284"/>
        <property type="gene ID" value="Dthio_PD0610"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="156"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="358"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="411"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="484"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="544"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="664"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="810"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1085"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1233"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="14">
        <location>
            <begin position="1386"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="947"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="947"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="1139"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="1282"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI33284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1562" mass="176024" checksum="4D34A9AC39E4DFA0" modified="2010-08-10" version="1">MNTGSSSQNKWLIHSQRLAAVLVLAGILLNVGLLSFMQIKPEIVVHTSMVIEGLFVFLVGGILIFIFCCRHTWMQGLENRFLVLFILGVGMLFLYAATDFASNFVLTASGDFVHVSVEIARLAAISLLVISAGLWIRDLMRTRQMLLRNEKRLEDSEQRFRDVAEAAGEYIWEIDPGGTYSFLTPRVEDVLGRRVDEVLGRSPFDFMPHEEARRVEKMLAGWAEKGESWQGLEHQSVRPDGRIIWQRVSGMPVKDSEGELKGFRGTGLDITAEKEARQATQELTERLRLATEAAELGIWDLRISDGYLEWDEGMFRIYGVSRDDFTNSVKDWTDALLPEYREQAEQDFKAGIAGQGAYRSEFKIRRKDGEIRHIRAMAQSIHDETGNPVRVVGINEDITEQKMAEQELRQERDYSSRIIQMSPAIICGISSDGTCNYVNPAGEKVTGYSAQELVGKDWWSTLYPGSSYEQVRQLFQDMQNGPVQNHEMTLTRKDGHERIVEWNSLNRLDQEENLLEVVGFGHDITDRRIAEEELFKRQDELEKTTRELEGFFDVTLGLLMIADFQGRILKLNRAWEDILGYPLNEIARSNLLDFVHPRDQEKTREAMSSLSRGEHVRDVVNRYQHKNGGYIWVRWQASSREGLIYASANDITESIMLQERLAQEKDFLQQIIDSSPNPIFAKDWHGRHTLANTRVAELFGTTKEAMLGKTDYDMTATQEEIQAFLQDDREVMQSGKQKHIPQEPLTDSQGQVRWFQTTKVPLMLSHDPKKRQVMGIATDITHRIESEHQVQLAREEAEAANRAKSDFLANMSHEIRTPMNAVIGLSQLLLQTSLDDRQRDYLNKISNSSRMLLGIINDILDYSKIEAGKLELDMHTFRMDELLDQMKTLFGSTAEDKGLEIIFNISTDVPRILKGDSLRLGQVFTNLLGNAVKFTEKGHVELAVHKSEVRSQESEVRDQGTEVRSQDLGQGTGDRGQGLEAADRDSESKIVRLLFEIKDTGIGMDDEQVQRLFQPFSQADTSTTRKYGGTGLGLVISHKLVQRMGGTLQVDSTPGQGSRFYFEIDLPMAPESETTQECIGFDSHRVLVVDDHEAARQVLRNILESCMFQVKEAHDGRSAVDAVVAADRAGEPYEFVFMDWKMPGELDGLQAAREIDRLYAEGFLKGNRPPFVVVSAYQRSELPEDSVECFNCFLSKPVTASSIFNAIAEATGKAPSYTRDDEQFTIPSFQGYSILLAEDNALNQEVAWQMLEKTGAALSLAANGAEAVEMVEAGSFDLVLMDLQMPVMDGFEATRKILERFPDLPVIALSAAVMEEDRNKSRQAGMRDHLSKPIESTSLYRTLARWLQAGDSVKVQKMEPEQDSSLLPRSLEGFDLAQGLRSADRDSGFYHRMLLRFREQLSGEFARIDEELDKGKSGDGPRLVHTLKGLAGTVGAVRLAEAASFIDLAFKENREITLELRRELDHAMHQARTELDGLEKAPGQSREVDQEEGVAAMSSMLQLLKNSEMVQDELIEAVTGFLRSRAGVEEVDELAGLVENFEHDAAVVKLLELASRSGVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRK3</accession>
    <name>D6SRK3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase</fullName>
            <ecNumber evidence="2">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870677.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0646"/>
    <dbReference type="EnsemblBacteria" id="EFI33319">
        <property type="protein sequence ID" value="EFI33319"/>
        <property type="gene ID" value="Dthio_PD0646"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="981229at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="268" mass="29719" checksum="544DC358F19317A6" modified="2010-08-10" version="1">MQIVGELINASRKSVGEAIKAQDVDTIKKLARDQAEHGADYIDVNAGIFVGKEKDYMDWLIKLVQEEVDVPCCIDSPDPLVVESALKLHQDKAGVPMVNSISLESERFDNLLPIISEHKCKVVALCMSDEGMPETAEDRFAIAEKLVNVLMQKGVKADDIYVDPLVQPISTNKMYGVEFLNSIEMIMTRLEGVHTVCGMSNISFGMPKRAILNRNFVVMAVLKGLDTAIINPMDANMMANIIVAETLAGKDEFCMNFLEAYRANKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRM3</accession>
    <name>D6SRM3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ORF">Dthio_PD0667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0667"/>
    <dbReference type="EnsemblBacteria" id="EFI33339">
        <property type="protein sequence ID" value="EFI33339"/>
        <property type="gene ID" value="Dthio_PD0667"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="72"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="162" mass="18490" checksum="B4C2C57C669EDF03" modified="2010-08-10" version="1">MARKVRVINGEGEQLGIMDTGQALDMAQSSGFDLVEVAPNADPPVCRIMDFGKYQYQQQKKKQEAKKKQSRVQVKEIKVRPKTDVNDLNTKVRHIRKFIEEGDRVKVSVFFRGREMAHKDRGADILNKVVEQTSDVARVEQEPRYEGRTMHLLLSPVGPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRN3</accession>
    <name>D6SRN3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870707.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0677"/>
    <dbReference type="EnsemblBacteria" id="EFI33349">
        <property type="protein sequence ID" value="EFI33349"/>
        <property type="gene ID" value="Dthio_PD0677"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="189" mass="21993" checksum="F939C9256CB62FF7" modified="2010-08-10" version="1">MRIFFGIPLPEVYQQMLGQARNEWKKRFRSRLSWTRPGNWHITLRFLGEVQDDLLPQVKVCLDRVEFEDFCLQGSKSGYFGSAGQYRVAWLGVDGEVQKLMNLARTLEKELEGFGFEPEKRPFKAHLTLARIKNFVADDPWKEFSDYVENMGWPEFNAERINLWQSRLTPAGPEYSVLAHKPLHRSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRN9</accession>
    <name>D6SRN9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine pyrophosphate protein domain protein TPP-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870713.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0683"/>
    <dbReference type="EnsemblBacteria" id="EFI33355">
        <property type="protein sequence ID" value="EFI33355"/>
        <property type="gene ID" value="Dthio_PD0683"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="57"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="317" mass="34519" checksum="3C773B98C0C1BB5D" modified="2010-08-10" version="1">MLNSSALENLEKITQKNMPREDMISPGHRACQGCAEVLAMAMVMKVAGPNTIVANATGCMEIITSPFPQTAWKIPWMHVAFNNTSAVASGIEAGIKALERKGRIPAKKPNIIAVGGDGATFDIGIQALSGALERGHNFLYLCLDNEAYMNTGVQRSSATPLGAMTTTSPVGSKFQGQQTWKKDMPGIAAAHNIPYVATANPGFHLDLMNKVQKALAVDGPAYLHVYSACPTGWRSKPEKSIEISKLAVQTNIFPLYEIIEGKLTITKNIKKPKPVVDYLKTQRRFAHLKEDDLKFIQEQTDANLARLKKLEADSSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRR8</accession>
    <name>D6SRR8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0715"/>
    <dbReference type="EnsemblBacteria" id="EFI33384">
        <property type="protein sequence ID" value="EFI33384"/>
        <property type="gene ID" value="Dthio_PD0715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="590" mass="66036" checksum="04A6982AC30CED64" modified="2010-08-10" version="1">MTNTHLRQKKNVAICGAQSGSVLMYLVAVIVVAGALSAGLVSLTTTSTFTQLSQGNSEQARYMAMAGYEYAKKRLHENAPDIDIDEIADEDEGYSLGDHGSFKLKLGEIDNDLFAGRYEIVSEGIAYKGTSRQASYKIKGKFSPGFIDVPYAEMSEKEIENFIHHSAVKVPDDQNRDDWEPDSDPDNRVPDDVKVLRSSVGGSMLFVPVPATNDYNQYIVRAVVRNSEADSEGYAVFFDTELNDENKPDPGYSFNMDPDADELSIREWDDGERADEPETEVDPEKIEDFDYEDFYYIEIRVTGNSRAARATIYDLEDGANYDYTPKNIRNFKNDGPWNLDSDLSLSHSFSFDFDFTSEEQIYAGFKILGDEPVYFHHLEIELIHDDGQIIIIDDEGNRIEEEFSPILELPTDEHENWVELEIKSGVGTQEYDEFDFYAPEGITVESGVEFLSESAQGKVKLEADSGDINIEDGVVFSTTDSAGNDPEEIYIKTCGNVDIQGAQFDARRYIYIEAGGSINARDADLTVSTNSAQLGIDFVLNKECADIETGNIEVENLYMEFLNRDQQAEADPCEAIEGDLRDLSDNFDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRY0</accession>
    <name>D6SRY0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">Dthio_PD0780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870798.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0780"/>
    <dbReference type="EnsemblBacteria" id="EFI33446">
        <property type="protein sequence ID" value="EFI33446"/>
        <property type="gene ID" value="Dthio_PD0780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10435" checksum="8C2FE3B33A84BB16" modified="2010-08-10" version="1">MNLKPLHDRVLVKRLEEEEVTKGGIIIPDTAKEKPIKGEVVAAGPGKTGDDGKNIPMTVKTGDKVLFNKYAGTEVKIDDVEHLVMREDDILAIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRY3</accession>
    <name>D6SRY3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870801.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0783"/>
    <dbReference type="EnsemblBacteria" id="EFI33449">
        <property type="protein sequence ID" value="EFI33449"/>
        <property type="gene ID" value="Dthio_PD0783"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50347ZE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1771779at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="161" mass="18317" checksum="117853D7FD799511" modified="2010-08-10" version="1">MTLTDYTEMAADLQRVVGEKFRQDREILNVPGVSMACRIDEHYFLALESMLLKNLGMWAAVLPSRVLEALIKTGNMLTCPPHREHSLDLRTTWEGLGRFAGIKACFVQADFFDRALKIYAGRIRPLPLGNLYVNADDRPEVEKFFKGKTPPASWLYQEQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRZ5</accession>
    <name>D6SRZ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipid A biosynthesis acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870813.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0795"/>
    <dbReference type="EnsemblBacteria" id="EFI33461">
        <property type="protein sequence ID" value="EFI33461"/>
        <property type="gene ID" value="Dthio_PD0795"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1106624at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="302" mass="34830" checksum="655BF7946D5858A8" modified="2010-08-10" version="1">MTEKKARSWSSRSIASRWQHRFFYAAIRLGGRRLAYFFTYPVVGYYMLFRPDLRRRTRHYLGRRFPERFGLAAFADSFRLSLSFARVLVDRAIVGILGPDSLDVQFDSYEQIQKLLDQGSGLILMNAHVGCWQASMSSLHMLQRPVHLLIKREPGDVDRHYHEHQKEAPPYNIIDPDNLPASAVEIVGALQRGEIVSVMGDRVFGNDRNRLRVPFLGQEAIFPVGAYKIAAATGAPIAVLFSRKTGPRSYALELAGVIHVKPAEDRHLDSLRPYVLQFVQYLEEYVRNNPYQFYNFHDIWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS03</accession>
    <name>D6SS03_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase FabA/FabZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870821.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0803"/>
    <dbReference type="EnsemblBacteria" id="EFI33469">
        <property type="protein sequence ID" value="EFI33469"/>
        <property type="gene ID" value="Dthio_PD0803"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033N9G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="134" mass="14840" checksum="200A92A0FC46CFBD" modified="2010-08-10" version="1">MNAVRKVVLSARYHSPEVVDNRTVRQYFCFSADFVGFSGHFPGDPVLPAVVQICMGVVLAEDLCPPGQKNNMLLEKVKRAKFLRKLTPEQMIMAECKADGQDLLSFGVQLTVNGETASSFTLEFSLSQKDRPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS62</accession>
    <name>D6SS62_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="10" type="ORF">Dthio_PD0862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870878.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0862"/>
    <dbReference type="EnsemblBacteria" id="EFI33528">
        <property type="protein sequence ID" value="EFI33528"/>
        <property type="gene ID" value="Dthio_PD0862"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="9">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="160" mass="17998" checksum="1BB6A24D662DF4B0" modified="2010-08-10" version="1">MQLILRADVDNLGRLGDVVRVKPGYARNYLIPQRLAYPATKANLNIFEQERKRLQEKMDAIRREAQSLGEKLEEANVVMPVRVGEHDKLYGSVTTAMIADALAQQGIDIDKRKIVLDNPIRNLGEYEIGVKLHHDIQANVKVSVVRHDSEQVTGQSGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSD7</accession>
    <name>D6SSD7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0938"/>
    <dbReference type="EnsemblBacteria" id="EFI33603">
        <property type="protein sequence ID" value="EFI33603"/>
        <property type="gene ID" value="Dthio_PD0938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="161" mass="18523" checksum="E8FE0E06954BCC2C" modified="2010-08-10" version="1">MFKHTAFWIFFTIVGIWGQFFLPGTDFFSPGLVVLLQFGFINTAFWLGCLWMLLLEGTGNLAFGTVILYYAGLIMTYSLASMFFEARNVLFMAFLFLFLAVFKKGLVLVMAGMQDLGQPVHMDAESVLVQFAVHFILWMLIYNLFNKYIMHELVRRKKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSE7</accession>
    <name>D6SSE7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="13" type="ORF">Dthio_PD0948</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870963.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0948"/>
    <dbReference type="EnsemblBacteria" id="EFI33613">
        <property type="protein sequence ID" value="EFI33613"/>
        <property type="gene ID" value="Dthio_PD0948"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="11">
        <location>
            <begin position="302"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="240"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="563" mass="63094" checksum="3A09CF17E4E5DE63" modified="2010-08-10" version="1">MKTKFIFITGGVLSSLGKGLAAASIAALLKARGLKVTLQKLDPYINVDPGTMNPFQHGEVYVTEDGAETDLDLGHYERYLDQPMSQLNNFTSGSIYHSVITKERRGDYLGGTVQVIPHVTDEIKNAILSVATDDEDVAIIEIGGTVGDIESLPFLEAIRQLRGDLGKENVLYIHLTLVPYIKAAGEIKTKPTQHSVKELRSIGIQADIILCRCEVDLEQDIKSKIALFCNVDPDAVFTARDVQSIYEVPLMLYDEGLDQKVAILLKLPAKNPGLQAWENLVYRLNHYKSELHIAIVGKYVDLRESYKSLHEALIHAGLENETRVIPRYINSDDLSQESLARQMQGVHGVLVPGGFGTRGIEGKILAIRYARENNIPFFGICLGMQCAVIEYARNVLQLEGADSQEFNPDTPYPVIYLMTEWFDFRNRTTQKRDTGSHKGGTMRLGAYPCVLKTGTKAMQAYNTSEVSERHRHRYEFNMKFAPDFKSHGLILSGLSPDEKLVEIVELKDHPWFLGCQFHPEFKSNPMRAHPLFREFIRAAGQYALPEEKNPDKASGEKSLDKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSE8</accession>
    <name>D6SSE8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-dehydro-3-deoxyphosphooctonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-deoxy-D-manno-octulosonic acid 8-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">KDO-8-phosphate synthase</fullName>
            <shortName evidence="6">KDO 8-P synthase</shortName>
            <shortName evidence="6">KDOPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyoctonate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kdsA</name>
        <name evidence="8" type="ORF">Dthio_PD0949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57693"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="EC" id="2.5.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the KdsA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.55" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0949"/>
    <dbReference type="EnsemblBacteria" id="EFI33614">
        <property type="protein sequence ID" value="EFI33614"/>
        <property type="gene ID" value="Dthio_PD0949"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00357">
        <property type="reaction ID" value="UER00474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008676">
        <property type="term" value="F:3-deoxy-8-phosphooctulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019294">
        <property type="term" value="P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00056">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006269">
        <property type="entry name" value="KDO8P_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21057">
        <property type="entry name" value="PTHR21057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01362">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="273" mass="29330" checksum="DAED7079473CC89E" modified="2010-08-10" version="1">MTNTPDAMKDLFESSRKDLFFILGPCVLESRDMALQTAESLAGMAASLDVNIVFKSSFDKANRSSLDGFRGPGMEKGLEWLQEIKKRTGLPVITDIHAPQQADEAAGVADVIQIPALLCRQTDLILAAAATGKIVNIKKGQFMAPWDMAGVVDKAASRNPGIWLTERGTTFGYNNLVVDFKSIAIMSGLGFPVILDATHSVQLPGGLKTASGGQREFVPVLARAGVAAGAHGIFMEVHPRPEMALCDGPNSWPIDETFSLLQNLLKIRDALHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSE9</accession>
    <name>D6SSE9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC</fullName>
            <ecNumber evidence="5">3.1.3.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KDO 8-P phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11500"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="EC" id="3.1.3.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KdsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.45" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870965.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0950"/>
    <dbReference type="EnsemblBacteria" id="EFI33615">
        <property type="protein sequence ID" value="EFI33615"/>
        <property type="gene ID" value="Dthio_PD0950"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232828at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019143">
        <property type="term" value="F:3-deoxy-manno-octulosonate-8-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="19623" checksum="1EEC333D85881953" modified="2010-08-10" version="1">MHNHPAQAAQKVKLLVLDADGVLTDGGLYYDPDGRIIKRFNVQDGLGLKLAMAAGLEVAVITGLNSGAVETRVKELGINDYFSGSTHKMPFIRQLSREKNLLFSQMAYLGDDWVDAGPMQCVGLPMAVANAQPEIRKLAAWTSTQRGGHGAVRQAVRFILQAQGRLEQEWRKWVQKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSF7</accession>
    <name>D6SSF7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system fructose subfamily IIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870973.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0958"/>
    <dbReference type="EnsemblBacteria" id="EFI33623">
        <property type="protein sequence ID" value="EFI33623"/>
        <property type="gene ID" value="Dthio_PD0958"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2008912at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00006">
        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="141" mass="14617" checksum="2FA1CC3017845ADE" modified="2010-08-10" version="1">MIGIILVTHGDFGSGLLHAAQTMVGESGNCCAIGVDVSRPMQDIIDQLKQKVKEIDTGSGVVILTDMFGGTPTNISLSLLSHGHIEVITGVNLPMLLKALSGRTQELGDLAQEIKSAGKQGILVAGDVLKRQVAGSGKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSH5</accession>
    <name>D6SSH5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KaiB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870990.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0976"/>
    <dbReference type="EnsemblBacteria" id="EFI33641">
        <property type="protein sequence ID" value="EFI33641"/>
        <property type="gene ID" value="Dthio_PD0976"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1999883at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02978">
        <property type="entry name" value="KaiB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039022">
        <property type="entry name" value="KaiB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011649">
        <property type="entry name" value="KaiB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41709">
        <property type="entry name" value="PTHR41709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07689">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01248">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12585" checksum="80B8BFF15243747E" modified="2010-08-10" version="1">MGSTKNRSTAEKFQQILDQGPQETYLLRLYVAGTSPASARAIKNIRRICEEHLPGRYHLEVIDLYQQPELKLPECVVTAPTLIKELPPPLRCIIGDMSNTSRVLAGLDIKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSL1</accession>
    <name>D6SSL1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="11">ATP-PFK</shortName>
            <shortName evidence="11">Phosphofructokinase</shortName>
            <ecNumber evidence="11">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pfkA</name>
        <name evidence="13" type="ORF">Dthio_PD1013</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871026.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1013"/>
    <dbReference type="EnsemblBacteria" id="EFI33677">
        <property type="protein sequence ID" value="EFI33677"/>
        <property type="gene ID" value="Dthio_PD1013"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01981">
        <property type="entry name" value="Phosphofructokinase_II_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012004">
        <property type="entry name" value="PyroP-dep_PFK_TP0108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000534">
        <property type="entry name" value="PPi_PFK_TP0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="12">
        <location>
            <begin position="72"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="351"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="11">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="437" mass="47665" checksum="3886EFF9DF8F7F00" modified="2010-08-10" version="1">MSSSYDTRIETIGPSKVTSPLPLWRYIEDRETVPMNLDPEMIGEEPNGPIPLEIEVAGPRSNLFFDPSKTKCAIVTCGGLCPGINDVIRAIVMEAHHNYKVPSVLGIRFGLQGFIPSYGHPVEELTPDSVSHIHEFGGTILSSSRGPQPPEDIVDAMERMNISILFMIGGDGTMKAAQAIQQEVARRGNKMSIIGVPKTIDNDVHFVSKTFGFDTAVEKATEAIGCAHAEALGAPNGIGMVKLMGRESGFIAAQATIALKEVNFVLIPESRFDLHGSNGFLRHLEKRLDKRGHAVIVVAEGAGQELFDRKGADPSGNIILGDICSLLRKEILDHFHKKAQEITLKFIDPSYIIRSVPANSNDRVYCGFLGQHAVHAGMAGKTSMVVSMIQDRYIYLPLSLVTQKRKTLNINSNYWGSVLASTGQPSSMENPEKNDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSM2</accession>
    <name>D6SSM2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polysulphide reductase NrfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871037.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1027"/>
    <dbReference type="EnsemblBacteria" id="EFI33688">
        <property type="protein sequence ID" value="EFI33688"/>
        <property type="gene ID" value="Dthio_PD1027"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="372" mass="40483" checksum="23E65594716ADBF7" modified="2010-08-10" version="1">MSKAWFGLLGIGLLIGLFTALTVVVRGLGVYNLNDVTFWALPMAGYLFFALTAAGLTLLSSLPSIFGLKEYYPFAKRAALLAFATLLVGIMCKGLDLGPMSTLLNTVWIGLSPNPASPIWWMAVLYGFYLAFVLIKFYFINKGEWHTTRSWTGGLLALGLMIMAYTALSIVFGTADARPAFFGHFTALYFAVTALTSGMAAIVLASFVHSAIRGSMSQQEETAFDKVAKIFAVMLAIALFVFILRAIIGYTSLQVEFQGFRYIAGTGIYQMELWLGLIIPLILMVVPAIRKTAAGKVVASVLALVGMFAGRLVMLLSAQVMPIGAMAETRPEIVTYTPSFFEWGTIILALSLCLMIYSLGVKYLNLEATPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSN8</accession>
    <name>D6SSN8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871053.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1043"/>
    <dbReference type="EnsemblBacteria" id="EFI33704">
        <property type="protein sequence ID" value="EFI33704"/>
        <property type="gene ID" value="Dthio_PD1043"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1424368at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016041">
        <property type="entry name" value="Ac-CoA_synth_d_su_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03599">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="CdhD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="339" mass="36243" checksum="D9E1F480AA17D4C2" modified="2010-08-10" version="1">MSTPAGLVPRVSPRLSLQDRIKAALARLGPGRDHYRMAPGLYALGDPDGQSPVLVTCNYKLTFDILRRELAGLSCWLLVVETYGINVWCAAGKQSFNAGEVARQVKNAGLEQVVNHRTLVLPQLAAPGVAGHKIRGLCGFKALFGPVEIRDLPYYLDNKMQAADDLRRIKFPLGQRLLVALVEVYGARRFMLWALLACMLLAALGPGGFSLQGTALSGLGAWAVVWTGFIGGVFLVPVFLRQLYFRAFAAKGLLAGALTGFVLAVAVPGGFLQGLAATAACMAFTSWFAMHYTGSTTFTSLSGVDREMRRYMPVQGALILVAVGLWLGSGWLGPLAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSX3</accession>
    <name>D6SSX3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871138.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1128"/>
    <dbReference type="EnsemblBacteria" id="EFI33789">
        <property type="protein sequence ID" value="EFI33789"/>
        <property type="gene ID" value="Dthio_PD1128"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="200" mass="23170" checksum="6A89D102B7D5243C" modified="2010-08-10" version="1">MGMAQPRHEQEFFTYRDYLHWPPDKRLEIIYGTVYDMTPAPLIIHQQILLGLARQIDEVLEDSSCRVLPAPVDVLLPRGLEADEETDTVVQPDLVIVCDPDKIREKNIRGAPEWIIEIVSPSTAGHDQIRKRELYEKSGVSEYWIVHPTDGLVMVYRLEDNAYGKPEVMELKDTTRCMAVPEVSVDWDRVMRRLREAENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST11</accession>
    <name>D6ST11_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">Dthio_PD1166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871176.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1166"/>
    <dbReference type="EnsemblBacteria" id="EFI33827">
        <property type="protein sequence ID" value="EFI33827"/>
        <property type="gene ID" value="Dthio_PD1166"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="430"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="551" mass="62244" checksum="5B1C0C3D322984C7" modified="2010-08-10" version="1">MFAREYVEKHLREVVHELGLKWPDKASIETPREKSFGDLACNLAMLLAGQAGEKPRDLAARFKDMMLGRAEKLQSIEIAGPGFLNFTFKPSFWQSIIPVIQKEQEGFGSSDLGRKHKIQVEYVSANPTGPLHIGHGRGAALGDSLARILRFAGFEASTEYYLNDAGRQMYVLGDSVLIRYEQLCGLEAELSPDHYQGEYLQDDARALYQEHGRDLLKQDRESAIALCREKAVQSILAGIKEDLEHFGVEHQVWFSEQGLFDRGEVQKTLEWLQEKDMAYIHDGALWFRSTSFGDDKDRVLQKSDGALTYFASDIAYHHNKFNRGFETVVDIWGADHHGYAPRMQAAVQALGRPAGSLRVILVQLVNLLRAGQQVSMSTRSGEFVTLRQVMEEVGVDACRFIFLSRKSDSHLDFDLEEVKKKSMDNPVFYVQYAHARICSVFAKAAERGIDTGPEPQSLLHLLESQEDLDLLKQLEMFPDMVQAAARNLSPHHISFYLRELAGLLHRYYTVHSVLNADSRELIHARMLLLQATARVLSNGLKLLGVHAPEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST58</accession>
    <name>D6ST58_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin (Vitamin B12) biosynthesis CbiG protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1213"/>
    <dbReference type="EnsemblBacteria" id="EFI33874">
        <property type="protein sequence ID" value="EFI33874"/>
        <property type="gene ID" value="Dthio_PD1213"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_N" evidence="2">
        <location>
            <begin position="54"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="223"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="344" mass="37465" checksum="ED4655DEADA5E772" modified="2010-08-10" version="1">MQPRNFMAIWAVTSQGANICRKIARQFPGAHIYLGDKVKDPPPEAALFQSLQQAVEEKFGRYRSHVFVMAAGIAVRIIAPHVTSKLSDPAVLVADDSGNFVISLLSGHMGGANTLAHQLSRVLGATPVITTATDNARVPAIDQTARHRNLFMENPQAVKQVSMAFLAKKQVDRFDPGGWLDKEAGAWTNTLAEPLFTRHPGIMVHHDMTPVPEHILVLRPRNLYVGIGCNSATSFEEILEVLHTAFDKNRLSIQSINLLATIREKTGEPGLLQLSKHLQRPLIGITRHILDLVPDVPNPSLMVQRHMGVKSVCEAAAIMAADKGTLMVPKIKSGNVTVAVASCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST59</accession>
    <name>D6ST59_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-3B C17-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1214"/>
    <dbReference type="EnsemblBacteria" id="EFI33875">
        <property type="protein sequence ID" value="EFI33875"/>
        <property type="gene ID" value="Dthio_PD1214"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="28090" checksum="9F476A5D6915DA4A" modified="2010-08-10" version="1">MYIVGIGPGHVSHMTPAAQQALQEAQAVFGYTTYIDLVRPLVEDKKIVSTGMRQEVDRVRRALQAARQGSVCALVCSGDPGIYALAGLVFEMCRENSIPIGDSKDSLKLEVIPGVPALGAGSALLGSPLMTDFACISLSDLLTPWEAIEKRIQAAAWGDFVIVFYNPRSKKRNWQLETARKLILEHRSPGTPVGLVTSATRQEESVSLCTLDSLDCNHVGMQTTVFIGNSRTFIYGSRMITPRGYHEKYQLEMREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST68</accession>
    <name>D6ST68_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">Dthio_PD1223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871233.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1223"/>
    <dbReference type="EnsemblBacteria" id="EFI33884">
        <property type="protein sequence ID" value="EFI33884"/>
        <property type="gene ID" value="Dthio_PD1223"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI33884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="287" mass="31386" checksum="5339AD008E01D748" modified="2010-08-10" version="1">MTLFVAALLGVIQGIFMFLPVSSTAHLVLAQHWLIRHDHPLPPPDSPEMILFDLVVHVGTLVSIVVVFWSSLKVFCVRCVQQSFAWAKKGGRENSILYPRLFLLGMFSVLCTGVLGLSFKAAFEHIFATPYMVGVTLILTGALLWWTDRLKPRRRGLKKINAGVAGVIGLAQGMALMPGLSRSAMTIVFALFTGLKRRWAAEYSFFLAIPTICAATLLQGVEVFRLGGLGEVSPAALIMGFVVAALVGIVSLKLVVYFLYKARLKVFSFYVWLLAAAILSGLLDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST99</accession>
    <name>D6ST99_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Epoxyqueuosine reductase QueH</fullName>
            <ecNumber evidence="5 12">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Queuosine biosynthesis protein QueH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">queH</name>
        <name evidence="13" type="ORF">Dthio_PD1254</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the QueH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="5 12"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871264.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1254"/>
    <dbReference type="EnsemblBacteria" id="EFI33915">
        <property type="protein sequence ID" value="EFI33915"/>
        <property type="gene ID" value="Dthio_PD1254"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1078220at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02089">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003828">
        <property type="entry name" value="QueH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36701">
        <property type="entry name" value="PTHR36701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02677">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="184" mass="21586" checksum="8B0993CA418260E4" modified="2010-08-10" version="1">MPSRVLLHICCGPCSVFPVTSLLEQGHEVMGFFYNPNIQPLQEYLLRREAAEQAAGELGIRMIFQDQDVDPRVFLRQVAFREDRRCFLCHQMRLERTLSAARRGGFNFFSTTLMFSRMQPFEQILALGRTLETEKCRFLDQDFRPGWQQGTEKSRAMGLYRQNYCGCIYSEFERFKSSLPQNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6STA2</accession>
    <name>D6STA2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase, FliI/YscN family</fullName>
            <ecNumber evidence="7">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871267.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1257"/>
    <dbReference type="EnsemblBacteria" id="EFI33918">
        <property type="protein sequence ID" value="EFI33918"/>
        <property type="gene ID" value="Dthio_PD1257"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="160"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="471" mass="50910" checksum="767D8D1CAFFD2BFA" modified="2010-08-10" version="1">MSLDAGACLDLVRDMNPVMTYGKVTKVVGLVVEGRGLKAPLGAICQLLPDEAHEDSAINAEVVGFRDGAVLFMPYGDMRGIKPGSLIRNSSMPPLFPVGSKYLGKAVDAFGTPLEDDGSIIPQKYYPLYAAPLNPMQRPRIDEPLDVGIKSINSLLTLGKGQRVGIMAGSGVGKSTAMGMMARYTEADVNVIALVGERGREVLEFIDKDLGPEGMARSVLVVATSDQGPLIRMRAAYAATAMAEYFRDQGKDVLLMMDSVTRFAMAAREVGLAAGEPPTTRGYTPTVFSHLPKLLERTGKSGKGSITGIYTVLVEGDDFNEPVADAVRSILDGHIVLTRELADQGHFPAIDVLKSVSRLRKDVTPEDVVKAGQKVIRLLAAYEKVEDMINIGAYVKGSNQEIDQAVRLVRPINDFLRQDIEEKFTLQQSFQQMQALLHLDESGPGSQAQESAQTRKTTQGGSKKKQAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STB3</accession>
    <name>D6STB3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1268"/>
    <dbReference type="EnsemblBacteria" id="EFI33929">
        <property type="protein sequence ID" value="EFI33929"/>
        <property type="gene ID" value="Dthio_PD1268"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="219" mass="26109" checksum="BAFCC05447D2EFDB" modified="2010-08-10" version="1">MEYLPLEGWKPTKVSDLVDLPSDDFTIFIPDFNFLLYDAVNDDLEDYDFDETLKALFTLWRYSGSPEFMQGVQKAFQLIKKVDPKARLLDFVQMILHYLEVTRDEKEYIDIKKIAETEIDEGEEYMGTIAEMFRREGDERTEQRFLQEKPIWEKQSELKTTQEMLVKSLKMRFDLVKPNIKEQIRFIQDVDTLNDLFEMSFKCSSIEEFTDLLEKVTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6STG6</accession>
    <name>D6STG6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871331.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1321"/>
    <dbReference type="EnsemblBacteria" id="EFI33982">
        <property type="protein sequence ID" value="EFI33982"/>
        <property type="gene ID" value="Dthio_PD1321"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1000643at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="367" mass="39920" checksum="B3C8B24D4BAA1269" modified="2010-08-10" version="1">MSKVYFWNLRASRKMPYDLRLKKLLKKIDLGSMLEPGMLTAVKIHFGEGGTTGFVSPLWVRPVVEFIKKTGARPFLTDTNTLYVGNRGEAVSHHMQAAMHGFDPNVLGAPVIIADGLRSNNQRRVSFEGRHLSEFYLAGDIMDADFMVNVSHFKGHELSGFGGALKNLAMGCATRQGKMHQHSGLAPKVDDSHCQGCGLCMQVCASGALTLVDEKVRMDPEKCVGCAACILVCKTGALQINWETEGNAFLERMMEYSAAVLSRKKDRCVHINYIFNVTPDCDCPGFSDAPLCPDLGVLASLDPVALDRACLDLVNQAQPLHPSALPKDITPGQDKFTAAHPKTNGSHALDYAHDLGLGSQSYELAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6STI7</accession>
    <name>D6STI7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="5" type="ORF">Dthio_PD1342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871352.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1342"/>
    <dbReference type="EnsemblBacteria" id="EFI34003">
        <property type="protein sequence ID" value="EFI34003"/>
        <property type="gene ID" value="Dthio_PD1342"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="4">
        <location>
            <begin position="98"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="20040" checksum="1150108421543EE1" modified="2010-08-10" version="1">MSAKDLLTCGKVVKPHGLKGEICIIWYADSPLLLKKAEKIYLRMPGKRPRAFTPESSREHGSRLLLQLEQITGRDQAEKWRGAEILADSKDLPRDDDNEIYLHELLGCSVFLDSGEYLGVLQGFVPRKNGEVWEIVDEKGREILFPAEDEFIVHLDPEAKKAVISPPGGLLELYLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6STK6</accession>
    <name>D6STK6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871371.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1361"/>
    <dbReference type="EnsemblBacteria" id="EFI34022">
        <property type="protein sequence ID" value="EFI34022"/>
        <property type="gene ID" value="Dthio_PD1361"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1626243at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="249" mass="29930" checksum="914CBCED7E7AE25A" modified="2010-08-10" version="1">MIISYKHKYIFIHCRKTAGSSIKCFLNKYIGPKDIQIGSWHEVIHNQGSFNRRFIVDLLAPRLFFNISTWKNIKKGLCNKNIYKQLNSIHKKYYNLYHPSASDLAKFDESAWNNFFKFCFVRNPYEKAVSDYIWRVKAKNLDISFLDFLKHLESPNLYKDDHIVPTQIDNWPMYTINDKIAVDFIGKYENLYHDFEQICKIIGLPFYKSQFPRVKHYADYKYREYYGATEKRLVSKIYEKEIECFGYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STS3</accession>
    <name>D6STS3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1429"/>
    <dbReference type="EnsemblBacteria" id="EFI34089">
        <property type="protein sequence ID" value="EFI34089"/>
        <property type="gene ID" value="Dthio_PD1429"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="60"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="251" mass="28658" checksum="49F2407C7D08CA1A" modified="2010-08-10" version="1">MEKKHKDMTKTVISQADFSRYARQYENLLRYKPSYHEVLQQALGAITRRLAPDGEHRIGDFGAGTGSLTRMLAGAFPKSTIQAVDFNASFVCMLEQEAKEFRNIQVIQGDVEKKSFPDNHFDAIAMIHVLRLTDNAHKGLAIQSAYDQLKQGGYLVIADIGRKLNQKRHGWEILQTARREIGFLGTAYLFLRTLNAIRFNVKCSRLERTRPENMLHTLDEFCKKIESVGFTILEARDDLYLGDDDFVVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STY9</accession>
    <name>D6STY9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IstB domain protein ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0053</name>
        <name evidence="3" type="ORF">Dthio_PD1497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871504.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0053"/>
    <dbReference type="EnsemblBacteria" id="EFI32763">
        <property type="protein sequence ID" value="EFI32763"/>
        <property type="gene ID" value="Dthio_PD0053"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34155">
        <property type="protein sequence ID" value="EFI34155"/>
        <property type="gene ID" value="Dthio_PD1497"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="104"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="253" mass="29037" checksum="1B026849B0AADBE4" modified="2010-08-10" version="1">MTNKHQSEVHRLEENLQLLKLTCIKEQYRPAADKAARQNWDHLGYLARLVQAEADARHDRSIQRRIRMARFPGIKTMENFDWTWPTKINRPAIQNLFRLGFMKDKANIIILGGVGLGKSHIATALGYSACLEKHSVLFATTIDVINTLSAAQAAHKLKIELKKYVSPELLILDELGYLPIDKQGADLLFQVISQRYEQKSTILTTNRAFKKWPEVFNNDSTLTSAMLDRLLHHAETILIEGKSYRMKDQVQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STZ7</accession>
    <name>D6STZ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871510.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34163">
        <property type="protein sequence ID" value="EFI34163"/>
        <property type="gene ID" value="Dthio_PD1506"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1986825at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10258" checksum="E2547E8447501721" modified="2010-08-10" version="1">MEYTIPIPDDVAKKVQDRWEDIPGRVLESFALAAYNDGIITEYEIQKILNISSRWELEEFLKKNKVYLYYTEEDLEQDIKNLEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU07</accession>
    <name>D6SU07_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0413"/>
    <dbReference type="EnsemblBacteria" id="EFI33098">
        <property type="protein sequence ID" value="EFI33098"/>
        <property type="gene ID" value="Dthio_PD0413"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="134" mass="15241" checksum="F39F762391BBA4EE" modified="2010-08-10" version="1">MSRYILDTDICIYWLKGSEQLKKKIQQVGPEKLGVAIFSLAELLYGAYHSQRVEQNIMDIQRFTSKIKVFGFDDDAANFFGKIKAGLRKKGQIIEDLDILIASTVLSHGAVLVTNNTSHFARINGLRHENWLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU15</accession>
    <name>D6SU15_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871798.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0421"/>
    <dbReference type="EnsemblBacteria" id="EFI33106">
        <property type="protein sequence ID" value="EFI33106"/>
        <property type="gene ID" value="Dthio_PD0421"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1996277at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8413" checksum="B142C61EDDA68542" modified="2010-08-10" version="1">MNKTRLAYFEEDDVLHLVVSDDEEAGSVEVSPNITTELNNRGELIGIEILGASTFIRDSVLESVHAKILDLAKAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU47</accession>
    <name>D6SU47_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoenolpyruvate mutase</fullName>
            <ecNumber evidence="2">5.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.9" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871523.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0134"/>
    <dbReference type="EnsemblBacteria" id="EFI32827">
        <property type="protein sequence ID" value="EFI32827"/>
        <property type="gene ID" value="Dthio_PD0134"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="405831at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050188">
        <property type="term" value="F:phosphoenolpyruvate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012698">
        <property type="entry name" value="PEnolPyrv_PMutase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02320">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="433" mass="48658" checksum="73B0F2A72C6F1911" modified="2010-08-10" version="1">MKKQVYVGMSADLVHPGHLNIIKKASELGEVIIGLLTDEAIAGYKRLPHMTFEQRREVVENIKGVSRVVPQYTLDYVPNLEKLRPDFVVHGDDWREGVQKETRQRVIDKLARWGGQLIEVPYTQGISSTQLRTTLKEIGTTPQVRLRTLRRLINAKPIVRVMEVHSGLTGLIVEHVHLNGGRGIREFDAMWGSSLTDSTSKGKPDIEAVDVTSRMGTLNEVLEVTTKPIVYDADTGGKPEHFVFTVKTLERLGISAAIIEDKNGLKKNSLFGTEVVQTQEDIDEFCHKIQMGRNARATDDFMVIARIESLILDKGQEDALTRARAYMDAGVDGIMIHSRRKTPDEVFSFCREYNKMPNRKPLVVVPSSFNTVTEQELMDHGVDMVIYGNQLLRSAYPAMVQTAKLILENQRSAEADNQMMPIKEILELIPGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU63</accession>
    <name>D6SU63_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871539.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0150"/>
    <dbReference type="EnsemblBacteria" id="EFI32843">
        <property type="protein sequence ID" value="EFI32843"/>
        <property type="gene ID" value="Dthio_PD0150"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4938">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014592">
        <property type="entry name" value="P-loop_UCP034888"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034888">
        <property type="entry name" value="P-loop_UCP034888"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="199"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="346" mass="38161" checksum="7FD7B5154818EED4" modified="2010-08-10" version="1">MLTRINVNGFKCLEDCELTLAPLTLLTGPNASGKSTVLQAMLLAFSGLEQKNVSYIKEIVKPFSQFEEVACRYSNAHEVRVHIQAENGLYTAVLDRSGFHVTPALDAEPFGYEENLFYLSAGRSGPEELSELNRDLCVGQHGQFALGLLERRKDKPVHPSLIHPEAHANTLKAQLAWWLSFVIGVQTDAKTEKVTATTVKTTFHSEGVENVSPLNTGAGTSFLLKLLIMCLTAKPGDLLLVENPEIHLHPGAQSRLGSLLAFLTARGVQIVVETHCEHLINRVRYEIYTRQLPAGNAAIHYKPGVREPFEAIFINGQGHFCDMEGKERPFPPGFFDSTLAELLVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUI6</accession>
    <name>D6SUI6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">Dthio_PD0280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871659.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0280"/>
    <dbReference type="EnsemblBacteria" id="EFI32966">
        <property type="protein sequence ID" value="EFI32966"/>
        <property type="gene ID" value="Dthio_PD0280"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="207"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="21"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="412" mass="44462" checksum="28786C369747276A" modified="2010-08-10" version="1">MEYQEIQMDGNARIKVVGVGGGGSNAVNNMICSAMKGVTFIVANTDLQALKHSQAEYKVQLGENLTKGLGAGADPQVGKEAAEESIDHIREVLDGCDMVFVTAGMGGGTGTGAAPVIARVAKEMGALTVAVVTKPFYFEGKRRRGQGESGISELKDVVDSIITIPNDRLLSLASKKASFLEMLKKADEVLYYGVKGISDLIMVPGLINLDFADVKAVMSEMGLAMMGTGIATGEGRAREAAMKAITSPLLEDVSIDGAKGVLMNVTCGMDLAIDEVSEAAEIIHESADEDAQIYFGTVFDENIEDEIRITVIATGIEDEHSSSERTSSKVTDLSKVQKGQNNARQRPRNMSVDPDGKDNLNIPAYIRRSRNNQDQAPIESVKQNKTRQKKGEEFIFDEDEFEIPSFIRRQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUK3</accession>
    <name>D6SUK3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hmc operon protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871676.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0297"/>
    <dbReference type="EnsemblBacteria" id="EFI32983">
        <property type="protein sequence ID" value="EFI32983"/>
        <property type="gene ID" value="Dthio_PD0297"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2094424at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="41" mass="4961" checksum="13BE1A87B8C3DB5C" modified="2010-08-10" version="1">MEFYTMLEFDIFTKNWAYIFMGVAVVTMLGWWLFLTGKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUK6</accession>
    <name>D6SUK6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871679.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0300"/>
    <dbReference type="EnsemblBacteria" id="EFI32986">
        <property type="protein sequence ID" value="EFI32986"/>
        <property type="gene ID" value="Dthio_PD0300"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="302" mass="33846" checksum="4C02990D322A4A96" modified="2010-08-10" version="1">MEFRKLQAFVRVYELQSFSLAARDLFLSQPTISTHIISLEQDLRVSLFDRIGRKVIPTQAGEILYQAVQDMFRILDEARSNIQELTSQVSGMVIMGGSTIPANYLLPGVLSSFRRIYSDVCVDLRTADSIKISHDVLEGRLDFGLVGGYAEHLDLENHLLFTDELMVVAAPDIASKYPQVITPQQLPDLPWVMREKGSGTRQAMEEALHKHKMDISSLPAKALVQSTEAMVRCVLSGLGAGVTSRLAVDEFLSSGQLARLEVSDLNIRRRFYLIKHRRRTLYLCASMLMQHILSQLSHNAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUS3</accession>
    <name>D6SUS3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver modulated serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0367"/>
    <dbReference type="EnsemblBacteria" id="EFI33053">
        <property type="protein sequence ID" value="EFI33053"/>
        <property type="gene ID" value="Dthio_PD0367"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="381" mass="42610" checksum="A083E3CBBDEF3352" modified="2010-08-10" version="1">MQYMMQKKYKILVVDDSPLNIRILSSILKDDYRVQTALHGDKALQIIFGDDPPDLILLDIMMPGIDGYEVCRRIKADPGTAGIPVIFVTGRSDVEDEAYGLSLGAVDYITKPFHFPIIKARVKNHLELLQAKRSAQEAHSRLSKELQAMSDLQTSILPSTEYHSQGLYARGFYQPSGLAGGDYFDYLPLGHDGLRCVIADVSGHGARAAFLMSMVRTVFHFDEAVLPLPHLLEALNSQLMQTVGDMGDFVTLMAVDIDPLKNRLEYINAGHCPAFLRDGQSLHEIEPTAALLGFHQEKYKSRFLECGRDWELFMYTDGFYECRVNGKDIFGYEAFRELCFGLLSRDDFQVQDLAGRVSAASKGVVGFEDDLTGIYVQSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUZ4</accession>
    <name>D6SUZ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0039"/>
    <dbReference type="EnsemblBacteria" id="EFI32750">
        <property type="protein sequence ID" value="EFI32750"/>
        <property type="gene ID" value="Dthio_PD0039"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="9"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="347" mass="40552" checksum="64A325BBB3E1DEC6" modified="2010-08-10" version="1">MSTKRNQAPHEGLFLKIFQNLDNARHFLKKHMSEELQKRFDLDTLRLEPTTYVDEKLKKHYSDLVFSVRLVGYKNQFAKIYLLFEHKSSPDPLTGVQVLKYMALQWLDLQEQHMLVDGKLPPIIPIVIYQGQEDDRNMCSSFHYLVEMPSESFKVYIPDFSFAFFNVRGMDEAKVQEKILLKFYVEIIKYQNDPSVKEIPPRLVRGLIESLGHRTALEYIDIFFRYLVKSTGYLTQEDYKKALELLPEGGETIMETLADQWKQQGREEAREAILLEKPIWEERAEIKATQEILIDVAGDCHGPLPNSLQNKIKSINSIDNLRTLTRKVYKTQSLDEFTELVNRAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJQ2</accession>
    <name>D6SJQ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-dependent Lon protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869230.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3557"/>
    <dbReference type="EnsemblBacteria" id="EFI36105">
        <property type="protein sequence ID" value="EFI36105"/>
        <property type="gene ID" value="Dthio_PD3557"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4930">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="92512at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013473">
        <property type="entry name" value="BrxL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014061">
        <property type="entry name" value="BrxL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13337">
        <property type="entry name" value="Lon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02653">
        <property type="entry name" value="Lon_rel_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02688">
        <property type="entry name" value="TIGR02688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="1">
        <location>
            <begin position="522"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="681" mass="76281" checksum="236D0193F0E66C4E" modified="2010-08-10" version="1">MELDYLDKKASQVLDGYLVRKDLVRTFSRQFPVPTYVVEFLLGRYCASVEWEEIEEGLEIVQKQLKSRTVKAGEEELFKARAKEAGQVKIIDSITARLDARTDSYITALPSLRLTDVRIDPELVIKNERMLTGGFYAEITLSYDPYIAQEKNGRPFGVEALREIQLSQRDVLDHLAEARKHFSTEEWKDFLLRSIGLEASTLSPRQKNAFMLRMVPFVERNYNMVELGPRGTGKSHLFQQVSPYAHLISGGKATVARMFVHMGTGQRGLVCQYDVVCFDEISGISFDQKDGVNIMKGYMESGEFSRGRDSIRADGSIVMVGNFEVDVEHQQRIGHLFGPMPQEMRDDTAFMDRLHAYLPGWDIPKISKKYLTDHFGLVSDFLSECWSRLRDESRVNLLQNRVFFGGALSGRDSNAVNKTISGLLKLLYPQDPLEIPDEELEWATQIALESRRRIKEQQKRIGAAEYRNTHFSYTIGTDGVEKFVSTPELHSENSIGADPLEPGQVWAISPGIENENPGLYRVEVNSGPGSGIKILNKPVPPAFKESMGYAEQNLYSRAAQLVGDKDPRSHEYTVQLRAFDAARSGAKLGVPALIALCTSLVRKSVRGGLVICGEINLGGSIEPIHNAVSMAEIAVEKGAVALLMPVSCRRQLIDLSDDMATKIDIQFYSDARDAFMKAIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJR4</accession>
    <name>D6SJR4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869242.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3569"/>
    <dbReference type="EnsemblBacteria" id="EFI36117">
        <property type="protein sequence ID" value="EFI36117"/>
        <property type="gene ID" value="Dthio_PD3569"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10619" checksum="4C91976C0CDAF841" modified="2010-08-10" version="1">MNIVSFKHKGLKKLYENDDPSGLPNQHVVKIKNILAALEFAGDLSQVASVPGWKLHPLKGDRKGEYAITVTGNMRITFYLKGNNIHLINFEDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJS7</accession>
    <name>D6SJS7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869255.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3583"/>
    <dbReference type="EnsemblBacteria" id="EFI36130">
        <property type="protein sequence ID" value="EFI36130"/>
        <property type="gene ID" value="Dthio_PD3583"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="252" mass="27655" checksum="18D939254A87089E" modified="2010-08-10" version="1">MSKADKQSKGTACTQAKSMFQNVRNTTQLFAVLLSALLLGLGVYYFNILFVLGALLAALFAGRVFCGWICPNGAWIDHGVSRFSRYRKLPGILNHRWFGYGFTFVFLTAFAFVHWNVQGSAWVWLVPIGMMGVQVSLATILGGLYHPRSFCSHICPWGVLGALIGKKGRYQMRIDTSCKSCHTCARQCPLGGILEPAIAQVKDRKEPAQVSTSCMRCMRCVGACPTNALQFGVHEDASKQVKGQEHPAVQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJY9</accession>
    <name>D6SJY9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3648"/>
    <dbReference type="EnsemblBacteria" id="EFI36192">
        <property type="protein sequence ID" value="EFI36192"/>
        <property type="gene ID" value="Dthio_PD3648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="68" mass="8136" checksum="858CD1E0C13DD1B2" modified="2010-08-10" version="1">MKEHREYAQRLINSLDSLTRENEPDRIVSQPPDVQKKRWTCTMSLRSPLKGIKSDVWCCKTHERFFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK00</accession>
    <name>D6SK00_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteinase inhibitor I42, chagasin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3660"/>
    <dbReference type="EnsemblBacteria" id="EFI36203">
        <property type="protein sequence ID" value="EFI36203"/>
        <property type="gene ID" value="Dthio_PD3660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036331">
        <property type="entry name" value="Chagasin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018990">
        <property type="entry name" value="Prot_inh_I42_chagasin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09394">
        <property type="entry name" value="Inhibitor_I42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141066">
        <property type="entry name" value="SSF141066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I42" evidence="1">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="88" mass="10261" checksum="F70C461F51171C25" modified="2010-08-10" version="1">MQKGRDLIQPPPAPPWLRRGVYTVPVIYTEHSFEQIQEAEEMVGSGGMEYYRYRALQEGKTEIKMIYGQHWDGGYKNPAWVFNVKVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK05</accession>
    <name>D6SK05_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3665"/>
    <dbReference type="EnsemblBacteria" id="EFI36208">
        <property type="protein sequence ID" value="EFI36208"/>
        <property type="gene ID" value="Dthio_PD3665"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="902"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1212" mass="135786" checksum="9C554197B10A5139" modified="2010-08-10" version="1">MVRVFMKNCVFSCIIRMLCRTGSGESKVLGALSAAGMLLVFLLFAGTAWAGSGAVDLPRFPSISPDGSRIAFSSGGDLWLAGIQGGEARRLTRHRHDDLHSNWSPDGESLVFTSMRDGYMNLWRIREDGTQVRQLTHSDRFMRNPDWSMDEEGREVITLSGLLEADVYREHRPYRLPPEGGQHERLHQAFGSEPRLSPCGSKTVFTRGGFYHDWNKRHYLGPDAMNIWVHHREEDRFEAITTRDGDDGMARWADEDTLIFMSDRDLGTVNLFRLDLGDEEPEPVRLTDFQERDVKHFDVSADGSTVVLQGWDRLYSLDLEDAEAESEPINLRAGDDGPDRYELRSVDREVTEAALSPDNQVLAQVAYGRVFVRHVDEYSPTRPVTPGTHARHRHPAWSPDGLRLYFTSDAHGTDSIYKARVALTREEIRLGVHDITVDGQPEKSPQKTPPEESEVKPDREEQRLQGQPEKDLREVEDEADDPFAPLDPVDPGAPRGPDPAPEPGTDPAHDPDPEPQEEPEEDLGLEQAEGLPGKMDPARWQDAVHFEVVPVVDSGLNDRRPSPSPDGKRLAFLRGPGDLMVKDLTSGKKQTLVEGWDFSMHWRWSHDGQYIAYSQNDLNFSSNIFIVPADGSEEPVNITRHPRNDLNPRWSADGRILSFISNRSGDNYDVYRVYLDPDMENMTTRELHNYYREAGKEAEKIRPLPVRLPGSPPVPTPLSLEPWEMDLENAWRRIEPVTNSSLNKTSNEMTPGGDRFLFNSGGDDLVSLKWDGSERKRLSSAVNVQGLDITGKSAVYTLRGEAGIAPLDGGEHRRPGISENIRIDKKEQSLQKFREAARVMQEHFYLSDMKGLDWPSLTREYEELVKRTRTASEFSDISNRFMGELGASHTGVFNPGPEAGTREPSGRLGIDYQQVSLEDGGYGFRVKDVVPGGPAHRSAVSLQPGDIITHIDMHRFEEPETLLQRLRGTAGREVVVGFKRPSDDGFLNHNTLAIPVSYEDLAALRYEAFRDESSKKVSNLSDGRLGYIHIQTMNQASLEDFQGHLYAAAKGKEGLIIDVRNNAGGYTTDLILASIMTREHAYTVPAGADPQKTGHYPQDRLPVPRYTLPINMLANEKSYSNSEILAHAFKTLDRGVLVGEQTYGGVISTSGYRLIDGAQVRVPSRGWYLPDGTDMEQNGAVPDLRVEQTPEDEAAGRDPQLEKAVENLLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK21</accession>
    <name>D6SK21_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869346.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36224">
        <property type="protein sequence ID" value="EFI36224"/>
        <property type="gene ID" value="Dthio_PD3681"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2219732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="190" mass="22792" checksum="6386B11971811CF7" modified="2010-08-10" version="1">MKKYLWLTFIPVILFMAGLSQASYRIELESGKSVITRHYWEEDDWVMFYQYDGVVGYPAHLVRDIRESDRLPPDEAMEKAVGGEQREDLETTDVDLIEEADEAKTDMDPEEFERKVEQYQEELRDIYRRLVVKSQEYYSAMRENRPNLKKEARNSHQKLMDQKKQLKQKVIEAYKGEKPDWWDKIISQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKA1</accession>
    <name>D6SKA1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869423.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3768"/>
    <dbReference type="EnsemblBacteria" id="EFI36304">
        <property type="protein sequence ID" value="EFI36304"/>
        <property type="gene ID" value="Dthio_PD3768"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1840229at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10046" checksum="7C18D6CA8DDB24DD" modified="2010-08-10" version="1">MEKVRTNEYWPVYVFPPGDTILETIEAIGMTRDQLAHRMGVPEDHINEVIKGKAVLTEDIVLKLEVVLGIDASFWRNLEHMYRRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKK6</accession>
    <name>D6SKK6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid-binding ACT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868351.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2626"/>
    <dbReference type="EnsemblBacteria" id="EFI35217">
        <property type="protein sequence ID" value="EFI35217"/>
        <property type="gene ID" value="Dthio_PD2626"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1670797at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045739">
        <property type="entry name" value="ACT_dom_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19571">
        <property type="entry name" value="ACT_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="143" mass="15834" checksum="9DCAEAF5D90D31E9" modified="2010-08-10" version="1">MIVEQISIFLENRAGRLADVTRTLAEAGINIRALSLADTTDFGILRLIVTDHEKAKQALKENGFTVGRTNVVAAEVEDRPGGLHAILTMLSENGINVEYMYAFVQQSGQNAVLIFRFDRTEEAVETLQKNGVRIIPGDELYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKP7</accession>
    <name>D6SKP7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868391.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2669"/>
    <dbReference type="EnsemblBacteria" id="EFI35258">
        <property type="protein sequence ID" value="EFI35258"/>
        <property type="gene ID" value="Dthio_PD2669"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1974373at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="192" mass="20935" checksum="5CECBE261F036144" modified="2010-08-10" version="1">MLKKKNEQGFTLLEVAMVLIVASLIVIATLSAQGVWDTAKSFRLERHVQEMRVAVALYENKIGSLPGDGDPNTPGDPDGEIDNGTNFWYEVLNEEDLVTSEQQANRHPFGGDVVLAFSDGATTASTNPFDLDINVFTYENIPVEWAETLDNAIDDGESNSGRVQTTDPGQANAIDDYNSAAGDLVDVWVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKS5</accession>
    <name>D6SKS5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2700"/>
    <dbReference type="EnsemblBacteria" id="EFI35286">
        <property type="protein sequence ID" value="EFI35286"/>
        <property type="gene ID" value="Dthio_PD2700"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2186299at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="261" mass="29562" checksum="7D3ECF2A67B029F9" modified="2010-08-10" version="1">MKQKSYSGFKGPKLAIFLIFAGLAAVFLGLGFLDYRENKHQEVQIDFFPDEEAPDINMQELQDQFVPGQVGDPQDHQIIISNNLFSPERRPWARPVSEDPDDARRVQADPGAFRLHGIISRDDERMALIYNHDLPSPDTYSLVRAGQSITMEDNGLQTAYTLTDIHDDYVTIQSGGRIFHVHLFADRPTREDDPREEPEGPPDALEPLAPGTGLEHLMQRLEDDEVSPDPAPSPEDMERLVEEGRMHRIDTPLGPVYRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKV5</accession>
    <name>D6SKV5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868448.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2731"/>
    <dbReference type="EnsemblBacteria" id="EFI35316">
        <property type="protein sequence ID" value="EFI35316"/>
        <property type="gene ID" value="Dthio_PD2731"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="964385at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="260"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="2">
        <location>
            <begin position="589"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="2">
        <location>
            <begin position="657"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="2">
        <location>
            <begin position="971"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1679" mass="188065" checksum="787ABB8D4B1CA035" modified="2010-08-10" version="1">MIRYFRRTAIFSVVLLFSLICFNWHVGHCGNVYYVSSNDPLASDINPGSAEEPLLTLGEALSRVTAGDTVVLEPGTYRESMLFSQGGESEDFPVTVRAGVPEAAFVLGSDVVVGWEHAFDETWVRHGWEINSQQVFVDGLGLQQIGPGSLYHYLEVDGDTALPVVGSDFSDMYPGSFWYDEDMGSLYVWLPDGSSPENYVMEASVRDFLLAPNSLDYINLEGLVFAHSNTGTSGEEVSMLNISGTGWKLEDNFFLMADMSGLSLSGRDHLLSGNTFLLNGYAGLVLRGHEDQGEERQILMSGNEQSYNNTRNFDFSLKPGGINITDGCSGLTIENNLAWRNHMFGVSMDSQSKDIVLEKSFFQDNILGVYAEETDSIIVKNNIFNENFYAAGLDSTSNTHVLFNTFHANEYAFTAMDSMGDSPLFQNNHIQNNLFSDSLIVDLGLYIPDFLDEGNTSDYNAYARASQEIANIWIDEIGFPVFSFSLSSFQDQSGLDQNSVVSASIWPEEHDFAFVPPHDALIIDAGSLELQAVLSDFYGRERPWGMGPDIGAVEYYPDDEEFPEYPHELAELDPSVPEQPPEPDMWEISVSVTGEGQVKVNPDQTEYMDGSMVELSVHAGDGWYFVQWQGDLSGSETPVTLVVDEDKNISALFERLYTLSISVEGEGSIIRTPDLSEYESGESVELEAVAADGWEFVGWSGDASGTDTSLVLVMDTDTSVTGVFEEIPEPEPEGEVFVFDPNAYETGYNPVGDVFIQRLPGSSDFGGDTGIAEVSTPVGNKVMQFTTELSSPYFHGGVRWLYWTEFQRDQDQIEFLYLFRRSDPEYTELLGCMRMSGEAELNTYAAGLRNNSDEIRGRRVLQGNIINAGEENHNLSGDTVGDWIWVRGRMDQDSYTIRSRAWLHGDNEPENWMLEWTDQDEAIEKGGVGMEVYIRQAGESVELAWLSMGSRGEVAPGPEDIEELPEPTEHYTLDISVEGQGSVSLSPERDQFESGESVELQAVAADGWEFVSWSGDYSGTEPSVVLVMDTDMSVTGIFEEIPEPEPEGEVFVFDPNSYETGYNPVGDVFIQRLPGSSDFGGDTGIAEVSTPVGNKVMQFTTELSSPYFHGGVRWLYWTEFQRDQDQIEFLYLFRRSDPEYTELLGCMRMSGEAELNTYAAGLRNNSDEIRGRRVLQGNIINAGEENHNLSGDTVGDWIWVRGRMDQDSYTIRSRAWLHGDNEPENWMLEWTDQEAGIASGGAGLEVYLRRAGDSIDLAWWSVGFGGAAAEFPEEETYENDEFFPPEIYGHYFDPAWAEAEPGLIRDLGYGNPSEWPVVNGHDTRIVIQDEQSVDLKDIRAAISWDSGPDKYGTTYIHIRNCEEVVVENVHLLQADQDYLASHTLFIEDCGKVILRDSSFHGSVERHHVRMEGNAEVIIDNVEISGYDYGNGIIRTGGGIRIENGDESRGGVGLASISSPNPRELEWLQITNCHIRDNLSNPQRLKHDGILIHSGGNSLIYNNLFENWQELDAAFDTSHRRWQDNNYVNKTIHIEKNRFINNQRIKMPGRSVADNSIVFYKNYFENSGLYDYHIGYNVIFRENLFDGVFDSTMLTLWQINGPMLFERNNFIFEDLHMFIREGGAADPDAHTHVNLRDNIYFLGNVSTWLMGKQVQAYTWEEWQNVGLDTGSEIRPLSEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKW8</accession>
    <name>D6SKW8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868461.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2744"/>
    <dbReference type="EnsemblBacteria" id="EFI35329">
        <property type="protein sequence ID" value="EFI35329"/>
        <property type="gene ID" value="Dthio_PD2744"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="137"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="480" mass="53860" checksum="B071A82BFC97D463" modified="2010-08-10" version="1">MAEILVIDDDLIFNEVMEEQITRLGHDCDTVASLYKGISRAQKGAYDIVFLDVTLPDGNGLSELQAFKNAASAPEIVILTGYGDPEGAEVAIKNGAWDYIQKPASITTIQLTISRALRFRLTKLQSDSSRTVVRHGIIGNSAKIKECMDHIAQAATSSINVLITGDTGTGKEMFAKAIHLNSKRAGKPFIVADCTSIPETLAESLLFGHQKGAFTGASANSLGLFLQADEGTLFLDEIGDLSLPVQKSFLRVLQERKFRPLGAREEKQSKFRLISATNRHLEKMITEGVFRKDLYYRLRAIHIHLPPLRERMEDIPLLLDYYIPKVCEEMDIKTKKYSGEFLNACLEYDWPGNVRELVNAVNNSCSNAINDNELFLYHMPLEIRAHLAKKKVNSTVVHDEAIQSITSNSHAEPVSYTGTDNFPTYKESRRAVVDQMESRYLRELLKHSSRDFKKACNVSGLSRARLYELFKKHSISVKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKX1</accession>
    <name>D6SKX1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2747"/>
    <dbReference type="EnsemblBacteria" id="EFI35332">
        <property type="protein sequence ID" value="EFI35332"/>
        <property type="gene ID" value="Dthio_PD2747"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="418" mass="46924" checksum="4489898D0D957535" modified="2010-08-10" version="1">MDTSNWDWEKGVKVISKINDCDAETEWLTEPYASPDGEKVAVLAKTEEGFDVCVNAKAWGQTFDNAWYPRFSPDGRLTCVASTDMEWTLAVDGEPWPETYGYIWNTMFSEKGDVIAAAIQQDGTYGMAINGEQVGELYETASEFTLSADGKRTAAVVQVQSMDAADIFTFQQGCYSVAVDGQAWDIKVVNAWTPTFSPDGSRVAAQMRSSLYDYTIIVDGTPWSKNFAMVWDPCFNPKTGTVVAPVRMAGKWGMAENEQVIWDPVYFQLWEQKFSPDGNNLYAICAPQYGRWTVVHNNNTWNVLVNTMLTDLTVSPDGQRAAAAAKEKDKWTIMADDALWPQWYDMVWTPVFSPDSKHIATKVEKPGKKLTVAIDGKHYKEDFTHCWEPVFSPDSQKVLIRGVQGGKFKRIVAKVNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL17</accession>
    <name>D6SL17_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868510.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2794"/>
    <dbReference type="EnsemblBacteria" id="EFI35378">
        <property type="protein sequence ID" value="EFI35378"/>
        <property type="gene ID" value="Dthio_PD2794"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="325" mass="35749" checksum="0FBDB8D74A05A577" modified="2010-08-10" version="1">MIELINVTKIFPGAPSPSVDNVSFRVNQGNICVLLGPSGCGKTTILRMMNRLEEPSSGKILINSENTLKSDPSALRRSIGYVIQQTGLLPHRTVARNIALVPGLLGWPQEKINNRVDELLKLMGLDSGDIADKYPHQLSGGQMQRVGVARAMAADPPIMLMDEPFGAVDPIIRIRLQDEFLKLQQQVRKTICFVTHDINEAIKMADYLIIFNQGRLVQMGSPVEVLTSPADDFVLSLIGDDRGVKILDLTRAETLMEPADNISDDLLGSGCTVQSYQPVKLALEVMMKKNQDRVGVCRGNHLAGTLSWSDIKRHINKVSGEESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL64</accession>
    <name>D6SL64_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868557.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2845"/>
    <dbReference type="EnsemblBacteria" id="EFI35425">
        <property type="protein sequence ID" value="EFI35425"/>
        <property type="gene ID" value="Dthio_PD2845"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="107" mass="12312" checksum="9F6DB7AEB9D16A28" modified="2010-08-10" version="1">MANPQELADMFKVLATPARVRILQLLKNECLCVNALARELEITPASVSQHLRVLRDSGLVRGRKHGYYVHYEVDMENLHRWKTSAQLFLTAPLDRMPELKSKISNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL92</accession>
    <name>D6SL92_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2873"/>
    <dbReference type="EnsemblBacteria" id="EFI35453">
        <property type="protein sequence ID" value="EFI35453"/>
        <property type="gene ID" value="Dthio_PD2873"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="192" mass="21901" checksum="443713B563FF1583" modified="2010-08-10" version="1">MQKFPEYVLSQAVMTIKAARMWVLAAFMIYCAAAVVAWSQSEHFDFMEAQFGTLVEQFEGLGAWEFILRIFVHNLIASYLALCFIVFFGAVPLALAALNGFMLGWFINWMDHFSGLDFLIMLGPHGIFELPAMFIAFGVGMWRGVGFRMDQEQPGWVERLKRVHCVFAVFVVPLLFVAAILEGRYHLLELLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL96</accession>
    <name>D6SL96_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868589.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2877"/>
    <dbReference type="EnsemblBacteria" id="EFI35457">
        <property type="protein sequence ID" value="EFI35457"/>
        <property type="gene ID" value="Dthio_PD2877"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="141"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="460" mass="51687" checksum="FB76BD877CF931AB" modified="2010-08-10" version="1">MSGKILIIDDEEDIRLSLRGILEDENYQTLEAESGEQGLGLLGPGVDLVLLDIWLPGMDGLEVLNRLRESHPNLPVVMISGHGNIQTAVQAIKSGAFDFIEKPLSLEKVLITSEKALEFSRLRRENRKLRLSSKSAEVHRITGESDHIEELRQNIEQVAPTEAWVLITGENGTGKEIVARSLHIKSNRADHPLIAVNCAAIPEELIESELFGHEKGSFTGASSCKQGKFELADGGTLFLDEIGDMSLKTQAKILRILQEQSFERVGGHKTINVNVRVIAATNKNLQQEMKKGNFREDLFYRLNVFPLNLPPLRDRKKDIPPLLEEFTSQLSQEHNFKPLSFSPDAISILQKHPWPGNVRELKNFVERMYILHQGKEISASMLPAEIREAALSGQGPDKSAPDIPDAMPHDFKQARSLFEARFLDQKLKEHEGNVSRLAEAIGLERSYLYRKLKNYNISTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLB9</accession>
    <name>D6SLB9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868612.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2902"/>
    <dbReference type="EnsemblBacteria" id="EFI35480">
        <property type="protein sequence ID" value="EFI35480"/>
        <property type="gene ID" value="Dthio_PD2902"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YQJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1948244at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="9610" checksum="A31F7E8736E3313A" modified="2010-08-10" version="1">MTPTVFRKKGYRFFFFSREETRMHVHVVSNEGEAKFWLKPELELANNYRFSRKELKEIEAIIEEHHHELASAWIKHFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLD2</accession>
    <name>D6SLD2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nitrogenase iron protein</fullName>
            <ecNumber evidence="11">1.18.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nitrogenase Fe protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nitrogenase component II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nitrogenase reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nifH</name>
        <name evidence="14" type="ORF">Dthio_PD2916</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate</text>
            <dbReference type="Rhea" id="RHEA:21448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17997"/>
            <dbReference type="ChEBI" id="CHEBI:18276"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.18.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the NifH/BchL/ChlL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.6.1" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868625.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2916"/>
    <dbReference type="EnsemblBacteria" id="EFI35493">
        <property type="protein sequence ID" value="EFI35493"/>
        <property type="gene ID" value="Dthio_PD2916"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018697">
        <property type="term" value="F:carbonyl sulfide nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00533">
        <property type="entry name" value="NifH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030655">
        <property type="entry name" value="NifH/chlL_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000392">
        <property type="entry name" value="NifH/frxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005977">
        <property type="entry name" value="Nitrogenase_Fe_NifH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42864">
        <property type="entry name" value="PTHR42864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00142">
        <property type="entry name" value="Fer4_NifH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000363">
        <property type="entry name" value="Nitrogenase_iron"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01287">
        <property type="entry name" value="nifH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00746">
        <property type="entry name" value="NIFH_FRXC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00692">
        <property type="entry name" value="NIFH_FRXC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51026">
        <property type="entry name" value="NIFH_FRXC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 11 12" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase" evidence="11 12">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605977-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="276" mass="29879" checksum="39E79209195D4E31" modified="2010-08-10" version="1">MRKVAIYGKGGIGKSTTTQNTVAGLVELGKRVMVVGCDPKADSTRLLLGGLSQQTVLDTLREEGEDVELDDVRIGGYGNSLCVESGGPEPGVGCAGRGIITSINLLEQLGAYEEDESLDYVFYDVLGDVVCGGFAMPIREGKAQEIYIVVSGEMMAMYAANNICKGIRKFSETGGVRLGGLICNSRAVDNEEAMIKAFAEKLGSQMIYFVPRDNDVQRAEINRKTVIDFTPQAPQADHYRNLAKAMDSNQMFVVPTPIETEELESLLLEYGILETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLN2</accession>
    <name>D6SLN2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868722.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3021"/>
    <dbReference type="EnsemblBacteria" id="EFI35593">
        <property type="protein sequence ID" value="EFI35593"/>
        <property type="gene ID" value="Dthio_PD3021"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1020023at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="273" mass="29418" checksum="ACD91DC07242C70C" modified="2010-08-10" version="1">MAREIRDIVKIDEELCDGCGLCVPGCEEGAIEIRDGKARLVAEKYCDGLGACLGHCPRGAITVIKREADPFDMEAVEERLREQEAAGQSPQEKPETASRLGCGCPGSVMADFAPDKAHTPAQGTENIQSALTHWPVQIRLVPPHAPFLKGAHLLIAADCVPVAYPGLHQDLLPGRKIMLGCPKFDDGHDYVERLTEIFRQADIKSVTVASMEVPCCAGMVKIVEKAVVQAGKGMAVEEVVISRQGQVMPQGRPGAEQSRQKHVQVQQGSCACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLR0</accession>
    <name>D6SLR0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase assembly chaperone hypC/hupF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868750.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3050"/>
    <dbReference type="EnsemblBacteria" id="EFI35621">
        <property type="protein sequence ID" value="EFI35621"/>
        <property type="gene ID" value="Dthio_PD3050"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2031925at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8320" checksum="3C68529F1999994B" modified="2010-08-10" version="1">MCLAVPMEVVSIEDNVAHVEVGGVKNQVRLDIVDQMPAVGDFVIVHAGFALRCIDRQEGLETLKLFQDSLGLELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLW0</accession>
    <name>D6SLW0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD3100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868800.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3100"/>
    <dbReference type="EnsemblBacteria" id="EFI35671">
        <property type="protein sequence ID" value="EFI35671"/>
        <property type="gene ID" value="Dthio_PD3100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="192"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="392"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="563" mass="61702" checksum="82C1306F26123F65" modified="2010-08-10" version="1">MELTGAQILLECMRQEGVQHIFGFPGGAVIDIYDELPKSSIQHFLVRHEQGAVHAADGYARSTGKVGVCLVTSGPGATNTVTGIATAYMDSIPLVVFTGQVPTALIGNDAFQEVDIVGITRPCTKHNYLIKDVKELAHSIKEAFYIASTGRPGPVLVDLPKDVMQARTEFDYPKTISLRSYNPNYTPNRKQVKKAAGLLAKAERPLIYSGGGVISSEAGEILTRLARRFSVPVTSTMMGLGAFPGNDPLWLGMLGMHGTYAANMAVNNADVLLSVGARFDDRVTGKVNTFAPRAKIIHIDIDPTSIRKNVNVHIPIVSDCLNALKTLDEEMGEINEVQWEEKHASWVKTVKGWNQEQPLKYETVQSGKIKPQYVMEQVYELTKGEAIITTEVGQNQMWAAQFYKYHKPRTWISSGGLGTMGYGFPAAIGAQVANPDKLVIDIAGDGSIQMNIQEMATAVCYNLPVKIIILNNSYLGMVRQWQELFYNKNYCATCLDTAPDFVKLAEAYGAEGYQVDKTEDVVPVLKKVFASPKTCIVDIRVEPEENVYPMVPAGASLTEMLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLZ6</accession>
    <name>D6SLZ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868836.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3136"/>
    <dbReference type="EnsemblBacteria" id="EFI35707">
        <property type="protein sequence ID" value="EFI35707"/>
        <property type="gene ID" value="Dthio_PD3136"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="126"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="282" mass="32361" checksum="0004DA7814B21667" modified="2010-08-10" version="1">MDNPTFKSKQDQEKLVQELLELENLLRKQGGNHNPGETRGRIALVRLLDDLDQEDLEELKLKSRVDPAWLTLALDQEKFPALMEMQKNIENLTRARDRDALTGLYNRGFFQRILDREVERAFRFKLPLTLAMMDIDDFKKINDTCGHPCGDRVLQDLGGIIQQEIRAADYAARIGGEEFALILPGTGRYKSEPLFWRIMDSIRSRQVECPHSRHKVSYTVSIGAATYRGKTEITAERLISEVDRQLYKVKEHGKDSISAEIFQDAVNEEALVQKAEKNFLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM55</accession>
    <name>D6SM55_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868895.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35766">
        <property type="protein sequence ID" value="EFI35766"/>
        <property type="gene ID" value="Dthio_PD3197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1990984at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="88" mass="10039" checksum="21F71913E9F6BAE0" modified="2010-08-10" version="1">MQQLNIKVEIFKEDDIYVALCPSLNVSSFGETIEEAKKSLVEALEIFIEECSEMGTLDQVLEESGFTRDNQTWKPRETVIEERVALAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM72</accession>
    <name>D6SM72_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RelB antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868912.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3218"/>
    <dbReference type="EnsemblBacteria" id="EFI35783">
        <property type="protein sequence ID" value="EFI35783"/>
        <property type="gene ID" value="Dthio_PD3218"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="8855" checksum="1274D525FAFB7903" modified="2010-08-10" version="1">MSSTTTSHNRVDPNIKRDADQIIKDMGITISDAHELFYRQIIANQGLPFFVAYRQINGSWHHLPGWQANVNCIGAIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM86</accession>
    <name>D6SM86_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase (Ubiquinone) 24 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868926.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3232"/>
    <dbReference type="EnsemblBacteria" id="EFI35797">
        <property type="protein sequence ID" value="EFI35797"/>
        <property type="gene ID" value="Dthio_PD3232"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="153" mass="17386" checksum="D07A50111A81E68C" modified="2010-08-10" version="1">MDHVLDKVIENYHENEGNALTLLQDLEENFGYVPEETVYELSDRLNIPPSRFFGIATFFSQLHLKPRGKNIITVCRGTPCHVKGSEKILSRMRMELDIPSGEETSEDRMFTVEEVNCVGACGMAPVVVINQQVQGEVNIKKMMKEVNELRAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMF4</accession>
    <name>D6SMF4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868994.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3304"/>
    <dbReference type="EnsemblBacteria" id="EFI35865">
        <property type="protein sequence ID" value="EFI35865"/>
        <property type="gene ID" value="Dthio_PD3304"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1491554at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="265" mass="30747" checksum="EEA1047EA5766749" modified="2010-08-10" version="1">MSAELNKARKNLTNIPSLMKQDKLLAAVTALQEGLTTFLKGNLMQSEKKEFLEMIDRSLHALNSNQALRQVYPVLLKLEPGKEKELLQNVRELQSALQEEMTSEAKESLAEMEKRKTDTLEKARSLLKEGQQDKADASLRKLVREFTDDFDLKINIADILISAEAYEKALDYLKMAYRDNPRSVHIYNRLGMALRKLGRFEDSEKAYSQALKITPQDEYLHFNMGRLYMDMQQWNKALHSAYKALEINPDFEQARKMLHYSQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMH2</accession>
    <name>D6SMH2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRAP transporter, 4TM/12TM fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869012.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3322"/>
    <dbReference type="EnsemblBacteria" id="EFI35883">
        <property type="protein sequence ID" value="EFI35883"/>
        <property type="gene ID" value="Dthio_PD3322"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271112at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021814">
        <property type="entry name" value="DUF3394"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011853">
        <property type="entry name" value="TRAP_DctM-Dct_fused"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11874">
        <property type="entry name" value="DUF3394"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02123">
        <property type="entry name" value="TRAP_fused"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="3">
        <location>
            <begin position="171"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="751" mass="82175" checksum="CAB34044E63DBF4A" modified="2010-08-10" version="1">MSEQAGKNNTLEENQKTTENQDGQDKAPPTTKEARDLVVMVEAGVRDPKSIVARWIIVLLCLAWSIFQLSIAHDPINSHIARIWHLAFAIGLTFLVYPAYKQHSTPFWVSLTQKIIPSFASKSIRKTIPVYDWIFAALGMASALYLWWDFDNLIFRQGMPNQTDIVMGFILIVLLLEAARRALGPALSILAAIFLAYNFIGPYLPEILRHRGIPLDFMISDMYLTTTGIFGVPLGVSVSFVFLFVLFGALLDRAGGGKYFIDVAFSALGTFRGGPAKAAVLASGMTGMISGSSIANTVTTGTFTIPLMKKVGFPGHKAGAVEVAASTNGQIMPPIMGAAAFIMAEIIGIPYLDVVRAALFPALIAYLALLYVVHLESLKMGIKPLPRKELPKFWKTVLRGCHFIIPLAILIIYLVVLRRSPVASALHAIQGLMVIMLVQRPIIAFLSLGYHRKAGTLDPDLDLKRYISGAFVDGLRDLWDGLIMGARNMISVGIATATAGIIVGVVSITGLVGRFVNIIDVLSMGNMALMLVLTAMTSLILGMGMPTTANYIIMATLTAPVILHLGADMGIIFPIIAIHLFVFYFGILADVTPPVGLASYAGAAIARSDPIKTGVQAFYYSLRTVILPFIFLFNTELLMIAGVTAAGGVIWLDDPVRLAWIFFSGLIAMFAFASALQGWLVIKCRWYERLFLLLACATAFRPGVFEVYLPFDRLGMQILGVCMFFAVYIFQKIKVRRFQKFMASRAQEKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMJ7</accession>
    <name>D6SMJ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD3348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869036.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3348"/>
    <dbReference type="EnsemblBacteria" id="EFI35908">
        <property type="protein sequence ID" value="EFI35908"/>
        <property type="gene ID" value="Dthio_PD3348"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="275"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="352"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="726"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1029" mass="115713" checksum="E5366CDA5E46A196" modified="2010-08-10" version="1">MNKNQQTFPKPVVLIVDDQPASIEVLGSLLREDYHVLVAAGGTRALEMVFGNTRPDLILLDIMMPDMDGYEVCRRLKADERTRGTPVIFLTAMDQDEDEELGFSLGAADYITKPFKPSIVRARVRTQINLKLHADLLEQAAVERRELLIEYDTIFNNVQSAFFLIDIDPQGRFIIENLNAYHQEKTGLDLWNIRGKTPVQAFGPELGARIEDNYRKCFELQQNISYEETLLLPAGERTWLSRLTPVVINGRTVKLVGSALDVTDLKNAQTELLTSQSRLSWAQTLTQSGVWEHDMDQGTVFWSKECEALFGLQEGEFEGTYQAFLDRVHPDDREYVISTGRPIIEMKEGTTLEYDHRIVKKDGQICWVRESAGVVHDEAGDPLRVVGFVQDITQRKEAERAINKQKALEGLLMELAADSINAPLDDFEHTISRLLEAVGRSVEVDRVYLFNYDYVRKIAVNTHEWCAEDINPEIGNLQAVPFDLISEFIPAHERGESVHIPDVGELIENPGMRSHLEDQGIKSIVSIPLMDNRACLGFVGFDAVRKEKVFSDTEMYLLSFMAQVIVNLMSRLQASKEHQESEARCRVIAENIAMGVAVIDENMRITSANPRLRQWFPGLRPENTPLCYDVFCHTARKKVCKDCPCIVSFENHRVHQGIKRRNHKGDEQIFRLTSSPVPGPEGRVSQVVLMFQEITDEVLREEELRNRLNEAENRLAGGGPGGLCGLRGASRAMGEVYTRIRTTAGTDKVVLLMGETGTGKELAARAIHELRGRGEFMAVNCANLSPSLLESELFGHCRGAFTGASSDKKGLFEAAGNGIILLDEIEAAPSRMQTALLRVLESREVTRVGDSRPRSIGAKVLAAANQDLEAMVEKGRFRDDLFYRLCETVIHLPTLRERTEDISILADHFLEEYSRLSSRRPRQLSPRSMELLCGYNWPGNVRELRNLVHTLAEISPAPMIRPADLPDWLAGGTGGFTTLEERERKALQDAMDRASGNKTEAARLLGVSRKTVYSLIDKYGMDQGLWCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMK7</accession>
    <name>D6SMK7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35918">
        <property type="protein sequence ID" value="EFI35918"/>
        <property type="gene ID" value="Dthio_PD3359"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033C4G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="52" mass="5922" checksum="B235C0A548EA88D1" modified="2010-08-10" version="1">MCSNKKPDLKDFLDNLKKPMPLSRKAGLYFRNNLLKIRKLQSCCGNHGEPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMR9</accession>
    <name>D6SMR9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysine 2,3-aminomutase YodO family protein</fullName>
            <ecNumber evidence="9">5.4.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869108.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3422"/>
    <dbReference type="EnsemblBacteria" id="EFI35980">
        <property type="protein sequence ID" value="EFI35980"/>
        <property type="gene ID" value="Dthio_PD3422"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="557227at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="244"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="521" mass="59152" checksum="E8B3C3D6C3942646" modified="2010-08-10" version="1">MNFKEDLDEYTEELLDFLYTGKDKEDESGYGPAVQEMLVKARSGSSVQDIVDLFLYLKQARMDSGLSPDCLGLARSDAVGLAIKHQDLDEHRVSLGGRVNQAAFIVQQAGGRVDSYLEDRDREAPSGIMLWERIQENHARIREVLDMSMQEWNSFSGQLRYAIESPRTLESILNLPAGALEEVGRVTKDYRMRLTPYYAGLIMPESLDDPVLLQSVPTGEMVDNAGVEMPPVAADHSPARLIDQFYPRVVTIKATNMCAMYCTHCLRIAHIGKKDRIYPEQAYSEALDYIRRDRRIRDVLITGGDAFMLPDKVLRYMLSELDGMEHVRIKRLGTRIPVTTPQRVDQELLDILEESNDKKPVRVVTQINTAQEITPVSREAFRRISKAVSAVLNQAVLLKGINDSFVKMAHLCETIQEAYVRPYYIFNCSYRNPQFSHLRVPVEKGRDIVEGMYGNISGDAIPRYIATAGGKIPLHRSNVLDREQGDIILQKPWSGEQVRYPDADPEVYSDSRWGLKRYEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMY8</accession>
    <name>D6SMY8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sel1 domain protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869177.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3492"/>
    <dbReference type="EnsemblBacteria" id="EFI36049">
        <property type="protein sequence ID" value="EFI36049"/>
        <property type="gene ID" value="Dthio_PD3492"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087892" evidence="1">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="16795" checksum="1F73A275B9E72102" modified="2010-08-10" version="1">MKYILACLILLLFACQSPENIAFDQGMQASRSGEYETALEKWHPLAQQGHAEAQFNMGVLYENGLGVQKDHAQAADWYKKAAEQGLKEAQNNLGKNYAQGTGVEQDYIRAYKWLSLAAEQGLKEAAGNLDRISRHMSPEQVDQARRLISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN47</accession>
    <name>D6SN47_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">INB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869503.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1521"/>
    <dbReference type="EnsemblBacteria" id="EFI34173">
        <property type="protein sequence ID" value="EFI34173"/>
        <property type="gene ID" value="Dthio_PD1521"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="142247at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INB" evidence="3">
        <location>
            <begin position="773"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1571" mass="171281" checksum="411ED1D8A7F87E7D" modified="2010-08-10" version="1">MSSDGTNYPGGTRDEARLIELTQEKSFAFHLSPQEYHYYQFDADQSAMEIHVTKGDVSVELQDEDGNTLASGDQGIRYGGLEEGRSYYIQVENEAGSWWWQDKTEYHLDITPLDFLPADDPDEAVELVLEEDREATLQPGDGSHYYQFELDEARAIDIEATGSVSLTLKDSQGEKLQEGEDFLQKDSLDAGEYKVVVEHQDSRWWWQDKTEYSLGLNTAEAGRPDEPGQDPDAARVIDIWEAVSEEGKTFQEEVPAGEDHFYKFELDVDAEVGLKATGNVSLDLLREGDEGDSLQTVKADKNLIQTELAPGEYYVRVNNETGEWWWQADAEYELDFEVSPDGYEVSTYEELQKALEDSDDLLGPEGELIIHVQADIGGEGFESHGPLSYDLDHDLTITGDVTLDAEDHSRIFELDAPDHNITIDDLTLSGGNHEDGLPGGAIWAHVSSLDVEESVFVDNTGNIAVRGNDEVNTFMGTDGDDHFVVVGDLRGASKTNEPEHTALLGTQLTDLVGYNFDEDAGGSAQVINGAGGTNTLHVYGVADISNFELENVNFLEINSDVTADASDIEGMDFIKGDGGSTLRVVSGEAVEIDLSEFSGVSRLHVAEGVSASISSLGGVRSLSGTGTIAAREGALDLREGMVVERGLGLKDADGADSDRSGVREVDEVRDSDRDADVIEGGPGDDYLVGNTSDQLFLPGGGSNVIEGGGGQNIYRLEEGSDNTIHASPSDDILDLSLISEGVALDLREGGTGEDEAVGITVVVGGEAAGRGALDVHLSQDLSGSFGTDVATLRSHVDPDGDDPSLMEQLREVQPNTNFGLSGFIDKPLQDVFDTTLGGGGGDTPEYPFEEKLDMTSNADRFVEAVFDDELMEVRWGGDAPESQLSALQQIGLRGNPYDDTYENSIGFRAGATKVAIIATDVDFHEGPIMNETLEQEIPPNDGTTTLRRWKGDEDNPPDVIGPPGTGEDFPTRTQVKEALDGADIYPVILLQNYDWYRDDYEELLDYIGRGSIVPLAGRTDDVTAAILEAIGTIDQPAIQTVVGTQGDDQITGNRLNNILWGYEGDNTLFGYRGTNVLIGSTEGYDTVLLEGEMEDYEMERVDLDAFPELPNGRLDVTLGGDTGIDYGYRFVSEYYGTHYVDPTVDLVDFKDGDSFSPFAGSAPEELAIQSIDIITAGEVGSSVQIDAIVEHTRDAEEVEFTISQNGANATVTVDLEKDTPSVEEVTGIFDSTLGFEPGAVYLEVRVVEGAEVESDTKTFGLYEDEKNREFQWQWADTDKPPFDMIGHTIVDHDGLDPGTLGTGTGFMISPRHIMTNAHVLSEEDWHSDLSELNSVDFYLGRNGGTITEEQDGNLLRGEHAYLQKDEWGDKWPDTDMAIVTLDREVDGHFDWFWNARGSERDLTGEPVFLSGYPSRDLDQGTDHIGNSTYFQWTSEGTVTDYIWGYDGYGEESGGLSFTQSLSSTGGASGSPIIYQNEDNDYQFVGSYVGHSGADPVAATLDPAAYDWALDIVQDYGYLTELDYVEGPRDMGLDKALNLNEGFETDVAEAVPAEVSIQGIRDEEMDDFYFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN50</accession>
    <name>D6SN50_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869506.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1524"/>
    <dbReference type="EnsemblBacteria" id="EFI34176">
        <property type="protein sequence ID" value="EFI34176"/>
        <property type="gene ID" value="Dthio_PD1524"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZGFC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077740at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="7854" checksum="D6417A6C262C6267" modified="2010-08-10" version="1">MHVFADGISKVTLSNNNLRIQLTQRGADESTVEAGTLIIPASQANNFVNGLANSLKELDSKLKEAREQQTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNA8</accession>
    <name>D6SNA8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869562.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1585"/>
    <dbReference type="EnsemblBacteria" id="EFI34234">
        <property type="protein sequence ID" value="EFI34234"/>
        <property type="gene ID" value="Dthio_PD1585"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1818019at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021799">
        <property type="entry name" value="DUF3368"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11848">
        <property type="entry name" value="DUF3368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="162" mass="17613" checksum="5091D3C34BE45851" modified="2010-08-10" version="1">MNSILILNASPLILLGKADLLRIVGPLADFWIIPESVVAEVERKRSIGQYIAELEISSKTSQESIDEINPHVAAWDLGQGESEVLSLALQKGVGAKVVLDDLQARKCAKLFDIGLIGSVGLLVMAKRLGVIDAVKPEINKLREVGLRVDPDFLATIYQKISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNC5</accession>
    <name>D6SNC5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase, P-type (Transporting), HAD superfamily, subfamily IC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869579.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1602"/>
    <dbReference type="EnsemblBacteria" id="EFI34251">
        <property type="protein sequence ID" value="EFI34251"/>
        <property type="gene ID" value="Dthio_PD1602"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="891"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="922" mass="99397" checksum="7223EF5575259B4C" modified="2010-08-10" version="1">MLEKKDIQNKTPWHAEPVEKCFQTLKSSPEGLDPEEAGKRLETFGPNMLATEKKRGPVLRFLLQFHNLLIYVLLAAVVITALLQEWIDSLVILGVCVINALIGFIQEGKAEKSLESLKTMLAPEALVLRGGQRIRIEAKDLVPGDVVYLKPGDRVPADLRITECKSLRIEEAALTGESMPVSKAGNEVESGAALGDRKSMAFSGTMVVYGQGTGLVAATGLDTELGRISELLTETESIATPLIRKMNVFARHLTVAILLLAVAAFMFGVFLRGYAPADMFLAAVGLAVAAIPEGLPAIMTITLAIGVQKMARRNAIIRRLPAVETLGSVTVICSDKTGTLTRNEMTVQNIQTADELFWVAGVGYAPEGGFRLGDKEVHPGEHPVLMQALRSVLLCNEARFQEKNGQPKLEGAPTEGALLTASLKAGLDQDQENRVNPRKDILPFSSEEKFMVTLHHYESGDSVFILKGAPEKVVEKCSSQGALQDAAPLDPDFWVEQGNHMASMGQRLLAVAVKKAPAGKTAIEDEDIQQGFTMLSLFGIMDPPREEAIEAAARLKGRESDPGDAGAGIQVKMITGDHALTASAIGEKLGMGRGRKALTGQDLEKISDHDLVEVSLDVDIYARTSPEHKLRLVRALQEGGHIVAMTGDGVNDSPALKRADVGVAMGVTGTEAAKEASDMVLTDDNFASIANAVEEGRTVYDNLKKAILFILPTNGGQALVVMASILLGIGLMDEAGHFSLPITPPQILWINMVTAVTLALALAFEPPEKNVMQRPPRPVDESLVSGFLLWRISFVSLLLVVGALGHYLLILSHGASQSLASTAAINTLVMGQVFYLINSRFIEEPSWNLKGILGSRPVLVSIAVLAVLQFSFTYLPFMQFLFQTEPLGLDAWARILAFGLAVFVAVELEKAFFRSRSVPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNC8</accession>
    <name>D6SNC8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium/calmodulin dependent protein kinase II association-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869582.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34254">
        <property type="protein sequence ID" value="EFI34254"/>
        <property type="gene ID" value="Dthio_PD1605"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016887">
        <property type="entry name" value="UCP028470_steroid_isom-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028470">
        <property type="entry name" value="UCP028470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CaMKII_AD" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="126" mass="14653" checksum="CF8C39C17E760FDA" modified="2010-08-10" version="1">MKKKSEIEALFEEWNQALQSGDPEKVASLYAPDAVLLPTVSNQVRRNRQEIKEYFQVFLARKPKGSIDWSNIRIFEDIAINSGIYTFELSPPGETPFSVQARYTFVYQWSGERWLIIEHHSSVMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP07</accession>
    <name>D6SP07_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoA-substrate-specific enzyme activase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869805.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1842"/>
    <dbReference type="EnsemblBacteria" id="EFI34483">
        <property type="protein sequence ID" value="EFI34483"/>
        <property type="gene ID" value="Dthio_PD1842"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8032at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018709">
        <property type="entry name" value="CoA_activase_DUF2229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09989">
        <property type="entry name" value="DUF2229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="74"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="335"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2229" evidence="4">
        <location>
            <begin position="680"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1402" mass="155662" checksum="53CD0A86FF4290B8" modified="2010-08-10" version="1">MSKDNQKQGPHVLGLDIGSVSAGMVVLDQGGNVVETSYRFHHGNIAATVQGMLDGLHTREPAAVAATDQTPGFIRANHRCDDRVAVIEAARHLHGRVGSILHVGGEKFAMLFFENGRYKGLKTNTSCAAGTGSFLDQQAGRLKLSGIEELAATAASSRQEPPRIASRCAVFAKTDLIHAQQEGYSLAAICDGLCRGLAANIANTVFKHEKPASPVIFCGGVARNQAVVEHMAAMLGSRPVVDDMAHLYGALGAAVQMLERRVPGNELLDAGSIICTGEESKHYGHPPLELVQSRYPGFASRESFEFHPEQTPDGDMVEVDIYQALEKDRTYQVYLGLDIGSTSTKAVWMSRDKKVLAGFYTRTAGRPVQAMQVLLEAMDHVAWQEGVHLQIQAMGTTGSGRKFVGALAGADLVLDEITAHARAALELHPEVDTIIEIGGQDSKFTTLKNGEVTFSIMNTVCAAGTGSFIEEQAEKLGIPLQEYSDRTREVSSPIASDRCTVFMERDINYYLGRGYTVNEVLTAALHAVRENYLNKVAVESLIGEVICFQGATAKNRALVAAFEQRLDRPIHVSAFCHLTGALGVALHLLDEGVRQSGFQGLELYRQEIPVRSEVCEYCTNHCKITVADMPAGPVAFGFLCGRDYDTRHYVDNNLAGLDLVRTHRATFPAGNRVEDPGAVTVGIPTAVYMREDLSMWVDFFNRLGMATITGDKAVQDALKRGKALTGAEFCAPMTALHGQAEALAGQADYIFLPYYLEHRDKDGESRRQLCYYSQYAPTLVASVGTEIRDKLVSPVLEYLYSKLFQRMELFQAVSSMNPDKGFLEVVRAFENARSARAKARQKWRGTFNEHYSQARDINVMLLGRPYTVLDPELNKKIPQMFSRMGIKAFFQDMLKPGDKEDFDSRPFLEELHWNYASDIIKATEKVCSMQGLYPVLMTSFNCSPDSFIRDVFQELMEGADKPYLILEMDEHGSSVGYETRIEAAVRSFKNHARRQQSRIPDPAKINPVKADGMSGRTVLFPNWDPITCRLLVANLRREGIDAHLLPEGEEVIKRSMRLNSGQCIPINAIAQEFVEYVQSKDLDPSQTVLWMAHVEIACNIRLYPYRLKQMISSFGRDMHRAGVYTGSITFADVSLNAAMHAYFAFMFGGMLRRLGCRIRPREKHPGSTDQVLDKSLGIMEQAMLGSLDKETAVRDVCRLFSGIKTREKITRQAAIFGDLYVRDNPVFNQDLIACIESRGGEAITTPYTEYIRMIAPAYFRKWFAEGKYFNLIGNRAMLATMSRREKTFYSYFEKVLGEPRPEYNDPPEKVLPAYGLIPEQSGESMDNILKIHYILKHHPEVSLFVQTSPSFCCPSMVSEALAERIQEKTGVPIVSITYDGTGGDKNRKLIPYLEFAPADRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP47</accession>
    <name>D6SP47_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative addiction module component CHP02574 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869843.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1892"/>
    <dbReference type="EnsemblBacteria" id="EFI34523">
        <property type="protein sequence ID" value="EFI34523"/>
        <property type="gene ID" value="Dthio_PD1892"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HAX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034202at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013406">
        <property type="entry name" value="CHP02574_addiction_mod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09720">
        <property type="entry name" value="Unstab_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8362" checksum="CDF614B1E6B1B12B" modified="2010-08-10" version="1">MKIKDLIEAAEALPVEERALVVDSLLRSLNPPQSRIDEKWVSVAQERLKEFRSGDVETVPGEEVFAKIWGEQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP67</accession>
    <name>D6SP67_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">Dthio_PD1915</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869863.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1915"/>
    <dbReference type="EnsemblBacteria" id="EFI34543">
        <property type="protein sequence ID" value="EFI34543"/>
        <property type="gene ID" value="Dthio_PD1915"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="232152at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="300"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="332"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="414"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="424" mass="46883" checksum="A5E5575136DADB99" modified="2010-08-10" version="1">MSNIVVFGTQWGDEGKGKIVDLLTERAEVIVRFQGGNNAGHTLVTRDKKFILHLIPSGILHPDKLCLIGNGVVLDPEVLCREMDDLHQGGIEITPDSLGISRKTHLIMPYHKELDRAREQAKSGKDRIGTTGRGIGPCYEDKMSRVGIRAGDMQDSELMLAKIKKALPEKNALLQSLYQNTPLEAENVLQSIAPYADRLVPYLTDVSLKIQEAREAGRTVMFEGAQGVQLDIDHGTYPFVTSSNTITANASAGTGSYYSMDEAIGVVKAYTTRVGQGPFPTQQDNDVGEHMQVQGAEYGSTTGRKRRCGWLDLVILREAVRLCGPTALAITKLDVMSGLDTIRVCTAYEYKGQQILYPPQEENAMSLVTPVYQELPGWSQDISQCRTRLDLPRNARMYIEHIEDALKTPARIISVGPDREQTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP92</accession>
    <name>D6SP92_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869888.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1940"/>
    <dbReference type="EnsemblBacteria" id="EFI34568">
        <property type="protein sequence ID" value="EFI34568"/>
        <property type="gene ID" value="Dthio_PD1940"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HZ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1525521at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="236" mass="27797" checksum="6DC9254F05DF5E9F" modified="2010-08-10" version="1">MHKSWIDAKLPEFVRDVLRDFCQVSKELFNQFDSHDQSGHVSFTFFKELLGEEMSKGQLWRLKDTAHILFRNDQRAGKIGPYLDWCIGYIFHECMKLREDAYQQENYRPWFEARYSNPEITPEEQLISQELINVLDQTGESINREISRIKFILFHCRRLFILYLPAHADNPLLARYLFAQEDLVREVFKSSYPDLITAIYGEKPVKLYELAASSLERGGWKAEAEAARSRVSLDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPA8</accession>
    <name>D6SPA8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lipoprotein releasing system, transmembrane protein, LolC/E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD1956</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869904.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1956"/>
    <dbReference type="EnsemblBacteria" id="EFI34584">
        <property type="protein sequence ID" value="EFI34584"/>
        <property type="gene ID" value="Dthio_PD1956"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011925">
        <property type="entry name" value="LolCE_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02212">
        <property type="entry name" value="lolCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="303"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="409" mass="44460" checksum="1714DE19F9165BB9" modified="2010-08-10" version="1">MRFEFLVALRYLRAKREQAFISVISLLSVLGVALGVAALIIVLGVMNGFSENLRDKILGLNAHIVVGSHTGTIADYQDMAGDLEEIAGVRGATPFIYSEVMLSTPSGVKGVVLRGIDPQGAKQVLGLDQEMVQGGVLDLEIEKDFPGLIIGQELAANLRAGTGDTVNVMAPSGEGTSAGFTPSITTFDVRGVFRTGMYEYDTSFAYTTINDAQELMGFTRDVVSGMELRVHDADRARELSERVSEKLGGYPYYVRNWKEMNENLFAALELEKIAMGVILAMIVLVGSFSIITALVMLVMEKTRDIAILMSMGTTRRMIRNIFVLLGLMIGGLGTALGFAVGLGGCYILENYKFIRLPADVYFMEYLPVLLHTSDLIIIAVAAMVLCFLATIYPARKASGLNPSEALRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPE7</accession>
    <name>D6SPE7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869943.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1995"/>
    <dbReference type="EnsemblBacteria" id="EFI34623">
        <property type="protein sequence ID" value="EFI34623"/>
        <property type="gene ID" value="Dthio_PD1995"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="27557" checksum="ECBFEAB4DBE876BB" modified="2010-08-10" version="1">MTLRLLSLLLPAVVLSAWSILTYSGMLAPYMLPPPDQVARTMWIYVTGLEPGMYAGQFSQDLLASLSRVGSGFFLAVLLGLPLGVMSGRSRLVRVLLKDFVDAIRAVPGICWLPLALVWFGIGFKTTVFLIFLAAFFPIYINSMAGVATVPSTYIRAGMMLGLGRLGLLRHVVLPASMGHIMSGLRLGLGISFAYLVLGEMTGVPNGLGALIMDARMMGRVDLIISGIVLIAVTGLICDRLLVLAMQVVSRSARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPG9</accession>
    <name>D6SPG9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869965.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2017"/>
    <dbReference type="EnsemblBacteria" id="EFI34645">
        <property type="protein sequence ID" value="EFI34645"/>
        <property type="gene ID" value="Dthio_PD2017"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="492659at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="254"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="401" mass="45724" checksum="9E2369F3D87C77D7" modified="2010-08-10" version="1">MKRLDMDCLAAINFEIRWSSPEAVHREHFMARKANMWRDIFPADLKEALMGQPAGGEAVVSCRPGEAVPARSGQDILSTRPQNFMRREFLGRYVEPARGRFYPRGMLAGAGFFSTDMRPCRITALDEKELRVDCAHPLSDYNVEVRARLEDLATKECEIGGRMNHWMEEILGSGPGMQARTGNAPTQFAHAHGFERNDSMDDARFYSSPRFIDHIDARARGFLAGEYARELEPDMKVLDLMSSVTSHVPQDMQLQVTGLGLNPEEMQANPVLDSHVVHDLNRYQELPFNDESYDAVLCSLSVEYLTSPWAVAREVARVLRSGGIFMAGFSNRWFPPKVVRLWQELHEFERSGFVLDLLLQTNSFKDLESISIRNWWRPEDDPHTGQTWVSDPVYVVKGRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPH1</accession>
    <name>D6SPH1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2019"/>
    <dbReference type="EnsemblBacteria" id="EFI34647">
        <property type="protein sequence ID" value="EFI34647"/>
        <property type="gene ID" value="Dthio_PD2019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="49" mass="5548" checksum="1CCB3207BA52F187" modified="2010-08-10" version="1">MLPATLKGYDAGQSPDFKKTGCAVVLRLLSFLHVEFCGRMFYFFKINAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPI7</accession>
    <name>D6SPI7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH/Ubiquinone/plastoquinone (Complex I)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869983.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2035"/>
    <dbReference type="EnsemblBacteria" id="EFI34663">
        <property type="protein sequence ID" value="EFI34663"/>
        <property type="gene ID" value="Dthio_PD2035"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="130"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="499" mass="53958" checksum="AA11CF4A4BBAD337" modified="2010-08-10" version="1">MNLNVWLPLLVLASSLFAGLIIFMLDESRSRLRTALNLFAAAFKVVAVHYMAYRLLVHGEVHEVGFSMGLGFEFLLKVDFLSLMFLALSSNLWLVTTLYAVGYLEGSPNRSRFFGFFSLCVTASTGIAMAGNLITFFIFYEFLTLTTYPLVVHRETRQALEAGRNYLWYTIGGGSVLFVGIVWLHVLAGPFDFTDTGVLEALDPAHYSTLIIIFALLIAGLGVKAALVPLHGWLPVAMIAPAPVSALLHAVAVVKAGAFGIVRVVFDVYDREFAAGLGLLEPLALVAAVTIVFGSVRALMQTDLKKRLAYSTVSQVSYITLGVAILAPFSTVAAIVHLVHQGIMKITLFFCAGNIAETLGLHSIKDLGGVGRRMPVTAICFTVAAFGMIGVPPVAGFVSKWYLGLGGMDAGREWVVGIMVLSSMLNAAYFLPVVKTIWFKTPQKKWKIQRVSRFEAPLTLLLPALATASMSLLAGLWAGWTWSPLGIAKQIATGMGALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPL7</accession>
    <name>D6SPL7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methylthioadenosine/S-adenosylhomocysteine deaminase</fullName>
            <shortName evidence="1">MTA/SAH deaminase</shortName>
            <ecNumber evidence="1">3.5.4.28</ecNumber>
            <ecNumber evidence="1">3.5.4.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtaD</name>
        <name evidence="3" type="ORF">Dthio_PD2065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20716"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57985"/>
            <dbReference type="EC" id="3.5.4.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine</text>
            <dbReference type="Rhea" id="RHEA:25025"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:48595"/>
            <dbReference type="EC" id="3.5.4.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.28" evidence="1"/>
    <dbReference type="EC" id="3.5.4.31" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870013.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2065"/>
    <dbReference type="EnsemblBacteria" id="EFI34693">
        <property type="protein sequence ID" value="EFI34693"/>
        <property type="gene ID" value="Dthio_PD2065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090614">
        <property type="term" value="F:5'-methylthioadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050270">
        <property type="term" value="F:S-adenosylhomocysteine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01281">
        <property type="entry name" value="MTA_SAH_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023512">
        <property type="entry name" value="Deaminase_MtaD/DadD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="47"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="418" mass="47139" checksum="352C7AC259A18124" modified="2010-08-10" version="1">MSSLLIKDVLLKDRIVDVLIRNGRFQDIAPGLEEPEAQVLDGRDKAILPSFINSHTHAAMTLLRGYADDLDLHTWLTQHIWPFEHQLTFNDVYIGAKLACLEMIKTGTTFFCDMYWHMPATLKAVEEMGIRAALSSVFIDFGDPAKAKQFRSRTRKFFRENDRHERIIFCLGPHGIYTVSRDSLVWVSEFAREHDLLIHIHVSETRKEVEDCLQENGLRPVEYLESIGFLGPNVIACHSIWLTEKEMDMLARHGVKVVHNPVSNMKLASGLFPYQDMRKRNICIGLGTDGCSSNNNLDMLQEIKTGALLGKSSTGEPTVFPAQEAWECATINGGEIFGLEAGTIAVGQLADCILVDLDHHTLIPRHDLISNLVYSASSECIDTTICNGRVLMQGRKVPGEEQIIQEIKEWEENLKNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPN2</accession>
    <name>D6SPN2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34708">
        <property type="protein sequence ID" value="EFI34708"/>
        <property type="gene ID" value="Dthio_PD2080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="290" mass="33110" checksum="8468D7ABAEDE66CB" modified="2010-08-10" version="1">MPQTGKEGSNGKTEEEEEKEGQKRRQNKKYFFFSLLEEDTRIRYKQFQTGIIKTYSGWRSHADGEYTYWGLNLPGMVKWWMDFSDTPKGYSFVSTKYNCAAVVAQCLLEGCADAYIDIKQPKMYYTPNDISALADKLVNRLDDLNIESRRLINNSRQSLDRPGIWTSEEFYKASYAGRFARRKGQVASIDDLLKEYHKAGPWDKNNFPQKFTALARMMQNVLDHRQKKAGSDRGSAVETLGLQIIAELSSEELLIAQNNNAGGSLAALLSLCEEGNNRTLDQSFKKAKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPQ0</accession>
    <name>D6SPQ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870044.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2099"/>
    <dbReference type="EnsemblBacteria" id="EFI34726">
        <property type="protein sequence ID" value="EFI34726"/>
        <property type="gene ID" value="Dthio_PD2099"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033T1P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308353at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="540" mass="62293" checksum="AD04898924248084" modified="2010-08-10" version="1">MFTDAIELNLKLTISQKSVDIAAGNVKLWELDLHNWGFTGRAEFAVSLVHEDDSLFELFTGSETVQVELKFKPYYIPEGTSVEYVELKGLVTHKAITAEQTIERGPLKGNPVVYRMYEIFFVDPAQAVWKCHRPLELMTDKSVKDLLQAHKTSRINLNFQWKVLNEKLPMLALYLGSEAGKADFYDFVMWYVDTRNGIWSFDASKNSYTLSETKDTEGEPDNLNKDAVQSLRMDFPEPPRERLRLLNSFAENPQTKKIENKLAMEGITRDILVNYPVTSDLNNREALEKKRQKIREHELLLYFSSYPMLCLIPGKFLKLEKGLWSENLYTTGKTYRIRSLHIKAGATDANPDSDRDMPFNRYEMEMCSRLETKDETWQELPEYVPPAYPVYLEGLVVSEHGDKDEETYQIHEDSKTSQRYYKVKIPLLNNQELLMPFMPLIQSGHFYFPVYKGARVLVALEFDHATMAGCLDWRGEAQVPADTQGNRIMMGKTPTSRTAISHVYQDNLPVFAMERQEEKDTESITFSQGRLVIQTSEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPQ8</accession>
    <name>D6SPQ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870052.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2107"/>
    <dbReference type="EnsemblBacteria" id="EFI34734">
        <property type="protein sequence ID" value="EFI34734"/>
        <property type="gene ID" value="Dthio_PD2107"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="3">
        <location>
            <begin position="154"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="319" mass="34663" checksum="2E68A3BC0EF5DB32" modified="2010-08-10" version="1">MQAVIFHETLRYVQDHPVPGPEKGQARIRVNLAGICRTDLEIMKGYKGYKGILGHEFTGVVESCNDASWVGKRVVGEINAACGLCEWCMAGLGRHCPNRETLGISGLDGCMAEYCVLPVTNLFSADGLSEERAVLTEPLAAACEILEQVPLQGNERVVVLGDGRLGILCAWVLATVAGRVTLRGHHRDKLELARWRSLETSLRGEGIEPGADVVVDATGSGRGIEQAMDLCRPRGTIVLKSTVALQGEVNLAPLVVNEITLVGSRCGQFSHALDMMHRFPDMPLERLITHRYPLHQALEAFETAQSGEALKVILEVHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPU3</accession>
    <name>D6SPU3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CRISPR-associated protein Cas1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2145"/>
    <dbReference type="EnsemblBacteria" id="EFI34769">
        <property type="protein sequence ID" value="EFI34769"/>
        <property type="gene ID" value="Dthio_PD2145"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="264" mass="30635" checksum="413BC9B54F30D43B" modified="2010-08-10" version="1">MLSFFPWNTVHFAVECCPFSREIRSKLENMARMLQVRGKRMKNQELLSKAAAIRALGKELGSLQDVELIRGCEGHASRLYFQVFDHLLTNKNFSFKGRSKRPPKDPVNALLSFVYTLLTNEVQTAVKTVGLDPYLGALHVIDYGRPSLACDLVEEWRAFLGDRLVLGLINKKSISVDDFVYRDVKDTDFVDEKDLRSKRPVEMKPAICRAFLQSYEKWMQQKILDPVSGKEFGCREYIFKQVQRFEKHLSQKEKYQPFLWAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPU9</accession>
    <name>D6SPU9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34775">
        <property type="protein sequence ID" value="EFI34775"/>
        <property type="gene ID" value="Dthio_PD2151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="50" mass="5603" checksum="62703595FE51D940" modified="2010-08-10" version="1">MHGHRAFINPAMPHCIHAFLPKSEIVHTLNIKLQKLGHSSMLESLSWTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ44</accession>
    <name>D6SQ44_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34870">
        <property type="protein sequence ID" value="EFI34870"/>
        <property type="gene ID" value="Dthio_PD2261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="30" mass="3030" checksum="12920BC2D0AADC40" modified="2010-08-10" version="1">MVAGFLTILALVCAAGGVLALVMHMKTVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQB4</accession>
    <name>D6SQB4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870254.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2332"/>
    <dbReference type="EnsemblBacteria" id="EFI34940">
        <property type="protein sequence ID" value="EFI34940"/>
        <property type="gene ID" value="Dthio_PD2332"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033KC6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2070234at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="60" mass="6927" checksum="12C5ED042C278FE0" modified="2010-08-10" version="1">MVIVVKKCSSECPFCNTLENGKMECNVSMPSKRPIPEMEEKFPSFCPLKREQVITRAFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQT9</accession>
    <name>D6SQT9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870429.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2509"/>
    <dbReference type="EnsemblBacteria" id="EFI35115">
        <property type="protein sequence ID" value="EFI35115"/>
        <property type="gene ID" value="Dthio_PD2509"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="163"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="335"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="535"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="789"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="925" mass="101933" checksum="4CB0BEAF2333EDB6" modified="2010-08-10" version="1">MSQDFFDPEVYSDFVVEAREHLETIEPKLLELENNPGNLSLLNDIFRPMHSLKGASGFLGLKDMNALAHKGENILDELRQGRIQANSSIMDLILEATDALRTMVDNLESMGHEGSLEVGHIIEHIDEILKNKDEQASSGAPAQEVQKEEQDFSHPAAEQNYLLNMVSLDHLSDFIEEAQENLTAINSLLLEMEKGEGSSQDRINDLFRNFHNLKGNSGIIGYIELNALAHEVETFLNTIRSGEQVLDPEAVDVLLETVDVLESLLGNIDRETGEVQPESISGITSRIKELKKRFQVHQDEEDKAKDNGAREEAENIFAQAPADNEVAGQQQGDNDPEVDPQDLQIFRQTVDQQFSNMKHALDKLEKEGTDKELVDGLYRSLVTVQNSTGYMGFEELKNYASNTANLVDQGRKTDTDFSLMHGILKQEVDILESMINRHLSGLSSTVQDLPAQPSPEPDRETSAEKPSEASRVSSDPQEEAEPFAPAMDIPEQQQAQAASQAGESAEPSGAGKSADQGAGSEPQAKSQGSTTSTIRVDHGKLDELMNLIGELIINRNRFAMLSRSLEEGQDVMEVAQQLNETTNSMARISDDLQVTIMNVRMVPVRSVFTKFPRLVRDLSRKNNKNIQLITEGEETELDKSVVELIGDPLVHLIRNAVDHGLELPQERKDRGKEEKGTVWLRAAHKGNSVVIEIEDDGKGIDPEKMKAKAVEKGIIDREEARNMEEDQAVDLIFAPGFSTAETITDVSGRGVGMDVVKNNIKSLKGNISVTSAVGQGTRFSIALPLTLAIIDALMVKVNGQVYAIPLDAVSETTKIQAGRLNEINNRKVITLRGEVLGISDLAELLELPVDQADRDELPLVIIKVGDRRMGFIVEDLLERQEVVIKSLGEYLGDQPGISGATIMGDGSVVLILDPNEIYRIATSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQY3</accession>
    <name>D6SQY3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module toxin, RelE/StbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870473.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2557"/>
    <dbReference type="EnsemblBacteria" id="EFI35159">
        <property type="protein sequence ID" value="EFI35159"/>
        <property type="gene ID" value="Dthio_PD2557"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="10816" checksum="B19AA51FD4714F69" modified="2010-08-10" version="1">MTWQISFTPGAEKELKKLGKQESQRITRYLKERVTQDPRALGTVLKGQLREFWRYRVEDYRVLVKIQDEKLLILVIHRVHRSKSYFAVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR41</accession>
    <name>D6SR41_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870520.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0480"/>
    <dbReference type="EnsemblBacteria" id="EFI33157">
        <property type="protein sequence ID" value="EFI33157"/>
        <property type="gene ID" value="Dthio_PD0480"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10940" checksum="6F02F8EAA30176AC" modified="2010-08-10" version="1">MIKSFKDQNTQKLYSGLFVKEFSGFERQAIRRLQILDNATSLNDLKGLPSNRFEALKGKRKGEYSIRINRQWRICFKWDEEGPREVGIEDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR42</accession>
    <name>D6SR42_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0481"/>
    <dbReference type="EnsemblBacteria" id="EFI33158">
        <property type="protein sequence ID" value="EFI33158"/>
        <property type="gene ID" value="Dthio_PD0481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10329" checksum="1BA6C7EC7AC8D862" modified="2010-08-10" version="1">MSKTMTSREFNQYAGQAKKAAEAGPVFITDRGKPCHVLLSALIRKFGDVFSMSPIEPKNWALTLLNPKSEYRNSKQIRNSNSPIPQFPNSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR86</accession>
    <name>D6SR86_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar L-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Basal body L-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">flgH</name>
        <name evidence="8" type="ORF">Dthio_PD0528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the FlgH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870560.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0528"/>
    <dbReference type="EnsemblBacteria" id="EFI33202">
        <property type="protein sequence ID" value="EFI33202"/>
        <property type="gene ID" value="Dthio_PD0528"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009427">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, L ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00415">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000527">
        <property type="entry name" value="Flag_Lring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34933">
        <property type="entry name" value="PTHR34933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02107">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01008">
        <property type="entry name" value="FLGLRINGFLGH"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008952677" description="Flagellar L-ring protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="233" mass="25239" checksum="821B3C1CA51D016A" modified="2010-08-10" version="1">MKSYKLIIIVAMAFFLGACAPAQKKSTPMPSYGPEQYPDPGAVTEADSPSLFQPNRTQFLFGDNRARNVGDIVTVHIEESSDAESRANTEYDRDSTMDLSSMPISAATGAIFPGAGTPGEMQQQFQSQSDRDFEGDGTTSRGSDVQASVSARVVEVLDGGVMHVEGARQIKVNNETQIIAVRGLVRSRDVDSNNSVSSTQLADAQIEMYGEGILADQQRPGWLTRVLGRVWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRF4</accession>
    <name>D6SRF4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ruvA</name>
        <name evidence="10" type="ORF">Dthio_PD0596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870628.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0596"/>
    <dbReference type="EnsemblBacteria" id="EFI33270">
        <property type="protein sequence ID" value="EFI33270"/>
        <property type="gene ID" value="Dthio_PD0596"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1370858at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="203" mass="22020" checksum="CB959644C4A45DFE" modified="2010-08-10" version="1">MIALIRGTLVSFNDKSCLVMTASGLGYEVHVSAMGLQNMPGQGEELELHTSMVVREDALDLYGFFTRDERETFNVLLNAPKLGPKTALAILGIFSPSQIQKIINTEDEAALTQVPGIGSKTARRLILDLKDRLGFISPQHEDPRPAPGPRGVRQDVLAGLTSLGYSAAEVTPLLDEVLEKEPDLDVSSAIRAVLKEKAREKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRG2</accession>
    <name>D6SRG2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FeoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870636.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0604"/>
    <dbReference type="EnsemblBacteria" id="EFI33278">
        <property type="protein sequence ID" value="EFI33278"/>
        <property type="gene ID" value="Dthio_PD0604"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="3">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="11830" checksum="BFBF063CCA46E5AC" modified="2010-08-10" version="1">MFKMWFGRKQDTQECPHRPPECQNLRTLDCLQLDEEGEIDSIPDQALLEPLGFRPGKKVCLRCRARFGGPLVAEIEGRHTALGRSVARQIKLRKQLDLCPENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRH6</accession>
    <name>D6SRH6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870650.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0618"/>
    <dbReference type="EnsemblBacteria" id="EFI33292">
        <property type="protein sequence ID" value="EFI33292"/>
        <property type="gene ID" value="Dthio_PD0618"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="137" mass="15830" checksum="EA63A5835CBFAA27" modified="2010-08-10" version="1">MLQLILKDTVTPCRARMIARGVKAFLDTFVTSDVLFDIELVLTESCNNAALHAYQGLPGELEIKLDIVENEQVGLQVRDWGREFQCPWTLPDNNQESGRGIYIMRQVMHTFDYSRVEDSNVFSFTKKVEPEQWKECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRL6</accession>
    <name>D6SRL6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HicB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870690.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0660"/>
    <dbReference type="EnsemblBacteria" id="EFI33332">
        <property type="protein sequence ID" value="EFI33332"/>
        <property type="gene ID" value="Dthio_PD0660"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="109" mass="12240" checksum="CBDE9C2012598687" modified="2010-08-10" version="1">MAQKNDKYTYRVTWSEEDNEYVGLCAEFPGLSWLADTPEKALKGIRKTVAEVISDMGENKETIPEPIACKRYSGKFMVRIPPHVHRKLAIQAAESGISLNRIASSKLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRN6</accession>
    <name>D6SRN6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate/ketoisovalerate oxidoreductase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870710.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0680"/>
    <dbReference type="EnsemblBacteria" id="EFI33352">
        <property type="protein sequence ID" value="EFI33352"/>
        <property type="gene ID" value="Dthio_PD0680"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1777574at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="179" mass="19713" checksum="F8F5B365D84419F9" modified="2010-08-10" version="1">MWEIRLHGRGGQGAVTSAELLARAAISREKFAQAFPSFGPERRGAPVQAFVRVDDKKIRKREKIYQPDMVLVLDPSLLDVVNVAEGLKEDGIVVVNSPQDSAELKQKHNWPGAYTVDATKIAMDILSVPITNTTMLGALLKASGILEPQDMEEVIMDRFGPKLGPKNFEALKKAYELAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRP7</accession>
    <name>D6SRP7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fimbrial assembly family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0691"/>
    <dbReference type="EnsemblBacteria" id="EFI33363">
        <property type="protein sequence ID" value="EFI33363"/>
        <property type="gene ID" value="Dthio_PD0691"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="617" mass="70158" checksum="C985FD9D0D07756A" modified="2010-08-10" version="1">MATRNDIDSTEKLLNLIRKGPSQSVTEGHAPRRSASPLWTSLRNRVLPFRSTKVMGLEILRDSLHLALSEQTRSGWRLLHASSVDIPADMTVDTPEFKDFLQNQLQDLDPRKTAEVWFALPASRGEIWSIRVPRVKKGMANVVYWSARKEKNFDPQQHIFNFRLGREVDEGGVRKIQAEICLAPAEDIQKYRQLITDTGYRLRGITLPAASLDNLFQHARDDYLDKPYAILYIGEDSSCIKFYSAGTVLFSRVIRMGQDSFLDSINMEHSRQDQEGHDLSDLQVSSSTNLLEESSGSREKALQILKQLQHDGRKSSEDDDKSPSSALDLIYPALERLSRQLERTIDQLVKVMDHPAPEELFICGKIAFLQGIADFFSQNLDIPAQILDVPSSPNVQVENTITEMEPDERLSLVSTVGLTMPWSGTVNFLHTAMDKEREAAAMRNTNLVAAGCALAFVVVAGYWAWMGHQLEQAREETLSLQDQLSEYSPRLTRDMLQDLVEEHQDFKDTVINRAQRLQAVALIGEIGRITPDDFRLLEMILELDSQTDEDERRQNLIVEGFIRGEGDNFETRMTSYLVDLRNSPLFRSAHIHRSSRGTLEEEGEVFRFVLNIDPERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRQ6</accession>
    <name>D6SRQ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33372">
        <property type="protein sequence ID" value="EFI33372"/>
        <property type="gene ID" value="Dthio_PD0701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="10603" checksum="D8CE988C16D2AF3E" modified="2010-08-10" version="1">MAGDIIGRYGRTGQDELARLPPLVNRKPDMIPDGWFNLPFINKTRGSARQYQARVNDYSLTGILIDIKQYFTGGQIPGSSRFSAGFRPFNDHGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRV4</accession>
    <name>D6SRV4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0753"/>
    <dbReference type="EnsemblBacteria" id="EFI33420">
        <property type="protein sequence ID" value="EFI33420"/>
        <property type="gene ID" value="Dthio_PD0753"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="8"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="38859" checksum="79C003EADBC0AFDF" modified="2010-08-10" version="1">MSDTSKYHDHTFRAILGREPVARDFVRYHLPEEITRDMNLDTVKVSSRSYVSDNLKESMTDLVITLQLNTGEPAEIYILVEHKSDLDAWTKIQLFKYMNEVWQSFIQKKTGTLPIIVPLVFYHGTARWNYSLEFSDLFNLPSKHYRKYIPKFEHLLHEVPEINKKKAKTSITLEVFHLVLEYIFYPEKRDQIYEALELLFKGLDAKEAHEIFAILIKYLLIATDETPEEAEEKVKHLPKGGETVKTTAEVLRQEGYHEAIKEKPMWQKEAKVENSQENLIDVATEVYGPLPGSLYEKIKSIQSLENLRALNRKVIRTQSLEEFSELVNRAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS55</accession>
    <name>D6SS55_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870871.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0855"/>
    <dbReference type="EnsemblBacteria" id="EFI33521">
        <property type="protein sequence ID" value="EFI33521"/>
        <property type="gene ID" value="Dthio_PD0855"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2025675at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10191" checksum="057126629C4B578A" modified="2010-08-10" version="1">MKAITLRGIDPETSEKLKQAASRQGKSTNRLILEMVKKELGLDKEQKYSREYSDLDDLFGKWTEREFREISDKISRERQIDPELWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS83</accession>
    <name>D6SS83_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870899.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0883"/>
    <dbReference type="EnsemblBacteria" id="EFI33549">
        <property type="protein sequence ID" value="EFI33549"/>
        <property type="gene ID" value="Dthio_PD0883"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RPF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1899410at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="134" mass="15169" checksum="A7743929811A4CC6" modified="2010-08-10" version="1">MSEIEAFLEDWQEDPRGIKPVFKWLALELEDKGAELELVIRTGVTASLRAKLPEQSNRPLFCLVDVVEDADGRWLSVCFYADSVSDPEELGNPVPQGLLGEDGYCFDLEEPDAEFENYLYPRMDEAIAFARIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS92</accession>
    <name>D6SS92_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870908.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0892"/>
    <dbReference type="EnsemblBacteria" id="EFI33558">
        <property type="protein sequence ID" value="EFI33558"/>
        <property type="gene ID" value="Dthio_PD0892"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="547" mass="60514" checksum="F24971E51924E7BA" modified="2010-08-10" version="1">MKELGRLLSIMLPQWKWLLLGMLCSLVTLLANAALLSLAAWFLACMALAGITGVPFNYHLPAGGIRTLAIVRTAGRYAERLFSHEATFRLLAHMRVWFFSRLEPLAPAGLASIHSGDVFSRIKADIDHLDQFYLRFVLPLCTAAAALLAVFLFAGWFSPALALYLCCLWILAGGVLPLVLLRQGMSIGQGQVQSLSRMRTLGVDLIRGLEELVVLGQTKSILDELDKENKIQTSIQARYSKLEAWAEGGMTLFVGLSVWGTLIIVIPLVQSGKISGENLPMLAVLALLSFEGVQQLPSAFKAWGRIRASARRLFSIIDQNPLVQDPPEALPAPEQFSIEFREVSFSYPGRSKQVLKSMSFQVRFGEKAGITGPSGAGKTSIFNLLLRFYPLQQGQILLGGRNIQDYRAEDVRSWTGVVSQDCFLFNSSIRENLLLASPHARDKDLWQALARARLEDFVTSLPDSLDTRVGQAGLRLSGGQARRLCIARTLLKDTPILLLDEPTEGLDKDTEAALWDTLQEVMAQKTVILITHRSMGLEYMDRVISMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSE6</accession>
    <name>D6SSE6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="9" type="ORF">Dthio_PD0947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870962.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0947"/>
    <dbReference type="EnsemblBacteria" id="EFI33612">
        <property type="protein sequence ID" value="EFI33612"/>
        <property type="gene ID" value="Dthio_PD0947"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="24849" checksum="7141AA3A7FC9A851" modified="2010-08-10" version="1">MNSLIFGPNGSGKGAQGSLVKNKYNLAHIESGAIFREHIKQGTELGQKAKEYIDKGELVPDEITVPMVLETLKKEGQGGWLLDGFPRNPAQAKMLWDALQKEGMKLNYVIEVQLSRDAAKKRIMGRRLCANDPNHPNNIYVEAIMPDGDKCRICGGELKARSDDQDEEAIDKRHDIYYDTENGTLAAAYFFKDLAAKEGFKYIELDGSGSIEEVKDALQKQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSH8</accession>
    <name>D6SSH8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870993.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0979"/>
    <dbReference type="EnsemblBacteria" id="EFI33644">
        <property type="protein sequence ID" value="EFI33644"/>
        <property type="gene ID" value="Dthio_PD0979"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1956590at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038756">
        <property type="entry name" value="CheX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39452">
        <property type="entry name" value="PTHR39452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="158" mass="16622" checksum="A1068729876EE3DE" modified="2010-08-10" version="1">MTEKVKKIIVIFAQAGINVLETMAMVKAGLGKAYIKKDQKAVGDVSGIIGFSSKSGSAKGSMSVTFSEASALGIVGSMLGEEYPEVNDEVKDAVGEMTNMICGQARKDLVEMDMIFEAGTPSVVTGKNHTIRHVSERAILAIPLDTSHGSLSIEVCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSM1</accession>
    <name>D6SSM1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871036.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1026"/>
    <dbReference type="EnsemblBacteria" id="EFI33687">
        <property type="protein sequence ID" value="EFI33687"/>
        <property type="gene ID" value="Dthio_PD1026"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="27504" checksum="20851817FCA49AB2" modified="2010-08-10" version="1">MPRYAMVIDLQRCGGCGACITGCKYENNLPEGVRWSNKMTETLGTFPNVRYYYRPTLCNHCENAPCVRGCPTRALHKVEGGITAHDPNKCIGCRYCLVNCPYGVINYTWNKPHREWENDDAVIPDCTMSPREQARALNVPNWPLYNPDPDYNYQAIRPTGVVEKCHFCRHRVVNGELPWCVEVCPCDARIFGDLDDPDSLVNRVLGLFRAEKLRPELGTEPRVFYVREFCPCVYEAGKGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSP2</accession>
    <name>D6SSP2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1047"/>
    <dbReference type="EnsemblBacteria" id="EFI33708">
        <property type="protein sequence ID" value="EFI33708"/>
        <property type="gene ID" value="Dthio_PD1047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0798">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="396" mass="43454" checksum="3225B5C3F137D425" modified="2010-08-10" version="1">MAEIKVSKEMSVLDRFLTVWIFTAMVVGVLTGFLFKGPVETFNEALTVGEHTNLLIAFGLILMMYPPLAKVKYELMPRVFSDFKILGLSLLQNWIVGPILMFTLAVGFFGYIAPAIFGPDERWGYYMVGLILVGIARCIAMVLVWNTLARGNSEYAAGLVALNSVFQIIAFGLYAWVFITVLPPLFGMEGMVVDVTIGEIFASVMIYLGIPFGAGILSRVILLPIKGHDWYDNVFVPKIAPITLIALLFTIVVMFSMQGEQIVHRPFDVLWIAIPLTCYFVFMFLISFFMASRLGADYSRSTTLAFTASGNNFELAIAVAIAVFGIASPIAFATVVGPLVEVPVLIGLVHVSLYFLRKYFGGVVRDDGLQTQDAGYGGQGTCAVGERVYPSISTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSQ2</accession>
    <name>D6SSQ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anti-sigma-factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871067.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1057"/>
    <dbReference type="EnsemblBacteria" id="EFI33718">
        <property type="protein sequence ID" value="EFI33718"/>
        <property type="gene ID" value="Dthio_PD1057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="128"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="242" mass="26882" checksum="D2A1E9103DD20472" modified="2010-08-10" version="1">MQKVLVIDDEKPTLSMFQLFLKAYGYSVYTAESGEKGLEIFEQEKPPLVISDIKMPGMDGIQVLGRIKEMSPHTEVIIITGHGDADLTIRAMELNATDFLHKPIEKNALQNALKRAVERLGILESSEEQIALSSINGTAIVDIQGNINASHEKRLQEIYQEINEQGKTGVLFRFNPNSSVNGTGIAVFIQILSMCRDNGQKAVITGLSENFQKFFHLVGITRMAEIYEAEDQALSRLQEQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSQ7</accession>
    <name>D6SSQ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1062"/>
    <dbReference type="EnsemblBacteria" id="EFI33723">
        <property type="protein sequence ID" value="EFI33723"/>
        <property type="gene ID" value="Dthio_PD1062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9631" checksum="FE74A142A101EEE9" modified="2010-08-10" version="1">MPATQIRKEFLAHRSHRLTQIKEIEEACFFLAGIRTRKEKGISRLRGGGDHLSLVSKNETVPVPSAEPPSWLKFFLYFVTGFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SST3</accession>
    <name>D6SST3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871098.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1088"/>
    <dbReference type="EnsemblBacteria" id="EFI33749">
        <property type="protein sequence ID" value="EFI33749"/>
        <property type="gene ID" value="Dthio_PD1088"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="148" mass="16300" checksum="0B5B8A8C73D366AE" modified="2010-08-10" version="1">MNQDMQTSRHHSRGAYPSLPRVAVGAVVRLEGSFLLVQRANPPAQGQWSIPGGKIRLGESMQQAAEREVLEETGLTVRAGLPVLTFDLIHRDKAGNILFHYVIVDLWAEYVKGRIRAGADAARAAWIAPENFPDFNLSPTTLDLLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSW1</accession>
    <name>D6SSW1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871126.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1116"/>
    <dbReference type="EnsemblBacteria" id="EFI33777">
        <property type="protein sequence ID" value="EFI33777"/>
        <property type="gene ID" value="Dthio_PD1116"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="2">
        <location>
            <begin position="160"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="346" mass="39434" checksum="E6E1142F2DDD47E4" modified="2010-08-10" version="1">MQTKKYFVQDIRAGQQIDDTFMVIRARQAQARNGPYWQLTLQDRTGEIQARVWNPLSRQFQDIPQEQLVRIRASSQVFGDQLQLNIDDMHFIDQDQADPGLFLPVSCTPPEELHQNLILFLQQNVSYPGWKKLVKKILTREEIKEPLLKAPAAKSIHHAYMGGLLEHTLSVCRICNQICDLYPDLDRDILLCAAALHDLGKTMEILPGASRDYSHQGKLLGHIFLGLDMINPFLDKAKELDEDLIMHFKHIIISHHGELEFGSPKRPKTREAFVLHFADNLDAKIKTLDQALAGGDESEESAGTWSDYQRSLGRFVFQPARTPRPPESPREQGGKKEGQCLLPLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSX9</accession>
    <name>D6SSX9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin B12-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1134"/>
    <dbReference type="EnsemblBacteria" id="EFI33795">
        <property type="protein sequence ID" value="EFI33795"/>
        <property type="gene ID" value="Dthio_PD1134"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="101"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="25052" checksum="9A2BDA960D405F60" modified="2010-08-10" version="1">MNKQASCISKENPYCELAQSYLDCIRGSSRNEAVRLILDAVNRGVDIQDIYMYVFQPVQYEMGRLWLANQISIAQEHYCTAVTQLIMSHLYPRIMTFEKNGLSMVACCVGGELHELGIRMVTDLLEMKGWDTYYLGANMPEKEVVRSVKDQNVHLLAVSATLTSNRPRVEAIIKEVRQTPGLEGVKIMVGGHAFLQEPGGWEKIGADGSAMDAVQAVELAFSLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST07</accession>
    <name>D6ST07_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871172.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1162"/>
    <dbReference type="EnsemblBacteria" id="EFI33823">
        <property type="protein sequence ID" value="EFI33823"/>
        <property type="gene ID" value="Dthio_PD1162"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="145"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="354" mass="40732" checksum="B3977AD7396A4ED4" modified="2010-08-10" version="1">MQETRAVRRKKLKKNLAEKDVHAHLITSPANRYYLSGFELHDPQCNESAGCLLVTREKDYLLTDPRYLEEGKAYFPEEDIFVYTRDKYKQIKSYLNKTGIYRLGFEPQWMNYEFYAAISQEFEMVPLKGLVEDLRFVKDKRELDLVKKSCALNHKVFTRLEQILRPGLREKDIAWEAEKMFKEEGASEMSFSTIVAAGERSALPHASPGDRELRDGMPLLVDMGGRYQDYCSDQSRTFWIGSKEDVFFRQTRDLVRKAQDLVIEWMAPGRSISEAYQIVSSFFAEHGVDRHFTHSLGHGIGLETHEAPSLGPNAKGEFIPGMVVTVEPGLYYAGWGGVRWEYMVLVTRSGVEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6STE6</accession>
    <name>D6STE6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871311.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1301"/>
    <dbReference type="EnsemblBacteria" id="EFI33962">
        <property type="protein sequence ID" value="EFI33962"/>
        <property type="gene ID" value="Dthio_PD1301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2088338at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023081">
        <property type="entry name" value="Cell_div_FtsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37485">
        <property type="entry name" value="PTHR37485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10855" checksum="6844D63BDBBA2DEC" modified="2010-08-10" version="1">MLIRLIVLILLGANIVLAYQLYWGPSSVPVYLENKETFQELKQENKALLEENKQLSKEIKHLRSRKDFIKEAVRKEMGYVREDEVMYYFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6STF3</accession>
    <name>D6STF3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="16" type="ORF">Dthio_PD1308</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871318.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1308"/>
    <dbReference type="EnsemblBacteria" id="EFI33969">
        <property type="protein sequence ID" value="EFI33969"/>
        <property type="gene ID" value="Dthio_PD1308"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI33969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="555" mass="59064" checksum="F5784BC34FAC88C8" modified="2010-08-10" version="1">MRSHKMTRGIEKAPHRSLLYSLGLTREEMERPLVGVVNSANEIVPGHQHLNRISRAVKDGIRMSGGTPMEFSTIAVCDGLAMNHAGMRFSLPSREIIADSVEIMASAHPFDALVLIPNCDKAVPGMLMAMIRMNLPSIIVSGGPMLAGEDRGKTVDLISVFEGVGRVKSGQIDQEELQSLEQNACPGCGSCSGMFTANSMNCLCEAIGLGLPGNGTIPAVYSERIRLAKTAGMKVMQLLKDDLRPKSILTPKSVANAVAVDMALGCSTNTVLHLPAVFAEAGLELNLDIFDVMSRKTPNLCRLSPAGPHHLQDLHRAGGIPAVVSELAGKSIFDLNSMTVTGNSWRKNLEDLQARVLDPQVIRSMDNPYSSGGGIAILRGNLAPHGAVVKQSAVTAEMMVQTGPARVFEGEEDAVQAILDGQIRQGDIVIIRNEGPKGGPGMREMLTPTSAIAGMGLDKHVSLITDGRFSGGTRGAAIGHVSPEAAEGGPIALVMEGDEISIDIYKGSLNLNVSDQELEKRRQSLKPLEKEVDSPLLRRYARMAGSASTGASFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STG5</accession>
    <name>D6STG5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1320"/>
    <dbReference type="EnsemblBacteria" id="EFI33981">
        <property type="protein sequence ID" value="EFI33981"/>
        <property type="gene ID" value="Dthio_PD1320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="38" mass="4751" checksum="380474A631EE0181" modified="2010-08-10" version="1">MSRHKKIERHKEIDRRRRRKKKRLKQRKKEAIQAAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6STP0</accession>
    <name>D6STP0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871405.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1395"/>
    <dbReference type="EnsemblBacteria" id="EFI34056">
        <property type="protein sequence ID" value="EFI34056"/>
        <property type="gene ID" value="Dthio_PD1395"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="694" mass="77279" checksum="4E33012B2B553C2F" modified="2010-08-10" version="1">MTDNKVYSVCGMCTVRCPIEVEVHGDQLKFIQGNPHSALKGALCARGGAGAGLINDPDRIRHPLIRTGKRGEGQWRKASWDEALDYVADKLGGIIQEHGGRSLLWSDRGGPFRDLHQAFVRGLGSPNYSNHDASCARNVQHAAMSVMGYGRKGVAYDLKNAKHVVLQTRNILEAINVKEVNDLLDAVDNGCKVTVIDVRATKTAGKADRFLMIRPGTDYAFNLAVINELINKNLYDADYVHSFVQDFDQLRNFVQDYTPEWAEKKTGIKAREIRDFVVDLVKAMPSVVWHPGWNTARYTDSFYVSRTIYIINALLGSIGVKGGLPFMAKPGDCGSKGLKALASLYPKPEDERADGVGTRYGHFDPGPGLLHLGFQAIEKQDPYPVKAYIAYRHDPFMAFPDPEALKKITDNLDLMVSVTFSWSATAWNSDVVLPLSPYLERESIIAAKNGLKPHFFVRHRALPPKYDTRADWEILCGLSQKMGLDKLAFESIEDIWRYQLADTGVKPEDFKATGMVSLTDKPIYFPREQFKFKTASGKIEIIAPKWEEAGIPSLKPYEDKQAPKKGWFRITFGRCGVHTQGHTQNNPILHEQMPENELWINDKKAAEMGISNNDLVKVSGSNGYSGKIKAYVTEFMHPDAVFMVHGFGSDVPAETRARNKGVADHRLMKGGLDIWDPAGGAVALQEHFVKVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STP4</accession>
    <name>D6STP4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871409.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1399"/>
    <dbReference type="EnsemblBacteria" id="EFI34060">
        <property type="protein sequence ID" value="EFI34060"/>
        <property type="gene ID" value="Dthio_PD1399"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SDN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1896848at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="208" mass="24258" checksum="C84641A485EE1FA8" modified="2010-08-10" version="1">MNWWDHLIIMLDLVLIAPYRWFENPVNGFFFGTFVLCLWCVFAGEITFRIGSWINRNHIRRFRSNMVRMHNLSVKALLLKDKENYRACNKEANEAFGKYFFNMLTMGAAVLWPVPFALGWMNTRFGHIEFALLFPLPVLGQSVGFAAVLIPMYILCRIFWAQIKKKMPDTPAEPGLKPGETGQEEMISMHEVEKEGRIPERFWDSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STQ4</accession>
    <name>D6STQ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871419.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1409"/>
    <dbReference type="EnsemblBacteria" id="EFI34070">
        <property type="protein sequence ID" value="EFI34070"/>
        <property type="gene ID" value="Dthio_PD1409"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1650683at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="261" mass="30043" checksum="918FB6579B62BA68" modified="2010-08-10" version="1">MEAVAVGVCQTRVMRRVNDILPWLDLIERQQGPCLWVFPELFMGGFDYLQRDRCLEMNLEVRQIMSEFASRTENVLAGSFWEEKDGRIYNAFELFTPDGEKCSPYQKLHLFKPGKENMHFEPGRHAPQCFEWKGIKIGFGICHDLRYPELFLYQHEFEPDLFILTSQWPMARVEHWQALLKARAIENQCYVLGCNGTGASELGDLAGHSCLITSWGKTVFSLSKEVGLKKSGLQAEVILTDRRGFDSRRSDFFLVDFGGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6STV4</accession>
    <name>D6STV4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34120">
        <property type="protein sequence ID" value="EFI34120"/>
        <property type="gene ID" value="Dthio_PD1461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="7917" checksum="CAC734DAB73F5747" modified="2010-08-10" version="1">MQYSLHGFGYVADIVEYTLITALKIYGKTSEIKQGHLPTSYLNNTTTLPFQAKKNAGTIAGTSVKLIKIIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6STV7</accession>
    <name>D6STV7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871472.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1465"/>
    <dbReference type="EnsemblBacteria" id="EFI34123">
        <property type="protein sequence ID" value="EFI34123"/>
        <property type="gene ID" value="Dthio_PD1465"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="348"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="555" mass="62395" checksum="AC9E146BE379B3BF" modified="2010-08-10" version="1">MDIRLDRKEVSTALVFGLIFVLLGAGLFFLTWQNLRQQQEQVREHMALSAQSIGRGIEANLYRGAMRGMGGRRWADEQDFIPAAEDLLKELMQDGDVVFLGLYGPEGEEFYASRDILPVDFRPGPEMLEKASREVWNAELVLDGQQVFVQGFPSRRMGHMRGRMLQENDPGNGYGSLFIALDMSGHLEAYSGYKRTISVQAVFTFTALFIIGLLAWGYVRKKEQGRQFVRLSSFHSRLLDNMPDGLISVNSRMEITAANPAAQELLDQNRNIVGSSLSEVLPLEIDLEQRSGWHELEMGNRSIEVLILPIGEEEDFLVLLRDRTRMRELESSLEHSRRLAAVGRFAAGLAHEIRNPLSSLKGFAQYFQQKFSGEEPASEYARTMVSEADRLNRVINDLMYLARPRSLQRVELNLADLFQEVRTLLEMDLRSGSVQLILEPGEVEVKADRDLIKQAVLNLVLNSLQASRQGGEISLRATREKDRVRIEVQDRGCGMDAATREKALEPFFSAREKGSGLGLAIVHRIVQDHGGEIEIDSMEGKGTRVALLLPDTSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STW9</accession>
    <name>D6STW9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871484.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1477"/>
    <dbReference type="EnsemblBacteria" id="EFI34135">
        <property type="protein sequence ID" value="EFI34135"/>
        <property type="gene ID" value="Dthio_PD1477"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="351" mass="39383" checksum="07F35CFAC0421BB2" modified="2010-08-10" version="1">MPGNEPENFVVIRLGSLGDVVLTTGVLQAWHARTGARFIFVTKKAFAPVLEKHPAIKEIITVPGKYLTTPGWLNFCRLLARRFRDLQLIDLHCSLRSRILRAMWPCRTFAYPKMALHRRMFGLTGMDLFGRELLKSNIPQRYFRALYPRPPARDTLEPRIHLSSAEKAEARETLSRSGITLASQHTPSRPLIALHPYATHPAKAWPTDNWLALATLLEDRGMDWVIIGRENYSLLPDSSRDLTSRTDIRQTCALLEHCCALVTGDSGPMHLARAVHTPLVALFGPTTREWGFFPAAKNSLVLESELPCRPCSLHGRLKNTCTAPCMHHITPSRVLDALNRITSGSSTLNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU05</accession>
    <name>D6SU05_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871788.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0411"/>
    <dbReference type="EnsemblBacteria" id="EFI33096">
        <property type="protein sequence ID" value="EFI33096"/>
        <property type="gene ID" value="Dthio_PD0411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10076" checksum="4C87D8F5C662F3F3" modified="2010-08-10" version="1">MWKVEYRKRFLKELAGLPLHVQARAEKLVFEELHAGENPFELELLEHMKGYPGKYKIQIGQYRIGVSLKKMIDSLSVNELPMQGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU50</accession>
    <name>D6SU50_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871526.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0137"/>
    <dbReference type="EnsemblBacteria" id="EFI32830">
        <property type="protein sequence ID" value="EFI32830"/>
        <property type="gene ID" value="Dthio_PD0137"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08182">
        <property type="entry name" value="HEPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035873">
        <property type="entry name" value="PhpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="360" mass="39908" checksum="CDCAD4AAEBF2A8F3" modified="2010-08-10" version="1">MPDTWTHYHPVRIISGPGCIQKVASHLKGNPWLLLTSPGFTRRGTTDRLKALVSPHTLQVHDQVEPNPDLDHLDQLTRHYRQNMPRGILALGGGSVLDTAKVLSLTLPCSLDNPLHAVLRQGEEYSWNTSLEVIALPATAGTGAEVTPFATVWDRLNNKKHSISSELAYPELALLDPELTLSLPHKQTLYPGLDAVSHALESLWNKNATAISTAYAWQALSLALENLPDVLDDPGNLASRQNMQHASLLAGLAISRTKTAIAHSISYPLTSYYQVPHGLACSFTLPRLLDRHLESLADTPWKKELLQDLQAFLSGLDLDSHIEKYATQEQILSLQDHMLSKDRADNYIFHPTPLEQIIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU71</accession>
    <name>D6SU71_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0158"/>
    <dbReference type="EnsemblBacteria" id="EFI32851">
        <property type="protein sequence ID" value="EFI32851"/>
        <property type="gene ID" value="Dthio_PD0158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="115" mass="13249" checksum="845F2FB0D9967A64" modified="2010-08-10" version="1">MNSTDITTSNQDKLRQCLSEAFSKIDITQNNVASNSKKPDINPETYYHVRSRRIMTKMDFHLPFMDSSTLTEILQAAWRDSPELYSRAPELAELAHRMKSEIAPPRVLPAYVYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU84</accession>
    <name>D6SU84_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871558.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32864">
        <property type="protein sequence ID" value="EFI32864"/>
        <property type="gene ID" value="Dthio_PD0172"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1900592at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11717" checksum="CC5CF6D3021B777E" modified="2010-08-10" version="1">MSYTTTSINGISIRLTNERWGHIVEEHAELGEMMDFVLLTVSNPDIVLAGNSGEFLAVREFDTKKHLVVPYREINKDGFIITAFLTRRIQSLQRRKQIWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUE2</accession>
    <name>D6SUE2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0236</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871615.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0236"/>
    <dbReference type="EnsemblBacteria" id="EFI32922">
        <property type="protein sequence ID" value="EFI32922"/>
        <property type="gene ID" value="Dthio_PD0236"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="370"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="8">
        <location>
            <begin position="622"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="8">
        <location>
            <begin position="837"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="988"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="693"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI32922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123709" checksum="F4FEC96691127D43" modified="2010-08-10" version="1">MDDETLQMYVEESREHLEDIESDLLKIEEAGEDVDLDLVNKVFRAAHSMKGGAGFLGLINLKELAHKIENVLDMIRNMELTPNPEIVNIILLAFDRLREMVENIHESEDMDIAEHVTALTGITTSALDDDEKDTVIREVSINDHSGREIFRIPEYDFNQARKGGKFVYLLEFDLIHDVHQKDKKPLDLVKDMQSTGAILDLKVDLEAVGSLDDDSFSNKIPLFILFSSIIEPDIINSLFEVPSERIIQVQAQEIQEKPPAAEQPQDQEQIPEETVEEEPDSSYDLNLEGLEAEPGQDEDQQEEDKEEDKARETEVEPEPEAPPPPDPQGEKPAPPQAEQKEKSQARPQKTQPDKDKKPQDKQAAQAQTSSMPDSLRVNVGLLENLMNLAGELVLSRNQLMQAISTQDDQTINLAGQRIDLVTSELQEAIMLTRMQPVSNVFNKFPRVVRDMSQSLGKDIELYLEGKEVELDKTIIEGLSDPLTHLVRNSADHAIEKPDERVAKGKKPQGKIVLKAFHAAGQVNIEIIDDGKGIPVERIVEKALDKGLITEEQVRTMSDKDKAQLIFLPGLSTADQITDVSGRGVGMDVVKSNLDRLGGQVDIDTEEGKGTSIRIKLPLTLAIIPSLLISVSQERFAIPQINVDELIQIPAQQVQEKIEVVGDAQVLILRGELIPLVGLNEILRLDQKNTRSKARVTSIEEARSRKDRQDKKAETSAQTSEKSRSEDAGLEKEVIEASKWSISGEEDINIVVVYSGTFKYGLVVDELHDSVEIVVKPLGRHLKACDGYAGATIMGDGHVALILDVVGMARLAELSSMAGTEKAQEMAREQETEKEKDLHSLFLFNNGPREHCAVPLDLVARVELIKAEDIEITGGKKVIQYRGGVLPVFALHEAASVEHLELEGELVVIVFYMAGHEVGLLASPPVDAREVRVEIDDFTLKQNGISGSAVLEGYTTLIVDIYEFMETLNPQWFESREKVQSLEQEGGTQILLVEDSDFFRNQVKKFIQDEGYEVVAAEDGAVAWQYMQDNPGEVQLVVTDLEMPNMDGFELTEHIKSDDRFNHLPVLALTSLAGEEDVARGKKVGIDDYQIKLDKEKLLQSIFDFLNKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUH2</accession>
    <name>D6SUH2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraZ</name>
        <name evidence="10" type="ORF">Dthio_PD0266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0266"/>
    <dbReference type="EnsemblBacteria" id="EFI32952">
        <property type="protein sequence ID" value="EFI32952"/>
        <property type="gene ID" value="Dthio_PD0266"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI32952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="151" mass="17784" checksum="A2218E614261B2C2" modified="2010-08-10" version="1">MFRGHSQRSIDPKGRLMLPPEFRETILEHSPEGRVMLTNFDGCAVGYPLPEWERIEQSFNQLNMANRKFRDFHRFFISGATEISLDKQGRILVPPYLRSYAGMNREVVLAGVGRKFEIWDMERFEAQRRMMEQDFDGIMDSLAENGFELRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUJ9</accession>
    <name>D6SUJ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor</fullName>
            <ecNumber evidence="8">2.1.1.80</ecNumber>
            <ecNumber evidence="8">3.1.1.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="8"/>
    <dbReference type="EC" id="3.1.1.61" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871672.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0293"/>
    <dbReference type="EnsemblBacteria" id="EFI32979">
        <property type="protein sequence ID" value="EFI32979"/>
        <property type="gene ID" value="Dthio_PD0293"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CheR-type methyltransferase" evidence="7">
        <location>
            <begin position="214"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="934"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="651"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1128" mass="129224" checksum="0E83225E7BDDFC75" modified="2010-08-10" version="1">MPQELHDTQNQNTQEKSPGTPGLYVAVGASAGGLEAIEAFFADMSSSSGLAFIVIQHLSPDYKSLMKEILSKKTSMHVHRIEEGMEVLPDNIYLIPPKKNLTIFHGRLFLSEQEHTKGLINLPIDIFLRSLAEDQGEKAVSIILSGSGSDGMRGVRAIKEHGGMVMVQSEDSAKFDSMPRSAISTGLVDFVLPPEEMPGQLVSYAKHPYVAKAEKSDRVISDDDAMTKIFAILRDKYKVDFTHYKPSTLTRRIQRRMTINHISDIHDYVSYMQSYPNEAATLFREFLIGVTRFFRDREAFEALKDNWLQEVLSTRQNNEMRFWIPGCSTGEEAYTLAILARECMEQTGRMRDIKIFATDIDRNALQVAGAGSYPESIAADVPPDLLAKYFYKKKDSFQIARNIREMVVFAQHNLIKDPPFTNIDLISCRNLLIYLQTDLQRKVLEFFNFSLNMRGILFLGTSETTGEMGDYFESLDHKHKIYRTRGRVKNTLGARETLRSSDNVYHMNRERNALPGRNLRGREDLILERFLNVLEEEHIHLAVIVNDHMEVLHVIGNSEGYFKLPSGKQSMDISKMAANDLAIPISTGIQKVLRQNEPLHFSNIRVRYQGDHRMVDMRIKPLPQKKGQDPLVAVFLDESKKQQDKLACQDVDQTYDISREAEQRIHDLEQELQFTRENLQATIEELETANEELQATNEELLASNEELQSTNEELQSTNQELYSVNSEYQNKIIELTELHNDVDNLLSATQIGKLLLDENMEIRRFSPKVTNIFKLLDSDVGRPISHIAHYLQGLDPIEVIENVHKSGEMSEKEARTREGRWYLMRVVPYEVAPEVFSGTVTSFVDITRIKETEAALKTKEALLEQTQRLSRVGGWEMDAATGSITWTDEVYNIYGVSKDYNPSDVEKDMQFYTPEGRDRLQEAFKLALERGIPYDLELPFTKADGTRIWVRTSGLPEKKDGKVVRILGNIMDITQMKEIQQALRESEKYYRNLFSQMPNAFALHEIVLDHDEQPCDYTFLEVNPAFEEMTGLKARDILGRRVLEVLPETEESWIQRYARVALGGPPEDIQDYSLELQKYFKVRVFSPEYKKFAVIFDEIRDTSDISRALRDCEEKLKKLQENSSPGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUM5</accession>
    <name>D6SUM5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">Dthio_PD0319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871698.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0319"/>
    <dbReference type="EnsemblBacteria" id="EFI33005">
        <property type="protein sequence ID" value="EFI33005"/>
        <property type="gene ID" value="Dthio_PD0319"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="68" mass="8019" checksum="F1CEEE4C065F7EA2" modified="2010-08-10" version="1">MKPEEIRKLSRADMQEQLGGFRQELFNLRFQHSTGQLENTQRLSQVRKNIARILTILREKEAGKAHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUM6</accession>
    <name>D6SUM6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 9">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplP</name>
        <name evidence="12" type="ORF">Dthio_PD0320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871699.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0320"/>
    <dbReference type="EnsemblBacteria" id="EFI33006">
        <property type="protein sequence ID" value="EFI33006"/>
        <property type="gene ID" value="Dthio_PD0320"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 7 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="11">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="137" mass="15336" checksum="9CA67A4C653157FA" modified="2010-08-10" version="1">MLSPKKVRFRKRQKGKIKGKASRGTNVNFGEIGLKAVESGKITNQQIESARIAMMRHIKRGGKVFIRIFPDKPITAKPAETRQGKGKGSPIGWCAPVKPGRILYELRGVANTELAREALRRASYKLPVKTVIVEKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUX5</accession>
    <name>D6SUX5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871830.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0014"/>
    <dbReference type="EnsemblBacteria" id="EFI32731">
        <property type="protein sequence ID" value="EFI32731"/>
        <property type="gene ID" value="Dthio_PD0014"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="75" mass="8539" checksum="A20CA9A8B296E71A" modified="2010-08-10" version="1">MLVKVTSKNQITIPKKYADKLQGTKYLDVQYHDGALLLKPVQTYEADLETIRSKMEKLGLGAETVQDAINWSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJR1</accession>
    <name>D6SJR1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module antidote protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3566"/>
    <dbReference type="EnsemblBacteria" id="EFI36114">
        <property type="protein sequence ID" value="EFI36114"/>
        <property type="gene ID" value="Dthio_PD3566"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014057">
        <property type="entry name" value="HI1420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40275">
        <property type="entry name" value="PTHR40275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02684">
        <property type="entry name" value="dnstrm_HI1420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="12638" checksum="A425117D22300520" modified="2010-08-10" version="1">MTKLAKFDAAEYLDSEEVIAEYLNAALEDEDPSVFLTAVGDVAKARGMTDLAKDAGLGRESLYKALKSGAKPRYDTVLRVIRALGVDLQTVPLKKSISIHQDRGDQQAEVVRDTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJY2</accession>
    <name>D6SJY2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869307.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3641"/>
    <dbReference type="EnsemblBacteria" id="EFI36185">
        <property type="protein sequence ID" value="EFI36185"/>
        <property type="gene ID" value="Dthio_PD3641"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925328at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="714" mass="81277" checksum="6D0F06B07EA83228" modified="2010-08-10" version="1">MQTSDTLIKISPGVGKTHGALSILVPYADKKKILFLVPTGDVVNEAYEKARQTAINLGINPKHIRKIRGRTEGKEPLKPGWNHRPDATCYRMEEVREIARKGYAPGLNVCPECPHDKVCPYKKQFEDMPLQRIIIATHEVAKYLELVSHIVIIDENPVKAYYEEHVVSLESIQNLLPKIPLKSAETINKMIKSSQELLHQAVKCKQGEGRIYADPRSNWSHTEGLSSIANIPKEEWDLLDDHLSVFEKFENEKPIQHQRRLIEENITPLELEWMKIASGYMDGIAYIRADHRKEQGISFVYNKLCAPDFEKAKNIICQDATGIIEELQALLPRRSFKLVDAAVDLPGRKYHLKYALGKTAVVGDGNKCTPMKDQHIRSKLKKGIECLSKDEQHVLIITHMAAEERVLQLVKEIDPDREYQVTHFWGNRGINRFETCDAVICFGTPTANPEGLKDMASCLFNDVEKEDAWVADLGIRELVQSIHRIRPIYRPKSIIVMGQHWPESLGKPDFQAVQYNRGGSLDVALQRLRPILEKAGIVTREIACLAGVFCRQDSEHIHDWKRVRETLIEFVPFHIRDTLIGKGTNSKGDFVPVKLTKNSAWSDLINTLMLETGLPEIKCYYKDSPGKPSRGVGTISAARKFYHQVGLEFDAESWSGVEAMPSEFYEAKIQSYLAKIKNNVWPFKFNKPVNVQASYKSKKLAALEAVQRRLVHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJY4</accession>
    <name>D6SJY4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3643"/>
    <dbReference type="EnsemblBacteria" id="EFI36187">
        <property type="protein sequence ID" value="EFI36187"/>
        <property type="gene ID" value="Dthio_PD3643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8273" checksum="49901F84541E11ED" modified="2010-08-10" version="1">MSSIIKDAPGLIPRGIKKNVQQAGLTYFLSYIPARLHCQAHIQEIQDVAKISAEHQDIKSLQSTLLSARYPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJZ7</accession>
    <name>D6SJZ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869322.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3656"/>
    <dbReference type="EnsemblBacteria" id="EFI36200">
        <property type="protein sequence ID" value="EFI36200"/>
        <property type="gene ID" value="Dthio_PD3656"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1769431at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="234" mass="26413" checksum="704A94A908A9113D" modified="2010-08-10" version="1">MPLRTWITVFILLFLPLLLSGCSQSPVPVSHPYSLQKQMQAAKHWEIVAQDLGRDISEMLQEGNLQDPRVNVASNDISPFSQALESYLVTDLTRSGIRITSDTEDAYQLYWSVQSVTHKASRNFNRVPPGTGLLMGALGYGTYKLIKDGNAFAQSIGAGAGLETVFVADSIFQNRIPHNEIIINATVQKDKDIYYRLSNTYYIRDLDTDHYHFSRDLYQADADVETRTFNVKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK31</accession>
    <name>D6SK31_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3691"/>
    <dbReference type="EnsemblBacteria" id="EFI36234">
        <property type="protein sequence ID" value="EFI36234"/>
        <property type="gene ID" value="Dthio_PD3691"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="146" mass="16561" checksum="3C2C5005726771E0" modified="2010-08-10" version="1">MRSHHFKQVNTRGIMNNLITATKQFFDASSEDILLIFVFGSAAVNRLTSESDVDVALLFSCTPEYFQILKIKAELAAAVGREVDLVILNDSSPIIRMQVLKNGILLKKFSSAAYSEFVVRTVKEYDDLKRKRKEAEDRLLQGRIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK49</accession>
    <name>D6SK49_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transposase IS66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0027</name>
        <name evidence="7" type="ORF">Dthio_PD0741</name>
        <name evidence="8" type="ORF">Dthio_PD1751</name>
        <name evidence="9" type="ORF">Dthio_PD1887</name>
        <name evidence="10" type="ORF">Dthio_PD2647</name>
        <name evidence="11" type="ORF">Dthio_PD2684</name>
        <name evidence="12" type="ORF">Dthio_PD3000</name>
        <name evidence="13" type="ORF">Dthio_PD3712</name>
        <name evidence="14" type="ORF">Dthio_PD3833</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868370.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0027"/>
    <dbReference type="EnsemblBacteria" id="EFI32740">
        <property type="protein sequence ID" value="EFI32740"/>
        <property type="gene ID" value="Dthio_PD0027"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33409">
        <property type="protein sequence ID" value="EFI33409"/>
        <property type="gene ID" value="Dthio_PD0741"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34396">
        <property type="protein sequence ID" value="EFI34396"/>
        <property type="gene ID" value="Dthio_PD1751"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34521">
        <property type="protein sequence ID" value="EFI34521"/>
        <property type="gene ID" value="Dthio_PD1887"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35236">
        <property type="protein sequence ID" value="EFI35236"/>
        <property type="gene ID" value="Dthio_PD2647"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35272">
        <property type="protein sequence ID" value="EFI35272"/>
        <property type="gene ID" value="Dthio_PD2684"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35574">
        <property type="protein sequence ID" value="EFI35574"/>
        <property type="gene ID" value="Dthio_PD3000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36252">
        <property type="protein sequence ID" value="EFI36252"/>
        <property type="gene ID" value="Dthio_PD3712"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36363">
        <property type="protein sequence ID" value="EFI36363"/>
        <property type="gene ID" value="Dthio_PD3833"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="768876at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039552">
        <property type="entry name" value="IS66_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024463">
        <property type="entry name" value="Transposase_TnpC_homeodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024474">
        <property type="entry name" value="Znf_dom_IS66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13817">
        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13007">
        <property type="entry name" value="LZ_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13005">
        <property type="entry name" value="zf-IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LZ_Tnp_IS66" evidence="4">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="zf-IS66" evidence="3">
        <location>
            <begin position="108"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="173"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="5">
        <location>
            <begin position="467"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI32740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI36252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI36363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="518" mass="58863" checksum="37453B4A08868987" modified="2010-08-10" version="1">MDINNLPDDKDALKDIVADYHQQLIYLQEKLNFLQKAIYGSKSDKKPKCGSKETWPMMPGLVEMETEVETPQEKTITIPEHSRKKRGRKPIPKDLPRKDIIHDLSGEEKICPCGVELSPIGQEVSEKLDYIPARLIVNRYIRLKYACKNCEGAEDDQGAVKIAPMPEQLIPQGIVTPGLMAHIITAKFVDGLPFYRQCKQLLRLGIDISRSTMVSWAMHAARVCEPFLDLFKKEIMLGFQVGIDETPVQVLDEPGRSNTSKSYMWVFLGGHPENPTVLYDYHPTRSGLALDFLQDYQGYIQSDGYAVYNDLGDKPGIFHVGCLAHVRRKFMDVVKLSKKQKHKGGTAQEILNLIAKLYILEQSFETRKLKPDRIQEERQEKSIPILNQIKTLLDERSKTTPDKSKLGTAINYALNQWDRVVRYTLDGRLRPDNNLVENAIRPFALGRKNWLFAGHPNGAKAGAMYFSLVETAKKNGLEPYAYLRHLFENLPLAKTEQDLKALMPQYIDPEVLPSPTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK76</accession>
    <name>D6SK76_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein Dthio_PD3742</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869398.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3742"/>
    <dbReference type="EnsemblBacteria" id="EFI36279">
        <property type="protein sequence ID" value="EFI36279"/>
        <property type="gene ID" value="Dthio_PD3742"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="170146at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="906" mass="103884" checksum="23592E0D0622359E" modified="2010-08-10" version="1">MSNMFGPNDPRWQGPQFRLEDLDFSRIYKLAKVGLAVVAFILVLSGIGWAQSFYTDWLWFSSLGYQQIILKILYTSVGMFFLGAAVFLALALPNIYLAHKNITSLRLINQNVPMQLYYKARTLVFWGAFCAAGLGAVVLARSFASQWEKALLFMHQVPFEESDPIFGNDLGFYVFSMPMLDFVRSWLLVAVIFVLIIVAAYYFLNSLLRGEQFSFTGRVRTHLALLGAGVLLIMALGHWLGRYDLLNSTMGAVYGIGFTEDKVLRPGLAIMTFVALAAAGVLAAAPFYRGRQLMVVALAAWFGLNIVLVHLAPGLVQRFMVEPSELARERDYLEHNINFTRQAYGLDNIASQRHPARGEMDRQTIEDNEGTVRNVRLWDEGPLLQSYNQIQFFRLYYDFLQVHTDRYNVDDELRQVMLATRELSADKLPSEAQRWVNRRLQFTHGYGVAMTPVTEVESGGRPGFFIRDVPPTGKVNLDRPEIYYGLKSLDYLIVRSRMQEFNYPGPEGPVYTHYEGEGGVKLDSFFRRLMYAWKFSDINILISNEVTRESLIQYRRTIPERFSVLTPFLQRDREAYSVVADGKVYWIQDAYTVTSRYPYSAPWQRAFNYMRNSVKTVADAYHGHMDYYISDPDDPVVRTYDAVFPDLFKPLEEMPEYLRDHVRYPLDLFTVQSQKLLEYHMQDPVVFYNKEDQWSVPVQHSFGQTEVLQPYYIVARLPGEEKEEFLLIQPFTPVDRHNLVGWLAARSDGENLGEMVLYNFPSGRHVDGPNQVEARIDNDAIISEQFTLWGQVGSEVSRGILLVIPVGDSLLYAEPVFLKPDTLDFPELRRIILADSEQVVMHQILDDSIDALVGELPAVAPVVETDEELPVREDREDRVLPEFREGLREAVDSLQEVLDGLKEMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK79</accession>
    <name>D6SK79_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869401.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3745"/>
    <dbReference type="EnsemblBacteria" id="EFI36282">
        <property type="protein sequence ID" value="EFI36282"/>
        <property type="gene ID" value="Dthio_PD3745"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="10"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="450"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI36282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="526" mass="58527" checksum="3DB64EB453C39F52" modified="2010-08-10" version="1">MSDTTLETRVLIIGSGIAGCTAALHLARKGRDVLLVCSGLSMDDGNSALAQGGIVYKAPEDTPDLMENDILTAGWNYNHLQAVRYLCLRGPEVVQKILIEDLQVPFDSLNGSFHLTREGGHSLARVLHCADYTGRAIMDAYIKAVKKEPNIKVLTGHTAVDLLTTHHHCTRKEIRYHLNNRCMGAYVLEQATGNVLKVLADYTILASGGMGQIYLNTTNCRLSLGSAVSMGHRAGARMMNLEFIQFHPTALFHRGPRKFLITEALRGEGAFLVNARGEPFMHKYDSRKDLAPRDIVTRAIVDEMLATHEDMVFLDAATHIQNPDKRFPTIHKKCLELGIDIRDQLIPVVPAAHYFCGGILVDTTGRTTIERLFAAGECACTGVHGANRLASTSLLEALLWGQTIAETIASRLGARSRLSQKTKASVPDWKFLGNKQNEDPVLIAQDWATIKNTMWNYVGINRTRPRLQRGFEDMRNLNKRLHDFYRETPISQPLVELFHGCYSAYLITTAALRNKQSLGCHQRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKA3</accession>
    <name>D6SKA3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869425.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3770"/>
    <dbReference type="EnsemblBacteria" id="EFI36306">
        <property type="protein sequence ID" value="EFI36306"/>
        <property type="gene ID" value="Dthio_PD3770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12869">
        <property type="entry name" value="MqsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038493">
        <property type="entry name" value="MqsR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031451">
        <property type="entry name" value="MqsR_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15723">
        <property type="entry name" value="MqsR_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="107" mass="12736" checksum="CB2E8DDCDB59B077" modified="2010-08-10" version="1">MAKWKPHYDLKKSKSLIDSDKYIIVKSAKTTAFKLNFNEQRIKDVLLNIKPSDFSKSEEDWQIKGHWQDAYKTCYDGHRLYVKWKITENKEEHLLVLSFKEDQGGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKJ5</accession>
    <name>D6SKJ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868340.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2614"/>
    <dbReference type="EnsemblBacteria" id="EFI35206">
        <property type="protein sequence ID" value="EFI35206"/>
        <property type="gene ID" value="Dthio_PD2614"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZQN3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1954291at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8913" checksum="488C9F93FEB9EEF4" modified="2010-08-10" version="1">MNCAACNSHMVHKQGEIELRIGGKLFLEKNVSYQQCEECGERVLTPDVSQEIFNKITKKDYKEKQIIVPVIESNTASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKR3</accession>
    <name>D6SKR3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868406.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2686"/>
    <dbReference type="EnsemblBacteria" id="EFI35274">
        <property type="protein sequence ID" value="EFI35274"/>
        <property type="gene ID" value="Dthio_PD2686"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanZ" evidence="1">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="123" mass="13735" checksum="79A517041F9AB8FF" modified="2010-08-10" version="1">MVVPVLYMGLILVGASIPADNGEAGSHRLHFLLLPSLLQNLIHIPAYGLLAFLWRWCLDAYVQARTAVVLALFLTIGFGIFQEWYQITVPGRYASISDIVFDAIGAVLGVWLFKRLKNKFCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKR7</accession>
    <name>D6SKR7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2691"/>
    <dbReference type="EnsemblBacteria" id="EFI35278">
        <property type="protein sequence ID" value="EFI35278"/>
        <property type="gene ID" value="Dthio_PD2691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14066" checksum="111B96C24BF3A096" modified="2010-08-10" version="1">MEKMTGSPTVTTVSRVLLVVVLVFMPYATLAPGTSPPSDAASQMHFYIMAGIIFVACMSFRTFRVRLVVGLLVFGYSALMEYFQYLLPHRHGSLDDVAINFLGSLLGFGVFHAVCWTGQMARSIRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKT9</accession>
    <name>D6SKT9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferase hexapeptide repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2714"/>
    <dbReference type="EnsemblBacteria" id="EFI35300">
        <property type="protein sequence ID" value="EFI35300"/>
        <property type="gene ID" value="Dthio_PD2714"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="230" mass="25721" checksum="8885255FDCC9FFEF" modified="2010-08-10" version="1">MSCLKQTVNVNKAELMKNYIKKIFAMLGILLFKVQGQIEDRTLPTFATYPKRLKINLPRNIANPQHIYIGDNVKFGPGCFLLALTEYPTSKMRNSEFNKATQKFNPVIKIGDNVTATAYVQISALERITIEDDVMFASNVFVGDHQHGYQSAATPYKYQPIWKINPITIKKGCWIGQNVIVMPGVTIGECSIIGANSLVNKDIPPKCIAVGSPATVIKKWDDQSQIWIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKU7</accession>
    <name>D6SKU7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868440.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2723"/>
    <dbReference type="EnsemblBacteria" id="EFI35308">
        <property type="protein sequence ID" value="EFI35308"/>
        <property type="gene ID" value="Dthio_PD2723"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="99"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="218"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="399" mass="45016" checksum="A0E9C33AC6701AF1" modified="2010-08-10" version="1">MKRILYLKAGNAVQEYKVLIDSGLNKAGGSESFLADFLKLVGDNPSLVISLHTVDNHDQKIVGKTLSIHSYSRLAWDWFVAGKRAGRFLRLIKNSCLIFIRVLRFKPDAVLCWSGSLPCWACFVGARLTKSKFIFSRHITFTTDDMSKLKRFMGVMDRLILNRADAVIAHGPFLLEESIKDGVPPERITMFDCVFDEKSVWYKKKLYPGSSIRTMLSTKRFNILYVGRIEAAKGIFDLLTAFTGIMEKHSRTMLYYVGDGNHLPALKKEISSRRMNSRAKCLGRIAHDRLPKLMNIGHCLVVPTRIEYPEGRCMAAMEGLIAGLPVVAPDFGPFPYLIKDRGNGLLFKPDSPKSLKDCLTRLLEDKDLYGQIRLGAAESGRKLLENRNGYFITLKKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKV8</accession>
    <name>D6SKV8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2734"/>
    <dbReference type="EnsemblBacteria" id="EFI35319">
        <property type="protein sequence ID" value="EFI35319"/>
        <property type="gene ID" value="Dthio_PD2734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="11212" checksum="54B194417D9CC83C" modified="2010-08-10" version="1">MQRICLKKSQMPANKDVQYWQVASKNIQPINKFSPKEAGNLSRKLRLFSGKNHVHMNIKPLTLAFSFSCFALRCRNRFGPVVIHKKALQKTRVLCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL05</accession>
    <name>D6SL05_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868498.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2781"/>
    <dbReference type="EnsemblBacteria" id="EFI35366">
        <property type="protein sequence ID" value="EFI35366"/>
        <property type="gene ID" value="Dthio_PD2781"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="109"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="475" mass="54709" checksum="BFA515CD4DD1F892" modified="2010-08-10" version="1">MKKNIFVIGLDDFNLGMISSVKNAEGYNFIGLLDIHALIDSGLYRLSDMLELAEQQLREFKGTIDAIVGYTDFPVSTMVPILCEKFNVPGPSLESVLKCEHKYWSRLEQKKAIPEHIPAFTEFDPFDDQALDRISLEYPFWIKPIKSTASQLGFRINSRKDFKRAVAVIREKIGLFKPFDYLLDMVKLPPEVVRVKSSHCVAEQIISGHQCTLEGYVHNKEVLTYGIIDSIREPNRTTFARYQYPSRLPRKVQEEMSRISERVIKQVDLDHSAFNLEFFWNEKKDKIWFLEINTRIPQSHSDLFVKVDGVSNHQIMLDVALNRDPAFPRRQGRFRVAGKFFLREYQDKLITGIPTREDLEDLSNRIPGTLVDVQGKVGMKLSDIPEQDSYSYASAFIYLGADSQKDLLEKFRKCREMIRFQYQDLTIPTVSPKKIQEQAPETEPRVAIQVLTSPMELPVQEDTPMAGGVQDMTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL42</accession>
    <name>D6SL42_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CGGC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868535.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2819"/>
    <dbReference type="EnsemblBacteria" id="EFI35403">
        <property type="protein sequence ID" value="EFI35403"/>
        <property type="gene ID" value="Dthio_PD2819"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1563476at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014925">
        <property type="entry name" value="CGGC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08821">
        <property type="entry name" value="CGGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01078">
        <property type="entry name" value="CGGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CGGC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="126" mass="13937" checksum="024453CDDD282015" modified="2010-08-10" version="1">MKKIALIACSMIRGSNLCPGDAKCFVALGRKEGEFKRYENQDVSLVGIVDCGGCEGNKNRVVCSMALLNMHLKALNEKVDTIHVSTCIMKYCKRKDDLIEAIRQKAGVEVVEGTHDYIPPSIFEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL93</accession>
    <name>D6SL93_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868586.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2874"/>
    <dbReference type="EnsemblBacteria" id="EFI35454">
        <property type="protein sequence ID" value="EFI35454"/>
        <property type="gene ID" value="Dthio_PD2874"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="262"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="367"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="456" mass="50352" checksum="37FEB7C1A53A2A4B" modified="2010-08-10" version="1">MFLERIENPGLAQFSYIVGSEGVFAVVDPRRDCQVYLDIVRSQGGRITHIFETHRNEDFVVGSRELAEITGAGIYHGEELDFAYGLPAREGDEFHLGQVRLKVLKTPGHTPESISLVIHDLSTGDAPIGVFTGDALFIGGSGRTDFYPGQEEEMAGQLYDSIFSRLLTLGDQTVVYPAHGAGSACGEGLAERKFSTLGYERLCNPDLQAQSREAFIQAKQGEEHSYPPYFSRMEKYNLDGPPAIVPFNSLQPMGAEDFGQAMQEGMLALDVRSPEAYCGAFIPGSLSVPLDMLPRYAGWFVPLDQEVGLIAESHRDLDSAWEYLLRLGFDRVRGWLEGGLHEWSVQGKRYEHAPVVFAGELQKRLSSGEDFTILDVRTRKEFHKAHLPGAQHIFLGELPQRMQEIGPGRPVTAFCGSGKRAVIAVSLLRQHGIREVENCLGSIQACSRSLCEIVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLH6</accession>
    <name>D6SLH6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">17 kDa surface antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868669.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2961"/>
    <dbReference type="EnsemblBacteria" id="EFI35537">
        <property type="protein sequence ID" value="EFI35537"/>
        <property type="gene ID" value="Dthio_PD2961"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1912068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027367">
        <property type="entry name" value="Gly-zipper_YMGG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13441">
        <property type="entry name" value="Gly-zipper_YMGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gly-zipper_YMGG" evidence="2">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="214" mass="23186" checksum="79D3E49408470AFA" modified="2010-08-10" version="1">MKGSRAIILLVFMAVILSGCITGSDQRRTKAEGTAVGAAAGGLAGYLIGDGRGALIGAAAGAGLGYLVGREVAKRKAEYATQEEFLEAEAARTAEYNETMREYNDRSRQELAALEEEVESLRQAYEEGAEEKDTLLARQAEVQKRIQENEELEEELKSELAIQTAIIEEERQSLPEDDPRIAALEKEVQELQANIAALGEGSAQLASIDERLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLH8</accession>
    <name>D6SLH8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868671.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2963"/>
    <dbReference type="EnsemblBacteria" id="EFI35539">
        <property type="protein sequence ID" value="EFI35539"/>
        <property type="gene ID" value="Dthio_PD2963"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="549205at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="508"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="610" mass="66400" checksum="D6E3D3BAB56CFC82" modified="2010-08-10" version="1">MSSDKNYPLKVVPRLAASSLVHDRILTLCLIIALAAVIAPLLILLGLKHGTIETLRDRLVEDPVYREVRPAQIYEFSPEWFEQVGSWPGVEFIVPSVLPLSSIVHVEHPHTGRLEMFDLISSGPGDPLLLENGAPAPEDGQCVITHEAARVLGLEQGDVLEARVTRSRGGRREMAATGLEVAGVLPPRAGSLPRIYAPLSFVVDIEAYKEGYGVPTRGWEGDTPEPYLSYDGVLLLMPDPMDPIERTGLIINTGFAGINKAEHSQVTEKTAVPLPEEWTAYSLSTPGSPATMSWIRALRQKLRGKEHILLPYVSGVVLQDAAGREISPAGLSISRREALLLGVDYPPWGGFTGSAAPADRLTRVLLPEDFDSGLEMVFHGVLQLDIELQKAGTTDLQRLLVPAELMGVLRTASQRGVKLESESGEFAMVRGGFRGFRLYTESIDDVPGVYRKLQEEDMEVLAQVETIQRIQVLDAGLTRLYSLLALLGISGGTAVLLSSLYAAVERLRRDLGVLRLVGLGRRHVFFLPMVQGLMIAAAGLMLGFACYYTLAAMINHTFASELAPGERFCSLPLSYKGGIVFLTTCLALAGSLVAAWRATRIDPAEVIRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLJ0</accession>
    <name>D6SLJ0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2281 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868683.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35551">
        <property type="protein sequence ID" value="EFI35551"/>
        <property type="gene ID" value="Dthio_PD2976"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033I5F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2075077at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018739">
        <property type="entry name" value="DUF2281"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10047">
        <property type="entry name" value="DUF2281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2281" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="64" mass="7567" checksum="F467928F1CA8E46E" modified="2010-08-10" version="1">MNTTEVVINEIKQLPEPLQREVLNYARFLKHKAEQDSLLKAQLISMEQIWSNEEDEAWNNVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLU4</accession>
    <name>D6SLU4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">Dthio_PD3084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3084"/>
    <dbReference type="EnsemblBacteria" id="EFI35655">
        <property type="protein sequence ID" value="EFI35655"/>
        <property type="gene ID" value="Dthio_PD3084"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="165" mass="18718" checksum="641D2E1C821685ED" modified="2010-08-10" version="1">MAKDKLTAVYPGTFDPLTNGHVSLVKRGLDIFDEIVVAVALHSPKNPLFSLQERVDMVQKAFEPFPGVVGEPFEGLLIDYVRRKNAKAILRGMRAVADFEYEFQMALMNRRLDRGIQTIFLMTDYKWLYISSTLIKDVARLGGDITGLVPENVRLELLKKCRNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLX6</accession>
    <name>D6SLX6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase NPD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868816.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3116"/>
    <dbReference type="EnsemblBacteria" id="EFI35687">
        <property type="protein sequence ID" value="EFI35687"/>
        <property type="gene ID" value="Dthio_PD3116"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="14"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="358" mass="39063" checksum="3813C5AAE9A3EEA2" modified="2010-08-10" version="1">MDFPELRFKDLVARVPIIQGGMGVGISLSGLSSAVASQGGIGVISAAMIGMNEPDIAKKPEEANIRALQKEIRKARENSSGILGVNIMVALSNFAELVKTSIKEGVDIIFAGAGLPFDLPQYQTPESRTKLVPIISSARAARIMCKKWLSRFNYLPDGLVVEGPLAGGHLGFKKEQLDLPEFKLENLVQEVVAEVRPFEEEHGQTIPVIAAGGIYSGEDICRFLRLGASGVQLGTRFVATHECDADMAFKQSFIDCTEEDLMIIKSPVGMPGRAVRNEFLEDVEQGGRQPFKCVYHCIVTCDYKKTPYCIASALANAKKGKLHRGFAFAGQTAHRIKELTSVEELINSLRREYVEACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLY6</accession>
    <name>D6SLY6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipase D/Transphosphatidylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3126"/>
    <dbReference type="EnsemblBacteria" id="EFI35697">
        <property type="protein sequence ID" value="EFI35697"/>
        <property type="gene ID" value="Dthio_PD3126"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="476" mass="53308" checksum="76B57372C3737D8E" modified="2010-08-10" version="1">MLAESMIWSLGGWVIRLGMIPVIGMRQENPSTCLAWLAVIFLMPWPGLILYLLLEEHGLSRPRLSRRIKKHKNFHLTNSSYLTTPNFEGCQVNPDHQALVHLAEKHGGLPLLGSNRMKLIVDTEEFIDSLSADILQARNHVHLLFYIFRDDFTGRKVARALGEAAGRGVTCRVLADAVGSAGMFSGLGRWMQEQGVQVQNALPANPLRMRLARLDIRNHRKLAVIDGKVGYTGSQNIVDPEFGHKKAGQWHDVMTRVQGPTVRQLQSVFVEDWFYETQEILDDPDVYPPSTSEGMAAVQVVPTGPDRPTYGFQDLLIQAINSAQLSVSVVSPYFIPNEGLITALRLASARGVEVDIIIPDRSDHLLVDQASAYYCGIVLNNGGNVHLFRDGMLHAKIIAMDHSLAIVGSANFDIRSFYLNMELVSIVFDQQFSYELSLLVEGYKKNSFKVGRAWWSRRPVYKRMTEGVVKIFSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM08</accession>
    <name>D6SM08_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868848.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3148"/>
    <dbReference type="EnsemblBacteria" id="EFI35719">
        <property type="protein sequence ID" value="EFI35719"/>
        <property type="gene ID" value="Dthio_PD3148"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087981" evidence="1">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="312" mass="36616" checksum="FE978CAE2BDFDD1D" modified="2010-08-10" version="1">MRHCFFVTALVFLAVLAWGCSPDSPEEGVVATVNGQPIYLDEVESGYDADYFKWSRGVPPDLKEIKSSYGRVLLDLVVQKLIEQELNSSGHAVDPGEVAKIEREIRQDYPDGGFEEVLIEEHIDLEFWRASILKDLMWDKFKKEVLRPRISLDVEDVKEYYHYHIEDFYIPERIVFLHLSSGKEDKLQEVLDTFQESEDISRIREKYPQVNVGEYEMRVDRLPLGLQDELTGLQKGEKSQIQKNRQGLYYRVMVMDRKDSKLLKPHQVYDIIEENLVQEKMHKVFYNWLETTVDESDIKINARLLETAFMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM38</accession>
    <name>D6SM38_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868878.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3178"/>
    <dbReference type="EnsemblBacteria" id="EFI35749">
        <property type="protein sequence ID" value="EFI35749"/>
        <property type="gene ID" value="Dthio_PD3178"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="366" mass="40856" checksum="711020BC8418514B" modified="2010-08-10" version="1">MEQGARILVVDDDANIVQLIADIFEDEHEVLFALNGESAGRIADTTRPDLVLMDVVMPGMDGFETCARFKENQKTAHIPIIFLTSMDCPDDETRGLKLGAVDYITKPINPAVLKQRVRTHLDLYQARQRLAAQNKSLMEAARMRDEVEHIMRHDLKSPLTAMTGLPDILLMDDNLTTEQRETLQLMNEQGRRMLDMINMSLTLLKIEYGDYEPVLEKLDILALLRNTTSELSQLAKQYGVSCRLLVNGNQPDSQDQVNILSEDLLCRSIFDNIYKNAIEASPRGQVVSISIFTGPRTCVYIENKGEVPQDIRDNFFDKFVTQGKVGGTGLGSYSSRLAARALQGDIELDTSTPGQTTICVFLPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMA8</accession>
    <name>D6SMA8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35819">
        <property type="protein sequence ID" value="EFI35819"/>
        <property type="gene ID" value="Dthio_PD3254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="52" mass="5512" checksum="12ECCBF6BABDAEC7" modified="2010-08-10" version="1">MKTVSFLFALMLCGMLIFGFMGCNAERSAAPTDSPAPVKPAPELPEPVDPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMF2</accession>
    <name>D6SMF2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ORF">Dthio_PD3302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868992.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3302"/>
    <dbReference type="EnsemblBacteria" id="EFI35863">
        <property type="protein sequence ID" value="EFI35863"/>
        <property type="gene ID" value="Dthio_PD3302"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="353"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="265"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="485" mass="56111" checksum="7DD7A24B94FCF959" modified="2010-08-10" version="1">MLIYNTLHRAKEKFVPLEPGKVRMYVCGITAYDYCHIGHARSCVVFDVLVRYLRYLGYHVSFVRNFTDVDDKIIKRAEEEGLDSDQVAEKYIEAFYLDMDELNVLKADVEPRATRHIEEMIQVTKSLLDKGFAYITSGKDIYFRVRRMPRYGQLSGRNIEELQSGSRIAPDEEKEDPLDFALWKTAKPGEPSWDSPWGAGRPGWHLECTAMSEKYLGIPFDIHGGGQDLAFPHHENEKAQSEAAFDREFVKYWVHNGFVRVDSEKMSKSLGNFITIRDIMKDFHGEVLRFFLLTKHYRSPLDYSDGSLEETEKALKRVYWAKTGLQKELQKEKWSKGQGFPEASQELQDLASKWDQAMQDDLNTAEAVGYVFGLVRLANRMLEDKTFRKSEAGKEIIQQMLGMLEGWGDALGVFQRSGEEFLEQLKLMRCNRLDIDPQTVQEMVLKRQQARKDKDFETADNIREELTAKGIEVMDTPEGPRWDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMF6</accession>
    <name>D6SMF6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="2">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + H2O = adenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.2.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3306"/>
    <dbReference type="EnsemblBacteria" id="EFI35867">
        <property type="protein sequence ID" value="EFI35867"/>
        <property type="gene ID" value="Dthio_PD3306"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="239" mass="27201" checksum="8AF6765954CAB41A" modified="2010-08-10" version="1">MANSRQYLIEDLSYTNSWRLFKIMAEFVDAFEKMNDLGPAVSIFGSARLNPDDEYYRMAYDISNSLSRSGFNIITGGGPGIMEAGNKGAYDAQGNSVGLHIKLPFEQKANDYINLRCDFRYFFVRKVMFIKYAKAYVVMPGGLGTMDELLETLVLMQTRRIKPFPVILVGRDFWDGLLNWMTEQMVSRGYMKKSDFSLFCMADTADEVVDLIKNKVDLHSFQKNGVACQKTDTSQEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMG1</accession>
    <name>D6SMG1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869001.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3311"/>
    <dbReference type="EnsemblBacteria" id="EFI35872">
        <property type="protein sequence ID" value="EFI35872"/>
        <property type="gene ID" value="Dthio_PD3311"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="12">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="221"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="353" mass="38952" checksum="A65A9D64306A7971" modified="2010-08-10" version="1">MPSGNTFQINGQDLPFQEGMTILDAARMHNIFIPTMCHLPGAPPTGACRLCVVEVQGARNLAASCVTPAQRDMQINTESPRVVNSRRLNLQLLLAMGEHDCLLCPSSGQCVLQDLAYRYQINPKRFTPRGVLHRTEAVNPFILRDFSKCVLCGRCVQACCDIQVNNAISHAYRGIKSKIAAAGDRPLKESDCVFCGECMQACPVGSIIPVDSRQSPRIWETHKVKTTCGYCGVGCQMYLHHRDGVLYRVEGDIQSPPNYGSLCVKGRFGFGFVNSSSRLQTPLIRENGNLRPTGWEEALDLVHERLENIRMSHGPDALGLFASARTTNEDSYVAQKFARAVLGTNNIDHCARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMS0</accession>
    <name>D6SMS0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869109.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3423"/>
    <dbReference type="EnsemblBacteria" id="EFI35981">
        <property type="protein sequence ID" value="EFI35981"/>
        <property type="gene ID" value="Dthio_PD3423"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413095at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="156"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="464" mass="53043" checksum="AFE4DF57F1C29877" modified="2010-08-10" version="1">MFSDQEDVLFSDLHLKEDVLYFFYVGEIKADCLNQFVAETLGKIHGRKFECISIVPDIMESYPHRNIMVINPLAKNLYNQTSRKYSCRMGAKEFACEVSRSAAVRRLAEMLIARQGRLYIHVYESLPQLELCQLPGTVLLGPEGSISSIWNNKLYQLQMLSGQVPLMDYRICKNVRELYAGVESVAQEWSEGIFVSRPYSAAGANSFIIRSAPELEDQEPLSRDTYFISRYVPHELDPTVLGVVGNEDDVFIAAIADQEIENKNSFRGSAFPSSLSHKEQAEVREHARMVGRVLGRSGYRGIFGCDFIVDNQGRIFFVEVNARKQGTTMEMCCTLENALPPGAPSLMEMEYHAVVHNRLPPGRQEIKEAIQGLFWRTYNFKVEREVVTNYFLPMDEDERELFRQVRQKGLEHRMIIVEHPGHKRCVMPGSFLGRIVAVATNREDLDRDISLGKFMLEESITIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMT2</accession>
    <name>D6SMT2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869121.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3435"/>
    <dbReference type="EnsemblBacteria" id="EFI35993">
        <property type="protein sequence ID" value="EFI35993"/>
        <property type="gene ID" value="Dthio_PD3435"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738458at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="171" mass="18927" checksum="FD3169E6D2531397" modified="2010-08-10" version="1">MNERQGIVTLHQNPMTLVGEEPVKDRMAPDFEVVDNDLNPFKSSSIKGRVVIIASVPSLDTPVCDMEVRRFNQEAASLHDDISILTISMDLPFAQKRWCAAAGVDKVQTLSDHRDASFGKAYGVLIKELRLLARAMFVVDREGVLKYIQVVPEVSGEPNYKAVLDAASELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMX6</accession>
    <name>D6SMX6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869165.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3479"/>
    <dbReference type="EnsemblBacteria" id="EFI36037">
        <property type="protein sequence ID" value="EFI36037"/>
        <property type="gene ID" value="Dthio_PD3479"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="296" mass="34162" checksum="395E194168E61D49" modified="2010-08-10" version="1">MNSTPFKDYYQVLGVSPEASQDEIKKAYRKLAFEYHPDRNTEQREQAENKFKEITEAYGILVDPQKRKEHDKLRRYGGDYNFQQREQAGQDFTADPFEQIFRDLFNNPETSRIFREMEREFARHGVRFDREFMNNMFFPGGGSGRFTGGVFIFTSGGARRHQTFGGNGPRLGDEGRYLDLDRAKPPKSKEGFFKKLSRKVRDIFLESGKKAPEQNSLEQKQEKDLCYNVTIAPEEARLGTELNLAYTRGDRRVKLEVKVPPSTREGTVLRVRGKGLEGSPGEQPGDLYLRVHISKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMZ5</accession>
    <name>D6SMZ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869184.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36056">
        <property type="protein sequence ID" value="EFI36056"/>
        <property type="gene ID" value="Dthio_PD3500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZK37">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063386at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="153" mass="16929" checksum="5D5732893E9FEB09" modified="2010-08-10" version="1">MGEFQEVVKSIVALLNELADTGGVTSQKIPEIIGSTLEENRVIEGDARNAFNCYPGIPGHGCKDLAFFVSLTSPGFYKGRGHLNCGQAMEKIVQHMQGSCQGSTRHAIFLTDSWDAYAYNEWQANLSQIRQKALLEVYLITEKSVSLISLPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN22</accession>
    <name>D6SN22_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869211.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36083">
        <property type="protein sequence ID" value="EFI36083"/>
        <property type="gene ID" value="Dthio_PD3530"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2128823at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="183" mass="21254" checksum="A52691DB3BDA9283" modified="2010-08-10" version="1">MCGICLELHLMDLLEREYRTKAPVSQEDLEEVLLEPYAQESNFLMHCLKYARAFDMEDNVLSVVHCRALEEIALRPETAMQDSLAMIALIKHYHAFKRFIASRTISDKVLKWLPAPSWHNLYSPGFIFAKDKWGQFLGDKDLLVQCNGLLERYHSWWLLGKGQQKNDLSRKLRETVSAGLKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN23</accession>
    <name>D6SN23_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36084">
        <property type="protein sequence ID" value="EFI36084"/>
        <property type="gene ID" value="Dthio_PD3531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8995" checksum="2544D2F9FC79D90D" modified="2010-08-10" version="1">MFVALAYNLEEQVCTLLVYGQVAKLIQNEQFRTYIFLELCFELVCSLCGREGVYDIYGGGKQYRILFQACTVTQGCGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN43</accession>
    <name>D6SN43_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1517"/>
    <dbReference type="EnsemblBacteria" id="EFI34169">
        <property type="protein sequence ID" value="EFI34169"/>
        <property type="gene ID" value="Dthio_PD1517"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="36065" checksum="DDD4D9577B2A7085" modified="2010-08-10" version="1">MPRNARFTLPHRPTVYHVISRTALPGLPLGDIEKNRLLEIIKYFSSIYFVEVLGFCIMGNHWHLAVKIYPRDYATRQEVQERFVKRYGEDVHFGDQEMEKFSKKWTDLSEFVREIKQTFSRYYNKRHNRRGFFWGERFKSMIVQEGSTLVNMLAYIDLNPIRAGIVKKPEDYRWSSLGYHTQTGNKDGFLSIDFGLKEWNEQDPKEIVRKYRQFVYETGAVDAGKGKTIDQKVVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDERKFTPVGGVEGLYSMKRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN59</accession>
    <name>D6SN59_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0455</name>
        <name evidence="8" type="ORF">Dthio_PD0487</name>
        <name evidence="9" type="ORF">Dthio_PD1534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869515.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0455"/>
    <dbReference type="EnsemblBacteria" id="EFI33137">
        <property type="protein sequence ID" value="EFI33137"/>
        <property type="gene ID" value="Dthio_PD0455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33164">
        <property type="protein sequence ID" value="EFI33164"/>
        <property type="gene ID" value="Dthio_PD0487"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34185">
        <property type="protein sequence ID" value="EFI34185"/>
        <property type="gene ID" value="Dthio_PD1534"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="118"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="338" mass="39701" checksum="77E01B6FAA5B2618" modified="2010-08-10" version="1">MNLGSCLHTFFDQYLPRTKGVSSNTILAYRHTFSLFLPFASKTLGRDINSLEIEHLSTQLILDFLDHLESGRNNSARTRGHRLAVFKSLARMIRFLYPEHKLLADRIISIPQKRFPKKLAAFLTHEEVLLVLDSINLKKSGAFRDYTIIHLLYNSGARAEESASLRLDYFDPHKKTLAILGKGNRYRQIELWPKTVQLMSMYIQKYRPRPKPLHQNTLFLNQRRQGFTRNGIYRLCRKYLSLVFEENRFQGLNPVHCFRHSCAINMLGTGFSLTDIKNHLGHENLQSTMVYLKLSLNRKRELQQKFIEYTQNQTQDPKLDELLDWEKEQETLDWLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNB1</accession>
    <name>D6SNB1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869565.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1588"/>
    <dbReference type="EnsemblBacteria" id="EFI34237">
        <property type="protein sequence ID" value="EFI34237"/>
        <property type="gene ID" value="Dthio_PD1588"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017507">
        <property type="entry name" value="Tscrpt_reg_HipB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03070">
        <property type="entry name" value="couple_hipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="8022" checksum="1100F2848023D9AA" modified="2010-08-10" version="1">MTQPVEDTRKIGRIISEKRKADGLTQARLAALSGVGVRFVGELERGKPTARLDKLFKVLDGLGLYLAVKKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNJ2</accession>
    <name>D6SNJ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869646.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1669"/>
    <dbReference type="EnsemblBacteria" id="EFI34318">
        <property type="protein sequence ID" value="EFI34318"/>
        <property type="gene ID" value="Dthio_PD1669"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="14500" checksum="8372C02E2353E942" modified="2010-08-10" version="1">MSAIKDFINEHDRFARMSGIELVEVNQGSALARMTIQEMHLNGLDMVHGGALFTLADLAFAAASNSRGQAAVGINASISYIRPAKAGTVLSAQASEIFSHRTLSGYSVEVKNDQDKLVATFQGTAFKKDFPLVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNK1</accession>
    <name>D6SNK1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869655.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1678"/>
    <dbReference type="EnsemblBacteria" id="EFI34327">
        <property type="protein sequence ID" value="EFI34327"/>
        <property type="gene ID" value="Dthio_PD1678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087994" evidence="2">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="7589" checksum="BD60D2DA5D3A0F67" modified="2010-08-10" version="1">MRLMKILLTLAAVLMLAFSMGCGPQHEPAGAPGGYEQPDPEGYEAPERGEPGQQPGQEPGAEPGAEPGQEPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNM0</accession>
    <name>D6SNM0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinamide mononucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869674.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1697"/>
    <dbReference type="EnsemblBacteria" id="EFI34346">
        <property type="protein sequence ID" value="EFI34346"/>
        <property type="gene ID" value="Dthio_PD1697"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="192" mass="22233" checksum="E99B1B67EF32DEFD" modified="2010-08-10" version="1">MNVYDTAVIHGRFQILHNDHLKYLLAGKAMCRHLVVGITNPDPVLTNSVEVDPGRSHVMSNPLTYFERLVLVREVLLEAGLSHQEMTITPLPITRPELFRHYVPMDALFVLSIYDGWGRQKLEQFKSLGLNTHVLWEVNPEQKGISAQDIRELILKDQNWEHLVPEASARLLKKWRIPDRLRQMQQESIKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNM6</accession>
    <name>D6SNM6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase vitamin-B12 independent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1703"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <keyword evidence="2" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="391" mass="44315" checksum="2E77662C83C47770" modified="2010-08-10" version="1">MFTTTQVGSWPRSKKMLKALRDHRLGRMSKEEFHSIADDEVARTVEIQEKAGLDILVDGEHRRDNFYSFITDKVEGTKLMSLAEMLDEVEDKSGFEEMLDKLDVPASAIRNPTCVGRMQRREPLALNDFLFVKTLTDKPVKVTLPGPYLLSRSMWVTRYAGKFYKDQFEMGDDVVHILRSELEELAQAGCEFVQFDEPVLTEIVMSQECGRRTFMUATLATRRDVGEELDYAAELMNRIIDGISGPRTGIHICRGNWSTREDVLLTGDYEPLLPALTKMKVHQYVLEYATPRAGEIKVVGEALSGSIPGTDIPRELGLGVVNPRTTEAETPEEIMDKTRLALQHYRPEQLFLNTDCGFGCFANRCVNVEEVATAKIRSIAEAARRLRKEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNN9</accession>
    <name>D6SNN9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoB--CoM heterodisulfide reductase</fullName>
            <ecNumber evidence="2">1.8.98.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.1" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869693.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1716"/>
    <dbReference type="EnsemblBacteria" id="EFI34365">
        <property type="protein sequence ID" value="EFI34365"/>
        <property type="gene ID" value="Dthio_PD1716"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="647535at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051912">
        <property type="term" value="F:CoB--CoM heterodisulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="150"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="303" mass="33988" checksum="54769114840F4898" modified="2010-08-10" version="1">MQKYGMYLGCNIPFKAPDIEQSFRKVFPALGVELEDLQGASCCPAWGTAPSFDMDTWCAISSRNIVLAEEKELDLMTGCNSCFGVLSEAKHFIEDNPERKKRVNEKLQAIERRFEGSAGVYHVSHVLHEKVGTDRIRQGLTYSLEGLKAAIQPGCHVLWPSDVYQVKEKNPFFPTILKELTQALGAEVPHYSRLEYCCGMGGMRTTDVEKSLGLFTDKILSIKEEIDPDFIVTTCSSCFLQFDMSQPILKERGVIDFTIPVFYYTQVLALALGFDPSHVAAISQTPRDAVIAEIQSEKRKIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNQ1</accession>
    <name>D6SNQ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1729"/>
    <dbReference type="EnsemblBacteria" id="EFI34377">
        <property type="protein sequence ID" value="EFI34377"/>
        <property type="gene ID" value="Dthio_PD1729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="47" mass="5387" checksum="0DD0F4FA9F0BF6B1" modified="2010-08-10" version="1">MPCPLSYTEEQSRLNVAMHRAKINFFLCDLCLSRLGLIKCVSTSKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNS9</accession>
    <name>D6SNS9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34405">
        <property type="protein sequence ID" value="EFI34405"/>
        <property type="gene ID" value="Dthio_PD1762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14477" checksum="D033AD30BCE4D7EC" modified="2010-08-10" version="1">MLAAGMNMGHYCRLCGRIRPNERFSGNGHRIHVCNDCAKMPKADRDAIEQEEEICGFMRQSHISDKNIARLRALSASDNSRIADLASLVLDVAKVKPYKKRRLKVLARERRDLLEALERTGLIHVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNT4</accession>
    <name>D6SNT4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869733.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1768"/>
    <dbReference type="EnsemblBacteria" id="EFI34410">
        <property type="protein sequence ID" value="EFI34410"/>
        <property type="gene ID" value="Dthio_PD1768"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029118at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009387">
        <property type="entry name" value="HigB-2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039032">
        <property type="entry name" value="HigB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="12007" checksum="C4728C2B9EE6894C" modified="2010-08-10" version="1">MIFIETTIFTKLLPKYLNDDEYRALQWYLLVYPDAGDIVRGSGGVRKIRWAPKGKGKSGGIRFMYYWKKSVEEIWLLTLYSKSERATIPGDVLKKIAEEIENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNW4</accession>
    <name>D6SNW4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoA-substrate-specific enzyme activase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869762.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1799"/>
    <dbReference type="EnsemblBacteria" id="EFI34440">
        <property type="protein sequence ID" value="EFI34440"/>
        <property type="gene ID" value="Dthio_PD1799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8032at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018709">
        <property type="entry name" value="CoA_activase_DUF2229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09989">
        <property type="entry name" value="DUF2229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="334"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2229" evidence="4">
        <location>
            <begin position="694"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113189" checksum="8E6E0DA0836561EE" modified="2010-08-10" version="1">MTYDVGLDVGSVSINCCVVDSHGEIAFEAPYKRHFGLILEETRKTLSDIYNRFDPAQIDSVSFTGSQGQIVSQLLDAPFEVETIAQVLGTTRVLPGVRSLIAIGGQDAALFQLEYDQDNNWYLEAFNLNSPCASGTGSFIDQQAERLAYAMYGGDFEMDQNQLQKVLRDFIALGLQSTYPAPVACRCTVFTKSDMIHLQNKGESLSNIIAGLHHGTAANYLSTIVSNRELHEPVAFIGGMAENELLVQAFRKHFPQLQVPEHHTALGALGTALQSQKQGRKNTVKPESLDESMATSAYSFPRAETLELNLSHFDPDNSLKPVKSPARGTIKAFLGIDIGSTSTKYSLVDEQGRIIHKRYVATKGKPIEVAQELLQHLDQEVGDKIDLQAVGTTGSGRNVVGDFLDADLIIDEITAHARGAVKVDSGIDTIFEIGGQDSKYISIQDSHPVDFVMNKICAAGTGSFLHELANKMNINIVGQFQDIALSAPAPVNLAERCTVFMESDLVGYSQKGAKRDDLIAGLCFAIVRNYLHRVVESRHIGNKIMFLGGPSLNKGIVAAFEQVLQKPVIVPKNREVMGAYGTALAVQEKFNSGEIKVKERDLKDLAAIEVNFKESICRADKNCHNECKLKIYNFGGRKSIWGGDCGRYEASTVQGRTKDNFFLLRGELFNQHLPQDALVDWKSMEKPRPGQPIVGIPMALHSLEWGILWANIFSELGLNVLFSPATNHDIASTGVESMTAETCFPVKVFHGHVNHLQRSPADYLFLPNPINVPTPDEDGERGVLCPMVESSQYMATAALQLDESRLIRPTLFLKEGIESIAQNLYKALPPGLKFREKEVQRAVSLAWVRQMEFKKTMQQKGREIISGLDQTSPVWVVTGRPYNLYDERLNLRLGRQLAKLDITALPMDFVDFEQVNLKDFPRMYWGLGGRILRTAKLIAQKPNWFGVHLTNFSCGPDSFLEHFFGHILQQKPPLVLELDEHSAVAGVLTRIEAYKNVVQNILKENLVKKEKRTSLDQAVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP30</accession>
    <name>D6SP30_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP dicarboxylate transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869828.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1865"/>
    <dbReference type="EnsemblBacteria" id="EFI34506">
        <property type="protein sequence ID" value="EFI34506"/>
        <property type="gene ID" value="Dthio_PD1865"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="903568at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="427" mass="45396" checksum="CDD57B679D721070" modified="2010-08-10" version="1">MSPATVLFGYFVILLLMGSPIAVALGVSAMITFIYVGTDLSSIVQIAFNSVNSFPIMALPAFVLAGALMDCAGISKRLVHIAETMVGKISGGLAITTTLSCVFFGAISGSGPATTAAVGMLMIPAMIKKGYNKGYAGAATASAGGIGIIIPPSIPMVIYGVTSQQSITKMFLAGVIPGLMIAMGLIIVHFLLCRGTNYSEDMEEFSLRRFLLAVKGGFWAILAPVIILGGIYSGIFTPTEAAIVAIFYTLFVGIFIYREITFAGLEKSLTTTSWLTGRVLIIMFTAFAFGRILVENRIPDLIAQQLLSITSDVHLLLILVVVFLLFLGMFMETLALILIVTPVLLPVMTILGVDPIHFGVILVACCGVGFSTPPLGENMFIASGIANVTLEEISWKALPFCAVTIGMIILMVFFPQTVLWLPTILGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP62</accession>
    <name>D6SP62_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">secA</name>
        <name evidence="20" type="ORF">Dthio_PD1910</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869858.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1910"/>
    <dbReference type="EnsemblBacteria" id="EFI34538">
        <property type="protein sequence ID" value="EFI34538"/>
        <property type="gene ID" value="Dthio_PD1910"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="2"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="403"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="787"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="787"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFI34538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="838" mass="95796" checksum="FEEB199C4EBE764F" modified="2010-08-10" version="1">MFNIVKKIFGSKNERYLKSLRPLVERINSLEEEISSLSDEQLQSRVQAWKEEAAAGASLDDLLPHVFAVVREASHRVLGMRHFDVQLIGGIVLHQGRIAEMKTGEGKTVVATLPVVLNALTGRGVHIVTVNDYLARRDAEWMGRLYNFLGLDVGVVVHGMSDEDRRQAYAADITYGTNNEFGFDYLRDHMKFYAYQLVQRDLQFAIVDEVDCILIDEARTPLIISGPADISVDLYARMNSMVPKLKKDEHFNIDEKAKTVTLTEEGVHRVENILGLENLYDPENITYQHHVLQALKAHHLFGRDSEYIVKDGQVIIVDEFTGRLMPGRRFGDGLHQALEAKEGVKVEAENQTLASITFQNYFRLYDKLAGMTGTADTEAVEFKEIYNLDVSVIPTHKPMIREDLPDVVYKTQQEKFNAIADDLLELHSRGQPVLVGTTSIEKSEHLSKLLNKREVPHEVLNAKHHEREAEIVARAGEMGRVTLATNMAGRGTDIVLGEGVRELGGLHILGTERHESRRIDNQLRGRAGRQGDPGSSRFYLALDDSLLRLFGSERITGMMDKLGMEDGQPIENNMISRAIENAQTKVEAHNFNIRKQLLDFDDVMNQQRTVIYTQRRELMHAEKLEDYVLDMIQDVLDDVYSPVGESTPDSLEDEEERSMLMGRLEEIFNIKRLLPEVESPEKEKTLNAVHAHLEQLKADAGDQYEEVLRFFLLESLDRNWKEHLLQMDHLKQGIGLRGYGQRDPKREYKREGYELFEELLFRIKENVVRALCRLRIRKKEEVEGFRHKEQEDLRYGAPQKGEEKKEAKKEPQRRAEPKVGRNDPCTCGSGKKYKKCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP69</accession>
    <name>D6SP69_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="10">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycogen branching enzyme</fullName>
            <shortName evidence="10">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glgB</name>
        <name evidence="13" type="ORF">Dthio_PD1917</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869865.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1917"/>
    <dbReference type="EnsemblBacteria" id="EFI34545">
        <property type="protein sequence ID" value="EFI34545"/>
        <property type="gene ID" value="Dthio_PD1917"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="227746at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="149"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10 11">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="627" mass="73487" checksum="FE5BC7351DF9C417" modified="2010-08-10" version="1">MFTEQDIYLYKQGRHFRLYKHLGAQVVMHGGVRGTYFGVWAPNAEQVSVIGDFNYWDNTTHQLNVRGDGSGIWEGFVPEAMPGHKYKYHIRSRFQGYSVDKGDPFGFYWETAPSTASIIWQMDYQWGDEEWMQNRREKNRQDKPLSIYEMHLGSWMRDPDNPERLLSYRELADRLPGYLVDMGFTHVEFMPVAEHPFYGSWGYQILGFFAPTSRYGTPQDFMYLIDVLHQHGIGVILDWVPSHFPTDEVGLGFFDGTHLYEHMDSRKGFHPEWKSYIFNYGRNEVVSFLISNALFWLDYYHIDGLRLDAVASMLYLDYAREDGDWEPNEFGGNENLDAISFLKHLNSEVYRSYPDVQTFAEESTSWPMVSRPTYVGGLGFGYKWNMGWMNDTLSYMSREPVFRKYHHNQMTFSIWYAFTENFVLPLSHDEVVHLKGSLVTKMPGDDWQKLANLRLLLGYMYAHPGKKLLFMGAEMAQWTEWNHDKSLDWHLLQYDRHRQVQDWLREVNNLYRNRPQLYELDFEPGGFSWIDCTDSDNSVLSFIRRDKEKKPLIMAANFTPVPRHDYILGVPGPGPYREILNSDDARFGGSHLVNPDVYHAQEIQAHGYSHRLSLTLPPLGILFMEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPF4</accession>
    <name>D6SPF4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869950.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2002"/>
    <dbReference type="EnsemblBacteria" id="EFI34630">
        <property type="protein sequence ID" value="EFI34630"/>
        <property type="gene ID" value="Dthio_PD2002"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088008" evidence="3">
        <location>
            <begin position="27"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="245"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="359" mass="40747" checksum="3FA4514B00A10DE4" modified="2010-08-10" version="1">MFKSVRGSFLIMFVAAVLMGAQHAMAETRTILEPRADNFIFYVDNSGSMMFDYEELGKDKSVVARDTLLQLNQEIPELDVNFGVYTYGPYNEFLSPSSYNESAVAEAFESIPVEFEIFGRRTPMGRDLIQVSDELAELQGDIAVIAVTDGESNIGPRPGRVMEEMYQEYGDRICFHFISLAQSDAERSNVQDWAGINPCSVKIDADELQKEFVRADFIREVFYTEREETVTPAPEPEPEPAPEVEPEEEVIVFSNIQFDFDSAAIKDEYAEILNEAARQIQDRTDPHVVVEGHTCNIGPEDYNMELSQRRADSVADYLVEQGVDEDAIDTEAHGLTRPEFDNDTREGRQLNRRVEMRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPL1</accession>
    <name>D6SPL1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870007.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2059"/>
    <dbReference type="EnsemblBacteria" id="EFI34687">
        <property type="protein sequence ID" value="EFI34687"/>
        <property type="gene ID" value="Dthio_PD2059"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="291"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="506" mass="57158" checksum="B99AB91EFB3E10EA" modified="2010-08-10" version="1">MSQEEDFLHQEQLCILEEVEKGFNIGIIGTGTGFESILQLTRNPDLEEFFPRLNLVALSQPYSRDRRLRKALEMGVKLYESHHDMLKAHPEINLVIELTDKQHMVKKLRKSLPANISMVDHNAATFLCGMLIMAEVSNKCRLNLKQQRALFEAVTDQIQDDILLLNTSGVIQDVNMGVVKRMDRKKEDIIGKHCWELFACSDASSGPGFNGTECPFRTTMEEHRPAEAMQTWVDEQGRAHYFRIYTYPVFDAAGQLSRVVEMRRDITVRTEMEKRLQQSEKLAAIGELSTYIAHEIRNPLFAIGGFANAVLRNPDLDAVSRDKVNIILQESKRLDRILKSIINFARPTEPVQQEVDVNGVVQEVMQLFNLTCKEQDVSIEMEMPPNMAKARGDPELLKQCIINLVKNALEAMPEGGTLGLETFVEWEFVVIEVSDTGKGISKEIRDKIFNPFYSTKENSGAGLGLAMTKKILDDMGGKIDVLSLEGQGTSITIRLPLFPAMPEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPQ3</accession>
    <name>D6SPQ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870047.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2102"/>
    <dbReference type="EnsemblBacteria" id="EFI34729">
        <property type="protein sequence ID" value="EFI34729"/>
        <property type="gene ID" value="Dthio_PD2102"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50344G3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1834712at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="189" mass="20893" checksum="298C3A8AA0E6C095" modified="2010-08-10" version="1">MAVTDLMCSVYQGFNFQKDQQDRVGHITSLTIGDDEISADLKVTDPEDLSATVDAVGVISRIAWDGGFAEPIIASFRVSRSNKNVLATKQHQSLAKTGVKIAFNVYEYDQGNSAYFKCFHTDETDLNGVIYKRGGELQFNVELEEAQDVMKPSNYEMFLGVAPTDEAQEIQMAISVSDKFTKGWGVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ33</accession>
    <name>D6SQ33_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870173.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2250"/>
    <dbReference type="EnsemblBacteria" id="EFI34859">
        <property type="protein sequence ID" value="EFI34859"/>
        <property type="gene ID" value="Dthio_PD2250"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="54"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="85"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="321" mass="35001" checksum="3419E1C19A390BF1" modified="2010-08-10" version="1">MKDTNNKQRNTTGCSRRDFLAAAGMAGAGLVAWPGFAAHAGEGKPEASRTGVGLALGAGGANGLAHIAVLEALDEIKVRPKIIAGSSIGAILGVLYASGISGREMREAALEIFDSQPSIWGGWLERITGSGLLDMLRPGLGEGGLLDPEGVLDFVREKIQVQDFEELQIPLKVVATDFWRREQVVFDSGEIIPAIEASMAVPGLFAPVRYQDRLLVDGAIVNPVPFDLVLDSCDISVAVDVSGKSSPDNKERPSYLDTIFATFEIMQESIMQQKLRIYSPDIYLRPEVVDVRLMQFNKIKRILKEAEPARERLKEELERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ49</accession>
    <name>D6SQ49_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870189.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2266"/>
    <dbReference type="EnsemblBacteria" id="EFI34875">
        <property type="protein sequence ID" value="EFI34875"/>
        <property type="gene ID" value="Dthio_PD2266"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="310" mass="32554" checksum="28DA6B41C146ACB1" modified="2010-08-10" version="1">MSVIAGQTGHRIEISQLKGTLLGSMAVLMWGFLPLLRLMAGEVPPLQLTFMSLFTAALAVLTWGKTRRKIYGKPWHDHGQRDVFLAAGFLLGAVVFYFAALMQAPAAEVALITYLWPLGLAAAICISAGRRPGLNMWTGLLLSFSGAALALLSGNEGQGGSTMDPGRAAGYALGLASGACWLGYSLMLGRLPTNAGLHAGIFAWAGIAAALLHLLLEHTVLDLSFAVLLTTACIGIGPYGLAFMAWGQGLRYGHAGLLSALCYTVPVVATTLLILAGMEAWRMELALAALAVTCGAWLAGRDRNKTLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ56</accession>
    <name>D6SQ56_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870196.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2273"/>
    <dbReference type="EnsemblBacteria" id="EFI34882">
        <property type="protein sequence ID" value="EFI34882"/>
        <property type="gene ID" value="Dthio_PD2273"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="159"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="700" mass="79722" checksum="24558897FE5C9B05" modified="2010-08-10" version="1">MKVWPGTPYPLGATYDGSGTNFSLFSGIAEKVELCLFDADGQETRVELPEVTGHCWHGYLPEIEPCQHYGFRVHGPWQPEEGHRCNPAKLLLDPYAKAVDGQIKWDEALFPYNLQDGPESRNDKDSASFMPRSVVHQPDFDWGGDRLLGRPWHETVIYETHVKGFSMRHPEIPENIRGTYAGLGHPVAVEHLQKLGITAVELMPVHYFIHDKHLVDKGLRNYWGYNSIGFFAPHSEYASGNRPGEVVAEFKQMVKNLHQAGLEVILDVVYNHTGEGNHLGPVLSFKGIDNAYYYRTMPDDARYYMDYTGTGNSLNMRHPHVLQLLMDSLRYWVLEMHVDGFRFDLASTLARELHDVDRLSAFFDLIQQDPVISQVKLIAEPWDVGEGGYQVGNFPPVWSEWNGKYRDCVRDFWAGRDQTLGEFAYRLTGSPDLYADDSRQPFASINFITAHDGFTLRDLVSYDRKHNEANGEDNNDGHDDEGSWNCGAEGPTDDPEVLALRARQQRNFLATLILSQGVPMLLGGDETGRTQQGNNNAYCQDNEISWYDWENADLDLLAFTEKLISYFHRHPVFRRRRWFHGREIHGLEITDIAWFTHLGEQMSEEDWGSGFAKSLGVYLNGGAIPNPNPKGEPVTDDSFYLIFNAHYEELEFTLPPDTWGGSWRLEMDTLSGWLEEEKILQAGEEIAVAARCMVVLRHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ58</accession>
    <name>D6SQ58_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870198.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2275"/>
    <dbReference type="EnsemblBacteria" id="EFI34884">
        <property type="protein sequence ID" value="EFI34884"/>
        <property type="gene ID" value="Dthio_PD2275"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1506728at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044036">
        <property type="entry name" value="DUF5752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19027">
        <property type="entry name" value="DUF5752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="227" mass="26404" checksum="C12FD9B298F30443" modified="2010-08-10" version="1">MNISNLSQPEPFALKDCALITIATGRKAHTLAELRDHIRDVNLDSVYHHFWGGLLGARFEEREFNNDFAVWCRRQLREQALAEQLAVIDPVEHRDLEDLRRELLETIEGRLDESETAHWLQAFRPFEFIRSQLVIFDTGTRLARPEALAEVIPELSTGTIFYHFIDARRRVPGGLDDFSYWLMGFEEPYFELRRGLAGIDPFFSSLSSIREEMTRVCLECRDRGDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ80</accession>
    <name>D6SQ80_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M16C associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870220.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2297"/>
    <dbReference type="MEROPS" id="M16.012"/>
    <dbReference type="EnsemblBacteria" id="EFI34906">
        <property type="protein sequence ID" value="EFI34906"/>
        <property type="gene ID" value="Dthio_PD2297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M16C_associated" evidence="3">
        <location>
            <begin position="457"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="424"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="971" mass="111619" checksum="8721B5B1D709BBC1" modified="2010-08-10" version="1">MQQANRFRLVEERHIPEINSLARLFEHQKTGARVLSMTNQDENKVFGITFRTPPRDNTGVAHILEHSVLCGSRRYRVKEPFVELLKSSVQTFLNAITFPDKTCYPVASQNRQDLYNLMDVYLDAVFFPNIPPEVFAQEGWHYELPSQDAPLKFKGVVYNEMKGAYSSPESLLAEYSQQSLYPQGTYGLDSGGIPEEILNLTYDDFIQFHKKFYHPSNAWIFFYGDDPEQERLDRVGEFLDQFDPLDVNSQVNTQPRTDMQKRVEESYSATDESDPRCYLTINWLLPETSYPQLNLGLRILDFILTGMPASPLRRRLIESGLGEDLAGVGLETDIFQMYYSTGMKGVPPENLDRVEALIQETLQDLARNGIDPEIVQAAMSSVEFALRENNTGSFPRGLAVMFRALSTWLYDESPFSLLEFSDVLEQIKLRLEQGEKVFENLIQEHFLDNTHRTVVLLRPDSDMERRIQEMENQRLEEARKQLDQKQMQELVESTQKLMKWQEEPDDPEELARIPRLTRSDMEPQIRTVPRREEKVQEATLLMHPQPTSGIFYLDLGMDLHFLPQKYLSYVPLFGRALLEIGTFSQDYTALTTRIRQLTGGIVPVPFSHSVRGSSESTCRLFLRGKSLPEKVPDMFKIFRDILTQVKLDNKERFRQMVLEEKSGLEQALVPAGHRVVGMRLKARYSEADWAQEHMSGVTYLLFLRHLLEKIEKNWDQVLSDLEGIKSLLVHKGSMLVNITAEEDALDQGRQYLQDFLQEIPREEASRQHWKWSCTPGNEALYIPARVNYVGRAVDLESGSYRFHGSSMAATRFLRASWLWDKIRVQGGAYGAFSSYDHFNNVMAFTSYRDPNITKTLQAFAGSGAYLSRPDLDPEEVEKAVIGAVGEMDSYQLPDAKGFSSMIRFLANITDEYRQNIRDEILGASVENFREFGQALDQALREDKGVISILGGQSQIEEHQEELELENSFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQE9</accession>
    <name>D6SQE9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoB--CoM heterodisulfide reductase</fullName>
            <ecNumber evidence="3">1.8.98.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.1" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870289.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2367"/>
    <dbReference type="EnsemblBacteria" id="EFI34975">
        <property type="protein sequence ID" value="EFI34975"/>
        <property type="gene ID" value="Dthio_PD2367"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="647535at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051912">
        <property type="term" value="F:CoB--CoM heterodisulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="2">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="2">
        <location>
            <begin position="146"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="312" mass="34206" checksum="737C0EE5263E8961" modified="2010-08-10" version="1">MRNFAYYPGCSGLGTSMEYDKSTRAVCKALGINLMDINDWSCCGSTPAHTVDHLLSSALSGRNLALAEEMEAEAMITPCPSCLSNLKGTVHRLSDRGFRHKVNNLLEKPVQRTMPVKSVLQILDEEVGSRELAERLPEKPLRGLKVATYYGCIMNRPPEVMQFDDHEHPMAMDRLMQALGAEVLPFPLKVECCGASFGIPRKDVVATLSGRLLDTAQALGAHAMVTACPLCQMNLDLRQGQAASVMGKEFNMPVFYYTQLIGVALGLPQKELGLSKLCVKPSIAFDAMRSNREQEPVSKSAGKKKPETKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQJ5</accession>
    <name>D6SQJ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multiple resistance and pH regulation protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870335.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2415"/>
    <dbReference type="EnsemblBacteria" id="EFI35021">
        <property type="protein sequence ID" value="EFI35021"/>
        <property type="gene ID" value="Dthio_PD2415"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2083248at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="9789" checksum="AC73CBD696E95A75" modified="2010-08-10" version="1">MQTFFILISAALVLVLLLPFYRVLKGPTVFDRLLGAAAVGAKIITLVLLFGLVYGRPGMFVDIALGYAVLNFIGVIAVARYFRTASVKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQS3</accession>
    <name>D6SQS3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870413.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2493"/>
    <dbReference type="EnsemblBacteria" id="EFI35099">
        <property type="protein sequence ID" value="EFI35099"/>
        <property type="gene ID" value="Dthio_PD2493"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105459at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003748">
        <property type="entry name" value="DUF169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02596">
        <property type="entry name" value="DUF169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="276" mass="30918" checksum="6762CF96DC529B32" modified="2010-08-10" version="1">MQSRIASILKLKYQPAALTWSDEKPSGAIEFKADRWGCVMFSLASVVKGKTAVFSRQTYGCWGGGVGLGFGNKYQDFPGGEECFYNFLSSGNKNSEQGRAVGEKIREAGLGEFGDDFMEGERYIKTPDHVRSFVESLPITEVPAKYVVLKPLQEIQEETDNVQVVTFLVDADQLCALVVLANYGRHSFENVSIPFVAGCQAIALLPYAEALKEEPRAVVGLMDPSARKHLRRMLDRNLMSFSMPLALFREMENNVDDSFLFRNTWQAITGDWKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQU5</accession>
    <name>D6SQU5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870435.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2515"/>
    <dbReference type="EnsemblBacteria" id="EFI35121">
        <property type="protein sequence ID" value="EFI35121"/>
        <property type="gene ID" value="Dthio_PD2515"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="98"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="157" mass="16964" checksum="D994200643404C96" modified="2010-08-10" version="1">MTTAEDLMTSDPIRVHPETDISEAIHLLLEKNINGVPVVDQEDNLVGIICQSDLVAMQKKIPLPSMFTVLDSILPLGSTAKMDREIKKIAATRVEDAMTPEPVAVKKDTPLEELAEIMVDKKYHTLPVTEGGKLVGVVGKSDVLKTLVGPAKSNQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQU9</accession>
    <name>D6SQU9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication-associated recombination protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870439.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2519"/>
    <dbReference type="EnsemblBacteria" id="EFI35125">
        <property type="protein sequence ID" value="EFI35125"/>
        <property type="gene ID" value="Dthio_PD2519"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="977094at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="35"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="400" mass="44809" checksum="5A9071959597EE04" modified="2010-08-10" version="1">MQKPLAEKIRPQSIEDFVGQSHLRTRLRAMGQSQRLQSTLFFGPPGCGKSTLALIIAGNQGKSHLRLSAPEIGLAELRKKLEGLEILILDELHRFSKAQQDFFLPLLETGEIILLATTTENPSFSVTRQLLSRMNVLRLRSLSMPELRQIGERAVKELDVSIPEKSLDLLASLSGGDARTFLNLMEYVRELDQENLEPDKLKTVLPEAVIKGDRDGDMHYELASAMIKSIRGSDPDAALYYLACLLEAGEDPRFVCRRLILSASEDVGLADPMALPLAVSCQHAVEFVGMPEGFIPLAEAAVYLALAPKSNSTYAAYLSAQKEIRHHGPRPVPLHLRNASTTLQKEWGYGQGYKYPHLYPGAWIEQEYLPSELAGRRFYEPKDQGQEPRLLAWLRKRKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR16</accession>
    <name>D6SR16_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33132">
        <property type="protein sequence ID" value="EFI33132"/>
        <property type="gene ID" value="Dthio_PD0450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="59" mass="6371" checksum="6BFC4F54874FD503" modified="2010-08-10" version="1">MSGARPLTLESENDFKGGVCGVYVKTIPSKAGYAGYVKNKKILKAGGLKRVIAGYWQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR36</accession>
    <name>D6SR36_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870515.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0475"/>
    <dbReference type="EnsemblBacteria" id="EFI33152">
        <property type="protein sequence ID" value="EFI33152"/>
        <property type="gene ID" value="Dthio_PD0475"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891199at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="213" mass="24626" checksum="6B451077DCD419C6" modified="2010-08-10" version="1">MTRKVIIFTDGMFMRRRVLERNHFLYKPREIREYCQKHLRPNDYLVRIYYYDCKPLQARGTSPLNGKEIDFSRLESARLRHQLFEGLRHAPNFCLRLGSMEWNGRDWNVVGSKVSPLLKKEITVDDLSDSDIRPGSETTQISVKMALDMITLAARKAGDMFVLITDRTDLVPAMEMVRQEGVQVCLDNMHAPVSIELSEQADFISTNLGNKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRA6</accession>
    <name>D6SRA6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870580.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0548"/>
    <dbReference type="EnsemblBacteria" id="EFI33222">
        <property type="protein sequence ID" value="EFI33222"/>
        <property type="gene ID" value="Dthio_PD0548"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="4"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="455" mass="49413" checksum="1022B13C898F0BD6" modified="2010-08-10" version="1">MGYKAVNPATGEELQSVACIGSRELESALEESFQAYLQWRETGYECRAGLVGAVGEILRQNSKKYADIITREMGKPIAAARGEIDKCARLCDFYAEHGAGYLSDEEIKVDSGRSFVTYNPLGPVLAVMPWNFPFWQVLRFAVPALMAGNTCLLKHAANVPGCAAEVEKVLLQAGLPRGVFSNLFINKEQALEILGDGRVRGATLTGSVSAGRAIAERAGSMLKKTVLELGGSDPYLVLEDADLELAARTCAASRLMNNGQTCIAAKRIIVVQKVYDDFMDLFLQEMARANMADPMHDDCTLGPMAREDLRRELHGQVERSMGQGARLELGGYIPEGPGFWYPGTVLSGVKPGMPAFEEELFGPAAAVISANDEKEAIELANRTRFGLGSAVFTRDIERGTRIASSEIEAGSCFVNSMVQSDPRLPFGGIKDSGYGRELSVQGIREFTNIKTVFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRF1</accession>
    <name>D6SRF1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CutA1 divalent ion tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870625.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0593"/>
    <dbReference type="EnsemblBacteria" id="EFI33267">
        <property type="protein sequence ID" value="EFI33267"/>
        <property type="gene ID" value="Dthio_PD0593"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1801957at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="107" mass="11965" checksum="CA25DC04765514CD" modified="2010-08-10" version="1">MSHVFAYITAADMQEAQRVGRALVENGLAACVNALDNMTAMFMWKGQMETEKEVVLLAKTREDLKDKLVQKVLEVHSYECPCVVFVPIQGGHTEFLDWIDTETGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRJ9</accession>
    <name>D6SRJ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trimethylamine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trimethylamine methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870673.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0642"/>
    <dbReference type="EnsemblBacteria" id="EFI33315">
        <property type="protein sequence ID" value="EFI33315"/>
        <property type="gene ID" value="Dthio_PD0642"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1052788at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015948">
        <property type="term" value="P:methanogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038601">
        <property type="entry name" value="MttB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010426">
        <property type="entry name" value="MTTB_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06253">
        <property type="entry name" value="MTTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="491" mass="54954" checksum="27D05E0161585C80" modified="2010-08-10" version="1">MASDKTNCTVNRSPRFSFLSEDQKQTIFHGMLKVLQDTGANVHHEQAREIFKKHGCKVDGIRVYIPPKLVRQALQSVPLMTTIFDWEGNPRIYIEENRSYFGPGPTLVYFRDPYTMERRKCLRQDATTVARVCDALPNIGFVEGLVTISDVPRGTDDVYEFADMIQNTTTPIMAWSYQRGGARDIHRIGCIMAGGEEAFRKKPNYILYSEPISPLVSDFHAIDKLMYCAEQGIPQDYSPCAIGGGTVPATHAGQLVVALSESMVGVVLSQLINPGTCIILGGVQSILDMRRGIYAYGAPELNVLSGGLTEMARYCGLPMFGTAGCTDTKVMEIQSGIEATLQIHTSMLTGANFVHDCGYTESGKTGDIFQTVMDDEIISMARIIEDGIEVNEETLSVDVINRVGSGGHYLYEDHTMKWFRKHWRPTLMDRQSYEDWVKNGSQTMQDRIIKKTRDILETHEGPISRVPRDVQKDVQKVVDEAVERVEREGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRK1</accession>
    <name>D6SRK1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid-binding ACT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870675.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0644"/>
    <dbReference type="EnsemblBacteria" id="EFI33317">
        <property type="protein sequence ID" value="EFI33317"/>
        <property type="gene ID" value="Dthio_PD0644"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1859752at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016867">
        <property type="entry name" value="GcvR"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028103">
        <property type="entry name" value="GcvR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="99"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="182" mass="20789" checksum="41AA7A46A836A827" modified="2010-08-10" version="1">MQNQYILAAMGSNRPGVVADVTGSIYKAGCNIENSFMTLMGVHFTLMIHVIAEDEDKADRLNRNLESLEQKEDLKVHIFPMESDEIEISRARKDQPRYEIRVRGQDKAGIVYRTSKLLASRGINILKLSTKVDRSKHLQQPIFTMRIGIEVPKNVDGHSLRMDLESLAEDTQETFTLTRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRT3</accession>
    <name>D6SRT3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870756.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33399">
        <property type="protein sequence ID" value="EFI33399"/>
        <property type="gene ID" value="Dthio_PD0730"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033BFW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2045422at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045944">
        <property type="entry name" value="DUF6364"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19891">
        <property type="entry name" value="DUF6364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="8958" checksum="64F2E0AD0CB8320C" modified="2010-08-10" version="1">MNITLSADKELIQKAREYAAQRGTSLNQLIREYLEHTAAMGDKESNAREFERLARECGGTSPKGYVFDREDAHGRGEDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS17</accession>
    <name>D6SS17_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870835.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0817"/>
    <dbReference type="EnsemblBacteria" id="EFI33483">
        <property type="protein sequence ID" value="EFI33483"/>
        <property type="gene ID" value="Dthio_PD0817"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1725857at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="23432" checksum="51A9199EFEFF9FA9" modified="2010-08-10" version="1">MTRNILSSKSFSLAKLLLYLCLPFILATLALGCRGASSNLHAIYADEPEVYTKYNIHAQDSGRDIKASYAGFVDPGDGHIIIPAGSEIEFPDRRARRNGFYFKVMDTGQMVFFEYHSGRMEMSEEQYVELITSDEPVSIEGFSEIDQKGIEAGKALEGMSKDGVLTALGYPAKHRTPSLESSSWTYWRNRFVTSVVEFNAEGYVENVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS22</accession>
    <name>D6SS22_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (guanosine(18)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA [Gm18] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trmH</name>
        <name evidence="6" type="ORF">Dthio_PD0822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870840.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0822"/>
    <dbReference type="EnsemblBacteria" id="EFI33488">
        <property type="protein sequence ID" value="EFI33488"/>
        <property type="gene ID" value="Dthio_PD0822"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009020">
        <property type="term" value="F:tRNA (guanosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052665">
        <property type="term" value="F:tRNA (uracil-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002938">
        <property type="term" value="P:tRNA guanine ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18092">
        <property type="entry name" value="SpoU-like_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02060">
        <property type="entry name" value="tRNA_methyltr_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033671">
        <property type="entry name" value="TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43453">
        <property type="entry name" value="PTHR43453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="197" mass="22604" checksum="70EDD556A980A0DF" modified="2010-08-10" version="1">MKDTPRTDRRKLRIKDVLCRRQRDLTLVMNNIHDPHNVSAILRSCDAFAVPDVHLLYVGQPFPEVGRKSSASARKWVRRIRHRDAGEMVQRLEGQGLCLIRTGFGPQSISLPEWDFTRPTAVILGNEHSGVQEDLEQMVAQEIYIPMQGMVQSLNVSVAAAVILYEAFRQRHQAGLLEERALPGDRQDELYHEWIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSB2</accession>
    <name>D6SSB2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nickel-dependent hydrogenase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870928.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0913"/>
    <dbReference type="EnsemblBacteria" id="EFI33578">
        <property type="protein sequence ID" value="EFI33578"/>
        <property type="gene ID" value="Dthio_PD0913"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="450" mass="50727" checksum="DD522A93D7695DF5" modified="2010-08-10" version="1">MGKTLNIAPITRIEGHASVAVHLDDTGNVSDARLHVLSLRGFEQFVLGRPVEEVPRIVNRICGICPWQHHLASNKAADECLGLELPPTGRKLRELCQMMAYIPDKILHFYFLAAPDFVLGPDSDYSVRNVVGIVGANPELAKKVVHMRYKGQMMLEKFAGKVIHPIAGVVGGFSKPLKEEERKEILQGIQELKEFSLFTIKFAREEVFPKYLDAVKVLGVFPSGYLGTVRPSDGALELYDGELRLMDQNGEYDQFKYSEYMNYIGEHTEPWSYLKFPYAKKWGDLKLDENDPVGVYRANTLARINVCDQMATPKAQEELDIFRKEFGRPTHLTLLYHWARLIELVQACERAEELLNDPEITGREIRCQDIQPRAGEGVGCVEAPRGTLIHHYQTDDNGFVTMANLIVGTTHNNAPMNLSVRQAAKAVIKDGNYDQGLLNRVEMAIRAYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSE5</accession>
    <name>D6SSE5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870961.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0946"/>
    <dbReference type="EnsemblBacteria" id="EFI33611">
        <property type="protein sequence ID" value="EFI33611"/>
        <property type="gene ID" value="Dthio_PD0946"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50340SP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1836292at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="161" mass="18563" checksum="E9D7A780DC9791F7" modified="2010-08-10" version="1">MELNIVAPEQELPLERAYVVNMSIKSFKGRKNVEVHLFRGHWDPEELQSYDWTKILGKSLQEMEDGEKDAVRAIMEAFTRRERDHLVQYLQNRYAGRLTVINSAALPFPVPSGVVPLADMPEDENMGRIRLDKVPNYSLDFAVHGFYDLSAHPPILRDEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSF4</accession>
    <name>D6SSF4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="5" type="ORF">Dthio_PD0955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870970.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0955"/>
    <dbReference type="EnsemblBacteria" id="EFI33620">
        <property type="protein sequence ID" value="EFI33620"/>
        <property type="gene ID" value="Dthio_PD0955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="123"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="183" mass="21399" checksum="8535D8E366F9F041" modified="2010-08-10" version="1">MHIKFNFKSFEPSDHLKNYAQDRFEKLSKYITDNDDVSLQVNMEVEKFRHIAECILTGKDLHISANEETEDMYSTVDLSLDKLEAQLKKQRDKIKDKKKKTREKQQVRMDVVSFSPAEEGQSREPRIVATDQYEPKPMPLDEAAMQLENLGYEFLVFLNAETERVNVVYRRKDGDFGFIDPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSQ8</accession>
    <name>D6SSQ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA-ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871073.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1063"/>
    <dbReference type="EnsemblBacteria" id="EFI33724">
        <property type="protein sequence ID" value="EFI33724"/>
        <property type="gene ID" value="Dthio_PD1063"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191489at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="518" mass="60246" checksum="33EC61249B1CBF6D" modified="2010-08-10" version="1">MKKLPIGVSTLREIIEDGYTYVDKTRIVHQLVESGKYYFLSRPRRFGKSLFIDTLKEAFEGNQDLFQNLWLFDRWDWKKKHPVIHISFGAGVVRNREELDRRIVDLLYQNQKTLGVTCRDPGDIPGCFGELIRESAAKHGQRTVVLVDEYDKPILDNITDPEQAIEIREGLKNLYSVIKDSDAHIRFSFLTGVSKFSKVSLFSGLNNLRDITLSPHFATICGYTEAEMTEVFAEHLEGKTLEDIRSWYNGYSWLGERVYNPFSILNYLEEGEFSNYWFESGTPEFLLKLFLARKYLAPNLENTVATERLLGSFDVNDIEIETMMFQTGYLTIQERQQFGNLTAYRLDYPNLEVRMSFADSLSAFLVSQRDVYEKCKIDLYQALSAARLDDIGNVFHSLFAAIPHDWYRKNKLTEYEGYYASIFYCYFTALGLDVTAEDTTNHGRIDMTVRLANRVFIFEFKVLDLDKTPGTALEQVRKKGYADKYHGQNLEIYLIGVEFDRDERNIVRFDWEKSLSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSS5</accession>
    <name>D6SSS5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871090.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1080"/>
    <dbReference type="EnsemblBacteria" id="EFI33741">
        <property type="protein sequence ID" value="EFI33741"/>
        <property type="gene ID" value="Dthio_PD1080"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="396"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="582"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="692" mass="75929" checksum="6AA4AFF79D94CC61" modified="2010-08-10" version="1">MKNLRLGVKLMGGFGLVALIVLVVGFFGWRGANNLGGHVEEIGQVRLPSIDSLRQVEKEFETFSVAFRTLLNPNISMDERQAQYENIQEARSAYQRALEVFEPLPQTEQEAAIWRDFDPQLQRWAEVNNEFLDMSRELDDIGILNTNQFVGRLQDFEGDHYALMDNIGRYLLTGVDFEGGEDATACAFGRWMADFRIDNPEITQLLRDITPYHNAFHASVEDIREEVQAGNEQAAIDIYADQMVPAAQQTFEYFEELIQIAEYADELYAEMNELAMVDSVERQNAVMDILDQVIYINENVSGEAVEAAENDAANAVTIALAGMGIGVVLAVALGTLLTKAITGPVAKGVAFSEQMAKGDMTKDLDVHQKDEIGMLADSMRRMQEKLKEVVQEVKTSADNVAAGSEEMSSSSEEMSQGATEQASNLEEVSSNMEQMGSNIQQNADNAAQTEKIALQAARDAEDGGQQVQDTVQAMRDIAEKISIIEEIARQTNLLALNAAIEAARAGEAGKGFAVVAAEVRKLAERSGQAANEISGLSASSVQVAEKAGEMLKKMVPDIQKTADLVQEISASSKEQTSGAEQINKAIQQLDQVVQQNASSSEELSSTAEELSSQAQQLQSIIGFFRVDEHGSGRQEALRTAKYTAQQGGAKQDVRKSRMQLGQNKEQQGGRSKKRLSLDMGAEDAEDQEFEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSW2</accession>
    <name>D6SSW2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1117"/>
    <dbReference type="EnsemblBacteria" id="EFI33778">
        <property type="protein sequence ID" value="EFI33778"/>
        <property type="gene ID" value="Dthio_PD1117"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11112" checksum="B063BD9C0CE327C3" modified="2010-08-10" version="1">MTRKKGESKVKVFLDWCKGCGICAAFCPNKVLSVDKQGKVRVDREDDCINCGFCEIHCPDFAIMVYPKDERTPFEANIDDVAPATREELHRIRNSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSZ9</accession>
    <name>D6SSZ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871164.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1154"/>
    <dbReference type="EnsemblBacteria" id="EFI33815">
        <property type="protein sequence ID" value="EFI33815"/>
        <property type="gene ID" value="Dthio_PD1154"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1407561at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="172" mass="19886" checksum="A7603C076DE7494E" modified="2010-08-10" version="1">MSTQEYVCLRCSRVFPTCCRLSPGLEELCFPLSTQEKEGIQNHLQHSDFFVEQPNTADFIASVSRLLPDHQHKTRSIFALDTCHLRLKTLSDGKCILLQDDGCLLPRELRPFYCRLFPFWFLRGKLVFMTNSKCLAQHESSEVKNLLKLFRAEVSALQKDFNSMLRNLGLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST32</accession>
    <name>D6ST32_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871197.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1187"/>
    <dbReference type="EnsemblBacteria" id="EFI33848">
        <property type="protein sequence ID" value="EFI33848"/>
        <property type="gene ID" value="Dthio_PD1187"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1287580at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="179" mass="20262" checksum="D900EC7940D2FD91" modified="2010-08-10" version="1">MNETLASSMSPAFLVTTLSVTVALLATIVLFITINEYTRLRRLRREFQDFEENWKQEMQKTQKAMQRVVASYQINDPDQRIKILESAVAIDPGVYNGYNALGYAHLDKGDTAGAVDAFKEAIHQHPEQIEGYCDLARAYLKQGQESLARKYLARAEHIDASAVRQGLQGDDFLEHLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6STA8</accession>
    <name>D6STA8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871273.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1263"/>
    <dbReference type="EnsemblBacteria" id="EFI33924">
        <property type="protein sequence ID" value="EFI33924"/>
        <property type="gene ID" value="Dthio_PD1263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914857at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01396">
        <property type="entry name" value="FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="15310" checksum="12D831FC1230E77E" modified="2010-08-10" version="1">MKALFGDHIQLTSRVLDMRLERQNVVSSNLANVKTPGYQARRVEFEEQLQSALNLDARGKMARTDPGHVSGAFDPQGFNAQFIKSMEPRVYQGEDAVDLDKEMSIMSQNTLMYNALSMVQQKNFQGLKTVIREGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STB7</accession>
    <name>D6STB7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871282.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1272"/>
    <dbReference type="EnsemblBacteria" id="EFI33933">
        <property type="protein sequence ID" value="EFI33933"/>
        <property type="gene ID" value="Dthio_PD1272"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCBE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1022457at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="451" mass="49953" checksum="E6671E7CFB85D760" modified="2010-08-10" version="1">MKRLLITALAMIFVLGAFGQAQAIEFRAKGDWQLGINAVKNPTFDSDDEVDEFMGTTRVRTTFEFIANENLRGVMRINSNDRTWGADGIGREQGSFEYDRAYLDYFIPGTNIHMQVGKQGLTIPNTLGSHIFDDDIWAVNSFTPLHENVGLVLSWARANDMFEAGPNKNDEIDAFLTILPINMDGLQLQPFGIYGMKGQGAFANADVFPYVDGESRTSSHVYWGGINFTADLFDPLVLSGDFNYGRHSSNITGDTVGEETRGWIAALAAEYHTDHFTPELFLMYESGHSSSFTGKDGNTRGRVMPFISGDLHRVSSFGMSGSQLRGIGRAALDGYAGINSFGPSGKMAIGAGVRDLSLLDNVTHDMQLTYYQGTNHRDLRALGTEMDEIYFTTRDMAWEFTLDTQYQMYENLAAILELGYLAPSLSSGGDRDPDIQDDDAWKAATGLRFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6STG4</accession>
    <name>D6STG4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871329.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1319"/>
    <dbReference type="EnsemblBacteria" id="EFI33980">
        <property type="protein sequence ID" value="EFI33980"/>
        <property type="gene ID" value="Dthio_PD1319"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11095" checksum="8774E2940AE43384" modified="2010-08-10" version="1">MPIYEYRCNECQQLFEEWQKDFKEREVNCPICGGASSRLISNSAFVLKGSGWYVTDYCNRKSEVGNGNGKTTAKNGEAKSDNSASTSSESSTPSSQDTSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6STH7</accession>
    <name>D6STH7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1332"/>
    <dbReference type="EnsemblBacteria" id="EFI33993">
        <property type="protein sequence ID" value="EFI33993"/>
        <property type="gene ID" value="Dthio_PD1332"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="254" mass="28174" checksum="F2B7F8F47C3DAD4D" modified="2010-08-10" version="1">MQQDRDIIHIESLYKSFGDFRVLDGLDLTLEKDRVNIIIGRSGGGKSVLIKHIIGLLKPDRGRILVRGEDIVPMDEGAMARVRRDFGMLFQEAALFDSLNVHENVAFPLHEHTSKSYSEIDEVVQAKLAAVGLQGMDKKMPAELSGGMRKRVGLARALALEPKIVLFDEPTSGLDPVMAAAINELIQRTRQEFGATCIVISHDIDATMKIADNIFMLYEGKIIARGSPEELNENTDPVVRQFIRGEARGPIKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STK3</accession>
    <name>D6STK3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1358"/>
    <dbReference type="EnsemblBacteria" id="EFI34019">
        <property type="protein sequence ID" value="EFI34019"/>
        <property type="gene ID" value="Dthio_PD1358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="450" mass="51317" checksum="5CB67FE9E6F62F7D" modified="2010-08-10" version="1">MAKLLHFFLISTFPQSSRVKRTDNLYLEVLGLGGLFLFLATLNLSTDLNRYGEFMLIAAFVLSWKYWGKILVKQPLFWLMIAFALSLVISTLIGMHLFPEVRHYAEARTMARFCLFVPIAWWIGTNPASIRNAFFVVCLFFTLSSMIWILDWNTLNYFLEGNRPERGMLGPESSRLAGESILRYASWTGMLLVGASVLGKDLLPDTLRSGKIKLLGYLVFSIIIVTLMLGTYVVQARGVWIAVLISLSIGLICRYCIFQSEPKTTFNNLSIPALICLMLVAMIALNFNKIQDRFLRDQANITNLLTGQIEEVQTRSVGYRVQMYLWTLEAEHSFFGKGARAIQAINDSDKLSQKYNWEVGKTHLHSDYLAILYRLGIIGMLIATSIFCITTIQIHYKYKKRMISPSFYVFFITATIYILIAATTNINIRNHAFYAIPYATFLSIILMSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STT5</accession>
    <name>D6STT5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871450.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1441"/>
    <dbReference type="EnsemblBacteria" id="EFI34101">
        <property type="protein sequence ID" value="EFI34101"/>
        <property type="gene ID" value="Dthio_PD1441"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2001883at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="7879" checksum="F7F42B619B69B781" modified="2010-08-10" version="1">MYRSREQARRTECPFAKNGFLAAPPEVEFGPEAKMCSAEDCMMWRETREFEGRNIHPVGWCGLAGEPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU36</accession>
    <name>D6SU36_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871818.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0443"/>
    <dbReference type="EnsemblBacteria" id="EFI33127">
        <property type="protein sequence ID" value="EFI33127"/>
        <property type="gene ID" value="Dthio_PD0443"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SGW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024211">
        <property type="entry name" value="DUF3841"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12952">
        <property type="entry name" value="DUF3841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="198" mass="23673" checksum="39F012AEA43206C4" modified="2010-08-10" version="1">MILWTIQTEEAWEQLNKKGCITGVMDYIEPSWLSSYHWMMQQMKDRIGSPPCKHLFPVWAWYQWDSSNRKKPDLRSAGHLPKNVKGVRIEFSCDKNAGLLSDFTLWHYVLNYWYLPESMADDEKFDAEIKKQGTTYFEAKPHPTPKIHQKIVRSWNKIFDLDWDKTDISVPKYQKSIQATIWQLRMEQVRSCKHFKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU46</accession>
    <name>D6SU46_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SEC-C motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0133"/>
    <dbReference type="EnsemblBacteria" id="EFI32826">
        <property type="protein sequence ID" value="EFI32826"/>
        <property type="gene ID" value="Dthio_PD0133"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="860" mass="98403" checksum="6C62E8485056425B" modified="2010-08-10" version="1">MTTYQHPRTTWQAYTATLPYARDLYMQWQATMFDPDYEQALNDYILAMDQGTSDSRRQELLQQSRKNLAALKNSGDEHITTDLALIRVLSALGQTDQAAYIADLLLKNLAQNDNIPLDRPFLPPSGDFDHRPVQDTLAGWLRSALENAREPSQSISDTQEQQPPSVPAEPETPSQPKPQTQKIGRNAKCPCGSGKKYKKCCEALDTQALTQDQSHHPEPQSPVASDFTAPQASPQEPTATWSINIKGGIKVVAPADISNMNTYVLLEQEDWYEPEIEFVRALIQTGMTAMDCDTGYGVYALSIAAKMQGHGKVIALNPDPLFFESLQENRLQEIITTEPDHTALDFIRLGSSDQDMQQLCQGSPLVMFPASNELIKTFKDLNLDIYKLIPGLNALAPYQESNSALQGNLFACSKERAQILRQNNLLAASPNTTRSSSPDINGLMDNIQNDHHERPAYHPDKLELFEEDDKDLIKAYKTVVYDQQEELDLKASEAFNNLIRGYVKQARTIFNKILEKTVQNHEAQKLWLQAFNELASLRNKRPKKQKNDNIPALEQSGYKILNPAGMGWSGSGALTAYFKEFPNITFVDAGEISHIEGTISLMNLRSFQGSHGEFFKFLVLFFGFTLFGYSSSKSFKQRYGLERSKVKSRHMLDFISYAEGALHFMRLMKHIHDGNKIKYKVFKQAANLLINKICESYADEHTEYVLMDNSLHISTIHNIEYIDNMQVLCTYRDPRSNYVARVKEDWKFGPRIYKNGPVAYAESYRHFREYTGNIIENLKNNRDNVWTVQFEDFVSSEDYRQDLARKLKLDPARQDRHTHFKPWESIKNIDNYKRYENQEEILQIQQKLPQYLWEQQSNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUB1</accession>
    <name>D6SUB1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871584.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0205"/>
    <dbReference type="EnsemblBacteria" id="EFI32891">
        <property type="protein sequence ID" value="EFI32891"/>
        <property type="gene ID" value="Dthio_PD0205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7758" checksum="92CE80645164B402" modified="2010-08-10" version="1">MDYLNPLSYNYSNRRRRGFYSREPLGSTSNPLFIPKYGPAGCDLFYRPDHYPATGDTRHRMEPNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUC9</accession>
    <name>D6SUC9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0223"/>
    <dbReference type="EnsemblBacteria" id="EFI32909">
        <property type="protein sequence ID" value="EFI32909"/>
        <property type="gene ID" value="Dthio_PD0223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="8517" checksum="6CA594ABFCA31B5A" modified="2010-08-10" version="1">MWHGTDSHSIFLIIISQKYNKAAAVTAIFFNCKWLDCCKMLTSEGVLKLNAGMFIKLYIFIIYLEHQVFKKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUD8</accession>
    <name>D6SUD8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0232"/>
    <dbReference type="EnsemblBacteria" id="EFI32918">
        <property type="protein sequence ID" value="EFI32918"/>
        <property type="gene ID" value="Dthio_PD0232"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="44"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="271" mass="30139" checksum="2AE440C6377F421B" modified="2010-08-10" version="1">MQIKDGLEAHSMVAVETYRGYEDTVRACLDRIGAGSAMRRRRLIWIKPNLVNDSPFPVTSDPEMIRAVVEYVRENSRARIIIAEGCGDSGMETREVFESLGYDRLAAELGVELLDLNHEPLKRLSNPGLEFLPEIYLPKRIFSGMLISVPVLKRHSLAGVTLAMKNLMGLAPPKHYQQGGSWKKSYFHSRMQRSIFDLNCYRKPDLSIVDARVGLAQYHLGGAECSPPVNRILAGFDPVAVDAAGAKLLGLSWQDVGHIRMAHGVLGNAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUG0</accession>
    <name>D6SUG0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer membrane protein assembly factor BamD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bamD</name>
        <name evidence="4" type="ORF">Dthio_PD0254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the Bam complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BamD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871633.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0254"/>
    <dbReference type="EnsemblBacteria" id="EFI32940">
        <property type="protein sequence ID" value="EFI32940"/>
        <property type="gene ID" value="Dthio_PD0254"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1256747at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15830">
        <property type="entry name" value="BamD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00922">
        <property type="entry name" value="OM_assembly_BamD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009009751" description="Outer membrane protein assembly factor BamD" evidence="1">
        <location>
            <begin position="26"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="3">
        <location>
            <begin position="33"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="243" mass="28946" checksum="2C2D7F1335BC518D" modified="2010-08-10" version="1" precursor="true">MRIKNLLLSIILAAALAALSGCAWFQRGPEPLEDTPQELAQAGVDAMEQERYNKAIEYFSDLRDRFPFSPHTPTAEVALGDAYMKSGNYDAAITVFTEFAEMNPRHEYMPYVLFRTGLAHFNKFTSIDRPQRNMQEALEYFRRVAQVYPETEYAEYSRYYKVQCRKKIAEHELYIADFYWRTKRYGSAYERYRYVMDNFEDLPEYVEYAGERAKRSYYKHQEHVSSHKRATEEGSWRDWLDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUL5</accession>
    <name>D6SUL5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871688.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0309"/>
    <dbReference type="EnsemblBacteria" id="EFI32995">
        <property type="protein sequence ID" value="EFI32995"/>
        <property type="gene ID" value="Dthio_PD0309"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2084745at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="5">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI32995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="55" mass="6392" checksum="8FF57E30C25251D4" modified="2010-08-10" version="1">MKIKLKRSFIGMKPVQRRTLQALGFKRPNQVLEVQDNPSIKGMIKHVQSFVEVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUN4</accession>
    <name>D6SUN4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">Dthio_PD0328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871707.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0328"/>
    <dbReference type="EnsemblBacteria" id="EFI33014">
        <property type="protein sequence ID" value="EFI33014"/>
        <property type="gene ID" value="Dthio_PD0328"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="11817" checksum="B34774F8F352C601" modified="2010-08-10" version="1">MATMNSDRIRIKLRAYDNRILDKAVVEIVDSAKNTGAGVAGPIPLPTRIHKYTVNRSVHVDKKSREQFEMRVHKRLLDIMEPTQQTVDALGKLNLPAGVDVEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUR4</accession>
    <name>D6SUR4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0358</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871737.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0358"/>
    <dbReference type="EnsemblBacteria" id="EFI33044">
        <property type="protein sequence ID" value="EFI33044"/>
        <property type="gene ID" value="Dthio_PD0358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1445800at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="78"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="439" mass="49520" checksum="1E2A9963919AB623" modified="2010-08-10" version="1">MNISRIQNKTPRLSRRHFLYLAGIGSLSLATGCATHPVTGQRQFMLMSESQEIELDKENSPHQISADYGVVQDKNLQDYVSGVGRDMASRSHRPDMPYSFNTLNATYINAYAFPGGTIGVSRGILLELQDEAELASLIGHELGHVNARHTAQRMTRGMLAQVVFTGAAAAAGPQWENVVAGLGGIGTGALLASYSRNQEREADELGLEYMARADYNPEGFVGLMEMLKDMSGEDRGSLEMLFSTHPMSSERYQTAVNRVRTDYQKNSKPLYRERYMDNTARLRQIKQAVQDMQEGDDLMRAKKPGEAGEKYSSALQAAPEDYVANLKMSKYLLSRDNNSQARKYASEAREIYPEEPQAMHILGMAWLRQEKFEQSLAEFSRYQERLPGNPNTLFFQGYSYEGMGRRNQAAEKYYAFLQQVNQGDKAQHAYNRLKEWGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUY9</accession>
    <name>D6SUY9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871839.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32745">
        <property type="protein sequence ID" value="EFI32745"/>
        <property type="gene ID" value="Dthio_PD0033"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="264" mass="30922" checksum="2788FF60425B06D0" modified="2010-08-10" version="1">MPRANRYFLPDHVWHITHRCHKKEFLLKFAKDRSTWIKWLFEAKKRYGLQVLNYTVTSNHIHLLVHGHEDKDVIPRSLQLVAGRTGQEYNQRKKRKGAFWEDRYHATAVDVDEHLVRCLVYIDMNMVRARVVKHPKEWSHGGYPEIVKPQQRYRIISRDLLKRLLDIDDDLSKVYSGWVQAAVDERTPRQPGWTESVAVGCKVFVEKIKELLGGKACGRRVHEVGKTGSYALKEPVSAYNDVFGGEMGLLRSENRLFWDIYPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV48</accession>
    <name>D6SV48_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MCP methyltransferase, CheR-type</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0103"/>
    <dbReference type="EnsemblBacteria" id="EFI32804">
        <property type="protein sequence ID" value="EFI32804"/>
        <property type="gene ID" value="Dthio_PD0103"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="277" mass="32484" checksum="D4CD54BA05D09CBD" modified="2010-08-10" version="1">MTGYYFLLASRELIFDEFLKRVCPPRELNWRKYRRASRRSVLSRIYQLGLRGFFEYADYLDANPLEAAFLPNLLKVTVSRFFRETELWDHLAADILPAMAAAHPASRPLQVLHIGCCNGEEPYSVSLLWKNEIEPVFPGARISITAMDIDQTCLDRARQGWYPRKTLREVPVELQKKWFEPEDGGWRLDEEIRSMVNFTKLDLLKDHLPGQQDMVFCRYLVFTYFQGKRRREMARKISECINPGGLLILGRKESIGSQEQDLFTAVHQNLKIYKNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJZ1</accession>
    <name>D6SJZ1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869316.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3650"/>
    <dbReference type="EnsemblBacteria" id="EFI36194">
        <property type="protein sequence ID" value="EFI36194"/>
        <property type="gene ID" value="Dthio_PD3650"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1796527at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="360" mass="40358" checksum="D5A7E79A1A24DAFE" modified="2010-08-10" version="1">MIFHPPNPDEIEVSLFGPGYGECVVVHAGAGDWIIIDSCIDSRSGEVVPLRYLHKLGVEVERKVKHIIASHWHDDHTRGLSQLVEACSGARFWCPAAMTNQEFFRYVELHAETLSKQATGGTTEISRVFKLLQEKKRRRNRITPNVLIHQNQVCSAYSLSPSSDRYDDFLQNLAVEMPKVKSVQKRARVLEPNHLSAAVWIDLPDDGILLGSDVEEKNGHGWSLIFEEQTCIRTRASVFKVPHHGSSNAHHDRIWSEICNSSVNAVLSPFVRGLTKLPTLEDCKRICRLANQAYATAPPVAGGTQKYEPAVRKEFRELGIKFRAAQPKTGHIRLRGDASNGFNWSTELSPPALPLGQIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK53</accession>
    <name>D6SK53_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36256">
        <property type="protein sequence ID" value="EFI36256"/>
        <property type="gene ID" value="Dthio_PD3716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="48" mass="5726" checksum="A77817B27E2D9762" modified="2010-08-10" version="1">MLIHYCNKINQQAQARFFIGLEHAKTARFYHGDKVFMREEFFLTPCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKE7</accession>
    <name>D6SKE7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="17">BCAT</shortName>
            <ecNumber evidence="17">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ilvE</name>
        <name evidence="18" type="ORF">Dthio_PD3818</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 17">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 17">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 17">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 17">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 17">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 17">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 15">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="17"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869469.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3818"/>
    <dbReference type="EnsemblBacteria" id="EFI36350">
        <property type="protein sequence ID" value="EFI36350"/>
        <property type="gene ID" value="Dthio_PD3818"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17 18" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17 18" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFI36350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="307" mass="34625" checksum="F150B59572830389" modified="2010-08-10" version="1">MIQKTENIWFDGQLVPWDEARVHVLTHTLHYGVGVFEGIRSYKCKDGTSALFRLEEHVERLFNSARTVEMEIPFTEEAICQAIVDTLKANKMDQGYIRPLAFIGDGAMGVHPGENSIRVIIATWPWGTYLGEDALQSGIRVRTSSFTRHHVNVMMTKAKVAGNYVNSVLAKREAKADGYDEALMLDVDGYVSEATGENIFLVKHGKLKTPPLGSILGGITRDSIITMARDMGYEVTEQRFTRDELYMADEAFFCGTAAEVTPIREVDRRTIGQGKAGPNTLLFQSEYFKIVRGENMKYAEWLYDYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKF5</accession>
    <name>D6SKF5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869477.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36358">
        <property type="protein sequence ID" value="EFI36358"/>
        <property type="gene ID" value="Dthio_PD3826"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2059482at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13843" checksum="346E82825B0799DE" modified="2010-08-10" version="1">MNFFLDENFPKSAERYLVSKGHTVSDIRGSSNEGIDDLQIFRLAQEKKATFLTTDRDFFHTIPHLFPEHYGIVVIALRQPNRHAILSRLSWLVEHCKSQALFGKAYLLRESTYKVYPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKI2</accession>
    <name>D6SKI2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868327.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2599"/>
    <dbReference type="EnsemblBacteria" id="EFI35193">
        <property type="protein sequence ID" value="EFI35193"/>
        <property type="gene ID" value="Dthio_PD2599"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="13866" checksum="BC235D48433C2E61" modified="2010-08-10" version="1">MVKKFSRLREQMSSEAREKSQAKAQEMLAELPLHEVRQARGMTQKVLADVLQVKQPAVAKLEKRTDMYISTLRSHIQAMGGELDIIARFPDGSNVKIDNFSELEKDVQYNDKSRRAKTSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKJ7</accession>
    <name>D6SKJ7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35208">
        <property type="protein sequence ID" value="EFI35208"/>
        <property type="gene ID" value="Dthio_PD2617"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="224" mass="25493" checksum="1C58FA09840C5E00" modified="2010-08-10" version="1">MCGRFGLWADSRQIAEEFRLGEIPDFRPAYNIAPSQNIPAVGQGREGERSFARLVWGLKPHWFKQGGGDYKMINARAESMFDKPAFKAAARKRRCLIPASCFFEWQKQEQGAKQPYCIRPAKGDLFAFAGIWEYLEDPDSQETIYTCAIVTTRANEAVQPLHNRMPVIVHRDSYNLWLDKSVQEPRFLKAIFEPVPGRSLKIHKVGLRLNNPANDDQGLVVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKM9</accession>
    <name>D6SKM9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868374.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2651"/>
    <dbReference type="EnsemblBacteria" id="EFI35240">
        <property type="protein sequence ID" value="EFI35240"/>
        <property type="gene ID" value="Dthio_PD2651"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="128" mass="14632" checksum="E315EB69C5A8549C" modified="2010-08-10" version="1">MNNYTLVRPEHLNHHGFLFGGVMLKWVDEFAWLAASKEYRGCKLVTIAMNEIRFTEQVPNGSILRFNIEFCSQGKSSVTYDVNVYSDRPGGEQEVKVFANKITFVRVDSLGHKTPLPPRSEIKAWPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKN2</accession>
    <name>D6SKN2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpB</name>
        <name evidence="13" type="ORF">Dthio_PD2654</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868376.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2654"/>
    <dbReference type="EnsemblBacteria" id="EFI35243">
        <property type="protein sequence ID" value="EFI35243"/>
        <property type="gene ID" value="Dthio_PD2654"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="410"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="868" mass="97695" checksum="B940ADF6EBF7DD00" modified="2010-08-10" version="1">MDINKFTQKSQEAISAAQEVAMRLGHQQVEVEHLFKSLLEQEQGLVPRILQQAGYNPSSISTSLDKQLEKLPRVSGPGSQPGQIYVTQRLNSLLLKAQDLAKNMQDEYVSVEHILLSILDESPSTGAGKVIAEYKIDKNKVLSALTSVRGSQRVTSSSPEETYDALKKYGRDLVEEAQEGKLDPVIGRDSEIRRCIRILSRRTKNNPVLIGEAGVGKTAIAEGLAQRILNRDVPEGLKDKTIFALDMGALIAGAKYRGEFEERLKAVLKEVQQSEGRILLFIDEIHTIVGAGKGEGSMDAGNLLKPMLARGELHCIGATTINEYRKNIEKDPALERRFQPVMVDEPSVEDTISILRGLRERFEVHHGVRISDGSLVSAATLSHRYISDRFLPDKAIDLIDESAAKIRSEIDSLPTELDEINRKIMQLEIEQEALKREKDEASRERLEKLGQELADLKEEQARLRSRWEREKESINSLRSLKEDIERTKLEIENAERAYDLNKAAELRYGKLHQLEKELAEKESAISGDSDEEMLLKEEVGPDDVAEIISKWTGIPVTKLLEGEREKLLKLADILHERVIGQDEAVDAVADAVLRARSGLKDPNRPIGSFLFLGPTGVGKTELTKTLALNLFDTVENMVRLDMSEYMEKHTVARMIGAPPGYVGYDEGGQLTEAIRRKPYSVILFDEVEKAHADVFNVLLQIMDDGRLTDSHGRTVDFKNTVIIMTSNLGSQYLLEGISPEGHLREDARDQVMSTVKSHFRPEFLNRLDEIVLFKPLLLEEIEQIIELLLQQIRNRLQDRKISVELSDTARHFIAKEAYDPVYGARPLRRYLQQHVETPLAKEIISGRLMDGQQVTIDLENDQLSIKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKQ6</accession>
    <name>D6SKQ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868400.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2678"/>
    <dbReference type="EnsemblBacteria" id="EFI35267">
        <property type="protein sequence ID" value="EFI35267"/>
        <property type="gene ID" value="Dthio_PD2678"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034126at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10270" checksum="AA6841D8997C6E07" modified="2010-08-10" version="1">MRQDEYISATNLSKKTSATLDAFDRGEMEKMIVLKNNSPKAVLLSMEAFQAMQEELEDLRMASLALVRQETFDPKKALSHEQIMERFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKX8</accession>
    <name>D6SKX8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="3">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868471.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2754"/>
    <dbReference type="EnsemblBacteria" id="EFI35339">
        <property type="protein sequence ID" value="EFI35339"/>
        <property type="gene ID" value="Dthio_PD2754"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="61"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="BPL_C" evidence="4">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="271" mass="30298" checksum="BAFC70AB762A9475" modified="2010-08-10" version="1">MQVFKLKDILPSKVAGSFAGMPDFSACFQRSWREFRVFDLETCASSLDTAWELMDQGGMLAGDSVLCLEQTGGRGRMRRRWSSPRGNIYAALKLPVPDSTEMNRMLSIITGYSFQRALMARGIEVFLKWPNDLVVNSGKAGGILIEEKRGGILAGIGLNLKSLPDSRELRTGRLMDPVHLSGAWPEADPRTAWAELVYLGQFWYDNILCNYSLIDFISEVKPYLWLVNQMVRVEQDQIVLEGRLKGIDESGGIILDCAGHHKHIQTGTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL04</accession>
    <name>D6SL04_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanophycinase</fullName>
            <ecNumber evidence="4">3.4.15.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate</text>
            <dbReference type="Rhea" id="RHEA:12845"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13734"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137991"/>
            <dbReference type="EC" id="3.4.15.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.15.6" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868497.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2780"/>
    <dbReference type="EnsemblBacteria" id="EFI35365">
        <property type="protein sequence ID" value="EFI35365"/>
        <property type="gene ID" value="Dthio_PD2780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1485646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011811">
        <property type="entry name" value="Peptidase_S51_cyanophycinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032067">
        <property type="entry name" value="Cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02069">
        <property type="entry name" value="cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR032067-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="287" mass="30686" checksum="E15030D41761D34E" modified="2010-08-10" version="1">MEKTKGILIIIGGDMSMPPGMDNGENSSDAEVAETEGEILTRFCGLLSGIKSRIEIIPTASSIPEKAGTRYTEAFSSLGFKNCAVMEIRTREQAQSQDMVQRVREAEGFLFTGGDQLRLTTILGGTDLLNILAERYVREAVVIAGTSAGAMAMSDTMIYQGSSQEALKKGEVKFSSGFGLLSKVIIDTHFVKRGRIGRLFQAVASNPGCLGIGLGEDTGLLITKGETLEAIGSGLIIVVDGSTIKYTNMAMINEGELISIENLSVHVMVPGDKLLLSRRKFTPALAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL14</accession>
    <name>D6SL14_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin B12-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2791"/>
    <dbReference type="EnsemblBacteria" id="EFI35375">
        <property type="protein sequence ID" value="EFI35375"/>
        <property type="gene ID" value="Dthio_PD2791"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="117"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="239" mass="27630" checksum="053D7940054D1D4B" modified="2010-08-10" version="1">MEIVRTMEFDTDLVQGYYLFKIRPVTTMITSEIYNNYLQNLLKGNRQECTKIVKDLLDRDVSIYDLYLDLFQTSLYEVGYLWETNRISVATEHMATTITESVLSLAYPRIFAAQHVGRKAVVSCLVNEYHQIGGKMVADIFELNGWDGYFLGANTPVEDLLDIVRDKQPEIVALSMSVYFNMDYLHNVLQRLESELPGQQVIVGGQAFRWGGSDIQDKYSRVQYISSIKELEKMLQQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL36</accession>
    <name>D6SL36_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868529.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2813"/>
    <dbReference type="EnsemblBacteria" id="EFI35397">
        <property type="protein sequence ID" value="EFI35397"/>
        <property type="gene ID" value="Dthio_PD2813"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="32"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="24525" checksum="41976085ACA3FC1D" modified="2010-08-10" version="1">MVNNLYNLIISDVTRLCYKNCMNYYPDNSVILDVGIGNGVMLKKNHELIKKKNLQITGLDINKYYLEHCRKLINAYDLQDQVQVLHQSVTTYDPPHEGYFDYVFFGMSFMLMEDQKAVLDRAKKWVKPDGEVIFFQTMFKNRSKFMEFVKPRLKFITTVDFGKVTYENDFYALLNEENLSPCKDMLLKKNVFKGECRMIVTQPEQSVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL41</accession>
    <name>D6SL41_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2818"/>
    <dbReference type="EnsemblBacteria" id="EFI35402">
        <property type="protein sequence ID" value="EFI35402"/>
        <property type="gene ID" value="Dthio_PD2818"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="3">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="197" mass="20937" checksum="CB039C57DAB711E3" modified="2010-08-10" version="1">MKAAVSTWQDRVAPVFDVSNTIVVVDIESGAVSNRWSEYLDENDSSAKILRLAGLKIDMLVCGAISKSLCHLIAASGITVVPFVSGRVNEVIQALMDDRLNEERFDMPGRRKCFFNPEKCSFKKKEAHMPGRGKSGQGAGQPGGCAGKTGPGRGQGGGMNTSGFCACPQCGHKVEHVKGHPCYEQTCPSCGAAMSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL59</accession>
    <name>D6SL59_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868552.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2840"/>
    <dbReference type="EnsemblBacteria" id="EFI35420">
        <property type="protein sequence ID" value="EFI35420"/>
        <property type="gene ID" value="Dthio_PD2840"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10755" checksum="DE03B68DF28F77F4" modified="2010-08-10" version="1">MGLLFEWDSKKARLNLKRHGVSFDEASTAFHDPLSQTVEDPLHPGNEERFVLIGRSIQGRLLVIVHMDRGERIQIISARLATNNERVRYEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL71</accession>
    <name>D6SL71_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2852"/>
    <dbReference type="EnsemblBacteria" id="EFI35432">
        <property type="protein sequence ID" value="EFI35432"/>
        <property type="gene ID" value="Dthio_PD2852"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="310" mass="34425" checksum="C7231231E10152CD" modified="2010-08-10" version="1">MTLKTVNYFNTLIFALFLLALHIILSGPAFGQPRELTDMAGRTVLVPEEPERIVALAPSITELVFALDKEENLKGAVQYSDYPSRAEKLPRVGSYARPDVERIVRLEPDLVLAIRDGNPRQTIDRLEGMDIPVFTLDSDNLEEIMQSISALGLALNAEGRAGELVRDMQERLDQVQEKVAPAESRPSVFFQADAGPIIGAGASTFIDEMIHLAGGTNALAHKERYPRLGWEDILRLDPDVAVIASMSGGKDAHELTAAWQRWPQLRAVQQERVHVVDADVFERPTLRLLDGLEILAGLIHPQLFPDYNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLF5</accession>
    <name>D6SLF5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868648.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2940"/>
    <dbReference type="EnsemblBacteria" id="EFI35516">
        <property type="protein sequence ID" value="EFI35516"/>
        <property type="gene ID" value="Dthio_PD2940"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="164" mass="18876" checksum="320F1821B1D2E604" modified="2010-08-10" version="1">MVELVEQELCIVFLNQSHIRQLLKLEAQCFTLPWDETQFSRLMTGEHFKVLGMMECGELRGYLSFLHVRDQAEIMNLAVHPGKRQKGLGKKLMKALLGYCRIHGVQWISLEVRMSNVPAISLYQGFGFKEVGRREKYYTDTGEDALVLQLELADALKLPFSQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLI1</accession>
    <name>D6SLI1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868674.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2966"/>
    <dbReference type="EnsemblBacteria" id="EFI35542">
        <property type="protein sequence ID" value="EFI35542"/>
        <property type="gene ID" value="Dthio_PD2966"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="168888at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088233" evidence="2">
        <location>
            <begin position="32"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="323"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="743" mass="82858" checksum="74164648267863B4" modified="2010-08-10" version="1">MKPEVSFLNQSRCFLAALTAIFVFFCLSSPAAGSEDPSSDNHGLMLAGLSELEGTHGHGPSSLDDLEGDHGHGPSGLDALEGTHGHDEMAVQDDGVICPEDSVCLEAETQLPLRLLPRPFSHVYSEPAADSDNIVIANIPAFHPLFVFERRDIDMSDPASPGGWYRVGQSRDDHQGWMQAADVMEWRQALLVSYTHPGGQIEGRNPVLMFRDLDSLKELVDDFGRQDRAREIYQGIETGDVPGEIVSMEPQRFVDITKQFYILPILDWEETSIMGDDVRLLQLAAAVPEQRGADTLDDEEYSSQARIQRGDQAGAAMEDLNVDIVFTIDTTRSMQPFIDMTREAVVKMVQDFTDDTAARFRFGLVGFRDCIDTVPWLEYDVLNFTPELVDGDRLIHLLEHELEETEVGSGDYAEEGFAGVDEALRSDWRDNSLRFMVFITDASSNPKGDPQNTTGKDEHDLRREADDAQVHILAIHLLDPRATEDHPIATPQYMKLSQVRGSSESAYTSVDAFEQEEYQALVDDIVMEINDLLQKALGTDDDAAAATAQVQDEPQEVGQGQEAVGKLWEAALVEYIGQSASPPKDIVAWAMDRDLVYTADRSLEVRVLVNRDQLSSLAQALDNVIQALMRAEVTQMQFFEALQSVSSQTMQSPEDISGAGRLADTGLLPSFIQALPYKSDILSLNDEMFASMTAEQRSQLEWNILAKLEQYRAINEQVDVWFRLNETDPDREMVYPLHLDYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLV6</accession>
    <name>D6SLV6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868796.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3096"/>
    <dbReference type="EnsemblBacteria" id="EFI35667">
        <property type="protein sequence ID" value="EFI35667"/>
        <property type="gene ID" value="Dthio_PD3096"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2069856at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="100" mass="11317" checksum="76217A7FF8D68718" modified="2010-08-10" version="1">MNVFANFLMALVSVFDTLLTLYFWIVIISALLTWVQPDPYNPIVRVLRNLTEPVLHRVRTWLPFVNIGGIDLSPIVVLVGIQFIKIFVVQSLYQAVAGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM02</accession>
    <name>D6SM02_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="6" type="ORF">Dthio_PD3142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868842.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3142"/>
    <dbReference type="EnsemblBacteria" id="EFI35713">
        <property type="protein sequence ID" value="EFI35713"/>
        <property type="gene ID" value="Dthio_PD3142"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1725260at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="182" mass="20686" checksum="1769DB8D7F8A035A" modified="2010-08-10" version="1">MVSRVILNAKQMQKTLERLASQVWEQTADTETPALIGIQRRGVDLAARMQKMLEEKTGQEIRLGKLDINLYRDDWTKMTSTPVINSTKIPFSVDGKTLILVDDVLYTGRTIRSALDALLDFGRPGCIKLLVLIDRGHRELPIHADFVGKKVNTSRKEQVDVVLRERDGDDRVMLQEAENELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM12</accession>
    <name>D6SM12_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="9">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="9">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glyQ</name>
        <name evidence="10" type="ORF">Dthio_PD3152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868852.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3152"/>
    <dbReference type="EnsemblBacteria" id="EFI35723">
        <property type="protein sequence ID" value="EFI35723"/>
        <property type="gene ID" value="Dthio_PD3152"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676868at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="289" mass="33680" checksum="8799F254ABB9A888" modified="2010-08-10" version="1">MHFQDVMLNLQRFWSDYGCVLHQPYDVEVGAGTFNPATFLAVIGPEPWKTAYVEPSRRPTDGRYGENPNRLQHYYQFQVILKPSPRDIQDIYLKSLEALGIVPREHDIRFVEDDWESPTLGAWGLGWEVWLNGMEITQFTYFQQVGGIDLDPVSVELTYGLERICMYLQEVESVFDLAWNQELTYGDIHLQGEREHSRYNFELSNAEMLLGHFNNFEQECMKLCENKQVMPAYDYCLKCSHTFNLLEARGALSITERTGYIGRVRNLASRVAALYQEQRQEMGHPLMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM25</accession>
    <name>D6SM25_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nth</name>
        <name evidence="12" type="ORF">Dthio_PD3165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868865.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3165"/>
    <dbReference type="EnsemblBacteria" id="EFI35736">
        <property type="protein sequence ID" value="EFI35736"/>
        <property type="gene ID" value="Dthio_PD3165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="41"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="213" mass="23993" checksum="E9F7E897E65B9F4C" modified="2010-08-10" version="1">MKKTRIFLPREVVKRLRKSYPAPATALKWQSPWELLVATILSAQCTDVQVNKITPGLFSRWPDPKSLSMADPQEVQEVIRPAGFFRTKSRNIIQAGEIINRRFQGRVPADMEDLMSLPGVASKTANIVLYGAYGINAGVAVDTHVKRTARRLGLTRSQDPGKIEKDLMSQFEQDDWGDLNHMLVLLGRETCRARKPLCGECPLFEICPKFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM41</accession>
    <name>D6SM41_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868881.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35752">
        <property type="protein sequence ID" value="EFI35752"/>
        <property type="gene ID" value="Dthio_PD3182"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032S2G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1549871at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="17377" checksum="EFF51FB67736070E" modified="2010-08-10" version="1">MKLAELLNERKNVKEEIKKVKERLYLSAKMQEGDTVPVEPPEDLKNELIRLYERLNELIILINKTNMTTMESGKSLMELIAERDKNTGIAEILHRLADSATPKSERFSRNEIRFIPAVDVKAIRKEADSYARIAREIDNQIQAANWNIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM63</accession>
    <name>D6SM63_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868903.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3209"/>
    <dbReference type="EnsemblBacteria" id="EFI35774">
        <property type="protein sequence ID" value="EFI35774"/>
        <property type="gene ID" value="Dthio_PD3209"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12055" checksum="25938B02B3AD72A7" modified="2010-08-10" version="1">MAGILRGEIYWADLNPVTGQEQGGLRPVLVLSHNVFNERSGTVIAVAITSQPQRAGFPLTLELSDTELPKRSWAKISQVRTLSTKRIGKKIASASSEELVSIIDGLNEIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM69</accession>
    <name>D6SM69_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin:thioredoxin reductase</fullName>
            <ecNumber evidence="5">1.8.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ferredoxin-thioredoxin reductase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD3215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42336"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ferredoxin thioredoxin reductase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.2" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868909.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3215"/>
    <dbReference type="EnsemblBacteria" id="EFI35780">
        <property type="protein sequence ID" value="EFI35780"/>
        <property type="gene ID" value="Dthio_PD3215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1872656at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004209">
        <property type="entry name" value="FTR_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036644">
        <property type="entry name" value="FTR_bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35113">
        <property type="entry name" value="PTHR35113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02943">
        <property type="entry name" value="FeThRed_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57662">
        <property type="entry name" value="SSF57662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="110" mass="13134" checksum="8CD1311E505C40AF" modified="2010-08-10" version="1">MTPEQLYETLQKIQEPKGYFFNRDREMVMELLQSLIYNRDHLGYMACPCRLASGDRDQDRDIICPCVYREPDVQEYGSCYCGLYVSKEWNEGEIPREYVPERRPPEKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMA3</accession>
    <name>D6SMA3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">Dthio_PD3249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868943.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3249"/>
    <dbReference type="EnsemblBacteria" id="EFI35814">
        <property type="protein sequence ID" value="EFI35814"/>
        <property type="gene ID" value="Dthio_PD3249"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1345271at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="15"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="304" mass="34475" checksum="236740D39E87313F" modified="2010-08-10" version="1">MQVVTQTSITEFPLISRGKVRDIYELDPDTLLIVTTDRMSAFDVVMSQPIPYKGAVLNQITLFWMDMFKDLVDNHLISSNVEDFPEPLKPYSEELRGRSVMVRRAAPLPIECIVRGYITGSGWKDYQRTGQVCGYTLPQGLVESQKLEEPLFTPSTKAEAGAHDENIDMKQAGEKIGQEMLQQVQELSLSIYGQAREYAEKKGILIADTKFEFGTRDGRIMLIDEVLTPDSSRFWPADTYKPGQGQSSFDKQYLRDWLERSGWNKNPPPPDLPEEIINETTKKYLLAYKLLTGKDLMQGGTYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMB1</accession>
    <name>D6SMB1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SEC-C motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35822">
        <property type="protein sequence ID" value="EFI35822"/>
        <property type="gene ID" value="Dthio_PD3258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="686" mass="79476" checksum="D2CDDED8FF792C56" modified="2010-08-10" version="1">MINGKLIERLRKTDRCAPSVSELARDLAQMPSQDLTDLMQKLIYDGEDKALGIMLNAVAWERMRFDPQVLCQSLKVVDNLDDFIYPFRDQDEESIGPLLDLATARDISSQRNVLAAVLAAELSIRSGTRNQEVKKVLTKMQHGLLLPETRVYIQAALNMLQDNDWLSKSLPILVEKDIHEELPRSRAPSYIGRSQTVRRPVAKISRNAPCHCGSGKKYKKCCLEKDEELLHDASPYAGLTMSQVMASPDLVEDTGVIDNMRAYQLKKVDPEKLNPRQLLAAYRKAVSFGLLETGYNMLLELKGRPEKEQFALERMHDLEQEALDDGNLELSKLIRSHLPEDEPDYACRDFHMFLLENKDLFMEMEKYCQNVLSNQDDFFNYNPVDFAFCFEKLFPALSIIFIRSALLDERGSFLDSKFLMNVLRSSRADLDLDPLDDPVEDYLEWSMDKFEQDVDLEAKDREIQELKQQISEGRRDALRQERELRDKERELENLSERLEKENRLKKTGGAEQAQSQDRTGEQADVAHLKRRIERLKMEIKEQQNERSRLRSQLESKQKEKYKTQDQAGQDKEKSEDVEQEPAQEDGLAVNKVFIPVYTEQFRKSCENLPAGIVAKALRAAAGFASHHRDTLRQSKRLERLSSVYRVRIGLYHRLMIRYEKDELQVLDLIHRQELEKWIRQYSGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMB7</accession>
    <name>D6SMB7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868957.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3264"/>
    <dbReference type="EnsemblBacteria" id="EFI35828">
        <property type="protein sequence ID" value="EFI35828"/>
        <property type="gene ID" value="Dthio_PD3264"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="26"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="374" mass="41027" checksum="83554855282ABDC2" modified="2010-08-10" version="1">MKVQVKVLVLSLVMTMFLGLGSAWAEIRIGLMAPLTGSWASEGRDMRDIVQLLADEVNAAGGINGQEVHLRVEDDGGDPRTAVSAANRLATRDVTAVIGTYGSSITEATQNIYNDFGVIQVANGATSVRLTQQGLNYFFRTCPRDDEQGRVAAETIDEMGYNSVAILHDSTSYARGLADEARALLEQDNKEIVFFDALTPGERDYSTILSRLRNAEPEIVFFTGYYPEAGMLLRQKNEMNWNVPMLGGDATNNPDLVSIAGTASAKDFYFLSPPVPQDLETPQATEFLSSFNEIHDSNPGSIWAVLAGEAFLVLTDALEATGSTDRDVLADYMRDELEIDGLTGTISFDEYGDRYGELYRLYQVDDEGNFVMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMC1</accession>
    <name>D6SMC1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868961.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3268"/>
    <dbReference type="EnsemblBacteria" id="EFI35832">
        <property type="protein sequence ID" value="EFI35832"/>
        <property type="gene ID" value="Dthio_PD3268"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="235" mass="25793" checksum="6555430D1B958BC7" modified="2010-08-10" version="1">MLLSVKDLFVNYGNVEALHGINLNVREGEIVAMLGANGAGKSTTLMTISGLINPVKGSIFYNNMDITTMQGHDVVAQGIAQVPEGRRVFSTLTVQENLDLGAFTMTDKDRINRRLEWNFELFPRLKERKDQLAGTLSGGEQQMLAIARGLMAHPKLLLLDEPSLGLAPILVKSIFEKIKEINAEGLTVLLVEQNARAALKLAHRGYVMEVGRIVLEDSADKLLKNPDVRKAYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SME6</accession>
    <name>D6SME6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M29 aminopeptidase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868986.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3296"/>
    <dbReference type="EnsemblBacteria" id="EFI35857">
        <property type="protein sequence ID" value="EFI35857"/>
        <property type="gene ID" value="Dthio_PD3296"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="689314at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="402" mass="46379" checksum="3AB535EB35A12F56" modified="2010-08-10" version="1">MFTQQELEKYAQVMFWGMRKARKHPFAPGDIVLIRSDLSCIPLAHELFRMFLQQQYHPVLRLIPPEEIEKTFFTMAHDSHLDFQLPGDRELYSSLNGMISLLGPQSLTHLRDIDPSRIGRFAVAKKYLRDILERRESQGSFGWSLCLYPTDELAAKAGLTLEEYKNQIVQAVYLDKDDPVFIWEDIFEQSKRIKEWLDSMDVEYFHVLSKNTDLKVYPGEKRRWVGLSGHNIPSFELFLSPDYRKTQGVFFSDQPSYRSGNLVRGVRLEFKDGRLQEISAEEGEEFLKKQVRMDEGASMVGEFSLTDKRFSRISSFMAHTLFDENFGGDNGNCHIALGASYADTFAEDSSQLTPELKEEMGFNDSALHWDLVSTEPKEVHAYLKSGEVLTIYRDGQFTITDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMK1</accession>
    <name>D6SMK1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Dthio_PD3352</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869040.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3352"/>
    <dbReference type="EnsemblBacteria" id="EFI35912">
        <property type="protein sequence ID" value="EFI35912"/>
        <property type="gene ID" value="Dthio_PD3352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="18">
        <location>
            <begin position="366"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="438"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="516"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="584"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="829"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFI35912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112306" checksum="777D6D071F820A84" modified="2010-08-10" version="1">MKLFTRGISLKAALLALFAVVTVAAVALVGLFSYYTGKRAVNDVALQLRAEVVERINEHVQDYLLLPHQINHVNARAIALDNGLAQDQEALSARFAEQVDLFPTLTSISFGNALGGLANSGREPRNDSRYVIVTDRFQAGTFRKIALDSDARQDREIDVLTEFDARTRPWYKLAQDKGGPVYSDIYILFTGQDMSLAASSPVYDRQDNFLGVLSIDLFLGHLSEFLRDLDIGNQGQAVIMERSGDLVASSKGRVLMVDKVPSLSRRVQGVESEVPAVREAVRSLMFRFEDLDAIQEDHFLDFKVQGRKHLLQVSSLKVDPGIDWLVAVSMPEEDFMAGFAAQNRITILITLAVLGLALLAGMFVTRGIVRPVSLLERAAGRLTSGYQPEEIAEKSRFVEVRNLTRSFNQMSRKVSDSILKLNNELAERRRAEESLRESQERMQAVTDSAHDAIIMMGPDGEISYWNPMAESIFGYTAQEVMGKSLHHLLAPERYHTDITKAMPEFQRTGQGNAVGKTIELSAIGKDGLEIPISLSMSSVLLQGRWHAVGIARDISRRKAAEKELIQAKEQAEAANIAKSKFLANMSHELRTPFNGIMGMMQLLQTTDLNDEQQEFVNLAIQSSERFVRLLTDILELSNIEAGKMSICSAEFRTGELLESLSDLFSAEALKKGIVLEFSMEPDVPEQVSGDKTRVKQVMFTLVGNALKFTESGSVQVHLTSISGAKGGDTRLKFSVSDTGIGIPDDKLSTLFNPFVQVDGSYTRKYQGAGLGLSLVKRLVDMMNGNISVESEVDRGTTVHVVLPFTLPAVDHLESVTAATTKPESKKYLDILLAEDDRLNQLFMKTMLEKQGHNVLLANNGQEAVDLFQEQNFDCILMDIQMPVMTGVEATQRIRSMEQGAWGPSETPVYDREPFGLFHGAGMEHGAEVRGQRSEIRDERPTAEVRIPESLNSSIPQSPNPRIPIIAVTAHTQPGDRERFLEAGMDDYIGKPVNNEDFQRVFSKFFGQEHLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMN5</accession>
    <name>D6SMN5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869074.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3388"/>
    <dbReference type="EnsemblBacteria" id="EFI35946">
        <property type="protein sequence ID" value="EFI35946"/>
        <property type="gene ID" value="Dthio_PD3388"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2212512at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="67" mass="7911" checksum="50C5E9B953CA6F54" modified="2010-08-10" version="1">MSGFSGEKLVNSIKTAVLDRQKKLQENMPEIERNLYHYAGKMGIKPEDIQRTRDRIKDRIHKARKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMP7</accession>
    <name>D6SMP7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar biosynthesis protein FlhF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Flagella-associated GTP-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869086.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3400"/>
    <dbReference type="EnsemblBacteria" id="EFI35958">
        <property type="protein sequence ID" value="EFI35958"/>
        <property type="gene ID" value="Dthio_PD3400"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1162441at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020006">
        <property type="entry name" value="FlhF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF3">
        <property type="entry name" value="PTHR43134:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="163"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="12">
        <location>
            <begin position="164"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="367" mass="41511" checksum="520DAD3D17082321" modified="2010-08-10" version="1">MQVKTFRGQSYSALLQQVKSELGPDAVILSSDCISSNGKKAFELTAALEVPAADQEQAYDKKQEKSGSEDLIPDTEPGLQGEQWRQEWAEFKKSIFQMIKPQLQGPRISSRQKQALEFLEKQGVYPEVIMDLWSRLGKNSHLPTLDVLSRAVPVSSWKKQMRQGTIHCLMGPSGVGKTTTVLRLALESRNIKPGMKICLVNNDTQHAGGRLFLKHYADLSGFSFMEIKSAQDLKSLKQAREKFDLVFMDTPGLGPHDNVQDSLWMKHMKNIQRHLVLSPVYAHEQLDNYLQKYSRDDLNSLIWTKLDEACSYGTLVNASWKSALPASYLGFGKGLRHCSTSASRDNFWKLIFKKKLPQATQQEDNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN01</accession>
    <name>D6SN01_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869190.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3506"/>
    <dbReference type="EnsemblBacteria" id="EFI36062">
        <property type="protein sequence ID" value="EFI36062"/>
        <property type="gene ID" value="Dthio_PD3506"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031TWH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1118176at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="355" mass="40469" checksum="2F0692FF4F50AAAF" modified="2010-08-10" version="1">MDIAGKKIWQVAAGDTDRNYTDLCLYWDVIVNGPGSEGRWPECENKLRQEWELSSRKISDLRRFAEEMTDGDLVVLRMGTTDVLGVGVVVGEYLWNEEFGDVDGWDLQHVRRVKWLWKYDGTPKRFDTYTLKFGDTVQSIDSQPVMDWVHSFSAEILSTKRPLTRLPDPSKDVGWEDIAEYLFDHGVASNAIGKITNEIDELVRISKWYQRTGGPSEAETVAYLAIPLLRSLGWTPQKMAIEWGGVDIALFSTLPRVDNNLTVVVEAKQKGYACLNAQSQAKTYAEQEGRTDCNRLIVTDGLRYGVYFRQDGKFPNEPHAYLNLTRMRNAYPLLKCKGAKEAFLFMSADWVPQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN10</accession>
    <name>D6SN10_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869199.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3517"/>
    <dbReference type="EnsemblBacteria" id="EFI36071">
        <property type="protein sequence ID" value="EFI36071"/>
        <property type="gene ID" value="Dthio_PD3517"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="138" mass="15560" checksum="1F7999BFC792714E" modified="2010-08-10" version="1">MITIADTGFVVGVAISTDKWHNECLNLYLKQSAVVLPQTVLAEVAYLITRAGGNLVMSKFLKNFSRTKYRLMALDSADISRSAILLEQYADTRIDFVDSTVVAMAERLNIQTILTTDHRDFRIVRPQHVNSFDIQPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN19</accession>
    <name>D6SN19_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869208.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3527"/>
    <dbReference type="EnsemblBacteria" id="EFI36080">
        <property type="protein sequence ID" value="EFI36080"/>
        <property type="gene ID" value="Dthio_PD3527"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZB6I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="493269at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045941">
        <property type="entry name" value="DUF6361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19888">
        <property type="entry name" value="DUF6361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="412" mass="46908" checksum="C626FC94098872C7" modified="2010-08-10" version="1">MFNTSVNPLQIGWIDYSPEHRRKVMTVLQSLAAPGAVDEIGIGQIRDGFSHKLFPGTSTIQTRAKYFFLVPYILMELEKQKNITPNALIQKLNDMELELIEPLLKSGEKGVIGETAGKNLKRKPSSVYWSGLKTFGILRYPHLSLEDYARAVCAVRKENLDIRSMGVSEDVSSQGDDSDAAGTSLTGGFWRCPPPPENWREHISIHLTYEEALHLKQCIIRSSFSKDSLLAFLLQVEPEVFTALEDFGAIGEALELPESIRQDFEMARDFSRFIFGASLRYNLILSEGRNEKARQLWTEWLSSYFVTQRFEHYEPVAPMDYLQISNPALRRFLTQWKKYVLAGNEEDMDSLIVQREIDLKGRQRAKLRNSALYSYKVGDGLRGGKLDFRYSYARDILTDIFKALEGSHAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN21</accession>
    <name>D6SN21_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3529"/>
    <dbReference type="EnsemblBacteria" id="EFI36082">
        <property type="protein sequence ID" value="EFI36082"/>
        <property type="gene ID" value="Dthio_PD3529"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZF2C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036782">
        <property type="entry name" value="NE0471-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143880">
        <property type="entry name" value="SSF143880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="18985" checksum="C4E12D518F789227" modified="2010-08-10" version="1">MNKKHFRINSVEPLPDYKLRISFADETTFELSLAEWIKTSRALSPLKDPELFAKARVGFAGASVEWVQDELDLAADNLRNLAVEQAGGIGHERIRNWLHETGLTLNQAADALGISRRMLIYYRDGEKPVPRHIWLACLGWEATRPKDPKLLPERIPSVQEYAAIHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNE1</accession>
    <name>D6SNE1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869595.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1618"/>
    <dbReference type="EnsemblBacteria" id="EFI34267">
        <property type="protein sequence ID" value="EFI34267"/>
        <property type="gene ID" value="Dthio_PD1618"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50338B3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1841610at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="12879" checksum="01274F0CF3425F9A" modified="2010-08-10" version="1">MSKLFVVLLDDKRMEALKGSGLEDKVEYMFGGNLRAFTMEMPDEKANAIMKEFDTARTDSRGCITDTPLAFNRTLFEEIAKAKSLGPEVVDNTLARAGEIKELAAKESDYLPAPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNH1</accession>
    <name>D6SNH1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="7" type="ORF">Dthio_PD1648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869625.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1648"/>
    <dbReference type="EnsemblBacteria" id="EFI34297">
        <property type="protein sequence ID" value="EFI34297"/>
        <property type="gene ID" value="Dthio_PD1648"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="128" mass="15049" checksum="4CCB68864E55E9C9" modified="2010-08-10" version="1">MGSLNFPRHLRLVRRPQFQACYAGGRRYQTKHFIIFVRPNGRDYWRLGITASRKIGPAVLRNRIKRLVREAFRLNQHLVPPGLDYVVVSKKRTDLPGLNLDMVQKQLMQLFQQIAPRTEKDLEQDPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNQ2</accession>
    <name>D6SNQ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1730"/>
    <dbReference type="EnsemblBacteria" id="EFI34378">
        <property type="protein sequence ID" value="EFI34378"/>
        <property type="gene ID" value="Dthio_PD1730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="43" mass="4985" checksum="8776CDFAEE1F3E9E" modified="2010-08-10" version="1">MDIDQVLDDCKRILKEHYEHGGFGEWSWAVSRLPGEVLDVLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNT9</accession>
    <name>D6SNT9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869737.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1773"/>
    <dbReference type="EnsemblBacteria" id="EFI34415">
        <property type="protein sequence ID" value="EFI34415"/>
        <property type="gene ID" value="Dthio_PD1773"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YQV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1997676at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="9970" checksum="20FD03B50E8C9F57" modified="2010-08-10" version="1">MKADEFDKKFDKGNEDIVEDLDLSTARRVNQEQRRINVDFPAWVVESLDREAARIGVTRQSIIKVWLVERLKAEAADKPVNGDAAGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNU3</accession>
    <name>D6SNU3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869741.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1777"/>
    <dbReference type="EnsemblBacteria" id="EFI34419">
        <property type="protein sequence ID" value="EFI34419"/>
        <property type="gene ID" value="Dthio_PD1777"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337YA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1820646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036782">
        <property type="entry name" value="NE0471-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143880">
        <property type="entry name" value="SSF143880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="11880" checksum="1CE49C613FEB1AE5" modified="2010-08-10" version="1">MIKDVVSAIYKGGYKIEVTFEDGLTGIVDFSRYLNQGGVFEKFRDIEFFKNFRINKELGVLTWGDEEVDIAPENLYAEATNTPLPEWMNPQQGSSENLTYQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNU8</accession>
    <name>D6SNU8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869746.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1782"/>
    <dbReference type="EnsemblBacteria" id="EFI34424">
        <property type="protein sequence ID" value="EFI34424"/>
        <property type="gene ID" value="Dthio_PD1782"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="160" mass="17932" checksum="BA30AABBB0E329AC" modified="2010-08-10" version="1">MSQPDSRGFSWMQMPARRESLHPIQEFVLKEASVRGMPGDVLQKIELVLEEVLLNIINYAYPETDSGEVQTGCREQDSGDFQIRIMDHGAPFDPLKRPDPDTGRPVQHREVGGLGIHLVKNMADRVEYTRQDGRNILDIVFNAVSSPGHKPAHKDASTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNU9</accession>
    <name>D6SNU9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869747.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1783"/>
    <dbReference type="EnsemblBacteria" id="EFI34425">
        <property type="protein sequence ID" value="EFI34425"/>
        <property type="gene ID" value="Dthio_PD1783"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="109" mass="11872" checksum="DAF1F6FCF3924C83" modified="2010-08-10" version="1">MEINSKKVDQVLVISVSGRLDTTTAQEFESSCLELVKDESRIVVDLQEVEYVSSAGLRGILSVGKTVRSNGGGLVFCCLRGMVKEVFEISGFASIFSIYDTREQALESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNX2</accession>
    <name>D6SNX2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="14" type="ORF">Dthio_PD1807</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869770.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1807"/>
    <dbReference type="EnsemblBacteria" id="EFI34448">
        <property type="protein sequence ID" value="EFI34448"/>
        <property type="gene ID" value="Dthio_PD1807"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="2"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="882" mass="98295" checksum="6C4B3FF23475F848" modified="2010-08-10" version="1">MLSAAEIREKFLKFFQDNHHTVVPSSSLIPADDPSLLFTNAGMVQFKKVFLGQEKRDYTRAVTSQKCLRVGGKHNDLENVGRTRRHHTFFEMLGNFSFGDYFKERAIDLAWTFLTRELGLERDKLFITIFADDDDAHGLWQEVAGVSPDRIYRLGEKDNFWSMGDTGPCGPCSEVLYDQGEGMSCGPDCAIGVCDCDRYLEIWNLVFMQYDRDQEGNLNPLPRPSIDTGMGLERISAVCQGVYSNYDTDLLKSLITDTARKSGKEYGRDRDDDVALAVIADHARSSAFMIADGILPSNEGRGYILRRLIRRAFRFGRHLGLAEPFLHQTVQVVVQDMSMAYPELEKGRDFMVRVIRQEEERFSETLEKGLVLLEEELKKLESLQVNTVPGETAFKLYDTYGFPLDIVNDIAEKRGFSVDEAGFQECMQDQRQRARAAWKGSGDAGLGEVLSSLEGELPQTSFVGYDRLQDQGEIVLLVDQEGRSREALSQGEKGWLVASRTPFYAESGGQVGDRGRIQAARGQAMVRDTQDQAAGVVAHEVEVSRGEVHKGDVVDLTVDEGRRVATARNHTATHLLHLALRRVLGEHVHQAGSLVDEKRLRFDFTHIQALTAEEMERIEEEVNAAILSDYQVQVRVMDYSQAVQEGAIALFGEKYTDKVRVVSVGNISMELCGGTHLDSTAQAGTFCLVSESAVGSGMRRIEALTGWDALNYWRGMRKSVTSLQETLKVAPDQLVDKVQALQEQMRELARENKALSQKISAEQGRDIASEKKMVGRVPLVARKVDVGDVEGLRSLMDDIRSKLDTGVAMLGTRNKGKPTLLLYVSKDLHENFTAPELIKEVAKEIKGGGGGRPDLAQAGGSDAQGLDRAIERLEEILAERMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNY9</accession>
    <name>D6SNY9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen-fixing NifU domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869787.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1824"/>
    <dbReference type="EnsemblBacteria" id="EFI34465">
        <property type="protein sequence ID" value="EFI34465"/>
        <property type="gene ID" value="Dthio_PD1824"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="139" mass="15219" checksum="D2B3EA13D47CE118" modified="2010-08-10" version="1">MEESMHKAFDELQEKVDSQALQDFGPEVYRRWKNPDYMARMQNHDCMAAVTGSCGNRVEIYLVLEQEVIARATFFSEGCGSSVVCASMTCELARGRTLDQALALGAGDVMQALPGMPGSKKHYAALAVKALHRAIETCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP42</accession>
    <name>D6SP42_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869839.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1884"/>
    <dbReference type="EnsemblBacteria" id="EFI34518">
        <property type="protein sequence ID" value="EFI34518"/>
        <property type="gene ID" value="Dthio_PD1884"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="107" mass="12796" checksum="28CFE55F3B9B4F41" modified="2010-08-10" version="1">MIRIPKYREPTHPGQMLMEDFLAPLSITQRDLSKAIHVPYQRINEIVNGRRGITPSTALRLAKFFDMSEDFWMNMQLRWDLYRAKKSEERELRMIKPYTSSEHTAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPA1</accession>
    <name>D6SPA1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869897.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1949"/>
    <dbReference type="EnsemblBacteria" id="EFI34577">
        <property type="protein sequence ID" value="EFI34577"/>
        <property type="gene ID" value="Dthio_PD1949"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1305058at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010415">
        <property type="entry name" value="LpxI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043167">
        <property type="entry name" value="LpxI_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041255">
        <property type="entry name" value="LpxI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06230">
        <property type="entry name" value="LpxI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17930">
        <property type="entry name" value="LpxI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LpxI_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="LpxI_C" evidence="1">
        <location>
            <begin position="137"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="279" mass="30217" checksum="BFBEA453C26111D5" modified="2010-08-10" version="1">MAGSKKLGIIAGGGSFPLLVAQNARKQGYRVAAAAFEKETLPEIQAYTDQLVWLKLGQLGRLIRFLHQAGVSHVVFAGPINKPRAFDLRPDFRAIKLLVNLRSRNDNALLSSVADELHREGLEVISAIEFVPELISPAGLQSRRAPSFAEKKDILFAWPIIKQIGSLDIGQCIVVKERAVVAVEAIEGTDRAILRAGELSGSSLTVVKIFKPGQDQRIDLPALGSQTVRTMIQAGATCLAYESGTSLFFDRAEAVSLADEHKICLVGIDPDNPEAVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPA3</accession>
    <name>D6SPA3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="9">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="9">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fabZ</name>
        <name evidence="10" type="ORF">Dthio_PD1951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1951"/>
    <dbReference type="EnsemblBacteria" id="EFI34579">
        <property type="protein sequence ID" value="EFI34579"/>
        <property type="gene ID" value="Dthio_PD1951"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="155" mass="17602" checksum="43BAC95EBB29F369" modified="2010-08-10" version="1">MNQVPGTEMSIQDILNFLPHRYPFLLVDRVVQLEPFKSLKALKNVTINEPFFQGHFPDYPVMPGVLILESLAQAGGLLVAGSVPDQMQGKIFLFTGVDKVRFRKPVFPGDSLYMHITYDRHRMNLWRMHGQAVVQDRVAAEGMFSATIVDREDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPB1</accession>
    <name>D6SPB1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869907.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1959"/>
    <dbReference type="EnsemblBacteria" id="EFI34587">
        <property type="protein sequence ID" value="EFI34587"/>
        <property type="gene ID" value="Dthio_PD1959"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="485527at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="92"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="278" mass="29801" checksum="13D7A2E612EC0701" modified="2010-08-10" version="1">MSFELPRIPLGDGIEAALDFLVDHLALATRAFSAVADQGLRFIETSLLGVHPVIVIVIVTALVFFMTRKRGVTVFTFLGLGLIWNMGLWTATASTLSLVVVATLIAIAIGIPLGIIAGLSDWVYRIVRPILDFMQTLPAFVYLIPAIPFFGLGKVAAIFATVVFSMPPAIRFTNLGIRQVPKELTECADAFGADRWQKLFKIQLPLAKTTIMGGVNQTVMLALSMVVIAAMIGAGGLGGEVWRAIQRLQPGAGFEAGIGIVILAIILDRLLQSLASKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPE9</accession>
    <name>D6SPE9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869945.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1997"/>
    <dbReference type="EnsemblBacteria" id="EFI34625">
        <property type="protein sequence ID" value="EFI34625"/>
        <property type="gene ID" value="Dthio_PD1997"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="137"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="350" mass="39008" checksum="E01D0B27881ED267" modified="2010-08-10" version="1">MLKHLFKEITRRPMGVACLAILAALYLGTVFSQFLAPYLPTDQDLTSAYHPPTRIVLEDWRPHVQVYEQVDPAAARYEPVEGETAPIKFFAAGDEYRFWGLIPAQMRLFQVEEPHRIYLLGSDGTGRDVFSRLLYGAQVSLSIGFIGICITMTLGFLVGGIAGYFGGRTDFLAMRLVEFIIAVPSLYLLIALRGALAEHFEPEQMYLVIVIILSLIGWAGAARIIRGMALSLRQRPFVLAAEVMGQSSLRILFRHFLPNLASYLLVAATLSIPAYILAEAALSFLGLGIQEPGTSWGLMLQQAQELKVFTLNLWWLLTPGAAIFITVITFNMLGDVLRDIVDPRQQMVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPS4</accession>
    <name>D6SPS4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KilA-N, DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870068.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2126"/>
    <dbReference type="EnsemblBacteria" id="EFI34750">
        <property type="protein sequence ID" value="EFI34750"/>
        <property type="gene ID" value="Dthio_PD2126"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1578471at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018873">
        <property type="entry name" value="KilA-N_DNA-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10543">
        <property type="entry name" value="ORF6N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORF6N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="179" mass="21073" checksum="A5CD76EA715216FD" modified="2010-08-10" version="1">MSDLIPLEAITAKIIVLRGMKVMLDRDLAELYGVETKVLKQAVRRNIKRFPEDFMFKLSKQEVMNLRSQFVTSRWGGARYYPMAFTEQGVAMLSSVLNSERAVQVNIQIMRAFTRLRRMLADNEDLRRRIEEMEAKYDEQFRLVFEAIKQLLSEEEKTGPKIGYLREEVEKYPQQEPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPY4</accession>
    <name>D6SPY4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870126.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2193"/>
    <dbReference type="EnsemblBacteria" id="EFI34810">
        <property type="protein sequence ID" value="EFI34810"/>
        <property type="gene ID" value="Dthio_PD2193"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2112017at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="227" mass="25418" checksum="E93A4D9C49A9B3BA" modified="2010-08-10" version="1">MSLFGKIFKRTPESLQLSDWLANMTEAFLRMGDDTLGRDKASPDMLVCFTLINATHTAHNLLHTDPRIASNIGPIYAELRAYYECLWQLILLHQYSTPDEHDKISRLCGDVALRLERTMESLFKSNPNVKRALSEATGAAYERVMVNAVNEYIHGERAHAFPESGDHISDNIRALSGRIQRLGGLDSSQSGAVYEVLSQATSKAPSMTFLTQFNFSACKVLPDAFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPY5</accession>
    <name>D6SPY5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34811">
        <property type="protein sequence ID" value="EFI34811"/>
        <property type="gene ID" value="Dthio_PD2194"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZDPR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="235" mass="28008" checksum="0348BA66424CB963" modified="2010-08-10" version="1">MKALAFIVVDQDYIPGKIVDIDLEILLKIRKKNLWPIDEHIKQYSEDDLFDIIEFLHIHVSKPVDGTYHNWNNCGMHWETFNKIEGQSEFRQKINELLNMYSKTFELSEKGEILHKPEVGFEKIFEADIPSQDQNVTDRISSAILRYRRHGSTMDDRRQAVRDLADVLEYLRPKVKSILTKEDEKDLFNLANNFGIRHHNEKQKTDYDTSLWLSWMFYYYLATIHVLLRKINMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPZ7</accession>
    <name>D6SPZ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2211"/>
    <dbReference type="EnsemblBacteria" id="EFI34823">
        <property type="protein sequence ID" value="EFI34823"/>
        <property type="gene ID" value="Dthio_PD2211"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YHH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2039087at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="9563" checksum="7743C11CA0B164B8" modified="2010-08-10" version="1">MKTTKYFKATRIRPDRKIIKDEWIQYVVQHPEREQIQTDGRIKRWARIEEMEGRYLRVILLADGETIHNVFFDRGFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ43</accession>
    <name>D6SQ43_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/carnitine/betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870183.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2260"/>
    <dbReference type="EnsemblBacteria" id="EFI34869">
        <property type="protein sequence ID" value="EFI34869"/>
        <property type="gene ID" value="Dthio_PD2260"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1217683at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018093">
        <property type="entry name" value="BCCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01303">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="501" mass="55133" checksum="FBA1D20F4135E90F" modified="2010-08-10" version="1">MFKDTVFVASLIIVAGFVLLGIFDQELLDSISTTIHGGIIANFGWAYLLVTFFFLVFCIVLALSKYGNIKLGKDEDRPEYTYFGWFSMLFAAGMGIGLIFWGVAEPLSHYMQPPEHIEKESGQAATFAMRYSFFHWGLHPWAVYIIMSMSIAYFSFRRDMPPLISSCFYPLLGDRIYGLPGKLIDILAVFATIFGIATSLGLGALQINSGLEHIYGLPATDTSTLLIILVTTLLFMISAAVGLDKGIQTLSKSNMFLAFLLVVFMLIFGPTAYIMTVFTDTMGGYLSDVLEMSLTVNPFLGHEWYKDWTIFYWAWWIAWSPFVGIFVARISRGRTIREFISGALLVPTLLTFIWFAVFGGSSLYLELEAGAAVGGAVLDDVSTGLFAVFDHYPGSIILSNAAILLLVVFFVTSADSATFVLGIMTSRGSLNPSLGKKIVWGVTQSSVAAILLVSGGLVALQQMAITAALPFSFVLLLMCYNLWRGLSAEAKEGLNSRFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ77</accession>
    <name>D6SQ77_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34903">
        <property type="protein sequence ID" value="EFI34903"/>
        <property type="gene ID" value="Dthio_PD2294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="41" mass="4618" checksum="694BBA95492882B7" modified="2010-08-10" version="1">MQVSVKYSKKQDQNHCRNISLGVTIQGGLARRTVPVLHAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ95</accession>
    <name>D6SQ95_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type IV pilus secretin PilQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial secretin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870235.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2312"/>
    <dbReference type="EnsemblBacteria" id="EFI34921">
        <property type="protein sequence ID" value="EFI34921"/>
        <property type="gene ID" value="Dthio_PD2312"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013355">
        <property type="entry name" value="Pilus_4_PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02515">
        <property type="entry name" value="IV_pilus_PilQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088023" evidence="7">
        <location>
            <begin position="30"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="8">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="569" mass="64037" checksum="DCEA32161D986036" modified="2010-08-10" version="1">MLKKNLMLLSALLMLTAGFALLISQSALAETPPEDLNAQNTIQEIDFWVDQDKTLHVQLLGQGPFSHTVTDREQDRMHILLPESRAAEKLVRLYRLNEMDTSLKSLLLRNTDEGALLTWVWSSEPDFSVQEAEDELLFQIAPGSDAPGAAPAGAGLATLEQEAGELMQDSLFPGMREEYTGEPVSIDLQNAEVEHVLRLITHHTEYNLILDEEVQGKISLRLREVPWDQALDLVLAQKDLGMVRKGNIIRVTTADRLEAEEERRRRSRQAELEDQESLRKLEPLQQRFIQINYARADELQPRIEDFLSERGRVTQDARTNTLIVRDTPSQLEEITQLIDNLDRPERQVLIEARVVYATESFRRELGVDWGFAYQSPGLDSNIISPDTFNFPSDLEGLLGVGYMGHEGQSFSVLEARLRLGESQGKSNTISAPQIMTLNNQEAKIEQGTDVAVDVIDADLRTRREYVPATLELIVTPQITPDNNLILNLEVSDNAPGEGGNIEVKKAETTLFAEDGETIVIGGIKKLSESQRETGIPPLSRLPILGWLFKHELVEENMDELLIFIRPKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQM3</accession>
    <name>D6SQM3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminodeoxyfutalosine synthase</fullName>
            <shortName evidence="6">AFL synthase</shortName>
            <shortName evidence="6">Aminofutalosine synthase</shortName>
            <ecNumber evidence="6">2.5.1.120</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mqnE</name>
        <name evidence="8" type="ORF">Dthio_PD2443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64286"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="2.5.1.120"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.120" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870363.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2443"/>
    <dbReference type="EnsemblBacteria" id="EFI35049">
        <property type="protein sequence ID" value="EFI35049"/>
        <property type="gene ID" value="Dthio_PD2443"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102573">
        <property type="term" value="F:aminodeoxyfutalosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00993">
        <property type="entry name" value="MqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022432">
        <property type="entry name" value="MqnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03700">
        <property type="entry name" value="mena_SCO4494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="50"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="355" mass="39706" checksum="718242E3715B4395" modified="2010-08-10" version="1">MSDTDNILSKVHDGGRISPEEALHLARSADVHKLGRAALAVRTRLFGDQAFFVYNQHLNYTNICSNACRFCAYSKRAGEEGAYVMSVDQIRVAVKSRMHEPIDEIHVVGGLNPDLPYDYYLEMLKSIKEIRPEVHIKAFTAVEIAYLAGQYEKTREQVLTEFVQAGLDALPGGGAEVFSPQLRRHLCPEKLSGEEWLKVHELAHSLNIPTNCTLLFGHVESWVDRLDHLQALRDLQDRSSGFLCFIPLPYQPGRNELQAAGPDGVDLVKMWAISRIFLDNIKHIKAYWAFCGIKAAQLGLWYGADDFDGTIVEEKVGHAAGADTPTGLGVDQLKHHIRAAGMKPVRRDSFFQPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQP6</accession>
    <name>D6SQP6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Extracellular solute-binding protein family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870386.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2466"/>
    <dbReference type="EnsemblBacteria" id="EFI35072">
        <property type="protein sequence ID" value="EFI35072"/>
        <property type="gene ID" value="Dthio_PD2466"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1632224at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005768">
        <property type="entry name" value="Lys_Arg_Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01096">
        <property type="entry name" value="3A0103s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088032" evidence="5">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="27"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="7">
        <location>
            <begin position="27"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="260" mass="29454" checksum="644E9AA807B42119" modified="2010-08-10" version="1">MRRFFYITALVLLGCMLLAGTSLARDKVRIGTEGAYPPFNYMDSQGNLKGFDIDIAKALCEAANLECEFVTQSWDGIIPALLARDYDAIIASMSITEERKRRVDFTEKYYQTPARFVKHKDRDIEISKDDLEGLSVGVQRATVSANFINDNFDDVLDIRSYATQEEANMDIVSGRVDLLFADAVVLQTGFLDSEEGQNYEFVGPSYTDEEWFGEGIGIALRQGDDDLRETFNQAIQDIREDGTYQEINDSYFDFDVYGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQS2</accession>
    <name>D6SQS2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmB</name>
        <name evidence="6" type="ORF">Dthio_PD2492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870412.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2492"/>
    <dbReference type="EnsemblBacteria" id="EFI35098">
        <property type="protein sequence ID" value="EFI35098"/>
        <property type="gene ID" value="Dthio_PD2492"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="68" mass="7541" checksum="4C3ED3513DD6A760" modified="2010-08-10" version="1">MTKQCEVCGKKPATGNNVSHANNHTRRRFMPNLRRVRAQLPQGRVRKIRVCTRCLRSGAVVKPAAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQW1</accession>
    <name>D6SQW1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870451.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2532"/>
    <dbReference type="EnsemblBacteria" id="EFI35137">
        <property type="protein sequence ID" value="EFI35137"/>
        <property type="gene ID" value="Dthio_PD2532"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50343SF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1451765at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088162" evidence="1">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="251" mass="29422" checksum="E997A1460F5378EB" modified="2010-08-10" version="1">MKFYCGILCLLLSTFLVFSCAPKRIPVERPPEVVWQDFWEQSSSFQEDQEFYIQTSVNYSTPDQQRRVQAAIWGFAGYPVRMDISAGFGQTVSMWLEDELRWQAYNPGENTRYIHHDGSRGATLLGFPTPMGLRETSLVLLGDFQHLVPREYHRVESHENMWKYYFEDENITSVVLEQDGSLNMIKGDGWHVEFKGIEQENDLFYFSRLDMHLSEDKEAVIRIRSVDVDRTWDQEQMSLDPPDGTRTIFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQW5</accession>
    <name>D6SQW5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870455.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2536"/>
    <dbReference type="EnsemblBacteria" id="EFI35141">
        <property type="protein sequence ID" value="EFI35141"/>
        <property type="gene ID" value="Dthio_PD2536"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034391">
        <property type="entry name" value="Cmo-like_SPASM_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030896">
        <property type="entry name" value="rSAM_AhbD_hemeb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00542">
        <property type="entry name" value="alternative_heme_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01387">
        <property type="entry name" value="BtrN-like_SPASM_domain_contain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04545">
        <property type="entry name" value="rSAM_ahbD_hemeb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="14"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="360" mass="40080" checksum="4DE84B5D74E684D3" modified="2010-08-10" version="1">MNSQNHDATSPAKAPDLRLVAWEVTRSCNLACSHCRAEAHPEPYPGELDTAQARSLIDTFPQVGNPVVIFTGGEPLLRPDIFELISYADSQGLRCVMAPNGTLITPENAKEIKSSGIQRCSISIDGPTAQEHDLLRGVPGAFEQSMAGIEYLKSAGVEFQINTTVTKDNLDKFKDIFNLARDLGAVAWHIFMLVPTGRGADLRDQFISARQYEDVLNWFYDFRKTTDMHLKATCAPHYYRIMRQRAREENVDVTRENFGLDAMSRGCLGGIGFCFISHVGQVQPCGYLELDCGNIKTTPFPEIWQSSQHFNALRDISAYKGKCGKCEFHRVCGGCRARAYTMSGDYLAQEPLCSYEPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR08</accession>
    <name>D6SR08_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870498.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35184">
        <property type="protein sequence ID" value="EFI35184"/>
        <property type="gene ID" value="Dthio_PD2584"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339ZW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2070736at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8290" checksum="3D28C1FC5C11D96D" modified="2010-08-10" version="1">MINDTEIKEKGFQILAQHLGDVEAERFIALIQRESFDYTKWRQGIDEELSIEEISRKAMDLRNKNTEKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR94</accession>
    <name>D6SR94_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate synthase (NADPH)</fullName>
            <ecNumber evidence="3">1.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870568.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0536"/>
    <dbReference type="EnsemblBacteria" id="EFI33210">
        <property type="protein sequence ID" value="EFI33210"/>
        <property type="gene ID" value="Dthio_PD0536"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="151647at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="545" mass="58933" checksum="E7F9DD818788A4D8" modified="2010-08-10" version="1">MPADAAITPSTLSQRDLPWQIHWDVHTCTLCGRCTAVCPVNAIELGTFRKRNIVVPFVGGQEKPASNFGVYHGIRQRTDPGYACIGCSMCNLVCPNNSISAIKSESTDMLRFHRDRGGQPRTRGGRRNHGDSVLDQMKFMRISMLTDPALDAGRHEFELRTLIGRVLPPAKALASWKENGWTPPVREIHPLMIGSMSFGALSPNMWEGLQMGVAYLNEELGMPVRICTGEGGCPPRLLRSRFLKYVILQIASGYFGWDEIIHALPEMKEDPCAVEIKYGQGAKPGDGGLLQWHKVNKLIAAIRGVPPGVSLPSPPTHQTKYSIEEAVAKMIQSMSMAWGFRVPVYPKISASSTSLAVLNNLTRNPYASGLAIDGEDGGTGAAYNVSMDHMGHPIASNLRDCYLNLVKLGQQNELPLIAGGGAGKNGNLAANAAALIMLGASAVQIGKYIMQAGAGCLGTEGDRCNICNIGRCPKGITSQDPRLYRRLDPEKVAERVVDVYVGFDTEIKKILAPLGRSTSLPIGMSDALGIADWAVADRLAIKYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRC3</accession>
    <name>D6SRC3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
            <shortName evidence="1">FL hydrolase</shortName>
            <ecNumber evidence="1">3.2.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Futalosine nucleosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqnB</name>
        <name evidence="3" type="ORF">Dthio_PD0565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>futalosine + H2O = dehypoxanthine futalosine + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:25904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:58863"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="EC" id="3.2.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.26" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870597.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0565"/>
    <dbReference type="EnsemblBacteria" id="EFI33239">
        <property type="protein sequence ID" value="EFI33239"/>
        <property type="gene ID" value="Dthio_PD0565"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00991">
        <property type="entry name" value="MqnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019963">
        <property type="entry name" value="FL_hydrolase_MqnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03664">
        <property type="entry name" value="fut_nucase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="236" mass="25472" checksum="2DB9663C55F781F5" modified="2010-08-10" version="1">MILFTAATLKELKHFCSSMSGFDFQGSTGHCTWRKHTRMLLLTCGVGPLNAALGLQSFLAAHPQTDMVINTGIAGSYDLDLLPIGSVCVASAEIWPEYGIRTGPGPADPELLGFPLSGQDTSPVWNRIELDPRQMSNYGDVFNETLPAGWTAAASLTVAGVSGTLEVARELAGTFNAGMENMEGFALAYVCRNKKIPFSEVRTISNLAGSRNSRDWNFRDAFSSLARLPAQMFKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRF7</accession>
    <name>D6SRF7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="4">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rlmE</name>
        <name evidence="4" type="synonym">ftsJ</name>
        <name evidence="4" type="synonym">rrmJ</name>
        <name evidence="7" type="ORF">Dthio_PD0599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870631.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0599"/>
    <dbReference type="EnsemblBacteria" id="EFI33273">
        <property type="protein sequence ID" value="EFI33273"/>
        <property type="gene ID" value="Dthio_PD0599"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1798571at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FtsJ" evidence="6">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="198" mass="22456" checksum="D692A1F8BA27FA24" modified="2010-08-10" version="1">MKKIRDHYSRQARQDNYPARSVYKLKEMDRRFSLLRPGQKVLDLGASPGSWCSFAAQKVQSRGFVLAVDLKEPTLSFPQHVVFIQGDIINDNAAREQVRDFAPFDLVLSDMAPKTTGIKITDQARSHELAREAFDLAREMLGPGGSMVVKIFEGPDVQELGREMKACFKRVKHFKPKSSRAESKEIFLVGMELVQQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRK9</accession>
    <name>D6SRK9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870683.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0652"/>
    <dbReference type="EnsemblBacteria" id="EFI33325">
        <property type="protein sequence ID" value="EFI33325"/>
        <property type="gene ID" value="Dthio_PD0652"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="516"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="931"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1142" mass="127509" checksum="6E194FFCAF9F1C87" modified="2010-08-10" version="1">MSPEIEDAAQRSQALDPKRSFIVQAPAGSGKTELLTQRTLALLCTVQAPEEVVAITFTRKAAGEMRTRILQALSRAADGETPGAPHEKTTLDLAARVLERSRSLGWELESSPGRLRIQTIDSLCSGLVSRMPLLSSLGGQGRINDNPGEMYLQAARSTLAQLHNSSPDAGHWRESIRVLLRHLDNDHDKTCRLIAGMLPQREKWLRHLADPGNSRLQRQYLEQALTRAVEEELKEVSRLMPLEELPRIARLAGFAASNLQDEDQKSTLERLAGLDSLPGCNCRDHPAWLDLARFCLTKGGTIRRTADKSLGFPAPSGTRDPELKVRLEEMKAQFKACMQTLACIPGLEMRLQEVRLLPGTTYSGSQWQTLEALFDVLRLAAACLQLEFQDQGSVDFTEITTRARQALGTDEDPTDLALVLDSRIQHLLMDEFQDTSISQYQLLLALTAGWTPGDGRTFFAVGDPMQSIYGFREAEVGLFLQARSQGLDHIPLEPLRLTVNFRSQAGIVDWANQAFPRVLPEVEDQMTGSVPYSGSHAFLPPLEDPAVQVHPFFDADFQPESSRIVSLVQQARQEDPGGTVAILVRSRPHLQAALPALRQSGLEYQAVEIDPLSRRPVIQDLCSLARALTHPGHNLAWLAVLRAPWCGLDLEDLAILAADKDAFIVNRIQDQDILSSLSPQGRRRLDRVREILLKFLQQRQRSGLRSQVESCWKALGGPDCLHSQSQRRDADVFFRLLQQRLEHSPHRVVDELENAVAGLYAGPDTSAGQDLQVMTIHKAKGLEFDTVIIPGLGRAPGSDENPLLVWMERTSPRGHTDLLMAPKTATGEDKDPVYAYIQRLMARKTSHEDGRLLYVACTRARKRLHLLGHTGLTEKGLPSKPAGGSLLESLWPAVKDEFERAAATPRDDADTREEHGASAGQTLYRLHQDWQPPRLPAGITTPSDSRPDPGQESIVFDWAGETIRLAGTCVHRWMLTMAEEGIHKWSVKKIRGLKSVFARQLMDLGMLEKSLEEGVDLVQQALENTLNHDTGRWILGPRQRARNEYALSGLDNGQAVAVSMDRTFVDDAGLRWIIDYKISRHSGKDVQRFLDQEQARYQERMQTYARLMQAAEPGPVELGLYFPLLMQWRHWPAGDYSKLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRP3</accession>
    <name>D6SRP3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33359">
        <property type="protein sequence ID" value="EFI33359"/>
        <property type="gene ID" value="Dthio_PD0687"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DMC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="19167" checksum="F98667FD0FC493D8" modified="2010-08-10" version="1">MAGQSKKRVHIKEELHHKLNLVALQENLRPSVLLESILNDYIQEKEFIDMKADDKRRFRRKSVVLPAMVYEGSDDPNVGRYFATTVYDISVGGICLAFPLEREGKIEFLKSRSEYEVICYLSGSEELSRFKCIPHYASRDDYTLKVGGSFVQAPADSHDKLSQYLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRV2</accession>
    <name>D6SRV2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33418">
        <property type="protein sequence ID" value="EFI33418"/>
        <property type="gene ID" value="Dthio_PD0751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="3">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="190" mass="22425" checksum="925C091C18ACA139" modified="2010-08-10" version="1">MLDRQIQDYLEWMNNAGYAPWTMAQHSQILNRLLDFVVLNSIPWERTFARDTLQAFKDHVQVKYAGFVLRGFMRYLHQNGIICLPPGALPEGRGRSKLQRAQLPRLYEEYLQFYTQTRQVGKQQIYRVQGTLSALNDYLQNQGMELKDLDVLHMDAFLAERNRNFAPETRINQRSVLRGFLRYLLMRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS10</accession>
    <name>D6SS10_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870828.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0810"/>
    <dbReference type="EnsemblBacteria" id="EFI33476">
        <property type="protein sequence ID" value="EFI33476"/>
        <property type="gene ID" value="Dthio_PD0810"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="104"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="277" mass="31223" checksum="0DAA29F740365E03" modified="2010-08-10" version="1">MTDPVRPSGTGPSRTVLRSSRSRLSIQALIMNLTVYPLLILQTLFFILLAPLVLPLAKFLAGRDVGRTVRYFIWVYGRIWMVIMSPFVRFETDGLSADRFPVPCIIVVNHLSFFDIFCMGALPFSNVAFTVRKWPFRMFWYAPFMRLAGYVDMESLGVDRAMRRCSALLSQGVSLMFFPEGHRSRDGELGRFYSGAFKLAVQTDTPLVPVCISGTDQLLPPGRFFMAPATVRMQALGSIEPSGFSGESDHVALRKQVKERIDQALADMRRCSQESNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS27</accession>
    <name>D6SS27_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diacylglycerol O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870845.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0827"/>
    <dbReference type="EnsemblBacteria" id="EFI33493">
        <property type="protein sequence ID" value="EFI33493"/>
        <property type="gene ID" value="Dthio_PD0827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10576" checksum="D24F1B95A1AECAED" modified="2010-08-10" version="1">MQDSNHMQQARVTGIKTAERLDLTPQWVRRIRVAGDSLKKAVQTLPRGVLTPAVITRQDMWEIKHHMLMHEKLRARPVPELCPGRIIKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS33</accession>
    <name>D6SS33_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">Dthio_PD0833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870851.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0833"/>
    <dbReference type="EnsemblBacteria" id="EFI33499">
        <property type="protein sequence ID" value="EFI33499"/>
        <property type="gene ID" value="Dthio_PD0833"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="139" mass="15571" checksum="A109310A35AC7383" modified="2010-08-10" version="1">MTQRTLSIIKPDAVQRNLQGAIMKMIQDSGLKIVAMKMLRLSKDEARGFYDVHKDRPFFDSLTDYMSSGPIVVSILEGENGIDKYREIMGATNPENAQEGTIRKAYALDIEKNSVHGSDAPETAQVEMAYFFSKMEMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS53</accession>
    <name>D6SS53_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870869.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0853"/>
    <dbReference type="EnsemblBacteria" id="EFI33519">
        <property type="protein sequence ID" value="EFI33519"/>
        <property type="gene ID" value="Dthio_PD0853"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1668121at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8804" checksum="306B230199F0ECBF" modified="2010-08-10" version="1">MNFLERIEWNPKVCNGKPVIKGTRIPLGIILEQIAEGSTWDQLLRDYPELKREDIQAALFFAKANIEHSDMRKAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS70</accession>
    <name>D6SS70_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870886.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0870"/>
    <dbReference type="EnsemblBacteria" id="EFI33536">
        <property type="protein sequence ID" value="EFI33536"/>
        <property type="gene ID" value="Dthio_PD0870"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="113"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="336" mass="37637" checksum="FBB7F7A517E20182" modified="2010-08-10" version="1">MPENNTDQLQFSNSAYVQELCGPQGRNLETIHQQTGVQIESRGGSMTLTAKDQGDLELARSSLLQLYALIESGYKVYPEDVEAALRILRQDIKADLKKIFKKEVFVVSSKKTIAPRSSTQRAYLQAIKEKDLVFGIGPAGTGKTYLAVAVAISYLMQRVVKRIILARPAVEAGEKLGFLPGDMLEKVNPYLRPLYDALHDMLEFNKVQELLESGMIEVAPLAFMRGRTLNESFIILDEAQNTTPEQMKMFLTRMGLGSKAVITGDITQVDLPGAAVSGLIQSRDVLKGEEGIKFIYFNEHDVIRHSLVARIIKAYERFDQARLEKKEEGRKSEHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSD4</accession>
    <name>D6SSD4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870950.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0935"/>
    <dbReference type="EnsemblBacteria" id="EFI33600">
        <property type="protein sequence ID" value="EFI33600"/>
        <property type="gene ID" value="Dthio_PD0935"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="130" mass="13814" checksum="5C2FD31502A9029D" modified="2010-08-10" version="1">MGKDEINAFMGAGTAYKGKLAFKGTVRVDGEFEGEIDSEGTLIVGQDAVVKGTVRVGQLVLSGALEGDVKALTKVTLYKQANINGTIHTPSLMVEEGAVIRGEINMNGSDEKGQKPEGKKRRVFENRGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSE1</accession>
    <name>D6SSE1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">Dthio_PD0942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870957.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0942"/>
    <dbReference type="EnsemblBacteria" id="EFI33607">
        <property type="protein sequence ID" value="EFI33607"/>
        <property type="gene ID" value="Dthio_PD0942"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="148"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="247" mass="27606" checksum="3D2E6D24B86421C1" modified="2010-08-10" version="1">MDMRVRLTLAYDGTGYNGWQIQKDGLTIQGELEKALSRICSASIRVHGSGRTDAGVHALGQVAHFDPPPKFLNVPWNRALNAVLPPGIRVLDFARTDRKFHARFSARAKQYSYTLWTQGAFFYPQRRNFVWNTGPLDLEAMQEATTCLTGSHDFNCFMNKGTEITDTIRTVRNILLAPGFTPQETVVWIQADGFLKQMARNIVSALVQVGRKKLSQAELKSIIQGRDRALAPATAPARGLCLEHVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSL0</accession>
    <name>D6SSL0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871025.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1012"/>
    <dbReference type="EnsemblBacteria" id="EFI33676">
        <property type="protein sequence ID" value="EFI33676"/>
        <property type="gene ID" value="Dthio_PD1012"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="148" mass="16945" checksum="D4E13AF3BA6B7B07" modified="2010-08-10" version="1">MSKHHNPWMEIQSMREEIDRIMDDARDWSMGRASDRDRFALWRPVADLYETVDQYIIELELPGVDQEKISLESKGGHLLVHGEKRIEKEATGSAYQLVERSYGPFSRKFQLPRNVDSAGIKAVFKNGVLTVSIPKKDTPSKSVSIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSL9</accession>
    <name>D6SSL9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871034.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1023"/>
    <dbReference type="EnsemblBacteria" id="EFI33685">
        <property type="protein sequence ID" value="EFI33685"/>
        <property type="gene ID" value="Dthio_PD1023"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="864595at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088188" evidence="1">
        <location>
            <begin position="33"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="820" mass="91460" checksum="C40943F7471478F7" modified="2010-08-10" version="1">MVNKKSGMQAMILGLLLLSLALSGCDSGEASAQARYDDDGYWIVPLLPEGPRIDKDEAHHIDTAPAVTAEITEVDIKNGGEVEVTFVVPDYEKDHVHIELTIAKWIEEENTWMNMLQRTRERGPQDDPMYGDGVKVIRGGNLRMQDDDALTGGEEVYGGMRFTTKLKAGPGDFGNVSGELQPIDFSDGVLWRRSGDDDPTTYGDPDDTEYHEYVREFIEEINQYGDWEEGVYRVGVTERNRGQDYYVRFNAVADFKYDGQDSAELLSRDERRHTAGEAIAEGTCFTCHSDDLRFPTNEVHGEQRQDPTVCANCHNDYTWDSRNAYAEVDGWPSMDMNVLTHKIHAGMEGYVADAYAYQQVRFPDWTFGRTSRPSDDTPYPNSPGVANCTSCHAQTGGGDYAWQRENPDPDGCATCHGEGGVVFWEAEPDDPDYDYIQSTYDCGYNCSSCHGEDKPIEHTADYYHGLSERLEELATARSYEMEVVEVENAVAGESPRVTWRVHKDGEYQDLFSGRDGTYLFQGDPADFDDDAVRIGIGWGYNNSWINDGISPREDTGAIGDPAQQVAHVDNTEPGGDETTAVTTFEQPLPEQARSGRDGFVILEMGPAEMDLNSRMANISLGSGSNTLDRDPGAKVDTESCLGCHNTIGRHGTYSDQDISSCISCHNAGSLSRDDSASQGTVDFMYIIHAIHGTGEKRATFDRRRDHTVDGHYEGGYSYVTYPNTVLDCQACHTDDTHDFTEGYLDRMGVIGDKMKDRYLEGAGVNAPMASTCYSCHQDTEDDLADWELRFHLYHSGGDMYGNHDHAFYQETREKCLECHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSN3</accession>
    <name>D6SSN3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871048.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1038"/>
    <dbReference type="EnsemblBacteria" id="EFI33699">
        <property type="protein sequence ID" value="EFI33699"/>
        <property type="gene ID" value="Dthio_PD1038"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="48"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="139"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="277" mass="31081" checksum="C95B35062A4AF9A0" modified="2010-08-10" version="1">MLQRAAVKISLKEPRKRLMHMFEFLGNFGTKDVHLIHAAPKITSQQRSDIEEQLEKTAKDATNFGFNVYTHIRRGHVPTTIIETAQEKKADFIAIYWTPKSLFRNALLGNIDSDILRLSNLPVFIYNHGLFKSSVNLEQVLYATDCKHTDAAVLPYLVDRRFTASRLFILHVGERAPDPVTEEKRRKNVLDSLNALAIECSHAYNEVQPLETLGQVSKQIVKQAATLDVDLIVAGKSDKSGTVSQMLGSTAEILPHKAGRSIFIIPDACRLPACKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSP7</accession>
    <name>D6SSP7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871062.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1052"/>
    <dbReference type="EnsemblBacteria" id="EFI33713">
        <property type="protein sequence ID" value="EFI33713"/>
        <property type="gene ID" value="Dthio_PD1052"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="315" mass="35700" checksum="A74BD7DF8EE83906" modified="2010-08-10" version="1">MELNLYALKTFKEVVDQKSFSKTAARLYLTQPAVSLQIQALENYFQAPLLIREKGRIKLTQEGGTVYEYAVKLETLQAELFQSMDRHADRLMATLRLGTCFIAGEYLFPDILKSLQNKYPDTRVALSVLKCEKIFQGLLNGIFDLGITGVDPRNKGLQSKEIGRAPLVLFKSPNQGTDSGPVSVKDLLETPVVLREEGAGIHKEFTDFLRTQRLTLKHFKHVCLSESNQAIKSMVKAGMGFSLMPEFMVRQELQDKEVIPMELEEGGLEQGFYMVYRKQEGLPEIMYNLIDYIALKINKNITPAGREPLIEEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSV4</accession>
    <name>D6SSV4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871119.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1109"/>
    <dbReference type="EnsemblBacteria" id="EFI33770">
        <property type="protein sequence ID" value="EFI33770"/>
        <property type="gene ID" value="Dthio_PD1109"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="174"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="383" mass="42801" checksum="614B0E8497D1B784" modified="2010-08-10" version="1">MHDRIEKAVREIDPQRLLSLLVDMIDIYSPSGKEKDVQVYIEDWLKKEGFEVTRQEVEEDRFNLLLTMGPKDPQVYLVGHVDTVADWDFDEEGPYEQGGIVRGLGSADMKGGCAAMVETWMALARAFEPAERPPVGLALVVGEEESGDGSEVFLENRRPPWVIIGEPTSLAACYSHYGYLEACLETTGRKSHSSLPELGHNAVESMLKILLHLGRHELFQQGSSDLVYSIREMSSSRAGFVVPDRCETWIDLHLQPGMDLKKLKSLIRQRAMEAHDFIADLNLEVGFESSYPGYDLGSDHYMAGQLRFVYDYLGIPYYENIFRSQSDGNLFYEAGSRPVILGPGSLETAHTPDEHTSLAEVTSAARIYTAICASLDYDSSSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSV8</accession>
    <name>D6SSV8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33774">
        <property type="protein sequence ID" value="EFI33774"/>
        <property type="gene ID" value="Dthio_PD1113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="11105" checksum="323FACBC6D7421C7" modified="2010-08-10" version="1">MLTYLFYISIVLIITFFVVYYLSGIYFNIKKKLRYRKDISYFEQEVQRLEEKYNSPGYFQSLDSQDQKELKDRLQRYRETLTDLKNNPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSW9</accession>
    <name>D6SSW9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871134.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1124"/>
    <dbReference type="EnsemblBacteria" id="EFI33785">
        <property type="protein sequence ID" value="EFI33785"/>
        <property type="gene ID" value="Dthio_PD1124"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="38"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="279" mass="31459" checksum="1978C3C7109A9E3B" modified="2010-08-10" version="1">MEIVFWGARGSIPVCGPEYVRYGGETTCVEVRNDQGGRIILDAGTGIRRLGAVLLKEQALKTDLFFTHTHWDHIMGLPFFQPLYQPGFSINLYGQPRLQGDIHRLVFKDLFRPPHFPVPYSRVMSQINYQEFQGGVEVQGFYLETIALSHPNLGQGFRISSSGRTFVFLTDNELGYCHRGGASFEEYVRFARDADLLVHDSEFTPEEYRQKTGWGHSTCMQAMELAAASRVKRLGLFHHNQDRNDDGVDQMVQDCAGEISGKGLALECFGVFQGQAVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSX1</accession>
    <name>D6SSX1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ORF">Dthio_PD1126</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871136.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1126"/>
    <dbReference type="EnsemblBacteria" id="EFI33787">
        <property type="protein sequence ID" value="EFI33787"/>
        <property type="gene ID" value="Dthio_PD1126"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="17"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="609"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="814"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="812"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="526"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="884" mass="101288" checksum="3D283E7CEBF1D862" modified="2010-08-10" version="1">MPESLPKGFEPRDVEKKWIDYWNDNQSFTPSDEPGGKSYSIVIPPPNVTGTLHMGHALNLTLQDILCRYHRQQGYDVLWVPGTDHAGIATQNVVEKSLAAQGTTRQDLGREEFVRQVWQWKEEYGGKILNQISRIGASVDWSRLRFTMDDGLSRAVREVFVKLYEQGLIYQGDYIINWCIRCHTALSDLEMEYSEVDGGLYHLRYPLEDGSGHLVVATTRPETMLGDTAVAVNPEDERYRHLIGKNAVLPFLNRRLPIIGDEYVDMEFGTGCLKITPAHDPNDFELGRKHGLELIQVIDDLGAMTPEAGEQFAGLDRMECRKKILQELKEKDLLESSAAHRHSVGHCYRCSAVLEPYVSRQWFVKVGPLASKARDAVSSGDTRIVPGQWAKTYFEWMDNIRDWCISRQIWWGHRIPAWTCLDCGELMVTKEDPTVCTRCESSRLEQDQDVLDTWFSSALWPFSTLGWPDDTRDLQKFYPTSVLVTAFDILFFWVARMMMMGVHFMEQVPFRDVYIHALVRDASGQKMSKSKGNVIDPLLMMDKYGTDAFRFTLTSLAAMGRDIKMSEDRVEGYRHFINKIWNAARFSLMHLQEPPRRFHASAVDGLAHQWILHRLEEVKDRVRDAVENYRFNDAAQTMYQFVWHSFCDWYLELIKPELYGEDEAAKEQARSNLSQVLSEIIILLHPMIPFATQEIWSRLPGRENQDLSRELYPEKRPQCSFPEAADNMEFLQQVVTAVRGIRSELNIAPGLKLELLMQVDGPDRDFLMKHRDLIQGLAGLGDMQTGMDLEPPRGCGAAVVKGYELFVPLKGVVDIQSELARLQKELGKLEKDLSVVGKKLENPGFLNNAPADVVEKEQAKANRIREEKEKLQALYTRLEGIQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSX7</accession>
    <name>D6SSX7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871142.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1132"/>
    <dbReference type="EnsemblBacteria" id="EFI33793">
        <property type="protein sequence ID" value="EFI33793"/>
        <property type="gene ID" value="Dthio_PD1132"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="136"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="206"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="258"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="337"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="419"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="552" mass="63157" checksum="82527ECC6D253C6C" modified="2010-08-10" version="1">MNANAKEIMVVEDDPVTMMQTSRVLQEAGYNVLKAPTGEKAMEMVYNRRPALVLLDVMLPDMGGLEICRKIKSDSRLQGTYVIMFSGVQTESDDRAQGLESGADGYLVKPVRTRELLAQIEAMLRIRYAEMRLDEDRRWYEMVLNSIRELVLCMDHELTILWANQAAADSLDMRAEELIGRKCYHLWNENDKPCRKCPVTRSLESKSPDHSIVDTPDGRIWEVRAYPVKDEHDRMLSIVEVAQDITDMQKSRQALERSEKLLKEVTANMPGAVIQYQVQEEKGLLPLFVSRGVTELLGVTPEDILQDPVRLWDNVHPDDSEQVSSSMGDSLNRNEPFHGEFRVLDRDNSYKWLRISTVPYSDVREKMWYAMISDITLLKKAQEEMAYRAMHDYLTELPNRELLLDRLERAFAMASRYGHKVGVVFFDLNSFKPVNDLYGHMAGDKLLYQVGQRLQKCVRKSDTVARYGGDEFVAVLGSISSSQDVLRVARKISSEMSRPFVLEGMEIHQDFSMGISIYPDDAADPQELLRLADQSMYRAKKDPKSCYAFCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST10</accession>
    <name>D6ST10_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="2 5">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fabD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="2 5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871175.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1165"/>
    <dbReference type="EnsemblBacteria" id="EFI33826">
        <property type="protein sequence ID" value="EFI33826"/>
        <property type="gene ID" value="Dthio_PD1165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="7">
        <location>
            <begin position="9"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="311" mass="34540" checksum="73177DDF9C0C99DB" modified="2010-08-10" version="1">MSKQLTGVLFPGQGSQEANMGRDLAESDTAAMEIWKMAEQACGHPLREIFWDQGCGEMDATRYVQPALTAVNLTLWMRLESRLDVSCSAGHSLGEFCALCAAQVLEPRSVLELTSLRGRLMDEADPHSRGGMAAILKLKKDQVEDMVSRVATDTDKEILVANYNTPTQTVVSGDKEALQRLESLVQEAKGRLFHLPVSGAFHSPMMQEAAEELSDVMRKLDWKTPAFPVFFNATADMEQDPEKIRRIMSTQMTSPVYFAQLIENMHEHGAKQFVELGPKGVLTRMIPQILGRDAGIEARNLSCLKDIEPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST31</accession>
    <name>D6ST31_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871196.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1186"/>
    <dbReference type="EnsemblBacteria" id="EFI33847">
        <property type="protein sequence ID" value="EFI33847"/>
        <property type="gene ID" value="Dthio_PD1186"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503316S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923792at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12402" checksum="E88EFABFB143F111" modified="2010-08-10" version="1">MSNDTQQGASGEKKLGILVRKDQYLDQVINLVEAAYKKGLETQLFFTGKSVMLTQDPDFAKLVGKANRISVCDVSFRANELSGEVPGVSFRDFATQARNAEMVGECDRYVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST72</accession>
    <name>D6ST72_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-translocating NADH-quinone oxidoreductase, chain M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1227"/>
    <dbReference type="EnsemblBacteria" id="EFI33888">
        <property type="protein sequence ID" value="EFI33888"/>
        <property type="gene ID" value="Dthio_PD1227"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000260">
        <property type="entry name" value="NADH4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01059">
        <property type="entry name" value="Oxidored_q5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q5_N" evidence="6">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="131"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="536" mass="59530" checksum="94247B72AD5157E8" modified="2010-08-10" version="1">MLNTGFPVLSALIFFPLIAAVVLFFLRGDSNIRLFTLVVSLIECVLVVPILLGFDTTTANFQFVEKHAWIEAWNIYYYLGIDGISVLMVLLTVLLLPICVLCSWKYIGQRVKEFHFCLLLMTTACIGIFSALDFILFYIFWEAMLIPMYLMIAVWGGPQRRYASLKFFLYTLAGSTLFLAAIVAFFINTGTFSIPELMEHRYAFQFQLWTFLAMALAFAIKVPLYPFHTWLPAAHVEAPTAGSVLLASILLKMGTYGFLRFCLPITPAASEFFAPLMIALALISIIVGSLLAIGQSDMKKLIAYSSVAHMGFVTLGIFVFAFRGVEGAIMHMVNHGIITGAMFLLVGLIYERSHSRELSENMGVSKYLPAYTGFLLLFGLAAFGFPGTNGFFSKLLVLLGVFEASYILGVLFVIGLILGLVYLLRLLLNVGWGSPSSVKGWTDMNTREWVYLVPLGLLVIYLGVAPGRALSFISPSIENLLDNFHAEKDIRVEPVPEPAPEIVSGMVLELEASSGEFVQVTHSDAVFNRFDHQDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST77</accession>
    <name>D6ST77_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871242.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1232"/>
    <dbReference type="EnsemblBacteria" id="EFI33893">
        <property type="protein sequence ID" value="EFI33893"/>
        <property type="gene ID" value="Dthio_PD1232"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="179" mass="19777" checksum="4172A49420BDA360" modified="2010-08-10" version="1">MIVKSLSETLSGMWSLLVGMKVTAVNFKSPQITVHYPRQVTNLDGYRGHIELVPSDEDPTKSKCIACSNCVRICPGACISLKASKPKKKAAEEKKAAPGTETETQPEGKKEAPPKKAKPELQSFVLDYNYCCLCGLCVESCPSGALRYSSDVYVAGFTRQEFVYDLLSRLQYQAQKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6STL9</accession>
    <name>D6STL9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">Dthio_PD1374</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871384.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1374"/>
    <dbReference type="EnsemblBacteria" id="EFI34035">
        <property type="protein sequence ID" value="EFI34035"/>
        <property type="gene ID" value="Dthio_PD1374"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI34035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="24907" checksum="195EC960B2616927" modified="2010-08-10" version="1">MKSQQELILSPSLLASDFSNLAGELSALEEAGLTWVHWDVMDGSFVPNITFGPPIIAGCRKKSRLFFDVHLMIEEPDRYLEDFVRAGADLLCVHAEACRHLERTLSEIARLGARPAVALNPHTPLEILEYVLPRLDMVLIMSVNPGFGGQKFIPFSMEKIRRLKSMIAARDCKTLIQVDGGVTPENTGELVQCGADVLVSGSAFFAHPPYRERLKTFINAARDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6STR7</accession>
    <name>D6STR7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional DNA primase/polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871432.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1423"/>
    <dbReference type="EnsemblBacteria" id="EFI34083">
        <property type="protein sequence ID" value="EFI34083"/>
        <property type="gene ID" value="Dthio_PD1423"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1173531at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025048">
        <property type="entry name" value="DUF3987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13148">
        <property type="entry name" value="DUF3987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="3">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="500" mass="54560" checksum="891B1821C5FB59EC" modified="2010-08-10" version="1">MLNLAHLPDVSGMEQDMMSAALVYAETGFPVFPCRNKKPITDHGHKDATTDEAIIRKWWTRNPDAQIGTPTGPASGVWALDEDLPDGPDTLEQLIDTYGPLPPTRTQQTGSGGKQFLFSWNGCQVRNSTSKIGPDIDVRGDGGYIILPPSGHPSGGVYQWINELSPAAAPDWLSELALNPRRPKTALQDTNAATFQGTAYGRAALEREVERVSTASEGTRNDTLNKAAFALGQLVAGNGLSENDVLTALSNAALENGLEHREVEKTIQSGIEAGKQNPRSISNDGYDRGNNLPSSRESSTGALRDGNDGNDGITEDRTTLTLPPPPLDVFYYDIRKAMENIAETKKPPIEVCVSGILALASGLVGRSRGITIKAGWSERGNLYIGLVGRSSCGKSPAINSIFKPIYEKEKRYQEQYQREMEAYELALQEWRSRKKDAPPEPKPEPPVRIDLVLDDWTIEAAADSLSANPRGVLLYRDELAGMLMDLENTQEKRVPRKPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU56</accession>
    <name>D6SU56_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871532.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0143"/>
    <dbReference type="EnsemblBacteria" id="EFI32836">
        <property type="protein sequence ID" value="EFI32836"/>
        <property type="gene ID" value="Dthio_PD0143"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="125" mass="14811" checksum="A22DACEE7F62F227" modified="2010-08-10" version="1">MAHFRFEDLEIWQLAKQLAVKFHRIADRLEQRKLFRYAEQLRAAGLSISNNIAEGCGSIHPKEFDQFLNIARRSLYEDASMVHVFFALELLENDEKEELLEECDFLSRKITNYYKSRQQAARGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUA0</accession>
    <name>D6SUA0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871573.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0194"/>
    <dbReference type="EnsemblBacteria" id="EFI32880">
        <property type="protein sequence ID" value="EFI32880"/>
        <property type="gene ID" value="Dthio_PD0194"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1478472at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI32880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="26008" checksum="D2E127E029D61D3B" modified="2010-08-10" version="1">MQKSPLPNAKPLHDAARYWGADLVAVADTSRLEGIETDPSDLLQGYPRAVSIAVHLADGIMDHITSRPTPLYARHYQNVNALLDHIAIRISGLLQSWGGKALPVPASHILSEERFTAAISHKAVAIQAGLGWQGKPTILVTPQFGPRVRLTTVLTDLVLPAGKPIKNKCAKCTYCVEACPAGAIKNASTALHYDLRSEALDLDACVGQLRSNEQEKHIPPYLCGVCVSACPWGRPKGSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUI3</accession>
    <name>D6SUI3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 19">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="6 19">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">murB</name>
        <name evidence="21" type="ORF">Dthio_PD0277</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 19">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="6 19"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0277"/>
    <dbReference type="EnsemblBacteria" id="EFI32963">
        <property type="protein sequence ID" value="EFI32963"/>
        <property type="gene ID" value="Dthio_PD0277"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 19" id="KW-0132">Cell division</keyword>
    <keyword evidence="13 19" id="KW-0133">Cell shape</keyword>
    <keyword evidence="17 19" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0274">FAD</keyword>
    <keyword evidence="10 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 19" id="KW-0521">NADP</keyword>
    <keyword evidence="15 19 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14 19" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="20">
        <location>
            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFI32963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="292" mass="32025" checksum="2598AD8B7DA233E5" modified="2010-08-10" version="1">MKTVHQPDLKKMSTLKLGGVALAALYPEDEQDLEEINRNWAGKGLRCMYLGKGSNVLFTENNKDLVLVRWQGRTMPESRVQDKDRVLVLVDAGYPLPRLLGWCASRGLSGLEGLAGIPGSVGGAMAMNAGSHGVEICSLLTRIWIWTPEDGTKKLRAGQFSFGYRWFKPEGDPENFLVTAAEISLTPSRTRDVQDSIKRFYLRKKSAQPVLAATAGCVFKNPPGLEPAGKLLEQAGFRGRQNKGVAFSSKHANFLVNLGHGSSSQALDLIAEAREKVFEMSGHELQLEIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUL3</accession>
    <name>D6SUL3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ORF">Dthio_PD0307</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871686.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0307"/>
    <dbReference type="EnsemblBacteria" id="EFI32993">
        <property type="protein sequence ID" value="EFI32993"/>
        <property type="gene ID" value="Dthio_PD0307"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI32993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="437" mass="47933" checksum="53A5FF28E24F0924" modified="2010-08-10" version="1">MKQPASTGGSGLKDLRNKVLFTFFILGVYRIGVHVPLPGIDGQALSEFFAGAEHTLFGLFDMFAGGGLKNFSIFALGIMPYISASIIMQLLTVVSPTLSRWKKDEGEAGRKKITQWTRYGTVMITLVQGMGISVGLEQMTSPDGASVVIEGGWAFRLTTVFTLTAGTIFIMWLGERITARGLGNGISLIIFAGIVAGFPGALANVYQLFTAGELTLFMGIFVLAIVVGVLLFIVFVERGQRRLPIHYAKRMMGRKMYGGQTSHLPLKLNTSGVIPAIFASSILMFPATIASFSQAGFLEAVANHLQPESLVYNLIFVALIIFFCFFYTAIIFDPKDIAENLKKQGGFIPGIRPGLRTKEYIDAVLSRLTFSGSIYLSLVCVLPVFMIREFNVPFYYGGTALLIVVVVAMDTMSQFQSHLISRHYEGLMTKTRIKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUP1</accession>
    <name>D6SUP1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="8" type="ORF">Dthio_PD0335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871714.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0335"/>
    <dbReference type="EnsemblBacteria" id="EFI33021">
        <property type="protein sequence ID" value="EFI33021"/>
        <property type="gene ID" value="Dthio_PD0335"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="6">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="130" mass="13616" checksum="F6F85817C7FD27C1" modified="2010-08-10" version="1">MSDITKEQVIDFISNMTVLELSEFIKELEDKFGVSAAAPVAAMAAAPAAGGGEAAAEEEEQTEFDVVLKDVGSNKIGVIKAVRALTNLGLKEAKAKVDELPSPIKEAVSKDDAAEAKKQLEEAGATVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUU8</accession>
    <name>D6SUU8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871771.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0392"/>
    <dbReference type="EnsemblBacteria" id="EFI33078">
        <property type="protein sequence ID" value="EFI33078"/>
        <property type="gene ID" value="Dthio_PD0392"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1682190at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="198"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="907" mass="104710" checksum="BF7F386A29291785" modified="2010-08-10" version="1">MKIFLSYGHDKNTPLVEKIKADLENRGHDVWIDTSEIKFGDDWRCSITDGILESDWMLSFLSQHSTRDPGVCLDELGIALGSKGGIVKTVLVEKEKDVKPPVSVSHVQWLDMSNWEEIKDRDPKDFEQWYKGKLDEIVRVVESESNQRFAGEIEELQQKLKPVLSDARIWGLLKDGFVGREWLFKMLEDWRINNQGQQIFWITGEPGIGKSALSAWMSHYGKVHVVAAQFVEHNKPNKKDPAKVVQSIAYQLATRLDDYRKFLVQLPVLDELDSQNAFELFENLLVNPLHYAISGNREPCIILIDALDEAVSQGQNNLVEFLSEQAQRLPDWIRLVVTSRPEPSIIRRFSHIEQVKIEADDNHNINDLRKFLRVWAENNKKNIQMKEQEDKIIAASEGNFLYLREFCRGVDHEWIDFASSDSYPQGMTGLYTQYFTRQFPKIEEFEKKYLPVIELVLASSQPLPEYYASEILGLKGRDKMEVLEPLGSLFPRHNDSIAPFHKSLKEWICDDKRAGYYYVPIEDGQYKLCKYLWKEVLRYEGESIIPEDYVIRELPVQIKNLSKNKNSLPNIIDESFKYEEKRRLIVHIGNKLVESGRWLEAEQWNDINLDLHKLMLGHDHPGTIYARRKLAAIFRKLGRYEKARETLEKVLEDSTRILGHDHPDTLTAMALLASTLGDLGKHEKAKEMQEKVLENRTRILDHDHRDTITAMGNLAGTLVDLGELEKAREIYEKVLEDSTRILSHEHPYTITARNDLAGTLGKLGEHIKAREMQEKVIEDYTRILGHEHPFTITARNNLATSLRELGEYEKAREMQERVVECFTKKLGHEHPDTITARNNLANTLGGLGKYEEAREIQEKVIEGFTKILGHEHPDTISAMNNLAGTLSNLGEHEKAREIQENLFYNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV40</accession>
    <name>D6SV40_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871878.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32796">
        <property type="protein sequence ID" value="EFI32796"/>
        <property type="gene ID" value="Dthio_PD0094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="35629" checksum="BA55D448236DC7CF" modified="2010-08-10" version="1">MPRIARFIRNDRQTVYHVISRTALPGLPIKDTDKDYLLGLIKRLSRLYFVDVLGFAVMGNHFHLVARMHPEDEISNSDIIKRWQKYYGDEAQMPTDRMAEVKKRLCSLGAYVKDIKQNFTRYYNKKHRRKGFFWGGRFKSMIVQEGSTLVNLLAYVDLNPIRAGIVKKPENYRWSSLGYHTQTGNKDGLLDIDFGLKEWNELDPKEIVRKYRQFVYETGAVDAGKGKTIEKKVVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDTRKFTPVGGVEGLYSMKRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV41</accession>
    <name>D6SV41_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871879.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0095"/>
    <dbReference type="EnsemblBacteria" id="EFI32797">
        <property type="protein sequence ID" value="EFI32797"/>
        <property type="gene ID" value="Dthio_PD0095"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZGFC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077740at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="7730" checksum="39D0AC44DB3BE24D" modified="2010-08-10" version="1">MHVFADGISKVTLSNGNLRIMLTQRGPDDTTVEAGTLIIPANQASNFMNGLANSLKELDSKLKEAREQTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJT8</accession>
    <name>D6SJT8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869266.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3595"/>
    <dbReference type="EnsemblBacteria" id="EFI36141">
        <property type="protein sequence ID" value="EFI36141"/>
        <property type="gene ID" value="Dthio_PD3595"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="AlbA_2" evidence="2">
        <location>
            <begin position="607"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="752" mass="85783" checksum="D341325D726E052A" modified="2010-08-10" version="1">MSKTVFNKVDYDLDSLVMSIAIGDIGLPDIQRPFVWKNAKVRDLFDSMYKGYPVGYFLFWHNGLAADSARTIGTDNKQKPSRLVIVDGQQRLTSLYAVIKSVPVLRENFETECIKIAFNPLEEKFEVSDAAIIRDKTFIPDISVLWNDNTDLFEVVENYLEGLNVSREITPEENKAIKKSISRLQGLLSFPFTALELLPDVNEEAVSDVFVRINSKGTPLNQADFILTLMSVFWDEGRSELERFCRESRKPSKDKASPFNHFIDPSPDQLLRVAVGVAFKRARLKYVYSILRGKDLETEKFSDELRDKQFALLKDAQSRTLNLQYWHDFMNCIRQAGFRSGKMISSQNNLIFSYILYLIGRTEYKVEEFALRRLIARWFFMSAVTGRFSSSPESAMEFDLAQLREVASAEDFVKRLNHVCDITLTNDFWNLTLPNDLATSSPRSPSLFAYYAALVLLDARALFSHSKVTDMLDPAIKAHKSAVERHHLFPKGYLKKQGITSVRDTNQIANYALVEWGDNIDISDKSPAEYAPEMSERFKQERLERMYRMHALPSGWEHMNYRDFLEKRRELMAKVIAEGYATLLTGEAEEELAKEELDLSKVVMNGESDDIEFKASLRVNLHTGSKDPRIEHAVLKTLAAFLNTNGGTLLVGVSDDGTPVGIQVDGFENDDKMSQHLVNIVKSRLGVSAMTNIHARFDDHEDNRVMVIKCAKAPTPVFVKEGDRERFFIRTGPATTELSPSQTQEYIKQRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK07</accession>
    <name>D6SK07_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869332.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3667"/>
    <dbReference type="EnsemblBacteria" id="EFI36210">
        <property type="protein sequence ID" value="EFI36210"/>
        <property type="gene ID" value="Dthio_PD3667"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="71"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="275" mass="30980" checksum="D0EB06676FF62C25" modified="2010-08-10" version="1">MLSFRILDLTIALLYLSGAITFVLGLIYTRKKVQNVSIWMTMCGFVLHTADLGLKYALGLGEVLTQSQFYVSLMAWTLLLIFFLLWWRLKLNFLSLIAAPLALVTFSWSLAISPATLPIPGILQGLWFGLHIGSLFISIALLAMAFGAGLAYLHLDSKIKTKSRMGNVTKELPSLTTFDRVNHWAVLAGFPLFTIGTFSGFIWAAFTWRTIFTWDPKEIFTIGVWLIFAWLFHKRATGGWKGRKPAKLAILIFILSLISFVGINFFTETHHSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKB3</accession>
    <name>D6SKB3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869435.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3780"/>
    <dbReference type="EnsemblBacteria" id="EFI36316">
        <property type="protein sequence ID" value="EFI36316"/>
        <property type="gene ID" value="Dthio_PD3780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="115" mass="12770" checksum="3B2C77F1A6B042C2" modified="2010-08-10" version="1">MVTFVKRKIHNLVSDKKFSEILRNSVWALGAKVLAAVLGMVTYIIIARWYGADVLGIVAVLQSFLMLATIFTVLGTNTSILRLTPEHLAKYPPTSAFKVYRKTQYLVLGVSLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKB6</accession>
    <name>D6SKB6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869438.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3784"/>
    <dbReference type="EnsemblBacteria" id="EFI36319">
        <property type="protein sequence ID" value="EFI36319"/>
        <property type="gene ID" value="Dthio_PD3784"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YDN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1948244at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10338" checksum="DE48C9465B0237B9" modified="2010-08-10" version="1">MPVLSIFFGIIIRMRHDDHPPPHIHAAYQGFEALIEIKTGTITDGYLPNKAAKIVREWCLVHQAELLENWERAQRFEPLERIQGADFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKC2</accession>
    <name>D6SKC2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">Dthio_PD3791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869444.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3791"/>
    <dbReference type="EnsemblBacteria" id="EFI36325">
        <property type="protein sequence ID" value="EFI36325"/>
        <property type="gene ID" value="Dthio_PD3791"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15117" checksum="C16AC58177B5FCB5" modified="2010-08-10" version="1">MIYLIDTNICIYLMNQKPSKVIQKFKNTKVGEIGISTITVSELNYGVAKSNLKKQNAQRLEEFLTPFEILPYDEAASKHYGMIRSELESQGKVIGPLDMLIAAHALSEDLVLITNNEKEFLRIKSLKVENWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKG7</accession>
    <name>D6SKG7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketose-bisphosphate aldolase class-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3841"/>
    <dbReference type="EnsemblBacteria" id="EFI36370">
        <property type="protein sequence ID" value="EFI36370"/>
        <property type="gene ID" value="Dthio_PD3841"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="28748" checksum="3C714E434FBF6CE8" modified="2010-08-10" version="1">MELMPPPGAVGCFSVYSSECIEAVISAAELECRPAIVSMDQNVIKDTQLDEMAREAFHMARASSVPISVHLNHAESLEGIKVGLDLGFSSVMFDGSNLDFDENIRQTCEARIMAHAYGSEIEGEYGMLCITNEDLEKINQFLRKTMVDYLAFSADKSMTMQKQKQSLLTFKQLVKESGVPLVLHGASNIDQILLKKFQVSGVRKINVHSEILKAMKDYQYEINMSCHKVSQAIYKSEIKKIIKQVVQNKIKQFLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKG8</accession>
    <name>D6SKG8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.7" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869487.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3842"/>
    <dbReference type="EnsemblBacteria" id="EFI36371">
        <property type="protein sequence ID" value="EFI36371"/>
        <property type="gene ID" value="Dthio_PD3842"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="889365at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008789">
        <property type="term" value="F:altronate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GD_AH_C" evidence="3">
        <location>
            <begin position="4"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="42165" checksum="16C335E31295F270" modified="2010-08-10" version="1">MKNKFLGFRRENGRVGVRNHVVILPLDDLSNAASEAVGNNVKGALALPHAYGRLQFGEDLDLYFRTLIGIGSNPNVAAVVVIGIEPQWTNKIVEGIAKTGKPVTGFAIEQNGDFNTICAASRKAMEYVQWASELQRTECDISEIWVSTKCGESDTTSGIATNPTVGNAYDKLYEHNSTLLFGETTEVTGGEHLIRERCINDEVRNQFQFFFDRYAKLVDEKKTSDLSDSQPTKGNIEGGLTTIEEKALGNIQKIGRKAPVVGCLDKAETPTGPGLWFMDSSSAAAEMVTLCAAAGFVVHFFPTGQGNIIGNPILPVIKLCANPRTLRTMSEHFDVDVSGLVRREMDLEQAGDSLLNMMERTANGRLTAAEVLGHREFIITKLYESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKL7</accession>
    <name>D6SKL7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868362.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35228">
        <property type="protein sequence ID" value="EFI35228"/>
        <property type="gene ID" value="Dthio_PD2637"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9454" checksum="DEA4385F01EE65D9" modified="2010-08-10" version="1">MGLLHQPSGITPDSGRSKRRIFAPRRCPSCGVLAQSHHTVCTSCKARLYCPKKVSDLKIMTLGVLLSLLCFILVVCFMFVLDRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKM0</accession>
    <name>D6SKM0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GAF sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868365.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2640"/>
    <dbReference type="EnsemblBacteria" id="EFI35231">
        <property type="protein sequence ID" value="EFI35231"/>
        <property type="gene ID" value="Dthio_PD2640"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1362191at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="186" mass="21037" checksum="7B8320003B134824" modified="2010-08-10" version="1">MESKELYKTIYKIARVVNSSLEPREVLGQIVEQVTKAMNAKGCFIRLLDRSGTVLKPDAYYGLSERYAHKGTVEVAKSKLDQEALEGRPVYIEDVRTDHRFQYPQQASEEGIVSLLVVPLTAQGDKIIGVLRVYSGQARSFTDEEMDFLSCTANLCGIALENARMYHALKRTSELANEYVYQVFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKW0</accession>
    <name>D6SKW0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868453.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2736"/>
    <dbReference type="EnsemblBacteria" id="EFI35321">
        <property type="protein sequence ID" value="EFI35321"/>
        <property type="gene ID" value="Dthio_PD2736"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="51"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="295" mass="33533" checksum="C965585130EDBDFF" modified="2010-08-10" version="1">MKFLPNTVINFHAIHDPEWMDSVLSLLKKCYHVIPIHELERFYFGSHPLKNTCHLTFDDGDATFYRNAIPLLKKHNVSASIYVSPKAIREGGNFWFQEIRGYDEHKLVAIARKRTKNLNISQDIANEAIFKSLPLDMIWDIIEEYRQETGTPPKPATNMSTEHLREVQNSGLVAIGAHTQNHPILSNENDQTAEQEILGSITELADLLSSEVRYFAYPNGRPGADFGQREMDILSKAGIKIAFSTEKKRFSHKDNPLAVPRNGLTYGNNAFVLAKLMAGSKWDLLKKMKTPLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKY4</accession>
    <name>D6SKY4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868477.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2760"/>
    <dbReference type="EnsemblBacteria" id="EFI35345">
        <property type="protein sequence ID" value="EFI35345"/>
        <property type="gene ID" value="Dthio_PD2760"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503468M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1471166at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="250" mass="28559" checksum="E0B881F690D0CC78" modified="2010-08-10" version="1">MKNMDKFAENLMDETLKEAAETFFGKRRELEDDLEFLQQQAEELQRQARGIEGIVTRLNHVLGRGSAAQEFWTGLDSSELAGVPADWEHDVALPRAWTRRGRFLGLVRSLYMQLAERIDVYTHGRYVEDKEVAGKKQLTTNLKSVTDFAESINAAIREINACNRPDDVMAFARSMDVEGGQKRKLAGSDLTYNFDQDLCFKELSIDDLGLAKYPELSTDRQSMQKVDALAKDIYSRYKKEIKDVLDEIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL54</accession>
    <name>D6SL54_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868547.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2833"/>
    <dbReference type="EnsemblBacteria" id="EFI35415">
        <property type="protein sequence ID" value="EFI35415"/>
        <property type="gene ID" value="Dthio_PD2833"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1488991at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045738">
        <property type="entry name" value="DUF6088"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19570">
        <property type="entry name" value="DUF6088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="243" mass="27156" checksum="2DB335B7BCF3AD20" modified="2010-08-10" version="1">MSIQQSIQKKIDRVAPGKIITYRNLSDLHDACPSAVAKGMERLVRKGVLVRQRPGVFYKPEHGRFGPLALQESEILRQFMFEDGRLTGYLSGPDAFRALGITTQVANTVTIATPRNRRGVELEGLSIRFIQSRVKTIQQGDIPKLQLLDAMSRIRKVPDVDIDEAVKKMIAILADYSDKDRERVFLLAKKYGPRVKALLGAILQDIGRDDLAMQLKSRLNPSTAYKIGVSADVLPNKAEWSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL73</accession>
    <name>D6SL73_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868566.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2854"/>
    <dbReference type="EnsemblBacteria" id="EFI35434">
        <property type="protein sequence ID" value="EFI35434"/>
        <property type="gene ID" value="Dthio_PD2854"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="263" mass="28721" checksum="63403F11082C4ED8" modified="2010-08-10" version="1">MNAVKISGVSFSRAGQHILQDISMEAGEGEFLAIIGPNGAGKTTLLRLAAGLEQPDSGCVQMLGRAVSSYTRREFAAQVALVPQEVPLEMPFKVAETVLLGRSPHLGLWEMEGEKDRQLALQAMQNMGVEHLAGRRLDQLSGGERQRVFIARAICQQPRVLLLDEPTASLDPAHQVGIMDLLEGLCREQGVSVIMVSHELNLAAMYADRMLLLSRGRTAGTGAPHEVLTRELLEKSYGCRIMVDENPLGKVPRMMPVPEKYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLA9</accession>
    <name>D6SLA9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868602.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35470">
        <property type="protein sequence ID" value="EFI35470"/>
        <property type="gene ID" value="Dthio_PD2890"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2193308at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="164" mass="18924" checksum="85BA5396984DCB6F" modified="2010-08-10" version="1">MKMGAPKTITEELMNKIYQMYDSGMINEITLQSIVNKAKPLACIEPVHYEYIMGAVACLRKDETSMRKCYNRVLTNHPDIPESHYNFALSLYKINKYLEALHQVNIALNLQPDYEPAQNLKKNIEDHIEKQMWDGIENDTEESLLSFCANTTMALEKNDSCEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLG0</accession>
    <name>D6SLG0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2945"/>
    <dbReference type="EnsemblBacteria" id="EFI35521">
        <property type="protein sequence ID" value="EFI35521"/>
        <property type="gene ID" value="Dthio_PD2945"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YPT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1769431at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="244" mass="27732" checksum="1F66DED15911139B" modified="2010-08-10" version="1">MSCYYRLFVILLLFMFIGGCTYYEKPYQPRAAQPVSSQVPVPTGYSLTTQKKMQAVQHWELLAGDVARRIENSLEARSIPMGSYSIYVAPPGSTPFEKAFYDLVLTKMVQQGMRVSRSESQSMVLSFDLEMVRHSERMVRTQKGVYRSLAPGMYVKRQPPGQASPGTIAPQERQVGGAMVNVESGAYTPELPSVEVMVTTSLTMNDNYIMRDSSIYYINDADWDHYKQHSIYRDPSKVNYRLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLJ7</accession>
    <name>D6SLJ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868690.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2984"/>
    <dbReference type="EnsemblBacteria" id="EFI35558">
        <property type="protein sequence ID" value="EFI35558"/>
        <property type="gene ID" value="Dthio_PD2984"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335XC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1760726at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="14675" checksum="A1EF0D022FACF1C1" modified="2010-08-10" version="1">MSGNPAELMGTKNQDLGVTLLQQAVKAWDVDAEVAVSFFEEAEPRGPLETMMVGHMAAAHSYAMKLMAEARHSMNSDVEKERLEMAQKLIRTYTSAYEKLIKSRKGGNQNVRVEHVYVGEGGQAVVGGYQNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLL9</accession>
    <name>D6SLL9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868709.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3006"/>
    <dbReference type="EnsemblBacteria" id="EFI35580">
        <property type="protein sequence ID" value="EFI35580"/>
        <property type="gene ID" value="Dthio_PD3006"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1965866at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="8858" checksum="954279A2D65F50DC" modified="2010-08-10" version="1">MPKIPSMSSTELVKLLVKSGAFFVRQGKTDHAIYARIVDGRRYSAPVQMGKKSLNPVYCKRIFRQLKLTDSEIEDVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLM1</accession>
    <name>D6SLM1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3008"/>
    <dbReference type="EnsemblBacteria" id="EFI35582">
        <property type="protein sequence ID" value="EFI35582"/>
        <property type="gene ID" value="Dthio_PD3008"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="9150" checksum="C1FD43C09F62469F" modified="2010-08-10" version="1">MMHYRAVIKRTDDWWIGWLVDLPGVNAQERTREELLESLREGAKDMLETEVPFEPGFEMEKVEVPEPEWVFKQACLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLQ3</accession>
    <name>D6SLQ3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="4">3.1.1.61</ecNumber>
            <ecNumber evidence="4">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cheB</name>
        <name evidence="10" type="ORF">Dthio_PD3043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CheB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="4"/>
    <dbReference type="EC" id="3.5.1.44" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868743.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3043"/>
    <dbReference type="EnsemblBacteria" id="EFI35614">
        <property type="protein sequence ID" value="EFI35614"/>
        <property type="gene ID" value="Dthio_PD3043"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="9">
        <location>
            <begin position="172"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4 6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="365" mass="39906" checksum="CC61DFD285704591" modified="2010-08-10" version="1">MKLKVLVVDDTIVYRKILSDVLADFPSVEVVGTASNGKIALSRIESLKPDLITLDVEMPVMDGVQTLEEIHKMKLGIGVIMVSTLTKKGSEITMKALELGAFDFVTKPDSESREENIKQIRASLAPRINHFLKRFELKKALKGDRAQKKEEKPREPREPRPAPPSRTPGRSTYEKSDIVAIGISTGGPNALTKMLPMLPGNLGVPVAIVQHMPPLFTKSLAESLNQKCALEVKEVQDGETVRKNVVYIAPGGKQTKIVAGANQARIFRVTDDPPENNCKPSVDYLFRSVAREYKSKVTGVIMTGMGNDGTLGLKVMKSFGAVTMGQDADTCVVYGMPKIAWDAGVVDMEFPLEKIAAEITSTVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLR6</accession>
    <name>D6SLR6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphohistidine phosphatase, SixA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868756.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3056"/>
    <dbReference type="EnsemblBacteria" id="EFI35627">
        <property type="protein sequence ID" value="EFI35627"/>
        <property type="gene ID" value="Dthio_PD3056"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1707924at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004449">
        <property type="entry name" value="SixA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00249">
        <property type="entry name" value="sixA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="16837" checksum="7395FFBCC391BF58" modified="2010-08-10" version="1">MQIYLVQHGKSRPKDQDPDQSLSPEGEKEVRRIAETAGDYRVPVQGILHSGKKRAEQTARIMSGTLNPAISIEAAQGLGPLDDVQAWKDKLEELNHFMLVGHLPFMQRLASLLVNGDQDNQVIKFQNGGIICLEKEQGWHIKWTLMPSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLU2</accession>
    <name>D6SLU2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868782.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3082"/>
    <dbReference type="EnsemblBacteria" id="EFI35653">
        <property type="protein sequence ID" value="EFI35653"/>
        <property type="gene ID" value="Dthio_PD3082"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1604738at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="328" mass="37463" checksum="1359860CA8558571" modified="2010-08-10" version="1">MASYTEENIMVLEPDRDRALEIAEDLNLWGLKPCIYASHFRALGRMEEKRFPLVLASMEYTGIDGLEFCRILRKRQQLGQLDFAYIILMGENQHRTRICASFDGADDFIIYPFLRCELKWRVLSGLSRYRHHEKLQTSSMYDPATLALNEKGLKKALYQEVNRMGRKKGFLSAAVLDFKNREWMEVSLGTGLCTQVKEEVFRFLKEKLRNYDQLVRTDQDRICIISGENDIDGITGMLKRISAFIAEMEVNEPGTRDFDFSLAGSFLSVSVHSTYADITACAEHVHDWIRSRDSFSDAVTGYSGTLDENGIHVDGEPVRMHPGSGAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM42</accession>
    <name>D6SM42_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoporin Nup100/Nsp100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3183"/>
    <dbReference type="EnsemblBacteria" id="EFI35753">
        <property type="protein sequence ID" value="EFI35753"/>
        <property type="gene ID" value="Dthio_PD3183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8635" checksum="47C95C1C9ABBC819" modified="2010-08-10" version="1">MRNRINVIVTTSIQAVNLVREGTGSFKILMNDKKLLCGERFDCLDSIITRSNKDMANMLLNNLVNIEAQAIRHVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM49</accession>
    <name>D6SM49_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868889.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3190"/>
    <dbReference type="EnsemblBacteria" id="EFI35760">
        <property type="protein sequence ID" value="EFI35760"/>
        <property type="gene ID" value="Dthio_PD3190"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033K5A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11629" checksum="F9ABB7821974A3CD" modified="2010-08-10" version="1">MIKPGKHDIKLNILISGKELEELQRHTHCMAEAFGLDRRIENYKGKRPLGLYSWDFDCLLDVIEDVLKDPREYPDRSDPGYIALCNLFERLKEEYQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM84</accession>
    <name>D6SM84_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NADH:ubiquinone oxidoreductase, subunit G, iron-sulfur binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD3230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868924.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3230"/>
    <dbReference type="EnsemblBacteria" id="EFI35795">
        <property type="protein sequence ID" value="EFI35795"/>
        <property type="gene ID" value="Dthio_PD3230"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="11">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="10">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="375" mass="42392" checksum="6365E6B7E84C7A54" modified="2010-08-10" version="1">MGTDMVTLNIDGKDVTVDKDSTILDAARKLDLTIPSLCHNPDLIPFGGCRLCLVEVTGTSRPVASCAALVQEGMKVKTSSNYLERLRRTNVELLLSDHPNDCMLCERAGNCKLQELAYYYGIRENRFEGENRKYPEQDQNPFIRREMEKCIMCGQCVRICDEIQGVGAIDFAYKGLWTKVCPPFEKDLDCEFCGQCVAVCPTGALTGRMWASKGRQKFREVDTVCPYCGCGCNLTLAVKKNEIARIYSRKDSINQGMLCVKGRFAYDFVNSPDRLTKPLIRTGAKKDFVLNRDNPYRESKKGHASRPDYEQFREASWEEALDLVALRLKEIKDRHGPDVIGGLASARCTNEDNYLFQKFMRMAVGTNNVDHCARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM99</accession>
    <name>D6SM99_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-sulfur cluster binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868939.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3245"/>
    <dbReference type="EnsemblBacteria" id="EFI35810">
        <property type="protein sequence ID" value="EFI35810"/>
        <property type="gene ID" value="Dthio_PD3245"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="952726at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040506">
        <property type="entry name" value="RACo_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17650">
        <property type="entry name" value="RACo_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RACo_linker" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Raco_middle" evidence="3">
        <location>
            <begin position="87"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RACo_C_ter" evidence="1">
        <location>
            <begin position="252"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="516" mass="55077" checksum="467F511B3CAED2F3" modified="2010-08-10" version="1">MKSMVQAVEVSASKPSLSDNTADLDRLKRSVRQATGQENITCPLPDMAGVAGSFRDAGFQGAAVVRDTGNGMEIISFFPGMPQKLPGMALDLGTTHLEACLVDLLSGQEMARVSREHAQGQFGADILTRIHYAERNAGLAQLQRATVSDINAMAADLAGRAGMVSGDLMALGMAGNTAMTHFLLGLSPYHMCREPYIPVANTVDIFRARDLGLEICSSAPIWVAPSVGSYFGGDLLAGIVACDLDLEDQPGMLVDVGTNAEVILGGKDWLLACAGAAGPALEGGVARMGMRAGPGAIDKVSIDPDSKFLDYSTIGGEPALGICGSGLIDLAAQMYLAGMLDTRGKFRPESMKERFVEDEHNPCFVVVQGEQSGHGQPVTVRQSDINALIRSKAAMYAVLSTLLQQVGLSFEDLGRINVAGAFGRHIDPEKAVVLGMLPDLPLNVYHPVGNTSLKGAVRAITDCDFRQRIMDAARRVTYIELNVNQEFMHRFSGARFIPHTDVSLFPSVPRPQEVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMA7</accession>
    <name>D6SMA7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868947.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3253"/>
    <dbReference type="EnsemblBacteria" id="EFI35818">
        <property type="protein sequence ID" value="EFI35818"/>
        <property type="gene ID" value="Dthio_PD3253"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1573349at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="198" mass="22686" checksum="1B5DA9073300A5ED" modified="2010-08-10" version="1">MSSIAWIVPVLLLAFFIFYMFRTYNHLIKLKNRYQNAFSQIDVQLKRRYDLIPNLVETARSYMQHERETLENVIKARNQALEASKQASSDPGEPDLMQKLSGAEGLLSGSLGRLFALAENYPDLKANQNMMQLSEELTSTENKISFARQAYNDAVMAYNTYKQSMPQAVFAPAMGFKKASFLEFDREEIKEVPKVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMD0</accession>
    <name>D6SMD0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK domain protein ATP-grasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868970.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3278"/>
    <dbReference type="EnsemblBacteria" id="EFI35841">
        <property type="protein sequence ID" value="EFI35841"/>
        <property type="gene ID" value="Dthio_PD3278"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027592">
        <property type="entry name" value="ATP-grasp_GAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04356">
        <property type="entry name" value="grasp_GAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="113"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="33030" checksum="5ED6AB8214A24DEF" modified="2010-08-10" version="1">MSIEKQKNYKIAVIGNPGSWSTEKLADELYERTSFRLVVDPAQLAFDMQGRTLVAGNTDLAELDGLAIKKIGPVYSPDMYNRLEILRFFCSLGKPVFSRPEMVMMAVNRLSCTVNLQIGNIPMPPTVITESRDEAVRAVRKFGKAVFKPLFSSKARGMLLVEDNANCGSAIANFQASGNTAMYIQKMVQIPGRDLGISFLGGKYIGTYARRKGNSWNTCTSNGGKYEPCEPDAETINLASKAQDLFNLDFTCVDVVETEDGPMVFEVSAFGGFRGLYHACGLNAAGMYAEYIINQLESRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMK3</accession>
    <name>D6SMK3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869042.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3354"/>
    <dbReference type="EnsemblBacteria" id="EFI35914">
        <property type="protein sequence ID" value="EFI35914"/>
        <property type="gene ID" value="Dthio_PD3354"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097351">
        <property type="term" value="F:toxin sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031848">
        <property type="entry name" value="PrlF_antitoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15937">
        <property type="entry name" value="PrlF_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="11410" checksum="9B33A22C9CB923CE" modified="2010-08-10" version="1">MTTIREMATMSSKGQVTLPKAIRKALNIDAGSRLAFTLRGNEIVISAEDEHNDPAVASFLNLLEQDIAHGRHVLVLPDDLVKSLVTALEYDQDHDQEISGDVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMQ3</accession>
    <name>D6SMQ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869092.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3406"/>
    <dbReference type="EnsemblBacteria" id="EFI35964">
        <property type="protein sequence ID" value="EFI35964"/>
        <property type="gene ID" value="Dthio_PD3406"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033Z6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1900042at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="16429" checksum="F75C5DA415D329DB" modified="2010-08-10" version="1">MSSFHWILLVVSAVEILLLALVFIFFFRLRRSENILTHLQDNQERFIERLNFNAQLENELVSTFEKRQKELKDLEHKLDLRIKELNKLIRQAEKFTKSPQFMKQVIITGYQNGRSVEELAKATGMSVDEVELIVEGHRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMS6</accession>
    <name>D6SMS6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3429"/>
    <dbReference type="EnsemblBacteria" id="EFI35987">
        <property type="protein sequence ID" value="EFI35987"/>
        <property type="gene ID" value="Dthio_PD3429"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="160"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="413" mass="46892" checksum="956DE6EFD3D451EE" modified="2010-08-10" version="1">MNKPKIMTGWKRILSLQQRAQEMYLTGVFIHKPENIYYFTSVYPHEPSFVLVPTEGEPELVAARSVLEEAKRDSLIPVTAGDMDIARSAYERMVDKKMLRPPPNTFLKGMMRKVSESPIGIEVDYLSLFLFKYFQIRNHMNITHEINALREIKDSFEVQRIEEACSIADQAMEHLRQKIRVGVSEKELSGIFDARAKALGAEESKCRIKSGPGTALAFSRWMDQELENGPLLIDYGVRIKGYWSDITRMFYLGSQPDSSFLEHYNLVLQARQAALEKMHPGQSIYGPEEAIRELFRRKDLEQHMIYAAGHGIGLEVHEEPLLGSAPDATREEEEDKEASLLAQSGLGSSFMSLTREMEHHIEPAFARGHVVALEPGLYFQELGVRVEDVVHISDKPRVLSSLSTDPRDMVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN48</accession>
    <name>D6SN48_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP-like extracellular</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1522"/>
    <dbReference type="EnsemblBacteria" id="EFI34174">
        <property type="protein sequence ID" value="EFI34174"/>
        <property type="gene ID" value="Dthio_PD1522"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1625525at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="296"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="539"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="779" mass="86609" checksum="FC67E5B1389CD3CD" modified="2010-08-10" version="1">MSIQFNQDLEITLGTPFTDLFANTDEEQTSWYRLWTGKLDNEGEVVRGAMVGDGWVSKDGLDDLTVGVDQAGHNTLYVQTYTDELNSWEHSTEMSFPEEITFELAIEKDVVSEDTLLSDMFSFDTPVSSSEVWFQVKVEGEPIDTTVGNGWVRGDRLGGEYFPAKHAGKELEVTPFYAGELHTDKAQTQMVDRAEHYELSIDKAYVEEDTPLSEMFSYNLPTGVTADTIWFQVKVDEEPVDTAVGNGWVRGDRLGDEYFTAERGGKELGVTPFFDGALQEGLSQEWTVQGESAAELKINFMNITPEEPEPGQEFSVDVNIEELADVETENLTVDLTIAGTEIEETIDVDSLQGTETTVTFEDLVIEDAGEYTIDVTADADNADIVSSQSTLNVSIEDFVVGIEITTQPDLEYIEGQELDLSDLEVTKSYQVAEDQVVSFSDFADYGLVVDLAQGTELTLGNDDQTIKVEHTPTEKTAETQPLSVSTQEVESHFPTDYEQYMITLINRARLDPEAEADLFGIDLNQDISPEDEISPDMKQPLAFNPDLTQAAREHSQWMLDNDTFDHTGEGGSSVEDRIKDTDYNTDPPWGWGENLALTGYTEGMDELIAQKHENLFLSSGHRENTMSESFMEVGVGSLLGDYANNTVYMSTVKFAHTSDTPFLTGTVFQDLDDSGAYKPGEGLGDVQIQVGGQGTTTWDSGGYAMQLEPGDYLLTFNHDKFEEKVEMDFTMPDENVLVDLVLEPDDLQNRTESSEPSIQEIQFMGVEKEDDTFGVSEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN83</accession>
    <name>D6SN83_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polymorphic outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869537.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1560"/>
    <dbReference type="EnsemblBacteria" id="EFI34209">
        <property type="protein sequence ID" value="EFI34209"/>
        <property type="gene ID" value="Dthio_PD1560"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003368">
        <property type="entry name" value="POMP_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01376">
        <property type="entry name" value="POMP_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="393" mass="42475" checksum="D1EA6353699DB028" modified="2010-08-10" version="1">MVIEVADDIDDFDGSQLLYEEDADLVIRGQNAESYTLNAGGDSRILETNIHNGNGSLIVENLDFKGGDGGNAGGGALLVKNNLEISGSEFSNNQSGTFGGAIYAMNPDGEATITDSSFDSNHSGIGGGISSGGYLKVESSTFEGNSADNFGGGLETQQGAQIDESSFSDNYALNGAAVYGIYNGKIQISDCSIVNNDSPYHYGVVSSSEVDIYTRDSDYIDNSDPVFDLHEAEFIDEGGNTFQGNESFNPYLNELEFYETTGSNNVRDHVYDADDLGMTFSYQEKLPREGDLDLDAFAIQITDADGNMEKIGIDSADVDGANLTLNFADELSLEWDGEQYTMSSEDWELTAESLDDFEVAVDYEDGNISDHEDFNKKVDLQGIAHDFEELCMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNA4</accession>
    <name>D6SNA4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1581"/>
    <dbReference type="EnsemblBacteria" id="EFI34230">
        <property type="protein sequence ID" value="EFI34230"/>
        <property type="gene ID" value="Dthio_PD1581"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13477">
        <property type="entry name" value="Glyco_trans_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="219"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="408" mass="46184" checksum="4FC255EA1E614877" modified="2010-08-10" version="1">MKWLQSNLIVISANTSWYIFNFRLRMIRELINQGFEVAVVAPEDEYLSRLVQEGCRILPINLLSKSINPLVEIKAIYQYVRIYSLLRPAAVLHFTPKPNIYGSLVAKMLGIPYINNIGGLGTAFAGNGWLCSMARVMYRFSQRSAVKIFFQNKDDLDMFIRCGMARPEQAELLPGSGVDLEKFNPELGDSGVHGKLTCRQSNDNSNQPLHEGQEYLFQAPEDNVVFLLIARLIWDKGIGEYAEAARAIKAKYPDVEFMLLGFVDDNNPGAVPEKRIREWEAEGILKWVGRQEDVRLFIARTDCVVLPSYYREGTPRSLLEAASMGKPLIAADSVGTREPVENGINGFLCRPMDAMDLAAKMQLIIDMGPEKRLAMGIRGRKKMEKEYDENIVIKKYIEDIKAVLVNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNC9</accession>
    <name>D6SNC9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869583.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34255">
        <property type="protein sequence ID" value="EFI34255"/>
        <property type="gene ID" value="Dthio_PD1606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="13946" checksum="5302B08B499A45D4" modified="2010-08-10" version="1">MSYDLEQELCLHNVAGCPLRLPGGEVLGYIEGVKRHKGGCEVWEVRTEENRVIMFPIYEDIVVECSPDEYVTVDPPRDLLDMYKEGKHPENPCQAVCRFDKKGRQEAREKSHVQEGAKRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SND2</accession>
    <name>D6SND2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869586.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1609"/>
    <dbReference type="EnsemblBacteria" id="EFI34258">
        <property type="protein sequence ID" value="EFI34258"/>
        <property type="gene ID" value="Dthio_PD1609"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZDE3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1989844at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="16539" checksum="788D780DBF8736B1" modified="2010-08-10" version="1">MTEDRPKVPLYNTTYGDTVYWITFAVCIACLVGPALAVLFPGNTAMDPYFTYALIFEGKTGTEIWTALYGEWPYMHSVWFKNFFTGDGFTMFAMAIGCTVAVWALIPTIVAFVKEGLTGYALFSVFIIAMILFAASGAVQIEVPVPEPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SND9</accession>
    <name>D6SND9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869593.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1616"/>
    <dbReference type="EnsemblBacteria" id="EFI34265">
        <property type="protein sequence ID" value="EFI34265"/>
        <property type="gene ID" value="Dthio_PD1616"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="149" mass="16571" checksum="7DA2DF8B45B175D2" modified="2010-08-10" version="1">MPEIKRILLPVVFSDNDNLAAGYARQIAMCAGSEVDLVHVTPHIDFISEDILQSVYTSHVGYEKEVAEKLMDTFIEKALPGVKVRKKTVLKGQPADEILNYARENSVNMIVLPTHTRKGPEAWFVGSVAERVTKKAHCPVLLVHPDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNR5</accession>
    <name>D6SNR5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1744"/>
    <dbReference type="EnsemblBacteria" id="EFI34391">
        <property type="protein sequence ID" value="EFI34391"/>
        <property type="gene ID" value="Dthio_PD1744"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031GIF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="544" mass="61306" checksum="6D5C3B2D69D7CF22" modified="2010-08-10" version="1">MGAITWEDFLSKFEDLCFVVSDEPDMDALIEDKKTNDLLKTNAEAEELDLLTEVLQKHPDVHFYRKMVGATKKDLRGLLDDCDIEGSEKALNSILSLLKLRVDKTDPEILKQDEIIKLLWEHPEIQNSCKIKGCGKKDFLKQYENNTLTPRTALEDAKKAIASTTGATNFDLKAHVNKFAVHFQSKLVHSQAKNGGVLLGKKASRSTPYLCAASLMHNGHRPDLDQTSNDSSGIYQALLKKYADYKSGQTESGNVDPAVQGFVDVVEQDDVAFIEKNMDSLDPQLKQVIVPHPDNDQYIAFVPLVSPGINKIVLDAYEENRKQGEQRFNAGRLYNLLGYGGSNAQNVCLKKNIRYINSPMLANTPQADRQDKRAWRFLLGGSDSFHFRVRWGDVENYGKWLSANRKEGMHQGEGDAGASRKLAKETGVLAQKAEASVLRPIVEECVYDMRVLSENINSLITEEGPRRILEEKEMTQDGQWEKKFLDSRNDLELFVITGMKGNETEELLVDSMMNTIDKHEDISFNVTDKSRTSQVIRGLIKEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP06</accession>
    <name>D6SP06_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Membrane-bound lytic murein transglycosylase F</fullName>
            <ecNumber evidence="7">4.2.2.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Murein lyase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltF</name>
        <name evidence="10" type="ORF">Dthio_PD1841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell outer membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">Attached to the inner leaflet of the outer membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869804.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1841"/>
    <dbReference type="EnsemblBacteria" id="EFI34482">
        <property type="protein sequence ID" value="EFI34482"/>
        <property type="gene ID" value="Dthio_PD1841"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02016">
        <property type="entry name" value="MltF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023703">
        <property type="entry name" value="MltF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009009749" description="Membrane-bound lytic murein transglycosylase F" evidence="7">
        <location>
            <begin position="27"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="8">
        <location>
            <begin position="55"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="9">
        <location>
            <begin position="292"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="LT domain" evidence="7">
        <location>
            <begin position="268"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="455" mass="52167" checksum="472615210DB71F74" modified="2010-08-10" version="1" precursor="true">MQQFLFDTFFRGIACLCLILALAACTDDPPEYVLDQPPQETGVLTVVTRSGSTTYYLDRHEVKKGPEYDLAMEFARSRGWEVNWKVVPTTAQVLEVLEAGGAHLAAAGLTHLDTRNERFERGPAHSEITQQVVCHRQMNPMPGSPEDLKNVDLKVTADSSYAERLDELSEEYQGVDYTPVEMSTEVLLGHVSQQKIECTVADSNIVQVNRRFMPHLYIAFDITEGQNLGWYLPEGCEELAREAFSWMNSREGDEAISEMYSRYYGHITQFDFVDLRALNRRIKERLPKYKEYFLQAEEKTGMPADLLAALAYQESHWDPEAVSRTGVRGIMMLTQRTARHLGVEDRLDPAQSIEGGARYLEERYRLLPEDIPDPDRLYLALASYNVGRGHLLDARQLARNLGKDPDSWDDMREVLPLLSDERYYPSLRYGYARGFEPVHFVSRIRNYRDIIARAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP33</accession>
    <name>D6SP33_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869831.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1868"/>
    <dbReference type="EnsemblBacteria" id="EFI34509">
        <property type="protein sequence ID" value="EFI34509"/>
        <property type="gene ID" value="Dthio_PD1868"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="388" mass="41820" checksum="BFAAC6659202A952" modified="2010-08-10" version="1">MSLEKPFDLYCPTKIKFGAGITAEAGVEVKALNCSKVLVVADPGVAKAGLLEGVLESLKKENLPYVVFDQVEVNATLSSVMKASELQKSEQCDIMLLVGGGSTMDTGKGVGCLATNEGPLPAYEGPEKYCNPPLPSIAVPTTAGTGSELSFGAVLYDEERNYKFSFRSCMQIPKVALLDPHLLQSLPSNVAAASGMDALSHCAEAFVSKWSTHITDAYCRQNFYLVGKYLRRFVADPSNTEAAGAMLQASAMGSMSFNTARLGLVHAMASPLGAHFHLPHGTACAVLMPAVMRFNLLACPEKYREMALLLEGAAPGSRMMEQAESAVFAIERLLDDLSMNFTVDRSAVNEEKLAQMADETLSSGMQLTNPRNVTKTDVINVYRDYFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP77</accession>
    <name>D6SP77_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HcyBio domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869873.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1925"/>
    <dbReference type="EnsemblBacteria" id="EFI34553">
        <property type="protein sequence ID" value="EFI34553"/>
        <property type="gene ID" value="Dthio_PD1925"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1900">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="390505at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002708">
        <property type="entry name" value="HcyBio"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01837">
        <property type="entry name" value="HcyBio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HcyBio" evidence="1">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="390" mass="42777" checksum="C1F7F566A853095E" modified="2010-08-10" version="1">MAFNKQVNRTIDEINQKIKSGKAVVVNARQMASLVRDKGKVEAAREVDVVTTGTFSPMCSSGMIFNFAQKPPMIKGHKIWLDNVPCYGGLAAADSFIGVTETTENDPLNKVYPGTFTYGGGHVIENLVRGNSVHLRVQGYGTDCYPRKLLEKDITLGELKSAVLFNPRNAYQNYNCAVNLTNRIKYTYMGPLRANMGNLNFATAGSLSPLFNDPYFLTTGLGTRIFLGGGTGYVIGEGTQHNPDPPRNERGIPKMPAGTLMVKGDLKQMNHRYIRGISFAGYGCSMAVGLGIPIPVLNEDIAWYAGVDDSEIHMPVIDYGYEYGAGKAKILAYVTYEQLLSGSVEINDKKVTTVPLTSYSMSLEIADQLKDWIQSGEFFLTQAQDKIESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP86</accession>
    <name>D6SP86_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1934"/>
    <dbReference type="EnsemblBacteria" id="EFI34562">
        <property type="protein sequence ID" value="EFI34562"/>
        <property type="gene ID" value="Dthio_PD1934"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088005" description="NfeD domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="4">
        <location>
            <begin position="348"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="431" mass="47133" checksum="6CEA13D8A942E998" modified="2010-08-10" version="1">MKIFKICFLASIILLAFSLVFADRDPASHQILKVDIDGPITPATEELLQDSLRRAHDEDFIALMIRLDTPGGLVESMRNMVKDILASDLPVIVWVDPPGARATSAGVFLVAASDHAVMSPQTTIGSASPVTMGGEEQDETMQSKIINEMLSLVRTVAKDKGRNVEWYEKAVTEAANIDSEEALQLRVIDHIATSTDDLLSQLGKKGLSVYGEEITFESDEISIVQFEPGFKYKILSWLLHPQIAYLLFLAGMAGLFFELSNPGAIFPGVLGSMCLIMGLYSLAVLPTNIAGILLLILGFIFIILEINMPTFGLLTMAALASFFFGSLFLFDAEHPYFQIPTMTIIPVILILTVVLLALAYLIGKSQMAPKTHQTGIPDQSAKVVSWSGTQGQVKVRGEIWRAQSQEMLSLQPGQEVQVDKVEGLTLHIKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPA0</accession>
    <name>D6SPA0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein MerR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869896.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1948"/>
    <dbReference type="EnsemblBacteria" id="EFI34576">
        <property type="protein sequence ID" value="EFI34576"/>
        <property type="gene ID" value="Dthio_PD1948"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1955320at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="233" mass="27279" checksum="70175557B125211E" modified="2010-08-10" version="1">MNQELLTIKEIARRLDLPESNIRYYRDRFDRFLPSVGHGRKKRYKPEAVEVFRCIVEELGQSRSTQEIEEVLAARFSQNPSQVTWQQDSLSPAAYAQSGSDATYLQEALVTQSRALDKLSRAMQLERGLFADLQQMQSRQDRLKRAVYLLWKGYQKSLSRDRDGHQPGEVEKLREEVESLETRQTELEEKLESELKSMREELQKCQFWTKRLLMQSAREKTEPDKGDESQTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPD9</accession>
    <name>D6SPD9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Catalase</fullName>
            <ecNumber evidence="4">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD1987</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869935.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1987"/>
    <dbReference type="EnsemblBacteria" id="EFI34615">
        <property type="protein sequence ID" value="EFI34615"/>
        <property type="gene ID" value="Dthio_PD1987"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="14">
        <location>
            <begin position="10"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI34615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="484" mass="54857" checksum="73553C4BEFD085C2" modified="2010-08-10" version="1">MADNQGKPTTNDAGMPVSSDEFSLTVGPDGPILLQDHYLLEQMANFNREMIPDRQPHAKGSGAFGHFEVTSDVSAYTKASLFQPGAKTEVLARFSTVAGESGSPDTWRDVRGFAVKFYTPEGNYDMVGNNTPVFFIRDPMKFQHFIHSQKRRADTGLRCHDMQWDFWTLSPESAHQVTILMSDRGVPRTYRHMNGYTSHTYMWVNAKGEKFWVKYHFKTDQGIEFLTDEEADRIAGQDADYHRRDLAEAIKRGENPSWTLKVQIMPFEDAKTYRYNPFDLTKVWPHSDYPLHEVGRLTLNRNPADFHAEIEQAAFEPNSFVPGIGPSPDRMLQARLFSYADAHRARLGVNYKQIPVNRPKAPVHSYSKGGAMRIENVSDPVYAPNSKGGPSADPKRYPEEAVWEASGEFMRTAYTLRKDDDDFGQPGTLVREVMDEAQRERLVSNVVGHLKKGVSGPILERALEYWRNIDKDIGERIAKGVKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPG1</accession>
    <name>D6SPG1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="9" type="ORF">Dthio_PD2009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2009"/>
    <dbReference type="EnsemblBacteria" id="EFI34637">
        <property type="protein sequence ID" value="EFI34637"/>
        <property type="gene ID" value="Dthio_PD2009"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="164" mass="18153" checksum="74D13FFD8727E644" modified="2010-08-10" version="1">MPDRYKLVIILSAAILVLDQMTKIWVESSLALGETRTVIPGFFNLVFVLNPGAAFGFLADLEGSLRTYFFLGATGLAVVLIIHLLRTVQRQDYYLFTALGLILGGALGNMIDRIRLGMVIDFLDFHLGSHHWPAFNVADIAISVGAVLLIVSFYKKKRHEADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPK4</accession>
    <name>D6SPK4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870000.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2052"/>
    <dbReference type="EnsemblBacteria" id="EFI34680">
        <property type="protein sequence ID" value="EFI34680"/>
        <property type="gene ID" value="Dthio_PD2052"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7QH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333911at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="574" mass="68831" checksum="435A52E6DB6396F6" modified="2010-08-10" version="1">MQKWYDYFLEADAYDWSDQKIPVPRFRLNSLLSLKKYLDLIHIRQCLIRPFLKTDNYPLVEARELLPSFESDLYEYEDLPGFSLVALARPLEYFNEIFQFDILHSRWAKIITTHGEACPVPDTISHTNVSTFQSRLPKNIQERFKDELGGTDIAELYNYPRVLNFILNMDRGHVMSMDTRNEFYLSGVYASFPSYLDPELKRFGLQIKKFKPNDNLRYELNRNFVYQFLMELYGYPVVSERRTSAALFSRRLFKMGERFLIRALGQTDRTITTLYNTGDCKFYPALEKVALARVETKKKDVLKFLKENGYFLDEEKKAVILRVRYKQHQYDPDNIREERALSVLRQEVIHPRTGEVCSQLNIIKDTFFMTLKLNDIVKGEFSGRIKYKREIIENTDTHEKRLKFLYAWLSKHQRRIIGYSDEFYAGVTKVLDNYLLNPELFEDFQALNDLYQEVWQKYSYIRQARKIRILQDILERRYEDKKINYLQMLEHSNSVLEELKFETGNYFPDIITRAIATVEKIANDRYLLRNYVNREENSLTQYGQEVRERYFRMNFLLNELKTIRRVKREPISYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPQ6</accession>
    <name>D6SPQ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_IS1595 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2105"/>
    <dbReference type="EnsemblBacteria" id="EFI34732">
        <property type="protein sequence ID" value="EFI34732"/>
        <property type="gene ID" value="Dthio_PD2105"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="128"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="307" mass="35343" checksum="DC50CED9F5F88590" modified="2010-08-10" version="1">MEDYPTTILELEDRFSFEKDCREYLFKLRWPEGFRCSRCSHEQYWQRTNGLFECKGCGFQVSVTAGTIFQDTKKPLRLWFRAVWHVTSQKYGANALGLQRVLGLGSYRTAWSWLHKLRRAMVRPGRDKLSGIVQVDESMFGGKRPGKRGRGASGKALVCIVAQVDGQRIGRIRLQVIPDASAESLEAAIMNTIEPGTVVQTDGWRGYNQLQKKGYAHEIVRSDYVIGDDLLPFCHRVASLLKRWLTGTHQGSVSHKHLGYYLDEFTFRFNRRTSRSRGKLFYRLIQQALMIDPVTNKSLVKKQEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPU8</accession>
    <name>D6SPU8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein, APE2256 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870090.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2150"/>
    <dbReference type="EnsemblBacteria" id="EFI34774">
        <property type="protein sequence ID" value="EFI34774"/>
        <property type="gene ID" value="Dthio_PD2150"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1067883at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013442">
        <property type="entry name" value="SSO1393-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09651">
        <property type="entry name" value="Cas_APE2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02619">
        <property type="entry name" value="TIGR02619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_APE2256" evidence="1">
        <location>
            <begin position="95"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="416" mass="47076" checksum="73ECFE6B708569B2" modified="2010-08-10" version="1">MYEQSGGPNLICTVGTSLLYSSLKPLDPETAFQLSREQVQPQHAADYDIMDKAGWLQKPQDLKDRLFQIKEALGRQEFTRLGKLLASFPAELRMLGAEINSIEAMVRKGFLGDNRVRLVLLVSDTPDGEAMGSVLQSYFTHPDCHVAFEQCYVEKVQGLQDEKPLDFQTEGLTNLVRLLGEHFRKWGGAIAINATGGYKAQIALAVAFGQAAGATVYYKHERFDQVIKFPRIPLSLDMSLVQNNLKVWADLAEPGCVLDEKDLKDLLGDDANLLQSMASLLDRVQDDGATLFSLSALGMVYWEAFRSAHPEVCLEPAKVDKRRGCRFRDDHYPVGFKEYVHKFYDSFPEHVSECHSVPYDRQSAIKNRFYDLKSGIIGEYSDRNGFGARFQVLTLAANELERSWLVKRFQEWLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPW0</accession>
    <name>D6SPW0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870102.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2163"/>
    <dbReference type="EnsemblBacteria" id="EFI34786">
        <property type="protein sequence ID" value="EFI34786"/>
        <property type="gene ID" value="Dthio_PD2163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="10939" checksum="396C714069D29C86" modified="2010-08-10" version="1">MEEKICMCSVLTNGVTIIYIINDDESWIEPCIIKAHGKPDPTRISFQPLQIFSITPVMPAINQMHILTSYSPEPEIESSYRSFLCMYLKDVAMPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPY3</accession>
    <name>D6SPY3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870125.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2192"/>
    <dbReference type="EnsemblBacteria" id="EFI34809">
        <property type="protein sequence ID" value="EFI34809"/>
        <property type="gene ID" value="Dthio_PD2192"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033J6K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029809at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="117" mass="13486" checksum="99F48652CB51987F" modified="2010-08-10" version="1">MQPTESWIKDWSYGLSPAEEREISGELVRIFQKFWCWAELDQKSKSTQQRYSASLHAMGGWAVQEVAEKKARMDAHRLLVEATSGGGGPLIYLDREEWQKELDTVCRKLSKFLCSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ67</accession>
    <name>D6SQ67_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2284"/>
    <dbReference type="EnsemblBacteria" id="EFI34893">
        <property type="protein sequence ID" value="EFI34893"/>
        <property type="gene ID" value="Dthio_PD2284"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016899">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="426" mass="47597" checksum="16883BE4D8C7A642" modified="2010-08-10" version="1">MRSFRSQEEARDILGQTDRCIPRGLGRSYGDCSLGENIISTPGFRRFIHLDPAKGILECEAGTSLDQILSVIIPHGWFLPVTPGTSRVTLGGAIASDVHGKNHHLHGALGRHVLDLRLLTPQGHVLVCSKNENPAIFQAVCGGMGLLGLILSARISLMPLESVFIRQKTIPAYDLDELMSFFDSHHQSTYTVAWMDCLQRGRHLGRGLFMHGEHCRSHEAPQSQLIPPGCKGISIPFTLPFRALTPAGIKAFNSLYFHRKSRRTGYEISSIESFFYPLDALANWNLLYGKKGFLQYQFVLPRSTSRSGLQKILQHINSFGQPPYLAVLKLLGKGQGPLSFAQPGYTLALDFPIRPGVFSLLNALDRVVQKLGGRIYLAKDARMKKHMLWEGYPRAKEFVELKKRLDPENKLSSLQSRRLGLCQNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQH4</accession>
    <name>D6SQH4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="7" type="ORF">Dthio_PD2392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870314.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2392"/>
    <dbReference type="EnsemblBacteria" id="EFI35000">
        <property type="protein sequence ID" value="EFI35000"/>
        <property type="gene ID" value="Dthio_PD2392"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="264" mass="29973" checksum="7123447879E1C406" modified="2010-08-10" version="1">MSYVTMKQMLETGVHFGHQTKRWNPKMKPYIFGSRKGIHIIDLQQTVKLYQYAHDFISDTVAGGKKVLFVGTKRQAREVINTEAQRADMFYVTNRWLGGTLTNFQTIRKSIERLKTLERMFEDGSVHRFVKKEVAMMQREVNKLNADLGGIKDMDSLPGAAFIIDPKKEEIAIKECRKLNIPIAAVVDTNCDPDLIDFVIPGNDDAIRAIKLFAGSMADACLEGMAKRGDREQQEDKAAEAQEAEAKEMQTEPEPAMQEEQQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQR2</accession>
    <name>D6SQR2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD2482</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2482"/>
    <dbReference type="EnsemblBacteria" id="EFI35088">
        <property type="protein sequence ID" value="EFI35088"/>
        <property type="gene ID" value="Dthio_PD2482"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="301"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI35088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="371" mass="40515" checksum="F8FEEDBDD0517666" modified="2010-08-10" version="1">MNQSEFMLKALGLARQAKGFTAPNPCVGALVTCGDRIMGKGWHRAPGENHAEVEAIENARENGADLSSCRMYVTLEPCNHHGRTPPCTAAVIQAGIPEIIIGARDPNSQVQGGGAEFLRNHGLRVTVGVEEQKCLDLIADFSLWQNSGRPYVYLKTASTLDGRIATRTGHSRWVTSANARQMVHQLRSIVGAVLVGGNTFYQDNPALTCRIQEVKNQPWAVVLTSRLPDPDQDFYLLQKRASRTIFWTDKNSAASPRAAGLEARGCRVMGLDAEGPGLDLKLGLEMLRRETGIYYLLCEGGGQLASSLLQQGLADEVWAFVALKILGDSLAVPVTSGREVELMDQTLDFRPGEILNLGPEILLRLFPLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQU2</accession>
    <name>D6SQU2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heavy metal transport/detoxification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870432.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2512"/>
    <dbReference type="EnsemblBacteria" id="EFI35118">
        <property type="protein sequence ID" value="EFI35118"/>
        <property type="gene ID" value="Dthio_PD2512"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="6861" checksum="1A19CE1E3BCDE3EB" modified="2010-08-10" version="1">MARIKIEGMSCGHCVKAVTDALNKMPGVSGVQVSLESGHADIDAGEDLDMAAVKKAVEDAGYKVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQX6</accession>
    <name>D6SQX6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, Csd1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870466.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2548"/>
    <dbReference type="EnsemblBacteria" id="EFI35152">
        <property type="protein sequence ID" value="EFI35152"/>
        <property type="gene ID" value="Dthio_PD2548"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7WH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="924061at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010144">
        <property type="entry name" value="CRISPR-assoc_prot_Csd1-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09709">
        <property type="entry name" value="Cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01863">
        <property type="entry name" value="cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="579" mass="65415" checksum="EEBB0D9E80AF09F3" modified="2010-08-10" version="1">MILQALNDYYERLRADPETEVSDFGFSQEKLAFSLVLSEQGSVVQLRDLRQFEGKRSFPKPAVVPKLPKERSGTNAPSYFMWDKSKYVLGCELDSDGNEIFFKNQFDSFAEVHREILGDNKDSGAKALLNFIDQRIFGQVPEWATKELLSTGFICFELDGQRGFLHERSAIRNAWQEYLRKNQSEIRGQCLITGQHDCSIPSTHPQMKNVPGAQPAGAALVSFNAPAFGSYGKGTSNHNAPVSERAAFGYTTALNVLLAPGSRRKVQLGETTVVFWTDIPGVAEEFFGLSVGVKEAEDHEMAQEVDQYLRAVVKGYYPHELGKRDTPFYVLGLSPNAARLSVRFWHVGTVGKMAENIGNHYKALRLQRSFENEPEYPRPWWLLKELAPQRDSRHIPPLLGGQFIRAIVHNQPYPRTLLTTVMGRIRADRQVNYLRACIIKAYLTRNAQKEISMGVDKENTNIGYRLGRLFAVVDYIQNDAAPGANVTVRDRFFGAAAATPRRIFPVILKNAQHSLAKIRKEKPGWAITLDKSVQTILGDVDPRKGFPATMTLEQQGMFVLGYYHQRQDLYTKQEDKTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQY0</accession>
    <name>D6SQY0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ORF">Dthio_PD2552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870470.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2552"/>
    <dbReference type="EnsemblBacteria" id="EFI35156">
        <property type="protein sequence ID" value="EFI35156"/>
        <property type="gene ID" value="Dthio_PD2552"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09721">
        <property type="entry name" value="Cas1_I-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019856">
        <property type="entry name" value="CRISPR-assoc_Cas1_DVULG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03640">
        <property type="entry name" value="cas1_DVULG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="343" mass="38131" checksum="2DCF0DA33BCB875A" modified="2010-08-10" version="1">MKKLLNTLYVTSQGSYLFKDGECVVIRLEDGSKKRFPVHVLDGVVCFGNVICSPFLLGHCAEKGLAVSFLTERGRYLASVHGPQGGNVLLRREQYRKADDEESSATTARSIVAGKVANSRAVLRRCLRDYAERVDAQRLQGAIGVLDGCAHRLKTPVSLDEARGLEGLAANTYFGVFGELILKKGPGFSFTGRTRRPPLDNVNCLLSFVYTLLAHDIRSAIEAVGLDPQAGFLHRDRPGRPGLALDIMEEFRSFLADRLVLSLINRGEVGEKGFTVKESGAVFMDEDTRKAVLVAWQKRKADEVVHPFLKERISMGLAFHLQARLMARYIRGDLEGYPPFFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQZ8</accession>
    <name>D6SQZ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870488.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2572"/>
    <dbReference type="EnsemblBacteria" id="EFI35174">
        <property type="protein sequence ID" value="EFI35174"/>
        <property type="gene ID" value="Dthio_PD2572"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="121" mass="13221" checksum="D63A8C2B4DB9BF8B" modified="2010-08-10" version="1">MRVVLDANVIIAAAAARGVCEAVFELCLEQHQLIICEGLEKLRFKINVPAPVVAEYLQLLRNNAETVTPSAVDPESCRDPDDLVILGLVSPGNVEAIPQSPNLFNPDSGSNKRLDFFVFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR04</accession>
    <name>D6SR04_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35180">
        <property type="protein sequence ID" value="EFI35180"/>
        <property type="gene ID" value="Dthio_PD2578"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033AFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2069184at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="115" mass="13007" checksum="CF03D5F27E30F936" modified="2010-08-10" version="1">MRVKAGQRADPSGLTTGKHPGKSGDLRTGRAGTLPSKHEFQKTQVECRSGHKADEYPVAFVFESARLEAAEIIARWYEGGVDPKQPVIDYFRIRSEDGRIFILMYAGHLDQWFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR53</accession>
    <name>D6SR53_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870527.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0492"/>
    <dbReference type="EnsemblBacteria" id="EFI33169">
        <property type="protein sequence ID" value="EFI33169"/>
        <property type="gene ID" value="Dthio_PD0492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="194" mass="22090" checksum="7FCBF185CE656E1B" modified="2010-08-10" version="1">MEKARQFIKKLENIDWMNSANIQQSGDLTIFDDYDGTSASFENSMICAMDILNQWIPKIGDRPEPEDGLGFNHQKQIFEVLYPVTYAKGILKNCIKDGILYVNMKDAMLHNDAVQEWCEQTAVSGANIIFDEESDNLIIAFDIVKDWIDEKNIIAAFVASKLKHDLSSDREDMGFDETEQDLGINLTHLMQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR65</accession>
    <name>D6SR65_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">Dthio_PD0507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0507"/>
    <dbReference type="EnsemblBacteria" id="EFI33181">
        <property type="protein sequence ID" value="EFI33181"/>
        <property type="gene ID" value="Dthio_PD0507"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="130" mass="14673" checksum="34EF839478202A9E" modified="2010-08-10" version="1">MYLLDTNTVIYFFKGQGRVPERLLAIAPGETTVSSITVYEIETGIAKSRQPERLRSNLDQFLSMVVVLPFQTHEAKRAARIRADLEESGMPIGPYDILIAATAVANARILVTRNVREFSRVQGLMVENWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRB0</accession>
    <name>D6SRB0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division coordinator CpoB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cpoB</name>
        <name evidence="4" type="ORF">Dthio_PD0552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CpoB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870584.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0552"/>
    <dbReference type="EnsemblBacteria" id="EFI33226">
        <property type="protein sequence ID" value="EFI33226"/>
        <property type="gene ID" value="Dthio_PD0552"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099900at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02066">
        <property type="entry name" value="CpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034706">
        <property type="entry name" value="CpoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014162">
        <property type="entry name" value="CpoB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02795">
        <property type="entry name" value="tol_pal_ybgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009991222" description="Cell division coordinator CpoB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="245" mass="28428" checksum="0F21D874A1EDEE79" modified="2010-08-10" version="1" precursor="true">MTFRLLLLFPALLLVAGCSSAKRYPPEEMHDISDRLSSLEQKVQEHDQEISNLQTGLGNLRQDTENMRRQTALRIMDLEMQLEREDFVPGPGPENLEPEPVEEPPDPPPAPEKNEKEPDKPASEAKQLYNQALELYFDEQAEQARQAFREFIDTYPEHPLAPNAWYWLAETFYMEKEYPQSILTFRQVLEHFPEDPKAPDALLKIGYAYKRLEDKRNARFYLGVLLEDYPESSAADKARETLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRB6</accession>
    <name>D6SRB6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Siroheme decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ahb/Nir family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870590.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0558"/>
    <dbReference type="EnsemblBacteria" id="EFI33232">
        <property type="protein sequence ID" value="EFI33232"/>
        <property type="gene ID" value="Dthio_PD0558"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="7">
        <location>
            <begin position="66"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="159" mass="18535" checksum="F53FF27BB93837A0" modified="2010-08-10" version="1">MTPVDFSEQEREVLRIVQADLPDTQSPFADIAAMAGISEQEVLDLLQNLKERGIIRRFGATLRHQQAGYGHNAMVAWYVDDTMDIRHVGKIMSRRSEITHCYERASCMDWPYNLYTMVHGRSPEHCTRVVYELARETGVEQYEMLFSYKELKKTSMSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRD0</accession>
    <name>D6SRD0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0572"/>
    <dbReference type="EnsemblBacteria" id="EFI33246">
        <property type="protein sequence ID" value="EFI33246"/>
        <property type="gene ID" value="Dthio_PD0572"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918294at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="148" mass="17195" checksum="D21DFB8E5BA20F4E" modified="2010-08-10" version="1">MEPVNSLLDRFFQRNDPEGRHYLFTRICENWRRIVGGQFADMASPVGRKKHTLILGARDSIIIQELTFQQEELLKRINDFCGVVLFDNLRIELLMGRTPLDIPLVQNTSQKLEPRRPEQLGGLLHAFPEGSSIARCYAKYVEYFNKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRE7</accession>
    <name>D6SRE7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870621.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0589"/>
    <dbReference type="EnsemblBacteria" id="EFI33263">
        <property type="protein sequence ID" value="EFI33263"/>
        <property type="gene ID" value="Dthio_PD0589"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1594801at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="165" mass="19037" checksum="4289A2BA0EA5007F" modified="2010-08-10" version="1">MLIKMEIFGLAMDEKTNMPLVILKDEEDKYILPIWIGALEAMAISIPLKGMSMPRPMTHDLFLDTLNNLGAHLLHVEVTEIKESTYYAVIVLQQEENVLRIDSRPSDAIAMAVRAKVPIMVRQQILEDIMKEQQGDYQVVLDDEESKKWAEILEKFNLDDTKYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRH0</accession>
    <name>D6SRH0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870644.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0612"/>
    <dbReference type="EnsemblBacteria" id="EFI33286">
        <property type="protein sequence ID" value="EFI33286"/>
        <property type="gene ID" value="Dthio_PD0612"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2054097at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11413" checksum="4F647C3DC1662F91" modified="2010-08-10" version="1">MSVLAELSLFPVDKGESLSPYVTRMVRIIKNSGLDYTLHSMGTCLEGEWPEVMDVVDKCFQDLQQDCGRIYLTLKVDYRSGGSNRLTEKVESVHRQLGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRS1</accession>
    <name>D6SRS1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0718</name>
        <name evidence="3" type="ORF">Dthio_PD0736</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870745.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0718"/>
    <dbReference type="EnsemblBacteria" id="EFI33387">
        <property type="protein sequence ID" value="EFI33387"/>
        <property type="gene ID" value="Dthio_PD0718"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33404">
        <property type="protein sequence ID" value="EFI33404"/>
        <property type="gene ID" value="Dthio_PD0736"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="36059" checksum="7345B1478012FA0C" modified="2010-08-10" version="1">MPRNARFTLPHRPTVYHVISRTALSGLPLGDIEKNRLLEIIKYFSSIYFVDVLGFCIMGNHWHLAVKIYPRDYATRQEVQERFVKRYGEDVHFGDQEIEKFSKKWTDLSEFVREIKQTFSRYYNKRHNRRGFFWGERFKSMIVQEGSTLVNMLAYIDLNPIRAGIVKKPEDYRWSSLGYHVQTGNKDGFLSIDFGFKEWNEFDPQEIVRKYRQFVYETGAVDAGKGKTIDQKIVEKARKKGYKVSRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDKRKFTPVGGVEGVYSMKRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRW7</accession>
    <name>D6SRW7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870785.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0767"/>
    <dbReference type="EnsemblBacteria" id="EFI33433">
        <property type="protein sequence ID" value="EFI33433"/>
        <property type="gene ID" value="Dthio_PD0767"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="287"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="433" mass="50104" checksum="4A7CE752E6EA5B7F" modified="2010-08-10" version="1">MQTIIDQLIADFHERELPDVTPRQAGLPWLPGKIDTVIGMRRSGKTWFLYQVMGDLIKEGFPAQAALYLNFEDERLMPMTASDLQQIPDTFYRRYPQLKERQCVYFFDEIHNVQGWELFVRRLLDSENAHICLTGSSARLLSTEIATSLRGRSLTTEIFPFSFSEFLAHEGIDTSMDRQPGSRRRALLENRFISYLSAGGFPEIQGLDDEYRIRVLQEYLDVVVLRDLVERRGISNVVALRYLIRHLMNSPAGLFSVQKFYNDLKSQGIACGKNTLHEFFDYLADTYLFFPVCIHSGSERSRMVNPRKVYAVDTGMIRACSRSTSPDWGRLLENLVFMELRRRTQWIEYYRTQSGREVDFYVQDTSGKISLIQSAAWMEDKKTAQREITALSEAMRECQVPEACIVTFNTEKYVDTDAGLIHVLPAWKWALVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRZ2</accession>
    <name>D6SRZ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0792"/>
    <dbReference type="EnsemblBacteria" id="EFI33458">
        <property type="protein sequence ID" value="EFI33458"/>
        <property type="gene ID" value="Dthio_PD0792"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="327"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="439" mass="49931" checksum="ACA42724C1BE0B6C" modified="2010-08-10" version="1">MAVTFFVPVGSLRAEGPTVLDMEAAVKMGLERNQSLQAVREQVKGREYGTKSARGAFGPSLSSSYGYTRLDERPESRVPTGDPQEPFRTRHGSRDRWELNINIHQPLFTGFNLLSTYEKSKLAHEQSKSQLSRAELELVLEIQTSFLDLLAARESVRVAEDSLTRLNSHLDVSRSFYDVGLVPRQHVLEAKVDVSEAEQELISARNRVDTLESRLNMLLGLPRNMEVVYEGRLEFVPFTLDLDESRDRALQNRPDIFIADKSIQMALQDERITASDMYPHVGATFDVFRRGDDPTVSGSAMEDRSEWRAGVQMQWTLFEWGRTYYAREQARQETRQLVAEYEDLLQNVSFEVKSDYLLIQESRQRIKVARQGLEEAKESYRMAQARYEAQVGTSTQVLDAQANLTAAEARLINAESDFLKAVASIYRAMGEKNISLRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS14</accession>
    <name>D6SS14_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0814"/>
    <dbReference type="EnsemblBacteria" id="EFI33480">
        <property type="protein sequence ID" value="EFI33480"/>
        <property type="gene ID" value="Dthio_PD0814"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="407" mass="42855" checksum="E6BBA78223DC7A88" modified="2010-08-10" version="1">MMHRVVVTGVGIISCLGNDIDSVTTALYKGQSGIEVDPQRQEMGFISPLTGVIRGFEPTRYLGRKQRKTMPDFAVQAHAAVMDALEMAGIDPEQLRDEETGLIFGCDSSCQAAVEQVDYLRRLRDTRSLGSGLIFRSMTSTITMNLNTLLGARGACWSISSACSSGGHAVGQAADLIALGRQKRVICGGAQEINWESMCSFDGLGAFSGRTDEPGGASRPFDAGRDGLVPSGGAAAIILERYDLARKRGALILGEVMGYGFSSDGQHVSSPSSDGLERAMRSGLHQGGLKPSDIDSICAHATSTPSGDSAEAGSITAIFGEHTPAVSSLKSMTGHELWMSGAAQVVYCILMARNGFVAPNINFEEPDETSAKLDIVTESRHAELRSVLCNSAGFGGTNACITLGFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS23</accession>
    <name>D6SS23_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemolysin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870841.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0823"/>
    <dbReference type="EnsemblBacteria" id="EFI33489">
        <property type="protein sequence ID" value="EFI33489"/>
        <property type="gene ID" value="Dthio_PD0823"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1670446at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="FtsJ" evidence="4">
        <location>
            <begin position="65"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="253" mass="28288" checksum="3827A9EAD0725485" modified="2010-08-10" version="1">MRSRKYRADLLLHEQGLAESKEAAKRLIMAGQVYLNLEDREVRVEKPGQALPEDSVLRVQQPERFVSRGGEKLLGALEDFEIRVQDRVCLDVGASTGGFTDCMLQMGALRVYALDVGTGQLHWKLRQDPRVVCLEQINIRKAPASLLPEKVHLAAIDCSFISLKQVMPCVMPFLQQEALVIALVKPQFEVGRGQTVKGVVRSFEAASKAVQGVIDAVTKELDLVLNGWTLSRIKGPRGNQEHLVCFRHESYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS51</accession>
    <name>D6SS51_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870867.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0851"/>
    <dbReference type="EnsemblBacteria" id="EFI33517">
        <property type="protein sequence ID" value="EFI33517"/>
        <property type="gene ID" value="Dthio_PD0851"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="33042" checksum="37850FAFC70FF5DF" modified="2010-08-10" version="1">MKYFILGGTGFVGKQLLDFLLEQGEDVTALVRDESKVKNKSPRLSLVQGDPLKKGDWQNRVSEADVVINLVGSPVMTRWNDKSKKLIESSRVDSTNNVVAAMKDLEPRTFICANAVGYYGPRSDERVDENTGPGNDFLSHVAVKWQEAAQAAEKLGHRVVVSRFPAVLGPGGGAMAQMLPVFRLGLGGKLGSGRQWFPWVHILDLVRALHFMSAKEDISGPVNVCAPQEITNEDFTRAMSRVLKRPAFFKVPGLALKIIYGEVGDMLLTGQRCVPAVLQKAGFEYMFPEIEKALADIVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSC9</accession>
    <name>D6SSC9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">Dthio_PD0930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870945.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0930"/>
    <dbReference type="EnsemblBacteria" id="EFI33595">
        <property type="protein sequence ID" value="EFI33595"/>
        <property type="gene ID" value="Dthio_PD0930"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="291" mass="32697" checksum="DB4F25F00F104043" modified="2010-08-10" version="1">MASFREIQRKIGAVKKTKQITKAMNMVASAKLRGAQQRIERFRPYAEKYYEILSDLSSRVDSSIHPLLEKREEINNVGIIVVTSDKGLCGSFNANLCQMGARLAREKKDQGQQVKFLCVGKKGRDFFRKRGYELLEAYPEVMNNFDFQLANDIGTRVINSYLEKDLDEVHLIFGEFHSMVKQVPTASQVLPVVQAEVAEAEGPQSEYLFEPSVEGLLAEILPRYIKVQVYRGLLDTSCSEHAARMTAMDNATKNCDEMVDQLTLAYNKARQAAITTELMDIVGGAEALKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSU5</accession>
    <name>D6SSU5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871110.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1100"/>
    <dbReference type="EnsemblBacteria" id="EFI33761">
        <property type="protein sequence ID" value="EFI33761"/>
        <property type="gene ID" value="Dthio_PD1100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1889182at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018704">
        <property type="entry name" value="TPR_21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09976">
        <property type="entry name" value="TPR_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_21" evidence="3">
        <location>
            <begin position="30"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="222" mass="25228" checksum="199FF4ECE5B41EC1" modified="2010-08-10" version="1">MTDPGNRKGFLDRLMSEADETAHPLLQKIQEYQKMILTVVVAVVIGAASYSGYTFFTERAQQQAQEEMNEILAMQDQEERIQALEKFLEDAPGAMQGGALFELTRIYMDTGKYQEAADAFSRLEKKDDSLQPLALLGRAKAYELMQDYARALEILQEAGDEFPREFINQYHTQKAFVAEQAGDYQQALESYQSLKELAHGADDGFIRYKIDSLRKKTEQQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSV1</accession>
    <name>D6SSV1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871116.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1106"/>
    <dbReference type="EnsemblBacteria" id="EFI33767">
        <property type="protein sequence ID" value="EFI33767"/>
        <property type="gene ID" value="Dthio_PD1106"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1752865at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025707">
        <property type="entry name" value="DNA_bp_PD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016702">
        <property type="entry name" value="DNA_bp_PD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="15375" checksum="43C8579FDFAC4AB9" modified="2010-08-10" version="1">MQYRQAGEKWFIRIDRGEEVLEVLASFCREQGITLGSISGIGAAGEIKLGLFETASKTYQSTELKGDFEITALAGNVTTKEGQVYLHVHATVSDKECRAFGGHLNRALISGTCEVVIDQAQGSIERRFDDDVGLNLMKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSY6</accession>
    <name>D6SSY6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bifunctional adenosylcobalamin biosynthesis protein</fullName>
            <ecNumber evidence="12">2.7.1.156</ecNumber>
            <ecNumber evidence="12">2.7.7.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD1141</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 12">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 12">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="12"/>
    <dbReference type="EC" id="2.7.7.62" evidence="12"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871151.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1141"/>
    <dbReference type="EnsemblBacteria" id="EFI33802">
        <property type="protein sequence ID" value="EFI33802"/>
        <property type="gene ID" value="Dthio_PD1141"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903913at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="13">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI33802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="171" mass="19232" checksum="54F75AC916FB0FEE" modified="2010-08-10" version="1">MNRVTYICGGCRSGKSSFALQLMQTFERKAFIATAEALDEEMHQRIQRHQQERGQSFFTVEEPLDPAQALSRLPGDTQAAVLDCLTVWLGNLMHQELVQEDTCPQLENFFALLAAPPCHVFVVSNELGMGLVPGDSLSRRYRDMMGRINQRTASLAHEAYFVVSGMPLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST14</accession>
    <name>D6ST14_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871179.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1169"/>
    <dbReference type="EnsemblBacteria" id="EFI33830">
        <property type="protein sequence ID" value="EFI33830"/>
        <property type="gene ID" value="Dthio_PD1169"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="201"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="407" mass="47483" checksum="C5EEF59405C02ADD" modified="2010-08-10" version="1">MIKRETYINRVRPFINKDMVKVFTGIRRSGKSTLLKLVQQELIADGVSENQIIMINFESMAYANRDFMSIYQELRHLSGNHGEKAYIFLDEIQELAGWEKMVNSLRVDLYCDLYITGSNSKLLSGELATYLAGRYIEVAVYPFSFQEIMKIKKEKQTELPVEEAFNLYLRFGGMPFLYENNLDATAALDYLKDIYNSIMLKDIIGRHAIRDVELFERILSYLLANVANPFSGSNIMKYLKNEKRAISLETLYNYISYSQEACLLYLTPRENVQGKRILKFQEKIFLADHGLREAIYGNNQRDINQILENIVFLELLRRGYTVRIGKSDAKEINFIAEKMSQRIYIQVAYLIPDQNVAEREFSALLGIKDNYPKMVLSLDKFDLSRKGIVHKNLINFLLEQDWRINTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST74</accession>
    <name>D6ST74_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH/Ubiquinone/plastoquinone (Complex I)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871239.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1229"/>
    <dbReference type="EnsemblBacteria" id="EFI33890">
        <property type="protein sequence ID" value="EFI33890"/>
        <property type="gene ID" value="Dthio_PD1229"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="144"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="503" mass="55645" checksum="E9645FC686A37D2A" modified="2010-08-10" version="1">MIPSILLQIIFVPALVALVILLFRFQLGMKAGWVAVAGLAYTTFLLLLAFFEVYKGTPITETYQILKSPEISITLVADGLSIAVAFICNLLCLALGTYSIKYIYHRIEVLYPDTIGNRGEISWYACFYYLFLFFPVGFMGVSFASDLVLMYFFLEVLTLFLFFLMAYFGYYERVWVAIICTVWGIFSALFFLAGVALIYSQTGSLQIEQIHTMSGDPLAFWAILLVLVGMIAKLAIVPLHVWMPWVHAEHPTCIAGLLAVYANIAAYIIVRMLVLPLWEDFQVFGPYIMVLAVITMIYGSLLTLAQRDMKRIPACSTISQSAYSMLGIGALTAASIEGGLFFFLSHIMGKTVFFSACGLVVYMTHIRNVKYLGGLGAKMPITALVFLSGGMMLAGIPPFSSFAAEVVMFAGIFERGDTFGLVIGIIGLLAILLSISYAVHFTRIIFFGPLPEKLANDDHIKDPPWVMLAPLIVIILFSAFLGLYPTLVMELFEPVISTAIANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST97</accession>
    <name>D6ST97_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871262.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1252"/>
    <dbReference type="EnsemblBacteria" id="EFI33913">
        <property type="protein sequence ID" value="EFI33913"/>
        <property type="gene ID" value="Dthio_PD1252"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040084">
        <property type="entry name" value="GTPase_Obg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01083">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="10"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="311" mass="34697" checksum="44710E00424179BE" modified="2010-08-10" version="1">MADYLFGPVMSSRLGRSLGIDLLGDRICSFDCLYCESGPTTQKTIVRREYADSGIILAELEKWLNDNQGDKPDHITLGGEGEPCLNLQLGKIIRDIKKIEPDIPLAVLTNSSLLGDPQVRKELRNADVVLPSLDTLVQEEFIRLNRPCAGLDIQEIARGLEAFCKEFSGRVLLEILLVPGINDSRENMEKITVFLKNLDHERVDLSVMSRPGAHMQLKTPDHETLHRWQKALHTPLTGAETGTGPGTRGRAASVSTIMDSIRRRPQTLEQLCSALGTAPEETSAMLDELVQEQKVRALGHRKEKFYTLKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6STA4</accession>
    <name>D6STA4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD1259</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1259"/>
    <dbReference type="EnsemblBacteria" id="EFI33920">
        <property type="protein sequence ID" value="EFI33920"/>
        <property type="gene ID" value="Dthio_PD1259"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003161">
        <property type="entry name" value="FliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00207">
        <property type="entry name" value="fliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="12">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="11">
        <location>
            <begin position="116"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="10">
        <location>
            <begin position="219"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="335" mass="36948" checksum="775364176216FF6C" modified="2010-08-10" version="1">MPPEKLSGVQKTAILLLALGDSFTAEVFKRLDKNEITSVSKAMLEMESVPKEKAEEVLKEFNQTLVAGKEMLMGGPDHVKRMLTKLLDSDTAKYVMDALELDTGPAPFRELINVSPKILSQILRNEHPQTLALITGHLPSENAAELLQNLPHGIRTEVLMRLARLEAVPEDMLMEVDKVLQNQLIAIGAKEGRKVGGVQAVAEILNSVERSVEEEVLSDIEEESSQMAEDIRQLMFVFEDIQALDDRAVRELLKEISNEDLTMALKTSSEELKSKFLSNLSERAAGMIQEDLEIMGPAKLSDVEAAQQNIVKSVRRLEAEGRIVIAGKGGGDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6STB2</accession>
    <name>D6STB2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1267"/>
    <dbReference type="EnsemblBacteria" id="EFI33928">
        <property type="protein sequence ID" value="EFI33928"/>
        <property type="gene ID" value="Dthio_PD1267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="62"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="313" mass="34206" checksum="B2C9690E654EA283" modified="2010-08-10" version="1">MCTTAGAVAGLGITGIEAAGGPAAVSAADADSKDMPRRKLGRTGHQVSIFSLGGEATVQQSGRQDEAEAIIDKALDLGVNYIDTSPTYGGGGSESNIGQVMSRRRKEVFLASKTQDRTYDGTMRLIEQSLKRLQTDYLDLYQVHSVRVNDDVDQALGRQGAVRAMEKLKSEKVIRNMGITGHKDPDVLIRGITRHDFDTVLLTLNAGDIHYRPFQEDLLEKAAEKQMGIIAMKVTAVSRILKPGGAVSMQEALGYTLSFPVSTAIIGISSLEEVEENARIAREFEAFSSDELARIEDKTRPHQDQANFFKHHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STG8</accession>
    <name>D6STG8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein involved in aromatic hydrocarbon degradation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OmpP1/FadL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871333.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1323"/>
    <dbReference type="EnsemblBacteria" id="EFI33984">
        <property type="protein sequence ID" value="EFI33984"/>
        <property type="gene ID" value="Dthio_PD1323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="620166at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005017">
        <property type="entry name" value="OMPP1/FadL/TodX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35093">
        <property type="entry name" value="PTHR35093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03349">
        <property type="entry name" value="Toluene_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088071" evidence="8">
        <location>
            <begin position="24"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="421" mass="47271" checksum="22B56AEF0ADDCBE9" modified="2010-08-10" version="1">MNWKRVVVLFLFMCFGYGGSVHAAGFALYEWGARGTALGGTMIGRADDASAVAYNPAGITQLEGTRTKLGFSVVAPGGDIRTTDETGNTETTSIESNYWIPPHAFLTHQLTDQAWLGLGIYSRFGLGTEYPDDWPGRYNSYYNRVQSLSFNPNLALKISDSWSMAFGIEVMWFDFKQERAVNGQAFGLSDIDAEVHGDSFGFGANAALHYKPSDTWAVGLTYKSRVKQTVSGDAKFDRPAGTPPGFFQNTSAEGDITLPDSFGLGVMYRPLERLTLEANAIYTLWSTYDELKIEYSEPLFPGFEERAIDKKWEDVWRFQFGAEYDLTELIDLRLGYVFDQIPDRDKYADYMTPTNDRHIITSGIGFSWDQASLDLSYSYLWFANRSIDARDSTDDGTIDILDSRFKDGHTHIGSMSFSYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6STJ5</accession>
    <name>D6STJ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871360.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34011">
        <property type="protein sequence ID" value="EFI34011"/>
        <property type="gene ID" value="Dthio_PD1350"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8578" checksum="17C0B64EFABC2850" modified="2010-08-10" version="1">MKTVTASEANRSFSSILRGVAEGESYTIISRGRAVAAIHPGAPEAAQRRQAKSILLERLNHQPITGNRQWTREELYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6STL4</accession>
    <name>D6STL4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="3 13">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lpxK</name>
        <name evidence="14" type="ORF">Dthio_PD1369</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the LpxK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="3 13"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1369"/>
    <dbReference type="EnsemblBacteria" id="EFI34030">
        <property type="protein sequence ID" value="EFI34030"/>
        <property type="gene ID" value="Dthio_PD1369"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="341" mass="38740" checksum="1C34615C17F5108C" modified="2010-08-10" version="1">MHAASRIYARAMSLRQHYLLRRAWTAPVPVVSVGNISMGGTGKTPVCAFLLKHLLAWGQRPVLLSRGYKARPPHYPHPVHPLDDPGCCGDEPLMLAQIPGRLRVVVDPSRKRAAGWALRHLRPSVFVLDDGFQHLRLHRDLDLVLLTARDLQEDWDRVFPGGRWREGVQALKRADLFLVNTRDKSVDEMKSLADGRLRDFRKPVIFFRIKVNSLQRLGDKISTYNIQSRQYLLISAVAGPEKIFSSAWDFLGYPPVKHLIFPDHHPLERRAVQEIFQSARKMGVQDVLCTAKDAVKLRPQAGLNFWILQTGLLFSENGEETLLEVVRHACSGIEKQVRPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6STL8</accession>
    <name>D6STL8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribulokinase</fullName>
            <ecNumber evidence="3">2.7.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoribulokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.19" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871383.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1373"/>
    <dbReference type="EnsemblBacteria" id="EFI34034">
        <property type="protein sequence ID" value="EFI34034"/>
        <property type="gene ID" value="Dthio_PD1373"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008974">
        <property type="term" value="F:phosphoribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006082">
        <property type="entry name" value="PRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00478">
        <property type="entry name" value="PHRIBLKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="4">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="308" mass="35435" checksum="CD5CEFB8F50FB00E" modified="2010-08-10" version="1">MRRTKPIILGIAGDSGSGKTTLARGIRQILGNEIVTGICIDDYHKYSREERKEQNLSALHPDCNYLDILQSHIAELRRGKAILKPVYDHSKGDFSRFKYVEPADFIVVEGLLAFHIKKLREMFDVKIYLDPEDFLRETWKIQRDTSERGYSEREAKNTLHRRAELSTRYIRPQREHADIVLNFYPPPELPGETGSRLNARLILRPTIRYPDFSQFIDQDQEADENCLSFTLGRDSGTPVDLLHIQGNISQDTLEYTSRLILEHLSEAGPTSLENIGRYLEGKTPRKSYPLALAQLLVGFCLHKLKINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6STM6</accession>
    <name>D6STM6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871391.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1381"/>
    <dbReference type="EnsemblBacteria" id="EFI34042">
        <property type="protein sequence ID" value="EFI34042"/>
        <property type="gene ID" value="Dthio_PD1381"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="211"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="435" mass="48778" checksum="7915DB2B95BCCA79" modified="2010-08-10" version="1">MNNCRGSPQEDIEAAAIRSAVRLLTDITVPLNERLDKSLDFILKRIKASKGSIMLKSSEQESLRVEASTNHNIIGIVQDINPGSISGYVFYNSVPLMIEDISKSDMFKPRNGRSSSYRTTSLLCVPLQGSQNNTIGVINCSDRDNDSPFTSQDFQMVQEYASWISPLVENSCLMDKIREEKERYKALVRELELKQRELLIAHTERSELVQMVVHDFKSPLSAVISNLDLLKYMGVNQNQDHVVQTARNGASKLFEMINEFLEVARLDQWSEENKGRLAPVDLLPVVQQVVQEAWSTLASKSLALTLDQAQDIKVVADNMLLSHLLGNLISNAVKYTPEGGLVKVWWEVLESRRSADKYNRLVKIGVQDNGPGVPDDLKNKVFDRFTRAERDKNIQGTGIGLFICNRIATMLEGHIWVEDAPGGGSIFCVTMYSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6STR0</accession>
    <name>D6STR0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871425.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1416"/>
    <dbReference type="EnsemblBacteria" id="EFI34076">
        <property type="protein sequence ID" value="EFI34076"/>
        <property type="gene ID" value="Dthio_PD1416"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8823" checksum="AD339F43B73126DE" modified="2010-08-10" version="1">MDTINVHEAKTHLSRLIQKVLQGEEVIIAKKGRPLVRMVPFDQSRQKRVPGLSKGSIKMRENFDEPLPDDIIRAFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6STR1</accession>
    <name>D6STR1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1417"/>
    <dbReference type="EnsemblBacteria" id="EFI34077">
        <property type="protein sequence ID" value="EFI34077"/>
        <property type="gene ID" value="Dthio_PD1417"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="441" mass="49200" checksum="945A6DE781BD715A" modified="2010-08-10" version="1">MQSSRYHLLGRGVNAGLERGLDRKTVILGLDGLSLGLAGSLCRKGVWTNMKELLDSGSCMGITSELPEVSPVNWASFFTARGPEEHGVYGFTHIDPQSYQMGLTDFSCVRTDTVWDYLARAGQTCRIINLPCTYPAPELKGMLVSGFVAPSLERAVYPGALYPILSQKGYRLEADTTLGLDRPDRLIEELHLTISSRLMALDLFWPDQAWDLFIIVFTELDRLGHFLFHALEDEKHSLHSDCMGLMKSLDRAAGEVLSRFEDLPGPKRLMCVADHGFAGLITEVDVNALLMAEGFLSLSRPPGDELDPGCMHPESRAFALDPGRIYIHDRGRFARGRVDQVERAEVIRQVRECLQALEYQGRKVMDHVYTADEIYPGGAGMPPDILCVPGAGFDLKAKFDRREVFGHFGRTGTHCRDDVFFYDSHGYSPGRVRDVLRLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6STT2</accession>
    <name>D6STT2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1438"/>
    <dbReference type="EnsemblBacteria" id="EFI34098">
        <property type="protein sequence ID" value="EFI34098"/>
        <property type="gene ID" value="Dthio_PD1438"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="18839" checksum="963F2196119F31CD" modified="2010-08-10" version="1">MNTQEALQVLKPDAATLEALKQAYRAAARKYHPDINPHGEELMKLVNAAYDLLVSSLGEWAIHENAAEDPGEMSLDEEMSGILSKIGHFPELLFEICGTWLWVTGNTYLHRQALKDAGLFFAPKKRAWFWRPPESKTSSRGQWDLDKIRTVHGSRPIKNQSLQGLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6STT9</accession>
    <name>D6STT9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871454.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1445"/>
    <dbReference type="EnsemblBacteria" id="EFI34105">
        <property type="protein sequence ID" value="EFI34105"/>
        <property type="gene ID" value="Dthio_PD1445"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2022621at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="179" mass="20036" checksum="1099FA94BFB77BF9" modified="2010-08-10" version="1">MKNEKTSPPVPPQHQGRISNVDELLRAIEAYFDSCDDQGMSYTLAGLQYYLGVIDKQLLWGEQVGKSSESKETVALFKDPEVRRALQVARLRIQAQRATQLLDDEKNTQAQIFDLKANFAWVDKQGLEVTSPDNSVGNKVAVVLPANPGSVTMDQWQEMYKQVMANRKSVHELRVGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6STV0</accession>
    <name>D6STV0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein GSU0053</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871465.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1457"/>
    <dbReference type="EnsemblBacteria" id="EFI34116">
        <property type="protein sequence ID" value="EFI34116"/>
        <property type="gene ID" value="Dthio_PD1457"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8KS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="950114at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013403">
        <property type="entry name" value="CRISPR-assoc_prot_GSU0053"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09617">
        <property type="entry name" value="Cas_GSU0053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02570">
        <property type="entry name" value="cas7_GSU0053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="324" mass="36157" checksum="6A62926F021BF85B" modified="2010-08-10" version="1">MFEVLKNAKRLLLEADLEPVQGDRFQPTGFPDIGAGTYLLPDGTRKIVLESPQSMANRLESTVIGPDSELIKDFDGLPYVRVSLEGATDAKTNSLMEAHRLNSPFIITDKDFQQAFKQEADYEKGKPLDWRKIARTIFKYDVNSILHGVFLANLEDGRVKMPRAVSSFIEAIDAKEVVYGGVKNNPIDPTGKIRAAEHDKDVYGNVPYQRVEYTASNIKAFFNFDLGMIRSYELGDEAENLLIGLGLYKIRSFLEGGLRLRTACDLELKDGNALMVKEPEGFTVPGSAELKKSVQNQITECKDKELFAQPPVTQINTETVLKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU00</accession>
    <name>D6SU00_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871513.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1512"/>
    <dbReference type="EnsemblBacteria" id="EFI34166">
        <property type="protein sequence ID" value="EFI34166"/>
        <property type="gene ID" value="Dthio_PD1512"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="39779" checksum="C6A32FD23E0BC74B" modified="2010-08-10" version="1">MSKKIPNAHDLCFKSFFSREDFVRDFIQYYLPEEVKKHLDLTIIEIDMEGYLSEEFKEFYSDVVAKVYFKDRIHELELYFLFEHKSKPYRFTILQTLNYQVQKWMRLLVDGKLDQYLPIIVPVVIYNGYKGWNFSVQFEDLFQLPSEHFKDFIPQFRHILHDIGQMDEASFKTTTIMEIFHLLLKYIYYPELDTKIHEIYDLLEKLPDNDKLTDYLFIIVRYVMASGAIPEKRLLEHTKRFSGGEEMIGVAAREIEERVEQTRKPYWQKQAKVENSQENLIDVATEVYGPLPGMLHEKIKSIQSLENLRALNRKVIRTQSLEEFTELVNRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUB2</accession>
    <name>D6SUB2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, CarD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871585.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0206"/>
    <dbReference type="EnsemblBacteria" id="EFI32892">
        <property type="protein sequence ID" value="EFI32892"/>
        <property type="gene ID" value="Dthio_PD0206"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942592at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="177" mass="20012" checksum="2B9186DC05FC928D" modified="2010-08-10" version="1">MFSVGELVVYPAQGVGRVEKIEEQDLGGAKAVLYIVRILSNNVTLMVPVNNADNVGLRPVSGKGQGQEILSFLEDRSDFTGYSGQNWNRRYREYSDKLKSKDLQDVAYVLKELFLISRDKELSFGERRLMEQAMGLISMELSYALSIDQEEAKSRVEALFADILSPEVQEHDDQEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUB5</accession>
    <name>D6SUB5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Sec translocon accessory complex subunit YajC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yajC</name>
        <name evidence="11" type="ORF">Dthio_PD0209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871588.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0209"/>
    <dbReference type="EnsemblBacteria" id="EFI32895">
        <property type="protein sequence ID" value="EFI32895"/>
        <property type="gene ID" value="Dthio_PD0209"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2082059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI32895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12316" checksum="BEF7E2674152C21E" modified="2010-08-10" version="1">MLLETMIFAMGADPEGGAGNPLAAFVPLILMFAIFYFLLIRPQQKKAKEHRNVLANLKRGDNVLTNGGVYARISDIQNDVLTLEVGDKTTIKANRNYIAGLADPNQDAVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUC5</accession>
    <name>D6SUC5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871598.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0219"/>
    <dbReference type="EnsemblBacteria" id="EFI32905">
        <property type="protein sequence ID" value="EFI32905"/>
        <property type="gene ID" value="Dthio_PD0219"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="364" mass="41014" checksum="574C8EF0BFA6243B" modified="2010-08-10" version="1">MHLIAEWFKRHFGNQQVVILVGLLLFFFGVVYFFGQMLLPFFAGLVIAYLLDGMVKMMTKYGIPRLLAVILVFLGFMLIMFFSFFWLVPMLIKQVTQLVQQLPSMISEAQMHLLQLPERYPHLVSQEQIQEVISALRTEVAQLGQQILSISVASVVGLITILVYLIIVPLLVFFFLKDKEMLLAWFTRFLPRERSLAVQVWEDVNRQISNYIRGKTWEIIIVWGATFAVFSFFGLQYSVLLSLAVGLSVLIPYIGAAVVTVPIALVAYFQWGFGSEFVWILVAYAIIQALDGNVLAPLLLGEVVNIHPVGIVAAIFVFGGLWGFWGVFFAIPLATLVQAVIRAWPRAEDVKKQAIEPPGDPGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUQ1</accession>
    <name>D6SUQ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871724.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0345"/>
    <dbReference type="EnsemblBacteria" id="EFI33031">
        <property type="protein sequence ID" value="EFI33031"/>
        <property type="gene ID" value="Dthio_PD0345"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="146" mass="16252" checksum="BA0C817D66DAF6CD" modified="2010-08-10" version="1">MLTVKDLMTRDIFTLQATDNLALARSLMDLARIRHIPIVDHDMCFTGLITHRDILSATVSKLAGVDSQTQEELDMGIPVQEIMNTRVKTIHPDDNLRDAASLLLEHKYGCLPVVMDDKLVGILTEADFLSLTISLMDALGEDHELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUQ4</accession>
    <name>D6SUQ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871727.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0348"/>
    <dbReference type="EnsemblBacteria" id="EFI33034">
        <property type="protein sequence ID" value="EFI33034"/>
        <property type="gene ID" value="Dthio_PD0348"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="266" mass="29288" checksum="A2996EEFE6155A7F" modified="2010-08-10" version="1">MSRVISFSNYKGGVGKTTSVVNTAHILVLQGYKVLVVDLDPQGNSTLTLSRSNPFEHEYSVGNLLADRDLATEKCLVHTPYNVDLIPANLNTYSLVAGLPANSAKRIFGLKNRLAELAETGRKHDYILVDCPPQIEGALITNAIAASDYYILPIEGESVYALQGVGHLMQAMEAIREDSNSGIRLLGALITMFDGRTTAGKTVREAIEQYFQDLLFKSVVRRNTAINKANLSNRCVCDMEPRSAGCLDYMAFAREMVARLDQMQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUQ9</accession>
    <name>D6SUQ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="14" type="ORF">Dthio_PD0353</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871732.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0353"/>
    <dbReference type="EnsemblBacteria" id="EFI33039">
        <property type="protein sequence ID" value="EFI33039"/>
        <property type="gene ID" value="Dthio_PD0353"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006316">
        <property type="entry name" value="Trp_synth_b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF6">
        <property type="entry name" value="PTHR48077:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500824">
        <property type="entry name" value="TrpB_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01415">
        <property type="entry name" value="trpB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="76"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI33039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="447" mass="49304" checksum="92CE1D4E553E2B15" modified="2010-08-10" version="1">MQQTKILLEEKDMPTSWYNVMPDLPEPMAPPLDPETKKPIAPEKLSAIFPMSLIEQEMSGERWIDIPEPIQEIYRLYRPSPLVRARRLEQAIGSKARIYYKDESVSPAGSHKPNTAVAQAYYNKMEGVRRLATETGAGQWGTALSFACKMLDMKCTVYMVRCSYDQKPYRGIIIRAYGGEVFPSPSRHTSVGRKVLEQDPNSGGSLGLAISEAVEDAAQNNDTKYALGSVLNHVIHHQTITGLEVKKQLEIAGETPDVLIGCVGGGSNFGGLVLPYMPEKLEGQKIRFMAVEPQACPTLTKGRFAYDYGDMARQTPLIKMYTLGHGYFPPPIHSGGLRYHGEAPIVSHAAKLGLLEARAYFQNEVFDAARLFMQTEGFLPAPETAHAIKAAIDAAKEADPGQVVVFLYSGHGLLDLGSYDAYLKGELKDQAFSDDEIEKSLSECPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUS9</accession>
    <name>D6SUS9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871752.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0373"/>
    <dbReference type="EnsemblBacteria" id="EFI33059">
        <property type="protein sequence ID" value="EFI33059"/>
        <property type="gene ID" value="Dthio_PD0373"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="237" mass="26668" checksum="5711549A2E4EF34D" modified="2010-08-10" version="1">MFQHVTNEKRSVFIINQIRSNILMGRLKPGDRLPSEQKLMSEFGVSRFTLREALSSLETMGLLEIKKGSGGGPVVKEVGMDFTRDAISHFLHFQNVSIKELSEVRKLIEPYLASKLVEKLSDKDLEYLQSLNDACSRTLERGENIIGGEHEIDFHVHLARVSGNPVLVMILDFVNKLLAEVKVEVKPGPDFSQHVVDAHQRILDALVARDAEKAAQAMYDHVCDVEKEMLGIMESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUT8</accession>
    <name>D6SUT8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylase_S domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871761.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0382"/>
    <dbReference type="EnsemblBacteria" id="EFI33068">
        <property type="protein sequence ID" value="EFI33068"/>
        <property type="gene ID" value="Dthio_PD0382"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2069556at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="203" mass="23545" checksum="7FAEC98FD1AE5F92" modified="2010-08-10" version="1">MPSDTEQTRLVKLKEVAKITAGLPARKKMEEDPQGNMRVIRPKDTAAWRRVNHDELIRIRFKGRKIESYFLKPGDILFFGRSGQSHSVVLESPVPENTAAAPSFMVLRIKDDKTLPHYLNWYLNSDRAQKYFMAEAGGSFQRVVTKSVLENLEVPLPEQNDQERIVRIWYLWLKEERLTRQRLKHREEMVQVGIDGILGGGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUY7</accession>
    <name>D6SUY7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0030"/>
    <dbReference type="EnsemblBacteria" id="EFI32743">
        <property type="protein sequence ID" value="EFI32743"/>
        <property type="gene ID" value="Dthio_PD0030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="338" mass="39659" checksum="BCADC8E11865ADC9" modified="2010-08-10" version="1">MSTTNIHDSTIKYFLSDRLNAISLLKSMLPEKIVKQLNFNKIYYEKDSYLPKSLQGYYSDLVVSVPTKCGLYVAKVFFLLEHKSTFKKNTPLQFLRYILEFWEQYQKNTGETRLPVIIPILIAHPEEGWKPTKVSDLVDLPSDDFKIFVPDFNFLLYDAVNDDPEDYDFDETLKALFTLWRYSGSPEFMQGVQKAFQLIKKVDPKARLLDFVQMILHYLEVTRDEKEYIDIKKIAETEIDEGEEYMGTIAEMFRREGDERTEQRFLQEKPIWEKQSELKATQETLIDVAGDFHGPLPNSLQDKIKSIDSIDSLRTLTRKFYKTQSLEEFTELVNRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV29</accession>
    <name>D6SV29_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871874.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0082"/>
    <dbReference type="EnsemblBacteria" id="EFI32785">
        <property type="protein sequence ID" value="EFI32785"/>
        <property type="gene ID" value="Dthio_PD0082"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1335357at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="209"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="45837" checksum="73E6E19148FBAEB3" modified="2010-08-10" version="1">MLDRQIQDYLEWMNNAGYAPWTMAQHSQILNRLLDFVVLNSIPWERTFARDTLQAFKDHVQVKYAGFVLRGFMRYLHQNGIICLPPGALPEGRGRSKLQRARLPRVYEEYLQFYTQTRQVGKQQIYRVQGTLSALNDYLQNQDMGLKDLDVLHMDAFLAERNRKYAPETRIHERSGLRGFLRYLYLERQILKKDLSALIQGPPVYAQSRPPRFLTLEQIKTLFQSIDKDRPGGLRSYAMIHLAYSLGLRPGEICRVTLDDILFRDKLIYLPDRKNSSPAKLPLPQGALRALAAYLAWNRPMDPGHRFLLCNTRTPYGPLTPLTVSQNISACFRRAGIKGSAYWLRHTYAQNLLQAEASIFEIKEMLGHDIIKTSKRYLHVHTRLMREVLFNEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJW4</accession>
    <name>D6SJW4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869289.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3623"/>
    <dbReference type="EnsemblBacteria" id="EFI36167">
        <property type="protein sequence ID" value="EFI36167"/>
        <property type="gene ID" value="Dthio_PD3623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="7958" checksum="6485ECD4D9A74200" modified="2010-08-10" version="1">MIKTCRNCLNNQEFSDVLVNGVLLRDPQYCQRADEMLPRIGNAVVPVLDDRDVDEPTDCPYWEDADENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJY0</accession>
    <name>D6SJY0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869305.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36183">
        <property type="protein sequence ID" value="EFI36183"/>
        <property type="gene ID" value="Dthio_PD3639"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032066">
        <property type="entry name" value="GP3_package"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16677">
        <property type="entry name" value="GP3_package"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17237" checksum="EC8577566A7643AC" modified="2010-08-10" version="1">MASRKKGRPRKYRNADQLQEKIAEYFHSCSERGKIPTKAGLCYYLGFADPAALSYYADRCKARNHFSKAIRKALVKIEAWKAQALVDGELEPGRLRGLCFDLRCNHGWREKTAVKTEEPDVGGSGVAVIGWHRWENYCRRRLAQSSPASDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK02</accession>
    <name>D6SK02_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3662"/>
    <dbReference type="EnsemblBacteria" id="EFI36205">
        <property type="protein sequence ID" value="EFI36205"/>
        <property type="gene ID" value="Dthio_PD3662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10520" checksum="561917CADA7EAAF2" modified="2010-08-10" version="1">MLGGLLGLFHESEKNDHFLPDDKAIKCTSNAFASPRPQFEKSASHAARVRHAQARPKLDQKFNQSRVVGKDANRPVFNLISDLGVEILNRAEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK08</accession>
    <name>D6SK08_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ORF">Dthio_PD3668</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869333.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3668"/>
    <dbReference type="EnsemblBacteria" id="EFI36211">
        <property type="protein sequence ID" value="EFI36211"/>
        <property type="gene ID" value="Dthio_PD3668"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1358620at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="173"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="322"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="191"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI36211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="439" mass="49738" checksum="B8386708C619A004" modified="2010-08-10" version="1">MEQKIHLFGLSHKTAEVEIREKFALTGFNPVSLELISKDGPVYEALVLSTCNRVEILCVGNQDQEQVKGKVLESWAGFCGAEKDLLSRHIYHYTDREAVRHLFTVAASLDSMVLGEPQILGQLKDAYRKAVEERSTGVIINRMMHKSFSSAKRTRSETAVSSSAVSISYAAVELAKKIFGELDTHKAMLIGAGEMAELAALHLLNQGLKEIMVANRTLERAQELARRFGGQAMCLEDIFDYLHHIDIIISSTGSTSAIIRARDIREVLKKRKNRPMFFIDIAVPRDIDPDVNQLDNVYIYDIDDLQEVVEENLAGRKEEAQKAGEIVEQEVDKFEKWLNSLDLSPTIVDLLNKGESIARKEVRKSLRNLPPDTDERTVQTMEHLAESLVGKLYHEPIVFLKRRAREEGSSEKYIDLARKIFNLDEEQIPDNPHAEKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK61</accession>
    <name>D6SK61_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ion transport 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869383.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3727"/>
    <dbReference type="EnsemblBacteria" id="EFI36264">
        <property type="protein sequence ID" value="EFI36264"/>
        <property type="gene ID" value="Dthio_PD3727"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="367769at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="4">
        <location>
            <begin position="262"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="354"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="4">
        <location>
            <begin position="481"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="567" mass="63523" checksum="C59F911F6D8089F1" modified="2010-08-10" version="1">MKLIPSILEYFFEDKTAKNNILALLKFLLVLVVMMVLYTLLFHWIMVIEGQEHTILDGLYWTAVTMSTLGYGDITFHTDLGRMFSVLVLLSGVIFLLVMLPFTFIRFFYAPWLEAHNKARTPRELPEKTAGHVLLSNFDPMITNLVEKLKQYNYNYCILVPEQQRTLELHDQGYKVMLGELDDLKTYRKSRADKAELVLLNNDDHTNTNAVFTLRELSSNTQVIATAETLESVDILQMAGASQVHQFPVMLGQALARRVLGVSMHANVIGRFGDLLIAETPVMRTPLEGKKIIESKLRETTGVNVVGIWERGSFKIPHPDMRIGSNTVLVLAGSQDQLEKYDEIYGIYNLSFSPVLILGGGRVGRAAAETLAESDIDYRIVEKSSRIVASKEKYVHGNAADFHTLKRAGIDKAPSIIITTNNDDLNIYLTIYCRKLRPKMQIISRATRDRSVSKLHQAGADLVMSYASMGANSIINHIKGDNVLMVAEGLDIFREKVTGNLHKKTLGQSDIRMKSGCNVIAIESPVRGTIINPEPDSPLEEGDELILIGTSEAEKKFLCTFKNGNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK89</accession>
    <name>D6SK89_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869411.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36292">
        <property type="protein sequence ID" value="EFI36292"/>
        <property type="gene ID" value="Dthio_PD3755"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2200139at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8788" checksum="23330B5972499010" modified="2010-08-10" version="1">MSSYSETPYQTAIDAIEALPIEDRREVIELLRLRMAEERREQIAANAAETLHAVREKKSEFGTLQDLRKDLLRSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK91</accession>
    <name>D6SK91_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869413.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3757"/>
    <dbReference type="EnsemblBacteria" id="EFI36294">
        <property type="protein sequence ID" value="EFI36294"/>
        <property type="gene ID" value="Dthio_PD3757"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1425742at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="372" mass="43115" checksum="63AB8A1205057FCE" modified="2010-08-10" version="1">MVKWLHSLRRKIKEQHASIIYPHEGFLPPSQDTFAAIGELSRVVRNNPDAVEIYLALGNLFRSQGEIERAIQIRTNLIARPHLEAQFKARAWYELGLDYKRAGILDRAQAALEQAHEITGDDPAVIKEMARLAADSTNFSTAAQYYALLEQPLPQAHYLVRAARQEEEKSKDDRAGYKLIEKALKVYPGSVEAWVEIVCRDYRHQNWTNLRFDLKSGLQNVQRELRFVLLEGLFQFIAARSSAGDNLQEQFECSSIVVNTVSELEQDMVLCYYCAIFMKQCGRYTECLEWLEKTLVLGPDFWPARLEMLELSLDHQVLTESFKAQLMFFTRRANSVKRFVCQRCGLKREQLFFNCPRCYSWHSISFRTQLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKA8</accession>
    <name>D6SKA8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG domain protein DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869430.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3775"/>
    <dbReference type="EnsemblBacteria" id="EFI36311">
        <property type="protein sequence ID" value="EFI36311"/>
        <property type="gene ID" value="Dthio_PD3775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1944332at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="8994" checksum="A1E9C2B5EAA2EF5F" modified="2010-08-10" version="1">MSTLSIRLPDSLHERLKQMAEKEGVSMNQFIALALSEKISALHTLDYLKERAARGERREFEAILSRVPDVEPEEQDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKI4</accession>
    <name>D6SKI4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868329.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2602"/>
    <dbReference type="EnsemblBacteria" id="EFI35195">
        <property type="protein sequence ID" value="EFI35195"/>
        <property type="gene ID" value="Dthio_PD2602"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="147" mass="16755" checksum="A8C9D1116A4E5768" modified="2010-08-10" version="1">MKTVYLDVCALCRPYDDQAYARIHLETTAVRLILRAVEKGVYKMVYSPIHEMEISAIADNVEREDLLFLIDKIATRMEKAITHTRKRAEYLVSSGFGVADAAHLAYAERAQAFFISCDDKLVKKCTKSDIKIWAGSPIMFCEKEDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKL6</accession>
    <name>D6SKL6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868361.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2636"/>
    <dbReference type="EnsemblBacteria" id="EFI35227">
        <property type="protein sequence ID" value="EFI35227"/>
        <property type="gene ID" value="Dthio_PD2636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="87" mass="9513" checksum="8985F42314DA5691" modified="2010-08-10" version="1">MNNKETIKAPANANAPAGAKRKWARILVTSSLLLILGIGVAYLHSLPVVQEVKQAFRESGIDVSAFTYSDVEEYRDVKSGLRADPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKN5</accession>
    <name>D6SKN5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868379.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2657"/>
    <dbReference type="EnsemblBacteria" id="EFI35246">
        <property type="protein sequence ID" value="EFI35246"/>
        <property type="gene ID" value="Dthio_PD2657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="35532" checksum="5C96B46CF23EE273" modified="2010-08-10" version="1">MSMLYRSIQKLRRQDEHDIPVPSFVFKYSAGSSRKRYMRAGLISLVMLAVVTIPVLIFQSRLDVYLQSPESSEQYSVAGYEMTNPQTTRQEQTVDDSAGSEATVSEEEILVAGEDGSAMSVDTAGADEVKRQETSEASETGVAEDIVRDKLAGHASVQQESSYVKQGLDPGPPEPADLPQGYSQVRLDRDLQEHFTRQAQRNRTAMSLNRDMNAAFAAGDYDDVHEYMVRLRDILPGASPLVLKWEGILAMQDNDYEKARRKFQAVLSQNPEDSSARANLALAMLKLDRTDQARKILAELRAKSPDNPMIETLTRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKS6</accession>
    <name>D6SKS6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868419.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2701"/>
    <dbReference type="EnsemblBacteria" id="EFI35287">
        <property type="protein sequence ID" value="EFI35287"/>
        <property type="gene ID" value="Dthio_PD2701"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030VG5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2073271at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034756">
        <property type="entry name" value="T2SSM_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10741">
        <property type="entry name" value="T2SSM_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="199" mass="22885" checksum="9E65BDC9F512FD98" modified="2010-08-10" version="1">MKSWSKELINFLRDISVRGQPGSRAVLVIIMLVLMFLAGGRYLVQVYQDRATSLQDRIQSREMHYFNLTRLVAGGEHNRREFEMLQVFFNEELDPRFIQAPTAALAEARLQDLVSDMAGASGLEIMSIRMLPRTDDGVVSEMALGISARGEIDSIKDFLWRISSHEQFVFARRVEISIINPRERRHFNLDCQLAAWSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKT1</accession>
    <name>D6SKT1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868424.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2706"/>
    <dbReference type="EnsemblBacteria" id="EFI35292">
        <property type="protein sequence ID" value="EFI35292"/>
        <property type="gene ID" value="Dthio_PD2706"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="5"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="359" mass="39436" checksum="FB40AA459FF51559" modified="2010-08-10" version="1">MQRILITGGAGYIGSHAAVVMLEAGHEIIVLDNLCNSSQESLRRVELITGHRPQFVYGDIRDAEMLKRIFAAQKIDSVMHFAGLKAVSESLSCPLEYYDNNVGGTVTLCRVMAESGVHCLVFSSSATVYGVPPSVPIKEDFPAGEPANPYGRSKLMVEKVLTDLAESDPRWSVALLRYFNPVGAHPSALLGEDPDGIPNNLVPFISQVAVGRLPKLSIFGNDYPTRDGTGVRDYIHVLDLAKGHLAALMAMSGKSGVFTWNLGTGRGYTVLETLRAFEKAAGKAVPYEIVHRRPGDIAECWADPEKAQRDLDWKADYGLEEMMQDVWRWQSMNPYGYHAKRVASQAKRVNRSLTVPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKT2</accession>
    <name>D6SKT2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868425.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35293">
        <property type="protein sequence ID" value="EFI35293"/>
        <property type="gene ID" value="Dthio_PD2707"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZEZA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2168318at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="132" mass="14172" checksum="8C52373F26ECCD3E" modified="2010-08-10" version="1">MANYREGGFSGKAGLSLLEVMVVLIIMSLGMGLYLGINYRQQESLEVRAFASELGRFMGAAGSSAVVNATDNACVYVKADREVVENLKGRSITVPDGARIVLPEDPGAEEFVLAFFYADGSMGVADFFFGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKW7</accession>
    <name>D6SKW7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35328">
        <property type="protein sequence ID" value="EFI35328"/>
        <property type="gene ID" value="Dthio_PD2743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="10162" checksum="D22BB828A8BBDF9C" modified="2010-08-10" version="1">MKTSLDILCTAMDITGFQFSDLIIIYFIFWGVIQHTCLNLRIFQKFSNFFRFYMDYFFRKDYKYKKIGANFGPGSMFLTMQCLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKX6</accession>
    <name>D6SKX6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoenolpyruvate synthase</fullName>
            <ecNumber evidence="6">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD2752</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868469.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2752"/>
    <dbReference type="EnsemblBacteria" id="EFI35337">
        <property type="protein sequence ID" value="EFI35337"/>
        <property type="gene ID" value="Dthio_PD2752"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="53"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="503"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="850"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1203" mass="135005" checksum="F69AF2344B881805" modified="2010-08-10" version="1">MAKTGKEQKPGEEAQESKQEAKASKQKSRFDSLKSKLVLKASEIMEMGVEAELLVGGKNFNTAIINTIENIRAPQFRAISATAFHKLLDETKVNAAAIRASVDKEYDVIDWKDQAINDDPDFLKKLVRKLAVQVKRTPQKKDSTFIRLRTFINNVVEGFAVSPEGIDQLRKRSVLVQTAILSVDLPKEVEEAVRQAYTGICKEVGQDNVPVAVRSSAAGEDSRKKAFAGLQDTYLNIVSESSAVEAYHWDCASAYNLRSMTYRREAILDAVAKAESTGDDSIASKAKEEWSIENTSLSVCIMRMINPVISGTAFSADTATGCQGTDRKDLVSIDASYGLGEAVVSGMVTPDKFYVFQRDDGEEVVIRHMGFKDKKIVYDETGVGTVVQKVPEDLVTRWSLSLAQAEIVAKGVRAISKAYEGMIMDTEFCIDAWDRLWFVQARPETRWNEELEKHPNTIFMRRMEANKNAIANAEIILEGNGASRGAGQGTVKFLRSALELNKINKGDILAAERTDPDMVPGMRVASGILADAGGDTSHAAITSRELGIPAIIGIKRLEALRALDGQEVTVDGSRGLVYRGLVPLEEVGGEIDVGKLPATKTKVGLILADVGQALFLSRLRRMPDFEVGLLRAEFMLANIGVHPQALDAYDKGYLDSVVNKKFKEMENELTKVVRDQLTAGLVSLDLNLRRYVGIISGLEERMSQMTDQKGAKGTDEVLAMHRQLRELDKKLDEHIDLATKRLEVLKTSLDLKEHIAIIMGYADQLMLLVGDDPETVQKKEELEEDISRIEKRVKHDPVVQEHLKNIQDLRTDVAQKVGLKNEMDTVRDLPQNIHDHITSRGFRTGKELYVQTLSQGLALFAMAFYGREIIYRTTDYKTNEYRNLMGGMLFEHYEDNPMLGYRGVSRDIHDWELEAFKLARGAFGGSNLQLMLPFVRTFEEARSMKRYLSDVHKLRSGEDGLKIIQMSEIPSNAIIAKEFIKEFDGFSIGSNDMTQLVLGTDRDNSRLGHIYDEEDPAVVWSILVTIFTGQKFGKKVGFCGQGVSNSKIIRGLVCISGIISASVVPDTYAQTKEEFAKTEKENIKLKDMGAWLQKQHLERLYELLKENNYEHILKKYSSSKDLMEWYEGEAARLHEQLYSHLGSRKEDFYRQELYKFRNIFHKPVIYANWDWQVTIDDALHQAGFATYEEQEQAMAQVSQKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKX9</accession>
    <name>D6SKX9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868472.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2755"/>
    <dbReference type="EnsemblBacteria" id="EFI35340">
        <property type="protein sequence ID" value="EFI35340"/>
        <property type="gene ID" value="Dthio_PD2755"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="14824" checksum="C71489BFF557ACDB" modified="2010-08-10" version="1">MRTLVVEDDITSRMILVKILSHYSQCDTAENGHEALDLFAGAIKQGQPYDMVFMDIMMPVMDGQSALKKIREIESEQQVPIGQEVKAVMTTALSDTKNVTTAFFQGQADAYLSKPISREKVEKALQEIGVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKY9</accession>
    <name>D6SKY9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ORF">Dthio_PD2765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868482.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2765"/>
    <dbReference type="EnsemblBacteria" id="EFI35350">
        <property type="protein sequence ID" value="EFI35350"/>
        <property type="gene ID" value="Dthio_PD2765"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1854712at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="208" mass="23057" checksum="1024CE30ED209A9B" modified="2010-08-10" version="1">MNREFKIKICGLTDPEDLRLCQELRIDFTGFIFHPGSPRYVSPEKVGEWSKENELRVGVFVDATVREVLDATSRAGLDMVQLHGGQDPGFCRELGADMVIRTFWPERFQSSSAFEEELQKFTKACRYFLLDAGRSMGGHGRSIACSWLEGVNSPVPFLMAGGLGPDNLDPVLKTQAAGVDLNSGVEKAPGEKDHEKIKKAVNKLRGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKZ3</accession>
    <name>D6SKZ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868486.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2769"/>
    <dbReference type="EnsemblBacteria" id="EFI35354">
        <property type="protein sequence ID" value="EFI35354"/>
        <property type="gene ID" value="Dthio_PD2769"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="190"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="469" mass="52431" checksum="E4266B3BABBA3108" modified="2010-08-10" version="1">MINLQQKATCLPADTQTPVSLYLSLIGKEKGIMLESSEVDGRLGRYSLLAWDFRLQLSCSEGKLRVKTLDDRLDGLKEMQGMDFIQGVRSVLAELKVQPDPAFQLPPVTRAVYGYLGFGLGGLLEPRLAEVLPPEEAEAQLVLPGRILLFDHLHHNCYYICLDKEIALPKPKPCKARSEFKVGSVSTTPSQEEYQARVSDIKELIRQGEAIQVVLSTRFSADFRGDPFLVYRHLRRINPSPYTFYLNMEDITLMGSSPELMVKCGQDVLQLRPIAGTRHRAESEKEDERLAEDLLSDEKERAEHVMLVDLGRNDLGRMAVGGSVEVDKFMRVERFSHVMHMTSYLSARLKEGLDALEVIRASFPAGTVSGAPKIRAMEIIGEHEPAPRGPYAGAIGWIGLDKDSVNLDTGITIRSLWIRDGKIHWQAGAGVVFDSVPEKEWEECQNKAMAIRKALTFTGGPDDFAHRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKZ6</accession>
    <name>D6SKZ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.51</ecNumber>
            <ecNumber evidence="7">5.4.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Dthio_PD2772</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="8"/>
    <dbReference type="EC" id="5.4.99.5" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868489.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2772"/>
    <dbReference type="EnsemblBacteria" id="EFI35357">
        <property type="protein sequence ID" value="EFI35357"/>
        <property type="gene ID" value="Dthio_PD2772"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="21">
        <location>
            <begin position="91"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="22">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="19">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EFI35357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="362" mass="40778" checksum="7FE562FFE151E6CA" modified="2010-08-10" version="1">MDQETNLKRIRSEISRLDQELLQILNRRAGLSLEVGSIKSQSKDNVFKPFREKEVLNGLAQKNPGPLPDEHLRSIYREILSSSRSLQQPQKVVYLGPEGTFSYFAGVEYLGHSAKFTPKNSLEDVFRAVDTREAELGIIPLENSMQGSVGQSLDMFLKFEVFIHAEVFFRISHFLLSRETEMGAIKKIYSHPLALQQCSTWLRANLPGVEVIPDESTARAASRASTEPGTAAVGHQKLTKFYELNVLGNSIEDIPDNWTRFLVISAHPPEAGNREKTSLLFSVLDRPGSLVSALEVLSRKGINMRKLESRPLRAEKWRYVFFADVECDLTAGDYASVLKDLEDNCYYMRVLGSYPHGPQILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL10</accession>
    <name>D6SL10_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868503.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35371">
        <property type="protein sequence ID" value="EFI35371"/>
        <property type="gene ID" value="Dthio_PD2786"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZF74">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1670002at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="18555" checksum="C891967C525E1FFB" modified="2010-08-10" version="1">MNALPNIVDSETGQGLPRYDLRVENHGPSDLEFEIWQIPYNGTPDVKKPLRISGLRGRNLALIEHRVLRLLAKAGIHLGGLNIQDQARYALNEDQALNLGLLFRTLAPMRNRENMPMVADGIEAMGKEEAAYWLGMAMHRKYPRRVLMALRFLLIDPKARMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL27</accession>
    <name>D6SL27_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ORF">Dthio_PD2804</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868520.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2804"/>
    <dbReference type="EnsemblBacteria" id="EFI35388">
        <property type="protein sequence ID" value="EFI35388"/>
        <property type="gene ID" value="Dthio_PD2804"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1265792at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="261"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="377"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="451" mass="49433" checksum="9E70D9A4ABA17F12" modified="2010-08-10" version="1">MRKKLFGTDGLRGQANIFPMLPEIVLRLGLAAGQYFRNGHRRHRVLIGKDTRLSGYVFENALTSGFCASGMDVFLVGPMPTPAISFLTKNMRADLGVVISASHNPFMDNGIKFFDHKGFKLSDQVEEDISELVLSPDVNWKHPQPEAIGRARKIVDSPGRYIVHLKNSLPNTMSLQGMKVVIDCAHGATYRVAPLIFEELGAKVIMAGTEPDGVNINKKCGSLYPEVAASMVLEHGADLGLTLDGDGDRLIAIDENGVILDGDQIMAICAMDLMERDALPGNLLVSTVMSNMALEVFMQEHGGRLLRTKVGDRYVVEAMRKEGAVLGGEQSGHLIFLDYATTGDGILAGIKLLKIMLQKNRPLSELSRLLTPFPQRLINVHVERKMPFEEVQQVQEAVKDAEAQLGSKGRVLLRYSGTESVARVMVEGQDDTLVEDMAIKLARAVEEGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL61</accession>
    <name>D6SL61_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868554.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2842"/>
    <dbReference type="EnsemblBacteria" id="EFI35422">
        <property type="protein sequence ID" value="EFI35422"/>
        <property type="gene ID" value="Dthio_PD2842"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="141" mass="15942" checksum="F08358F48D321458" modified="2010-08-10" version="1">MKDKTFLDTNIFVYAIDSSGREKAKSQKARKVINEYVANMNGVISTQVMQEFFVVATCKITKKLSVDQALEYMRCISVLEIVYPDENMVFAAARKVKKYQMSFWDAMIIQSAQVSGCYFLLSEDLQHGSEVGGVKIINPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLF1</accession>
    <name>D6SLF1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868644.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35512">
        <property type="protein sequence ID" value="EFI35512"/>
        <property type="gene ID" value="Dthio_PD2936"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="311" mass="34671" checksum="690067D738CB6A14" modified="2010-08-10" version="1">MQPGYLQALETGELKRRIDKAGQWSTRCCLCPRNCGVNRLEGELGFCRTGPLAQVAAFNLHFGEEAPLVGENGSGTVFFGHCNLGCVFCQNHDISDNQSTHQEVHPNQLAWIFMQLQKQGAHNINLVTPSHVVLQVLQALELAAGDGLNIPLVYNTSSYDEVHTLKLLEGIVDIYLADSKFFYSEQARKYADAPDYPQKAKEAILEMHRQVGGLETDDQGIARRGLMIRHLVMPDNLAGSDEWLQFFAENLSKDTFLNIMGQYRPAGMAHNYPELLGRVSGNQVETLNKKARKLGLTNLDQRSSGIFRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLF7</accession>
    <name>D6SLF7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldh</name>
        <name evidence="12" type="ORF">Dthio_PD2942</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868650.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2942"/>
    <dbReference type="EnsemblBacteria" id="EFI35518">
        <property type="protein sequence ID" value="EFI35518"/>
        <property type="gene ID" value="Dthio_PD2942"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="11">
        <location>
            <begin position="149"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="316" mass="34613" checksum="D1F0696D7A056866" modified="2010-08-10" version="1">MQENFLHKKVTIIGTGMVGMSYAYALTIKGFVRELGLINRTPERAQGEAMDLCHCLPFVEPMDIKAGGYEMCRDAQIVVITAGAAQREGETRLDLLHKNAGIIQDIVPRVLEQNPNPILLIASNPVDVLTYVALKVSGLPSSRVIGSGTVLDTMRFRYLISQYYNVDARNVHGYILGEHGDSEVPVWSRVNIAGIPLSEYCMMCGELVDSQKKEIESDVRNAAYHVIQKKDSTYYAIGLALVRITQAILMNQQSVLTVGTLVNGEYGIKDVCLSLPCVVGSNGISQVLANPMQQNEVEALQNSAAVLRKALDSIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLF9</accession>
    <name>D6SLF9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868652.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2944"/>
    <dbReference type="EnsemblBacteria" id="EFI35520">
        <property type="protein sequence ID" value="EFI35520"/>
        <property type="gene ID" value="Dthio_PD2944"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728429at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041215">
        <property type="entry name" value="FlgO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17680">
        <property type="entry name" value="FlgO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlgO" evidence="1">
        <location>
            <begin position="40"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="272" mass="30526" checksum="C458E3A975F7781D" modified="2010-08-10" version="1">MKRLAIFIAAMLFFMAGINTVYAWQPQLYHAKEGLPGIAYQAADMLEYNITRDLSRTLPIMTTSFVDVSDLDQTSVLGRQMGELMGSRLSQHGYNVVEMKLRQDSMRMARGSGEFALSRDMDHLKDSWGAQAILTGTYHVQGDRAMVTTKLVKTTDNAVIASHDFSFRLDGDLKAMTEAETVPSEEEVEEKKVNGKGPLSEGAILLNPSRSTDAKLIQKRLADLGLYLDRIDGIWGRNSKRALEMFKSKNQLPDPQKWDAQTQIRLFRSTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLS6</accession>
    <name>D6SLS6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868766.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3066"/>
    <dbReference type="EnsemblBacteria" id="EFI35637">
        <property type="protein sequence ID" value="EFI35637"/>
        <property type="gene ID" value="Dthio_PD3066"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="108" mass="12284" checksum="5F539435BFC5749B" modified="2010-08-10" version="1">MTDSKNNQPRESLQNAAQLAKALGDANRLRILRCLGSERQSVSALVEQLDLSQPLVSHHLRELKRLLLVIVERQGPFVYYSLNDPRVLDVLDQLEQLAQLVLDKRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLW9</accession>
    <name>D6SLW9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35680">
        <property type="protein sequence ID" value="EFI35680"/>
        <property type="gene ID" value="Dthio_PD3109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="45" mass="5064" checksum="ECBB133B68587A5D" modified="2010-08-10" version="1">MADVKSSVPKVEVQVTIQPAGVSRPQELNSYKCKRITKFLITLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLX4</accession>
    <name>D6SLX4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868814.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3114"/>
    <dbReference type="EnsemblBacteria" id="EFI35685">
        <property type="protein sequence ID" value="EFI35685"/>
        <property type="gene ID" value="Dthio_PD3114"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030I61">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382399at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="175" mass="20079" checksum="12BBE6349D0AFD57" modified="2010-08-10" version="1">MSSDSVFQEVKDFYRIIPLQSLRRTPGVFFDNVPMEFLPRIDAIDRVLHQGGAVSPGPVGDVQRPWYMHPHQDDNLIVLYGVRDVDIYINGHGMTSFRVTPHEIIQNGEVLYDGPAMLVWPRYVFHRITSGEEGSASLNFAVHYQGLDMRTNFNIYDLDTETGSFEVIREGFRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLY5</accession>
    <name>D6SLY5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNP-1 like RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868825.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3125"/>
    <dbReference type="EnsemblBacteria" id="EFI35696">
        <property type="protein sequence ID" value="EFI35696"/>
        <property type="gene ID" value="Dthio_PD3125"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029304at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9333" checksum="2EA6DED5230ABA8A" modified="2010-08-10" version="1">MTNLYVGNLPWSTTEAQLRDSFAEFGEVSSAKIIEDRETGRSRGFGFVEMENGADEAIEALNGKDYGGRSIKVNVAKPKRESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLZ5</accession>
    <name>D6SLZ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="7" type="ORF">Dthio_PD3135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3135"/>
    <dbReference type="EnsemblBacteria" id="EFI35706">
        <property type="protein sequence ID" value="EFI35706"/>
        <property type="gene ID" value="Dthio_PD3135"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCRF" evidence="6">
        <location>
            <begin position="86"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="368" mass="42160" checksum="75A0755E6CDB9893" modified="2010-08-10" version="1">MIQQLSDIKARSDQVLQRFSSFWGRLDLESQKQRLEEIEHELSRPGAWDSPEKLTPILKEKSGLEESVSKYEQLHSLQEEVREWLEFADNDQSGEVLQALEDSLETLSRQLEKVELEALLSGKDDNNPAIVSIHPGAGGTEAQDWVEMLLRMYTRWAESKGFKLDYLDYLPGDEAGVKSVTLQVTGEYAYGLLKSERGIHRLIRISPFDASGRRHTSFASVDVYPQVSDDINIEVKEEDMRVDVFKASGPGGQHVNKTSSAIRITHMPTGIVVQCQSERSQRRNRDAALKILKAKLYDEEMKKLEDERQEKYAAKDSIAWGSQIRTYTLHSYRLVKDHRNNTEIYDVDSVLDGNIDTLIRNYLLYRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM60</accession>
    <name>D6SM60_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868900.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3203"/>
    <dbReference type="EnsemblBacteria" id="EFI35771">
        <property type="protein sequence ID" value="EFI35771"/>
        <property type="gene ID" value="Dthio_PD3203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10613" checksum="FA0E57F0074C1E47" modified="2010-08-10" version="1">MIISFKCEYTEALSQGSRVKKFSNIAKIARRKIRQLQIANRLDDLKVPPGNRLEALKGDRAGQYSIRINDKFRICFNWTNAGAENVEIVDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMF3</accession>
    <name>D6SMF3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK domain protein ATP-grasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868993.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3303"/>
    <dbReference type="EnsemblBacteria" id="EFI35864">
        <property type="protein sequence ID" value="EFI35864"/>
        <property type="gene ID" value="Dthio_PD3303"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="83"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="263" mass="29636" checksum="FBCB14D1CBE7C2F4" modified="2010-08-10" version="1">MEPSSTQPRIALGSQLISCPDVLTLGVLPNLEDYPAWKLDMILQAEKIYFPTSLYADLFQVMGKKMFPSVNTYRFLGDKIKQTLLFQLQNLPAPRTRFYFGPRQQQFITRDFSFPFIAKKARASSMGDGVWLIHDQNELDSYLSQNQPAYIQEFLDVDDDYRVVVVGDEVAHAYRRIPARGSFKANISQGGTVCLENIPGDVLELGLRAAQACGFDLAGIDICQSREKLYILEANMKFGTRGFHCAGLSYRAILNKKVSEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMF9</accession>
    <name>D6SMF9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868999.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3309"/>
    <dbReference type="EnsemblBacteria" id="EFI35870">
        <property type="protein sequence ID" value="EFI35870"/>
        <property type="gene ID" value="Dthio_PD3309"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="194" mass="22480" checksum="C5316FB0B89BB995" modified="2010-08-10" version="1">MAKNKKHKILSTATQLFANQGFDNTTTLQIAKEAGVTEPLLYYHFKGKEEIFTEIIRSIFQDYEKMLEELPRETETEFEKINNLIRLHIHMAENRPNEGRLILANCPSKLKNESHTCQKIVDRQQEIIVDYLRECLEKGNASGEFDAQPVDHLVVVMLCLINGILRKKLLGKKEKISYEYTAIDFCRKAIVKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMI7</accession>
    <name>D6SMI7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3337"/>
    <dbReference type="EnsemblBacteria" id="EFI35898">
        <property type="protein sequence ID" value="EFI35898"/>
        <property type="gene ID" value="Dthio_PD3337"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="231"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="369" mass="42242" checksum="D6A3CBD76E005768" modified="2010-08-10" version="1">MQHKLSLAYFLPVQDPGHVRRAACLMNSIHAQWPFVHFEVFSGVREDVLKNHLQAAHACHNRYPGTALVHDRPRQDNPEEKAEFLQRCLSFGQEQVGEYSQLLSEAGCCLAISDTSPLAIAAAGKAGIASVLVEDYFWTEVYKGLFSNEPFLKEYADMLGKYLHQADLRIDLPAAEDSHAQHIPEHQGYGDAARAICHYLVQEQEILEVVDREGCVLGAAPRKRVHGNNSLLHRVVHVLVFDDQDRLLLQKRSLNKRVAPGRWDTSVGGHVDCGESIETAMYREMQEELGIRPRDVQFAYKYIHSNDFESELVYTYTCRYDGQVEFNPEEIDAVKFWKTEEIEENLGNGTLSDNFEDEFRLYRQWMGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMQ0</accession>
    <name>D6SMQ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869089.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3403"/>
    <dbReference type="EnsemblBacteria" id="EFI35961">
        <property type="protein sequence ID" value="EFI35961"/>
        <property type="gene ID" value="Dthio_PD3403"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14675" checksum="92823FFC55CFF857" modified="2010-08-10" version="1">MSSNKNIRILVVDDFSTMRRIIKNILRQLGYNNIVEADDGTTAWEILNKDKIDFIVSDWNMPKMTGIELLRKVRSSEEFSDLPFLMVTAEAQQENIIEAVQAKVSNYIVKPFTADTMSQKIEKIFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMR5</accession>
    <name>D6SMR5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869104.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3418"/>
    <dbReference type="EnsemblBacteria" id="EFI35976">
        <property type="protein sequence ID" value="EFI35976"/>
        <property type="gene ID" value="Dthio_PD3418"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="210" mass="23120" checksum="211C7360BFDC6B79" modified="2010-08-10" version="1">MLEIKTFPLGVLQTNCYVLHSQQEALVMDPGGDPQRIVDYLRDNGLSLAMILNTHLHFDHIQGNAALAESSGAKIFAPEEDRFLLDTEVGGGGFMDFPETPGFDFEDLKEGKQELLGHECTVLSTPGHTPGSLSFYFPDLKAVFVGDLLFQRAVGRTDFPGGSMEVLKKSAREKIFTLPGDTVIYSGHGPQSTVMDEKQNNPFFQNSSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMR7</accession>
    <name>D6SMR7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase and serine/threonine protein kinase with TPR repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869106.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3420"/>
    <dbReference type="EnsemblBacteria" id="EFI35978">
        <property type="protein sequence ID" value="EFI35978"/>
        <property type="gene ID" value="Dthio_PD3420"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="352150at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="630"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="795" mass="89755" checksum="6AA84E60E6AD329D" modified="2010-08-10" version="1">MKPRLDKSDLILFESVLKDSLSTVISFSAYSLYFPQEIPSIMYHDRDIVPVVEKDRVLLPLMYDGRFLGIFMARGTDPERMQALALDLPGIISLCLDKVLLQKQCITDSITGLYNQEKFHQLLEKAVEDIQASLTLGPAASMDSGLDRYSATFCVMLINPDRFKRINETFGYAFGDQVLYELAEHVRKELPEQAVSARLCNDTLAVFWPQAPAARCRELSENLRSRISSQVFEYPVSGEKISLSAGIGWSLFPQDIKGPQFQKSPFELAHLVCRKAGEALKVSKENHNSKAFAFSQILQHGGVVLEVLPMNRLVLNLGKNMDALEGQKFMVWSQKFNGQSQSIKKAGHSSGTYPAIHKGEIAIQEVQEEVSIAEILYLNDPAWKIESGDKLSLLAEKESLLEKQDMLNKDIQPRDLFTGLYSYRDFLSLWTRARIQDEYFCMAMLKLEYPGKDTQSKGIDLENLVQEIIRIVDRKFSRQPLSGRYSSTCMVFYFSGQNAQSLKEPWFYLLEEIKSSLHIPASLALADYPCLSYSKTDTLENCRKALEHARLTTPPRMACFDSLTLTVSADSLFSQGDTFAALEEYKQALAADENNLLARNSLAICYARLGRLELARQHFQEITDKDSENLMAWYNLGCVCLKQGDSLEAANLFAKCLEIDSSHAFSLLRLGQLAENSADFEKAARCYQEAGQTRDGAGLAPRHLARLAWKQDQKEQSREFLHQALLQDPRDAFSLNLMARMYLQSGDDPEIAESLARQSVALRPDVSEFWLDLADIFKARDKSEQEAQARARAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMS3</accession>
    <name>D6SMS3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869112.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3426"/>
    <dbReference type="EnsemblBacteria" id="EFI35984">
        <property type="protein sequence ID" value="EFI35984"/>
        <property type="gene ID" value="Dthio_PD3426"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1788557at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="12429" checksum="67DD070776A58969" modified="2010-08-10" version="1">MEELKKFKNLPIDWDVEPADAVAMHLEWGNTGYSGKHHDSDSETYFFCIDSWQEPYILRLQKMTKDGSESLYEMELPREFWDCCRARGVHGLPPEVKEWLQKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMT3</accession>
    <name>D6SMT3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferric uptake regulation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur</name>
        <name evidence="4" type="ORF">Dthio_PD3436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869122.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3436"/>
    <dbReference type="EnsemblBacteria" id="EFI35994">
        <property type="protein sequence ID" value="EFI35994"/>
        <property type="gene ID" value="Dthio_PD3436"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="123" mass="13942" checksum="8CC1C7F64C7B905B" modified="2010-08-10" version="1">MKHKTQQRKALMECLHEARGPLSPAEILWFSREKVPSLGIATVYRNLKLLVEEGFVAELQVPGQGSYYEPADMDHHHHFQCRNCKQLFCIPGCPPGITSLAPEGFKLDGHEIFLYGRCSECTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMT4</accession>
    <name>D6SMT4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869123.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3437"/>
    <dbReference type="EnsemblBacteria" id="EFI35995">
        <property type="protein sequence ID" value="EFI35995"/>
        <property type="gene ID" value="Dthio_PD3437"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="334" mass="37586" checksum="0147734090605417" modified="2010-08-10" version="1">MPEKKSPVKAGLSAWALITTVFLMLLWPAMAPASDKDSLDIMVSIAPQKYFVDRIGGELTDTTVLLPAGASPHTFEPKPSQIRKLGRADLYMAIGVEYENALLPRIKSTHPDLEIVRLDRGIEKISMLQDCDHDHDHGHDHDHEHNHNHDHGHDHGHDNGHDHHHDHNGHDGLDPHVWLSPDLAMIIADNVYRALSEAMPGAEAEFRDNYLAFIRELLELDQEIKSVFNDVPPGSRFMVFHPAWGYFARAYGLVQVPVEVEGREPRSADLKELIDTARDEGIKVVFVSPQFSKRSAETIADSINGETVSIDPLAENWKENMLTVAEKFRKAMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN13</accession>
    <name>D6SN13_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869202.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3521"/>
    <dbReference type="EnsemblBacteria" id="EFI36074">
        <property type="protein sequence ID" value="EFI36074"/>
        <property type="gene ID" value="Dthio_PD3521"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZRV3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925819at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="75" mass="8463" checksum="3E7031109452099D" modified="2010-08-10" version="1">MKMEYDPVRDLLYMWFGTPGTKSAETKTIKPGLHADFDKEGKLLGIEVLDASEVLQHRVQFEFSLTSSSSKEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN14</accession>
    <name>D6SN14_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3522"/>
    <dbReference type="EnsemblBacteria" id="EFI36075">
        <property type="protein sequence ID" value="EFI36075"/>
        <property type="gene ID" value="Dthio_PD3522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7977" checksum="4748E404C3370619" modified="2010-08-10" version="1">MMLKWVPECLSPAFLKSAKQILEYESYWEDLYYQQKEVTVYYKQQEGNNLILLTVIARYGQNFFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN20</accession>
    <name>D6SN20_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869209.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3528"/>
    <dbReference type="EnsemblBacteria" id="EFI36081">
        <property type="protein sequence ID" value="EFI36081"/>
        <property type="gene ID" value="Dthio_PD3528"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1948244at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8864" checksum="15316DF299D13D82" modified="2010-08-10" version="1">MPLIKRFANCQVRINLKDHAPPHFHVLMRDGKEALIELSGLEILQGNVPRRELSEVLQWAASNRNMLMNKFEELQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN33</accession>
    <name>D6SN33_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869219.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3542"/>
    <dbReference type="EnsemblBacteria" id="EFI36094">
        <property type="protein sequence ID" value="EFI36094"/>
        <property type="gene ID" value="Dthio_PD3542"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZA9J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1313648at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="302" mass="35475" checksum="FFAAF7E537E2CDF5" modified="2010-08-10" version="1">MKIRYIKLGLNGEWEEECILKDQTLRLGYQSSKHQESLRGDWEAVRDYWLKVRDGNQRSASRDLNQIRDFYELKKTDIWVTFYSRKLYWCHAEEDVHELNDGTRIRRVIGSWSCKDKKGNLLTIENIDGRITKVQGYQGTICAVELPEYLLRKINGDVQPEIQATIDSLADLKQRVEELIKGLWWKDFELLVDLIFSQSGWQRVSVLGKDQKSLDLDLFSPVTQKRAFVQVKSSTNISDLQYYQEEFNKSDHDEMYFVYHTFTGDPEQLPNNNPKVSIWDVSRIADLVINAGLVRWLLTKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN41</accession>
    <name>D6SN41_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869227.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3550"/>
    <dbReference type="EnsemblBacteria" id="EFI36102">
        <property type="protein sequence ID" value="EFI36102"/>
        <property type="gene ID" value="Dthio_PD3550"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="897694at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="339" mass="38866" checksum="1D477DDF7FB5C45E" modified="2010-08-10" version="1">MLYKLRSTHGNFDRIDPVAFKDFSSFGSLEKDLEELIAESILDILFEDGGLMPIFQERQYQSEADIYALNKKGELIIFELKGGAAGEGAVYQALRYAQDAGQWTFSTLQQKFNQYSNSSSDLPLAHKEAFKLEQPLDAKELNKKQHLIIIGSAADDNLINAVDYWKHQGISIKFLPYRIYEINDEKYFEFFTLPYDRHINPGHEKGVLFDTNRSWDEDAIWYMMENNRVAAFGGAKRFVEYVYPGDIVFFSHRWTGLVAAGRVKKGSINSPDDATSYRDVEFITPVPKKGQTIKAMPFGMVSEITGMSFFWARTIKVPYLSKDEAENLAKELNTYLEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNI3</accession>
    <name>D6SNI3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Formate dehydrogenase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1660"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047111">
        <property type="term" value="F:formate dehydrogenase (cytochrome-c-553) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006443">
        <property type="entry name" value="Formate-DH-alph_fdnG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01553">
        <property type="entry name" value="formate-DH-alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0711">Selenium</keyword>
    <keyword evidence="10" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="10">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="999" mass="112240" checksum="9F66C7AF9D33D741" modified="2010-08-10" version="1">MKLGRREFIKLSATATAVTAFAGLGMNLQPTTAKAQLLKIHWAKETTSICCYCSVGCGVLVHTDKSSSGRCINIEGDPDHPINEGALCAKGAALYQVAENENRLTKVMYRAPYTDKFVEAPWGWALQRIAEKVKEARDETFVQKNDQGQVVNRTDGIAHVGSAEIENEENWYLQAMQRAMGLVYIEHQARIUHSATVAALAESFGRGAMTNHYNDLMNSDCILMMGANPAENHPISFKWVMKAKEKGGKILSVDPRYTRSSTKADLYVPMRSGTDIAILGGMIKYILDNNLYFEEYVKNYTNASFLVNPDYGFDNGLFTGWDADKEAYDKDTWTFQMDDDGIPKKDPTLQDPNCVFQLLKKHYERYTLDKASETAGSPKDKLEEFYKMYSETGAPDKAGTIMYAMGWTQHTVGAQIIRTMAMIQLLLGNVGVAGGGVNALRGTSNVQGSTDQALLFHIIPAYMPTPRANLATLDDYNDTTPTTEDPKSANWWQNRPKYIASLLKAMYPDKDPKDSYKWLPKLDEDQNASWLVLFDHMLQGKFKGFFVWGQNPAASGANSSKTREALGKLDWLVSVNVFDNETASFWKGPDVDPGRVKTEVFVLPPAVFCEKEGSVSNSGRWIQWRYQGPKPPGQCARDGDIMLELFTRIRDLYKKNGGVFADPILNLNEKDIAKEGKQFPERFDVQKVAKLMSGYDVNSGKQVANFTQLKDDGSTACGNWLHSGAWTEDGNMMARRDKDQTDMQANIGLFPNWSFAWPVNRRVLYNRASVDQDGQPYAPDKAVIKWEDGEWKGDVPDGGWPPAEKHPFIMRAEGYGQLFGPGLADGPFPEHYESMECPFEEHPYSDQLHSPTALYFEEELEKHAVCDPRYPFVGTSYRVCEHWQTGIMTRWVPWLLETMPQNFAEIDPELAKLREIESGDEVIVENLRGKIECIAIVTPRLQPLNIMGQTLHQVGTTWHFGWVHPKDGGDSANLLTPSVGDPNTFIPETKTFMVNIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNJ9</accession>
    <name>D6SNJ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34325">
        <property type="protein sequence ID" value="EFI34325"/>
        <property type="gene ID" value="Dthio_PD1676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="114" mass="12971" checksum="23B8EDBAC061AE19" modified="2010-08-10" version="1">MHLNHPLEPRNPGLPVNSLEHLESSLVLLENNPEHLESSLVLLENNPEHRVSNLGLLENSRAHRKLLKATRLLTPTTLPKGMNLLKDTNPRKSRNLVMNRHSDNFQILPQKFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNM7</accession>
    <name>D6SNM7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OsmC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1704"/>
    <dbReference type="EnsemblBacteria" id="EFI34353">
        <property type="protein sequence ID" value="EFI34353"/>
        <property type="gene ID" value="Dthio_PD1704"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="3">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="28464" checksum="6330F3E0AB24B317" modified="2010-08-10" version="1">MTQEKENISVDDITPDHMFDGGDLDCGSGLSLMIKENMLKVPVGGILELRSRDATVKDDLPPWCRLASHEYLGHKDDDGFVRYFVRRGRPESAGKEEVSEEEALEQDKQKAREYEWRVRTRSTGSQKSTVYCRNFSWNMGQPISFEEKDEHPCSVEALLGALGGALASGYATECSKEGIEVDDIEITVRGRLTNVLAHVGLEEGDPGFGEIEVKCYASSMDDEEKVRDAWGKTVKRSPLAATLAKGTELKIKLMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNP0</accession>
    <name>D6SNP0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterodisulfide reductase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869694.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1717"/>
    <dbReference type="EnsemblBacteria" id="EFI34366">
        <property type="protein sequence ID" value="EFI34366"/>
        <property type="gene ID" value="Dthio_PD1717"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1319322at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="171" mass="18660" checksum="DDCF21D633C804A7" modified="2010-08-10" version="1">MSEYIKLESDKISEGVKTIMDLGGHGLLRCVQCGACSAVCPGVKAGFPVLCRMLIKKILDGQLEEIIEDSSSWGCQACNRCTEVCPQGVRPQEVVFAFRRYQANDLAFSTSAITSQMNLHAYGHAVFTDARELRAKVGLPPEAPTSAYNEKAQKEIQTLLDNSPMGELGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNQ3</accession>
    <name>D6SNQ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1731"/>
    <dbReference type="EnsemblBacteria" id="EFI34379">
        <property type="protein sequence ID" value="EFI34379"/>
        <property type="gene ID" value="Dthio_PD1731"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033MUH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9659" checksum="24EA87D36F7D0915" modified="2010-08-10" version="1">MLSGLLIAEIYGVMQNQFVLCIENKDCDDLEKRKVYQVIPDESASLDGYLRVIDESGDDYLYPESFFVFVQLPQQGAEVFQVSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP18</accession>
    <name>D6SP18_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869816.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1853"/>
    <dbReference type="EnsemblBacteria" id="EFI34494">
        <property type="protein sequence ID" value="EFI34494"/>
        <property type="gene ID" value="Dthio_PD1853"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="13"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="260" mass="29359" checksum="A269A2681B2832DB" modified="2010-08-10" version="1">MKRTDLTFLFLPVWKRNLIVYRRTWKVNFMVPLLEPLFYLAAFGIGLSGLIGDVVYAGEKLSYIQFIAPALLATAIMFNAFFENTYASFVRMYYQKTFDAMLATPLSLEEVVTAEIVWGATKSMMAAVIILGVISVLGFAVYPWALVVIPLAFLGGMVFGSVGMFFTGITPSIDMFNLPFFLLVTPLFLFSGTFFPVASLPEWGQHLARISPLYHLVELTRLCTMGRMESNLLVSLFYLKGFAAVFYFLSIRSMRNRLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPJ0</accession>
    <name>D6SPJ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Na+/H+ antiporter MnhB subunit-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2038</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869986.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2038"/>
    <dbReference type="EnsemblBacteria" id="EFI34666">
        <property type="protein sequence ID" value="EFI34666"/>
        <property type="gene ID" value="Dthio_PD2038"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1836204at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="10">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="9">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="316" mass="33342" checksum="C7A878B825D8EF7F" modified="2010-08-10" version="1">MALFLDVLVAFALVATAWRIMRAPGHFQAVVLFITFGLLLSLAWARLNSPDIALAEAAVGAGLAGVLLLDTLRAVAQPGKVKTGAHFSWLLLPCLLLAGLLSLSIIHIEPDSQGLIRAVEAGMQATSLEYPVTAVLLDFRGYDTWLELGVLLAAVMGLLCVRRKESIRSPLLPAPAEPVGRWLISILLPLILLVGGFLLWLGAFAPGGAFQAGVVWAAGGVLLWQAGHPSLGALPVSLWRISAVLGFALFWLLAAAALFRNEPMLTHPQAKAWILAVEYAAALSIAVCLTSLTIGGQKSGDKGQGAGVRGQKSEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPP2</accession>
    <name>D6SPP2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2091"/>
    <dbReference type="EnsemblBacteria" id="EFI34718">
        <property type="protein sequence ID" value="EFI34718"/>
        <property type="gene ID" value="Dthio_PD2091"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031DZ3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025460">
        <property type="entry name" value="DUF4280"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14107">
        <property type="entry name" value="DUF4280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="13072" checksum="5AA83964B02A2ED3" modified="2010-08-10" version="1">MAFLVTSGALMLCTFGTIPSSMLVLPVNRVFASMPAATIMDYVPFINIPPFGLCTTPSNPAVASATAAALGVLTPMPCIPVTVAPWITGKPTVLIGSMPALTDSSTLICSWGGVISIKYAGQVKVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPP8</accession>
    <name>D6SPP8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870042.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2097"/>
    <dbReference type="EnsemblBacteria" id="EFI34724">
        <property type="protein sequence ID" value="EFI34724"/>
        <property type="gene ID" value="Dthio_PD2097"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="389978at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010272">
        <property type="entry name" value="T6SS_TssF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35370">
        <property type="entry name" value="PTHR35370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05947">
        <property type="entry name" value="T6SS_TssF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="541" mass="61307" checksum="B69AA6B29A85BEC8" modified="2010-08-10" version="1">MRIDEKIHKAFLEEISALENFRVNYASIHPSAPLDRDDPDVRRLMETMAFFNARSRLAAEKHILALRRRLFRQYFDYLLSPMPVAGLMQAQPTAQLADTLSLPRGTQFLAVPPDGRQAFFSTLTDLSLMPVSLSGLTTLYRPDRGTRVLLRLGVPYPRSDSIGTLRIHINYLNDFKDSLRVLHALSKHLVHSSVVYDEAVNETTSGRPCSVTFGLEQQNPGEDQADHFSHPIEKERLLIHFPQQQLFMNIKVAPSPRPWSTATLCLDLDENWPANLNLNRGMFQLHVVPVVNLKRDLAQPIICQGTKEQHGIFHHMPEAGFCLHSVRGVYESGPNGFIPLRSGTFMGGSGSYEVDFSSQNDTQGVWLLLNYPEAFEDKKQISVDALWHQPWLSEVIDHRLRIFPFSRMTTGVKWEWAAFPVPHRENPYLKHYDDFSQLITLKNKTMYNMEDVKLLLNAAGVSGSEAYHEAAQQLKEVFCLPSPGKASHKNGMVKQIYQFSFTDDAQLHEALIQNFAGLAQKILDVWIADTAVEVETTTGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPR5</accession>
    <name>D6SPR5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Extracellular solute-binding protein family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2114"/>
    <dbReference type="EnsemblBacteria" id="EFI34741">
        <property type="protein sequence ID" value="EFI34741"/>
        <property type="gene ID" value="Dthio_PD2114"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="9">
        <location>
            <begin position="43"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="745" mass="84948" checksum="5BBDCF8869C5A779" modified="2010-08-10" version="1">MPALTINSAYRALQSCRLCFLICLFVVLSGILYPAFAQNQAHELRSGWYPDEPYQMQAGTGTAAEVTGLDIQIARELFEQTGHRVTFEPMSWAEILEGLKTGETDFLMGAYYEEAREEFAYFSKPYRTERNEIYYHKSIDKLSSLNSVQELLQFLQSEELRIAVIEGHAYGSEEFRKLMQDPPPNLELITSQGYEENLHLVVEGRVDLFVANPIIMDRLTARSQASGLVQKLGIKSQEIPVHILFSKKSISRGQLEEFNSILQDMQEQGRISTLHRDFVLPAYLSITTGQTWFAVLNLLGIAAFCTSGVLLARKERYNLFGALVLATLPAIGGGVLRDLFLGVDQVFVLETPAYFLVAIAIVLAGFAIIRYYDFIHDRSGTLAKKIDAFIENRLGSVFDRLFKFFDAWAVASFTVIGVGVALEMRAEPLWLWGPAMAVLTSSGGVILRDIVRADFNIEMLKQDTYAEISILGGIIYTCALMYTPYEISLGLIFYLTMFMVLLLFALRFFILWKGYMNPFQFGDIYTHPDTRLQQFREKEPHLWKVVSGYYTEDDESRAAPVHRSRLEEMHNRFLYLTGELKESLDQVAAEPLNEKTINNYRQCNARLEIAISLENNLYAFLEQKPGKGMQPSVDGSELQQLMHESLRTMIDTTAMAVETGDVMDFTMLEGLTSQYRQRFDHLRDKYRGRQKEHDDAHLKAVLQSTHKVERIIYLLSDYVKLRLDKKEIRAGSATNRKAQQAHVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPX4</accession>
    <name>D6SPX4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870116.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2181"/>
    <dbReference type="EnsemblBacteria" id="EFI34800">
        <property type="protein sequence ID" value="EFI34800"/>
        <property type="gene ID" value="Dthio_PD2181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="433" mass="47562" checksum="06393900D9B0588A" modified="2010-08-10" version="1">MVKKLYIFLLCILTLILTLNIVLGGMGGDGDTEDIDDIKTVKEAMESGIPLEEFDDLNFNSEEEYFHMVEHGLTGSPSEDTEITLADGRTAILKEGGVSIGSEKVNVRPDPPGIVLEDGTGISGEFDISDLVDGNIPAANELNFESSEGDSSSGQGIEGFSMDGPDYTIDYADYWETDSHKIVEGHGIQKKGGNIYVDEGHAIDSDDEFVNYADSYESSGDEFNIGEAKAVLLDGTLFTDIKDSYFKTKDGAITEASVTSSTDDNSFTLDGITVEMDENDTFNAKLDEETGKFDLSLDSEQGKIEATYPNVGCVEISPGSRFEYTGSDFDDFALFVPSYGGVYELCIRTLPEENYTSDCSRCGVKDFVNKTAEFNGIYQYEKPSVFEDDIFRNMIDASGNYSMEADNHKFNNTYIFRRSHGDAALEHKAPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPY2</accession>
    <name>D6SPY2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870124.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34808">
        <property type="protein sequence ID" value="EFI34808"/>
        <property type="gene ID" value="Dthio_PD2191"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2092914at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="18136" checksum="2C355FEA12A3F4A3" modified="2010-08-10" version="1">MKLKLNGWQRLWVVAAGIYFIVVCVVGAAMFPDGARLEAERAKVAIDLALRAQVDAARTLGNERAELDALSNLKRGAAEIRTEAYGDLSDAELIQRIRTTFGGKADFSTLDERIKRDAEHLRDDRTTFIFQAAAWWTIPVLALYILGSAIGWVIRGFRNKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ23</accession>
    <name>D6SQ23_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">engB</name>
        <name evidence="10" type="ORF">Dthio_PD2240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870163.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2240"/>
    <dbReference type="EnsemblBacteria" id="EFI34849">
        <property type="protein sequence ID" value="EFI34849"/>
        <property type="gene ID" value="Dthio_PD2240"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1746051at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="206" mass="23333" checksum="5A84C44E6F617CC8" modified="2010-08-10" version="1">MYLTLRLETTSYTKDQLRFPDLPQIALAGRSNVGKSSLINSLAGQKKLARISSTPGKTRSINFFLAPQENFYLVDLPGYGYARCSRVEREKWGELIQEYLQDNHHLAGVVLLLDSRISPQSSDLDLAHYVDSLQTRLLPVLTKADKCNQKQRQLALKRWQKLLERAHKPILFSARTRQGQQALLEAIKNLVQAGSSPVHPEKLQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ30</accession>
    <name>D6SQ30_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoVT/AbrB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870170.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2247"/>
    <dbReference type="EnsemblBacteria" id="EFI34856">
        <property type="protein sequence ID" value="EFI34856"/>
        <property type="gene ID" value="Dthio_PD2247"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11067" checksum="72512110E0F41173" modified="2010-08-10" version="1">MKKETRTARLFKNGSSQAVRLPAEFRFDGHEVYVTRDETTGDVVLSSSPGANTWEDFFDLIHSLDVPEDFMTERPMNILPQESGVFDDAVNLETDKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ36</accession>
    <name>D6SQ36_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA-ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870176.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2253"/>
    <dbReference type="EnsemblBacteria" id="EFI34862">
        <property type="protein sequence ID" value="EFI34862"/>
        <property type="gene ID" value="Dthio_PD2253"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191489at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="515" mass="59923" checksum="84736B23886BBFB8" modified="2010-08-10" version="1">MKKLPIGIQTFENLIQEGYYYVDKTGFVHEVTSQGKYYFLSRPRRFGKSLFLSTIKAAYQGKKDLFQGLYLEENWDWNQTNPVIHISFGSGHLQKLEDLEIRFGTILENQEMEYGITLKRPDLRERFAELIYSLYSRFSQKVVILVDEYDKPILDNIEDRDTAAALRDELKNYYSVIKDSDPYIQFVFITGVSKFSKVSLFSGLNNLQDITIDRRYSAICGYTQKDLETVFAERLAGVDLEQVRYWYNGYSWLGEEVYNPFDILLYLDSKELRPYWFETGTPSFLIKLMQERKYFVPDLEQVQASEKLLGSFDVDHLEVETLMFQAGYLTIRKVSQTAGTRRFFLSYPNQEVKQSLTDSLLPYLTGNLSASEKTKFAALDALEAENPEALKDIFHAFFASIPHDWYRKNQLAGYEGYYASIFYCYFAALGLEVIPEDATSMGRIDLTVKLEDKVFICEFKVQGLDKTPGSALEQIRSRRYADQYHAPGRKIYLIGVEFDPRERNIAGFDWESRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQB6</accession>
    <name>D6SQB6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870256.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2334"/>
    <dbReference type="EnsemblBacteria" id="EFI34942">
        <property type="protein sequence ID" value="EFI34942"/>
        <property type="gene ID" value="Dthio_PD2334"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="114" mass="12335" checksum="D28E167390CA5892" modified="2010-08-10" version="1">MQGSLFPAGDREFKDHPKFSGVRIAIQVSSQESSAVGVSQLLIQPGVEIPAHTHDTQADSIYVVSGEGEVYLNGSWHPVAADDYIFAPAGAEHGVRNSGRQELKLFIHHSPPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQD1</accession>
    <name>D6SQD1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870271.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2349"/>
    <dbReference type="EnsemblBacteria" id="EFI34957">
        <property type="protein sequence ID" value="EFI34957"/>
        <property type="gene ID" value="Dthio_PD2349"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="181504at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="423"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="543" mass="60356" checksum="47BF9770767DD053" modified="2010-08-10" version="1">MSHFDPRHLLSELEDNVSKQDRIKADLVLEHIESADAGTRKKLIHILEQGKPEFVGPLLVSLISKRPALQEQLLDLKSALMAVTLQQPGILLKTIEDKVPPREVFISMAGELRLQEAATGLMEILVRELDENILKEAITALGSMGDPAATNSISEFLYSNHKPLTIAATRSLGQIGTPTAMQRLSEKMGSDAQLDILILDIFSQVQDHVSLSKLNQSLSSHYAHLRNYAKSKLVRIGPKAVPMLCDNLMHDDPDLVIHTLNVLGDIGDASALTFIRKMLGKEPKDPNVRFAAYEALGRMPLEKGAYILARGLTDPEEHVCVVAASAIDQNLNQVLAAGVKNMVRQKDQDALKTVRAIVSAQAKNLLVALLEEETFQEMVTDYLVQSAAPEVQEYFRDLLEKYGYRELSQRLKPGDPGEDKRPVAVAVDDSKMILKIYKSTLYELGYEPLVFEYPTEAMKWLRENRPEVVFTDLNMPEITGIDLIGMVREIYPDNSLPIIMVTTQNEVQDNEKARKAGVSDITFKPFTAETLKQALEGAGRPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQF1</accession>
    <name>D6SQF1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyl-viologen-reducing hydrogenase delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870291.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2369"/>
    <dbReference type="EnsemblBacteria" id="EFI34977">
        <property type="protein sequence ID" value="EFI34977"/>
        <property type="gene ID" value="Dthio_PD2369"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1769704at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003813">
        <property type="entry name" value="MvhD/FlpD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02662">
        <property type="entry name" value="FlpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlpD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17053" checksum="B147E96C3929A38F" modified="2010-08-10" version="1">MSALNQNELRIIGFLCNWCSYGGADTAGVGRFSQPTDLRIIRVPCSGRINPLFIARALLNGADGVLVSGCHPRDCHYAEGNFYARRRLEMFQRLLSTMGIEPRRFEYTWVSASEGQRWQTVVTKFTEQIHELGPAPRFGAFQDENPATAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQH2</accession>
    <name>D6SQH2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">Dthio_PD2390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870312.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2390"/>
    <dbReference type="EnsemblBacteria" id="EFI34998">
        <property type="protein sequence ID" value="EFI34998"/>
        <property type="gene ID" value="Dthio_PD2390"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="239" mass="26009" checksum="6FFE25F3346B6436" modified="2010-08-10" version="1">MPKLKYRRVLLKLSGEALAGNEQYGIDPGTVSSICREIISARELGAEIALVIGGGNIFRGVSASSKGMDRASADYMGMLATVMNALAVQDVLEKMNADTRVMSAISMHEVAEPYIRRRALRHLEKKRIVICAAGTGNPFFTTDTAAALRAMELKSDIILKATKVDGVFDRDPVTNPDAVKYDSLTYIDVLSRRLQVMDAAAVSLCMDNCMPVAVFNLFHRDNIIRVLQGEQIGTIVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQJ7</accession>
    <name>D6SQJ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M14 carboxypeptidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870337.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2417"/>
    <dbReference type="EnsemblBacteria" id="EFI35023">
        <property type="protein sequence ID" value="EFI35023"/>
        <property type="gene ID" value="Dthio_PD2417"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088268" evidence="1">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="73"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="310" mass="34593" checksum="B8754FB52997C7B3" modified="2010-08-10" version="1">MNMREIFLGAVFLLVFTLPAATPSPASDEPGEKKSKIDTCTAIDQRLSSVSLGDCVEGGLLESGAYSVRGHPLLVKEYPPLERRAPQSRVLVVGGTHGDEYSSISVTFKWMQILDEHHSGLFHWIFVPLLNPDGLFERPATRTNARGVDINRNKPSPLWREVGYTRWQEMTDENPRYYPGPYPVSEPETEFLVHLIRSFRPDAVISLHSPLNLVDYDGPGNPPRSLGSLWLRRLGNFPGTLGNFAGKKMGIPVITVELASSARMPSGGEISSMWRDLVRWLINETPVEPGPGQLQALDQDMQLRKEFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQL6</accession>
    <name>D6SQL6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35042">
        <property type="protein sequence ID" value="EFI35042"/>
        <property type="gene ID" value="Dthio_PD2436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="44" mass="5042" checksum="6B803E31E3704EC4" modified="2010-08-10" version="1">MTSWPTWSRLWDSLGHRAWGMGLGEEEGEGIGDWLINGKHFIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQM5</accession>
    <name>D6SQM5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870365.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2445"/>
    <dbReference type="EnsemblBacteria" id="EFI35051">
        <property type="protein sequence ID" value="EFI35051"/>
        <property type="gene ID" value="Dthio_PD2445"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="198"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="264"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="354" mass="39725" checksum="89B10FB692884501" modified="2010-08-10" version="1">MWELIIAFSLAVVVSAFCSIAEAALYSVPWSFIERLKKEKKKSGELLYKLRSRIDQPITAILTLNTLANTAGAAIAGAAAASVFGAQNLIYFSIVFTLTILIFSEIIPKTMGVVFNRRVAPILAKPLVALVWVLKPVIVVCRYLVVFIERKKAGPTTSEEDLLAMLSLTRRSGVIKPYEELTIQNILSLDKKMVRDIMTPRMVIFSLPAKMTVSEAREYKTFWPHSRIPVYEGDDPEDVVGIVSRSQILDALARDQDHIRLEDLMRRVDFVVETMSLDRLLIKCLNSRVHLFMVLDEYGGIAGLVTLEDVMEEILGKEIVDETDEVVDMREMARQSRAELKSRSRSGVGEKGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQR8</accession>
    <name>D6SQR8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="ORF">Dthio_PD2488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870408.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2488"/>
    <dbReference type="EnsemblBacteria" id="EFI35094">
        <property type="protein sequence ID" value="EFI35094"/>
        <property type="gene ID" value="Dthio_PD2488"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="107"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="242"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="35422" checksum="35B4638281ABFEA8" modified="2010-08-10" version="1">MKKNCCLTGLGYYVPEKVITNHDFELLMDTSDEWITTRTGIKQRHICTDQACSDLAYHSSIQALEEAGITPQDLTHIIVATFTPDALIPNAACVLLEKLGHKDIAALDINTACTGFIYGLELARGLCMLPGDANVLVVASEALTTRVNFSDRSTCVLFGDGAGAAVVSNTCHNPAAMPGRLLDVSLKADGALGELLTIKGGGSAYPLALGEKVSENFFVQMEGREVFKHAVRSMYNVALEVMARNNVRPGDIDLVVPHQANIRIIEALAKKMNLDPANLFVNVQKYGNTSAASVPIALAEAREKGRISPGDLVLMVAFGGGFTWGAALVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQZ3</accession>
    <name>D6SQZ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Host attachment protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870483.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2567"/>
    <dbReference type="EnsemblBacteria" id="EFI35169">
        <property type="protein sequence ID" value="EFI35169"/>
        <property type="gene ID" value="Dthio_PD2567"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1859504at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019291">
        <property type="entry name" value="Host_attachment_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10116">
        <property type="entry name" value="Host_attach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="147" mass="17092" checksum="376B2E199D934BF5" modified="2010-08-10" version="1">MDYKAWVVVADSSQARIFGANSRGGGLTELEKFEHPESRMKDQDLKTDKAGRMYSMQGEFRTTAEQTPARKMEAERFAQKLADHLEKSQHNNKFERLILVAAPSFLGMLRNSLKDTTRRTLSNELDKDLCRVEKPEEIRKRLPEYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQZ7</accession>
    <name>D6SQZ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2571"/>
    <dbReference type="EnsemblBacteria" id="EFI35173">
        <property type="protein sequence ID" value="EFI35173"/>
        <property type="gene ID" value="Dthio_PD2571"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034CGH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="48" mass="5938" checksum="A53DA7C5649F23A9" modified="2010-08-10" version="1">MKKVKCFIQHHFNPLHVYCRLRSAGFRPVMAQRVCTLYEKFFYNFLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR68</accession>
    <name>D6SR68_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870542.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0510"/>
    <dbReference type="EnsemblBacteria" id="EFI33184">
        <property type="protein sequence ID" value="EFI33184"/>
        <property type="gene ID" value="Dthio_PD0510"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2033817at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="114" mass="13690" checksum="97ACE3B837ACF918" modified="2010-08-10" version="1">MKQGKRKGTYTHNYDPDRLRQLIKDKKDAKAIMKDLQISRYSLYEQLLMLQDEDNELYEIPGLLDPPTLEERRWWKYKKDGVIFSEKMLQYTGFKPGDAFEMVVEDDRVILKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRA3</accession>
    <name>D6SRA3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0545"/>
    <dbReference type="EnsemblBacteria" id="EFI33219">
        <property type="protein sequence ID" value="EFI33219"/>
        <property type="gene ID" value="Dthio_PD0545"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCJY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="863455at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Zn_dep_PLPC" evidence="2">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="243" mass="27622" checksum="0B32A34D88E69261" modified="2010-08-10" version="1">MKKIFILFLIIFFVSAENAFAWGPMTHTHFAFEILRAASLLPVAVYSLLTAYSTNFIYGSVVADYFLGKPGQKNPHDWETGFMLLQAAGKRTDQAFACGFLSHLAADTVAHGKMDLGSRGKLGHAWVEMESDSLVTRKCWPAVARMDKSRLKSNDRLARKVIDPKDCRSKGFQGVYRAYLSMSGLNRRRITSYYHEDFDKYHQMSVQRAIDVLSRKESSTYVRMTPNIKKKKKVLTALKSIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRE1</accession>
    <name>D6SRE1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0583"/>
    <dbReference type="EnsemblBacteria" id="EFI33257">
        <property type="protein sequence ID" value="EFI33257"/>
        <property type="gene ID" value="Dthio_PD0583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="52" mass="5937" checksum="5651409510585F7D" modified="2010-08-10" version="1">MEEVWGRGKNVWVYGSMGVWEWEEEEMEHGAGGRTCGCMGVKRIACAVRKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRE8</accession>
    <name>D6SRE8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ORF">Dthio_PD0590</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870622.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0590"/>
    <dbReference type="EnsemblBacteria" id="EFI33264">
        <property type="protein sequence ID" value="EFI33264"/>
        <property type="gene ID" value="Dthio_PD0590"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="141"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="375"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="443" mass="50019" checksum="FA69F226FA9EAD82" modified="2010-08-10" version="1">MNYYIFTFGCQMNVSDSLWLDQALQALGLKPCSREEEADIFLINTCSVREKPEQKIYSLLGRLYEYTREKPHVFAGVGGCVAQQVGRRFLERFSFVRLVFGTDGLVMVPEAIKRLLKDRHLKTSLLDFQDHYPERKGYQPEKAPVQAFVNIMQGCDNFCAYCIVPYTRGRQKSRSSREILQECAGLVARGCREITLLGQNVNSFGQDKEGRDIPFSELLRSVAALPGLERLRFTTSHPKDIDEEVIQAFGELPALCPHLHLPLQSGSDQVLSSMGRKYNSDDYLRIVEKLRSSCPDISLTTDLIVGFPGETDADFEDTMDIVKKVGFDSSFSFKYSDRPGVRAADMQPKIDDETKTERLARLQQLQSELTRDRLAGRVGRQELVLVEGRSKKQGPPDTVSWTGRDPGGRLVHVHLPVERDCTGEVLRVTIVRAHKHSLSGEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRH3</accession>
    <name>D6SRH3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Basal-body rod modification protein FlgD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Required for flagellar hook formation. May act as a scaffolding protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FlgD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870647.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0615"/>
    <dbReference type="EnsemblBacteria" id="EFI33289">
        <property type="protein sequence ID" value="EFI33289"/>
        <property type="gene ID" value="Dthio_PD0615"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="709873at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025965">
        <property type="entry name" value="FlgD_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025963">
        <property type="entry name" value="FLgD_Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13860">
        <property type="entry name" value="FlgD_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13861">
        <property type="entry name" value="FLgD_tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FLgD_tudor" evidence="7">
        <location>
            <begin position="90"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="FlgD_ig" evidence="6">
        <location>
            <begin position="106"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="26404" checksum="9F418D8A10ABC197" modified="2010-08-10" version="1">MDIGAASNLLGGYERDFANNDIPRDEDPAELGKMDFLKLLITQLENQDPLDPMDDKEFVAQLAQFSSLEQLTNISEGMESMNENQARQEMLGAVGFIGKEIRADGDGISKDGSGASKIFYNLEDTAQNLYFNIYDENGNMVRTVEKSARQSGDYEFEWDGLNFDGAEAPDGNYSVSISAEGPNGEPVMVNTEMTGRVSGVQDKDGQPHLRLSDGRMLRFADVSEVVGDGSSNSNNNNTEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRH8</accession>
    <name>D6SRH8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-tyrosyl-tRNA(Tyr) deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870652.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0620"/>
    <dbReference type="EnsemblBacteria" id="EFI33294">
        <property type="protein sequence ID" value="EFI33294"/>
        <property type="gene ID" value="Dthio_PD0620"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1862614at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="156" mass="17737" checksum="B5F3C5DB86CFFE06" modified="2010-08-10" version="1">MRVLLQRTKWAGVKTVVDQEPREVRVDRGLTGLVGFFREDAGLPGTRAWETMVGKILNLRIFPDENQRMNLSLADIQGDLLLVPQFTLYADCRKGRRPGFSDSMPGDKAQELFGSFVSRVEQSWDRVYAGFFGADMDVELCNWGPVTIMLDSRDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS89</accession>
    <name>D6SS89_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical cytosolic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870905.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0889"/>
    <dbReference type="EnsemblBacteria" id="EFI33555">
        <property type="protein sequence ID" value="EFI33555"/>
        <property type="gene ID" value="Dthio_PD0889"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50336AV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1945916at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10562" checksum="8BBA4B543C4234EC" modified="2010-08-10" version="1">MAWSVRVKKKAVKKARELPRTAKENLFALMREMEESGPVRGNWKNYSKLGKNRHHCHIKGGHPAYVAVWEESEGEINLIEVTYAGTHEDAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSA4</accession>
    <name>D6SSA4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870920.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0904"/>
    <dbReference type="EnsemblBacteria" id="EFI33570">
        <property type="protein sequence ID" value="EFI33570"/>
        <property type="gene ID" value="Dthio_PD0904"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925819at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8174" checksum="246743144BA76C05" modified="2010-08-10" version="1">MKIIYDQETDTLTLIFSEATIEESDEDKPGVILDYDSTGNLVSMEILEASKRVMKPSAIEYHVAPEAKPATVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSL2</accession>
    <name>D6SSL2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871027.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1014"/>
    <dbReference type="EnsemblBacteria" id="EFI33678">
        <property type="protein sequence ID" value="EFI33678"/>
        <property type="gene ID" value="Dthio_PD1014"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="710317at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="entry name" value="PTHR43511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="481" mass="54895" checksum="0C2FFD2487C8EB5A" modified="2010-08-10" version="1">MDSKNLECISNTDPDLMQMFKAYALKMEEQSLPPIVVNLFKCYFSQLLYGSQGKLTQQEIIPVEQNELESLDSISKYREKVPEAISELAVIKLNGGLGTSMGLEKAKSLIKVREEKSFLNLIAEQIKVLREKYQTRVPLLFMNSFRTHMDTMMHVQEIDNPYHLPQAFLQHKYPKILTDDLSPAKWPENPELEWNPPGHGDIYTALVTSGVLKNLLEKGYKYAFISNSDNLGATVDENILGYLKAKEFTFLMEVTPRTITDRKGGHLCRLLKNDRLAVREIAQCPENELEDFMDIQKYSFFNTNSIWLNLEELEKVFVRHRMVPLDLIINTKNLDPRNPDSPKVYQLETAMGSAISAFDHAGALNVPRDRFAPVKTTSDLLAVKSDLYEMTDMMTIVPNPRRKDPMPDIHLDSGFFKNIDQFEDRFAAGIPSLLECQELRVEGNVYFGRDVKIKGNTFIRNTSAKPVTIQDGSELEGQVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSS7</accession>
    <name>D6SSS7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871092.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1082"/>
    <dbReference type="EnsemblBacteria" id="EFI33743">
        <property type="protein sequence ID" value="EFI33743"/>
        <property type="gene ID" value="Dthio_PD1082"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="13161" checksum="A80665B9009398CE" modified="2010-08-10" version="1">MGKTIMTVDDSSSVRQMVSFTLKDAGYSVVEAADGKDALQKLQGQVDMIITDLNMPNMDGIELIKNVRATSGYKFIPIVMLTTESQDEKKQEGKKAGASGWIVKPFKPPQILSVVQKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSU2</accession>
    <name>D6SSU2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ORF">Dthio_PD1097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871107.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1097"/>
    <dbReference type="EnsemblBacteria" id="EFI33758">
        <property type="protein sequence ID" value="EFI33758"/>
        <property type="gene ID" value="Dthio_PD1097"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1995603at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="117" mass="13137" checksum="380C2DC3EE8D6620" modified="2010-08-10" version="1">MHEMSIAQNLIRIVEQEMAQNDARRLLRVKISYGRISAIVPEALQTAFQALTSQTPLEGAVLETREVPLKVRCRECAAEFSPQDRDMLIMTCTSCGAEFGHEVISGKELLVEEMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST80</accession>
    <name>D6ST80_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase (Ubiquinone) 30 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871245.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1235"/>
    <dbReference type="EnsemblBacteria" id="EFI33896">
        <property type="protein sequence ID" value="EFI33896"/>
        <property type="gene ID" value="Dthio_PD1235"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735902at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="2">
        <location>
            <begin position="45"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="195" mass="21856" checksum="B289D2869E91B25A" modified="2010-08-10" version="1">MSEENAQPEQAAEKTKKAEKAAGKEAKKEEPQGPAYTGYDADFFVTPQDLLNAVGKLDQAGFFLEDVSCVDMQEGFQMVYHFDRFDQPGRVGIRVMISKENPEVPSIYDIYPGAAWHERECFDFFGVRFKGHPNLLPLLLAPDHDGPPPLLKEESALKDLHQIYPDRAHSPVSADSQEFIQAITNCSNKPSRDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6STD9</accession>
    <name>D6STD9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mobA</name>
        <name evidence="6" type="ORF">Dthio_PD1294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871304.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1294"/>
    <dbReference type="EnsemblBacteria" id="EFI33955">
        <property type="protein sequence ID" value="EFI33955"/>
        <property type="gene ID" value="Dthio_PD1294"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019898at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="200" mass="22251" checksum="72D2F8582FFB0D51" modified="2010-08-10" version="1">MTAQDLSAVILAGGKSTRLGRDKTRVRIQGQTLVQRMVSLARRFCRSTWVVGQHPEQVDAPWMLDEIPGIGPMGGIITALKRLSSPCLVLACDLPAMHEDLLARLIAHRSSSPGRQCMTTFMQEQTGYIESLVAVYETRCLDLLLASYEKGCYRLSTAVPPEYRLHIPYGIQEEHFFFNVNYPGDLEKILAEVNPGTLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6STF8</accession>
    <name>D6STF8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1313"/>
    <dbReference type="EnsemblBacteria" id="EFI33974">
        <property type="protein sequence ID" value="EFI33974"/>
        <property type="gene ID" value="Dthio_PD1313"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="3">
        <location>
            <begin position="96"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="36177" checksum="251995167042F60F" modified="2010-08-10" version="1">MQDMQKQTAQQCLVSSTESGQKLFSYLKRRLGREFPGSGLMRLIRTGQVRVNSKRKKPYDRVYAGDTVRIPPHFPETGDDPQRAGELQIVFENPDFTVLDKPAGVPVHSGTSARRDNMVLRLRKHYAGADFSPALVHRLDKETSGLLLAAKNYAWLRRIQAMWNKNLVEKTYLAWVHGSWPSRWVNLEHRLIKTFEKMQPSPEGRPALSRVRSIASSRDKTLVQIRIITGRTHQIRTQLSLSGHPVIGDGKYGKDSGYAEMYLHAYMLAWPGHVFCLPPGWTGDFTTPGDLEKRVRKPESGRGGRSRCKEDACHHPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STG1</accession>
    <name>D6STG1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871326.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1316"/>
    <dbReference type="EnsemblBacteria" id="EFI33977">
        <property type="protein sequence ID" value="EFI33977"/>
        <property type="gene ID" value="Dthio_PD1316"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031XBJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1272112at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="22429" checksum="3CA35A78443902F6" modified="2010-08-10" version="1">MPPWGKITIFLVLALLLAGCRGHKAAEFLWPDLGDPYVQTTNEWTRKDSLHSGLDTEIIARATYKSPEWMQAYIKKRAEVYGLTSDEKVQLRQNLEDSLEHETRFFLALAKGHKARGSLKFDDPLWSIFLLHEGRKIYPLEIRESREPLAKLESFYPYVNRWQDHYVLRFPPVNGDSIDLVMSGPLGRVELNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6STK5</accession>
    <name>D6STK5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1360"/>
    <dbReference type="EnsemblBacteria" id="EFI34021">
        <property type="protein sequence ID" value="EFI34021"/>
        <property type="gene ID" value="Dthio_PD1360"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="263" mass="30043" checksum="AC9A5A7FC9747F1B" modified="2010-08-10" version="1">MPKTSQHTISITVIIPTADRNHTLDRAIRSVLNQTLKPDKIIVVDNGYQHAETHEDIKQQVHFIKTMPRLGPGKARNAGAAIAETEYISFLDDDDVWEKDYLKYSIEALKITCADAVVGQLKKADPHGQAKAYKMFPADPKKQRKVYFKSPGFGGQNLVISKKMFALVGGFDETMPASVDRDLAAKIIEHRGFIVPQPYSVAVLHNHESARVRDNIVLGNIMFIQKHWKHMTFFEIFMAFKTLIKRYLKLKLKHRNIKTLFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6STM5</accession>
    <name>D6STM5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871390.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1380"/>
    <dbReference type="EnsemblBacteria" id="EFI34041">
        <property type="protein sequence ID" value="EFI34041"/>
        <property type="gene ID" value="Dthio_PD1380"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="384" mass="43770" checksum="69F3F869B6A0283A" modified="2010-08-10" version="1">MLDKEKTILVVDDIQPSRETVINCLRVLGYKNTREAADGKEALEVLEKSQDIQLVISDWKMPRMNGVDLLRSMRSESRWEDLPFIFLTSKSESEDVAEASDLGVTEYMIKPLSIDVFAEKVDSLGSGNPRQKLSTVLKGVKKDCSRKDFSRAVTRLTGLLEELPSMRSRIYFEMASVYFQAGEIKRARAVVEQALSINHLLGKAWFLKAELEKEEQNWQEARASLNRALEIQPRNADYFLCLGDTLLYLEDNMKARESFQRAMNIAPEEDWIKTRTWDIYLKHDLCREAEASFGSLLINCLSSDVLNNYAVALRKKGEMARAVELYAVALKKDPDNPGLLFNAAVSDYYNGNFRRAVNRLERAIELQPGFAQAEAFLKKLTKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STS9</accession>
    <name>D6STS9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871444.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1435"/>
    <dbReference type="EnsemblBacteria" id="EFI34095">
        <property type="protein sequence ID" value="EFI34095"/>
        <property type="gene ID" value="Dthio_PD1435"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZPW6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8965" checksum="D14110135D04765D" modified="2010-08-10" version="1">MKMYGRDVSDLSVHEINKLFRQYDESHKWPVCNQFNATDRAIGRLRRNILPHVGPTGGIEYAYMLDEEISQIVNTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STY8</accession>
    <name>D6STY8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871503.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1496"/>
    <dbReference type="EnsemblBacteria" id="EFI34154">
        <property type="protein sequence ID" value="EFI34154"/>
        <property type="gene ID" value="Dthio_PD1496"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1692541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="166" mass="19541" checksum="704A1F2DFE206919" modified="2010-08-10" version="1">MKAATALLKADIQDELSKLEKVYNEFKSFAPKLDLKDDEMGNYDKIVVGYLLHSFYNGCENIFRSVAAFFENDLGTGSWHKDLLRRMRLEITGYRPRVISDELYACLDDFRGFRHRFRHSYGFELDWEREKVVARKMDKAFQLMQEELTVFMSRLDSLDGLEADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU08</accession>
    <name>D6SU08_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0414"/>
    <dbReference type="EnsemblBacteria" id="EFI33099">
        <property type="protein sequence ID" value="EFI33099"/>
        <property type="gene ID" value="Dthio_PD0414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9321" checksum="6AA828F0DBC23A7E" modified="2010-08-10" version="1">MFCGNGPQKQAQQPCCCRAGRSARFKRTNEVDSCPSLTSSVAVPYPSWHADVLREREIEYKEGSSGFTDWPEAKKRIRNQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUA5</accession>
    <name>D6SUA5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871578.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0199"/>
    <dbReference type="EnsemblBacteria" id="EFI32885">
        <property type="protein sequence ID" value="EFI32885"/>
        <property type="gene ID" value="Dthio_PD0199"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="961884at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="472"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="569" mass="64399" checksum="468ACE130A411108" modified="2010-08-10" version="1">MIKTDIPRPWLEYYDSEVSSSLDYEDIPVYEYLDRVASKHPRRRAIIFNNWKINYKKLQELTENVAANLRSYGLSPGDRVAIMLPNLPQTVITYWGVLKAGGTVVMTNPLYMEKEILHHFGDSESKFLITLDMLWPKLSELLPRLGLERVFVTSIPDCLRFPLTWLYRFKMHREKKAVDIPYDEEKILPWTSLIQKGEVFLKYTPEPRQDLAVLQYTGGTTGMSKGVMLTHYNLAANVRQAMSMLHNIQLGEHTVLGLLPYFHIYGLTVCVNFATAIGATLAPYPRFVPRDVLKAIHKIKPTIFPSAPAVFQALLQQKDIDSYDLSSIDYCISGSAPIPRESIEKFNKTTGAEIIEGYGLTEASPITHFNPLRGKRKIGSIGLPFPDTDAAIVDMDSGEGPLSSNETGELIVKGPQVMKGYWNQQEETAQTLRDGWLYTGDIAYMDEEGYFYIVDRKKDLIITGGYNVYPREIDEVLYEHPGVKEAVTVGIPNSTRGEVVKAFVVPKEGQELTRADIVSFCKQKLASFKVPKQIEFREELPKTIVGKVLRRALREEEMAKRKGGDGNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUA6</accession>
    <name>D6SUA6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="6">3.4.21.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.</text>
            <dbReference type="EC" id="3.4.21.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871579.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0200"/>
    <dbReference type="MEROPS" id="S01.453"/>
    <dbReference type="EnsemblBacteria" id="EFI32886">
        <property type="protein sequence ID" value="EFI32886"/>
        <property type="gene ID" value="Dthio_PD0200"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="257"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="374"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="472" mass="51243" checksum="4E83D7E2620B7504" modified="2010-08-10" version="1">MRLYIKTFLLLTLFFIWSGSIAGASLPEFSDLAEKAGPAVVNISTVKKVERPEMGDFFRGFQDRGHPFEEFFDQFERFFGERERQPREQRSLGSGFIISQDGYVVTNNHVVEGAEEIKATFRLEDEEKTFEAEIIGTDPETDLALIKINTDMELPTLEFGNSEDMKVGQWVVAIGNPFGLNHTVTAGIISAKGRVIGAGPYDNFIQTDASINPGNSGGPLLNMQGEVIGINTAIVAAGQGIGFAIPSTMAEDIISQLKTDQKVSRGWLGVTIQNVDQDIADALGLEEARGALVAGVTPGDPAEEAGMEAGDVIVSLNGDSVEDSSDLTRKIGQLAPGSEATVGFYRDGEKKDVTVTLGERDLEGLAERPEPEPESEKADLGMSFRSPSQEEAEQLGLSEPQGLLVTEVEPRSPAHRADIAPGDLILQANGQRVDSTNDFFTILEEDAKPKQVLMLLVNRQGQNIFRTIPLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUN9</accession>
    <name>D6SUN9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="10" type="ORF">Dthio_PD0333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871712.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0333"/>
    <dbReference type="EnsemblBacteria" id="EFI33019">
        <property type="protein sequence ID" value="EFI33019"/>
        <property type="gene ID" value="Dthio_PD0333"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="9">
        <location>
            <begin position="241"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="808"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="882"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="889"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="892"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1386" mass="154511" checksum="B946E6BA546548AB" modified="2010-08-10" version="1">MSLDDLFSQRSSSTSTISGKELKGIKIRVASPEKVREWSFGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECNCGKYKRMKHRGIVCEKCGVEVIASKVRRDRMGHIELAAPVAHIWFLKSLPSKIGTLLDMTMADLEKVLYFDAYMVLDPGETSLNLKQVISEEQYLQVLETYGENAVRVGMGAEVVREFLMNLDLEKLRAELREESEGTRSQTKKKKLAKRLRIVEAFLESGNRCEWMVLETIPVIPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELGAPDIIIRNEKRMLQEAVDALLDNGRRGKAISGTNGRPLKSLSDMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPNLKLHQCGLPKKMALELFKPFLYSRLEEKGYASTIKSAKKMVERGDVVVWDILDEVVKEYPVLLNRAPTLHRLGIQAFEPILVEGKAIRLHPLVCSAFNADFDGDQMAVHVPLSIEANVECRVLIMSTNNILSPANGEPVIVPSQDIVLGLYYLTVDRSMQKGEGKIFCDPGEVICAYDAGHLDLHARIKVRIDGELHDTTTGRIIVNDLLPDNVPFSLVNCILNKKNIGRLVGNTYRWAGTKATVILCDRIKDLGYEYSTLAGITIGVKDLTIPEKKKTIIDTSQETINEIERQYNEGIITRTEKYNKVVDVWTKATNDVSNEMMKKLSTDIVRDPETGREESNVSLNPIFMMANSGARGNKDQMRQLAGMRGLMAKPSGEIIETPIISCFREGLTVLQYFTSTHGARKGLADTALKTANSGYLTRRLVDVVQDVVVSEFDCGTVDGIELTHLMKAGEVQARLSERILGRIAMYDILDPETGEVIVAGNSMITEDDAEKIDAAGINAVSIRSALTCKTKRGVCSLCYGRDLARGHLVNVGETVGIIAAQSIGEPGTQLTMRTFHIGGTASKEIERSNIKASNVGHVVFSRIRTVENTKGEFMVMGKSGQLKIVDDQGREREKYFLPTGAKLFVRADEKVSKGQMLAEWDPFNEPFVTDIEGRIKFSDIIEGRTYQEKVDETTGRATMTITEYRSTNFRPSVSICDDKGRVKMRPETSSEAIFQLPVGAILMVQDGDKVQAGDIIARKPRESSKTKDIVGGLPRVAELFEVRKPKDQAVVTEIDGIVSFGPESKGKRKIIIGPEVGEPKEYLIPKGKHITVQEGDFVESGELITEGNPDLHDMLKIKGEKYLANYLVEEVQDVYRFQGVQINDKHIEVIVRQMLKKVNIIDPGDTGFLVGQQVEKTVFMKENEKSLRKGKNPAMAEPVVLGITQASLTTESFISAASFQETTKVLTEAALMGKVDQLRGLKENVIVGRLIPAGTGYRPYVNCGITVPDQPEDPEEFMEDLDDQVYIGRQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUP4</accession>
    <name>D6SUP4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplK</name>
        <name evidence="12" type="ORF">Dthio_PD0338</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7 9">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871717.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0338"/>
    <dbReference type="EnsemblBacteria" id="EFI33024">
        <property type="protein sequence ID" value="EFI33024"/>
        <property type="gene ID" value="Dthio_PD0338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="11">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="10">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="141" mass="15071" checksum="49D8F84F05CC45AC" modified="2010-08-10" version="1">MAKKVKAKIKLQIPGGAANPSPPVGPALGQHGVNIMEFCKAFNAKTQEDKGMIIPVVITVYQDRSFTFITKTPPAPVLLKKAAKLDKGTGEAKKVKVGKVTQDQVDEIARVKMPDLTASDMKAARKTIVGTAKSMGIEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUR2</accession>
    <name>D6SUR2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871735.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0356"/>
    <dbReference type="EnsemblBacteria" id="EFI33042">
        <property type="protein sequence ID" value="EFI33042"/>
        <property type="gene ID" value="Dthio_PD0356"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="285" mass="31391" checksum="6309E6FD1B862C80" modified="2010-08-10" version="1">MSEIDLHTHSTASDGTMTPYELVSHARNIGLKALALTDHDTTKGLMQALQAGNDLGLEVVPGCELSVEYPGLMHILGLWLRSDAPALNKAMQELRDKRNMRNEVIIEKLQKLGIDISYAEVQTLAGDASVGRPHISRVLMDKGVVTSVQECFDRYLGSTGKAYVPKEKFDPEKAISVLKDENALVILAHPFSLQLDTDALRRELVRLKDLGLDGVEVFYSEHTIEQTEIYASLCRELDLLPTGGSDFHGSVKPEIGLGSGRGNLNLSYALLKALKEKRLENGLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV62</accession>
    <name>D6SV62_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0122"/>
    <dbReference type="EnsemblBacteria" id="EFI32818">
        <property type="protein sequence ID" value="EFI32818"/>
        <property type="gene ID" value="Dthio_PD0122"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="8"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="38861" checksum="1ED418A3F1F908BB" modified="2010-08-10" version="1">MSDTSKYHDHTFRAILGREPVARDFVRYHLPEEITRDMNLDTVKVSSRSYVSDNLKESMTDIVITLQLNTGEPAEIYILVEHKSDLDAWTKIQLFKYMNEVWQSFIQKKTGTLPIIIPLVFYHGTARWNYSLEFSDLFNLPSEHYRKYIPNFEHLLHEVPEINKKKAKTSITLEVFHQVLEYIFYPEKRDQIYEALELLFKGLDAKEAHEIFAILIKYLLIATDETPEEAEEKVKHLPKGGETVRTTAEVLEERGYNKAIKEKPIWERQAELKNAKETLIDVATEAYGPLPGSLYEKIKSIQSLENLRALNRKVIRTQSLEEFTELVNRAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJR3</accession>
    <name>D6SJR3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869241.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3568"/>
    <dbReference type="EnsemblBacteria" id="EFI36116">
        <property type="protein sequence ID" value="EFI36116"/>
        <property type="gene ID" value="Dthio_PD3568"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="10767" checksum="CC18A995C61AF32D" modified="2010-08-10" version="1">MPMKNPPHPGLFVKAEVLDSLNLSISEAAGLLGVRRATLSALVNQKTSLSPEMAYRIEKAFGVSMDMLLRMQAGFDVCKMRQKKPEIIVKPYKPAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJU2</accession>
    <name>D6SJU2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869270.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3599"/>
    <dbReference type="EnsemblBacteria" id="EFI36145">
        <property type="protein sequence ID" value="EFI36145"/>
        <property type="gene ID" value="Dthio_PD3599"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1808979at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024755">
        <property type="entry name" value="cpYpsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12694">
        <property type="entry name" value="cpYpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="168" mass="18636" checksum="5504E22DEB6BC338" modified="2010-08-10" version="1">MTKRKIFEKIITGGQTGAALGALDAALELGHPCGGWCPKGRKSEAGPIPAKYPVQELDSADYRVRNKQNVIDSDGTMIFTYGKPTGGTNLTFNMAIKHEKPLYVCDLEDDPLNKDIDFIWEWGLESDVYVLNVAGPRESKHPNTQVLVKTVMFMLLEHARKSYPVVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJV4</accession>
    <name>D6SJV4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869279.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36157">
        <property type="protein sequence ID" value="EFI36157"/>
        <property type="gene ID" value="Dthio_PD3613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11123" checksum="D08858172BE1228D" modified="2010-08-10" version="1">MEIILLIALAGVIFWFFIMKTGNIDFWKLAQKHPEEAYSFFVNNNNFIVFDHKPAGGFRSSLPPGDWDGPFKLRVPSKDATVTVYGRSPEYEEVLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK19</accession>
    <name>D6SK19_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNF2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869344.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3679"/>
    <dbReference type="EnsemblBacteria" id="EFI36222">
        <property type="protein sequence ID" value="EFI36222"/>
        <property type="gene ID" value="Dthio_PD3679"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="325071at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="942"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1387" mass="155948" checksum="2E0D8CF3370BEC2C" modified="2010-08-10" version="1">MDKLLSKIEELSPVESKILHICALAAPVSSSDAIHFLLQLSHALLPGHLKKDPLALQPYLVKLQKGGFLDADLELSPGIREVVSRQAAREPDFKKISKAIKDKWPRFHSSFYSPKGVRYDLAARDLRLDVLSGDTDAFMADLRYYYQHVFYDDTTRPSPLFSICANPFDPLWMKTLPAVIQDAMLEELLFLFSVRGINPGSEVVDYASEYVTQKIVSSFSALKQKFILCTVSLMSADLAQARKQISGLGFERLESMGKGWISFLKGEDDRATDLFAKALKDLRQGYRSKKIFFSDSSGQVYLLSLLRKQSPKSLKQLRTLLGDLDNQVNQNSRDVLKPALYGLQAILHYIDMKEEAALEKLGNMPSHPDLITGFTCNLARYWIKNKLTPTQQKEVRSILDRAMDCGFHWMSIEAGSLLMATHPKVLEQKERDYIQDIVRQTGIRPMSDLVQPVEKWKMALQALQKAADEQGDTGKKQRLVWLVSIEHGQLQRLQPKLQNQTAKGAWTKGRNVALKVLFYQSGGLDYLSSHDQRLITSLNKYFDGYRSNWFEFKLDQALPMLVGHPRVFLENDLNTPVEFVRGEPEISVVKSGQGYKLSMTPDLRQHAQVAVQETPYRYRVVQASDAHRRLAGVLGSKGVKVPGQGRGELLKTISAISGMVTIHSDLPEQTGDIPEVAGDAVPCFRIYPAGSGFKADMVVRPFGDAGPFVRPGQGRAALMAEVRNKRMLARRDLELEASKAAAVEAACPSLEEFEGRDNLWIIEDPAGCLDLLSELKDLQEQDMVRVLWPEGEKMRIARKVNLDDLELELTSRQEWFEVDGQISVDQETVLKLKDLLKSFEEQDVRFVSLDDKSYVALTGKLRRRLGEMGQLAEVGKDGIRLPAHSILALEDLDREAGSFKGDKAWSSRKQEIRQALSASPAPPSTLRADLRPYQEEGYQWLSRMASMGLGACLADDMGLGKTLQALAVILERASKGPTLVVAPTSVCPNWLSESARFAPTLKPLLYYGKDRQGQLAQAGPFDLIVCSYALLMQDAQHLSRVDWQSVVLDEAQAIKNWSAKRTQAAMNLSAGFRMATTGTPIENNLTELWTLFRFLNPGLLGARKKFNEKFVLPIQKQENSERKKTLKRIIQPFILRRVKSQVLEELPSRTEVTLKVSLSPEETAMYEAMRMQALENLEQVSEQGGARNLRILTELTRLRQFCCHPRMVVPESRVPGSKLDLLQEIITELLANKHKALVFSQFVKHLALVRERLEAMGIEYRYLDGSTPGHVREQEIQAFQEGRGDLFLISLKAGGLGLNLTAADYVIHLDPWWNPAVEDQATDRSHRIGQENPVTVYRLVAENTIEEKIVRLHAEKRDLADSLLEGTDSGSRVSAEELMQLLRDPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK46</accession>
    <name>D6SK46_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS66 Orf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0024</name>
        <name evidence="2" type="ORF">Dthio_PD1740</name>
        <name evidence="3" type="ORF">Dthio_PD3706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869371.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0024"/>
    <dbReference type="EnsemblBacteria" id="EFI32738">
        <property type="protein sequence ID" value="EFI32738"/>
        <property type="gene ID" value="Dthio_PD0024"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34387">
        <property type="protein sequence ID" value="EFI34387"/>
        <property type="gene ID" value="Dthio_PD1740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36249">
        <property type="protein sequence ID" value="EFI36249"/>
        <property type="gene ID" value="Dthio_PD3706"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1680806at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="13837" checksum="5E12A7BDFAD54EC8" modified="2010-08-10" version="1">MIQLTPQMRILVAVEPVDFRKGIDGLTKICRQRIKSDPFSGCVFVFCNKKKTAIKIITYDGQGFWLCQKRLSQGTFQWWPDKSQSGICPLAVHELQLLIWNGNPQNAQVAPQWRKILTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK88</accession>
    <name>D6SK88_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869410.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36291">
        <property type="protein sequence ID" value="EFI36291"/>
        <property type="gene ID" value="Dthio_PD3754"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZWFA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923009at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="139" mass="15582" checksum="7F3F348B72D2B9F8" modified="2010-08-10" version="1">MKKYIYWGLVVLLVLGAGCGKKVWPEPEADDERFEIKIEQARLEGECLHIQARLKGNYQNLAGVILEVEESVVPCPGCPFMATFSEVLPPGAQEVHMEGDLLQVSLCGFDPEKYNRVRLTGVNVYRDLGDVHSSVKELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKH2</accession>
    <name>D6SKH2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869491.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3846"/>
    <dbReference type="EnsemblBacteria" id="EFI36375">
        <property type="protein sequence ID" value="EFI36375"/>
        <property type="gene ID" value="Dthio_PD3846"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1995897at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10335" checksum="2C679F86845238D4" modified="2010-08-10" version="1">MIQTNTTQAVSGACFQEKPIILKLSLESILEKYAPDNAEHFPMPRDSTLVDLLKHLGLGEDQVMLAFVNGRMANLKTRLADRDAVSLCPYICGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKM2</accession>
    <name>D6SKM2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868367.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2644"/>
    <dbReference type="EnsemblBacteria" id="EFI35233">
        <property type="protein sequence ID" value="EFI35233"/>
        <property type="gene ID" value="Dthio_PD2644"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033GEX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2085932at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15118" checksum="4EAE77F842029ACD" modified="2010-08-10" version="1">MHQQSAPSTRPGLEEVKRQFEHWRETRHTRSPIPNHLWASAVSLAQDYSICKIAKVLHLNHSHLKKRVLAEQAQESLQPGPSFVEFELTSSLPCTEYHLETEARDGSKLKMQLKGPDLPNPLEILSAFWSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKN9</accession>
    <name>D6SKN9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868383.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2661"/>
    <dbReference type="EnsemblBacteria" id="EFI35250">
        <property type="protein sequence ID" value="EFI35250"/>
        <property type="gene ID" value="Dthio_PD2661"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50340EA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2162449at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="446" mass="50120" checksum="6E0BC1D916714D71" modified="2010-08-10" version="1">MHKVITGKHRAEANPAVRHDFYLQWQGRTLCFNKDSMAVTSSEISQSSSFCFVFVDFPQDEGPEQVYVQGDAKFAPILARRQAEQKGELGSDSVYHVYKVEKTGKNESEIVYHIIPRTLLEKAKSECYIPAGCVLMDWTGLLLSLLKKGGRKDQAIALHAESSILVVAGNSSRVKLVRRYPLFSGKKGGLGNVPGMIEHDLELCRREKGADFSEVQWIEICRASRQEELPRLGLPVRPWPLARYTHGKTSLWSALPFLLDAVEPSLALYGEKERYVRPLQVVEKWAWLILIAGAAALGYIGWMNHSVADRLNDRTATLEKDVDILENKVQSYVYHVKGTDEVDGAFELAGDLSRALAAPSPVQIWNSFFGSWPDDWQLIDILFSYDDGAIRIQAEGLVSSNPGQSARQSSRFRQQLTGYGFEIEQVDMDLKSKEARFVITASYPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL32</accession>
    <name>D6SL32_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="8" type="ORF">Dthio_PD2809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2809"/>
    <dbReference type="EnsemblBacteria" id="EFI35393">
        <property type="protein sequence ID" value="EFI35393"/>
        <property type="gene ID" value="Dthio_PD2809"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="12"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="369"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="469" mass="52695" checksum="0FA85F792BF20630" modified="2010-08-10" version="1">MKGQEKQKLWGGRFTSATSSLVEDFTQSLDFDRFLALHDLEGSRAHARMLAHAGIISEDELQQILSGLDRIENELEQDEFTWDPGLEDVHMNIEKRLTDLIGAPGQKLHTGRSRNDQVALDFRLYTAAALQEWQQVLKELIQALTRQAQAHRDTLIPGYTHLQPAQPVCLAQHLLAYARMFMRDHERIEDALPRVKVSPLGAAALAGTTYPLQPEQVAEHVGFEYVFKNSMDAVSDRDFVLEGLFIASMIMMHLSRLGEEIILWSNPGFGFIILPDAYSTGSSIMPQKKNPDVAELVRGKTGGVYGRLMALLTTMKALPLTYNRDMQEDKEPFIEAHRSVSSSLRVMAGMIAQTEFDRERMFGALKDGYLNATELADYLVARGMPFRQAHHITGRLVAFAEEKGLGLEDIDLDTFRSFSEIVDSDVYHVLDYQQAVKRRVTPGGTGPDSVDEQIRDIKGWMDRKNGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL50</accession>
    <name>D6SL50_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35411">
        <property type="protein sequence ID" value="EFI35411"/>
        <property type="gene ID" value="Dthio_PD2829"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="11528" checksum="332CBC71F9529C6E" modified="2010-08-10" version="1">MQGDGTSILMKLAEKVRNKYPQARVWLFGSHARGTATKESDLDICVVLPEVHPDDRLAVSDMAWEIGFDCDVHVSTIVVSERNFEEGPVSSSPLVETIRTEGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL70</accession>
    <name>D6SL70_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868563.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2851"/>
    <dbReference type="EnsemblBacteria" id="EFI35431">
        <property type="protein sequence ID" value="EFI35431"/>
        <property type="gene ID" value="Dthio_PD2851"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="203"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="281" mass="31940" checksum="F93DC5B2EAF6ED07" modified="2010-08-10" version="1">MKRLAVAVLLALFAHGLLLLTGDFQMKQRAGRDADEPKRISVSLEHYTPHEQGQTEEVSDHEFELPEEPDESEDPEESETEKKPPQEPVEEELPRQPEPEKKQPEEETRVKQAQALQEAEAAHEAESGPEQEEKTREADVQKPEDRTSALNASPVPQEPAGAPRMISQAALEAHEALDEYISEAGREDEELQMARPLYRENTPPEYPRRARQRNQQGKVILEVLVNSRGRVEEMEVAESSGYSILDRAAKDAVRDWVFEPGRRGEQSVDTRVRVPVRFELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL79</accession>
    <name>D6SL79_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2860"/>
    <dbReference type="EnsemblBacteria" id="EFI35440">
        <property type="protein sequence ID" value="EFI35440"/>
        <property type="gene ID" value="Dthio_PD2860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="67" mass="7608" checksum="E26541C565508A81" modified="2010-08-10" version="1">MIIMINKNKVAVSIQGVLVFSPWHSRQKRDSGTLMLTGGKLDKGGWLIIRYLQNHTALHKTPLYFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLB4</accession>
    <name>D6SLB4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2896"/>
    <dbReference type="EnsemblBacteria" id="EFI35475">
        <property type="protein sequence ID" value="EFI35475"/>
        <property type="gene ID" value="Dthio_PD2896"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="221"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="404"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="478"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="709"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="782"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="835"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="915"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1207" mass="136785" checksum="E42413AD8763A115" modified="2010-08-10" version="1">MSQRTSPPTDQGSLEQPVFENPQEILMNAPVGIFTTTPDGRYLSVNNTFARMHGYDSPRQLTDSITDIATQIYADPADRDELQGMLEKHGQVTNFECRLRHRSGRIFWVSENISVIKDKDGNITAYQGFNQDITERKQIEEAQQESEETINGIIDSSPFSIQMLDPQGYTVCTNPAFKRLFGAVPPPDYTIFNDPNFDRSGPEYDLLMRFAKGERISFSEHFYNTRRISSHLPDNPLWLRVEGFPLLDKAGKIKNLVLMHEDITEYKQAEEARIASEQKFKNLIEKCPASVMLLDHQGRVEFVNDWHIEKFANNKLGKEYFLGRSIHELPGLVSAGVDTEISRVFQGDDVELENVYFPEFAVGGSGWVNIRAVPVYQEGQVAGGILLRENITARKKMETALQQSQQKLRSLVENTQDVIYSHTPEGHFTYLSPQVSDLLGYEVQELLGKNFQDLVHPQDLPVVQRGLDNALKTDHNHGEVEYRLLHKDGHYRWFHVRVSFQRNSEGEIESVLGVARDITERKQAEELLRESEERTRHLNAVLKAYNQVNEVIFNARDVTSLLQEVCQALISTRGYYNAWIILLDKNQNVTHFGQAGLDDEFQELIDGFQYGKKPACALNVSTSPGLQVVMDPGTDCEGCPLAEQYSDRSGFSARLEVEGFVLGLITVSIPANLAGDLEEQDLFNSLAWTIAQGIQRIRLEKIRRSQRERLKNYERIISRINDGMAIVAPDYRYIIVNDAYQREFGKPREEIEGHTVEELVGKEVFYSKIKPRLDTAFAGEEVVSEDSFPGLDGVLKYKVMNYYPFYEKDGSVAGVVATGKDFTEQKKAEDALRESEELLRTVNETVGEGIVLKDASDRFVHWNKTASDIFGLDIEHARGQTPEVFDIKFIHEDGTEYAGDDFPSQHTLRTGEPCNNVIMGIKRNNQSTTWLKINTRPIFTPGEAKPYLVVVSFSDITERKHAEKILKSMNQQLQKSNVEKDELFSFVAHDLKAPIAGFLSLTEILNKYFDDFSMDELREMLSEMHKSSEGLHALLEDLLQWARVKKGMLVYTPESVCLNDLVTAGISLARSVADKKDIDLWNNVPRRMNLYADQKMIYSVIRNLLFNALKFTYQGGNVSIHAHKQGSMVKIMIHDDGMGMDQDTAARVFAIDKRKSVKGTDGEKGTGLGLALCKEFVEQHGGRIWIDSEPGQGTTVNFTAPYDQNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLB6</accession>
    <name>D6SLB6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Dthio_PD2898</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868609.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2898"/>
    <dbReference type="EnsemblBacteria" id="EFI35477">
        <property type="protein sequence ID" value="EFI35477"/>
        <property type="gene ID" value="Dthio_PD2898"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="14">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="636"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="883"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="15">
        <location>
            <begin position="1250"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1128"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="937"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1086"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="8">
        <location>
            <position position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI35477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1346" mass="150436" checksum="F0C0C3139EDDBE08" modified="2010-08-10" version="1">MSTRPTSLNDQDQSEQSVLPDAQDILDKATIGIFKTTLEGRFIYANRALAEIFGYSSPRDLIASVTDIATQLFADPVQWEEVRHLLDLHGIVKNYECRQIRRDGTVFWASGSIQAVTDAKGKASHFQGFVSDISDRKLAQDQWQSTFEALPDLIALVDNDHRILRVNNAMAEHLGLQPREIEGRFCYEVVHGLSAPPDFCPHSRTLRSRNEENAEVFEERLHGYFNVTTTPFRDAGGFILGSVHVARDITIQKHKHDVMQQAIEESRRSEAHLSSMFESARAILTTKDFPSAARHIFDSVSSLIGSSAGYVALLADDGRENELVFLESGGRPCYVDPALPMPIRGLRAQSYSLNAVVFENDFMNSQWMDFMPPGHVQLDNVLFAPLVLDEKTVGIIGLANKPGGFTEKDANAAKSFGDLAAIALRNSRNLEKLAENEQSLNYRLDLQRLLMDLAMDFLNVPTDNLNQATDRALMRLGQFTGTDRVYIFYYDYENHVMTNTHEWCAPGIEPQIDNLQKIPLALNPEHVRMHNEGRPFYLPDVSKLDNNDPFRLHLEFQDIQSLLAIPLMGPEGCLGFVGLDSVRSTRTWSDSEINLFALLAKLLVNAQLRQSREQDLKDAMEQAEIATQAKSEFLANMSHEIRTPMNGVIGMTDLLLDTELRPEQRSLAESIQSSGEALLALINDILDFSKIEAGRLELESVNFNLHYLLEDLASLMAVRADEKGLELICLPDPDVPAQVQGDPGRLRQILTNLVGNAIKFTHQGEVVVMVQKSEARSQKSDNSADDVLLLFTVQDTGIGVPEDKIDLLFNKFSQVDASTTRKFGGTGLGLAISRQLAEMMGGEVGVQSEYGRGCKFWFTARLTLQKKQEEPLPALPQDLHGEHILIVDDNETNLEILKKQLEAWGVEVEQASEGHEALLILDRVYSEGNYFAMAILDMHMPGMDGAELGRLIRNTDILKDLPLVMLTSLGRPGDAKIFEEQGFNAYLNKPVRQSELFDTLLTVLSSAGKAPGHSIITRHQAREIKRQQSELIKFKGHVLVAEDNPVNQKVAVGLLNKMGLSADIVDTGLKAVEALQNQSYDLVLMDVQMPEMDGLEATRRIRAAEDRNQRSEVRNQISEERNQSTGDRRWESQPLNPSTPEYHNPSIPKSFNPKIPQSLNPKIPIIAMTAGAMHQDRERCLDAGMDDYVTKPVNPGQLATVLSRWLKKENSFIPQQYGSIDNSACHFQKASNPSNPPFDYKSLLDRLEQDHELAREIANMYLQDIPAKIEELQKALEDKAVQKVLRAAHSIKGNSANTGCMAISAIAEMMESLAQSGELDKVANLMPELKRQFEICKTEIEKIQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLK8</accession>
    <name>D6SLK8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase associated with various cellular activities AAA_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2995"/>
    <dbReference type="EnsemblBacteria" id="EFI35569">
        <property type="protein sequence ID" value="EFI35569"/>
        <property type="gene ID" value="Dthio_PD2995"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="176" mass="19464" checksum="B22ABA97420D950C" modified="2010-08-10" version="1">MVAVFAFPVPRHRRLRSKRALSFPSCAAEPFERLLIALLADGHLLVEGAPGLAKTTAIKELARRIEGDFQRVQFTPDLLPGEEVIKHPAGVVITEVARWEGLPKEHGSIRFGERLLQVIQGDRPDSVSSTIPKTMIPGSTSICTGTSRLTQRPVFSTCVTPIAGSWRDLQQRFKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLM0</accession>
    <name>D6SLM0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868710.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3007"/>
    <dbReference type="EnsemblBacteria" id="EFI35581">
        <property type="protein sequence ID" value="EFI35581"/>
        <property type="gene ID" value="Dthio_PD3007"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="10763" checksum="A0C6EA97DFF84261" modified="2010-08-10" version="1">MHEKYTAIVRKSSSEYIAVCLELNLVAQGADLAEVERNLRAAIESYLEELSSSPETVVEPMPIQEFIEFLNDTELESSTQPSGKYILLEVHEAGSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLQ5</accession>
    <name>D6SLQ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="6">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">carA</name>
        <name evidence="8" type="ORF">Dthio_PD3045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868745.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3045"/>
    <dbReference type="EnsemblBacteria" id="EFI35616">
        <property type="protein sequence ID" value="EFI35616"/>
        <property type="gene ID" value="Dthio_PD3045"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="662268at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="373" mass="41332" checksum="5D0F1B7AB2B57685" modified="2010-08-10" version="1">MKALLALEDGTWFEGRSFTGMGEAEGEVIFNTGMTGYQEILTDPSYMGQMVCMTYPLMGNYGINPEDVESEKIQAAGFITRECCQIPSNWRSTQSLPDYLRGQKIMGMEGIDTRALTTHIRKYGAMRGVMSTTENDPGKLAQRALQLPHMEGLNLAEKAGCSKPFAWTEWGPIQADLNQDGSYDWPGSGGRVLVYDYGIKWNILRLLKAQGLELLVVPWNFGVQEAVKVAPDGVFLSNGPGDPAAMTKSIEIISGLLEKFPVAGICLGHQLLGLAMGASSFKLKFGHHGMNHPVKDMSTGKIEISSQNHGFCVNIDHLDFLEQTHINLNDNTLEGFRHKNRPVMAIQYHPEAASGPHDSRYFFSRYREMISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLT1</accession>
    <name>D6SLT1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868771.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3071"/>
    <dbReference type="EnsemblBacteria" id="EFI35642">
        <property type="protein sequence ID" value="EFI35642"/>
        <property type="gene ID" value="Dthio_PD3071"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335TV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1987498at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9278" checksum="108A91CDF4998973" modified="2010-08-10" version="1">MMPRLGEKYDVEIETVSKPMQEYHTDEYFEQDLPVAPAVMVGDEVVVEGANVDEYTVEEAICRHLGLQPPEKKGFLGRMFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLZ2</accession>
    <name>D6SLZ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868832.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3132"/>
    <dbReference type="EnsemblBacteria" id="EFI35703">
        <property type="protein sequence ID" value="EFI35703"/>
        <property type="gene ID" value="Dthio_PD3132"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503431E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="714510at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="355" mass="40827" checksum="824E409F41D40498" modified="2010-08-10" version="1">MFTLYQALFSAHIYFAQFWPQISEGFHDTPMLGTGFMVLGIVLGIVLFFILGYLAYSRLGSSTESQESNPFTVSSPEKIHEILDKAWAQNSRLELYFRTRGQHLSCLIQDLSGDKLVIEPPQHIKLKKSWLNRSVIVFFSVRIDRQKRVYYKFESSITGFPVINSEPVLQLAVPGVLNMEQKRVHLRLDPPLAYVKSMRVWQVLYNSDGSLPRDISSKAEPLAQYIPAESKPVLRLADLSGGGIRIKIAKSLLGSMEDFIKANPNLIIFLQLRDKPDQDSEVHNYYLVGRIRNYFTDQHGYYILGMQYEYSARLDPDTGDIVRWEKVDPEEGVEDVVNWVVQKHLQFYREKGVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM36</accession>
    <name>D6SM36_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868876.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3176"/>
    <dbReference type="EnsemblBacteria" id="EFI35747">
        <property type="protein sequence ID" value="EFI35747"/>
        <property type="gene ID" value="Dthio_PD3176"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11284" checksum="382B7E80FF84F490" modified="2010-08-10" version="1">MNQRLPNIHPGEILLEEFLLPLGISQNRLARSLSVPPRRINEIVHGKRSISADTAIRLARYFGNSEKFWLGLQEDFNLEEARKRLGDRLDLEVKTYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM50</accession>
    <name>D6SM50_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid pRiA4b ORF-3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3191"/>
    <dbReference type="EnsemblBacteria" id="EFI35761">
        <property type="protein sequence ID" value="EFI35761"/>
        <property type="gene ID" value="Dthio_PD3191"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878">
        <property type="entry name" value="PTHR41878"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="207" mass="24579" checksum="1FE855FE0A675870" modified="2010-08-10" version="1">MSQLIYQFYIRLQEIEPPIWRRIQVPDTYTFWGLHVAIQDAMGWLDYHLHAFRFRPKHKRDVIEIGIPSEKWDDLETLPGWDIKLDSYLHQPGQWFEYEYDFGDGWMHDALFEGLLVKEKGSKYPKCLGGERACPPEDCGGVRGYYQLLDILNDPDHEDHQEMVAWLKGHLKKYYPYNPDMSFALRKCAFPVPQPDGKKPFWKNDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM89</accession>
    <name>D6SM89_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868929.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3235"/>
    <dbReference type="EnsemblBacteria" id="EFI35800">
        <property type="protein sequence ID" value="EFI35800"/>
        <property type="gene ID" value="Dthio_PD3235"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="74"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15051" checksum="193D72867C8E1E32" modified="2010-08-10" version="1">MLLQDILDSKLAQVVKVHQDETVAETIKLLEEMNVSGVFVVDDNDRLRGIFTEKDVVTCFATGVQASDTRVREVKRGDLVTFEPSTEVSLALATASKNKMRHLPIVQGDEIKGMITYRDLVSHVLPEICFMAEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMB4</accession>
    <name>D6SMB4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868954.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3261"/>
    <dbReference type="EnsemblBacteria" id="EFI35825">
        <property type="protein sequence ID" value="EFI35825"/>
        <property type="gene ID" value="Dthio_PD3261"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1280736at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016545">
        <property type="entry name" value="UCP009120_prtse"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009120">
        <property type="entry name" value="UCP009120_prtse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="261" mass="29351" checksum="B8ED24C8AA94C949" modified="2010-08-10" version="1">MTFCLGIAVEQGLVGIADTRITSGKELTSAPKITCYNFGNGNGAFFIMSSGLRSIRDKVIIYFDEELGQREEPFDRIYKAVNAISRHIRVVAEEDGAFLKQNGLSFNMHMLVGGQLKNDAAHQLFLVYPEGNWVIITPGTPYHIIGESGYGKPVLDRTLKYTDDLSFALKVGCLAFDSTRISASDVDFPVDVILYYRNAGNMVTHRYEKDELSEISTWWQEKLRSLVHELPSEWVEDIAARLTKVNPEKRSPIEPPDGRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMC6</accession>
    <name>D6SMC6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein adenylyltransferase SelO</fullName>
            <ecNumber evidence="9">2.7.7.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">selO</name>
        <name evidence="10" type="ORF">Dthio_PD3274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:58120"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15073"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:142516"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.n1" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868966.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35837">
        <property type="protein sequence ID" value="EFI35837"/>
        <property type="gene ID" value="Dthio_PD3274"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="130048at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PTHR32057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="485" mass="54899" checksum="B9AEB2FA781A7B1C" modified="2010-08-10" version="1">MFRFDNSYAGLPEDFYARVAAARVPAPRLISWNSDLADELGWENLQYSEEEIADCFSGNRQLPGADPIALAYAGHQFGSFVPSLGDGRALLLGEVVNSRGQRFDLQLKGSGRTPFSRGGDGKAPLGPVLREYLVSEAMHHLGLPTSRSLAAVLTGEQVYRDKALPGAVLTRVASSHIRIGTFEYFASRQDHESLKTLLDYTIQRHYPEIKGEPDAPVLFLAKVGRLQAELVSGWMALGFIHGVMNTDNMSVAGETIDYGPCAFMDEFSHDRVYSFIDQGGRYAYSNQMPIVLWNLSRLGECLLPLMPQDSNEAVRILENELMSTQAFLERRAHEKMCCKLGIFDHPGEQDKELVKDWLHYLEREKLDYTQSFRNLAELVNSGSYPGWFSPGNELKDFCDRWRRRIMQQGLDPEEIKKMMNEHNPVFIPRNHKIEEIIEAANQGDFSLFHEMNELLKNPYLEQEGFKSYTLPPRPEEVVANTFCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMI0</accession>
    <name>D6SMI0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK domain protein ATP-grasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869020.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3330"/>
    <dbReference type="EnsemblBacteria" id="EFI35891">
        <property type="protein sequence ID" value="EFI35891"/>
        <property type="gene ID" value="Dthio_PD3330"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027592">
        <property type="entry name" value="ATP-grasp_GAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04356">
        <property type="entry name" value="grasp_GAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="112"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="299" mass="33298" checksum="9F5C05C460064CCD" modified="2010-08-10" version="1">MNASKKDRKIAVIGNPGSWSTEKLADALENKTGFRCVVDISSVIFDINHKTLFYGDLDLATLDGLAIKKIGPVYSPDMYNRLEMLRFFCSMEIPVFSRPEMIMQAVNRLSCTVNLQIGNIPMPPTVVTEDMELACDTVRRFKKAVFKPLFSSKARGMLVVEEGYHCRSAIAEFQASGNRTMYIQKMVSIPGRDLGVAFMGGEYIGTYARRKGDSWNTCTSSGGKYERCEPDPEIISLAHSAQALFNLDFTCVDVVETDQGAMVFEVSAFGGFRGLYQAWGMDAADMYAGYILDNLKYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMK4</accession>
    <name>D6SMK4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD3355</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869043.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3355"/>
    <dbReference type="EnsemblBacteria" id="EFI35915">
        <property type="protein sequence ID" value="EFI35915"/>
        <property type="gene ID" value="Dthio_PD3355"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="136"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="209"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="262"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="337"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="407"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="673"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="826"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="13">
        <location>
            <begin position="1085"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="896"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="922"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="727"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="875"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1175" mass="130494" checksum="08A7E8E1E8EA410A" modified="2010-08-10" version="1">MSEKTLNTILVVDDTQTIRHITKKTLEADNYVVLAASNGPEALSIAADKIPDLILLDVMMPDMDGFEVCSRLKADICTRDIPVVFITASGNKEHEVKGLDLGAEDFVHKPFHEGVLLARVGQILRRLQAEEQLRTSRESHRMLLDSIETQVWHLTDEHTYGAVNRAHADFFGFSPSEIANRDIDQFLPEGMVAAIRKGNREVFSRKEQIHIEEWVSNASGEPRLLSITKTPKIDEQGNVDYVVCSAEDMTAQWKATEKLKVSEEKLSSILNNMKDVVWSISWPDLRHLYLSPSSEKLYGISAHEFYENPTLFKDVTHPEDRHLTKKAVEQLLEEGEAVRECRIIRPDGSIVWINDTSKMIYDDNQQPARVDGVTRDVTELVKARQDLIQAKEHAEEATRAKSDFLANMSHEIRTPMNGVIGMTGLLLDTDLDSEQQHYARTVRSSAESLLTVINDILDFSKIEAGRLDIETVDFDLEAMLRDFSGMMAVKAEEKGLELICSMDPNVPSMVRGDSGRLRQILMNLVGNAVKFTEHGEVEIRVSKSEVVDQRSEVSDQPANRLSHEQTGIKDQYGDSRIVELCFQIRDTGIGIPQDKQDSLFESFSQVDASTTRKFGGTGLGLAISRQLAEMMGGTAGLESVEDQGSTFWFTVRLGVQDEQQQERPVPACLQGVRTLIVDDNSTNREILRVRFGSWGMRPGEAANGSAALSMLHQAKAENDPFVLAVLDMQMPDMDGETLGRNIKEDGQLKDTRLIMMSSATGQTGDSRRLHETGFDSILNKPVLPSELYASLEKILARTGAADLPAGHTEPEKIRQGYPDFSGTKARILVAEDNMVNQQVALGILKKMGLRADAVANGQEALHALENIPYDLVLMDVQMPEMGGLEATRRIRSMEHGTPVKPLSTTGSPLGCFTGQAGGMEHGAEDKGQRSEVRDQRLESESQNTSVPESLNPSIPQFLNSSIPEFRIPIIAMTAGAMQEDRERCIEAGMDDYTAKPVNPDELARVLEKWLSKERNQRTEDRSHKSEVSDQGTGGRHQAEGSGQGEEEGDLGTGEAAETKQEPSKAFVCTRPVFDQEDFLTRIGHDSDMAEHILNIYMESLPKNIKLLKNFIAQGQNEEATRQAHSIKGNSGNIGGLAMAEIAGMMEEAGHCGKLEQMKELMHELERQFDICMAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMM1</accession>
    <name>D6SMM1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869060.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3374"/>
    <dbReference type="EnsemblBacteria" id="EFI35932">
        <property type="protein sequence ID" value="EFI35932"/>
        <property type="gene ID" value="Dthio_PD3374"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1455618at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="27454" checksum="1BD152FFC9E190F3" modified="2010-08-10" version="1">MDYLLICIVAMGVSGLTLFSGFGLGTLLLPAFVLFFPVQAAVAMTAVVHLANNLFKLFLIGNKADSATLLRFGLPALAAGFAGAWLLLSLADLEPVYSYELWGRHMEVYPVNLVIGLLMGFFAMLELYSPLNRLQISPVYLPLGGVLSGFFGGLSGHQGAFRSAFLLKSGLDKEAFVGTGVVIAVLVDVSRITVYSGMVHSPEIRENLPLIAAAMLAAFAGAFIGRRVLSKITFRTVQLIVGIMLMLVSILLILGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMM3</accession>
    <name>D6SMM3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Smr protein/MutS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869062.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3376"/>
    <dbReference type="EnsemblBacteria" id="EFI35934">
        <property type="protein sequence ID" value="EFI35934"/>
        <property type="gene ID" value="Dthio_PD3376"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1888882at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="10665" checksum="B5E8361821560C61" modified="2010-08-10" version="1">MSSRRLSLDLHPIFNKGREIDAALENAFQEARQKKAKELEIICGKGTGQLKKRVLRFLDRDDIKSTYHRINRDKDNSGRVFVYFRWQRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMP0</accession>
    <name>D6SMP0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dnaJ</name>
        <name evidence="12" type="ORF">Dthio_PD3393</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869079.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3393"/>
    <dbReference type="EnsemblBacteria" id="EFI35951">
        <property type="protein sequence ID" value="EFI35951"/>
        <property type="gene ID" value="Dthio_PD3393"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="11">
        <location>
            <begin position="132"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="145"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="162"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="9">
        <location>
            <begin position="132"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="367" mass="40701" checksum="31A9830AA2CC395B" modified="2010-08-10" version="1">MAEKRDYYEVLGVSREASQEEIKKAYRKMAFKYHPDRNPDDPEAETMFKDASEAYEVLSDPEKRQRYDHLGHAGMEGNGFHGFRSTDDIFDSFSDIFGDFFGFGGRRSGPRARAGADLRYNLTVSFREAAKGTEVDLELPKREKCDRCTGQGSEPGHSAETCKHCGGSGQVHRTQGFFRVAMPCAVCQGQGMLITNPCKKCKGLGVIQVNKHIKVRVPAGVDNGSRLRLRGEGEPGEHGGPAGDLYVVIFVEEDDTFKRQGQDLVTQVDITFVQAALGGKVEVPTLDEPISMEIPKGTQSGKVFQLSGMGLPYPGGTQRGDLLVQVQVKTPTKLSKRQEELLQEFENLEKEKAGHKVKRFFKKVMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMR6</accession>
    <name>D6SMR6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869105.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3419"/>
    <dbReference type="EnsemblBacteria" id="EFI35977">
        <property type="protein sequence ID" value="EFI35977"/>
        <property type="gene ID" value="Dthio_PD3419"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="168" mass="19149" checksum="F97FDF1E310EFCB1" modified="2010-08-10" version="1">MQVLETIYNRRSIRKFTQEDVSKEDVRRILDAGRWAPSGLNNQPWRFLVLARGDERKNGLEECTKYSHIVRAANVLITVFLDRQAKYHHEKDCQGAGACVQNMLLAAHALGLGAVWLGEIINQESQVHRVLCTDPEQLELMAVVALGHPDQKGSSQRRDLKELMLEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMR8</accession>
    <name>D6SMR8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869107.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3421"/>
    <dbReference type="EnsemblBacteria" id="EFI35979">
        <property type="protein sequence ID" value="EFI35979"/>
        <property type="gene ID" value="Dthio_PD3421"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017150">
        <property type="entry name" value="Pept_M20_glutamate_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037238">
        <property type="entry name" value="Carboxypeptidase_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="181"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="41261" checksum="FCBE1D305E2DA3FC" modified="2010-08-10" version="1">MIQKIAEDIYSRQQEMLDLLRQLVLIQSGSHNKEGLDRMAETMAGILAGTGMDSRVVPFTHCGNMVIARTPKAGEQKGLLLVGHMDTVFAADTSFDWFQEDETCAYGPGVLDMKGGLVVGVFALKALARFGMLQDLAVTFLCNSDEEVGSPYSRGLIGELSQKNKMALVLEGGGLDGELVVGRKGKIGLQVQVWGQGGHAGNFSGSSKPSAVVEAAHKVLSLEELNSPPRIQVNVGRVQGGTRPNCIPEKALLEVDIRYQDTGEEKVLQDRIQSILKTSQVPGTSCTWEVVSSRPPMPRGKQGEALYGLAREAAEELGIAIGQEVRGGVSDANFIAAMGLPVLDGLGPLGDHDHSPSEYILKNSLTQRCALTAACILKALHQDKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMV0</accession>
    <name>D6SMV0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="4 6">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="4 6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869139.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3453"/>
    <dbReference type="EnsemblBacteria" id="EFI36011">
        <property type="protein sequence ID" value="EFI36011"/>
        <property type="gene ID" value="Dthio_PD3453"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="7">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="31599" checksum="A7C7F435546EA5F5" modified="2010-08-10" version="1">MNSPTVLIAGGRTGLLGQALVQVMQGEGLKALAPGRKELDLFDARQVEDTIRKNNIDLVANAVAYTGVDQAEEDQDEAYRLNRDLPGILGQVCRENNVGLVHYSTDYVFDGKKNTPYSTDDTPRPLCVYGRSKLAGEELLMQSPWDGLLILRSAWLFGPFKTNFVSKMIQMAESGRPLSVIHDQTGSPTCTLDLARYSLELVKKQTSGLFHVVNKGQASWCELASEALMCAGLSSRVNPVSSGEYPQKARRPSYSVLDTSKFSMVTGITPRPWVHALREYVFQVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMX5</accession>
    <name>D6SMX5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3478"/>
    <dbReference type="EnsemblBacteria" id="EFI36036">
        <property type="protein sequence ID" value="EFI36036"/>
        <property type="gene ID" value="Dthio_PD3478"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="73"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="335" mass="37357" checksum="8D5D33741D413E37" modified="2010-08-10" version="1">MFKQSWNRLTRRGFLSRVSIMAAGWKLLPFMSGNFVHAENNSEVGLIKTEDRKEAVRRAFKLGSPPSMQGKKVLIKPNFNTADPAPGSTHNDTLSTMIDEVRQRGAREIIIGERSGPPDTREVMEEKGIFDLAEKEGVQVINFDQLEDHELVHFEDKELHWKDGFHVPRILYEVDHILACGCLKTHQFNGVFTMALKLAVGIIPREGTDYMSQLHGSEDMRKMIAEINLAYHPDMYIIDGIDAFVSGGPATGEKVRAGITLCARDPVAIDAVGVSILKKLGSTPDIMDKPVFQQEQIARATEIGLGVSGPEMIRLLSDDPAGEDYIQSLHEYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMY1</accession>
    <name>D6SMY1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3485"/>
    <dbReference type="EnsemblBacteria" id="EFI36042">
        <property type="protein sequence ID" value="EFI36042"/>
        <property type="gene ID" value="Dthio_PD3485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="39" mass="4058" checksum="941949E6EA33F633" modified="2010-08-10" version="1">MIQAVSALLPARHAAHPVAALREYRVVLTFLVIGGASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMY3</accession>
    <name>D6SMY3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869172.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3487"/>
    <dbReference type="EnsemblBacteria" id="EFI36044">
        <property type="protein sequence ID" value="EFI36044"/>
        <property type="gene ID" value="Dthio_PD3487"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="317" mass="35579" checksum="27FACF55471CA10A" modified="2010-08-10" version="1">MGEAASLLILLIAITFVVLIVKGLVIVPQKHAMVIERLGRYHRTIEAGLNLIIPVVDRHRPITIVRYENEQKLIRTEKRIDLREVVLDFPKQQVITKDNVGVQIDGVLYYQIMDAQSAIYGAENLVLAIQTLAQTSLRSEIGRMELDQIFESRQQINDRLQATMDEAGNKWGVKVNRVEIRDIDVPDDIRSAMNKQMAAERARRAHVREAEGYKQAEILKAEGDKEAEIQRAEGEKQAISLRAEGEKKAINLVLQAAEQTGASIDPKDVMRYLIAQGYIEALPNVAKQGDRVFLPLESTSLMGSIATIRELFSTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMY9</accession>
    <name>D6SMY9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-hairpin-helix DNA-binding class 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869178.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3493"/>
    <dbReference type="EnsemblBacteria" id="EFI36050">
        <property type="protein sequence ID" value="EFI36050"/>
        <property type="gene ID" value="Dthio_PD3493"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1571770at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="417" mass="47063" checksum="FBA589CC10D61DDD" modified="2010-08-10" version="1">MGFLNIGRKDEYGKQRRIEHRGKYLRASRTGGVALRAQAKAMGANLTANTNRGFRVSTTPLKNTQVALQNGRFVLRGRYSHGPFQFNLSKTGVTASTRNRLGTFNWIKPQRSSAKLFGVQFRGRKAVNLQVLYMLFAAVAAVCTLLFRLFVRLLEVLVLLPGIIYRATLASPYASSMLMRRYRNWRLSRTIARLERYTGREMDSWQVEELAAGAVLILAAWGRGNKTTEMASVLEQAIAEHTQEGPLQRSLQYLPDTSLRLEKYTEEFKGDPVHHLALMAMLASRLARKISEDELPEVLLEADEITLNDGPRTMLQERMLEVFGDFAGLQLFEEDSVALAEESYPAQAPDREFGHVESKLDLNSASLEELQALPHIGEERAKAIAARRPFFDMEELKEIDGIGPQRLESIRAYATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNB9</accession>
    <name>D6SNB9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869573.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1596"/>
    <dbReference type="EnsemblBacteria" id="EFI34245">
        <property type="protein sequence ID" value="EFI34245"/>
        <property type="gene ID" value="Dthio_PD1596"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087988" evidence="3">
        <location>
            <begin position="24"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="454" mass="52670" checksum="1ACBE0905037EE03" modified="2010-08-10" version="1">MDIKRVVLAGFVSLFLMAGPVQAGDETHNSGDSLVLDMKDAVKMGLDRSHRVQAHDYGIKRSESEVKSVRGQFFPQLSAGAGYTYLDSLSARGPTDQDYLDQQQYQWNLRAVQTVFAGMTILSSYQQAQIEKEISELEKENTERELIREIQHHFLELLKAREDRRALDSSVERLEVGLEASESFYERQLVPYVDVLQAGVELEEARQDLSQAKNEEQIQKTQLNALLGFGYDYLIGYEGDLEEIPLDIFFETREVIDIAMEQRTDLMFIRKNMAVTEQERRIARGQKMPRVNLEFVYTDRKRDYDEPQQTMEGPMDRDQRNRHWTAGASIEWEFFSGGQQYYQHEAMGYEIRRLVQTLKETESSIVTEVRTAQMRLDEARDRLVSTRKALNAAQENYDMQEHRYKQRVGTITDLLTAQEHLTEAETRNNQALMDFQQALSELYFAIGERNYGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNG7</accession>
    <name>D6SNG7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">Dthio_PD1644</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869621.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1644"/>
    <dbReference type="EnsemblBacteria" id="EFI34293">
        <property type="protein sequence ID" value="EFI34293"/>
        <property type="gene ID" value="Dthio_PD1644"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="341" mass="37450" checksum="D4477DB3B4FDE53D" modified="2010-08-10" version="1">MTKDPVVAVAGATGAVGREMLRILAERDFPAKEIIPLASSRSAGSKIEYKDSKLIVQELTEDSFKGVDLAIFSAGGGTSEKYAPIAAKSGCVVVDNSSFWRMDPDVPLVVPEVNPEDLEKHQGIIANPNCSTIQMVVVLKPLHDVSRIKRVVVSTYQAVSGSGQKAVHELETQVKQLFNMEEVTPSVYPYQIAFNCIPHLDAFLDNGYTKEEMKMVNETVKIMGDESVKVTATTVRVPVFFGHSESLNVQTESRISREDARAILTQAPGIRVMDNPEEKIYPMPLFAAGKDETFVGRIREDQSTENALDMWVVADNIRKGAALNAVQIAEFLLVKDLVRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNK7</accession>
    <name>D6SNK7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1684"/>
    <dbReference type="EnsemblBacteria" id="EFI34333">
        <property type="protein sequence ID" value="EFI34333"/>
        <property type="gene ID" value="Dthio_PD1684"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="177"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="358" mass="39876" checksum="93E77F96C0B052AE" modified="2010-08-10" version="1">MSALKILQINTEKGWRGGERQTLFTMKGLARAGQDVRLVCLRDSPLARRARAESVAVSEVKTQAGALRFLATQGRDFDILHAQTGRGQSLAVMTRPLHGRRIVYTRRVDFVPRGTLSLLKYHYTHQTVAISQAIKDIMEGTLPGRQVEVIPSCLDTTVSLRSPSAEALSLQKRLAPRKIIACAAALVPHKDPLTLVRAAARLREERAPDFVIVHFGRGPLEAEVRREISRLGLKRSYLLMGFEQDLESFFPVFDLFVMSSQEEGLGSSVLDAFRYRVPVVSTEAGGLKDLVSGRGLICPVGDPVCLARSMARVLRSPESLQDMTSKARAYVVREHSLEEMTRRYIRLYRQVLNPAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNL3</accession>
    <name>D6SNL3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869667.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1690"/>
    <dbReference type="EnsemblBacteria" id="EFI34339">
        <property type="protein sequence ID" value="EFI34339"/>
        <property type="gene ID" value="Dthio_PD1690"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="8631" checksum="2459563053A08C98" modified="2010-08-10" version="1">MQSIFRISSKGQVIIPAELRKKHQLEPGAEIQFLEYGDIICLVPVKGDPVVEAYGSLGSEPSLAEELARERTQDFADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNN3</accession>
    <name>D6SNN3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Formate dehydrogenase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869687.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1710"/>
    <dbReference type="EnsemblBacteria" id="EFI34359">
        <property type="protein sequence ID" value="EFI34359"/>
        <property type="gene ID" value="Dthio_PD1710"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="83812at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047111">
        <property type="term" value="F:formate dehydrogenase (cytochrome-c-553) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006443">
        <property type="entry name" value="Formate-DH-alph_fdnG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01553">
        <property type="entry name" value="formate-DH-alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113560" checksum="604B805E4AC08105" modified="2010-08-10" version="1">MILNRRGFIKLSVAAGSFLAFAGLGFNMKPTTAKAQLLRINWGRETTSICCYCSVGCGLLVHTSKEGQGRTINVEGDPDHPISEGSLCAKGASVYQLAENENRLTKVLYRAPYTDKWVEAPWDWAITRIARKVKEARDETFVKTNDQGQVVNRTDGIAHVGSAALDNEECWYLQALMRSLGLVYIEHQARLCHSSSVPSLAESYGRGAMTNHYTDLMNSDCILMMGGNPAECHPVTFKWIMKAKENGATLISVDPRYNRSSSKADIFAPMRSGTDTPFLLGMVKYILDNDLYFKDYVVNYTNAAFLVNPDFYFDPEEGLFSGFQKKSETNFAVFGSYDRDSWSFQKDNDGIPKRDTSLQDPNCVFQLLKKHVERYTLDRVSETTGTPRDKLEEVYKAFAATGAPDKSGTNTYAMGWTQHTIAVQLIRSMAMIQLLLGNVGNAGGGVNALRGESNVQGSTDSALLYHIIPAYNPTPRASWPTLEDYNKANTPVSHDPKSANWWQNRPKYIASLLKAMYPDKEPSESYNYMPRLDAGQDCSWLVMFDHMHQGKFKGLFAWGMNPAVSGADTNKTREALSKLDWLVNVNIFHNETGSFWHGPGMDPGRIKTEVFMLPAAVFYEKEGSITNSGRWAQWRYEGPKPLGGSKRDGDMMVMLARRLKALYQEEGGEFPEPIANFNLDNIVTDGKFDVEKMARLHNGYFLRDKTIDGTTYKAGTQVPSFALLQDDGSTACGNWLYCGSFTEDGNLMARRDKTQTDMQANIALFPNWSWAWPVNRRVLYNRASVDKNGRPYAPDKAVIKWQDNQWVGDVPDGGWGPSEKHPFIMTTEGYGRLFGPGLVDGPFPEHYEPLECPFEEQPFSKQLHNPVALHFEGEKRAVCDPRYPFVGTTYRVTEHWQSGVMTRWTPWLLECMPELFAEIDPELAKLREINNGDKVIVENPRGRVKAVAIVSHRLAPYKVMGQNLHMVGLPWHYGWLQPKDSGDAANLLTPAVGDANTGIPETKAFMVNIRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNN6</accession>
    <name>D6SNN6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nickel-dependent hydrogenase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869690.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1713"/>
    <dbReference type="EnsemblBacteria" id="EFI34362">
        <property type="protein sequence ID" value="EFI34362"/>
        <property type="gene ID" value="Dthio_PD1713"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1967820at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="488" mass="54211" checksum="466D046FE89BBAC6" modified="2010-08-10" version="1">MKKIEINPMTRLEGHGKIAIFLDENGNVDDAFFQTVEFRGYEKFLQGMPIEEVPRTVSTVCGVCRAVHFLCSMKASDDVYGVAPPSTGRKLRELFYSAHTVEDHTAVLYALGFPDFVVGPDASPAERNLVGLIKAVGAETGKLVLQKRGLAVKIFELLGGKPNHPVAALPGGWSKRINEEERAQIEKWAEELVELGKLTLQVFDDVVLKNPKYMELVTGEMYRVEVGNMATVDEQNRFALYDGTQKAIDAQGNVVGTFRGKEYLDFISERVLPWSYLKFPYNKKLGGWDGIKSGPDTNIYCVGPLARMNVVDSMSTPLAQEHFEKFHDTFGAWPVHYIQAYHWARAIEVLAAAEKCLELSRDPEITGSDIWNQPSSCTGEGVGILEANRGTLVHHYITDDQGIVQNANLIVSTTHNNAPINLAVKTAARHFIQDGNVSEALLNHVEMAFRPYDLCLACATHTVTGGQQPVEVNIYKNSGELYKQMKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNQ7</accession>
    <name>D6SNQ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869711.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1735"/>
    <dbReference type="EnsemblBacteria" id="EFI34383">
        <property type="protein sequence ID" value="EFI34383"/>
        <property type="gene ID" value="Dthio_PD1735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019284">
        <property type="entry name" value="RP532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10097">
        <property type="entry name" value="DUF2335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14440" checksum="4B128B156EA36CDA" modified="2010-08-10" version="1">MSEESKSQNKKDNSPSSSSQKDDPIRNAHAQEEADTDQVLRDIEKMTPAKRKAVFSAIQYSGPLPPAEQLQAYEEILPGAADRIIKMAEDQAFHRRTQEEKMGFLYMEADKKDRHQKKAKTNHPGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNR9</accession>
    <name>D6SNR9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="10" type="ORF">Dthio_PD1748</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1748"/>
    <dbReference type="EnsemblBacteria" id="EFI34395">
        <property type="protein sequence ID" value="EFI34395"/>
        <property type="gene ID" value="Dthio_PD1748"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019857">
        <property type="entry name" value="CRISPR-assoc_Cas1_YPEST-subtyp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03637">
        <property type="entry name" value="cas1_YPEST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="313" mass="35617" checksum="D5B705BCD7E4BEA1" modified="2010-08-10" version="1">MQNKQSNRRPMAVMLSKRANVFYFEHVRIMQKKDRVVYLTETGGGDVLQFVNIPDKNTAFVLMGKGSSITDAAARKLAESNVLIGFAGSGGSPLFGAMDFTFLLPQDEYRPTEYAQNWMKMWLDEEKRLSLAKKFLEKRVEWGEKHWPSLSLNWPREASDILRESIHSAEQANDLLLSEAKFAKSLYACLASRYKIDEFTRDPGQKKGETKAQLINSYLDHGNYIAYGYAAVTLHGLGIPFFLPVLHGKTRRGALVFDVADLFKDWVVMPVAFDCGSRKVKNSEFRALIIQQAHERSLLDMLFQFLSDLAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNU5</accession>
    <name>D6SNU5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869743.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1779"/>
    <dbReference type="EnsemblBacteria" id="EFI34421">
        <property type="protein sequence ID" value="EFI34421"/>
        <property type="gene ID" value="Dthio_PD1779"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="211" mass="22968" checksum="F0F7FD3675D610A0" modified="2010-08-10" version="1">MEIIDLSHRIEPGMPVYPGTDAPVLERPFDLDKDGFAETKLSLMSHTGTHMDAPAHILDRGKTLDRMPISAFYGQGICIDATPEQMEIAAQDLTPYEDMIKTADFVLFRTGWSRLWGTAGYFEGYPVLSPEAAHRLSESGLKGVGFDTISADGPADTSFLIHGILLGKDMIIIENLANLDQLPRAGFSIACFPLHFVEADGSPVRAVAFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNV2</accession>
    <name>D6SNV2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869750.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1786"/>
    <dbReference type="EnsemblBacteria" id="EFI34428">
        <property type="protein sequence ID" value="EFI34428"/>
        <property type="gene ID" value="Dthio_PD1786"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1265861at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="131"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="506" mass="57124" checksum="5E28CFE32CD68B78" modified="2010-08-10" version="1">MSKETVRDKTDPGISPAPDRDKQNCWEVMQCGRGPDQGLDQEHICPAAREKRLDGVHGGRNAGRSCWVVAGTCCGGNVQGVFAQTITKCRHCMFYQQVVSEEKESFLDMVSLFQKLIEAGKKLGRIKRRGLIVGGSGLIGGTLMHYFKSQHGDAYEILAPNSKRLSLREPEDIKSYLETYRPDFIVNCAIPPLDGGPQLAYEVNYLGSINLARAAMALRVPFIHFSSAALQPMGENVAEDEYLPLSTSMPFYPRSKLMAEMTLKHLHETRGLDCTVIRLGVVYGKHDHKIQGFQRLLFSIATQSMMFLLTRPGVRHSYTHTEKIAPFVHHVLQNREEFTGQTYHFVDPEPVELSRLMLAVKNALGVKKPRAVHVPYSMASLGGYSLKLFLRMLRPLGYDGRLPQEVMFMDKFYQSQILSVDKLKKSSFGVPDPEVTVYSELPGIVRYYVARWQHYNLIPTVDRDLLQTAPGTKTFQSAPQDLLEGLHSGRYEYLADFEPLRDQDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP44</accession>
    <name>D6SP44_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS66 Orf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1886"/>
    <dbReference type="EnsemblBacteria" id="EFI34520">
        <property type="protein sequence ID" value="EFI34520"/>
        <property type="gene ID" value="Dthio_PD1886"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="13567" checksum="381580BDDD5EBD52" modified="2010-08-10" version="1">MIAVSQARVYLVTGHTDMRKAIDGLSIMVQAQLEHDPFSGHLFVFCNRQRTIIKILYWDTSGFCLWQKRLEKQSFKWPASKQEVMELDARQLVWLLDGLDPVQVRGHKELKFSTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP90</accession>
    <name>D6SP90_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869886.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1938"/>
    <dbReference type="EnsemblBacteria" id="EFI34566">
        <property type="protein sequence ID" value="EFI34566"/>
        <property type="gene ID" value="Dthio_PD1938"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="610" mass="70120" checksum="51A9C5E5D3A4CCE2" modified="2010-08-10" version="1">MFDFLYHKNTAKQRYDLQDVQSPQLLRDLYPYNHVPRIAFDDSFILPRPPEEIFITDTTFRDGQQARPPFTVEQIADIYEYLHRLGGHSGLIRQSEFFLYSDKDKKAVEACLEKGHRYPEITGWIRANKEDLKLVKDMGLKETGMLTSVSDYHIFLKLGKTRQQAMDDYLELVEAALDWDIIPRCHFEDITRADIYGFCIPYAQKLMELSQQKGLPVKIRLCDTMGYGVPYPGSALPRSVAKIVRAFTHEAKVPPEALEWHGHNDFHKAFINGTTAWLYGCSAVNSTLFGIGERTGNAPLEALVIEYISLTSDDDAAYTPVITELARYFHKNLGAEIPANYPFAGRDFNATSAGIHVDGLMKNEEIYNIFDTEQILHRSIPIIITDKTGKAGVAYWINHYLDLSDDQKVDKRHPAVGKIYEKIRKSYNQGRTTNFSHEEMDQLVRRYLPELFSSSFDQLKELAHRVLKKIIQDLAAEPEMASLDIDSINSKMQEFLKEYPFIQYMYLTDINGCLMTWNVSDIGDLSKYRQVEPGINLSDREWFIRPVKTGKMHITDFYKSHFTGKLCLTASIPVFSETDEILAVLGADIRFDELVKIQEDFAFEQNLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPA6</accession>
    <name>D6SPA6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Outer membrane protein assembly factor BamA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bamA</name>
        <name evidence="8" type="ORF">Dthio_PD1954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the Bam complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BamA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869902.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1954"/>
    <dbReference type="EnsemblBacteria" id="EFI34582">
        <property type="protein sequence ID" value="EFI34582"/>
        <property type="gene ID" value="Dthio_PD1954"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258122at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01430">
        <property type="entry name" value="OM_assembly_BamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03303">
        <property type="entry name" value="OM_YaeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="164"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="236"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="316"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="490"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="890" mass="101923" checksum="7F9573BCB33D9B6C" modified="2010-08-10" version="1">MSLINNSLLQRVLVFLPFFLLMLAAGTSHAGQKQILVLPFEINAPEELEYLQTGLPSMLTSSLRDKGLDVVEPELGQTLITREEVSYLDVEKARRLALLGDGRFALYGTFNAVDEYISLDARLVDGYGERETVPFYIVKEGVINILPAVEELAEKVYQEMLREERIASIDIEGVDILDPDVVLLRLQVQEGDMYDPEKLNRELRNIFDLGYFDDVQFHVEDTPQGKEVTIVVEEKPLIQNINISGADDISESDVREVLTTRTGSVVNPQIISEDLGRIRELYRGKGYYNATVDYSISEIDEREANLNINIDEGNRLFIRGIEIRGAEEISERTLRGEMELKRRGIFSWLTGRGVLREELLDRDVAALEAFYADKGYIDARVGQPDVDYEEDGIYLTFHVEEGHRYKMGEVSFQGDLLVSEDELKKLTILDDLGEEGEYFSRSSMQKDTQNLADFYTDYGYAFAEADVNMQVDEDEKKVDVIYNLSKGEKIYIGRVLIEGNTRTRDNVIRREMRLTDGDLFRGSDLRRSTERLQRLDYFEQVDIQPVPTEDDNVLDLVTQVEEKPTGMLSAGAGYSSYDRVFFTGMIQQRNLFGKGYQLSFSGSFGARTTRFDLDFWNPRVRDSNLGMGADLYWIDEEYFTYDRDTRGGRAKFAYTIGEYTRLHWNYRLENYEITNVDDDAHRDIKDLEGENWSSGAYVAAIRDTRNRRINPSRGTRNLLSVEYAGGLLQGDDNFIKYIASSDYYRPVLNRSIFHWKGQAGYVMRNTDEDIPNFELFRLGGINSVRGYAARKLAPRFDDGEVKGGDKHFFTNFELLHPLNEEIGLMGLVFFDAGNVWDKGESVDFDLYKSIGAGVRWYSPMGPIRVEYGYALDDLEDSSRSQIEFSMGHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPT3</accession>
    <name>D6SPT3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870077.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2135"/>
    <dbReference type="EnsemblBacteria" id="EFI34759">
        <property type="protein sequence ID" value="EFI34759"/>
        <property type="gene ID" value="Dthio_PD2135"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1328104at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023825">
        <property type="entry name" value="CRISPR-assoc_RAMP_BGP1436"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03986">
        <property type="entry name" value="TIGR03986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="668" mass="76346" checksum="F4D6607524435C80" modified="2010-08-10" version="1">MSKDREFFINPYTFVPLDKSGPVIEVPENGPDNAHHLYFEKDCFTGRLEVELSFITPAVIPGDQQAGTEKAPGSIKLYRHNDKLAIPGSRLRGHLFNLMKAINSSPVTAYNDRAILAREPGDHQKGYIIQENGQLYVVKINDEILMAAQDRSGKLFFEQGKPKTKLTLSNGADIIEFNVDSPKSGTYGELHYGHPKNKTGKYKKYLSDSSGISVTGNWVYFPSWSGQDGLNEIKDINNKTKAHKIDAHIVDIKQISNRRYRLDKDVVEKFQKNVSEMAKLLQDRGECSSKVYNRVRQMSELKPGMFVYFEANGDTVTSIGRHYRYLSHQGSIEETVERTNKELSNKTCLLPFTGGFASDSDSSEGLKSRLWVDMARCITDEPPVEEKNLRILSSQPPKAACFYLNGKGYDDNKATIRGRKFYWHDSKWRWQLWDNHDQKCGLHAFENPFPNENKKQWARSEVIMADENTHVSFRFSIRFMNLSRDEIYLLMTAIEGFDKNEDGKQWMHKIGHARPFIGSACMTVNSMHVLGFDSQYLKPVVQNDDLEVIRDDLASWQEKFEQKRNIQALKRIMSFEGAYYKAKTARIMYPVKYKDNSTPNWKDSSDAPKTFEWFVKQDKGKVPPPVLPDPASDEPQYLPINWTPQNRGGQMPGKGPQGKKKSSKGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ05</accession>
    <name>D6SQ05_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2221"/>
    <dbReference type="EnsemblBacteria" id="EFI34831">
        <property type="protein sequence ID" value="EFI34831"/>
        <property type="gene ID" value="Dthio_PD2221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="9716" checksum="CB561650FA3A04BA" modified="2010-08-10" version="1">MPTWILKPTVTHRRGERSAVMAAVRRHILPGVTTRREGSGYLAVLSGCRSDRGSGECRTARVWTSAVAAAASSTVIRYQFGLELVEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ61</accession>
    <name>D6SQ61_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870201.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2278"/>
    <dbReference type="EnsemblBacteria" id="EFI34887">
        <property type="protein sequence ID" value="EFI34887"/>
        <property type="gene ID" value="Dthio_PD2278"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="700"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="945"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1065" mass="119971" checksum="F403E47383AAE847" modified="2010-08-10" version="1">MPKKSPRKMHANPLEKPCFESPQDILMHAPVGIFISTPKGLAVSANHALSRMFGYDSPDEFTGTVKDIWSQLYVDSADRAEIISLVHKQGAVNDHECRMRRRDGSIFWSSQNIRADQDQHGRLNHYQVFITDISARKQSPEPSPTGLTSYVLDTIPDLIFIKDMHGVYIGCNSAFASHLGRDRDEITGKNDYQLYSAEMADFFREKDKQVLKRAASGSNEEWISYPDGREILLETLKTPYRDQHGNITGIVGIGRDITGRKMAEKALEESEKRFRIVFENLPGGIFIHDLDGKILMANDTACKNTGYSMQELLNMYIKDIDVHALNPEGRFEAWDLLREGQSISVESMHTRKNGSSYPTEVYLNAMSLDAKPVIFAVAFDITVRKRMEKALQESESSFKMLAEKCPISIMRFDRHGRVNFVNDWHIDKFAFNRLDKDFFLNRSVHELPGLVNAGIDHEVAKIFKGRTVEMDEVFFPEFAAGGPGWVSIRAVPVYEKGVVAGGILIRENITQRKKADEALRISEQKYRQLFESSPVSLWELDFSEVKKRLDALQAEGVQDLHSYFAGRQELIWEMADMVKVLDVNQQSLNLFRARTKRELMTGITSIFDKESQNKNFIQFLKVMACRGQGVVVERDHVTLDGQKLKTQVYWSVASGHEQDYSLVLACIVDNTDLLQTRQQLYQAKEQAVAANQAKSHFLATMSHEIRTPINGIMGLMQLMQDTTQDREQQEYVDLALTSAQRLTRLLSDILDLSRVEAGKMTIQEEKFSPRDLAGSVAELFKVTAKDRGVSLECILDPGLPGEIIGDPARVRQILFNLVGNAVKYSEHGNVNLHMTPVPAGRNEDIRVLFIVSDTGIGIPEDRIKTLFDPFVQVEDYQTRKHQGAGLGLAIIRRLTQLMGGNISIDSTEGEGTAVYVALPFKLPDKASLPEYEQQPQSDETTQGLRILLAEDDASNQFPMLKILEKMGHEVVLAADGQEVLQILEEQDFNCIIMDIHMPIMSGTEAAGIIRRSRKIGNNRDIPIIALTASAMHGDREKFLQSGMNDYLAKPVKAADLQRVLQKHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQE0</accession>
    <name>D6SQE0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MgtE intracellular region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870280.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2358"/>
    <dbReference type="EnsemblBacteria" id="EFI34966">
        <property type="protein sequence ID" value="EFI34966"/>
        <property type="gene ID" value="Dthio_PD2358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1992240at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="189" mass="21112" checksum="F5081CA1F40882A7" modified="2010-08-10" version="1">MIMVLAVIKLGLIFALPGQKSQTEGEPVTQKAPVMETRLAMAAPGDNNNDGGDEDVEEVDEEDIPGEVQRLREREAELDRRERNLRDLEEELDAKLEELRGLQAEVDEMLKEADVVRDEKIAHLVDVYSNMEPPQAAQVLETLNEDIAVKVLAGMRGREAGDILTNVNPQKAARLSEMLTDLQLPFIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQG5</accession>
    <name>D6SQG5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2383"/>
    <dbReference type="EnsemblBacteria" id="EFI34991">
        <property type="protein sequence ID" value="EFI34991"/>
        <property type="gene ID" value="Dthio_PD2383"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8351" checksum="999FE0D0C941ACAE" modified="2010-08-10" version="1">MENVCIEIPREVLHSARTTPEELKRELAILLYQQNKISFGKARELTGLNVWSFQQLLGHRGINIHYDVERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQK7</accession>
    <name>D6SQK7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="11" type="ORF">Dthio_PD2427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870347.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2427"/>
    <dbReference type="EnsemblBacteria" id="EFI35033">
        <property type="protein sequence ID" value="EFI35033"/>
        <property type="gene ID" value="Dthio_PD2427"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="10">
        <location>
            <begin position="702"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="533"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="345"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="777" mass="87240" checksum="FFFBBAF06C0A5A25" modified="2010-08-10" version="1">MWGGLIKSFLMESRTNTLLEFPRVLQYLSQEAVSSPGRDFCTRIRPFTDPHELEKEQALLHEAISALQEYAVVLGSFPELDRVLPLLKDQDAVLDLEGLWGLQSFLEAANALQSSMQEIDPQGFPSLRATWENISWPGTLWSAMHRCISQSGEIKDDSSPELQDVRGEIRNLRSQCSRKVNESLSRENYSHYLQDEYLTISSDRYVLALKSNFKGKVQGIIHDYSQTGETCYFEPMFLVDLNNRFQELLQLQAEEERKVRAYLTDLARRSLDALQQVYSWLIRMDVLWARARMAGRLQGRVLSREGEDSLELKNLRHPLLVLGGHHVVPVDVSLRPGQKALVISGGNAGGKTVCLKSLGLAAIMAQSALPVPVDEGSSVPFWDKIFVSMVSQQGVEESLSTFTDQIEHFSRFWPEVDSRTLVILDEFGVGTDPAQGAALAQAVLDALLDKGAWTATATHFPALKAYALSREEVRACSVLFDPETKRPLYRLAYDQVGASRALKVAREQGLPGEIIDRAQEYLLLEGEEQNRLFERLNQLAAQREQELAGLKEEKTRLARKLEKKRQDLARDQERLMQELKGQGQEIVRKWQEQKVGRKKALKELSEVRRAAEELGTGEKDASEPAGLALEDITIHDAYFYPAWNRTGTVREKDERKKQVKIDFGGISLWVNPGDLKLPRKSTGAKPSAGYSSSTGGAQSIRLDIRGKYRDEALEELEKYLDQAMLSGRKQVEVIHGKGTGALKKAVRQYLQRSPVIKDFSPGASESADDGVTTVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQN8</accession>
    <name>D6SQN8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870378.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2458"/>
    <dbReference type="EnsemblBacteria" id="EFI35064">
        <property type="protein sequence ID" value="EFI35064"/>
        <property type="gene ID" value="Dthio_PD2458"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ITE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1912871at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088160" evidence="1">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="210" mass="23856" checksum="6B7E8782F5C457AE" modified="2010-08-10" version="1">MIQRCIILITGVIILALTACAPREPVHYPPEDAVVAVAGFSQPKHRWEMITNHITVDQKKIDKDVIEKLDSDLAALLRQSRQKIVYPEMVKQCKELVAADTRPESSAFHFWVQVGKCIPADYILVPFVFEWRERIGGPLGVQEPAAVVMELNLIDLQDLQLQRFFFDERQFALLEDLSSAGKFFRRGGKWISARQLANEGLEQGVRELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQQ6</accession>
    <name>D6SQQ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="15" type="ORF">Dthio_PD2476</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870396.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2476"/>
    <dbReference type="EnsemblBacteria" id="EFI35082">
        <property type="protein sequence ID" value="EFI35082"/>
        <property type="gene ID" value="Dthio_PD2476"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="39"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="224"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="425"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="677"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="586"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI35082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="834" mass="96108" checksum="9A09307165CD0110" modified="2010-08-10" version="1">MQERRYSPEEIEKKWQQIWEEHKTFEVTHRETDRPRYYVLEMFPYPSGRIHMGHVRNYSIGDVVARMKMMQGYNVLHPMGWDAFGMPAENAAIKNNTHPAHWTYQNIDYMRSELKRLGYSYDWSRELATCHPGYYQWEQLFFLKFYEKGLVYRKKAPVNWCPTCVTVLANEQVEAGQCWRCDSMVEKRELSQWFLRITDYAEELLKDLDQLSGGWPERVISMQKNWIGKSTGMEIDFPVQGLDEKITVFTTRHDTLFGATFMSLAPEHEMVPRLIRDNPDQEKIQEFISRTTSQEHEERTADDTEKEGIFTGSYCINPATGKKMPIYLANFVLAEYGTGAVMAVPAHDQRDLEFARKYSLPVRVVVRPREMDEPLPEELDEAFADPGLAVNSGRFNNKPTSQVQEEIADYLEGLQAGRRAVNYRLRDWNISRQRFWGAPIPVIYCEKCGIVPVPAGELPVVLPQEAELPRDGRSPLPEMESFIRVDCPECGQEARRETDTMDTFVESSWYFARFTSPRKADGAFDSEAIKYWLPVDQYIGGIEHAILHLLYARFFVKALRDLGYWDLNEPFANLLTQGMVLKDGAKMSKSKGNVVDPDEMIRRFGADTVRLYCLFASPPEKDLEWSDSAIEGSYRFLNRLWRTVHELSGVISPVGPCLAMEGQGLTPEEKELRAAEHEAMRRATRDMLDRFQFNTAIAACMELLNTIGQHRESLRQSPSGPQVLSSALSTVLTVLAPITPHICEELWSHMGYQHSLAWSRWPEYDPRAVVRQEITVVIQVNGKLRSSINVPAEMDQEELKNLCLEDEKVKKHIQGKDVVKVISVPKKLVNIVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQW7</accession>
    <name>D6SQW7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870457.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2538"/>
    <dbReference type="EnsemblBacteria" id="EFI35143">
        <property type="protein sequence ID" value="EFI35143"/>
        <property type="gene ID" value="Dthio_PD2538"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030894">
        <property type="entry name" value="Ahb_Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034479">
        <property type="entry name" value="AhbC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00543">
        <property type="entry name" value="alternative_heme_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04546">
        <property type="entry name" value="rSAM_ahbC_deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="36"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="44105" checksum="B07AFFE7AA3DDE19" modified="2010-08-10" version="1">MIGISKLYCGAVEAADALRYGRQAGKMPSHLLQFSKDKKPVVVWNMTRRCNLKCVHCYAQALDEQGTDEIDTPAAKEIINDLADYGAPVMLFSGGEPLVRRDLVELASHAVGRGMRAVISTNGTLITRDKARELKDVGLSYVGISIDGGPEVHDRFRGVPGSFDKAMQGVKNCQEQGLKVGLRFTVNKRNVTEVPKIFQLLKDMDIPRVCFYHLVYSGRGSELINEDLGHQGTRELVDLILDETRALFDAGMPKEVLTVDNHADGPYIYLRLLKEDPQRAREVLELLQFNEGNNSGRGIGCISWDGSVHPDQFWRQHVVGNVLERPFSRIWEDESIELLQKLKDKKKYVGGRCAGCRFLNVCAGNFRARAEAFYGDIWAQDPACYLTDEEIKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQY7</accession>
    <name>D6SQY7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870477.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2561"/>
    <dbReference type="EnsemblBacteria" id="EFI35163">
        <property type="protein sequence ID" value="EFI35163"/>
        <property type="gene ID" value="Dthio_PD2561"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7PK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1402735at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025245">
        <property type="entry name" value="DUF4197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13852">
        <property type="entry name" value="DUF4197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="245" mass="27509" checksum="607369C085322764" modified="2010-08-10" version="1">MGKYWLFMAFFVAVLLGGSELRAQDWLQRGMDALRDQPDATEKSGLADSEIAEGLREALRIGSENVISHLGREDGYYQDPKAHIPLPVSLQNVQNILERAGMGHMLDDLELRMNRAAEQATPRAREMFVQAISEMTLDDVRGIYNGPDDAATRYFEGTMSGPLSEEFTPLVRESLADVGAVRAYEDLMSRYQQLPFVPDARADISKHVVDHSIEAIFEYLAVEEAAIRNDPLKQTTSMLQRVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR38</accession>
    <name>D6SR38_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870517.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0477"/>
    <dbReference type="EnsemblBacteria" id="EFI33154">
        <property type="protein sequence ID" value="EFI33154"/>
        <property type="gene ID" value="Dthio_PD0477"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033F8U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1963045at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088166" evidence="1">
        <location>
            <begin position="22"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="20731" checksum="BFC2E36964687A15" modified="2010-08-10" version="1">MIKKFLLSIALVLLLLQPANAFELTDDRVERFVDSWSDVQSLEHEFEDIEQPDGEFVPESPFSASLEEVRGHEAYDRLQQIAVDHGFSDAQEWALTGDHIFRAFLGMEMQDEDPTAEMKQALEEIRQSPLPEEQKEQITRHIQEQLDLFERIQDVPAEDIETVRRHEGEINRIFEPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRG6</accession>
    <name>D6SRG6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4168 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870640.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33282">
        <property type="protein sequence ID" value="EFI33282"/>
        <property type="gene ID" value="Dthio_PD0608"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033N5R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025433">
        <property type="entry name" value="DUF4168"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13767">
        <property type="entry name" value="DUF4168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088277" description="DUF4168 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4168" evidence="2">
        <location>
            <begin position="51"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="126" mass="14405" checksum="824C6F7CEF0DA31D" modified="2010-08-10" version="1">MKKNQLFITTALFSVVLFVFSLGAVHASNYDDVFESEIDEETELSADDIEHEDLQAFVQASKELKEIRAEYTNLLHDAEGVLYEDLRSEAVEEMQEAIDDAGLDEETYRGIGYHVQEDDELLADFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRL5</accession>
    <name>D6SRL5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870689.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0659"/>
    <dbReference type="EnsemblBacteria" id="EFI33331">
        <property type="protein sequence ID" value="EFI33331"/>
        <property type="gene ID" value="Dthio_PD0659"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9074" checksum="BD03FBF0DB6BB472" modified="2010-08-10" version="1">MPTLTATEARSKLYRLIDEAKTSHEPIVITGKRGSAVLVSEDDWRSIQETLYLLNIPGMRESIRKGLATPIEECSEEIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRR7</accession>
    <name>D6SRR7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870741.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0714"/>
    <dbReference type="EnsemblBacteria" id="EFI33383">
        <property type="protein sequence ID" value="EFI33383"/>
        <property type="gene ID" value="Dthio_PD0714"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZD3S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1497438at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="16826" checksum="3C3A68636E5BC286" modified="2010-08-10" version="1">MNKQSGFTLVELIATITLLGIVSVIGGMFLVQIVQSYQWAGDNYHLAQKTQVVMTRVSNELQTAGSFGYNCRRDDELEYTTHNGDDVTISRDNSNLDYQTNNSSYTLVDGVSDFQVEYLSNGVCRITLEISGANDALQEFSFAVAPTYLSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRX2</accession>
    <name>D6SRX2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">Dthio_PD0772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870790.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0772"/>
    <dbReference type="EnsemblBacteria" id="EFI33438">
        <property type="protein sequence ID" value="EFI33438"/>
        <property type="gene ID" value="Dthio_PD0772"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039018">
        <property type="entry name" value="VapC20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42188">
        <property type="entry name" value="PTHR42188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15381" checksum="B21890037F035E25" modified="2010-08-10" version="1">MIFVDTGPLLARYLLKDQFHQHALNIWAELEKSHERLATSSLVLNETATLLGRRTGNIFAAERLNNIYASHAFQIWRPDREDELRALKLFAKFSDQVVSFTDCVSFALMTSKHVPQVFTFDRHFDLAGFKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS29</accession>
    <name>D6SS29_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HhH-GPD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0829"/>
    <dbReference type="EnsemblBacteria" id="EFI33495">
        <property type="protein sequence ID" value="EFI33495"/>
        <property type="gene ID" value="Dthio_PD0829"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="215" mass="24835" checksum="A70CDB0A8A2029C1" modified="2010-08-10" version="1">MSSSTLLMHFYETLLASLGPSQWWPGETPFEICVGAVLTQNTNWSNVQKAINNLKSRDLLHPEKMASLDDELLAELIRPSGYFRIKARRLKNLLEFLRLECAYHLPDLSSQDLQQLRDKLLQVKGIGPETADSILLYALEKPSFVVDAYTSRILNRHLLVHEDIDYHELRDFFMDRLPRDVALYNEYHALLVRTGKKWCNKNNPRCDGCPLGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSG8</accession>
    <name>D6SSG8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD0969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870983.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0969"/>
    <dbReference type="EnsemblBacteria" id="EFI33634">
        <property type="protein sequence ID" value="EFI33634"/>
        <property type="gene ID" value="Dthio_PD0969"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="316"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="568"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="784" mass="88132" checksum="D1A1D65D1530F603" modified="2010-08-10" version="1">MKTGNASSSERRCPEKSHDEQSLILQLKNLQHVYHRLLMHMPDGCALLSRQPGSGKEEEFFIQEVNPAFEDMTGAAGQELMGRSTLQALPELATRLNRACMQAMGGTQPVDFQHFLSSQAKYFEVRVFAVGENICMGVFSEVTGRMHFQEALRESREKYRTIADFTYDWEYWLSPQGEFLYISPSCKRVTGYTPEEFKYDPDLFRRIIHPDDLPLLNCLKSCDHELQQESHSETDFRIRTRDGREVWISHSCTPVFSETGEYLGRRGSNRDITDRKVAENRLQEFAVEVETQNLELARARNRAQEASKAKSTFLANMSHEIRTPMNAILGFAQVLEQDPDLTPRQAGHLKTITRSGNHLLRLINDILDMSKIEAGQVQSSPEDFGLVDMLEDMGLMFSSRAEAKGLQFILERDRHLPGNIRADQGMLRQIMVNLLGNAVKFTSSGGVACRVRTEPAQDTGEKDDSRLRLTIEVEDSGPGIQEIDQQKLFEPFQQAEEGIKEGGTGLGLAISRSFARLMGGDIEVSSTKDRGSLFRVHILVETSTGPPRTEKKPERIIQGLQPGTGPVRILIVDDRLDNRSLLQAILEPMGFETRQAENGAHCLEIFQDWPPHAVLMDMRMPVMDGYEAVERVRGLPGGRDCFIMAVTASAFEEDRQEILNTGVDAYLRKPFQNVELLEELGKGLHLQYIYACNDAPGENAAGPHACLAAPGLPGHILEDLSLAVSEGDILVLEKIAGKLHRTDPDAADTLLKMIQNYDYRGIESWLKQVEEQNETQYAEDTDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSV2</accession>
    <name>D6SSV2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hpt protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871117.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1107"/>
    <dbReference type="EnsemblBacteria" id="EFI33768">
        <property type="protein sequence ID" value="EFI33768"/>
        <property type="gene ID" value="Dthio_PD1107"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZK16">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2170629at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="14020" checksum="559CE77E53E1FBD6" modified="2010-08-10" version="1">MSCRDFENLPRFDQQEALERCMDSLDFLQELADVFVSESLPMYLPRIQEGVDNRDFDKVAGNAHGLKGGCSSIGLTRLREMSYCLEKAGKDKDLQTMERVVAELTQEAQKVEQLITSRELWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSY2</accession>
    <name>D6SSY2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1137"/>
    <dbReference type="EnsemblBacteria" id="EFI33798">
        <property type="protein sequence ID" value="EFI33798"/>
        <property type="gene ID" value="Dthio_PD1137"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087950" evidence="1">
        <location>
            <begin position="26"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="37720" checksum="607FA96AAD17AFF1" modified="2010-08-10" version="1">MKIKTTFTIFCVFLALIYSGCQALASEMKILDQQTIQDQGGRTIQVDEPFERIISLYGAHTENLFSLGLNQEVIGVGMNECYPPQALERPSFSYQEGPEKILAHRPDLVLVRPMIDWAYPRLMDTLERSGITIVSLQPGSKDEMFKYWKILGILTGKEEQALQMQENFKAGLEYARSLTAHVEDKKGVFFESIHEQLKTFSPDSMPMLVLEAAGGENAALDARQVRGTNIADFGQEKLLSRADKVQVYLSQQGPMNQASPENIKKRPGLHLLKAVQQNRVYAIDEVLVSRPTMRLLQGIYVVGEHLYPDIFHEDTREKLDNYRKMQGSESEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST18</accession>
    <name>D6ST18_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1173"/>
    <dbReference type="EnsemblBacteria" id="EFI33834">
        <property type="protein sequence ID" value="EFI33834"/>
        <property type="gene ID" value="Dthio_PD1173"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="247" mass="27343" checksum="D33801F5341DE2E2" modified="2010-08-10" version="1">MKKKFAMVVDSSVCIDCKACMASCKVEHGLPRGYWRNWIKEKSPDFSMGKNTYAHYQPGGCMHCDNPTCVHACPSGATYKEEETGIVQINKDMCIGCGNCVVACPYSARYRHPTLRVPDKCDYCQDRLAMGLQPACVDTCPTKARVFGDINDSESEAATLLKDREWVQINTEPEDTDPNMYYLADTEPMDWPGEVEYPAAHATMTRLVNPLFKVAVGLSALGAAVMFIKQITSGSETSGHDEKKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST65</accession>
    <name>D6ST65_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871230.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1220"/>
    <dbReference type="EnsemblBacteria" id="EFI33881">
        <property type="protein sequence ID" value="EFI33881"/>
        <property type="gene ID" value="Dthio_PD1220"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2032706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="11712" checksum="3B0740CE301809B0" modified="2010-08-10" version="1">MTASKHMGQPFDQFLQEEGIYEEVQLMALKKTISHQIRVLMDKENIKKAELARKMGTSRSSLERLLSDESSNITLHTINKAALVLGKRLDISLVDLHPEEAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STB0</accession>
    <name>D6STB0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IMP cyclohydrolase</fullName>
            <ecNumber evidence="2">3.5.4.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.10" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871275.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1265"/>
    <dbReference type="EnsemblBacteria" id="EFI33926">
        <property type="protein sequence ID" value="EFI33926"/>
        <property type="gene ID" value="Dthio_PD1265"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1194473at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="197" mass="21640" checksum="2E24EE5673F870B1" modified="2010-08-10" version="1">MQLLPVKRALVSVTDKTGITELGQFLSSMEVEIISTGGTKKMLQDSGVTVTSVSDITGFPEILGGRVKTLHPHIHAGVLADKDNPEHMDTLDSMNIQPIDIVCVNLYAFEQAVQDDPGIEKAVEQIDIGGPTLLRAAAKNHASICVLPDPEFYQPCMDMLRDKKGIDLDFRIKTASFTFAKTSRYDQVISGYFNQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STF9</accession>
    <name>D6STF9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871324.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1314"/>
    <dbReference type="EnsemblBacteria" id="EFI33975">
        <property type="protein sequence ID" value="EFI33975"/>
        <property type="gene ID" value="Dthio_PD1314"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503408Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1215665at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="1">
        <location>
            <begin position="136"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="231" mass="27037" checksum="77E774A4C09FCAF2" modified="2010-08-10" version="1">MSKKYSVILMRDDTSVRKFRIRPFWIKFFIALFFLAVTAAALGGYFTITFYQEKRHVREDLQVVSKNLEQTAEELEKKRNIQKIFETYESQDLHSFLTVNDTRRNIVPPVDLVEVFEYKDRGIVGVDNVQAGFNGDRMRVRLDVNNMAEGETISGRIFLHLVRRDGQQVDLDLDHDDLDYAISRFKNVDVTFELPEELSPESIFALRVKARDDDRRLLYSETFPLSQIQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6STK0</accession>
    <name>D6STK0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871365.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1355"/>
    <dbReference type="EnsemblBacteria" id="EFI34016">
        <property type="protein sequence ID" value="EFI34016"/>
        <property type="gene ID" value="Dthio_PD1355"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1626243at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="252" mass="29762" checksum="E8574DD7BA438F64" modified="2010-08-10" version="1">MAIISHKNKFIFLKTRKTASGSVEVALAGVCGEQDQLCPTGDGKELGITEQNNQKPLKQVDVKDLGNFFAAMWKNTIKAGNPEVRHSWNKTRRIIKSSHFNAENMQKVCGKEVWNTYYKFCFERNPFDRLVSFYHWRTKKFKNPPSFRDFALAVIGKNKKQASRLKATNFSNRPFYEIDGEIVVDRIFHFENLHEDLSTFFMSKKIPWNGELLHTKAGFRPKKDYREYYDPELRRLCEKAFKFEMEHFKYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STK7</accession>
    <name>D6STK7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1362"/>
    <dbReference type="EnsemblBacteria" id="EFI34023">
        <property type="protein sequence ID" value="EFI34023"/>
        <property type="gene ID" value="Dthio_PD1362"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZE0C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="277" mass="31615" checksum="F55492100EBF3DD4" modified="2010-08-10" version="1">MGLRTCLIGLLKKKSIQALYNSSMVIADTEFTCLRPLGQETRPGLTKAGRLSFCAMLEGRKVKIYETHSQRQTNLRQKIQNTVFGKSFLPGIIASEGTYVVEEWIHGTSALTSKAGIKKTVETMIQVLLQDPKLINLAQEQAMSFCYLQNYLYPRVAKWSILSPVKDFTKEWQKRFDELRPHLPIRISHPDLSPANIICQEASDRKVIIDNELLGSGFGWILDWHNSLLKEQKSVSLELIQQHVPEDFLEKTWRLRLLGSALDREDYTQALKIAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6STM3</accession>
    <name>D6STM3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871388.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1378"/>
    <dbReference type="EnsemblBacteria" id="EFI34039">
        <property type="protein sequence ID" value="EFI34039"/>
        <property type="gene ID" value="Dthio_PD1378"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="189" mass="21059" checksum="596CC166FD18E910" modified="2010-08-10" version="1">MTFKDNPALAVIDMQNDVVLPGSPCHVPGAMETIPAIRNLAEHFRNNKWPVIYVVRGHRQDASDLEYTRLQLFMDKGGICVTGTKGAEIVDGLEVKPQDYILVKKRFSAFLFTEFDLLLRRLNIKTLAIAGTQYPNCIRSTAVDALARDYRVVVVTDACSASSRRIADNNIEDMQNMGIECLSLGQVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STM4</accession>
    <name>D6STM4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871389.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1379"/>
    <dbReference type="EnsemblBacteria" id="EFI34040">
        <property type="protein sequence ID" value="EFI34040"/>
        <property type="gene ID" value="Dthio_PD1379"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="753726at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="204"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="411" mass="46864" checksum="126E0973FC7A4C4D" modified="2010-08-10" version="1">MEVLQHHPVFVARQPIFTRNDRVHGYELLFRDGQMQQSANVVDPVQATLDVISYGFDLAASAMGRPKPVYINFPQPLLLERSALALPADQCVVEILETVRPDPEVIEACLDLKKRGYRLALDDFFGQQGYEELIELADVVKVDILKMHPKEIKKIVEYLSEKKVRMLAEKIEHVKIYQYCKQMGFNLFQGFFFCSPQLMSGCKLTPNQSSRLELFKKLSQEEVEPKQIARIIQEDAALSYRLLRYINSAFFGFRSRISSIEHAVNLLGILQVSQWLKVVILSDLSTTATGQETSRLAAQRGKFLELLSDSHPEPPFQPHTMFLLGLFSLLDALLGQPMEDILQDLPLQEEVKKALATSDTPFFPWIRLVKCMEKGYWDDVFTGCQELGLKQEEAASVYNASVVWTSRSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6STQ1</accession>
    <name>D6STQ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871416.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1406"/>
    <dbReference type="EnsemblBacteria" id="EFI34067">
        <property type="protein sequence ID" value="EFI34067"/>
        <property type="gene ID" value="Dthio_PD1406"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1559099at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="32532" checksum="558DCBA717814E5A" modified="2010-08-10" version="1">MTLDTLHTSAMLFLSIVFESAPFILLGALFSSLVLVFIPADFFRRKLPRNPVLSLPPALALSAVFPVCECAIIPVVRGLVRKGMPISAGTVFLVAAPILNPVVLASTFYAFRFNLDVVVLRFVLAAAAALIVGFIVYLALESGGRRPFARDLPMAGETHSRPSFFSPGTWKRVLDHSIDEFFTIGKYFILGAGVASLFQTYMSQQAVMAFTESAFIAPMVMMLLGYVLSLCSTADAFVAASFAGTFTPMSIVAFLVFGPMLDIKNTAMLLGYFPLRFVILFIAAAAATVYTLVVTMQFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6STR8</accession>
    <name>D6STR8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871433.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1424"/>
    <dbReference type="EnsemblBacteria" id="EFI34084">
        <property type="protein sequence ID" value="EFI34084"/>
        <property type="gene ID" value="Dthio_PD1424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1439550at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025048">
        <property type="entry name" value="DUF3987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13148">
        <property type="entry name" value="DUF3987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="321" mass="36065" checksum="E60DF6DCD312D086" modified="2010-08-10" version="1">MTAYDGSKPWKISRATSDRSNFIPEPCVSLYGGIQPAIAKDLFNNKDIDSGFLGRFMFIQAIQRVPATFSEEEESMATQETLKKLVNGLDSFSFHETTQYIQVSAEAKQTFISWHDKLAYEAWFAENDGEGSLLNKIRAQGLRVCLILHCIDAVMNEQDEMMKISNDTMVKALKLMDWIRTHTQATWKMLMDKAATPSGQDVRVAQAIFALEGEITNSWLPTGRITELVNDGLDHRYHLTAEQVGRACKGLQLENKAKSHARGFIITPEDIKRLSSFVPEKEPSYLSYVSEPSIDGAYEYDTSESAPSYPSCHEDDEGVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STT0</accession>
    <name>D6STT0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871445.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1436"/>
    <dbReference type="EnsemblBacteria" id="EFI34096">
        <property type="protein sequence ID" value="EFI34096"/>
        <property type="gene ID" value="Dthio_PD1436"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032W1M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2009549at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="236" mass="26855" checksum="E439260EA529950F" modified="2010-08-10" version="1">MKAHFVSEQEVRAVPEVQGTDTWNPVHHSLVIDAVEHAVSEAGLGIQSKCFELTTGGGNLFASYRLDQGRDGVNWQIGFRNSIAKRFAVGITAGTYTMVCSNLVFAGDFVEFRKHTKGLDTDELFAMSGRAIETTVHRLESLEAWQLDLKNIPLSQRHMRILSFEAMRKQAFPASRFHRFLEAYKEEVALNGLTLYSFYHSITRTIRDQSLSRISTRSEVLNQLVQDYQHWLSRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6STX1</accession>
    <name>D6STX1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871486.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1479"/>
    <dbReference type="EnsemblBacteria" id="EFI34137">
        <property type="protein sequence ID" value="EFI34137"/>
        <property type="gene ID" value="Dthio_PD1479"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="883503at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="FliD_N" evidence="6">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="7">
        <location>
            <begin position="227"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="577" mass="64804" checksum="ED871F6FAB05083E" modified="2010-08-10" version="1">MPDLTSGQIRFDGLGSGMDFDQIVNQMVQIEGRRIQRLQQDMQQEQVKMEASQELQNSMVSMRSEMDSMNTLDDFFIRSAESGQESVASASADSSAEEGSYNLEVGQLARNHIMFSNEGFEETDDVVNSSGETRTFSYQYGPEEGEDAHERVDLEVPEGTTLQGLVELINEDPDNPGVRATLINDGNEYFLQLKGMDQGADYKVEIKDEETDLDGFKADDFDTSQEAQNSKIKVDGWPRDEVDEDGEVTEERWIERDSNSVDDVIEGVTLNLYETGETQITVSDDHEAIKEQVQEFVDSVNNVLAMMQGVSRIEEDEEAEDDDMAGPQTSLLTGNYGVRMVQDRIRDVLASAGVGFDRDDDPFPNLGSIGISTVTDEEEEDYGLLRLDESRLDEVLDEDPQAVAEIFSADNEPSTDTSDFRFASQIEGTTRPGLYDVSYTMENGEITNAYIDGEEARFDNQEMTISSRSGDSRGLVIRVDNLSDGEYQGNVRLKQGKAGELSDAVREMTDPESGTFKIMERGYESTIQSLERSIESEQSRLSSYERHLRNRFARTEEMLGRYEGMQQSIFQMRQQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU18</accession>
    <name>D6SU18_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871801.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0424"/>
    <dbReference type="EnsemblBacteria" id="EFI33109">
        <property type="protein sequence ID" value="EFI33109"/>
        <property type="gene ID" value="Dthio_PD0424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="19836" checksum="2E3EC2B414744111" modified="2010-08-10" version="1">MIHRVLDKSKQKEVEELFTSVFTASEGEKEGKLLGNLSSQLASNLDNNEIICFGVYEKEILIGSIFFTRLEFSKPIQVFMLAPVAVSAEHQGKGIGQALINYGLNELKKRSVNVAVTYGDPSFYSKVGFQSLSENVIQAPLKLSMPFGWLGQSLTVEPIPTINERPMCVKEFNAPVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU30</accession>
    <name>D6SU30_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871812.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0436"/>
    <dbReference type="EnsemblBacteria" id="EFI33121">
        <property type="protein sequence ID" value="EFI33121"/>
        <property type="gene ID" value="Dthio_PD0436"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="224"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="460" mass="52678" checksum="C66080E4ADB5795E" modified="2010-08-10" version="1">MSIKRSAEDYLVEWKDRSSRKPLILRGARQTGKTYLVEQFAKNHFRNLLKIDFEFDQEVKSVFRQKDPQTIISELSLFFDLPVIPGETLLFLDEIQSCPEAIHSLRYFYEKLSGLHVIAAGSLLDFVLRDFEYSMPVGRVEFLHLYPLSFSEFLLAVNARLHEFITNWTPPDQFSPVVHGKLTELMRTFIFTGGMPEAVASWIKQRDYVEVQRIQSAILSTMQHDFAKYGSRIQQDHLQKILQFIPGNIGNKVKYVHVDRDVRSTALKDAFHLLAMARVISLVFKTNANGVPLEAEKDRNFFKAIALDVGLVNRMCGLKLIRPEELMTVYEGGLAEQFVGQELLGSRPCFEEPALYYWAREAKNANAEVDYLVTHGSQVLPVELKAGKTGTLRSLHVFLHEKKSDFGVRLNMDTPSLGRFTAHVRLKKSSTEHEYTLLSLPLYLAGQLDRLLEHALDQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU49</accession>
    <name>D6SU49_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphonopyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871525.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0136"/>
    <dbReference type="EnsemblBacteria" id="EFI32829">
        <property type="protein sequence ID" value="EFI32829"/>
        <property type="gene ID" value="Dthio_PD0136"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1219810at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033980">
        <property type="term" value="F:phosphonopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032923">
        <property type="term" value="P:organic phosphonate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017684">
        <property type="entry name" value="Phosphono-pyrv_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03297">
        <property type="entry name" value="Ppyr-DeCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="224"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="372" mass="39700" checksum="1F613F0BFB84E4BE" modified="2010-08-10" version="1">MINPEAFYKAIQERGIGLFTGVPDSLLKHLCAFVDHHCSTGNHILTANEGNAVALAAGYYMSTGKMAAVYMQNSGLGNCVNPLTSLTDPQVYSIPMLLIIGWRGEPGVKDEPQHVKMGRITPAQLDLLEIPYRVLDAATDPEPVLDDLFSVLESTSAPAALLVRKNTFQACTKAAKNAPTQGLKREQALRALLGLAGDSLVISTTGKTSREVFEIRTSLGHPQQDFLTVGSMGHASSIALGTALGNPGKKVICLDGDGAMLMHMGTMAITGSQKPQGLIHVILNNQAHESVGGQPTVAGNMDLRSIALGCGYSFFHQARDEAGIRQAWENLLDKQGPALLEIKIQPGSRADLGRPTSTPIQNKQAFMEKAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU62</accession>
    <name>D6SU62_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871538.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0149"/>
    <dbReference type="EnsemblBacteria" id="EFI32842">
        <property type="protein sequence ID" value="EFI32842"/>
        <property type="gene ID" value="Dthio_PD0149"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="2">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="366" mass="42053" checksum="02B78884329A7A4C" modified="2010-08-10" version="1">MKTTRTRKADMLEGEEGLAPDSSEVYPDAVVKISRDQYSAFEIKRMAETTYELVIAPPFQRRLVWSKKQKCELIESILMGIPIPVIYVFEDENGKKQVVDGRQRISTMISFMNNEYALERLKMLPVFNGDKFDDLEAIYKSKVERYQVPVYVIEPPTPERVKYDIFDRVNRGGTLLNSQEMRHALYNGQATALLKELSLARAFTDATGNSIKPIRMRDQYVILRFLAFYLFRNHKLNFSYKSNMDDLLAATMKHINQMRPHQLESLKQVFLSAMERSHAVLGGDGFRFAPANVNRRPVNMALFEVIAYFFAMTKTLPLDQVHLKSRLNSLKKTFDQSGVFSSRVDSSAAVEYRFGMVESLAGELTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUA8</accession>
    <name>D6SUA8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">Dthio_PD0202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871581.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0202"/>
    <dbReference type="EnsemblBacteria" id="EFI32888">
        <property type="protein sequence ID" value="EFI32888"/>
        <property type="gene ID" value="Dthio_PD0202"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="315" mass="33938" checksum="6FBAE2EA0AA5CE94" modified="2010-08-10" version="1">MPGHRELKIITGNANPELARGICDHLGMTLSPTLVCTFSDGESRVEIGDNVRGDDVFVVQPTCAPVNHNILELCLMLDALKRASVGRVTAVIPYYGYARQDRKVVPRVPISAKLVADFISVSGVNRILTIDLHAGQIQAFFNIPVDNLFAAEVLLTYLKQFGDQAVVVSPDAGGTERARAYAKRIGAELAIIDKRRDTPNTAQAMRVIGDVKDKVAIVLDDMIDTGGTMMEASKVLSEKGASKVLACATHPVLSGPAIERMEQSHFSEIVVTDTIPLSEKARASGKFQVISVASLLAKAIHNIHTESSVSVLFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUF3</accession>
    <name>D6SUF3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871626.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0247"/>
    <dbReference type="EnsemblBacteria" id="EFI32933">
        <property type="protein sequence ID" value="EFI32933"/>
        <property type="gene ID" value="Dthio_PD0247"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024570">
        <property type="entry name" value="Murein_transglycosylaseC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11873">
        <property type="entry name" value="Mltc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mltc_N" evidence="3">
        <location>
            <begin position="65"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="221"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="379" mass="44012" checksum="D35FCB59D7ABCDE2" modified="2010-08-10" version="1">MHRRDFIRLLILPCIFSGFGCQPSQIRQGISAGSQLARGSVSGAVTSMLPGTGVPELDSLVRRGVQEMVQRLMEEWGDEKVPTQTEYVKYTDDYQTRAVINFETGNIRVETVEEDNPRQKLKTAIVHTLLTPEDPARVDLLSDEQVSLGPEPFLHNVVLDHEDTPIRWEWRANRYAEYLMRTAYQTDVYNQRKRHFVTLSMVEEHGFQQQKRYQGLVYRHSRRFGVDPALVYAIMEVESSFNPYAMSHVPAYGLMQIVPETAGRDAHLFIYNRKGTPTRDYLFVPDNNIRMGSAYLHILFNRYLNRVTNARSREYCVIAGYNTGSGNVLRAFHSNRDRAFERINSMNSRQVYEHMVRNLPYQETRDYLPKVVRARTRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUG2</accession>
    <name>D6SUG2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA methyltransferase, TrmH family, group 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871635.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0256"/>
    <dbReference type="EnsemblBacteria" id="EFI32942">
        <property type="protein sequence ID" value="EFI32942"/>
        <property type="gene ID" value="Dthio_PD0256"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="3">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="240" mass="25864" checksum="775A4711BADF40F0" modified="2010-08-10" version="1">MHENLVLGKKPVMEALEENPEHIDLVLVKKPVPRGLDPVISRCRQLHVRFKLVPDQELQQMGAARQGIAARLRMQTLVDLDLLLNNTTRAVFPVLLLLDQVQDPGNLGTLARTLAALGGAGIIIPRDRSAPLGPGAMKASAGALNRIGVAQVTNLARTLDHIDQAGFNIYAATMDQGQSVLEQTFVFPAVLVLGGEEKGIRPNVLKRCPGKIHIPMAGGMDSLNVAHAGALILGRMLSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUG5</accession>
    <name>D6SUG5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine pyrophosphate protein domain protein TPP-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871638.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0259"/>
    <dbReference type="EnsemblBacteria" id="EFI32945">
        <property type="protein sequence ID" value="EFI32945"/>
        <property type="gene ID" value="Dthio_PD0259"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="2">
        <location>
            <begin position="60"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="251" mass="26797" checksum="5B9622234C7E41B5" modified="2010-08-10" version="1">MQEVLAYKSPDILADVPTHFCPGCHHGIVHKMLASGLEDAGLAQKSICVAAIGCGAFIYNYVLVDTLEAPHGRAPAVATGVKRSSPDSLVLVYQGDGDLASIGLAEIMHAANRGEKITVVYVNNTVYGMTGGQMAPTTMLGQKTTTTPLGRQSGSDGYPMQMTEIMSRLQGVSFAARVAVNNIKNLKKAKKALRRAFEVQEQGLGFGFVEFLAACPTNWRMNALDANARVDNEMIPCFPLGIHKDVAGEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUH6</accession>
    <name>D6SUH6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="12" type="ORF">Dthio_PD0270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871649.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0270"/>
    <dbReference type="EnsemblBacteria" id="EFI32956">
        <property type="protein sequence ID" value="EFI32956"/>
        <property type="gene ID" value="Dthio_PD0270"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="96"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="318"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="98"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI32956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="486" mass="52942" checksum="F421B0AF14809D68" modified="2010-08-10" version="1">MKSWKEIINEARQGRQVRSDSRQVCPGDIFVAMPGTKVHGNSFIPEALDRGAAFVVASEPAGQDRVLHHENPAMALGELARAHFGTDRLSMKVVGVTGTNGKTTTSYILEHIFTSIGYKTGVLGTVNYRWPGTVLKAGTTTPDCLDLHRMLARMQAHGVEVVCLEASSHALDQKRLAGIDIHVAVFTGLSRDHLDYHNDIEDYFQAKKKLFWPSNPQNFLGSVINMDDPHGRDLAGEAPRVMGYGLQKNFSPELQGHLVQSTASGLVMECSHQGRSWTISCSLPGIHNAQNLLAAQGAGICLGLEPEHFDCLKDLGPIPGRLEKVPAPEGINIYVDYAHTPDALENVCLALKELSFSRLAVLFGCGGDRDRGKRPEMARAVAAHADAVFLTSDNPRFEEPGEIIKDILPGLAGHPCVEVEPDRRQAIQKAVSLLAPGEALLVAGKGHEDYQEIRGVRHDFSDTGEIQMAVSKLQRKVTGPCHTEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUI4</accession>
    <name>D6SUI4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polypeptide-transport-associated domain protein FtsQ-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0278"/>
    <dbReference type="EnsemblBacteria" id="EFI32964">
        <property type="protein sequence ID" value="EFI32964"/>
        <property type="gene ID" value="Dthio_PD0278"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35851">
        <property type="entry name" value="PTHR35851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="279" mass="32261" checksum="1FD8FBB9120157EC" modified="2010-08-10" version="1">MTARRTRTRRNTGSQHSPRPVGVLRRFFSAVTGLLGLVLVLCLSLGILVLVSAALIHGYRYATSSEYLALQEIEIKGNQRLTYAEVLRLMQVDTGENMLKLNISRMQKNLADSPWIKQARVRRDFPDQLHVDIQEKQAYFWVQNDHNLYYADKKGRTIDRLSPERLVSLPVLHLHDGAGSRHVAEIVTTLERRRFPFSIQDISWIRITETGRAHMYIHGLDLELSLDCRELEPQTDKLNLVWNDLRRRQDIDAVKRITVAGENAWVAYRRQAKPENQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUJ0</accession>
    <name>D6SUJ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0284"/>
    <dbReference type="EnsemblBacteria" id="EFI32970">
        <property type="protein sequence ID" value="EFI32970"/>
        <property type="gene ID" value="Dthio_PD0284"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015985">
        <property type="entry name" value="TehB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03848">
        <property type="entry name" value="TehB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TehB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="181" mass="20484" checksum="EABE3B8F57190858" modified="2010-08-10" version="1">MQQHNASEPAGILKKHLHLFTASPLPGPVLDLACGSGRNGLFLAEQGLEVYFWDRDQSGLQKIHDLALEKKLKVHTKEVDLEAESESTLPPSFFGAVLVFRYLHRPLLPDIKNTLKPGGIIVYETFTSSQALLGRPTNPDFLLRDRELYSWFQDWEILHYFEGKTEAPQEYLAGLIARKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUN8</accession>
    <name>D6SUN8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">Dthio_PD0332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871711.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0332"/>
    <dbReference type="EnsemblBacteria" id="EFI33018">
        <property type="protein sequence ID" value="EFI33018"/>
        <property type="gene ID" value="Dthio_PD0332"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="123" mass="13993" checksum="0220B1A1F2448DE4" modified="2010-08-10" version="1">MPTINQLVRRSRDQVVKRKKRAALQECPQKRGVCVRVYTTTPKKPNSALRKVARVRLTNGIEVTSYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYSIIRGTLDTSGVRDRRKSRSKYGTKRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUP0</accession>
    <name>D6SUP0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="16" type="ORF">Dthio_PD0334</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871713.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0334"/>
    <dbReference type="EnsemblBacteria" id="EFI33020">
        <property type="protein sequence ID" value="EFI33020"/>
        <property type="gene ID" value="Dthio_PD0334"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="13">
        <location>
            <begin position="20"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="150"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="348"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="14">
        <location>
            <begin position="512"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="15">
        <location>
            <begin position="590"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="10">
        <location>
            <begin position="716"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="11">
        <location>
            <begin position="1280"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1025"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI33020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1363" mass="153957" checksum="B72CDD30F1A1AE38" modified="2010-08-10" version="1">MGLFTKNFGQIEYGLDVPHLLKLQLDSYMNFLQEEADPMNRQDQGLEAVFRSVFPIEDFNKSATLEYVSYEINQPKYDVAECLSKGLTYEAPIRIKVRLIVYDVDDESGNRTVRDIKEQDIYFGTLPLMTEKGTFIINGTERIIVNQLQRSPGIIFEHDSGKTHTSRKVLYSSRIIPMRGSWLDFEFDPKDILYVRIDRRRKMYVTILLKALGMSEEDILNYFYDREQLKFKDQKVYRKVRSSHFRKEIAYKDILDSEGNVLVRAGRPVTKRVWRQMAKAKEHMEIDPGILPKQFVAHDLVHPETGEVLAEVGDALEQDVVDKIFASGIEDVEILYTGGQDVSSSLRDTLKLDKTQDQLEAQVEIYKRLRPSSPPTPEIASSFFDNLFRNSDYYDLSPVGRYKLNARLGLNLPTDYRTLSNEDILRVVKHLIKLKDSHGPADDIDHLGNRRVRPVGELVENQYRIGLVRMERAVKERMSLQEVATLMPHDLINPKPVTAVLKEFFGTSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHPSHYGRICPIETPEGPNIGLIVSLTTHAQVNDFGFIETPYRIVKDGMVTNEVKYLDASKEADEVIAQANAPVDEEGRFTSELITSRIHGELNLMPRDEVTLMDVSPTQIVSISSALIPFLEHDDANRALMGSNMQRQAVPLLKPERPLVGTGMEGLVARDSGSCEIARADGIVRYVDANKVIVSYDEPPDKSSQDTVCYDLQKYHKSNQNSCFGQRPRVLPDQRFKAGDVLADGPSIVDGELALGKNLSVAFMPWCGYNFEDSILISERMVKDDVFSSVHIEEFEVIARDTKLGPEEITRDIPNVGEDMLKYLDDSGIIMIGAKIQQDDILVGKITPKGETQLTPEERLLRAIFGDKARDVKNTSLKVPPGIEGTVIDIKVFNRRSGEKDERTRIIEDRELDRLAQSEEKHVQGLTAQTRDRIWEVVSGKRLAQTIMGRKKGQVLAEANSTLQREDLDRIPLKKLAGSFASKEVNEAIEHLIKLYEEQLKFIQNVYSQKRDKVVEGDDLPPGVTKMVKVYVAVKRKLNVGDKMAGRHGNKGVVSCILPEEDMPFFDDGTPIDIVLSPLGVPSRMNIGQIMETHLGWAARELGRQLGRMLEQGVDVGVLRKEVDDIFNSPEISRLAAEMDDESFVRAVRELEPGILTKTPVFDGAKEEEIWPWLKKAGLSDDGKAVLYDGRTGDAFHNRITVGNMYMLKLHHLVDEKIHARSTGPYSLVTQQPLGGKAQFGGQRLGEMEVWAIEAYGASYLLQEFLTVKSDDVAGRVNMYEKIVKGNNFLESAMPESFNVLIKELMALGLDVDLLLDEKKKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUP6</accession>
    <name>D6SUP6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ORF">Dthio_PD0340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871719.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0340"/>
    <dbReference type="EnsemblBacteria" id="EFI33026">
        <property type="protein sequence ID" value="EFI33026"/>
        <property type="gene ID" value="Dthio_PD0340"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1974284at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8961" checksum="6F54C6C68E68E66A" modified="2010-08-10" version="1">MTKKKKKETTEPQGNLQAKYEHTKEYLEEVKGELKKVTWPTRKETLSTALAVVALVIIVSIYLGIADFIFSRLVALILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUR6</accession>
    <name>D6SUR6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871739.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0360"/>
    <dbReference type="EnsemblBacteria" id="EFI33046">
        <property type="protein sequence ID" value="EFI33046"/>
        <property type="gene ID" value="Dthio_PD0360"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033TTD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1594818at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="268" mass="31347" checksum="17E84C87F64090AB" modified="2010-08-10" version="1">MSTIEQRTEERLPLEMAILPFLGSREEDYQPFQYIIQDFSQNGVRIAIPSWLQSREKLYRGDRVNLHLPYKFQGQSRNQGSVAWETWEDQAAAQVCGVALDKSFPETYPVFISLETRELVIGLENFEDEASLLLLVLKDIAMLKRGMLIYLEHLATYFTRVSEFSREEYALFRRMIINDIKTGMQKNHDYLSSLYSKALSLHSRNQDIMEILDIDELRQSVQSEIYVDLFSSVLSIETINMYLMALKTLEKKSYNNYNTLVMLYLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUR8</accession>
    <name>D6SUR8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871741.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0362"/>
    <dbReference type="EnsemblBacteria" id="EFI33048">
        <property type="protein sequence ID" value="EFI33048"/>
        <property type="gene ID" value="Dthio_PD0362"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="209"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="555" mass="64206" checksum="9A2FABE31F098CFA" modified="2010-08-10" version="1">MSQNKTAFKNNLLLGGIVLTLMFIILYLMARTFTFIIADYAWYEKFFGLLLLLAQAFILTHGFGYFLNLFRVINSEGKTGSENHLVQASLIDYPPVAIIVSSYREPLHVVEDTLISFYNLTYPNKKIYFLDDTRYDLPDWKPGEAEKYRLEIDDLCRRIGVNLFRRRWRGAKAGMINDFNDFLDKNPPEGFEFVSYVQGETIKPGDEKYIIVFDADQKPLPDFVEALVSRMEANPAVAFIQTPQYYSNFEHNRVSRGAGLQQAVFYEYICEGKSQQDAMFCCGTNVIFRREALRDVGGFDESSVTEDFATSLKFHLRGWKSAYLNKVSAFGDGPEDLGGYFKQQFRWALGTVGLFRTILSRLWKNPSELPIYKWWEYMLSGTHYFVGWVLFVLVISPILFILFNIPTYFARPELYFMFYVPYILMTFTMFIWSLRQRHYKASEIVSGVLLQAICFPVYMKASLLAVLGYRGTFKTTPKGQSLSLPMHALWPQVGLAALCFVAIIWAGMRIYYERELIMALSVTSFWCLYHFLILSAAVYFNHPLEEGLEESVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUS4</accession>
    <name>D6SUS4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33054">
        <property type="protein sequence ID" value="EFI33054"/>
        <property type="gene ID" value="Dthio_PD0368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="57" mass="6757" checksum="6C7777D7440CCD5F" modified="2010-08-10" version="1">MLLTTVCKECKKEYSYDPRFDALAYTQGRCRECADRKGIRRVDLTRKFSERGRGHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUT4</accession>
    <name>D6SUT4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD0378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871757.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0378"/>
    <dbReference type="EnsemblBacteria" id="EFI33064">
        <property type="protein sequence ID" value="EFI33064"/>
        <property type="gene ID" value="Dthio_PD0378"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="273"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="351"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="419"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="663"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="764"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="840" mass="95119" checksum="E06EE8A5F2017B03" modified="2010-08-10" version="1">MKKSLHSTGHSAHTQDEPSQETLRKYQAIVSTVKEPMSFVDRNYVYQAVNQAYLDTFAGSRKEIVGHTVESLLGAHVFDNIVKPRLDRCLEGKEEHYESWFDTPAGIQECLSVFFHPCLDENGQIQGVIVHARNITEQKRLEEALRRSQQYYRAIFETTGTAQVIIEEDTTISLANSRFEGLSGYCRQDIEGRKSWTEFVHPQDLEQMRHFHFSRRKDDYTAPRQYEFRFIDAHGHEHHIYLCIDTIPGTTQSIASLMDITERKQAENALQESRAQLQAITDSAQDAIVLMGPEGEIAYWNPMAESIFGYTAEEIVGKDLHNILAPARYHEQHLKAFQHFQQTGRGDAIGKTIELSALDRDGREFPISLSLSAVSLQNRWHAVGIVRDITRQKDAEEKIVKARDEAEAANRAKSEFLANMSHEIRTPINGIMGMMQLLEATSLDVEQAQYVQMGLTSARRLTRLLSDILDLSRIEAGQMEIRQEEFDVRKLCFSVTELFMVTCREKNIALEYSLDPQLPEILLGDETRLQQILFNLVGNALKFTEQGRVQVNWHLMKRRERDIQVLLTVSDTGIGMTPHRAGDLFKPFVQAENAYTRKYQGAGLGLSIVKRLVELMHGEVTVESMPDAGSTFNILLPLKVPEQPEKEQQLDASESAPDNQGLRVLLVEDDPSNQLPMKRLLQKSGHQVSLAGNGQKALDMLAHQDFDCILMDIQMPGMDGMEATRRIRAAGDRRQESEIRDQRSEVREHKSEVSGLGSKEGEPIPESLNSQIPESQNSSIPESLNSPIPESPNSQIPIIALTAYAMDGDRERFLEAGMNDCLAKPVQKDDLERMLRKHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJU6</accession>
    <name>D6SJU6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869274.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3603"/>
    <dbReference type="EnsemblBacteria" id="EFI36149">
        <property type="protein sequence ID" value="EFI36149"/>
        <property type="gene ID" value="Dthio_PD3603"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="43765" checksum="7B91440DA667DD5C" modified="2010-08-10" version="1">MSIYKKQAGSALIISIVVLMLLSILGAAALRATNSELGIVRDEIMREAAFYVSESGIEAGKSYLQERLSESSLRGDSSKSFILDSEIDNIEDEEPYLSHKFENDSEYSVWFQWEDDNNNSSFQVISNGNKKDKNVQTTLTLQIDRNESDTPTPDAPFSIHTPNPKMRMQGNPLISGYDHDVPEDFLCGGNCTGLENFDSEYDSMPAIYSDNEFEYLDYQDKHLDSPVETTQIGDSALDETGIANDYWIDYANRLLPNYDRLIEHDTDVPGNDVWGDRENPQITIVDNKKLGGTIDGAGVLILKNGADITGNFHFEGIVVYMVEEGDTIDMFSAGTPNIFGSVVVAGEELSDDIYFEDEIGYLGNANVSFSSEAILNSAHNAIPPYINIVSWENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKB5</accession>
    <name>D6SKB5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869437.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3783"/>
    <dbReference type="EnsemblBacteria" id="EFI36318">
        <property type="protein sequence ID" value="EFI36318"/>
        <property type="gene ID" value="Dthio_PD3783"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1820646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036782">
        <property type="entry name" value="NE0471-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143880">
        <property type="entry name" value="SSF143880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9251" checksum="2C19195C93F64D3E" modified="2010-08-10" version="1">MIRITQARYLGDYQVELSFSDGMTGIFDGKSLLKRSGPLLKPLNDELFFQRFFVDSGALSWPHGLELSPAKLYQSCKLHKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKE0</accession>
    <name>D6SKE0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma54 specific transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869462.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3811"/>
    <dbReference type="EnsemblBacteria" id="EFI36343">
        <property type="protein sequence ID" value="EFI36343"/>
        <property type="gene ID" value="Dthio_PD3811"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="197"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="513" mass="57428" checksum="62624BD1864B8384" modified="2010-08-10" version="1">MDQNIFFREATMRICGSLDLQKAMQNTLEFISSYIPADALNIGLIDPEPGVARSVVHISPDDWPESRSTVSMPQNIVSKFTREWESKPGFRILNDISLEEPAVQELIRAFWPEDVSLLRTDLALESRRMGLLLLVAEGKNRYTKEHARIMSSLNKPFSVALANALQYEEAIQLKNMLEDYNRDLRSELSGLSADNRIVGAEFGLRQVMRMVRQVAPLESPVLLQGETGTGKEIFANALHAASLRSDGPFIKVNCGGLPESLVDSELFGHEKGAFTGAISRNRGRFERADKGTIFLDEIGELPLNIQAKLLRVLQQNEIERVGGSRTIPVDVRIISATHRNLEQMVQRGEFREDLWFRLNVFPIMIPPLRQRPQDLPALLDHLVSRKCREMKITREIRIPSGTMDRLKKRAWPGNVRELQNLVERTLIQAHADNPDSAVLNLDLAVSGQKSIETNLETSGNTQVLTFEEAAARHIKKALEVARGKITGPGGAAEILGLNPSTLRGKMRKLNISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKJ0</accession>
    <name>D6SKJ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2609"/>
    <dbReference type="EnsemblBacteria" id="EFI35201">
        <property type="protein sequence ID" value="EFI35201"/>
        <property type="gene ID" value="Dthio_PD2609"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9497" checksum="D9AD9876B238A41A" modified="2010-08-10" version="1">MKIKYSQETDILVVEFKEGVPVDSIDMKEVVILHLDSEGVPVEMEILDASKFVAMDEFNILVPMIKDKNEQRDRLILDIFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKJ8</accession>
    <name>D6SKJ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868343.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2618"/>
    <dbReference type="EnsemblBacteria" id="EFI35209">
        <property type="protein sequence ID" value="EFI35209"/>
        <property type="gene ID" value="Dthio_PD2618"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1862543at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="20166" checksum="7BD5DD4F85600989" modified="2010-08-10" version="1">MSRTVCNCKSRPFFSRGAGKVRGAAVILLALIICGFPWSALADEPRLPESILGMEKTEVMKGKEASKKVDRMHRGDVATGMDYIAEYTDGDHSATYYVSLYDEPEEAVKARQEMARKMEETSHEFSHFMQRTVNEHTVYMALAHDQAHYFFAQDMELVWLAVDISVAEDALKELFSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKJ9</accession>
    <name>D6SKJ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">Dthio_PD2619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868344.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2619"/>
    <dbReference type="EnsemblBacteria" id="EFI35210">
        <property type="protein sequence ID" value="EFI35210"/>
        <property type="gene ID" value="Dthio_PD2619"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="15209" checksum="0D194B0EC8FA0ADA" modified="2010-08-10" version="1">MKALLDTGPWVALIDRSEVAHEACVQWFASFSGELFSTEAVLTEVLYLLNFSLKAQQAALDFVIRGIVTLVPSDLYSLHFARTQMEKYADLPMDFADATLVCLAEESGILNIASLDHKDFSIYRTTGNQVFRILTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKS4</accession>
    <name>D6SKS4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General secretion pathway protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family. GSP D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868417.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2699"/>
    <dbReference type="EnsemblBacteria" id="EFI35285">
        <property type="protein sequence ID" value="EFI35285"/>
        <property type="gene ID" value="Dthio_PD2699"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="881521at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013356">
        <property type="entry name" value="T2SS_GspD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02517">
        <property type="entry name" value="type_II_gspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088222" evidence="6">
        <location>
            <begin position="18"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="703" mass="78705" checksum="D21EC9DA831ADC44" modified="2010-08-10" version="1">MKFIFLLVILFLCSSCAAMDPEIKSLAREPVAYPQKEEVPEHFEMPAVQPEPVLKPDVTEAELLNQRLQEIIAASPLGTTMDIFAPAEEFDPAEARDVSFSFYDADLVEVIRVFMQLLEEDYLIHPGVSGRVSLFVKDRFNARQMLGVLEGVLRVNNAAMIRSDQILEFLPLSRVPGHIPGELIILPDREELPRRGQIIQGFGLDFIAAQEMVNIIEPHLSGDARVYAHEEKGVLLVSDYPHSLEKVSRLISLFDESIFADVLARVYPLRYIEAGEAAQKLENILERFGMDRDRVGRQARVSFLPLERLNMVLAVTRSETVLSFVQAWVEGLDRPVPEHILGSAGENIYVYYVQYGDAEEIVESLRGVFDQGVEADSEVGREAVSEVASEDDQDVFAPGMVSGELAGPVRFTVDRATNSIITRCRAPDYARVLSVMEKLDLYPKQVLIEVIIAEVRLSDATKMGVDWQYILSFGDRLSGELRFDPAADALPGAGGVFRVESSRRLKAALYAAVDDAKLQILSTPTLLASDNRPATINIGDQVPFPTSTRQRLDDTDTSEVIDTTIQYRDTGIILRVTPKINRHGMVRMEIVQEVSSLTARRVEGITAPVINTRHAETTLAVDDQETIVIAGLMEQERSRGYSGVPGFRRIPVVKHLFGTSETRFENTELLVFITPHVIMSREDSGFLTRNFLTRLEELKERMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKW6</accession>
    <name>D6SKW6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868459.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2742"/>
    <dbReference type="EnsemblBacteria" id="EFI35327">
        <property type="protein sequence ID" value="EFI35327"/>
        <property type="gene ID" value="Dthio_PD2742"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="111"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="190" mass="21261" checksum="FC0D4E6046A0F3D0" modified="2010-08-10" version="1">MKRLALLFIMFLGVVVLQATYSWAGQAQHIRDYLLSPGDILEVSVWNDEALQRESMIRPDGMISFPLIGDVPAAGKTVRDLRKDLEDRINEYVPGTPVTVILNYINHPRMYIVGKVGTPGHYIMEKETTVVQALAMAGGLTTFASKNNILVLRQNAQEQEVFSFRYGDIENGRNLEQNIVLMPGDTIVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL02</accession>
    <name>D6SL02_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868495.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2778"/>
    <dbReference type="EnsemblBacteria" id="EFI35363">
        <property type="protein sequence ID" value="EFI35363"/>
        <property type="gene ID" value="Dthio_PD2778"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1915">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="718059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="372" mass="41645" checksum="647BFE8381C9B84A" modified="2010-08-10" version="1">MTFKLPGYCPPDLTRERFSSAPAALTAEAPGNGTAPSGFHATSNHPEYVCMEPGKWILVRESRMDCVIVRRGDSLEVLEPRRLKQGDRVVLGRTENGEDGIFVHTEGFDTGRSSAPDKFSFRIRGTRETPFSKSYDALYDLLRHDREHGYIVWVLGPAVAFDQDSRRAMQGLIRNGFCHVLLAGNALATHDLEAAMFQTGLGQDIYTQEPVRHGHYHHLDVLNTVRQYGTIKETIREMKISDGIMYTCEKYRVPYILAGSIRDDGPLPEVVADVYKSQDAMRPHAKKATTVVAMATQLHSIAFGNMTPSYRVMENGLVRPVYFYIVDISEFSVDKLANRGSVQATAVVTNVQDFIVNLSRNLDSWQQEGQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL76</accession>
    <name>D6SL76_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868569.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35437">
        <property type="protein sequence ID" value="EFI35437"/>
        <property type="gene ID" value="Dthio_PD2857"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2093232at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="63" mass="7294" checksum="54DA257D3D8B721F" modified="2010-08-10" version="1">MAGQRTIITLPDEDRTWLESYSRTYGISMAEGVRRALRMLREDQEKDVYRALVEQTRNTSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLB0</accession>
    <name>D6SLB0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional modulator of MazE/toxin, MazF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2891"/>
    <dbReference type="EnsemblBacteria" id="EFI35471">
        <property type="protein sequence ID" value="EFI35471"/>
        <property type="gene ID" value="Dthio_PD2891"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="11604" checksum="8D7A6ACDACF45141" modified="2010-08-10" version="1">MRGSIVLLPFPHTDLSTAKIRPALVLKKLDGSDAILCMLTTNLSSKHAIKISQKDVKQGTLKKECNVRPDRLFTADTETFIDKVCTLNDVKMEEILQQVTSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLC7</accession>
    <name>D6SLC7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868620.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2911"/>
    <dbReference type="EnsemblBacteria" id="EFI35488">
        <property type="protein sequence ID" value="EFI35488"/>
        <property type="gene ID" value="Dthio_PD2911"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1915735at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="13"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="24354" checksum="1E61E678C05E8F76" modified="2010-08-10" version="1">MDFTLDTSFLYPLQLTLKVASLATFFALLLGVAAALVIHKYRFFGRDLVDSVLTLPLVLPPTVLGYYLLVVMGRNSFLGRWLEDSLGISLVFTWQGAVVAATVVAFPLVFRSTRSALENVNPSYENAARTLGCSEPNVFFRVSLPLAMPGILSGTMLAYARAMGEFGATLMVAGNMPGRTQTMPLAIYSAVQSGNNALANSLVVIISVVCIIILWTSGKLLKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLE4</accession>
    <name>D6SLE4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868637.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2929"/>
    <dbReference type="EnsemblBacteria" id="EFI35505">
        <property type="protein sequence ID" value="EFI35505"/>
        <property type="gene ID" value="Dthio_PD2929"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="463" mass="49529" checksum="BD99D17040D334E0" modified="2010-08-10" version="1">MSNESLQKEFAKVVGQDNVMTSESEMHAYSYDSAVLDQVSPAMVVRPTSSEALGQVVKLCNDNELKLTVRGAGTNLSGGTIPHPGGIVCLTTALNNILEINEEDLYAVVEPGVITAKFAAQVASKGLLYPPDPGSQAVSTLGGNVAENAGGLRALKYGVTKDYVMGVDFFDVNGELVKSGSRTVKCVTGYNLAGLMVASEGTLGVFEKLILKLVPPPKAIKSMMAEFDDVAAASQAVSAIIAAKIVPATLEFMDNFTIKTVENFRGAGLNTEAAALLLLEVDGHPAQVEDDAAQVQEICNKLGARQFTVAQDAKQRDAVWQARRDALPALARVKPTTVLEDATVPRSKIPDMMQALKRIAREYKLTIGTFGHAGDGNLHPTILTDKRDTQEWERVEKAIDEIFDVALDLGGTLSGEHGIGIAKSKFMHQEHGLAAIEYSRRMKSVLDPKDILNPGKMLGPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLK4</accession>
    <name>D6SLK4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2991"/>
    <dbReference type="EnsemblBacteria" id="EFI35565">
        <property type="protein sequence ID" value="EFI35565"/>
        <property type="gene ID" value="Dthio_PD2991"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="90"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="212" mass="24601" checksum="87F1B05F120C744C" modified="2010-08-10" version="1">MRKVIIFTDGMFMRRRVLERNHFLYKPREIREYCQKHLRQKDYLVRIYYYDCRPLQARGTSPLNGKEIDFSRLESARLRHQLFEGLRHAPNFCLRLGNMEWNGRDWNIVGSKVSPLLKKEITVDDLSDSDIRPGSETTQISVKMALDMTTLAARKAGDMFVLITDRSDLVPAMEMVRQEGVQICLDNMHAPVSSELSEQADFISTNLGNKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLL0</accession>
    <name>D6SLL0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP-like extracellular</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868703.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2997"/>
    <dbReference type="EnsemblBacteria" id="EFI35571">
        <property type="protein sequence ID" value="EFI35571"/>
        <property type="gene ID" value="Dthio_PD2997"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1625525at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="330"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="570" mass="63035" checksum="997B9302B87FB9B9" modified="2010-08-10" version="1">MGLNGRLRYNLPTGVTADTIWFQVKVDEEPVDTAVGNGWVRGDRLGDEYFTAERGGKELGVTPFFDGALQEGLSQEWTVQGESAAELKINFMNITPEEPEPGQEFSVDVNIEELADVETENLTVDLTIAGTEIEETIDVDSLQGTETTVTFEDLVIEDAGEYTIDVTADADNADIVSSQSTLNVSIEDFVVGIEITTQPDLEYIEGQELDLSDLEVTKSYQVAEDQVVSFSDFADYGLVVDLAQGTELTLGNDDQTIKVEHTPTEKTAETQPLSVSTQEVESHFPTDYEQYMITLINRARLDPEAEADLFGIDLNQDISPEDEISPDMKQPLAFNPDLTQAAREHSQWMLDNDTFDHTGEGGSSVEDRIKDTDYNTDPPWGWGENLALTGYTEGMDELIAQKHENLFLSSGHRENTMSESFMEVGVGSLLGDYANNTVYMSTVKFAHTSDTPFLTGTVFQDLDDSGAYKPGEGLGDVQIQVGGQGTTTWDSGGYAMQLEPGDYLLTFNHDKFEEKVEMDFTMPDENVLVDLVLEPDDLQNRTESSEPSIQEIQFMGVEKEDDTFGVSEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLR5</accession>
    <name>D6SLR5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868755.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3055"/>
    <dbReference type="EnsemblBacteria" id="EFI35626">
        <property type="protein sequence ID" value="EFI35626"/>
        <property type="gene ID" value="Dthio_PD3055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="1">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10799" checksum="1501490DA9D15E1F" modified="2010-08-10" version="1">MQEIKITRNPPREELEKMGVWQWPTWGEKESEFPWHYDQQETCYIVEGEVEVTPEDGEPVVIKAGDLVTFPRGMSCTWKINRAVSKHYRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLR7</accession>
    <name>D6SLR7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3057"/>
    <dbReference type="EnsemblBacteria" id="EFI35628">
        <property type="protein sequence ID" value="EFI35628"/>
        <property type="gene ID" value="Dthio_PD3057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="573" mass="66662" checksum="B4DD05F9879A5B46" modified="2010-08-10" version="1">MKNKPVSEVCNEFSLGTLGLPEFSRVLEHGYVPEHSARFMRAMSCGEPFIVRDHLFLAGGDWLMAVGYPLTGPYHPQSFSEALRESIKRIRPARCWSVSPALPEDLSGHCVEQDFYYILPVESRVQSRLLRLAQKASRSLEVEQGREFTPAHEELWKEFVHNRTLPARVRNMYQRTVHVLAGVPELFLLNAWDENGNLAACLLLDPGPKRFVSYLIGAHSRINYVPYATDLLFREMIELSRDRGKEFIHLGLGVNPGIRRFKVKWGGTAHWPFEFAAWEEKPEAHKESKVHPVPFMEDKFKFFLNLPEQRRLAMIWELEKNGRRSWIAGAAHFYPYSFRLDMRRLFQEVDTVLCEGPLDQVSMDIIADFGKNPDPDTPRLSSMLTDSEIKNLEKVVLGRNFWSRLLNMSLENGPDVRYYLAYTKPWLAFFTMWSSFLRRHGWEQSVDREAWDTAQEMGRYVLGMETISEQLRTLDSIPVDRIVRFFRDCHNWSGLKKRYETGYLKGELDRMFGTSAEFPSRTEMVINRRDERFLSRMLPFLEKGGCAVFVGSAHMLNLRSMLREAGFSVHRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLR9</accession>
    <name>D6SLR9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868759.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3059"/>
    <dbReference type="EnsemblBacteria" id="EFI35630">
        <property type="protein sequence ID" value="EFI35630"/>
        <property type="gene ID" value="Dthio_PD3059"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="312"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="589" mass="65629" checksum="291F1EAC2D87EB5B" modified="2010-08-10" version="1">MKFVNIFSRSILLKVVVLVVLLAIVVFTLLILVNSYWQRADTMSQIESQGYRTTDLVELNIEEPMLIGDNEGTHQQFARIDDLYDDLNVYLTDFRGNITYSTSEDNLRMDMDEVHPEPDVHQVVFDSLDRETEESAMVTAGGTTYFMTVRSIPNEPECYHCHGSSQPILGSMLVMQDIDPDLALLQRHQIQNALLGLGCLLILVFSMVYFLRKTVINRITYLHDMETRVSKGELDLEFQDLGEDELGRLNQGFKEMVQNLKQKISESQEKTRMAEEQTREANLAMEEAAEARDAAEERERSLQEAAAQVQSITSELTQFTEQLASQVEQASRGAEEQSRRTTETATSMEEMNATVLEVAQNASRSAEESTQAQETARSGEKTVHEAVKAIATVQRNALGLKKQIVTLGEHAEGIGKIMNVIDDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMKATQEVSQYISNIQEEVHKNMDSVDNTVESVKGATKQANESGKQLSQIVKLVKRANEQVQAIATATEEQSTASEEINKNIEEINRISKETAGVMNQSAQAITDLNKQTQKLQSLVDKLQKSSQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLS4</accession>
    <name>D6SLS4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">Dthio_PD3064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868764.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3064"/>
    <dbReference type="EnsemblBacteria" id="EFI35635">
        <property type="protein sequence ID" value="EFI35635"/>
        <property type="gene ID" value="Dthio_PD3064"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="347" mass="37567" checksum="40C431C9A070CB28" modified="2010-08-10" version="1">MFFRRELAIDLGTTNTLIYSRGDGIVLNEPSVVLLDKRRKEVLAIGQKARDFSGRTHPNAISMHALSHGVISDFEVTQIMINSFIRQVLPGKSLFKPFIIVGVPLEITQLDKRAISEAIRLMGAKKVRLVNELMAAAIGAGLPTAEAEGSMIVDIGGGTTEMGVISLSSLVVYKSIKVAGDDINEAIQRHMRENHRLLIGEIMSEKIKCEIGRAVFVNDDLAMEVQGKCLIKNTPKSITLNSHEVTDAIQNSLDTIAQNIIEVLSVTPPSIAGDILKNGIHLTGGGSLLNGMNHFIAQQTSLKVISDDDPFTAVIRGAGMILDNQDNFEDAFLIVPDSKLDTQSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLZ7</accession>
    <name>D6SLZ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868837.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3137"/>
    <dbReference type="EnsemblBacteria" id="EFI35708">
        <property type="protein sequence ID" value="EFI35708"/>
        <property type="gene ID" value="Dthio_PD3137"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02038">
        <property type="entry name" value="FlhG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033875">
        <property type="entry name" value="FlhG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="11"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="272" mass="30160" checksum="3B556C6F68FCDAA0" modified="2010-08-10" version="1">MKHQNRTLSLSIVSGKGGVGKTNLSLNLAYALFQTAQNTLLVDCDLGLANLDVMLGISPEKNLNDILDKEARAEDIVYSLEDNGLGLIPAASGVTDILDLDEDQQMQIIQRMENLLYKYNFLLLDVGAGISRTVRAFCQMTHKQVVIITPEPTSLTDGYALIKVLHTRQKIDDFHILVNMVDSEKEARLGFERIRAACAKFLQLEVGYLGQVQNDPAVLDSVRKQTPFFKLSPRSRASRDIMNVAEKLTQLRSDAMESIASVPPLRMGEPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLZ9</accession>
    <name>D6SLZ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">Dthio_PD3139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868839.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3139"/>
    <dbReference type="EnsemblBacteria" id="EFI35710">
        <property type="protein sequence ID" value="EFI35710"/>
        <property type="gene ID" value="Dthio_PD3139"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1921631at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="284" mass="30912" checksum="F70302C8ACC6D5B1" modified="2010-08-10" version="1">MKPLSSNMQQFFKMQGSGNDFILWDNTSLNLPGELMSRWAETLCPRGFGIGADGMIFLDNPRTQGHDFDWHFFNADGSRAEMCGNGSRCAARLAHRLGLAGREQVFGTDAGAVRAQVKDKGKVRVQLTPAENLQLHSILNFEESSPVNLHSVNTGVPHAVIICDDVHKVNVSGLGRMVRMHPDFAPAGTNVNFIQVKDRGHIYLRTYERGVEDETFACGTGAAASVVVASALGLCANSVQVVTSGKEHLNIDLQEQGVFLTGKADFIYQGMLFLDTFGLKIPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM09</accession>
    <name>D6SM09_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SurA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868849.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3149"/>
    <dbReference type="EnsemblBacteria" id="EFI35720">
        <property type="protein sequence ID" value="EFI35720"/>
        <property type="gene ID" value="Dthio_PD3149"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="190"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="326" mass="38427" checksum="B73030898E57CCB1" modified="2010-08-10" version="1">MVKTNKSLSCRAYFFFNRSLILLAAVLLVLVSFRPAEASSVNRIVAHVNGESITLFDLEKRVEMFLGLFEDISLDELPPVQQEETRRHVLEQMINDILMRQEAERYQIEVRNREIQEHIERVKQNNNMNQEEFEQHLRAQGLSLEDYKDQIRDSMLRQRVMNIMVQRKTVVTSDRIKEYYEDNIQDFKKERKVHLKVLVVPRVEEAETLLDKIKEGEYQFAEAAENYSQGPGASEGGDIGMVRWDRMRPEWREALKNMEAGEISEPFAMQGQGVLLRVEEIHDEGAVPLEEVEEEIRDELFDKMLEKRFDEYIQGLRDRAVIDIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMB8</accession>
    <name>D6SMB8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868958.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3265"/>
    <dbReference type="EnsemblBacteria" id="EFI35829">
        <property type="protein sequence ID" value="EFI35829"/>
        <property type="gene ID" value="Dthio_PD3265"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="301" mass="32127" checksum="8D3D59547D5B3A44" modified="2010-08-10" version="1">MQFFFEQLINGLAVGGIYALIALGYTMVYGVMRLINFAHGDLFTIGAYLGLTVLTSVAVTAYLGPFLGVILLMMIIMCMVGVVGVVLERVAYRPVRQADRLSAVVSALGASIFLSNLVMLIWGPRFRVYPDDILPRITLNILGLDVPLMRILVLLASLILMGILYYFVQKTKTGTAIRAVAIDHGASRLMGINVNRIISLVFLIGPALGGAAGVMVGLYYGQINFTMGWAFGLKAFIAAVLGGIGNIPGAMIGGLLLGVIEALGAAFISTAWKDGIAFIVLILILIFRPTGILGERVADKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SME3</accession>
    <name>D6SME3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35854">
        <property type="protein sequence ID" value="EFI35854"/>
        <property type="gene ID" value="Dthio_PD3293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="34" mass="4019" checksum="0BA6726FAF3585AF" modified="2010-08-10" version="1">MCRIFLLLKKIQAGLNIRWALINRHQSTLDNIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMG4</accession>
    <name>D6SMG4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="13">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="13"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869004.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3314"/>
    <dbReference type="EnsemblBacteria" id="EFI35875">
        <property type="protein sequence ID" value="EFI35875"/>
        <property type="gene ID" value="Dthio_PD3314"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="615" mass="68030" checksum="BA73B992EC26FB1A" modified="2010-08-10" version="1">MPGINLQDLQNIREANRHRVEFTRKTCLMLCGGTGCRSTGSLEIKEALLEELNTRGLQDTVDVVETGCNGFCARGPILVVQPHDIFYQMLTLQDIPELVQEQLVNNTPLQRLQYKDPDSKQILPRQQDIPFFAHQLPWVLRNKGIIDPESIDQYIARDGYFAAARALTEMAPEDILQEMQKSGLRGRGGAGFPVHLKWKFAYRETSGVKYVLCNADEGDPGAFMDRSILEANPHSVLEGMLIAARTINADQGFIYCRTEYPLALERVQIAIDRAREYGLLGSDILGSGFGFDLEIYQGAGAFVCGEETALMRSIEGGRGMPRPRPPFPAQKGLWDRPTVLNNVETLANVPLIIQAGGDWYAGVGTRHSKGTKVFALSGDVRNIGLVEVPMGTSLRSIIYDIGGGIPGKREFKAVQLGGPSGGCVPAEYLDLPVDYEAISRAGAIMGSGGMIVMDQRTCMVDMARFFMDFVQEESCGKCTPCREGTMRILEILDRIRAGEGVIQDLWELEDLSATIRDSSLCGLGQTAPNPVLSTLKYFPKEYEDHIRNKKCPARKCIALVKFRVNPDKCTSCGLCHKNCPSGAVRWKKKQPAEIDPQKCIKCMLCLDKCMFDAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMN4</accession>
    <name>D6SMN4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869073.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3387"/>
    <dbReference type="EnsemblBacteria" id="EFI35945">
        <property type="protein sequence ID" value="EFI35945"/>
        <property type="gene ID" value="Dthio_PD3387"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="28"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="380" mass="41722" checksum="5DB3AF91D690C772" modified="2010-08-10" version="1">MPRILKYLALAFLLVSLASAVIILNRSPVVVGFAGPLTGPYSDLGVNGRNGARLAVEEINARGGIDGRKMELLVRNDKGLCDEAAQATAELIDSGAQAIIGHMTSQQTISALPVAAKEDVVLLSPTTSTPKLSGIKDNFFRIQPSTDQHAIALARYVFHEKEIDTLCTLRDMDNEIYADSFEKHFVQEFKSAGGEVTNRKKLYASRSQDWLQIADDLQLCSEQGLFLAVSGRDAVNLVQAIDNTGLSPDIFSSGWAMTRELLRAGGRTVENMTFVTTTSQENLGTDYYEFAKNYRSRFGSEPSFAAAMAYDAAHILALALEESSGDRGLEQALTEIRDYPGLYWPITIDEYGDVTSPVTIVQVREGEFEEVYSFKAEDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMP5</accession>
    <name>D6SMP5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Flagellar biosynthetic protein FlhB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">flhB</name>
        <name evidence="15" type="ORF">Dthio_PD3398</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the type III secretion exporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869084.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3398"/>
    <dbReference type="EnsemblBacteria" id="EFI35956">
        <property type="protein sequence ID" value="EFI35956"/>
        <property type="gene ID" value="Dthio_PD3398"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1424100at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006136">
        <property type="entry name" value="FlhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00328">
        <property type="entry name" value="flhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 13" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI35956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="359" mass="41100" checksum="2EC37449A2F1F9A2" modified="2010-08-10" version="1">MPQKDPSKTEDATPKRRKKAREQGNVPKSQEMPKIISLIAGILALRLFFPHIRDTYMEMTEWFMDQAFHYQLNPESLYHLAVFSIQNIASMLLPFMLIVFFVTIVAIYLQVGFLWTFKPLKPKMKIFNVVEGLKKKFLDLNTLVRLVKNVGIASAVATAPYIIITSEFENFLPLFYEDPPFIVAYILNTAFKMAMLAMIPLLIIAIADVAYTRWDYEQNLKMTKDEVKDERKQAEGNPEVKKEQRKKMQSTTQQRMRQEVPKADVVITNPTHLAVAIKYDPVLAPAPMVLAKGANFRAEKIKEIARENNIPIRENKPLAQALYKNVQEGETIPEDMYKAVASILAQLYKFKKQGSPGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMQ4</accession>
    <name>D6SMQ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869093.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3407"/>
    <dbReference type="EnsemblBacteria" id="EFI35965">
        <property type="protein sequence ID" value="EFI35965"/>
        <property type="gene ID" value="Dthio_PD3407"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZR0H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2010644at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11941" checksum="E1233B2D862B3123" modified="2010-08-10" version="1">MRIFGPGYRQSQEDSPGENPRVRRFRRKYSQGDVIEGTVLEYDSSQLAWVLVDDLRILAWTRNNHFRGRLLHLQVESMHPEIVLKEVEYDPEGKKRISIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMU4</accession>
    <name>D6SMU4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trmL</name>
        <name evidence="6" type="ORF">Dthio_PD3447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869133.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3447"/>
    <dbReference type="EnsemblBacteria" id="EFI36005">
        <property type="protein sequence ID" value="EFI36005"/>
        <property type="gene ID" value="Dthio_PD3447"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1578095at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="153" mass="17617" checksum="883720CFE6D79EE7" modified="2010-08-10" version="1">MHIVLYQPRIPPNTGAIARLCAATRTPLHLVGPLGFSLDDKYLKRAGLDYWEHVELTLWKNWEEYRQNLDKSHRLIMTSARQGADYTRHSYSFQDHLILGPETWGLPEKITSQADHLIRIPIWGEVRSLNLSNAAGIILYEGYRQLGMPPAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMY2</accession>
    <name>D6SMY2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869171.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3486"/>
    <dbReference type="EnsemblBacteria" id="EFI36043">
        <property type="protein sequence ID" value="EFI36043"/>
        <property type="gene ID" value="Dthio_PD3486"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2102860at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="155" mass="16661" checksum="8B0A1A21D4C80C1E" modified="2010-08-10" version="1">MDWMLWLFTALILVLVDVILFGGASGILLALGIMALIGMVCALAGISWEWQILSAALSGFIIVPVALKILRRTTPGQLLHGVEDPRIRGRSFQIHIDSTGKPRINVLGDSYPVRMEDGNGGLESGSAVNIVRFEGVTAVVRPAARTGTYDSKNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN29</accession>
    <name>D6SN29_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3537"/>
    <dbReference type="EnsemblBacteria" id="EFI36090">
        <property type="protein sequence ID" value="EFI36090"/>
        <property type="gene ID" value="Dthio_PD3537"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2191624at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="145" mass="17280" checksum="F764357229427A36" modified="2010-08-10" version="1">MDPIEDITRDEWQEFYEIFPAIYFALAYVSRYGTDMHWIEKIALTEPNGVPDFPGYDLWLKRKAFIFSIKHNGISFLLDNINPYTRPLPAYYCFLRLKEAQINKQEIIQALKFQINQSVTPGEYADHAREYIEKMDNMIFFDGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-04-22" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN35</accession>
    <name>D6SN35_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869221.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3544"/>
    <dbReference type="EnsemblBacteria" id="EFI36096">
        <property type="protein sequence ID" value="EFI36096"/>
        <property type="gene ID" value="Dthio_PD3544"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88435at68525"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="16292" checksum="3DFF8A76E0E64FAA" modified="2010-08-10" version="1">MNQEKKTKEKFWTKIWSNRSKGNFVLSDHEITHVKKLPGGWLLRHRFMAGKQFSRSGIIFIPDPEQIWKTDQIETKWERIFTERTPNYIAYTSRMKTPQGWVMKELLSTKRPFSREGTNCLTLTYIEDRDHQWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN64</accession>
    <name>D6SN64_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0004</name>
        <name evidence="2" type="ORF">Dthio_PD0093</name>
        <name evidence="3" type="ORF">Dthio_PD0482</name>
        <name evidence="4" type="ORF">Dthio_PD1539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32722">
        <property type="protein sequence ID" value="EFI32722"/>
        <property type="gene ID" value="Dthio_PD0004"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32795">
        <property type="protein sequence ID" value="EFI32795"/>
        <property type="gene ID" value="Dthio_PD0093"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33159">
        <property type="protein sequence ID" value="EFI33159"/>
        <property type="gene ID" value="Dthio_PD0482"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34190">
        <property type="protein sequence ID" value="EFI34190"/>
        <property type="gene ID" value="Dthio_PD1539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="40" mass="4411" checksum="F9309DB82660D23C" modified="2010-08-10" version="1">MNEKNSGGVKKKSGISAEYWSLTTEHSGNCLKGGVYVYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN87</accession>
    <name>D6SN87_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhamnosyl O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rhamnosyl O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869541.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1564"/>
    <dbReference type="EnsemblBacteria" id="EFI34213">
        <property type="protein sequence ID" value="EFI34213"/>
        <property type="gene ID" value="Dthio_PD1564"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831745at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007072">
        <property type="entry name" value="Rhamnosyl_O-MeTrfase_CmcI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04989">
        <property type="entry name" value="CmcI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="265" mass="30222" checksum="A563D91DB6E9A9D8" modified="2010-08-10" version="1">MRGEKDPVQLFEQEKKERIAGYGRDPEFNALSRKWFQESMRRRYPYNFNWLGRPVIQYPTDVFALQEIIYSVQPELIIETGIAHGGSIIFSASMLELVSLCGGREGEVLGIDVEIRPHNKKAIQAHPMSRRISMIEGSSILQEVATQSLQHAKDKSPVLVILDSNHTHEHVLAELEIYAPLVSPGSYCVVFDTHVEDSEEDLFPQRPWCRGNNPKTAVYEYLRCLREEGRTAQDGGVLRMEVDEVLESKLQITSAPEGFLRRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SND3</accession>
    <name>D6SND3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869587.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1610"/>
    <dbReference type="EnsemblBacteria" id="EFI34259">
        <property type="protein sequence ID" value="EFI34259"/>
        <property type="gene ID" value="Dthio_PD1610"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="364" mass="38571" checksum="F146C63F83B531FD" modified="2010-08-10" version="1">MSKWLKSPWLELNIMIALAVLSYGVLAVAAPFVPVPEGGMPGGVLVGWLVGFFIASTIIAILATIGGIGGGVLFTPLVMAFTPVDSVIARGTGLIVAMFSGLMATGPVMRSGLANLKMCIFLCVAFAVAAFSGAQGAVIVAAHLGDFGEGLVRMMLGLLIGGLVVYFIMGGKKVEWPDVKKSDKITEALNLRQPFYEPSLKKVVDYGLTNMGWLFAAILIVGLVSGFFGMGAGWAMVPFQNVVAGTPMKVAAANSVVLLGMGDCVAVWPYFIMGALIPMFAAPWLAGQVVGGLFGALVLVQIKAGFVRWLLIGLMGFSCWGLITRALSMWEVIQPPPHWLNFTVLGVLMLFVIVNVARELKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNE2</accession>
    <name>D6SNE2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylylsulfate reductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869596.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1619"/>
    <dbReference type="EnsemblBacteria" id="EFI34268">
        <property type="protein sequence ID" value="EFI34268"/>
        <property type="gene ID" value="Dthio_PD1619"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011802">
        <property type="entry name" value="AprB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022738">
        <property type="entry name" value="AprB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038465">
        <property type="entry name" value="APS_reduc_Bsu_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12139">
        <property type="entry name" value="APS-reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02060">
        <property type="entry name" value="aprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="164" mass="18518" checksum="76CC1CC41EFEB4E7" modified="2010-08-10" version="1">MPTFVNPEKCDGCKGGEKTACMYICPNDLMILDPEAMLAYNQEPDACWECYSCVKICPQGAIEARPYADFAPMGGTSIPMRSGTDIMWTIQFRNGNIKRFKFPIRTTEEGSIKPYEGKPEAGDLENELLFNETELKKPTNVINQKVEIKNADYTETWKNPAVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNF8</accession>
    <name>D6SNF8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Dthio_PD1635</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869612.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1635"/>
    <dbReference type="EnsemblBacteria" id="EFI34284">
        <property type="protein sequence ID" value="EFI34284"/>
        <property type="gene ID" value="Dthio_PD1635"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029150">
        <property type="entry name" value="dCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14827">
        <property type="entry name" value="dCache_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="20">
        <location>
            <begin position="344"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="19">
        <location>
            <begin position="467"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="555"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="808"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="955"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="21">
        <location>
            <begin position="1116"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1078"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="504"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="862"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="1004"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="12">
        <location>
            <position position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFI34284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1209" mass="136178" checksum="4D19DBF50DE29601" modified="2010-08-10" version="1">MRIQSKIFIPLILLVLFFTSVAFYASTLQRGHMEKSGAERLALENQDKIDQVVSIMELSAREQAAMFSAHPLVRESLETAAEGDMDDPYDLRVQEAREFLRHGLQDFMQGYSRMLGEDKPLRLHFHLPNGRSLLRSWRDKNVLLNGLQEDRSDDLTQFRGTVNRVMETREPVSGIEVGRGGLVVRAVLPVFSENGEYLGSVESLSRFSDVWEDLELKHVSHLNMFMKKEWLHLAPEMQDRDTYPRLNENYILAAGEGEEEIMQALNVQDLEQGEQGLQVRIEKGYAVAAFPILDYAGNAVGVSAQYLDVSQQQFRLAWMNRLLWGTPLAIMLVFLLVGRKVVQQSVIEPISRIREQIQGIQENKESLGRRLDPGSRDELGQLTSDFNRLMDRYHEMLTFNTMVLDAIPDPVFVVDSNMHIMHANRATMDLAEEHDPEELRYYTCRQIFNADCCGLPECPIATLQRGEDVDTRQIIRWDRGEGRVMYIRPRAKVLRDREGNIAGYLELAQDVTALMEKEQDLEQKNQELMVLNEKYQEAARQAREASRAKSEFLANMSHEIRTPMNAIMGMTELAGNTELTPEQKEYLSIIQNSSESLLALLNDILDFSKIEAGKLDLEYIDFSLRETVHNAVYSVAMLAHQKGVELVVRVEPDMEDGFKGDPDRLRQVLVNLVGNAIKFTQQGEVQVEVRLAAAEEMLQHAARDEGYLSKLQILFRVVDTGSGIAWDKQEGIFEAFVQADGSSRRKYGGTGLGLSISSRLVEMMKGRIWMQSEPGRGSTFSFVLPLEPGEDAQKEQVLGDVSQLQGLKVLIVDDNANNAGILEESLRYWWMQPAIAQSGGQGLKMLEHAASANDPFQVMLLDMHMPEMNGLDVLEAMQDMDPSVKPVILVLTSGAQLGDSRKLRTYGVKAYLFKPVKQSKLLGAILDAVSGGMDHEQEQAQEGKGEEIDGLRPLKILLAEDNEVNQLLAVRILSQEGHQVRGVHDGREAVDALARENFDLVLMDVQMPVMDGLEATRLIRAREQEEGLLRTPVIAITAHALKGDREKCLEAGMDSYVQKPIRKADLFKEIKAVLGEHSGRSQEEMEEAGENMSKDPGLQSPAAADLETALARMGDDQELLAELSENFLQTYEGYMQRIRKAVEDNDPGSLTHSAHTLKGMLGIFVADVAWETARKLEHKGRSQDMQGVEDLLTELEREVEEVTRELKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNI1</accession>
    <name>D6SNI1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869635.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1658"/>
    <dbReference type="EnsemblBacteria" id="EFI34307">
        <property type="protein sequence ID" value="EFI34307"/>
        <property type="gene ID" value="Dthio_PD1658"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065963at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088251" evidence="1">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="110" mass="12321" checksum="0641BCEEDF9E90C6" modified="2010-08-10" version="1">MHLVVPGLKHIFLLAMLLTLSCTQQPDMAGTYTEKNGATSGMSSVIKLHPDQEGSWKTEIDTITFKWRTTNGEIHFQTRAMDTLAGELTDTGFTIRLPHNETLEFEKNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNL5</accession>
    <name>D6SNL5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulf_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869669.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1692"/>
    <dbReference type="EnsemblBacteria" id="EFI34341">
        <property type="protein sequence ID" value="EFI34341"/>
        <property type="gene ID" value="Dthio_PD1692"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1104816at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026366">
        <property type="entry name" value="Seleno_YedE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04112">
        <property type="entry name" value="seleno_YedE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="220"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="362" mass="37466" checksum="0B6C08ACFDEA3D96" modified="2010-08-10" version="1">MSSRNIFATLAGIVAVGVIIGILAPLLQYLGNPANMGICVACFERDIAGAIGIHRAAVVQYLRPEILGFVLGALAAGLIFKEFKPSGGSAPMTRFVLGMVAMIGALVFLGCPWRAILRLAGGDGNAVLGLLGLAAGVYIGTLFFRKGYNLGRSYKQSIATGLMLPGIMLGLLALRLIFPPLEGEDKSGVLFYSLSGPGAAYAPLAIALAIGLAVGFLAQRSRFCTMGAIRDLILFRQTHLMAGFLALLVVAFVVNLALGQFNPGFEGQPVAHNLFFWNFFGMLVAGLAFALAGGCPGRQLFMSGEGNSDAAVFVLGMIMGAALAHNWGLASSPAGLGDNGAVAAIIGLAVCLAIGFANLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNR8</accession>
    <name>D6SNR8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, Csy4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869720.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1747"/>
    <dbReference type="EnsemblBacteria" id="EFI34394">
        <property type="protein sequence ID" value="EFI34394"/>
        <property type="gene ID" value="Dthio_PD1747"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503360Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1776101at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013396">
        <property type="entry name" value="CRISPR-assoc_prot_Csy4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042564">
        <property type="entry name" value="CRISPR-Cas6/Csy4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09618">
        <property type="entry name" value="Cas_Csy4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02563">
        <property type="entry name" value="cas_Csy4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="197" mass="22528" checksum="60CC3110B76A4CDC" modified="2010-08-10" version="1">MQPLYYMDIEIKRPKVEADSPIYTRIEKIFSRIHLRIKEGYKFAVAFPSMLSLPGLGDSIRVFGETREDLWGLEDYLGGAPNFEYEYIATNSDVAPVPDERVVGYEYYARFRIPSKKNSKRFSENLEAHQKQQQLRQKRLKIAASLPFVNVTSKSTARSFKLFVEKGACTNGLHGSPDGYGLSRQGNIISLPVFYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNU2</accession>
    <name>D6SNU2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34418">
        <property type="protein sequence ID" value="EFI34418"/>
        <property type="gene ID" value="Dthio_PD1776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="57" mass="6673" checksum="F4030DE100EF94B5" modified="2010-08-10" version="1">MVTIVLYHLNLIWIFGKTLCGLNHCLLFILCRVPRKMNCYQDHHSKTAPMNQKRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNV3</accession>
    <name>D6SNV3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869751.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1787"/>
    <dbReference type="EnsemblBacteria" id="EFI34429">
        <property type="protein sequence ID" value="EFI34429"/>
        <property type="gene ID" value="Dthio_PD1787"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="498" mass="55312" checksum="7C1E582C90EE43D3" modified="2010-08-10" version="1">MKEKPILVTGASGYIGSRLIPMLLYKGYRVRGMVRSRPRLDCKTWINHPALEVVEADLMDPASLAGALAGCSAAYYLVHSMSPTVQDFAAADREAAANMARMAEQAGLQRIVYLSGLGEDQPSLSKHLRSRAEVGRILKKSSVPTTIFRSAVILGSGSASFELIRFLTERLPVMLTPGWVRTRSQPIAVSNVVEYLAGCLEKPQTMGDTFDIGGPDILSYEDLFRIYAQVTGLNRRVIIKVPFLTPGLLARCAEKITPVPATLSQPLIEGMRNTVVCKDHRIREIIPQNLLTVRQAMVRSMQILCRDRIQASWTGGERPNPPEWYTCGDIYFAAGSKLKSSFRVVLKGGSYDFWPLVESIGGLQGWYGTDALWRIRGVLDRLAGGYGLQHGRSHQERLITGELVDFWRVLEVKPPKVLLLLSEMKHPGEAMLEFYLRDIPGGRLEVVLTVQFLPRGLGGVLYWHISRRVHNLVIRSMLINMVRQSGCTLLEGPDITAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP24</accession>
    <name>D6SP24_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBA/THIF-type NAD/FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1859"/>
    <dbReference type="EnsemblBacteria" id="EFI34500">
        <property type="protein sequence ID" value="EFI34500"/>
        <property type="gene ID" value="Dthio_PD1859"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="54"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="268" mass="28873" checksum="6BE34F65F7DD2EC8" modified="2010-08-10" version="1">MSYVSNMIQQPIQTYISDREIFNRAHKSGNIVQEEVLLAMEAGEIPLRYQRNNHALSLTDQISLARSAVLLVGCGGLGGNLCEYLVRMGVGKIVACDPDVFEESNCNRQILATSETLGQSKALAARQRALAINPLVEVVAVEDFVRFDLLDSVQAVADCLGGADYRQELLEMARIADLPLVSAGIAGWHALVCTTWPGESGIGEFMGKAANSVEDEQGVLAPVASFAASLQAGELVRIMTGVSPILRGNLLMADTARMRFSTVDLDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPF1</accession>
    <name>D6SPF1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1999"/>
    <dbReference type="EnsemblBacteria" id="EFI34627">
        <property type="protein sequence ID" value="EFI34627"/>
        <property type="gene ID" value="Dthio_PD1999"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="100"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="597" mass="69001" checksum="CA9DD577F1E4D9AB" modified="2010-08-10" version="1">MFLKVVSYPYLTPLFTAFFLIFTLASCKGDIPPLDREEHDLPRDAEVSRAEPGNYGGVLVTAESQQPRTFNPLVAEDAYSSEAIGRFLNGLTTYHPIKEKVVPELARSWEISEDKRTITMELRRGVRWSDGEPFTADDVIFTFKALFDERYPNRYQGQYTIAGEPIEFEKLDRYTVRFKTARPYSPFLYVIGFIGILPRHVHFDAFERGELLQQWSVRTAMHEPRELVGTGPFRVRSFRPGQRIIYEPNPHYWRVDSQGQRLPYVDYLITRYVQDRNTETVLFASGQIDVASITPGDVVGVRKNASLHDYTVHHRGPATGIRFLWFNQKPGESEAGKPYVEPHKLEWFTSRKFRQAILHGFNREGLIQSVYFGRAELLHSIISPANERWHNPDVPKYHYDPDRALELLQEEGFEPDEDGNLVDSQGNQVSFQVYASEGDDITPQILSTFRENMRDLGISVRIRYLDFGTLVARVSRHFEYEGAMMGFTGGADPSGGRAIYLSSGRLHLWNPEQEEPQTDWEARIDELVYASEETFDLDERVDYVHRMQEVFSEELPLLYLVTPHAYVGLKDRWQNVRIPSMGSAIWNIDELYLDPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPI6</accession>
    <name>D6SPI6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH/Ubiquinone/plastoquinone (Complex I)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869982.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2034"/>
    <dbReference type="EnsemblBacteria" id="EFI34662">
        <property type="protein sequence ID" value="EFI34662"/>
        <property type="gene ID" value="Dthio_PD2034"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="116"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="575" mass="62358" checksum="DA21E3E1CDC541AE" modified="2010-08-10" version="1">MIWVLAVFFPLLLAGLCLISKIQDKYWGRLAVLGPLPALGLAVFGSDTAPLEMPSFLLGMHLGFGEYGRYFLLLMAMVWTGAGFFSACSMHNDPDRRSYTILFLLAMCGTLGLAVAKDVVTFYAFFSLMTFTAYSLVIHNDTPSAWKAGHVYMVTAVLGEGMLTAGLMISVHVADSVMFMDISRAAAGLSPAHPMFFLLFAGFGIKAGILGLHYWLPLAHPAAPTPASAVLSGAMIKAGLLGWLYFFPVESASMPSWGAFFMCLGLLGAFFGVLAGLLEKDPKTVLAYSSISQMGLMAFLLGLALFDAALAKTALPGILMFVMHHGLAKAALFIGVGATKYARGQGAGTFLLLAALALPALALAGAPLTSGIQVKYLMKDLASMGPMYSVTGLLLPLSSLGTTLLMAHFLYRIFQAMKPADKAYPRDQALVWLVMVAASTGLPFVSVHTFEMLPAAWQADTGFIWGGLWPVMLGVLIYPAIKFWVPLQAALHSWPDTVELTERIWRLSYARWRSSPLCDPTCGQINFVYMLDRYIYGRKSMETPCSIEFRLRQWPVAGFLFVVLTLLLAGLGMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPM4</accession>
    <name>D6SPM4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870020.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34700">
        <property type="protein sequence ID" value="EFI34700"/>
        <property type="gene ID" value="Dthio_PD2072"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503494N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2084750at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="678" mass="77027" checksum="764BDDD0A9063DEC" modified="2010-08-10" version="1">MSTIMEYGLWIERTRVGLSSPRSAPLKEVDKALNAYHMNPSQDKLDKLKKALDDWKTFKKDWKNSKRNKEQVVERLTEQIEKAVSNKPSSPTKEEQEIHSLFEARWRDAAQIIFGKAELRFKSKSNLEKLQTAYGLKKDLQEVHKGTKHIQGYRENTSQSNNSSLISQESRHISRESLISEDIPLSEEARKVSAVMGKHAQQLNGIEIHALNTIAPLFEGVTDEIAKAIGEHIFTNLTWELLTGLTPFVGHVVSAGKMINGAVSTAIEANRSYSAVKHISAFAPGDPTEAAKAINIVLDRIVKREIEKAAIHTGEFTARNAAFFDAGVASGPVIGGACALARLMHKVSYIVRDYNEMRLTNESIRDQKFDTARLFDENPLLGCFFVKHAETSTLVNVLVSEYGTTGAKYEIEFLWRNHIDPMKVQATKILEESRLELLNYNKGKPLTEKDMLNRDIRKGVNLKKVKTRASQGFSHEARHMSAIGNFKKSRLKQTMTRETDPLKRQREVHAALKAVDNRILQATYFNSTVLSRESMPTGLKDLKMTNQFINMEAWKKFSYGSFFGRRTPPTVAVDMALEEYRQHTMGNMQKFGSVATASSRADIQRRLEIIQQRLFYLGNIQDKIERWLVVKDEKSSTTRRPYMMRLQQALLLEQNALNDLNAKYSNLQISVIETDLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPT2</accession>
    <name>D6SPT2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870076.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2134"/>
    <dbReference type="EnsemblBacteria" id="EFI34758">
        <property type="protein sequence ID" value="EFI34758"/>
        <property type="gene ID" value="Dthio_PD2134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="440" mass="51955" checksum="62AFE192FEADD3DA" modified="2010-08-10" version="1">MLIFAAQSMDHIVQRLSERGHGMQIRELSSYLAEINQYLPRDWRIKASKNSFFVRIQKDLPFNLVGKSYICSNSIDVIHFILTAFKIEFDDLKNIPKGVEIPSVCRPNLYYFQKPFPYSGHLSPLWARQAEKYAPEDIFEYHLVKPLTSKGVVPGISMWLQFHTLNGTITRVPEPPDYTHHKSYWMLLSESDLDLSQKKRLKRYKEELQKIEIDYTYQAPDKEGRLEYKYLTEEPFDSERLQDFDLYNYVGRNSLQIYDTYLDTKEYDLHSKNISIRLRQIKFKKKDYFFIDMKRGYIQKKKKYKRAKESWSISPVRAEKILESNSFSYPVSTVLSFLMEDHSKLKPIIKIYTDRNIFLLQNKRNMSRTEIRSDFVKAAANAEDSFDECLRELEIQGISDTSENTGTLARYLEDSLDLRPSEITKLDWALGLNQVRHSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPT6</accession>
    <name>D6SPT6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2138"/>
    <dbReference type="EnsemblBacteria" id="EFI34762">
        <property type="protein sequence ID" value="EFI34762"/>
        <property type="gene ID" value="Dthio_PD2138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="395" mass="43229" checksum="B0B3E39C504E0316" modified="2010-08-10" version="1">MADINILKVNLFPLSDVHCGFGLQQGSVLAGLNYIPGRVLRGALAGWSIRNGRIPSNKEPLFKKLFQGSDFSDSGVSFPSCRLGDRFDLPASVFRVGKTGAQDPMHKLLAGKDDESVETDFTLADTGQPIDFLRSDKMPCEVHSQLSAAGGAVKDLQTGTELSEQAPSVLDMRNRHDPQSGRVGEDGLFAEEMIPYMGADSGFSGLLICTEEALRIFEPLASRCDPMNPDPLHVIFMGRRRSPVCISAERADHILDEVLNSFDLGAQNISISFHSEYLPSESEIFPLQDSHLQKDLDLPELEIKNKFCVRGMQHGFNVVKDEHGFDSPDTQKETTGMEARPCFSPGTCVFIDTKNKIGPEDKKRLAVLSLTGAGKDTVNGSGRFFINANIHGIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPU5</accession>
    <name>D6SPU5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870087.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2147"/>
    <dbReference type="EnsemblBacteria" id="EFI34771">
        <property type="protein sequence ID" value="EFI34771"/>
        <property type="gene ID" value="Dthio_PD2147"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="995288at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="545" mass="62908" checksum="FBC9ACF86F8E745B" modified="2010-08-10" version="1">MTSSELQTVNDRKVDISLLMKRLQELILSGKDEERGRSILHKKYIWSSLSLDRSLQWARLAQAAGENELSLEILEWLNSKYPENREAWREHYQLLQFLSRDQQAARVRARALSMVPQMAGEMNQAAVVDDQGNEPVSVSDDPFWEHHRQQKLLEIYLKLFQGREDCFARQWSDKKADKQGYVPVRRPLEIEDVREHIAGRKTYGIYLLNQSSQVSTAVVDMDLDKNLLETKGLAASKKDLLRRERDYLLERIPEESRRLGLECLTEFSGRKGYHFWYFFSPPVDAGLARGALQKITKKLGRDISCFKLEVFPKQDRLSGKGFGNLVKLPLGIHRHSGKKSYFLSSKGTNVWDNMGILEKVKTNSFEETGQSSEQQESSSISVHPRYEQWASKYPELAMFIDKCPPLGQIILNCRRHKELGMREEKIIFATLGFLKRSKTLVHALFQELPDYNQHLVDYRLSRVRGTPLGCKKIHALMSMNIDYCAFEYTDGYLHPLLHCPQWTASAVPKSEKVENLQQALEQLQNSLDTVKRFLPDSSRVPEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPX2</accession>
    <name>D6SPX2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870114.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2179"/>
    <dbReference type="EnsemblBacteria" id="EFI34798">
        <property type="protein sequence ID" value="EFI34798"/>
        <property type="gene ID" value="Dthio_PD2179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088017" evidence="1">
        <location>
            <begin position="21"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="434" mass="47636" checksum="D3B70F89C1745CB4" modified="2010-08-10" version="1">MKTFKLFIVLMLCIVSISIAVSGWGDAPGARDDQNIEDITTVKEAIESGIPLEEFDDLNFNSEEEYFHMIEHGLTGSPSEDTEITLADGRTAILKEGGVSIGSEKVNVRPDPPGIVLEDGTGISGEFDISDLVDGNIPAANELNFESSEGDSSSGQGIEGFSMDGPDYTIDYADYWETESHKIVEGHGIQKKGGNIYVDEGHAIDSDDEFVSYANSYESSGDEFSIGEAKAVLLDGTLFTDIKDSYFKTKDGAITEASVTSSTDDNSFTLDGITVEMDENDTFNAKLDEETGKFDLSLDSEQGKIEATYPNVGCVEVYPGSRFEYVGSDFDDFAMFVPIFGGVYELCIRTLENEDFDSDCNNCGVVDYKNKTAEFNGIYQYEKPSAFENGLFRNMIDASGNYSMEADNHKFNNTYIFRRSHGDAALEHKAPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ25</accession>
    <name>D6SQ25_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="12" type="ORF">Dthio_PD2242</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870165.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2242"/>
    <dbReference type="EnsemblBacteria" id="EFI34851">
        <property type="protein sequence ID" value="EFI34851"/>
        <property type="gene ID" value="Dthio_PD2242"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1872106at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="153" mass="17038" checksum="A7C917AA330DD954" modified="2010-08-10" version="1">MPGEKYTVLMVNGPNLGYIGRRDPGTYGTRGMDAVQTILEKDRPGLLDRIELNYFQANGEGEIIDRLEKAWKDNVQGLVINPGAYTHTSLALGDCLAWINIPHVEVHLSNIWSREEIRRQNLTAAHSLGVIAGFGIMSYVLGLEALVWYLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQC5</accession>
    <name>D6SQC5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha</fullName>
            <ecNumber evidence="8">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Dthio_PD2343</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the AccA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870265.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2343"/>
    <dbReference type="EnsemblBacteria" id="EFI34951">
        <property type="protein sequence ID" value="EFI34951"/>
        <property type="gene ID" value="Dthio_PD2343"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0777">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504557at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="20" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="54"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="486"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFI34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="746" mass="84871" checksum="E3A5AA421FC4A8B9" modified="2010-08-10" version="1">MTDIEKQIQDLRERLQYIEDIFGNRENTNITLLRSKLQDFIHNLPSLGPGQIKRQLTSLSDLFSFLENKLEKELTPMDRVRIVRHPQRVCLKDILENVYDNYTEIGGQGEYSIDPSMIIARAYITRNVGKKTYKQPVMVIGQEKGHGEEFRNGGSVKPWGNAKALEYMKVAERENIPIHTYIFTPGSYPIEDYPGAAQQIARNIYAMAGIRVPVIAVLSEGGSGGAEAIGLTDTRIMLSHGYYSVISPEGAAAIEGRSSSTRKASAQLVESCARQLRITARDNLEMGYVDRILQEPPLGARPDHFDFFRKLRREVILATDEIVLSIRGVKLFRAIALRKLNNPNIYVRWSISSKSKERLIWRRYQKYRGLCSWAYQDRSTNFQKCKSAVLETGWSVYSFLRYEFFGRHQRAITHLAEDVQGEVHALMDRVTHRFSSLFKKLPWVRKEREDACQLTTLSTWEAGMSWNEHCRYVSPQANQDKTLTCPNSEKHNCLDLWAPDLFGDFAGVCSHCGHHFPMEYEWYLFNVFDSRSIREFNAPIEASNPLEFDGLTHKLDKAKKQTGHKSACMTFEAKIKGIQVAVAMLLARFRGGSVGAAEGEKFIRAAEQARRKHMPFLAYVHGTAGIRIQEGTNGLLQMPRCTLAVRRYLESGGLYLVVYDTNSYAGPVASFLGCSPYQFAIRSANIGFAGPGVIRETTGMDIPPNYHKSFQALSRGHIQGIWDRREIRNNLHHALMTMGGEFLYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQF6</accession>
    <name>D6SQF6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="10">1.2.7.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870296.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2374"/>
    <dbReference type="EnsemblBacteria" id="EFI34982">
        <property type="protein sequence ID" value="EFI34982"/>
        <property type="gene ID" value="Dthio_PD2374"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332680at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="579" mass="61486" checksum="C79D6DA796395CC0" modified="2010-08-10" version="1">MDKILRIDVGAPGGPKATEEPIGDYAGMGGRGMTTSVVYKEVPPDCHPLGPENKLVIAPGLMSGSAASSSGRMSVGCKSPLTGTIKESNAGGTGSQALARLGYAAVILEGERQGEDMYKVVINDQGVSLEKANDLKMLANYDLIDKLKPVHGEKVSVISIGTAGEMRMSNSSIAVTDPEFRPTRHCGRGGVGAVMGSKGIKCIVVDASGAKTRKPVRPDEFKESNKKFVEGLKAHAVTGQGLPTYGTNVLTNILNEAGGYPTYNFREGRYKHAQNLSGELQAENMKNREGGQPTHGCHRGCIIQCSGIYTDKDGNYMSKQPEYETVWSHGGNCGIDDLDAIARLDYLDDHYGLDTIEMGVTIGVAMEAGVIEFGDAEGAINLVHEVGKGTPLGRILGAGAATTARCYGMEHAPVVKGQALPAYDPRSVKGIGVTYATTTQGADHTAGYAVTANILKVGGDVDPLQTGGQAELSRNLQIATAALDSTGFCLFVAFAILDQGETFEAMVQTINHMYGLDMTGDDVVALGQKILKMEKEFNEKAGFGPAHDRLPRYFSREPLAPHNVVFDVPDKELDSVYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQK0</accession>
    <name>D6SQK0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit</fullName>
            <ecNumber evidence="5">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870340.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2420"/>
    <dbReference type="EnsemblBacteria" id="EFI35026">
        <property type="protein sequence ID" value="EFI35026"/>
        <property type="gene ID" value="Dthio_PD2420"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="52"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="4">
        <location>
            <begin position="198"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="282" mass="30745" checksum="748A392530E21410" modified="2010-08-10" version="1">MVSMEDFGSFETAWCPGCGNHSILKCVKEALVQMELEPHQCIFVSGIGQAAKSPHYLRTNVYNGLHGRALPAATGIKLANPQAVVIAQSGDGCNYGEGGNHFLAALRRNINVTLLAHDNQIYGLTKGQASPTTARGQKTKAQPAGNPSEAFNPVGVAVAMQAGMVARGFAGMQDHLTEMIVKAVQHPGFSLVDILQPCVSFNKVNTFAWYKERCYIPEDHDPQNWEQAMALSRQWDEGIPLGVIYQSHKPTFEESLPHPTGEPLFNNRPSIQKLNEVMSSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQL1</accession>
    <name>D6SQL1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870351.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35037">
        <property type="protein sequence ID" value="EFI35037"/>
        <property type="gene ID" value="Dthio_PD2431"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2013836at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="63" mass="7268" checksum="A85AF4A23E4AF7C5" modified="2010-08-10" version="1">MDDWVEVARFDSMSDAVHKEKARIENMALDVGLMPEKVVQVEDKGKIIISVHPEFYDYYGHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQN3</accession>
    <name>D6SQN3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="16" type="ORF">Dthio_PD2453</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870373.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2453"/>
    <dbReference type="EnsemblBacteria" id="EFI35059">
        <property type="protein sequence ID" value="EFI35059"/>
        <property type="gene ID" value="Dthio_PD2453"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="383"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="485" mass="52200" checksum="244BA99271FBA269" modified="2010-08-10" version="1">MEKIWGQGLTFDDVLLVPDYSEVLPEETSLKTRLTPKIELNIPLLSAAMDTVTEAEMAISMARSGGVGVVHKNMGIEEQSQEVERVKKSESGMIVDPVTVHPGDDVETVLRLMSEYRISGLPVEEDGRLVGIVTNRDVRFVSDLRTRVDQVMTSGDLVTVPVGTTLLEAKDILQKNKIEKLLVVEKGGGLKGLITIKDIEKIKKYPNACKDEMGRLRVGAAVGTGEDKMARVEALIKAGSDFIVLDSAHGHSRNIIQGIRDIKASYPDCQLIAGNVATYEGAKSLVDAGVDAVKVGIGPGSICTTRVVAGVGVPQVTAIMECTRACREKGCCVIADGGVKFSGDVIKALVAGADTVMMGSMLAGTQESPGETILYQGRTYKIYRGMGSIDAMREGSSDRYFQEKSSKLVPEGIVGRVPFKGPAGDTVYQLIGGVQSGMGYLGCATVQELHEKGRFLTMTPAGYRESHVHDVIITKEAPNYRIENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQP4</accession>
    <name>D6SQP4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplM</name>
        <name evidence="5" type="ORF">Dthio_PD2464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870384.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2464"/>
    <dbReference type="EnsemblBacteria" id="EFI35070">
        <property type="protein sequence ID" value="EFI35070"/>
        <property type="gene ID" value="Dthio_PD2464"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="142" mass="16341" checksum="10E2EEDCC5A215B4" modified="2010-08-10" version="1">MKTYSPKPEDIKRDWYVVDAQDKILGRLATRIATKLRGKDKPEFAPHMDMGDFVVVVNAQQIKVTGDKLEQKKYYYHTGYPGGIKENSLDRMLQKKPEEVIRKAVGRMLPKNKLGRKLLKKLKVYSGPEHPHAAQQPKVIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQZ0</accession>
    <name>D6SQZ0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerophosphatase A</fullName>
            <ecNumber evidence="1">3.1.3.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphatidylglycerolphosphate phosphatase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870480.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2564"/>
    <dbReference type="EnsemblBacteria" id="EFI35166">
        <property type="protein sequence ID" value="EFI35166"/>
        <property type="gene ID" value="Dthio_PD2564"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1969080at2"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06971">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026037">
        <property type="entry name" value="PgpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007686">
        <property type="entry name" value="YutG/PgpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36305">
        <property type="entry name" value="PTHR36305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04608">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006162">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0595">Phospholipid degradation</keyword>
    <keyword evidence="1" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PgpA" evidence="3">
        <location>
            <begin position="15"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="18005" checksum="4C567BBE515F675B" modified="2010-08-10" version="1">MNAGNTVLQTLGRHLATVGPVGYIPIAPGTWGSLAAVIAAPWLFLPFSLTVQILILAALFLLGSWACSAAETHFGRKDPGQAVIDEVLGQWVTFLFLASSGIFLLAAGFFLFRLFDILKPWPVRSSEKWFPGGYSVMVDDLLAGIYALAALTILERLILANLFPSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR06</accession>
    <name>D6SR06_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase (AAA+ superfamily)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870496.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2581"/>
    <dbReference type="EnsemblBacteria" id="EFI35182">
        <property type="protein sequence ID" value="EFI35182"/>
        <property type="gene ID" value="Dthio_PD2581"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="174"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="44607" checksum="399CB3918CF60B14" modified="2010-08-10" version="1">MQKRTIQPALDSLAAKYPVVTVTGPRQSGKTTLCRMAYPDRKYVNLEAPDERQFAIDDPRGFLAECSSGAVLDEIQRVPDLVSYLQPVIDEDPAPGRFILTGSQQFNVREALSQSLAGRTGLLTLMPFDWQEIQSFQSVSQTDRLILHGFYPRLHHMGINPTQAMADYFETYVQRDVRQIVQIRNAGAFERFVRLCAGRIGQLLNLNSLGNDAGVSHTTAREWISILEASYIIFQLPPWHASISKRLVKTPKLYFWDVGLASYLLGLQEEKQVSRDPLRGSLFENMVVAELFKQCYHQGKRPRFYFCRDSTGNEVDVFIERGHDLALIEIKAGQTVNRAYFQGLDRFKNVLGERIKGGLVVYGGGKAQRRSAWEVWPIQDIGGLGSRVHDFFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR32</accession>
    <name>D6SR32_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870514.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0471"/>
    <dbReference type="EnsemblBacteria" id="EFI33148">
        <property type="protein sequence ID" value="EFI33148"/>
        <property type="gene ID" value="Dthio_PD0471"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="35503" checksum="63F0B8B02D157D8B" modified="2010-08-10" version="1">MPRIARFIRSDQATVYHVISRTALSGLPIKDTDKDYLLGLIKRLSRLYFVDVLGFAVMGNHFHLVARMHPEDEISNSDIIKRWQKYYGDEAQVPTDRMVEVKKRLCSLGAYVKDIKQNFTRYYNKKHRRQGFFWGGRFKSMIVQEGSTLVNLLAYVDLNPIRAGIVKKPEDYRWSSLGYHTQTGNKDGLLDIDFGLKEWNELDPKEIVRKYRQFVYETGAVDAGKGKTIDQKVVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDTRKFTPVGGVEGLYSMKRLGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR79</accession>
    <name>D6SR79_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliW</name>
        <name evidence="4" type="ORF">Dthio_PD0521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870553.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0521"/>
    <dbReference type="EnsemblBacteria" id="EFI33195">
        <property type="protein sequence ID" value="EFI33195"/>
        <property type="gene ID" value="Dthio_PD0521"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1767625at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="159" mass="17782" checksum="ED01A2ED045C2BF7" modified="2010-08-10" version="1">MDQTEQKKVDTRLGQFILEEDKSIHFPRGLIGMERFKEFALLQIKPDSPFLLLQSLDDSRLGLLVADPFSFIREFEVRLSSVEENVLQVEDKKDLAIMVTVSIPSGNPESATLNLSGPIVINSKKKLGLQSVQAEPGTRSRVLLSELKSVPDHSDITHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR80</accession>
    <name>D6SR80_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csrA</name>
        <name evidence="3" type="ORF">Dthio_PD0522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870554.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0522"/>
    <dbReference type="EnsemblBacteria" id="EFI33196">
        <property type="protein sequence ID" value="EFI33196"/>
        <property type="gene ID" value="Dthio_PD0522"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2032250at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9170" checksum="D700C7E5905AA206" modified="2010-08-10" version="1">MLILTRRAGESIHLGEDIIISVLSMKGKQVKLGIEVPEDLPVYREEVFKKIQQENEQAILACSQDFMAAADLWTRQNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRE9</accession>
    <name>D6SRE9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870623.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0591"/>
    <dbReference type="EnsemblBacteria" id="EFI33265">
        <property type="protein sequence ID" value="EFI33265"/>
        <property type="gene ID" value="Dthio_PD0591"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="202"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="368" mass="43035" checksum="650C82A3B0FB1F1A" modified="2010-08-10" version="1">MSSTKDRSPALQIDLSSLQDYLQKQFGTGARLIEAGEMGSAGKQGMKEFGYGKPLHIRFELDGEEKQAVLSTMRGDSFGHQFYWDRAAILMFQYETGESMEKHVSSLGFGYVDKKDNLVPVVEPREFFILHEMAEGYDYFLDLERIKKKGLKQSDLELTKEFSRWMARLHSRRLDDADLYLRRIRNLIGASECIFGLVDSYPHPYDLFPPERFEELECRLISWRWKLGSFTHRLAAVHGDFHPWNVLVQPDGDFRVLDRSRGEWGEPADDITTMTSNYLLYSLYSGPSLKGDFEKLYRTMWDTYLEETGDWEILHTAAPFYVFRALVIASPKWYPGHSREVRMSLFRFMENVLQDEEFDYENINKYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRG1</accession>
    <name>D6SRG1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870635.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0603"/>
    <dbReference type="EnsemblBacteria" id="EFI33277">
        <property type="protein sequence ID" value="EFI33277"/>
        <property type="gene ID" value="Dthio_PD0603"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923142at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="220" mass="24304" checksum="993E39B0EECB9F42" modified="2010-08-10" version="1">MNNQPISTEAAYAFGTAKLSFDKIFLNFIKRLETIGSAWPFFARAYYRLFYKKMLQSEIKASGIKPGMQVMHVGCGPLPMTAMGLAGFGARVTAVDQDAGTLGWAGRALEKSGTKDRVSLVAGCGTNLDFTGFDAVWLSLHVRPMGPVLNRVMEHVSPGSRIVFRDPRDYLCSYYPGADNFSDKCGCKSLRVKQMLGKKSVVLIKEMPAEKNTQELEKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRI0</accession>
    <name>D6SRI0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheC, inhibitor of MCP methylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870654.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0622"/>
    <dbReference type="EnsemblBacteria" id="EFI33296">
        <property type="protein sequence ID" value="EFI33296"/>
        <property type="gene ID" value="Dthio_PD0622"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="203" mass="21982" checksum="349F740D930ECCFA" modified="2010-08-10" version="1">MLNDLHRDALTEIINIGVGQAGNALNSMLAMHVELSVPEIKVLEPEDVQQELAPLDKSSLATVILRFSGPVPGKAALLFPPESALNLVTLLVQEEPGDTDLDSIRSEALTEIGNIVLNSVLGNFANILSMDLEYSLPDFMFETSVHDLLQQEGGEGHSIILAKAHFKVREHSIAGDILLLFGINSMTELSSMLDMLVKKQAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRI8</accession>
    <name>D6SRI8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870662.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0630"/>
    <dbReference type="EnsemblBacteria" id="EFI33304">
        <property type="protein sequence ID" value="EFI33304"/>
        <property type="gene ID" value="Dthio_PD0630"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="457" mass="51194" checksum="35101355A2B1CC9D" modified="2010-08-10" version="1">MNSHILVIDDEKNYLLILETILEEEGYTVTALNDPQMALDYLDESEVDVVITDMKMPGISGQDILEHIQKHHAQIPVLIMTAYGSIDGAVEAMRCGAFDYISKPFSNDELMLSVRKAALLSKSEQEKRLMTQTLAEQYGPHKLVGNSRSIREVLQMVSKVAPSRSTVLITGESGTGKELIARAIHYSSPRREGPFISINCMSLSPGVLESELFGHEKGSFTGATAMKKGRFELADGGTLFLDEVGELSQDLQVKLLRVLQEKAFERVGGSRTIHADIRLVAATNKDLKQAVEKGEFREDLYYRLNVVGINLPPLRERREDIPVLVAHFMQKFSSENQQELKKFAPEALEYLTAYEWPGNVRQLENVVERCMVLASREEIGVEDLPSEIKDEEAQFKSAVDLLPVELELSGTLEKIEAALIRRALVKSGFVQVKAAELLNISKSLLQYKLKKYNIQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRM1</accession>
    <name>D6SRM1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ORF">Dthio_PD0665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870695.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0665"/>
    <dbReference type="EnsemblBacteria" id="EFI33337">
        <property type="protein sequence ID" value="EFI33337"/>
        <property type="gene ID" value="Dthio_PD0665"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="117" mass="13659" checksum="DF2D62A8055F1D25" modified="2010-08-10" version="1">MRVKRGKTANKRHKKYLKMAKGYRGSRSRLFYTAKETVERALCYAYRDRRQKKRDFRKLWIIRINAAAREHGMSYSRFMSGLSKAGVELNRKVLADMAVHEKAAFARLAEMARTGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRM8</accession>
    <name>D6SRM8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0672"/>
    <dbReference type="EnsemblBacteria" id="EFI33344">
        <property type="protein sequence ID" value="EFI33344"/>
        <property type="gene ID" value="Dthio_PD0672"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="297" mass="32109" checksum="1EC80EF3EC998ACF" modified="2010-08-10" version="1">MYICIDLGGSNIRGTWMDRDGRCGEVLNVPRPRELAGTKKALAGLIQNVMQKSPGAVNNIGIASAGPLNLEQGIYFTPTNMPELKGFDLAGFVSGIFGIRPVLENDAQAAALGEIFNGCLAGEKDALVFTLGTGLGSGVIMDRRVWRGRLDAGPELGHVYMGPNRGKRCGCGQTGCAETWLNAAALKELAMQNGLSLASLKDLDIYLEKKDEKALVTMQQYGRRLGLFLSQMVSIFGIKNIGLSGGLSRLGPCFSEVVPQSINFRLKTRPWLIPDRIELSPDPQMSALWGMGYLMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS28</accession>
    <name>D6SS28_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prmA</name>
        <name evidence="3" type="ORF">Dthio_PD0828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870846.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0828"/>
    <dbReference type="EnsemblBacteria" id="EFI33494">
        <property type="protein sequence ID" value="EFI33494"/>
        <property type="gene ID" value="Dthio_PD0828"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="295" mass="33041" checksum="3CCBA0FC185BBA6D" modified="2010-08-10" version="1">MFKLKIKAGPDEKEALESLLYEHISWGWEEEELPGQALVFDIYFHQEDAGHRFKEVSRSMCPHIEIMEETVPVQDWNNAWKDFFTPIEVDQRFVVLPDWLQHEKQAAVPIIITPKMAFGTGHHATTYLCLRAVSRLWDLGYLKSGQNFLDLGTGSGILGIACSRLGMSGLGVDIDPVAVENAQENTRINRVGEMFEVREGGLSSLRPDQKFNLILGNILSSTLKQLAPDIIKHLDDSAILVLSGILTDQASSVEERYEALGLGRPARLNMQEWSALVWAGGKDSREQLNLVDALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS74</accession>
    <name>D6SS74_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="5 9">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuA</name>
        <name evidence="11" type="ORF">Dthio_PD0874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="5 9"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0874"/>
    <dbReference type="EnsemblBacteria" id="EFI33540">
        <property type="protein sequence ID" value="EFI33540"/>
        <property type="gene ID" value="Dthio_PD0874"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="514" mass="55733" checksum="8A3D2A7275BAC9D6" modified="2010-08-10" version="1">MSDRIYIFDTTLRDGEQSPGATMNAGEKIRLARQLERLGVDVIEAGFPAASTGDQEAVAEIAAAVKDCQVAGLCRAVKEDMDKAWEAVKHAAQPRLHTFLATSDIHMKYKLDKTRDQVLEIAHEAVTYAGSLCPSVEFSAEDASRSDPAFLVQVVQTAIDAGAKVINIPDTVGYAQPQEYAELIDYLLTNVKESERAIFSVHCHNDLGLGVANTLAACKAGARQAEVTLSGIGERAGNAALEELVMALNVRKGFYNLETGINTEQIYPSCRLLSMIIGQPIPPYKPIIGGNAFAHESGIHQAGMLKNRETYEIMTPASIGKAGSDIVIGKHSGRHALNQKLEELGYRLTRDQLTQVSEVVKSLADKKKKLYMEDVEAIVLEEVYRIPDKFKLIYLSSISGNMAIPTAAMKMEVLGEEKQLSDFGVGAIDAVFNTIDRLVQRNPTLLRYSVSAITGGADAQGEVTVKLEENSVTSVGRAADPDVIVASAKAYINALNRLAKKETDPKAEQSRNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS88</accession>
    <name>D6SS88_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome d ubiquinol oxidase, subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870904.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0888"/>
    <dbReference type="EnsemblBacteria" id="EFI33554">
        <property type="protein sequence ID" value="EFI33554"/>
        <property type="gene ID" value="Dthio_PD0888"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="761975at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="341" mass="37911" checksum="8E2C18B2DEB41D6A" modified="2010-08-10" version="1">MLETTWFLLWGILWAGYFALDGYDFGLGINMPLLAESETDKRVMYNAAGPFWDGNQVWLITAGGVTFAAFPATYAVLFSSLYTPLLLLLFALIFRGVSFEFRRKVDSDSWRRFWDGCNVLGSLIPALLFGVAFANIFMGIPLNAQQINEGNLLTLLNPYGLAGGILFVLLFSMHGSLWLAVKSMGDMERKAVNLANRVWGAVLVMVVAFLALTVMYTNLFDNYAANPLLLIILLIPVAGLVLVKMFLHQRVYWKAWASSAATIIGVTMFGVIGMYPKLLPSSIDPDFSMTIANSASSTLTLQIMLGVALVFCPLVIAYQTWVHLKFSHKITDEDLEYEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSF0</accession>
    <name>D6SSF0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870966.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0951"/>
    <dbReference type="EnsemblBacteria" id="EFI33616">
        <property type="protein sequence ID" value="EFI33616"/>
        <property type="gene ID" value="Dthio_PD0951"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1947018at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015221">
        <property type="term" value="F:lipopolysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010664">
        <property type="entry name" value="LipoPS_assembly_LptC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026265">
        <property type="entry name" value="LptC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06835">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04409">
        <property type="entry name" value="LptC_YrbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="180" mass="20594" checksum="08B79099C8FF20DA" modified="2010-08-10" version="1">MLKKAFPIILTVMLMFFLLSIFWRETPGPRQVDFDQDLEVDLNIRDLTLVQSGRDKKIWELDAKQAGFMRKENIYLLQEPVMTYFGEKNGEPVEIRAARGRIDQDSGTLYMWPDVKARSGGLYTTSEKATYKEGEGHVLLEDNVSFTGRGMRVDTPRALIMLEEDKIVATQGVRTSIRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSH3</accession>
    <name>D6SSH3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative circadian clock protein, KaiC</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870988.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0974"/>
    <dbReference type="EnsemblBacteria" id="EFI33639">
        <property type="protein sequence ID" value="EFI33639"/>
        <property type="gene ID" value="Dthio_PD0974"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271085at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030665">
        <property type="entry name" value="KaiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039117">
        <property type="entry name" value="KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KaiC" evidence="3">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="KaiC" evidence="3">
        <location>
            <begin position="249"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="562" mass="63181" checksum="17F40B82868460A4" modified="2010-08-10" version="1">MTQHNNYLSKSPTGIQGLDEVLDGGLPSGRSTLVCGSAGCGKTLLGMEFLIHGAQQFQEPGVFVAFEETEEDLARNVASLGYDLTSLVQERKMLVEYVHVAREEIQETGEFSLEGLFIRLEHAINTTGARRVVLDTLETLFSALPNHFILRAELRRLVRWFKDRGVTVILTGEQGEGTMTRHGLEEYVSDCVIMLDHRVINEVCTRRLRVVKYRGSTHGTNEYPFLIDGKGFSVLPVTSLNLQHRVSTERVNTGITGLDNMLDNQGYYRGSTVLISGTAGTGKSSIAAHFADAAGRRGEKTLYFTYEESPHQVLRNMSSIGIHLEPWINQDVLRFEAARPSVYGIEMHLARIMQCVKEFQPSVVIVDPINSLLGESNQPSVKAMLMRLADFLKGQGITALFTSLTIGGRHQESTDTEISSLIDTWLLLRDIEISAERNRGIYILKSRGMNHSKQIREFILTDHGVELVDVYAGTEGILTGTARLAREARDRAEKNKRSRRIQQKKHDIENRRKALEAKISAMQAEFESQEAEINMLIQEEQNQEQLMEQDMDEITKSRQGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSI3</accession>
    <name>D6SSI3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH ubiquinone oxidoreductase 20 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD0985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870998.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0985"/>
    <dbReference type="EnsemblBacteria" id="EFI33649">
        <property type="protein sequence ID" value="EFI33649"/>
        <property type="gene ID" value="Dthio_PD0985"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="798037at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009375">
        <property type="term" value="C:ferredoxin hydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027394">
        <property type="entry name" value="Cytochrome-c3_hydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037148">
        <property type="entry name" value="NiFe-Hase_small_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001821">
        <property type="entry name" value="NiFe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30013">
        <property type="entry name" value="PTHR30013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14720">
        <property type="entry name" value="NiFe_hyd_SSU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000310">
        <property type="entry name" value="NiFe_hyd_ssu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0574">Periplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="11">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="NiFe_hyd_SSU_C" evidence="12">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="311" mass="33578" checksum="97BCA6CCD117F067" modified="2010-08-10" version="1">MKTAFWMQAGGCGGDSMSFLSQSFACTSNLFQALDIDLLWHPSFSCIAMQDQKRLLEDLAAGKIPLDIFILEGSVICGPSGTGLFDTHMGRPRKDLVQQLTMQADTVIAAGTCASFGGFGADGEAGSTGLQFHKTRPGGLLGPDFRSGSGQPVINLAGCPCHHDVMAGALAAAARGTAMDLDEYHRPREWYGTMIHQGCTRNEYHEYRVEESDFGELGCLFFHMGCAGPLVPGPCNKLLWNQQSSKPRAGVPCFGCTDPEFPGKNPFFYTQNIEGIPLSLPNGVNRAHYMVYKSMAAAAAPLRLKKRTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSN1</accession>
    <name>D6SSN1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate ABC transporter phosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871046.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1036"/>
    <dbReference type="EnsemblBacteria" id="EFI33697">
        <property type="protein sequence ID" value="EFI33697"/>
        <property type="gene ID" value="Dthio_PD1036"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088182" evidence="1">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="24"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="31483" checksum="5CDC2252D4A23686" modified="2010-08-10" version="1">MQFKVMIMGFFALGFLFCSAAPSDSAEQNVLNIAGATTIQPVLEVLADDYQHKSGQTVQIQGGGSSRGIEHVLQGHGPLGAVSRALTPEEKKELEYVTIGKDALVFIVNKRNPVESIDRDTAVRLFRGETKNWNELTNWERSVVLVTKEMGRSTLDLFEKYTGIHHPDNPEDGENGRVDESAYEIASNLDGVTLVAGMPGGVGYMSLGASEYLRDKGMPVKILELEGYSMDRDSIVAGDYPISRELNLVYKEENKDLVQGFLDFCLGRTGQEAVRDLGYIPVKESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST22</accession>
    <name>D6ST22_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SirA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871187.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1177"/>
    <dbReference type="EnsemblBacteria" id="EFI33838">
        <property type="protein sequence ID" value="EFI33838"/>
        <property type="gene ID" value="Dthio_PD1177"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="8965" checksum="53EA1EC519AB8880" modified="2010-08-10" version="1">MKLPPRIIADKVVDARGLSCPLPLLKTKKALDSLKSGQTVKIICTDPGSKDHIPDLGLRNGSSFLGMEHSDEDTLSYFIQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST53</accession>
    <name>D6ST53_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871218.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1208"/>
    <dbReference type="EnsemblBacteria" id="EFI33869">
        <property type="protein sequence ID" value="EFI33869"/>
        <property type="gene ID" value="Dthio_PD1208"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="149" mass="17346" checksum="4C11E43A28DA59C9" modified="2010-08-10" version="1">MQLIYLDMCCFNRPYDDQNQSRIRLETEAKLIIQKKVKQRECGLLWSSTLDFECQKNPFAEHRLAITRWRYLAERIIFATPEVVATAHRFASFGLSNYDALHVASAIEGKADFFITTDDRIHKKISGNREIQVAFPNNALAALENWYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6STE1</accession>
    <name>D6STE1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD1296</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871306.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1296"/>
    <dbReference type="EnsemblBacteria" id="EFI33957">
        <property type="protein sequence ID" value="EFI33957"/>
        <property type="gene ID" value="Dthio_PD1296"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="179" mass="20115" checksum="378EFF46376BAA0B" modified="2010-08-10" version="1">MFNLPNSLTFARIATVPIIVILLYFPSRTTAAAAMLIFIIASLTDLFDGLLARRYNQVTKMGKFLDPLADKILITAVLIMLVHNSWLHAWIAIVIITREITVTGLRAIAAEQSIVISADRYGKLKTIFQVVALCPLMLHYPWWGFDPTLLGQILIHIAMILAVVSGINYLRVFYVQAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6STG3</accession>
    <name>D6STG3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD1318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871328.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1318"/>
    <dbReference type="EnsemblBacteria" id="EFI33979">
        <property type="protein sequence ID" value="EFI33979"/>
        <property type="gene ID" value="Dthio_PD1318"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="430" mass="49572" checksum="D59D4F77DCF05D5B" modified="2010-08-10" version="1">MIERYTRKEMGELWTQEKRFRAWLEVELAICEAWHELGAIPAQDMENIRARADFDLDRILEIEERTRHDVIAFLTAVEEKVGPSARYIHLGCTSSDIVDTANALSLYRAGEIIAKALDGLLQSLDRISHEYKGRLMMGRTHGIHAEPISFGQKMAGFYAEMRRHEARWQRALEQIRVGKISGAVGTYAHLDPRLEELACRKLGLEVDPVSTQIVQRDRYAEYFTALALMAGGIERLCVELRHLQRTEVLEAEEGFSKGQKGSSAMPHKKNPISAENLTGLSRLVRSNALAAMENMALWHERDISHSSVERVIMPDSTILIHYMLTRLTNLLDKLQVNDANMEYNLDLSMGLYFSQRVLLALVEKGLERQKAYELVQEDAMYCWENKVYFPDRIRENQEILKHIPLDELDAVFDMGYYLKHEDLVFQRVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6STH3</accession>
    <name>D6STH3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetate/CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871338.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1328"/>
    <dbReference type="EnsemblBacteria" id="EFI33989">
        <property type="protein sequence ID" value="EFI33989"/>
        <property type="gene ID" value="Dthio_PD1328"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="7">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="5">
        <location>
            <begin position="96"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="6">
        <location>
            <begin position="536"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="639" mass="71922" checksum="F884AECBA6ABA2BD" modified="2010-08-10" version="1">MEDKGALDSLLQEERIFRPLPQMVIDANINPQEYSAVMKQCQENYLDYWEDAAKEMDWFKKWDKVLDDSEAPFYKWFTGAKCNIVYNALDRHINTANKNKLALIWEGEPGDTKKFTYYELYRAVNRFANALRSLGIKKGDRVVLYMPPLPETMISILAVAKIGAVHSMVFAGFSAKALRERIQDAEAKLVITADGFYRNGRPANVKNLVDKALVGGCETVDTVVVVHRAGVEVEMTEMRDIWYEDLVRQESPVSETEVMDSEDMLFLLYSSGTTGKPKGIVHTHGGYMVGVHRTLNWIFDIKPTDIFWCTADMGWITGHSYVVYGPLMAGTTTMLFEGHPLYPQADRLWQMVARYGVTIFYTAPTLIRMLMRFGSQYPKQHDLSTLRLLGSVGEPINPEAWMWYYNNIGRAECPIIDTWWQTETGSVMISPFPITLLKPGSCSKPLPGIEADVVDEEGNPVPPGKGGQLIIKKPWPSMLRTLYKDPERYKKTYWEKIPGVYLAGDVARKDEDGYFWIQGRSDDVISIAGHRVGSAEIESALVAHKAVSEAAVIGVPDKIKGEVAKAFVTLSAEYTVDDPDELIKTLKSHVRSELGPVAVIKGIEFRDTLPKTRSGKIMRRVLKAQELGEDVGDTSTLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6STJ6</accession>
    <name>D6STJ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1351"/>
    <dbReference type="EnsemblBacteria" id="EFI34012">
        <property type="protein sequence ID" value="EFI34012"/>
        <property type="gene ID" value="Dthio_PD1351"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="90"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="269" mass="31131" checksum="705BB3E900D6FA16" modified="2010-08-10" version="1">MRTMSVTENRDNYVTHPSGASWIFSRTPSLYFYPRMLGTVLRSWAKARWKGFTDHDWILRSVDIFRHLEKVDCRFIIRGKKNFIDLDEPCVFVGNHMSTLETFALAAVVCPHRQVTFVVKEGLVRYPVFKHVMISRDPVVVKRQNPRDDFKVVMQEGLDRLNRGISVVVFPQAERSRVLDLQRFNSMGVKLAKKAGVPVVPLALKTDAWGQGSIIKDFGWIRPNRPIRMDFGPAMQVQGNGRAEHQEIVDFISYRLDAWQGYARWFGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6STP3</accession>
    <name>D6STP3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871408.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1398"/>
    <dbReference type="EnsemblBacteria" id="EFI34059">
        <property type="protein sequence ID" value="EFI34059"/>
        <property type="gene ID" value="Dthio_PD1398"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1159320at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="395" mass="42276" checksum="363D3C3F6061BA20" modified="2010-08-10" version="1">MHKKFFLACLFSLALFLALQGMAFADVDVEEIIEDPHLLEEAIQSAHESGHLDKDDPEGYLGIPGAPQINLFIAFIWAIVVGWIFSTVGAFGGIAAGIGHISIYGLGAYADKFEGKSAAINTAVTDSIRVSNQFMVGFSALVSTLNYWKLGRLVIPVGIALAIGSILGSYLVPTLTAGRISFEDYISLFGIFVLALGCWMFYQTTPRGQKSKKKAKEAAQAFEETMKRKRSGEAIDTSELGVKMTSFNPKKISFAFYGVEFSFNPLFPILGGFVIAAIAAFLGVGGGFMLVPFITAVAGLPMYLAAGTSALAVLVGMITAILSYLAAGVLVHWSLIGTQLVGIFIGSMIGPRTSQYIPEKVLTRIFIVLAFYVGINYIIMGITGTQIHEFLAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6STY1</accession>
    <name>D6STY1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871496.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34147">
        <property type="protein sequence ID" value="EFI34147"/>
        <property type="gene ID" value="Dthio_PD1489"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XZ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2049035at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045397">
        <property type="entry name" value="DUF6516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20126">
        <property type="entry name" value="DUF6516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="109" mass="12246" checksum="B97550D8D9A066DB" modified="2010-08-10" version="1">MDLYGFADVIDIQEELRAGKQAVIQASVVLVDGSSLHVREYIDAAYGIKKVSYGYHYQDRHGKLVFRYDNARHKPALKSKEHKHLSDNSIVEAAAPSISELVEEVVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU28</accession>
    <name>D6SU28_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0434"/>
    <dbReference type="EnsemblBacteria" id="EFI33119">
        <property type="protein sequence ID" value="EFI33119"/>
        <property type="gene ID" value="Dthio_PD0434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="12691" checksum="4C4FBE3321ED0B16" modified="2010-08-10" version="1">MRIWLKRASHDLHQMELDYWNDLSDDEKKEWEVEEFFTLEDEFFRIRDEYMEFKKVPSRIRHADIPYRPILASLFKSIRDFEERCRLLDLFYRNYDDCASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU81</accession>
    <name>D6SU81_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871555.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0169"/>
    <dbReference type="EnsemblBacteria" id="EFI32861">
        <property type="protein sequence ID" value="EFI32861"/>
        <property type="gene ID" value="Dthio_PD0169"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="35498" checksum="9CBF01A0003B574C" modified="2010-08-10" version="1">MPRIARFIRSDQATVYHVISRTALPGLPIKDTDKDYLLGLIKRLSRLYFVDVLGFAVMGNHFHLVARMHPEDEISTSDIIKRWQKYYGDEAQVPTDRMVEVKKRLCSLGAYVKDIKQNFTRYYNKKHRRQGFFWGGRFKSMIVQEGSTLVNLLAYVDLNPIRAGIVKKPENYRWSSLGYHTQTGNKDGLLDIDFGLKEWNELDPREIVRKYRQFVYETGAVDAGKGKTIEKKIVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDERKFTPVGGVEGLYSMKRLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUC0</accession>
    <name>D6SUC0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871593.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0214"/>
    <dbReference type="EnsemblBacteria" id="EFI32900">
        <property type="protein sequence ID" value="EFI32900"/>
        <property type="gene ID" value="Dthio_PD0214"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="68"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="238" mass="26743" checksum="F209285CCA5F41E2" modified="2010-08-10" version="1">MIPLKDSIPNVYRPYMVMGLIGINALVFLYTVSLGPEGMNRIFHLYGLVPARFTQPEWAAWMGYPEAGFYTAITYMFLHGGFWHFLINSWMLWIFAVNIEDVMGSLRFLLFYLVCGVAALGTHIIFNLTSPIPVVGASGAVAGVMGAYFLLYPHSWVLTFIPPVFVFRIPAVIFLGIWFIIQIMSAIGAGIFSSGSGVAWWAHAGGFLAGMILLPLFKDNKRCYYCYQAQKKDEFFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUE0</accession>
    <name>D6SUE0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871613.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0234"/>
    <dbReference type="EnsemblBacteria" id="EFI32920">
        <property type="protein sequence ID" value="EFI32920"/>
        <property type="gene ID" value="Dthio_PD0234"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191489at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="532" mass="61684" checksum="210B3FECED43CB8C" modified="2010-08-10" version="1">MERFFNNAGPTVPKDHYHIDPLHRLDWAEVQHLIDNKRYFVLHAPRQTGKTTTLLAMMKAINEKGRYHCAYANIEGAQAARGDETQGIPAACNAVARSIDYYLKNSKMREWLYQNINLIPSQDILSEMLAHWSQSSRRPVILFLDEVDALVGDTLISLLRQIRSGYAQRPEAFPQSIVLCGVRDVRDYRIHQTDGEIITGGSAFHIKAESLRMGNFSREEVKILWLQHTEETGQEFEDAIFPELWEDTRGQPWLVNALGYEVTWKARASRDRSRKISLTDYLQARENLILSRATHLDQLADKLREPRVHRVISALLAGEESVLQVPEDDLQYVTDLGLIERKREIRISNRIYKEVIPRELTSVAQDSISNQETAWYVKDDHSLDIPRLLEAFQQFFREHSEIWEDGFDYKEAAPQLLLQAFLQRILNGGGRLLCEYGLGRKRTDLIIEWPLDPQMGMYGPLQRAVIELKILRGNLEKTIQTGLEQTADYAERSGADEAYLFIFNRDRRVSWDEKIFRREETFNNREIIVWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUE6</accession>
    <name>D6SUE6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871619.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0240"/>
    <dbReference type="EnsemblBacteria" id="EFI32926">
        <property type="protein sequence ID" value="EFI32926"/>
        <property type="gene ID" value="Dthio_PD0240"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1527083at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="269" mass="29796" checksum="41C28C96736F49B6" modified="2010-08-10" version="1">MSQAKVLVVTGHGTNCHGETAYAARQAGADRVSICFFSDLTSEKENIRDYNLLIFPGGFLDGDDLGAAQAAALRWMYSSTESGRQIIRDLEEFYTDGGLILGICNGFQLLVKLGLLPAMDRAYFQRQVSLTHNDSSRFEDRWVHLGCNPGSPCVFTRGLDRLYLPVRHGEGKLVCRDETMLNSLEENNLVALKYIHPDTRGPTQEYPYNPNGSPSAIAGLTDPQGRILGLMPHPEAYNHPTNHPGWTRGEQDILGTEILARGIEYLHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUG9</accession>
    <name>D6SUG9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD0263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871642.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0263"/>
    <dbReference type="EnsemblBacteria" id="EFI32949">
        <property type="protein sequence ID" value="EFI32949"/>
        <property type="gene ID" value="Dthio_PD0263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03367">
        <property type="entry name" value="queuosine_QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI32949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="128" mass="14531" checksum="DF562976FB6DE4F0" modified="2010-08-10" version="1">MAAPRYCLRVSSDFSSSHQLRNYGGKCESLHGHNFQVQVQVCGKEVDPDTGMLMDFKELKNTLLAVLEELDHKHLNDLPHFKETNPSSENLACFVYQGLKKSLGNRGVYLDWVMVAEKDSSRAYYSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUK0</accession>
    <name>D6SUK0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871673.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0294"/>
    <dbReference type="EnsemblBacteria" id="EFI32980">
        <property type="protein sequence ID" value="EFI32980"/>
        <property type="gene ID" value="Dthio_PD0294"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="143"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="218"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="437" mass="49878" checksum="83265AF201E4F17A" modified="2010-08-10" version="1">MILDNSDGPHKDPLRRKAEEQLQDNPPDIDEAGLPPEKIRNMLHDLRVHQLELEMQNEELRSTQLELQTARDKFVRLYNQAPVGYLSLDKHGLIRQFNQTFMDMTGFTETEINGVPLADLMDHTGRETFLARYRALFKDPRNKNMEVNLRTPSRKYLPVRLAGRIEEHDLQGDGKDQDRYLLLIVSDITEQKQAREEIQRKKEQLEKTLAEKDRFFSILAHDLKSPLSGFLSSTRIMAEDINSFSLAELQNVSANMQRSAENLYSLLENLLTWARMQKGDTDFEPDVINLHDLVRQNMELSRSVFQHKEIIFESRISPELQIYADSNMIGTVLRNLLSNAGKYTHDKGRVVAGAEKKNGGITVYIQDSGSGMDQKTLQGLFQMNSKATQPGTRGESGTGLGLLLCREMIHRHQGEIWARSAPGKGTTFFFTLPGHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUM0</accession>
    <name>D6SUM0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsZ</name>
        <name evidence="6" type="synonym">rpsN</name>
        <name evidence="7" type="ORF">Dthio_PD0314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871693.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0314"/>
    <dbReference type="EnsemblBacteria" id="EFI33000">
        <property type="protein sequence ID" value="EFI33000"/>
        <property type="gene ID" value="Dthio_PD0314"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="61" mass="7193" checksum="5E7E955A2D8D5565" modified="2010-08-10" version="1">MTRKALMVKAHRKTKFSSRRYNRCPLCGRARAYMRHFGICRICFRNMSLAGELPGVRKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUP9</accession>
    <name>D6SUP9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871722.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0343"/>
    <dbReference type="EnsemblBacteria" id="EFI33029">
        <property type="protein sequence ID" value="EFI33029"/>
        <property type="gene ID" value="Dthio_PD0343"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="PTHR23264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="298" mass="31690" checksum="5A78E892D1801831" modified="2010-08-10" version="1">MIQEGRQGCNPGEAGHSADSRQSRSQEELLSSVLSRIRYKIFIMSGKGGVGKSSVAVNLAAALAAEGNRTGLLDVDIHGPSVPRLLGITGLLEVGNQSLIEPKRYNERLSVMSMESLLKDPDQAILWKGPMKTSAIRQFISNVRWGDLDYLVVDSPPGTGDEPMTVLKTIPDALCIVVTTPQEVSLADVRKAVNFLQYAKANILGLVENMSGMVCPHCSKDIALFKAGGGRALATRYGIDFLGSIPLDPASIDAAEKGTPVVLSSKPSPAKDAHARLAAKVDKAAKDSLEAVSTSHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUQ3</accession>
    <name>D6SUQ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome segregation ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871726.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0347"/>
    <dbReference type="EnsemblBacteria" id="EFI33033">
        <property type="protein sequence ID" value="EFI33033"/>
        <property type="gene ID" value="Dthio_PD0347"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875739at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="472" mass="54722" checksum="CD8D9BB09CE7EB56" modified="2010-08-10" version="1">MAKQKQSKQNRQSKKKRFQNESGQALKSLLSDQVESSLKREIGISQGESVPLSKEEQEEKKSRQDQSEDSQDEALAEGYDPKKMPGSKETKAQIMERMQNLVQEMERLERDYFYIQARLDQALQDKKEKDNELEQLRSQKEGLEDDLSSKVMLLSQHQNREKELKAELDRNIQAREELEEKLRARDKDLEQAIKDKDQQIQELKSEVDSNAQARKELEEKLKARDEILDQEIKDKDQQLLELKSEVDSNARIQKELEEKLQEKEKRLEQEAGEKGKLTEEVQSLKENAVELQEKISRLEQHNKGLEGEKKELLDKVEKMNKIGEDKSIQEESGGKMSANDWRNKADKLWNGVSYVAPQQAIEFLTAAIEKDPERAELHNDRGLANMDEYRMQESLNDFSTAVNLKPDFGEAYHNRGVVLLKQGKEFAARKDFQMAASHGVWMGLNYLQQPRHNPGVWEKILASLGFKKGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUU2</accession>
    <name>D6SUU2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871765.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0386"/>
    <dbReference type="EnsemblBacteria" id="EFI33072">
        <property type="protein sequence ID" value="EFI33072"/>
        <property type="gene ID" value="Dthio_PD0386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="8169" checksum="3409B8B5FE1D55C4" modified="2010-08-10" version="1">MHNKVKEVLTVRYAHSDGCVAAKIKEYPGCMTEVDDLADLEWNLYDALSSHTGRTIPEGSITWIWQEVSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUV3</accession>
    <name>D6SUV3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871776.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0398"/>
    <dbReference type="EnsemblBacteria" id="EFI33083">
        <property type="protein sequence ID" value="EFI33083"/>
        <property type="gene ID" value="Dthio_PD0398"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45029at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="816"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1311" mass="147111" checksum="23BCEB70DD62877B" modified="2010-08-10" version="1">MNQSITDTSSLWGQAFEIAVKRGVLAFLIKEELLSLSHQELSDWQNCRISSIKNSLLQELGIIDQTLQEHTEQALAHMFINGYGLGWSCIRQWLNTLKSSLKVRKKDKLTLDAIWCPLALPGKNRDSLTEHNDSFQQVGVNFLKCFNLDLTDNPGILAWKGGPARSDFTLMVTVNKKGSITHNLLVLEFSYFCPQATYDYSRENDHLEELSRYVGMMDKRGVFSRVTAELSQGKFDLSPTLSSHLAAFTSKDKPFYKLCQGASYVDTTLTLLKSQNIFKGPVNTKVMAVTSAGIESLSAEYLGETHDSRTMLMKQLGKTYRKTSIDKFSTQQQSDQALNKEIKMAFNQLLASLPADFKKQCKNLNELPIPGQSICYDFQEKLDRFYLPSTIVHSQEVEDLIGSDEKTDSYFIERTGKNAREIIGTEFSGLSTKGKSTLRDLHAAAVVSGLKAGKKGQVNVLALEGNPGIGKTTAVKNFLTDSDRQGYLFLYLSPRVVINKDVNAKFSSAGQDILTISTNAKLISNAASAYAHYYQVDGGESRINSVAIVRGVDDFTIPGSSTIWMAGPEMEDYIESYSGASRNRKTSLDERTDMVQEKPVPGVLRTIATSAGSLARENPGINRIVMTAALQSYKQTVKGSTIDSLSKIFVNDNPKSVPGKAERFKMAERFPNILVMLDEVAGDGSGSLFVHTITKWLERHFIDPFAGDTEGSPFTVHLIIADASLGNELIMESHLANESRAPEKVLISPSTGSYPFKPAVSSFKIGGRTRQVLHIMTNSYPATELSVRYLCKLHYIQPGERPDGTPMSIRERIRDQAEDLLLNSAKNEIMASVRKGAGQTIFFAQHKDFLTRIRDSLLEERSAEISDQLEFKPWEVAIIDSSVEPSKREQIIKPENRDKVRVFLMTSSGARGVSFPLATRIIAAIPRFNIESSLMELAQLIYRGRGHRTDSETGKVINCDEVPRELVMLIDDFLPIEDMKTDIRLWLRRSSDLLTLIIMLRGTIHTRITGDAGMSRKRFAIVPVGLIGLSELSTSMSKTVHDFITEGTTFKLREKTLTEEKKVVAAAVKNAVELFGGYDFQLNNPLNEQKSFSDMQEIKEFIRQAKSSTGKLIPGSSDSIPVLPDNIYCIGPFWLESWSKDDGKFMESQRFETFSADYTRKEKSFAGQLKHIGSNNRINTDLRRHAWDIYRLIARQNESIRLTYSSQKNIYSRHVWLSLPLNYPQFCRTVIDGSERAVNLKYPEEWKEALSRTMPHAGHYIPIIAEYETFPFAISLGSPDPARLDIIFDDRYFMASTELNLLNTLLLNDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUX1</accession>
    <name>D6SUX1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871826.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0010"/>
    <dbReference type="EnsemblBacteria" id="EFI32727">
        <property type="protein sequence ID" value="EFI32727"/>
        <property type="gene ID" value="Dthio_PD0010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="202"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="45591" checksum="79753FF3888BF0C1" modified="2010-08-10" version="1">MPKIHLTPSFVSNPPRVRNKAKVDYFDSDVPGFIMEVRSTGKSTYYQRYRDKFGRLKQARIAPVDSITLEEARQKAKQIRSQTTMGFDPRDEAEKNRNTPTFKEFIRDQYIPYIQVHKRSWDQDSKMLELRVLPLWGNMKMSEITRDDVQQFQSNFLRAGCKPGTVNRYMALVKYIFNLAEKWDVIEKTPARHISRLEDNNCKERYLSSEETKRLLGELKNCKSQVVPDIIELLILTGARKSEVVNLPWQELDLKQGLWTIPPERNKAKTRKTIPLSQGALRILEKRKHNGSEYVFPNPKTGGPIKHFHNTWDRVRKNAGIPDVRIHDLRHNFASLLVNSGRSLYEVQKLLGHSNISTTQRYAHLTQDTLRDATELAWSSIQNGQGESGSGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUX3</accession>
    <name>D6SUX3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871828.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0012"/>
    <dbReference type="EnsemblBacteria" id="EFI32729">
        <property type="protein sequence ID" value="EFI32729"/>
        <property type="gene ID" value="Dthio_PD0012"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="12126" checksum="A3EAEBB2309F4103" modified="2010-08-10" version="1">MSKWTVEFLNDSVEAEFDNLPPQVRAKAVQISKLIVEFGPAGLGMPYIRHVQDKIWEIRASHGRCLYISATGRKVVILRCFVKKSNKLPKKELKIAFERAREIDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUX9</accession>
    <name>D6SUX9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871834.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0019"/>
    <dbReference type="EnsemblBacteria" id="EFI32735">
        <property type="protein sequence ID" value="EFI32735"/>
        <property type="gene ID" value="Dthio_PD0019"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="311" mass="36200" checksum="076C5FD3AAEDAB53" modified="2010-08-10" version="1">MPRIARFIRNDRQTVYHVISRTALPGLPIKDTDKDYLLGLIKRLSRLYFVDVLGFAVMGNHFHLVARMHPEDEISNSDIIKRWQDYYGDKVEMPTDRMAEVKKRLCSLGAYVKDIKQNFTRYYNKKHRRKGFFWGGRFKSMIVQEGSTLVNLLAYVDLNPIRAGIVKKPENYRWSSLGYHTQTGNKDGLLDIDFGLKEWNELDPKEIVRKYRQFVYETGAVDAGKGKTIEKKVVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDERKFTPVGGVEGLYSMKRLGAGCDRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV06</accession>
    <name>D6SV06_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase IS21/IS408/IS1162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871855.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0052"/>
    <dbReference type="EnsemblBacteria" id="EFI32762">
        <property type="protein sequence ID" value="EFI32762"/>
        <property type="gene ID" value="Dthio_PD0052"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="362657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="111"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="491" mass="56659" checksum="1856BE980E1D17EC" modified="2010-08-10" version="1">MIDYELYARIKHYHEQKGLTPAQIAKELQLDPRTVGKWLEAKQFHQRKSVTRPSKLDPFKDTIVRMLEEHPYTAVQVLRSIKEQGYTGGSSILKEYISKVRPKRSRAFLSLAFAPGECAQVDWGNHGSIQVGDSRRNLSFFVMVLCYSRMMYLEFTVSQSMEHFLACHQNAFDAFGAVPRKIMVDNLKCAVLKHPFGQKPVLNPKYLDFARHWGFEISACGVRKPHEKGRVENAIGYVKKNLLAGLELPDYRAINHYARHWCRATANVRIHAQTGKKPVDMLEEEREHLLPLPVNTYDIGVLTQVRASSQFRITLESNRYSVPARYAGKRLTLKTYPDRLCIYDGNNLVARHVRSFDKKRDIEDPDHVQELIAQRRAARDQQLFSRFLALSPRAKDYFFELEKKHLNIKHHVQKIVALSEIYGSEAVSRAMDDAFTYSAFSCEYVANILEQRARTMPAPGALHLTRREDLLDIEVKDPDLSIYDKPKEKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV50</accession>
    <name>D6SV50_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module toxin, RelE/StbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871888.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0105"/>
    <dbReference type="EnsemblBacteria" id="EFI32806">
        <property type="protein sequence ID" value="EFI32806"/>
        <property type="gene ID" value="Dthio_PD0105"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="11418" checksum="D350AC5BD99C2738" modified="2010-08-10" version="1">MWTIKYLKSARKDVQKIDPQIRKRVREYLEQRIARLENPRQLGEPLKGQLTKLWRYRVGDYRIVCELRDHELIVIVVRIGHRKNVYKNYDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJR0</accession>
    <name>D6SJR0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylation/Crystallin J1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869238.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3565"/>
    <dbReference type="EnsemblBacteria" id="EFI36113">
        <property type="protein sequence ID" value="EFI36113"/>
        <property type="gene ID" value="Dthio_PD3565"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="28792" checksum="4E043BCF6109D626" modified="2010-08-10" version="1">MIGAIAGDIVGSVYEWDNIKTKDFDLFTSRSFFTDDTVLTVALADTIMTGRPYDENMRRFYKWYPGAGYGGSFHKWAKNPGLGPYNSWGNGAAMRISPVGFAYDDLDTVLKKAREYTEVTHNHPEGIKGGQATAAAIFLARQGKTRDEIKTYIENEFGYDLNRHVDEIRPTYQFDVSSQGTVPQAVRAFIDSSGFEDALRTAVSLGGDSDTLTCITGGIAQTFYKGVPEDIQVRVYRILDDRLRDITQTFMQRYCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK98</accession>
    <name>D6SK98_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869420.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3765"/>
    <dbReference type="EnsemblBacteria" id="EFI36301">
        <property type="protein sequence ID" value="EFI36301"/>
        <property type="gene ID" value="Dthio_PD3765"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="247"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="268"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="708" mass="80962" checksum="283348D6342053E2" modified="2010-08-10" version="1">MSQNQPTVAISSDFFNAFASLPKKVQNKAISFVSKFRQNPEIPGINYEKIHDAAHPGFRSVRIGDDYRGIVLKPDSDNVYVLLWVDQHDEAYAWARRKKCAVHPDTGSLQIFDVMEVSGHEVQQQEVSSAAVSGLFDEFRDRHLVQLGVPREMLARVRKITREEELDEMLGSLPQEAYEALFFLAQGFSLQEVFDQTGKTETEKEVDTSDIKTALDQPDSQQRFHVITDDLELQTMLQAPLEKWRVFLHPTQRKLVQRSWNGPVRVLGEAGTGKTVAAMHRARWLAREIFTGEHDWILMTTFTRNLAADIQSNLQTICSPEEQARIEVVNLDKWVSDFLKRSGYSYSIIYSHKTDELWEQAMAAAPEEPALPESFYREEWSNVLQPQGVASFEEYSKASRKGRGVALNRKARKTIWPVFEEYRLLLNENGWREPDDAMRDARNILEVQGLRLPYKSIVVDEAQDMGTQAFRLLRQMVPEGPDDLFIVGDGHQRIYRHKVILGQCGIKIVGRSRKLRVNYRTTEETRRWATSVLEDLVIDDLDEGRDDTKGTTSLLRGLEPDIKHFVSFEEEKKYLVQLARQKDAEGALARTCLAVRTKSMLKRYQQVMQDNAVPVYAISHDAAEDRNAPGLRLATLHRVKGLEFETMILAGVNDGVMPLRNSLESTDDAAERDDRELRERALFYVAATRARQELVVTSYGRQSPFIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKG5</accession>
    <name>D6SKG5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3839"/>
    <dbReference type="EnsemblBacteria" id="EFI36368">
        <property type="protein sequence ID" value="EFI36368"/>
        <property type="gene ID" value="Dthio_PD3839"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCD" evidence="4">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="117" mass="13917" checksum="E76FB764750DB6DF" modified="2010-08-10" version="1">MDEQDIVKLESILSEMDPELNLHELYHLDRHFHSQLYGYSRLSHLCLVVDKLMESVDIFLINRPRGSKYLIQMQAQHNQIIDALKNKDETMLKKSLKHNIKHGLRLIKKAYGPYIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKH1</accession>
    <name>D6SKH1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869490.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3845"/>
    <dbReference type="EnsemblBacteria" id="EFI36374">
        <property type="protein sequence ID" value="EFI36374"/>
        <property type="gene ID" value="Dthio_PD3845"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="313921at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="425" mass="46368" checksum="113A276FBD960642" modified="2010-08-10" version="1">MEIKLKYGKGVKMLRLPEHADVQVLTPRDLPHLSDLASSLQDALDAPLQAQSLESRPRPGRIAIAVPDETRPVPLKELLPVLLDRIFKTWPGIDPESVSIVVGGGLHPAPDSDQMARILPEDLRGCRAVSHDALSSPLKSYGFTSRGTPVEINAVFGEADLKIVVGMIDPHQYQGMTGGSKGVTIGCASRKMIEKNHSLMSTPGAVAGNIHDNFPRQDLNEAGRMIGIDLAVNVCLNSAQKAVAVLAGEPEAVLMSGAKITEQLYGLPLTEPFDIVIASCGGHPKDICIYQAQKGLNTASQCTVQGGRILLLAACTQGIGDQCYYDYVRRFTCPSSQIKDFEEFGFRMGAHKAYLYSRTLTRFTVVIDSELDAQTLADCHLTKGNAQETLDRWFQEQPPGFKPKVAVLPNANTSYFYKRKQLQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKK4</accession>
    <name>D6SKK4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">Dthio_PD2624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868349.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2624"/>
    <dbReference type="EnsemblBacteria" id="EFI35215">
        <property type="protein sequence ID" value="EFI35215"/>
        <property type="gene ID" value="Dthio_PD2624"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="417" mass="44241" checksum="F21EDAADA65B1614" modified="2010-08-10" version="1">MYKLVIEGGSRLEGEIRISGSKNASLPILMASIMADSDVILENVPGLKDIHTSLKLLTLLGCKSGYSEGSARIQAGELVPEAPYDLVRTMRASVLCLGPLLARLGRAKVALPGGCAIGSRPVDQHLRGLEQMGAGFELDSGYIVGKCKRLSGAHIIFDLPTVGGTENLLMAAALAKGETVLENAAREPEITDLAEFLNACGARISGHGTSVIRVQGVDSLEGCTYRVMSDRIEAGTYMVAAAITHGEVLLTNCPDKELDAVVAKLQEMGVVISPEPEGFRVSSNGDLQGVDVVTLPYPGFPTDMQAQIMALMCVAAGTGTIKETIFENRFLHALELNRMGARIKLSGQSAVVRGGADLVGAPVMASDLRASASLVLAGLRARGKTEVQRIYHLDRGYEVMEKKLEAVGAKISRQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKP6</accession>
    <name>D6SKP6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS200-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35257">
        <property type="protein sequence ID" value="EFI35257"/>
        <property type="gene ID" value="Dthio_PD2668"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="57" mass="6715" checksum="B4159B0C96B1ACD0" modified="2010-08-10" version="1">MKKSLGHSVWECKYHIVFVPIRRRKVIYGHLKTDIGQIIRRLCEYKDIEIIKGTACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKT0</accession>
    <name>D6SKT0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868423.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2705"/>
    <dbReference type="EnsemblBacteria" id="EFI35291">
        <property type="protein sequence ID" value="EFI35291"/>
        <property type="gene ID" value="Dthio_PD2705"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50344S7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040161at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="16592" checksum="8944B8F69F4F64F2" modified="2010-08-10" version="1">MARCAPTGFTLMEVLVALVIAGLVVGVFFQVLAAGLRLEFRSAEVVREVTEIRRIMDALMAMDVQDSEFAWSGEDFGLSWSLGIEPVETVHKRGDLPEEVRLPGELYRYVLAYSMDRGRQGRIVRYVWYEPGFFHEEFKRTHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKT7</accession>
    <name>D6SKT7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3 7">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3 7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868430.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2712"/>
    <dbReference type="EnsemblBacteria" id="EFI35298">
        <property type="protein sequence ID" value="EFI35298"/>
        <property type="gene ID" value="Dthio_PD2712"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1618609at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="6">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="183" mass="20842" checksum="3748FF1B7436EE4A" modified="2010-08-10" version="1">MDFIPTTLNGAYLIRLERHNDDRGFFSRTFCRREFEKMGLNSEISQCNLAFNNKAGTLRGMHFQTQPYSEVKLVGCVSGSVFDVIIDLREESTTYSCWFGTKLSADNLEMLYVPKGFAHGYQTLVDNAAVSYMVSESYCPEYENGVRWNDPVLNISWPLEVITVSKKDSAWPLLNIKKPKDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKV0</accession>
    <name>D6SKV0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tnp_DDE_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35311">
        <property type="protein sequence ID" value="EFI35311"/>
        <property type="gene ID" value="Dthio_PD2726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="49"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="16334" checksum="9A16141E2A404A14" modified="2010-08-10" version="1">MELTDNGYESDANHQALQEKGVDLIAPPTGKPPEGFRVMDFELSRHAFQEDQERINLFKQRAGGEAGFSQLKVNLGLRRLRCRGSVKSKFKIIMAVTSLNIKRAFNWMEGGSSGSRSRKKKDFKADTGILLFFYSYSVHIFVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKW2</accession>
    <name>D6SKW2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretion ATPase, PEP-CTERM locus subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868455.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2738"/>
    <dbReference type="EnsemblBacteria" id="EFI35323">
        <property type="protein sequence ID" value="EFI35323"/>
        <property type="gene ID" value="Dthio_PD2738"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="947558at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017466">
        <property type="entry name" value="ATPase_secr-sys_PEP-CTERM_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03015">
        <property type="entry name" value="pepcterm_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="422" mass="47672" checksum="9E07ED1762BC6728" modified="2010-08-10" version="1">MYASFFGFLEKPFNIIPNPAYLYPSSKHRMAITYLQYGLSENIGFILLTGEIGIGKTTLVRHMLADLNAKIEVAVLFNTNFAAEDLVKYVLREFEVEPAGSDKSANMDKLNSFLIHSYSRGKRPLLIIDEAQNLSLEALEEVRMLSNLQTDRDSLLQIMLIGQPELRMRIRDPRLAQLAQRIAVSYHLSPLSADETKEYIRHRLRSAGSLRDDIFTSEAMDLVHAKSKGIPRTINILCDAALVYAYADEVPTVDQHLMKQTIEDREEEGVVRDGAVWVDPEAVSGNGSGNAKGSQEAMNRIFSLESRVAEIAVQLNWQLSEMQARLDEGKDGVVQKLTELLSHERKKSDKLLMKFSHYRLKSRKMSGEHREIAGSITQEAKTDTAETGENYFPASSHEQHEDDVHVHPVPRTGFFRRLLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKY6</accession>
    <name>D6SKY6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868479.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2762"/>
    <dbReference type="EnsemblBacteria" id="EFI35347">
        <property type="protein sequence ID" value="EFI35347"/>
        <property type="gene ID" value="Dthio_PD2762"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1792151at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="11355" checksum="EFF3F2E6B01CC4D0" modified="2010-08-10" version="1">MSKDQLPKNYQMMQEQHPGFIKAVAELGNAVRQEGPLDEKSVELIQLSAAAALKLEGAVHSHARRALKAGATPEELRQTLIVLTSTTGFPTVASAMSWVRDVTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL01</accession>
    <name>D6SL01_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">crcB</name>
        <name evidence="11" type="ORF">Dthio_PD2777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2777"/>
    <dbReference type="EnsemblBacteria" id="EFI35362">
        <property type="protein sequence ID" value="EFI35362"/>
        <property type="gene ID" value="Dthio_PD2777"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="18504" checksum="65F7E573041D34BE" modified="2010-08-10" version="1">MEFPLVTAVMLMTPVVLYKRRFFYCISHALRVAFLLEKVMNKILLLALAGAFGTLLRYWLSVAMHSLLGPGFPWGTWTVNILGCFLFGLIWIMIQERGILPAHLRIIVLVGFMGAFTTFSTYIFECSALVQDTQWLKLGLNLLGQNILGFFALYLGFILGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL16</accession>
    <name>D6SL16_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868509.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2793"/>
    <dbReference type="EnsemblBacteria" id="EFI35377">
        <property type="protein sequence ID" value="EFI35377"/>
        <property type="gene ID" value="Dthio_PD2793"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233189at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="215" mass="23395" checksum="10901838E4D5003D" modified="2010-08-10" version="1">MDIINFTLNNAGLVLEYTFNHLSLVLIVLLISLALWISTGLIISWHDRLAGTVISLSNILFCIPSISLFGLFMTMPGFGLGRNTAVVVLVIYAMMPLVRSVYLGVKSVDASVVDAGKGMGMTPLQILLQIRIPMAWPMIFAGMRVSIVIVTGIATMATFIGEKNLGRLIHQGITRGDSDMIITGAIIVACMALLLDFIMARIQRRVISPGLRFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL57</accession>
    <name>D6SL57_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Filamentation induced by cAMP protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868550.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2838"/>
    <dbReference type="EnsemblBacteria" id="EFI35418">
        <property type="protein sequence ID" value="EFI35418"/>
        <property type="gene ID" value="Dthio_PD2838"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="130"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="220"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="221"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038925-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="387" mass="43368" checksum="B13FF63AC5BBA4FB" modified="2010-08-10" version="1">MKRDLTGTYYSTAAGGEKVRAFIPDPLPPLPPLSMDGETLNLMADAALALGRLSNLRLAPDYNLFLYQYVRKEAVLSSKIEGTQSTLVDLLAHEDDDIPGVPLDDVLEVSNYVKAVEYGKKRLLEDRFPVSSRLIKEIHAVLLTGGRGSDKTPGEFKRTQNWIGGTRPGNAAFVPTPPHEIQRCMGELDKFIHDRGHGLHTLVTAGLAHVQFETIHPFLDGNGRIGRMLVPLLLMQEGILDEPCLYLSLYLKRFREEYYARLQAVRMQGDWEGWMKFFLQGVIASARDAVSAAERIMAIYHEDRGHILDQGKSTKAVMRVHECILQRQAANPKKIAALSGLSQPSVMTALRVLESLAIVKESTGRQRNTRYHYIRTCKILNDEIGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL95</accession>
    <name>D6SL95_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868588.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2876"/>
    <dbReference type="EnsemblBacteria" id="EFI35456">
        <property type="protein sequence ID" value="EFI35456"/>
        <property type="gene ID" value="Dthio_PD2876"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1331839at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="27"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="29797" checksum="45CC3E5DB7E36756" modified="2010-08-10" version="1">MNIKPYLNYFQDYVQAFMDAAPAGDLNFELKKEHSLRVMEQARELASYHGFDPQSCFLTSLAGLFHDLGRFEQYWLYRTFNDKISVNHGLLSTKILHREKVLRKLSAPDKRCVLLSVLYHNRKSLPRTLAPGIRAVAGAVRDADKLDIYPIILHHISRDSKGSNTITLELEDANEVSPEILEQVRSGRLADYHRMRYKNDFLLLMSSWIYDLNYAYSCRRVLQKGYLDTIFAMLPQNSLMHSLRDSLLAYLQKYAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLE7</accession>
    <name>D6SLE7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">Dthio_PD2932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868640.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2932"/>
    <dbReference type="EnsemblBacteria" id="EFI35508">
        <property type="protein sequence ID" value="EFI35508"/>
        <property type="gene ID" value="Dthio_PD2932"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="286"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="334"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="404" mass="43643" checksum="DB0BB1C9C84C98E6" modified="2010-08-10" version="1">MIILVLNSGSSSVKYQLLEMQDKTLLASGLVERIGQSGSAYKHERLPGTDTSQVFSNEQDIPDHSTALDLVVKLITGEQTGVIKDVSSINGIGHRIVHGGEDFNTPILVDDDVVEGIRAQIPLAPLHNPGGLAGIETAKRLMPGIPNVAVFDTAFHQTMPPEAYRMAIPAELYSELKIRRYGFHGTSHLYVAKQCAATLGQTLEQTSCITVHLGNGCSMAAVKQGRCVDTSMGLTPLAGLVMGTRSGDVDPALHAFLTDKKGYSIQDIDNLLNKKSGLLGLCGDNDMRDIHARIDKGDSDAELALKIFCRRVTQYIGQYMAILDKTQAICFTAGVGENDERVRELSCATLSGLGVVLDKKRNQEVRRGEICEISSPESRVKVLVIPTNEELEIATQTAQVLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLF8</accession>
    <name>D6SLF8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868651.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2943"/>
    <dbReference type="EnsemblBacteria" id="EFI35519">
        <property type="protein sequence ID" value="EFI35519"/>
        <property type="gene ID" value="Dthio_PD2943"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="174"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="246" mass="27447" checksum="308478D8D8BE8F0A" modified="2010-08-10" version="1">MKIVFHKQFLESYATDPAAEEGRLDRARQVLQEEYEFIEPREASLEDILLVHTQAHVDKISRMEPIYSAAMLAAGGACMAADIAMQGEPAFGLIRPPGHHASPDFCWGFCWFNNVAIAVERLIHRGEINSAYILDIDLHFGDGTQGFFLGREDVIYQHMGDMDELPRELEQAGNPDLIAVSAGFDRHLLDWGGYLSTQDYQEIGRQVKDLAQNTCPGRVFAVLEGGYNHQVLGDNILALLQGLQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLG1</accession>
    <name>D6SLG1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FlgO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868654.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2946"/>
    <dbReference type="EnsemblBacteria" id="EFI35522">
        <property type="protein sequence ID" value="EFI35522"/>
        <property type="gene ID" value="Dthio_PD2946"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1457644at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041215">
        <property type="entry name" value="FlgO_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17680">
        <property type="entry name" value="FlgO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlgO" evidence="1">
        <location>
            <begin position="47"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="201" mass="22318" checksum="B79D96F32557461D" modified="2010-08-10" version="1">MTRYCTAILVCLILSIAAGCAWQGQNNDVRKIPEKQAEIIHDNHRAGYELHNMLVATLPQETTILLTTFVNLDNLEETSSLGRIVPHHIGTALTRCGHEIVDIRLRRDSLLVRQKQGEFGLSREIKEIARDNQANYVLAGTYSVLYNRILVNAKVLRSSDGLTVAATDYYLPYDSTVLDPAGFSGEQAAETIFTPNVLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLJ8</accession>
    <name>D6SLJ8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase I</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Single-chain monomer with multiple functions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868691.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2985"/>
    <dbReference type="EnsemblBacteria" id="EFI35559">
        <property type="protein sequence ID" value="EFI35559"/>
        <property type="gene ID" value="Dthio_PD2985"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLAc" evidence="7">
        <location>
            <begin position="654"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="914" mass="105136" checksum="E4C59E23A290B1C6" modified="2010-08-10" version="1">MTICDECRHKGQTRYNGKDRGELDILVVGDAPGKVDCRRGHYTASQYLAVLDQIRRLKPSYTVGQEFALGCKPEDSVKAQDISHCSPRLHEIVSRTKPKALLLLGVNAARAFGINKNQLAIRGNIIELNVEGHPVKAVASYSAGTAYKEPGLASCIQADVKKAAAIVDGTINNLDYQLETPETFEEIMSALEKAREATRAGTMKKLVSVDTETTSLEPYRLEEKMIAISLSWKKGQGLAFYFDHHEHGLNKEKQDQVLSKLEEVLDPEYTVTCAANAKFDYKWLNYRYGLDIPFFDFDVMLLEHLLDEDKKNEYGLKNLTRDYIPELAGYDEELEKALADIQNKFDKEAKEKHEQALQDYFTKWQEKTDEQRKELLKDWVRQRYIDLPEIEGLEKIKTVQNGRKKAVSKAYTKSLFKVLKKLPPEILDIPGSVARKVNYGDLPREILLPYAAMDAMVTRVIFTEQYRKMEEDYTQIKRLEIAEKTTDLAKTLRFMTMPLAPKISEMEYQGIRIDREKLEDFIARVDAKIPELKDRIFSSIGRKINLSSSSGDLKRVLFKEKRYEPVKYTKTGDFSTDKNSMEVLYEKNEDEFIRDLLILRRVEKVRETYFINWRGEIEYDGRLHFSLNQHGTATYRLSANKGLQNAPAYLKEIDLNVKSLFLPDSEEYDIFDLDIANAELRVLCGYSKDETLIEAFNQGLDIHSLTAAKISDFTYEEIKAAKEDKTSEQHKLRQLGKKINFGTVYSMGATSLSKQLWAESRIKVSEDEAKQYLNKFFEEYPKVKEYMEKTRAFARAHRFVYTYTGRRRRFPMLGVDNHQKFKAFRQAINCRIQTTSADIVNTNLVDLDDAIKPLGGRVLLTVHDSILFQLPKDTAGVTELLDQVITENTKNKFPWLPVEWKYDVGKGPNYGECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLW1</accession>
    <name>D6SLW1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868801.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3101"/>
    <dbReference type="EnsemblBacteria" id="EFI35672">
        <property type="protein sequence ID" value="EFI35672"/>
        <property type="gene ID" value="Dthio_PD3101"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1500398at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="160" mass="17824" checksum="889BC03A1E1A2E97" modified="2010-08-10" version="1">MRHVLSVLVENEPGVLSRVAGLFSGRGFNIDTLNVGPTLEKGVSLMTISTHGDEQIIEQIIKQLRKLITVIKVVDLSDTKAVEREMVLIKVHASENSRAEILRIVDIFRCKVVDVSTDELTLEVTGDQGKINAMVNMLQRFGIKEFARTGTVAMKRSMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLX5</accession>
    <name>D6SLX5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">MPT synthase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Molybdenum cofactor biosynthesis protein E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Molybdopterin-converting factor large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Molybdopterin-converting factor subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD3115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12160"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868815.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3115"/>
    <dbReference type="EnsemblBacteria" id="EFI35686">
        <property type="protein sequence ID" value="EFI35686"/>
        <property type="gene ID" value="Dthio_PD3115"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1622957at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13443" checksum="FF469C8358A5DECC" modified="2010-08-10" version="1">MDISKAIAELKKEEGFTENVGMVLVHNGVVRAWSRKDRSLVKKIEVTPDHDRVEAIRQRYEKSQGIFRIVVQANSGILEPGDDLLFIIVAGDIRENVKPVLSDILDEIKKEAISKKEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM13</accession>
    <name>D6SM13_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="10">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="10">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glyS</name>
        <name evidence="12" type="ORF">Dthio_PD3153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868853.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3153"/>
    <dbReference type="EnsemblBacteria" id="EFI35724">
        <property type="protein sequence ID" value="EFI35724"/>
        <property type="gene ID" value="Dthio_PD3153"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="213210at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="583"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="695" mass="78563" checksum="8DFF01511D1D23A1" modified="2010-08-10" version="1">MPDFVLEIGFEEMPARFLKQITIDFRQSLDKELETQMLDHGQVRTWSTPRRLCAYVSGLSEVQTSKEEIVTGPPVAVGLDEQGGYTKAGQGFARSQQVDVQELMIQETEKGRYLAVQKKVGGAQTRDILPQICTEAVNSLGFPKKMRWWDRFTFGRPIRWILAKMDEQVINFQIADVKSADMTYGHRVLGPGPFRVDQAKDYFRIIREEAGVILDFQERKDIITSEASNLAREIQGKVVENEKLASENANLAEFPGPVLGSFDPGYLELPREVLLTSMESHQKSFGVVDDEDRLLPSFVAVINNRPDSRGLIRKGWERVLKARLEDARFFWNSDKAASFDEWMQKLEKVVFMAPLGSMGEKSRRLERISGFLCDRLQSADKKDVQKAAFICKADLVSEMVGEFADLQGIMGGIYASHAGYNDNVARAVYEHYLPLGPDSDTPSTPEGALVSLADKMDNLVGCFGLDMLPTGAADPYALRRQALGVIRIIIKHGLRLDIEELISFTAKSYTGATWKQDPEQALEKLMQFFATRLKAYWQGQGFQGKLVDAVLQSGFSDIYAAQGRLDAIREFSLDENFEAAVLTYKRVDNIIRKQAGDAGVSLKQDYDPGLLQEDPEIKLDRAIREIMNDWDTLWQNEDFSSLFNKLNALRPSVDDFFDHVMVMCQDEKLRQNRLGLLNFLSLKFKKLADFSALQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM59</accession>
    <name>D6SM59_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868899.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3202"/>
    <dbReference type="EnsemblBacteria" id="EFI35770">
        <property type="protein sequence ID" value="EFI35770"/>
        <property type="gene ID" value="Dthio_PD3202"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="102" mass="11583" checksum="1989FE1AC862AA37" modified="2010-08-10" version="1">MKKLDPITPGELLLEEFLKPMGLSQYRLAKEIDVPPQRISEIVSNKRSISADTDLRLCRFFGLSNGYWLRAQAAYDTEVAERTLGPLLNKIKPWSESSAQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM81</accession>
    <name>D6SM81_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="10">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="10">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">folD</name>
        <name evidence="13" type="ORF">Dthio_PD3227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="10"/>
    <dbReference type="EC" id="3.5.4.9" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868921.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3227"/>
    <dbReference type="EnsemblBacteria" id="EFI35792">
        <property type="protein sequence ID" value="EFI35792"/>
        <property type="gene ID" value="Dthio_PD3227"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="1 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="11">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="12">
        <location>
            <begin position="123"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="282" mass="30334" checksum="74BC4894329CE92B" modified="2010-08-10" version="1">MQDKILDGKGVSAKIKEELAEEIKELQKKNVTPGLAVVLVGEDPASQVYVNMKEKTCNALGIVSRKHVLPEDVSEEKLLSMVDDLNNDPEIDGILVQLPLPGHIDENKVLDRIKVEKDVDGFHPESIGRVVLAQDGFRAATPAGIIELLKRSNVTLEGKEAVVLGRSNIVGKPVALLLLNENATVTVAHSRTKDIAEVTRRADILVVAVGRKEMVTADMVKQGAVVVDVGIHRVEDGLKGDVAFEEVKEKASAITPVPGGVGPMTIAMLMSNTVKSARKRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM83</accession>
    <name>D6SM83_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868923.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3229"/>
    <dbReference type="EnsemblBacteria" id="EFI35794">
        <property type="protein sequence ID" value="EFI35794"/>
        <property type="gene ID" value="Dthio_PD3229"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02790">
        <property type="entry name" value="MopB_CT_Formate-Dh_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041925">
        <property type="entry name" value="CT_Formate-Dh_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="3">
        <location>
            <begin position="2"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="4">
        <location>
            <begin position="413"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="528" mass="58793" checksum="92283F38216F4D3A" modified="2010-08-10" version="1">MTNSYEEIKDNDVLLVIGSNTTETHPIIGLEMKKAVRRGAKLIVIDPRKIELVRWSHDHLQLKPGTDVALLNCIMNVIIQENLADKTYIDERTQGYPALARSLEGYTPEYGEEVTGVAREKIIDAARTYARASKAGIYYTMGITQHTHGTDNVFAIANLALMTGNLGRRSTGVNPLRGQNNVQGSTDMGCVPPFYPGYQSVASPEVKARFERLWRAQLSSTPGLTATEMVDAAAEGNFRALYIKGENPVVSDPDMQHTVKALQNLDFLVVQDIFMTETARMADVILPAACFAEKEGTFTNSERRVQRVRKAVEPPGEAREDSWIIASLSSSMGYDISYDRIEDVFQEAGKAWPALGGMDYQRLEHRGLQWPCPTSDHPGTPYLFKGAFPKRIPAFTPVDYRPSEELPDSEYPLVLNTGRELFNYHTGTMTRRSPAVNKVMPRGYVEIHPEDARRLGIDKDQLVRVSSRRGSIDIHGLVSNRPLQGTVFIPFHFTEAAANMLTNTAVDPIARIPELKVCAVKLEPIENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMD6</accession>
    <name>D6SMD6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868976.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3285"/>
    <dbReference type="EnsemblBacteria" id="EFI35847">
        <property type="protein sequence ID" value="EFI35847"/>
        <property type="gene ID" value="Dthio_PD3285"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="281" mass="31634" checksum="7B00592449A6EEBE" modified="2010-08-10" version="1">MNSEQILPSNPLSGGVVQDMDPNKKISLDQEHCCLEVKDLNLFYGSTQALKSINMEIPVKRATAFIGPSGCGKSTLLRCFNRLNDMIDICRVQGEIKLDGENIYDPKVDVAELRRKVGMVFQKPNPFPKSIFDNIAFGLRLKGIRNKKHLSEVVEKSLKGAALWDEVKDRLHESALGLSGGQQQRLVIARAIAIEPNVILLDEPCSALDPISTSKIEELIYYLKESYTIVIVTHNMQQAARVSDFTAYMYLGELIEYRDTITMFTNPREKTTEEYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SME1</accession>
    <name>D6SME1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868981.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3291"/>
    <dbReference type="EnsemblBacteria" id="EFI35852">
        <property type="protein sequence ID" value="EFI35852"/>
        <property type="gene ID" value="Dthio_PD3291"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="372"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="592" mass="67625" checksum="9A3251D8B61F3F23" modified="2010-08-10" version="1">MQREFSLKVKLIVSFWLVLVFSLAVPSNYFIQSVEQKVDSQHLQYVQERMEIVQWIIAQEEEKKPEKLDSILKSLDFLDDARVSVLDAQGMIIADSRQHREEFEGMSSYIDYPEVVQARHETGYHTASDPWEDDRRLYMATRIDLSSEQEDTGYLRLVTPFSGLHPYFQHVSANLWKFVLLSLFLSCIVVYLMVTYLTFRLKPMIKMAQSIGQGNFQQRIQDSPGREFDPLVEAINRMAEDVEKSMELVSSQKSDLETIVNGIKDGLAALDNQGRIISCNQSFKKIFQHLDTINGKKPVEIFFNNSLQAACEEVLGNSMKQTRTMELEIKEKFYDVHVVSPSDQQNIGAIILLHDITDLKNLESIRKDFVANASHELRTPLTSIKGYTETMLQHPDIMQEKGTELLQVVIKNTDNMIRLLDDILQLSRIESTQDQVALDDVDLAAVIFKSWNNCSHYTEGKNIVFESELEQEGQLLVRGEAEYLGQVFQNLFENSIKFVPGEGFIQVLVRQEGNQVWVGVQDNGPGIPAAEQQRIFERFYRVKKDKKKVKGTGLGLAICKNIIKAFGGRIWVESPVPGSDSGCIVWFSLNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMF7</accession>
    <name>D6SMF7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smr protein/MutS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868997.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3307"/>
    <dbReference type="EnsemblBacteria" id="EFI35868">
        <property type="protein sequence ID" value="EFI35868"/>
        <property type="gene ID" value="Dthio_PD3307"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1888882at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="226" mass="25800" checksum="FC6F69D18BD1C234" modified="2010-08-10" version="1">MKSLKELKKIKISSRKKEKNPEPPAPPEKKKDKSEENLFQTAMSGVKPLKGKGRDIPLETEPAAEGAPLQEESDLDTLYRLVRGDVEFDVQFSDEYIQGYVKSINTRTFRRFKNGELSIEAHLDLHGLNSDQARQELLHFMREQYHQGKTCVLLIPGRGKNSPLGEGVLRNEIQSWLTVEPLKRIVLAFCSALPRHGGTGALYVLMRSKKKTKGKIHWDKYLIDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMF8</accession>
    <name>D6SMF8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="8" type="ORF">Dthio_PD3308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868998.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3308"/>
    <dbReference type="EnsemblBacteria" id="EFI35869">
        <property type="protein sequence ID" value="EFI35869"/>
        <property type="gene ID" value="Dthio_PD3308"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="241"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="323"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="387"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="435" mass="48895" checksum="7C06ABB47F891FC6" modified="2010-08-10" version="1">MGFFSKIKNLWKSDAQETTEKPEIKDKPSPATPDAQEQEWQAALKQSLAAAEPRLSVWLDHLLQGVDSKGELLWQRLYFFFDALEIPREEAEDFVARFSKWLDDMGYTDLEEFRSELQYRLALALDLEDEEDEKSRLFIKLSHGLSKTKAQLSRQIDQLLSSSTSFDEAFWEELEEILIMSDVGHKAATELVQKLRTEVSGQSVDDPQEFKQLLGKELAAFFPRPQKRIKPDPPEVILMIGVNGVGKTTTIAKLAHRDRMKGRRVMIAAGDTFRAAAIEQLGIWAERADAEFYAKSHGADPASVAYEALDKAVAEGTDVLYVDTAGRLHTKSDLMQELKKMKSVMQKKRPGSPHRTILVLDATTGQNAMSQTELFAREINIDEIILTKLDGTAKGGVMVAIALQHQIPITFIGLGEKMEDLRPFEPESFARALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMJ2</accession>
    <name>D6SMJ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869031.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3342"/>
    <dbReference type="EnsemblBacteria" id="EFI35903">
        <property type="protein sequence ID" value="EFI35903"/>
        <property type="gene ID" value="Dthio_PD3342"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1064872at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="351" mass="40877" checksum="97A0D8A8E682E4CB" modified="2010-08-10" version="1">MAGIEFKVHHQQSLFHNPFQDMQLTTQDLEVRTDPLTGHQSVLNTGLEGKAQILFPDTDYEYLEQRGQETARTCFLCPKDWKKNTPAYPEEFLPQGRLEHGQAALFPNLFPIGAYHSVIRLGDKHLRKLNDFPVQLLADGFSVALDFVRKCHGYDPEMRYATLNANYLFPAGASLVHPHFQIINSPTPSTHHELILQKCARYHEQHNSCFWDDLLQQEKARDERWIGTTGNACWITAFAPMGYNEIQVVWPDRQNFLQWTHQDVQDLARGLNHVFNVWHEMSLSTFNFTCFSAPLDQDSPHFCCMMRLVNRQNVAPHHRTDDYFFQKLMQNELILNRPENMARKMREAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMM2</accession>
    <name>D6SMM2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869061.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35933">
        <property type="protein sequence ID" value="EFI35933"/>
        <property type="gene ID" value="Dthio_PD3375"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2069467at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="81" mass="9357" checksum="0CF9191BE1C5E55A" modified="2010-08-10" version="1">MSNPIQCPGSSTRNLEVDLISCQDCGHEVEMFSDETKRRCPRCKKMVFRDRMPSCVDWCPSAKECVCEERWQAMHAGKQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMN1</accession>
    <name>D6SMN1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.399</ecNumber>
            <ecNumber evidence="6">1.1.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD3384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="5"/>
    <dbReference type="EC" id="1.1.1.95" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869070.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3384"/>
    <dbReference type="EnsemblBacteria" id="EFI35942">
        <property type="protein sequence ID" value="EFI35942"/>
        <property type="gene ID" value="Dthio_PD3384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="327"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="43489" checksum="E0C5204891BDE659" modified="2010-08-10" version="1">MRILANDGLVDEAVNFLRREGFSVDTEKRDYEDLLGDLPDFDALLVRSATKVNRELIEAATTKRGKLKIIGRGGVGTDNIDLQAAKECGVVVKFAPHGNINATAEHVIGLMFAIARKVPFAHHTLKSGIWHKARFKGVELQGKTLGLIGCGRIGQAVANKAKDLDMKVIGFDMQRWMDSEVDYMDSMEEVLDHADFVSINTGGAHTLIREPELERMKSSAFLINASRGVNVEEDALYYALKNGRIAGAALDCYEKEPKREGEPFTSKLAELDNIVLSAHLGASTANAARKTGMEIADVVSKYLKYGDFRQSVNVGQTVIDEGIDLYTIFITHEDKPGMFGKFGTAFGDLGVNIQENNSRRLDGLAQTIYTIQEKPTSEMQEKLLEIDGVRRVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMQ6</accession>
    <name>D6SMQ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ORF">Dthio_PD3409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869095.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3409"/>
    <dbReference type="EnsemblBacteria" id="EFI35967">
        <property type="protein sequence ID" value="EFI35967"/>
        <property type="gene ID" value="Dthio_PD3409"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="297" mass="33423" checksum="D107565A1E419667" modified="2010-08-10" version="1">MSTQVLLAESAGFCMGVSLALGKLDKALENQTSQRIFTYGPIIHNPQVLEYYHGKGVKIIDNWDEPRPGDMVLIRAHGVPLQVEEKLREKNIDILDATCPKVKKAQLLIYKNSAVSDRLLIYGELDHPEVKGLLSYAQCEAFLFENMQEFKKIALAPKDRYCLVSQTTQDRQEFLSIASELKHSQGNEIITLDTICDATKDRQNETIKIAGQVECMFVVGGRNSGNTRRLYQVARKYCPRCLHIETKEEIDPEMVKGCSKVGLTAGASTPNSTIQSIYQYLHRIINSQDPSLTTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMU0</accession>
    <name>D6SMU0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869129.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3443"/>
    <dbReference type="EnsemblBacteria" id="EFI36001">
        <property type="protein sequence ID" value="EFI36001"/>
        <property type="gene ID" value="Dthio_PD3443"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="305" mass="34395" checksum="5FA2518292808D3D" modified="2010-08-10" version="1">MHENAFDRVLVFGEVLFDIFPDQSRVIGGAPFNAARHLQGLGLDPFFVSRVGRDAPGEEVREQMQLWGMNRQGLQVDQDRPTGMVLVRFKGDEPYYEIKEEVAFDYIEQDQEQSSFEGRTLFYHGTLAARSSISASTLYALAQKKDQEVFCDINLRDPWWSRELVRDILSWCSYLKVNLDELEEVASILEIREEGLQARARMVQKVCGLKCLVLTMGGDGAMLFPGDREHLFAAAPKVSSFEDAVGAGDSFSAIFLMGLCRGWSWESILQRAVRIAAEVCSIKGAVPEEKDFYSRFARSVMHDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMU7</accession>
    <name>D6SMU7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869136.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3450"/>
    <dbReference type="EnsemblBacteria" id="EFI36008">
        <property type="protein sequence ID" value="EFI36008"/>
        <property type="gene ID" value="Dthio_PD3450"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2044449at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="716" mass="82710" checksum="F81E65E8357E0B34" modified="2010-08-10" version="1">MARKGKRSKKGKPARSPSKKLEARLLGYWKKEAWEEFITLYQRHRDTASKTSAASCWNPAIYNLLLKTLVHHQKIETLENVHKGLKQAPDLNSENTQCLNVVQALIDVYHGRGYPGMADSLPRDLPDPFAELAQGLREILCGNMSALHLYVQGGLTRARKNEKHLSLAARAAREFNNLAAINFQTPSVKPLTRIRKHFQELHDYFTTNFQEKSVELKNLRVLAEAMHLLYSRPGHFMDPHSVQGYLHRSGFSQSSHPAVTAMYQAFLTLGGNIMGRNWKDTASYGLQSYAPEAQSDLPSHVQGQLAALSRIRKKDTDSLYILQELLDFDVWSERERMILLQARMQQMVERFEEFFDYLHDLAMEDGEKQARKALKDHMQQSCSDLQEIAELYQKLGLSNESIISTPFKYWFDFYQELAFLDNYMLLDRLIKNLCDLPVPDSVFLGLIYKRSEQSPAPEALESLKKIQQKRAPLKISHQEIKDYVLVLPGWMYTEKILRGWKACLSREDYRFAIETLLVSILDHEFQSLYSPSYRETDWFLWEEIPQHLLEAFLKELGPESPVFGLLNLSANTSGRTMPANAKEADFFTKYMPPPDTLHKIILWMLTWPSSPYKNKFMAQLIKHNLEHFNRIEAWDHLVKVIAYKKMKVLAGMVRDIWAEKDLFTTLASHQDFQNAVNTMNAKFPQKQAKGGKKGKKQALKQNSMLDLMQDQEKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN36</accession>
    <name>D6SN36_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase central domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869222.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3545"/>
    <dbReference type="EnsemblBacteria" id="EFI36097">
        <property type="protein sequence ID" value="EFI36097"/>
        <property type="gene ID" value="Dthio_PD3545"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="280"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="528"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="738" mass="84536" checksum="C439451B7F47D913" modified="2010-08-10" version="1">MPGPGGESRPQIFERAPESVFKMDADDFFIRQKSAVYMRRTLEMMKRMDEPALEFVNWIVAGSQELKNLLMSRLGTKEKERILGEVRAHTFHTVEAWKEVDFLVSALEATQPRHHGHILKGVKIILDEYLSSVQEPNCPILENLASIQETFRLSEHESELILFIFLTGVHKPFDDYFSEHLDSQAYAGRKYLAGALGLNYSQLQEAMSGQLFELGLLRRNFNLLDLDEDISRTLAQGKAHRLNSNYFVKAAEDFINLKHHLLPAETIHHLLGLLKEKRNTPVHILLYGSPGTGKTTFARAIAHKINCPAYEIVHPEDNSGHGLRKAVQACVNITNEGQGALMIVDEAESLLETGSSFFQKGEVRDKGWLNRFMDRPGIRALWITNHVEDIQESTKRRFSFSLGFKKFNRSKRTALWNTVLDQNMAAPLMTKKQIQTLARDYDVTPGAMNTAVINSRELAGNRHGFYAAVRRSLDAYQDLLHDGIRPEPNESLQKDYSLEGLNFKADLEDFTSRMEKFSRNMSGSQEAFGINTLFYGPPGTGKSELVRYLGQKLDRELLIKYPSDILDPYVGMNERNIADAFQDAARDESILVFEEVDSFLSSRNMAQRSWEVNMVNEFLVRMERFKGILICTTNNYSWVDRAALRRFLFKVEFDYLHPRGRQIFYRKIICPLLENEPTRGEMDLVKGISRLTPGDFRVVRDRYRLLPGSELSHAGLIQALELETRMKDKHEGIKRLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN75</accession>
    <name>D6SN75_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869529.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1552"/>
    <dbReference type="EnsemblBacteria" id="EFI34201">
        <property type="protein sequence ID" value="EFI34201"/>
        <property type="gene ID" value="Dthio_PD1552"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2214290at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1288" mass="144031" checksum="17577AC608B1B63D" modified="2010-08-10" version="1">MSIIFPPVGQVELGLPFSELFQDTDPEATHYQLWTGLIEDGEVKKGFTLRAADGSPWIPVEELDNMSVGINQLEHNTLYVRNYSTEVGDWAKRDDVPFPSEISIELQEETNVVGEDTPLSDMFSYEAVIPEDQIWFQVTVDGEHLDTRLGRGWVRGDHLDEELFPAQAAGSEISVLPYYAGDIQTQEKKSWNVAREQEFEFFIDRYYLTQDTSLNDLFSFISPTGFEADSIWFQVTAGGEPLDTQVGHGWVRGDRLDEEILPRADAGKEISVVPYYAGDFQENEQVKWLVTDRPAELGFAEDAVLISPESPEVGDDITFSSQVFETDGVETVELWAELTVYNGQGQTVHSDEVSASFQIQEDSYNFEFETWDDAIEGEYTASVTVDALNADSLNAEFDFEVLDPAPAFFSVQEVDAPDVVQGEHASVSVDIKNTGDLPGSQDILLVVDPDGEELEFPSDEPLELAGQEAGEVQFTGLDLHGLEAGSYDLLVITDNDEKKFGDHLNILAPAYFSIDEDSIKDLVIKEGQQQADFSFDVSNSGEVSGKQDIELVIVREDQDDLVEVLEDFNLQAGETKTAHFEISGIEDLTQGSYDFQLSTEDEQITVPSALLVRDPDQAWASVEAVDPVFEGSQEVTAVFTVDNIHEFQGDVFVAVTDDAGQVLSDEKRIDEDLESETFSFELFEPLMAKETLTVGIYEDSELSEELDSSEVRVPESARFVVQSFELDPVLEGDILEVTADILNTGELQDTQDIILELDGDQIASQEMMLGGGDSKEFAYNLDTSDLELQPGDYQLALSTDQDSQERDFTVLAEPYFDIMDFVDVEVARGQTVAISADIHNTGDVQANRQVMLYLDDIELESFEMTLEGGESAEFAFELDSSDVQGDMLDTGEYTLGLDTEDATSNALLNVFERPVNILQAESGVDEQTLAGDTESQNAFVFEFDSSQDGPLADFGDVLIENYQPDDLILFLDQENIWNASSDFNDYDILSSRDDGVEISFSLVPPFSNQIFIEDAELDERVPWSYLDDIKDVHIEVEHTEVVQQSGMEEYIRNILYPEQHTVSFNITDDNDESLENVNLVIENSDSYQVVTDEHGYAEQKITDGQYNFTARLPGYDYYEGSFEVDGDDKQIDLEMEEAVFNVVEIESDPERQETIYGDPGMRDFYVLEFGSSPDRAQADFGQVNIGDYSHDEGDYILLLDEDNNWSSTQEFEADSIQDSDEGALINFINSPGDPEQWLQIDGTRVDSQDPPFVWSIEDIEDVRFVVEESATVEAMGIEQYILQEVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN92</accession>
    <name>D6SN92_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869546.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1569"/>
    <dbReference type="EnsemblBacteria" id="EFI34218">
        <property type="protein sequence ID" value="EFI34218"/>
        <property type="gene ID" value="Dthio_PD1569"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="260" mass="29914" checksum="34EBCB837AD34056" modified="2010-08-10" version="1">MQTIIFCGGSGTRLREETEYRPKPMVNIGKRPILWHIMKIFACYGYQNFILPLGYKGNIIKDYFLRYETMNNDLTLELGRPEAIQMHNCHDEAGWRITLADTGEHTLKGGRLKRVQRYVSGDEFMLTYGDGVADVDINKLLEFHRSHGKIATVTGVRPLARFGELNAQGDRVVSFREKPQIASHDGLINGGFFVFSRAVFDYLTPEDNCDLEHGPLEVIAAAGELKVFRHDGFWYCMDTMRDVDVLNRMWEQGQAEWKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN93</accession>
    <name>D6SN93_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869547.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1570"/>
    <dbReference type="EnsemblBacteria" id="EFI34219">
        <property type="protein sequence ID" value="EFI34219"/>
        <property type="gene ID" value="Dthio_PD1570"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="406" mass="46271" checksum="D3A33313969B38DF" modified="2010-08-10" version="1">MKKRVLILGGDGFCGWPTSLYLSQQGYEVTIVDNMSRRMIDIELGCDSLTPISSIFKRIDRWKELTGKDIDFYNFDISRNYHRLLTLLKEFEPDTVVHFAEQRAAPYSMKSSYHKRYTVDNNLNGTNNLLAAIVESKLDTHVVHLGTMGVYGYQTAGLKIPEGYLKVKVETREGEKELDIMYPPSPGSIYHMTKTQDALLFYFYNKNDGLRVTDLHQGVVWGTETDETRMDETLINRFDYDGDYGTVLNRFLVQAAVGHPLTVHGTGGQTRAFIHIKDTVQCIKMAIENPPDFGSSVEIFNQATETHSVGYLAELVSQNTGAEIRYYNNPRKEATANELKVKNDKFLNLGLSPVKLKNGLMDEVMYIVDKYKYRCDMSKIPCTSCWCEDMEVDREGRSATENRTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNB3</accession>
    <name>D6SNB3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HicB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869567.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1590"/>
    <dbReference type="EnsemblBacteria" id="EFI34239">
        <property type="protein sequence ID" value="EFI34239"/>
        <property type="gene ID" value="Dthio_PD1590"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="10927" checksum="26EBC1905DD7A2FD" modified="2010-08-10" version="1">MTHDKKKEYSGQFRLRLPRDLHARLAEEASRQGVSLNGYVVYLLSSNLSQAQTSAYFEEKIADTVMEVHEMVSSMTVGDNEPGEMVWANSGSSSLVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNH0</accession>
    <name>D6SNH0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="6" type="ORF">Dthio_PD1647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1647"/>
    <dbReference type="EnsemblBacteria" id="EFI34296">
        <property type="protein sequence ID" value="EFI34296"/>
        <property type="gene ID" value="Dthio_PD1647"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="44" mass="5407" checksum="A85C6B924A07213E" modified="2010-08-10" version="1">MKRTYQPSRIKRKRTHGFRVRMRTKNGRAIINRRRAKGRKRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNK2</accession>
    <name>D6SNK2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869656.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1679"/>
    <dbReference type="EnsemblBacteria" id="EFI34328">
        <property type="protein sequence ID" value="EFI34328"/>
        <property type="gene ID" value="Dthio_PD1679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087898" evidence="2">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="65" mass="7282" checksum="4AAC54081B85E39E" modified="2010-08-10" version="1">MWYKGFLLTLAAILMLGFSMGCEPDHEDPMEDPGAPEGYEEPAPEEYEPPENDEYGEPGEEEPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNV8</accession>
    <name>D6SNV8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869756.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1793"/>
    <dbReference type="EnsemblBacteria" id="EFI34434">
        <property type="protein sequence ID" value="EFI34434"/>
        <property type="gene ID" value="Dthio_PD1793"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="32"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="226"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="367" mass="40846" checksum="F38515D0A644AF2A" modified="2010-08-10" version="1">MNFTDFELDHRIQAGIKACGYKNPTAIQEQAIPVGLQGRDVMGLAQTGTGKTAAFVVPALQRLLQGKRGKPRVLVLSPTRELAEQTHEFFTALGRKTGLRCVSVYGGVSRSGQVQKIRSGVEIVVACPGRLLDLARDRAVNLSQVETLILDESDRMLDMGFMPDIRSIMKMLPPKRQNMLFSATMPADIRTLADEILDDPARVQVNHERALDSISQCLYPVKRRPKAEMLIELLREKQDGATLVFTRTKHMATRIAKRLSQAGFRARDLQGNMSQNNRQRVMKDFKRGSFNILVATDIASRGIDVAGIGHVVNFDMPDTAESYTHRIGRTGRADSCGDASTFVEPKDFGLIRAIERLQSQKLQRKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNW8</accession>
    <name>D6SNW8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSP1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869766.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1803"/>
    <dbReference type="EnsemblBacteria" id="EFI34444">
        <property type="protein sequence ID" value="EFI34444"/>
        <property type="gene ID" value="Dthio_PD1803"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1523756at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="276" mass="32008" checksum="2E4CE22D5FC18764" modified="2010-08-10" version="1">MSQIAGVKFRDQGQIYYFQASPFVVKPGDGVIVKTQEGLGLAIVVQVRDTLPEGFALEDLKPIFRLANEEDFKVQEENKELGREAFAYCKKCLAERELDMKLVDVEVFFDRSKIIFYFTAPGRVDFRDLVKELVKVYRTRIELRQIGVRHETQMVGALGNCGQVCCCRRFMRQFAPVTIKMAKDQNLFLNPAKISGVCGRLLCCLNFEQPHYAQFQKKLPKMGKRYKCREGYLRVIRANLFRESLTVLDEEGTEKEVPLQDWQQMLQKPDKKKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNZ3</accession>
    <name>D6SNZ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase small</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1828"/>
    <dbReference type="EnsemblBacteria" id="EFI34469">
        <property type="protein sequence ID" value="EFI34469"/>
        <property type="gene ID" value="Dthio_PD1828"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="PTHR14614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="243" mass="27684" checksum="9D1B68ECCFD30D6B" modified="2010-08-10" version="1">MQDTDFLQTESMDELLARARERYEVTFEPVRIKDMTLEILQIADMEAYIDQLAETAGDRLELPFWAKIWPASVILGYYLCSLPADKPLDMLELGAGVGLCGLVAAARGHKVLITDNHPDALLFARINILQNNLQERASVQTVDFTADHLSRSFDSILGAEILYQENIYPYLIRFLDKHLDTSLHGEIILSASNARKSPAFFNKAQENFQISHKTLECRDSSADDYEDQESHKITIYRMKARQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP11</accession>
    <name>D6SP11_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869809.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1846"/>
    <dbReference type="EnsemblBacteria" id="EFI34487">
        <property type="protein sequence ID" value="EFI34487"/>
        <property type="gene ID" value="Dthio_PD1846"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1892">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="253687at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01904">
        <property type="entry name" value="PEPcase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007566">
        <property type="entry name" value="PEP_COase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14010">
        <property type="entry name" value="PEPcase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006677">
        <property type="entry name" value="UCP006677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02751">
        <property type="entry name" value="PEPCase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="485" mass="54783" checksum="E6DA2183EBE51031" modified="2010-08-10" version="1">MKIPRCMSTQHPDNASAPFFSTNCVLAGEDEIREAYYAFSHLGCDEQMWDVEGKEIDTYVVKKLLSYYPEYFRKNVLGRDLRLTLRVPNPTVERAEAKILLETLESIPRSYDAARLVYGRDIVPIFEVILPMTTSARCIDRIYRYYTDHIIGRQSARFRDGDITIAEWIGKFSPSTIQVIPLFEDVPTMLKVSDIMYEYLADKDVKDQRVFLARSDTAMNYGLASAALANKLALKKFDEVAARTGVRLHPILGMGSAPFRGGLHPHSAERVGREYPSVVTFTIQSAFKFDYPVSEVQAACEHLKSRSIVPAADIDEEKALEVIERYSQAYRSRITELAPQICRMARYVPGRRARKLHVGQFGYSREIGQVSLPRAISFTCSMYSLGLPPELLAFESLSKNDLDFVLEIYPSFRDKIEYAMACTDFEGPLMSRSLRKALQASGFDHQASKEHLQIVRGLRNAVDACDSAQAGDLMLRAALLRGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP14</accession>
    <name>D6SP14_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869812.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1849"/>
    <dbReference type="EnsemblBacteria" id="EFI34490">
        <property type="protein sequence ID" value="EFI34490"/>
        <property type="gene ID" value="Dthio_PD1849"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1302834at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="315" mass="34185" checksum="C0283A6D70E4DCD3" modified="2010-08-10" version="1">MYFPVAEIQVAPWIPFLAGFAVAFVCSMGGVSGANLLLPFQVSILGFTTPAVSATNHLFNIVAIPSGVYRFIREGRMVWPLTITVIAGTVPGVIIGVFFRVQFLPDPTHFKVFAGLVLMYIGLVMARSLIKKPPPGADKASSEKRFQELVSRWHKKEKKSRDPLPRVMLHHFGLKRIEYSFYGEHISAPTMGIFTLSAIVGVVGGMYGIGGGAIIAPFFVAVFKLPVYTIAGACLMGTLITSVVAAVVFQAIAPFYPEMAVAPDWLLGILLGVGGMLGMYAGARTQKFIPANLIKLLLTFILIFTGGRYMLSFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP25</accession>
    <name>D6SP25_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiamineS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869823.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1860"/>
    <dbReference type="EnsemblBacteria" id="EFI34501">
        <property type="protein sequence ID" value="EFI34501"/>
        <property type="gene ID" value="Dthio_PD1860"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053248at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10492" checksum="548774CCC41EE304" modified="2010-08-10" version="1">MKKNKSNNAIYEPCFHAKSITIKLNLESILEKYAPDNPEYFQVSSDSTLADLLKYLGLSEDQVMLAFVNGKLANLKTRLSDRDSVSLCPYICGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP31</accession>
    <name>D6SP31_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tripartite ATP-independent periplasmic transporter DctQ component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869829.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1866"/>
    <dbReference type="EnsemblBacteria" id="EFI34507">
        <property type="protein sequence ID" value="EFI34507"/>
        <property type="gene ID" value="Dthio_PD1866"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1947990at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="180" mass="21085" checksum="CEB30EC4F7DB03AC" modified="2010-08-10" version="1">MAKKILHILDNLERYICVVLLSFFVIVLFFQIFLRAAFSIVLPWSEELSRFCFVWFVFFGASYAARLYAHNRVTMQFKLFRPAIGKFSQIFTDFIWIGFNVTMIHESIKVINNMQLFAFHSPALGWNMAYLYYIFPISFTLMSLRIIQVNYIMHVKKEAMGDVDKVDAEAMTKLAEKSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP82</accession>
    <name>D6SP82_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869878.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1930"/>
    <dbReference type="EnsemblBacteria" id="EFI34558">
        <property type="protein sequence ID" value="EFI34558"/>
        <property type="gene ID" value="Dthio_PD1930"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503404B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1745851at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15619" checksum="59D52124E79746B1" modified="2010-08-10" version="1">MNSKMPVQPFYNETGQLTGVWIPAEEWLKHQDDLESILLKSEKKSALPAEPLNEWTNFLMYWDFNYPVEKKVECKGCGALTSDWTQDDPKKFYLRSASLGGLVAFLCLGCQSRVTKKHFKDHILYECSEFTCKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP96</accession>
    <name>D6SP96_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="7">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="7">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869892.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1944"/>
    <dbReference type="EnsemblBacteria" id="EFI34572">
        <property type="protein sequence ID" value="EFI34572"/>
        <property type="gene ID" value="Dthio_PD1944"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="211" mass="22976" checksum="3C3FB72E7BE6E017" modified="2010-08-10" version="1">MTREKLTVVLATRNSGKVAELEEILAAVRPDLVVKGLDSYPGLADIPETGSTFEENALIKARAVAGHTGHLSVADDSGLVVPALDNEPGVYSARYAGEKASDLENNQKLLKRMNHLSGDSRQARFVCVLCACTPREETLVVHGEWPGIILDEPRGQGGFGYDPLFFDPQAGLSAAEMESGQKNSRSHRGRALQNLMQQWEEFMSRINKQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPC2</accession>
    <name>D6SPC2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869918.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1970"/>
    <dbReference type="EnsemblBacteria" id="EFI34598">
        <property type="protein sequence ID" value="EFI34598"/>
        <property type="gene ID" value="Dthio_PD1970"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="180"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="565" mass="64807" checksum="56AFC7E9E65657AB" modified="2010-08-10" version="1">MKIMLIYPRCLEPRSHELFSEDAGVTPIGLYYLGALLKSRGHQVEILNWYQLEQTDRDIRDMLLEKNPDLVGFSIVNANRLGATDTAALVKEILPGTVTVLGGIGATFLWEHLLKHYPQIDYVLLGEGEFSLLQLVSRLESRDHSNLEDLKGLAFRRGEETVCTGFPEPIQDLDQLPSPARYFTFQHLVSSRGCPSNCSFCGSPEFWGRKVRFHSPAYFVDMLQELYKKGVTFFFFSDDTFTLKPERVIEICRLIINRGLKISWFAISRVNCVDEEMLTWMRRAGCIQISYGIESGSPKIRKALNKKTGNQEIQTAFEQTVACGILARAYFIYGSPGETRETIRESMDLMERIKPLSAVFYILEMFPGTALYRELQQKSTLTDDFWLEKVEHIKYFETDPYMTPEMVLEFGRMLRTCYYQTLPRAAREIKLKDEPGLYPLHADFLSRLGMTFSHGDYSAIQEIPDKEKTAELLFEKSLAWYPNERAYLGLSIIRQKQGRHRQAYQCLGQGLKHFPGSENLAACQCISCMNLGLFQEALEHTDRFPDSSQMQQFRQACVQALAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPF9</accession>
    <name>D6SPF9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869955.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2007"/>
    <dbReference type="EnsemblBacteria" id="EFI34635">
        <property type="protein sequence ID" value="EFI34635"/>
        <property type="gene ID" value="Dthio_PD2007"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033FK9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="75" mass="8615" checksum="051CB30521F5B3B4" modified="2010-08-10" version="1">MFEIPVVEIFRASPWALLILIVPILPNLWAILHIFRCDFDTAQEKLAWLGLSVFIPFIGGLLYLFVGRRRGTKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPL4</accession>
    <name>D6SPL4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroK</name>
        <name evidence="3" type="ORF">Dthio_PD2062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870010.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2062"/>
    <dbReference type="EnsemblBacteria" id="EFI34690">
        <property type="protein sequence ID" value="EFI34690"/>
        <property type="gene ID" value="Dthio_PD2062"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="179" mass="20245" checksum="5238A06E61FEBCE9" modified="2010-08-10" version="1">MSQNKEKKILQQSTCLILIGMPGSGKSTLGRILCADRRCAWVDTDYLIQAWWGMPLQAVLDHLGLEGFLDAEAELVSSINLHQAVISTGGSVVYRPRAMQHLGSLGRIVYLRAGLEVISKRISDARDRGMAVQKGFSLEQVYRQRRPLYEKYAQLVLDTDKKSPEQCVEVLRQWQKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPX7</accession>
    <name>D6SPX7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870119.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2184"/>
    <dbReference type="EnsemblBacteria" id="EFI34803">
        <property type="protein sequence ID" value="EFI34803"/>
        <property type="gene ID" value="Dthio_PD2184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088263" evidence="1">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="24970" checksum="0FC94079549A55B2" modified="2010-08-10" version="1">MKKPTKKSTIPALVLGGFLAYATIGDKVNSEYQNTTQQNAQVETAKTDYKASALENLTNALAPAKAHAGTNYQRPDDATLKEWMNQPVEETLAGTNYTKVNDHNYQREVKQSDQPVMVLFYNAQGEASAGLTALTKTLHEKFPEIKLCAYKLSDRNTTPRNVYNHVTSEYPVEKTPSLLFYEEKDFGSGTEKGHAFNGGIKNFDLLTDTIESFYEPIKRNMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ31</accession>
    <name>D6SQ31_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/carnitine/betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870171.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34857">
        <property type="protein sequence ID" value="EFI34857"/>
        <property type="gene ID" value="Dthio_PD2248"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1217683at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018093">
        <property type="entry name" value="BCCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01303">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="663" mass="73898" checksum="B97D91A1CD978C7C" modified="2010-08-10" version="1">MEENTSPLSTEKSWIKINPAVFFSSALLTIIFVVLTISSPERAGEIFGSVQGWIAESVGWFYILSVATFLVFVIFLGVSSLGTIKLGPDHSEPDYTYISWFAMLFSAGMGIGLMFFGVAEPVMHYLSPPVGEGGTPEAARESMKITFFHWGLHAWAIYAVVAISLAYFAFRHNLPLTIRSAFYPLIGERIYGPIGHAVDTFAVLGTMFGVATSLGLGVTQINAGLEYLFGVPIDIWVQILLIAVITVIATISVVMGLDGGIKRISELNMILAVGLVIFVLIFGPTVFLMQTFTQNTGAYIADLAEMTFNLHAYDPTDWIGGWTLFYWGWWIAWSPFVGMFIARVSRGRTIRQFVVGVLMVPVGFTFIWMTFFGNTALHMIMIQGMTHLGDAVSEDATVALFRFFEHLPLSTIISFIATILVVTFFVTSSDSGSLVIDMLTSGGEENAPVWQRIFWATSEGVVAAVLLVAGGLGALQTASIASALPFTAIMLLMCLGLYKSVRMEVVKKVTLKHATTMPYSSQPGSWKKRLKTLVYQPTKKEVLNFIQQTVWPAMEEVAQEMEMRGIQTSIQEGEDGRVWLEVLHGEEIDFFYSVRPREYEPPAFTLRATSVNRPGQERKYYRAEVHLREGGQDYDIMNWTKDQIITDILDHYEKHLQFLDVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ32</accession>
    <name>D6SQ32_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870172.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2249"/>
    <dbReference type="EnsemblBacteria" id="EFI34858">
        <property type="protein sequence ID" value="EFI34858"/>
        <property type="gene ID" value="Dthio_PD2249"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1594866at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="404" mass="42419" checksum="8DE2F1CCCAF5D0FE" modified="2010-08-10" version="1">MDRMNILPDFIRQKPGLALFAMLAVAVSGFGQTFFVSVFGEEIRTSAGLSHTAYGSIYSLATLVSAAMLFKFGRLVDIWPLSRAVLLATAILALGCLLVGLKGGVLLLSVGFFCIRFGGQGLFGHMGMTTAARYFSAHRGKAVALAGSGFPLAEAVLPASAVFMAALWGWHVPWLASAGFLVLMVLPLLYYLTRDIPAPVQDLAGKEAKDSLRSHTREEVVRDRGFYMVLPAILASPFMVTALLFHQAAVASMQGWSMHVVGTAFTCYAAGHLGALLGTGPLVDRISAGKTLPLAVLPMAAGLMILAAFQGIWVAYVYLGLMGMTHGMTATAGGAVWAERYGLLHLGSIRAMAQSAVVLSTAAAPLLAGFLLDQGLGINILAAILAATTLTCGVLARFAPAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQE3</accession>
    <name>D6SQE3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870283.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2361"/>
    <dbReference type="EnsemblBacteria" id="EFI34969">
        <property type="protein sequence ID" value="EFI34969"/>
        <property type="gene ID" value="Dthio_PD2361"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8BU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="363806at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="514" mass="55338" checksum="64B99148ED0F25DE" modified="2010-08-10" version="1">MDTTHLVDQIANLQMLNQFFLSLFLLIPMVLVARTAVAGTRYSPILIIVVFGLTMGYVLVASGVSTPGLPQFSLIDLISRTTIVALTVSFFVGGQELRKILGGIKLEPDEMVTPSKEETILGTGRTQLIFIVRAFFLLVGIEALYRLIVGMGAGDLSRFYPIIAYLGLVGAVILIDHKAQVTNKRRYIKMGLVEIVAILGILIGSYTVAMWIEPLIALPQIFFSMVIAAGLGALMYRWQFGPTIRALLFAGIPVVLAANFMIGGSRIEEAFAITGMNAVLAYGFFGQMFWMFGGIALLMLFGKTDMARNLAPGMAGGLSHSGLTGACTAGDLGKTAAYRAPIMINVPFFGHIFVFSVLAMSAQKGSLMLLPSFIIVLAGVVLTVLSMRTMKNAGGEDAKEVKGLMQFSFGWQLCAVFGGFTLLSLASMSLDFTAMAVSSGISHFGLFAATQGGMFGEEASLMIPFIFSMPFLVHPLVFFMFGKAMEKDGSMPRKPVYIIALIGLLGIIYSMLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQG6</accession>
    <name>D6SQG6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M22 glycoprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870306.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2384"/>
    <dbReference type="EnsemblBacteria" id="EFI34992">
        <property type="protein sequence ID" value="EFI34992"/>
        <property type="gene ID" value="Dthio_PD2384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="239" mass="26188" checksum="20F849D399407CBB" modified="2010-08-10" version="1">MYLIINCAEGDLQIILGNSERLWFSSSLYVPGRAMKYMAPGIEWALGSLEMQTHELQGIACVSGPGSFTGVRMSLAHALGLACAHNIPLAGLSFMQALAMGPGPLIQGTLLVLVHSRREQVYAQAFSCPGLAVSSPAKNLHLSELKDLLSAYPDPVYLTGSGVRRNMDFFQHYRSAVLPRHWDVPAPHNLLRMSLEASWDTALPAPEYLRASEAEENLARIAAGRGLDLDQAREYLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQH1</accession>
    <name>D6SQH1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ORF">Dthio_PD2389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870311.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2389"/>
    <dbReference type="EnsemblBacteria" id="EFI34997">
        <property type="protein sequence ID" value="EFI34997"/>
        <property type="gene ID" value="Dthio_PD2389"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="184" mass="20909" checksum="061BD30F9D1BE1ED" modified="2010-08-10" version="1">MDQVLDDCREKMDKAIASLDKDLAKLRTGRASVGLVDGITVEYYGTMTPLNQLASISIPDSRTIAIQPWDRNVFSGIEKAIMKSDLGLNPVSDGKIIRINIPPLTEERRKDLVKMAKKYSEDAKVALRNVRREANDTLKKMKNDKDLTEDEMHKGHEEVQKITDSYVSKVDRILADKEKEIMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQI2</accession>
    <name>D6SQI2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870322.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2400"/>
    <dbReference type="EnsemblBacteria" id="EFI35008">
        <property type="protein sequence ID" value="EFI35008"/>
        <property type="gene ID" value="Dthio_PD2400"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2050366at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="10007" checksum="1DF20413C2FF1BFE" modified="2010-08-10" version="1">MKSITIHNLEDPLDTLIRQKAKSDGTSLNKTVKNLLAQALQVPSQGEQERRKDFLELFGVWSENDENEFRLRTRELDQVHQEDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQM0</accession>
    <name>D6SQM0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="10" type="ORF">Dthio_PD2440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870360.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2440"/>
    <dbReference type="EnsemblBacteria" id="EFI35046">
        <property type="protein sequence ID" value="EFI35046"/>
        <property type="gene ID" value="Dthio_PD2440"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="131"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="430" mass="47975" checksum="BC1E5B8AD1B4A4D5" modified="2010-08-10" version="1">MIKVYTHSLGCPKNMVDTENILSGLKEHYFAVDRPFESDVVLINTCAFIRPAVEESLETIFSAAQDVKGLSQRPLLVVTGCLVSRYGTGLGREIPEADMFVPIARQAELPGKILYRLGRKVEAEAPGVRHGPFKSFAYVKISEGCNNRCAFCTIPSIRGKLRSRPEHEVIQEAGHLIDQGAGELVLVSQDSTAYGRDLGCRRGLSSLAEKLAGLEGLLRLRIMYLYPSGLNDGLLARLAELGPPFVPYFDVPLQHANPELLKKMGRPFQQDPMEVIRRIRNYFPGAAIRTTLITGYPGEEERHFRELLEFVRQARVQHLGVFPFYPEEGTRAAGFPGQIPDEVKNERQRLIMQEQKRVSREYLKGFPGESLDILVDDPHPEWPGLYTGRAWFQAPEVDGLTYISGPGVGPGKMVRAEITASHDYDLEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQR4</accession>
    <name>D6SQR4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">Dthio_PD2484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2484"/>
    <dbReference type="EnsemblBacteria" id="EFI35090">
        <property type="protein sequence ID" value="EFI35090"/>
        <property type="gene ID" value="Dthio_PD2484"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="7"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="351"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="414" mass="45972" checksum="A6A9227DE4BD8AF9" modified="2010-08-10" version="1">MNMDEIRRVDPEIARSIDLEEKRQLNKLELIASENFTSLAVRQAMGTVLTHKYAEGYPGKRYYGGCEYVDMAEDLARDRARELFEAEYVNVQPHSGSQANMGVFFGMLKPGDTIMGMDLSHGGHLTHGCPANFSGKLYQTVFYGVEKETGYINYEQVEELALKHRPSMIIAGASAYPREIDFKRFREIADKVDAKLTVDMAHIAGIIAAGLHQSPVPHAHFTTTTTHKTLRGPRGGMILSRDEYARTLNSQIFPGIQGGPLMHVIAAKAIAFKEALAPEFKTYQQLVIDNARTMGRLLTDAGFTLVSRGTDNHILLVDLTNKDITGKDAEIALDTAGMTVNKNTVPFETRSPFVTSGIRIGSSALTTRGMRPEHMDQVVNWMIAALENASNQERLNQISKEVEKFAGDFPLFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQV4</accession>
    <name>D6SQV4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870444.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2524"/>
    <dbReference type="EnsemblBacteria" id="EFI35130">
        <property type="protein sequence ID" value="EFI35130"/>
        <property type="gene ID" value="Dthio_PD2524"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="174" mass="19861" checksum="BD9CA6D109229DF6" modified="2010-08-10" version="1">MNLREVFARDEIKKRVQDLGREISIFYGREKVLGVCVLKGAFVFFADLVRSLEIDMEIDFVRLSSYGDDTVTSGEVTVKNDLETDVWEKNVLVVEDIVDTGVSLYYFRQMLLSRGASSVRICALIDKHERRQLPVSVDFCGFRVQKGFLVGYGLDMAQKYRNLPGIYAIDPSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR02</accession>
    <name>D6SR02_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870492.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2576"/>
    <dbReference type="EnsemblBacteria" id="EFI35178">
        <property type="protein sequence ID" value="EFI35178"/>
        <property type="gene ID" value="Dthio_PD2576"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50334FI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923022at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="56" mass="6103" checksum="525BDDABA7CDE5B0" modified="2010-08-10" version="1">MPTKNPRINVVLESGLYSAVSDLAKQEGISKSMAIRDLVKEAMELREDVALTALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR69</accession>
    <name>D6SR69_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Archease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0511"/>
    <dbReference type="EnsemblBacteria" id="EFI33185">
        <property type="protein sequence ID" value="EFI33185"/>
        <property type="gene ID" value="Dthio_PD0511"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786857at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="6">
        <location>
            <begin position="91"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="25415" checksum="6A2210C2474F0F76" modified="2010-08-10" version="1">MLRHFRKSITLQVILSRSKITAIMFEINSNMNYILTKSQYSANNNTTRNTNKTPETAESGKFSSNISTRLHAELKTIQPGRTLCNMNNAYWKHLDHRADIGIQGVGPSLEQAFAQAGLALMAVMCDLELIHRKESRIINLEGHDPELLFFDFLNELIFLVSAEGFAYSWIEADINDGRLRARVLGESLDSLRHQPEVEVKGASFNGLKVWQDKNGKYIATCIVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRA7</accession>
    <name>D6SRA7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870581.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0549"/>
    <dbReference type="EnsemblBacteria" id="EFI33223">
        <property type="protein sequence ID" value="EFI33223"/>
        <property type="gene ID" value="Dthio_PD0549"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01068">
        <property type="entry name" value="globin_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039379">
        <property type="entry name" value="Protoglobin_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="169"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="385" mass="43963" checksum="A1C1A4DDFB087921" modified="2010-08-10" version="1">MRKQVPLERLLYFKEQIGFDAKTQELLKKHGHVIAEHKEDFAVYFEEFFRGVEETRPYLEVQEYPGQLQGIWKRWFESILTRDFDEHLVGWMWNSGITHVRINLDHRFVNLGYCLARRFCNQAISRSIAQEDMAEAMEAVEKALDLCLLIETEAFLANTFQCDSEVIRGIAHQIRNPITVIGGSIMRLKRSKEVTAGAAHETYDTILAESRRMEKMVRDVSSYNEVFHRQSEWSPVFLQEMLQQVLDECSNRYPVDNLDLQTGFAPMAKQVLGNPDEYRLMFRHLLANAFEAVDTENPVISVQTSLDPGTSMYVLVEIFNTGKLSGTDEMETLFTPFFSTRAMGTGLGLPISRVVAQKVKGNIMLYPVSKGGVACLASLPRGDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRN2</accession>
    <name>D6SRN2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870706.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0676"/>
    <dbReference type="EnsemblBacteria" id="EFI33348">
        <property type="protein sequence ID" value="EFI33348"/>
        <property type="gene ID" value="Dthio_PD0676"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503325D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017699at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="156" mass="17763" checksum="451E05CDEF3D2EE1" modified="2010-08-10" version="1">MKINSEYQNQINQSQESTQKKKPAEEFSRMLDQELSRSTGAGQGEKASNTARADMLHPAQLLGNSILTQQKQEPSFMNQMDDLLSKWENYAAEMNSPESSLKEIYGHLEHILEGVREMKDSKSFEDQRPELRSLVEELEVLATAEVVKINRGDYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRR0</accession>
    <name>D6SRR0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870734.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0706"/>
    <dbReference type="EnsemblBacteria" id="EFI33376">
        <property type="protein sequence ID" value="EFI33376"/>
        <property type="gene ID" value="Dthio_PD0706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10721" checksum="5029E52F4F5FEDB4" modified="2010-08-10" version="1">MIIRQYGIENKNPLRARNPATLEHNPRQAGDLPSYCSHALSRQGGRTSPGRSAAQRREFAHPSTITRLSYPYEIGRAGTLCISWGRRGRRNTPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRR4</accession>
    <name>D6SRR4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870738.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0711"/>
    <dbReference type="EnsemblBacteria" id="EFI33380">
        <property type="protein sequence ID" value="EFI33380"/>
        <property type="gene ID" value="Dthio_PD0711"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="153" mass="16549" checksum="5A2B75E336C45DB1" modified="2010-08-10" version="1">MESVAQRKGQGGFTLIELIAVLVILGILAAVAVPRFVDFQDEAEIASANAQGANITSASALNAAKAQVYQVSAFGTIEPNPVNVEDCSLGEIQKLEDDFMAEFDTEQFDIDTSTGFDEESVGKFLLHTVTDHEDPDDFETDTVDCWVIIADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRT5</accession>
    <name>D6SRT5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0732"/>
    <dbReference type="EnsemblBacteria" id="EFI33401">
        <property type="protein sequence ID" value="EFI33401"/>
        <property type="gene ID" value="Dthio_PD0732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="43" mass="4601" checksum="B26F77A2991C0A43" modified="2010-08-10" version="1">MNGKNSCGVKKKSGISAEYWSLITEHSGNYLKGGVCGIYVYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRT7</accession>
    <name>D6SRT7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional modulator of MazE/toxin, MazF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870760.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0734"/>
    <dbReference type="EnsemblBacteria" id="EFI33403">
        <property type="protein sequence ID" value="EFI33403"/>
        <property type="gene ID" value="Dthio_PD0734"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="108" mass="11832" checksum="CC51B4D66019EDEE" modified="2010-08-10" version="1">MKRGQLYRVYKAPGNDPKAFRVFVVVSRQVLLDSRFSTAICAPVYSACHGLSTQVPVGIENGLKHESSIHCDELVSIPKRMLSDFIGSLSPTQMNKLDQALAIALELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRW6</accession>
    <name>D6SRW6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870784.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0766"/>
    <dbReference type="EnsemblBacteria" id="EFI33432">
        <property type="protein sequence ID" value="EFI33432"/>
        <property type="gene ID" value="Dthio_PD0766"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040490at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="132" mass="14977" checksum="A6C3A3298C4C0077" modified="2010-08-10" version="1">MIALDTNALVRLGVEDDQAQAARARRLVSDAENRGEKVLLLSGVLLEMVWVLSKGYGFQRTDIAHLLDALLSSPTYEVENRTAVQVASLRYRMEGDFADLLFVEMARDRKARAFFSLDNRLINLFPDYARKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRX6</accession>
    <name>D6SRX6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870794.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0776"/>
    <dbReference type="EnsemblBacteria" id="EFI33442">
        <property type="protein sequence ID" value="EFI33442"/>
        <property type="gene ID" value="Dthio_PD0776"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="18666" checksum="5288E9C9F5502F61" modified="2010-08-10" version="1">MSTEPFTQEQISFLKEHMSQWLAEQSLGKPPMVYEIELRERMVRVEEELRNQRELIQYIIEQMDKRFEQVDKRFEQVDKRFEQVDKRFEEMRQDMNSRFEQVDKRFEQVDKRFEQFDQRFMALTKRMDRLLIWSFGTTVTVGGLIVAILKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS32</accession>
    <name>D6SS32_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0832"/>
    <dbReference type="EnsemblBacteria" id="EFI33498">
        <property type="protein sequence ID" value="EFI33498"/>
        <property type="gene ID" value="Dthio_PD0832"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1927281at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10936">
        <property type="entry name" value="CE4_DAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006837">
        <property type="entry name" value="Divergent_DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30105">
        <property type="entry name" value="PTHR30105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04748">
        <property type="entry name" value="Polysacc_deac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="440" mass="49901" checksum="F8F56751ECE652CA" modified="2010-08-10" version="1">MASSGKNKTGSQKKAAPRKNFPLGYFFWGAATVITLVSLLGILLLPPKKQSADTSSETLAQKKEQVTHTSSDPGKTLTATDRKFTYEEKVGTGFEQRVWEADMAILNVLDRMGKDQGHILRNRVDNRFFYGTPFNFQEMFIYTDDRQKQFIRQLEKVLDSFVANAEIKPQDPKRQKWAINISGHTTHVLHLGIQKPDRQKGSGSLVIIIDDLGECLEFARKLAELNFPVTYSILPYLHKTEEVAEFASKKDFEVMLHMPMEPDTYHRGVEPGPGALFVDMTPREIRRQLVHSLEQVPQATGMNNHMGSAFTRHYEGMQVVFEELEKRDMFFLDSVTTPDSVARRLARETGLDFMQRHVFLDNVRSIQAITYQLQKAEQLASRHGMAVAIGHPYPETLEALQQWSKNRDAKINMASVDELLLQQRIRAVSSSSDGHTASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS73</accession>
    <name>D6SS73_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870889.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0873"/>
    <dbReference type="EnsemblBacteria" id="EFI33539">
        <property type="protein sequence ID" value="EFI33539"/>
        <property type="gene ID" value="Dthio_PD0873"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="255" mass="28274" checksum="5E2AA22342BDFCA4" modified="2010-08-10" version="1">MTQNTTGPKHKGFYILPNLLTTAALFAGFLGILWAIEGRFELSALAILAACIFDGLDGKIARLTKSASDFGIQFDSLSDLVSFGVCPAVTIYLWQTHNFGQVGLVVPFLFMACGALRLARFNLQTKNLPKKFFVGLPIPAAACTLAALILFSTYLPEVILVHILPTFTLALAFVLSLLMISKVKYASFKELEMVRLHPFSSTVTAIMLFVLVASEPKLIIFIVFMTYIISGILYTYLYLPLRKPAHLREPRKEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSC1</accession>
    <name>D6SSC1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxybenzoate polyprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870937.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0922"/>
    <dbReference type="EnsemblBacteria" id="EFI33587">
        <property type="protein sequence ID" value="EFI33587"/>
        <property type="gene ID" value="Dthio_PD0922"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="297" mass="32923" checksum="1EBE06C1B0251405" modified="2010-08-10" version="1">MTSKTGSISAGVLQATLAWARMIRIEHSIFALPFAYMGLFWSAEGWPGWQVFIFLTLAMIMVRSFAMTHNRLTDLPLDALNPRTRDRALVTGEIQVRQAYYFLAASAVIFVLACAFLNLPVFLLAFFALAWSAVYSYTKRWTSICHFFLGSVLGLAPLAGWIAYTPELTLPAVFLFLGVLFWVGGFDILYSTQDMEFDRENGLKSIPARHGAATSFALAGFSHVNAALFFLLAGIAFAASWPYYLAWFVVAVVLFIEHRIISPDNLERLNVSFFTLNALVSVILLAGVLADVFLVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSI7</accession>
    <name>D6SSI7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871002.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0989"/>
    <dbReference type="EnsemblBacteria" id="EFI33653">
        <property type="protein sequence ID" value="EFI33653"/>
        <property type="gene ID" value="Dthio_PD0989"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="166"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="301" mass="33995" checksum="8F929AF1FC4DD8E5" modified="2010-08-10" version="1">MGHEPARILIVDDEKINLRVLADLLKDKYTIMLARSGEQALKLAHQEPRPDLILLDIAMPGMSGFEVIKKLKHDDATNHIPVIFITALDSREQEEKGLKLGAVDYITKPISPPIVKIRVRNYLDMQHKYKLLEQKANLDGLTEIPNRRCFEEVLAREWQRGKRNASPLSVAMLDIDCFKQYNDHYGHQTGDIALQRVARSIMDSLKRASDYAGRYGGEEFVILMPETPLESSLMVAERIRSDIESLAIPHALSSIAPHLTVSIGVASTRDYAESGPEEIIKRADQHMYTAKQSGRNRVFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSK2</accession>
    <name>D6SSK2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871017.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1004"/>
    <dbReference type="EnsemblBacteria" id="EFI33668">
        <property type="protein sequence ID" value="EFI33668"/>
        <property type="gene ID" value="Dthio_PD1004"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="6692" checksum="DBA5B5E04E41478F" modified="2010-08-10" version="1">MSYLVTVDVEKCNGDGECVDVCPVEVFELKDGKADPVNMEECLGCESCVEVCEEGAITVTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSM7</accession>
    <name>D6SSM7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871042.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1032"/>
    <dbReference type="EnsemblBacteria" id="EFI33693">
        <property type="protein sequence ID" value="EFI33693"/>
        <property type="gene ID" value="Dthio_PD1032"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50334IC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020942">
        <property type="entry name" value="Cyt_c_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02085">
        <property type="entry name" value="Cytochrom_CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrom_CIII" evidence="4">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="146" mass="16634" checksum="0D236F224BB6EC87" modified="2010-08-10" version="1">MFKKINYPWKIFAGGVLAVALMLAPHFISAQMPEYLIDNEDVYTSKKKPSVLFDHDLHMAVADCMDCHHHYKDGENVLEHHDLYEGAEGVMCRDCHAEPGTRFQEDHDPTEKDLEQAYHAQCITCHRDMAGEDATGPRTCMGCHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSQ4</accession>
    <name>D6SSQ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871069.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1059"/>
    <dbReference type="EnsemblBacteria" id="EFI33720">
        <property type="protein sequence ID" value="EFI33720"/>
        <property type="gene ID" value="Dthio_PD1059"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088190" evidence="3">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="41"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="420" mass="46094" checksum="BB1E12112A95DD15" modified="2010-08-10" version="1">MHPLIFKAALCLVALILTPACGLDREQEQNANEVPGVTEDTIRVGSSLALSGHASFLGTQTLQGAQAYIKHINEQGGVHGRQIELISYDDAYDPARCLANTQKLIVEDQVFSLFSYVGTPTTVKALPLIEEAEIPLLGIFTGASDFREPFNRNIINIRASYYQETEAAVTHFVEELGLDEIAVFYQYDAYGLDGLRGTELALKEYDLAPVATGSYTRGTLDIEDGLQSIMESGAEAVVMVGTYDACSRFIQTARERGFEPIFHNVSFVGAEEMARILGPAGDGVIITQVVPPPDSLVSQALLWGVQEFVDLYCRYFPEEDPNMVALEGFINAKVLVEGLKRAGSDLNRESFIQGIQTIQDFSLGIANTLNFGPKDHQGLTRVYFTVLKDGKLELLTDWDKFKQDIETKDKKSGPCPDSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSY3</accession>
    <name>D6SSY3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C20-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871148.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1138"/>
    <dbReference type="EnsemblBacteria" id="EFI33799">
        <property type="protein sequence ID" value="EFI33799"/>
        <property type="gene ID" value="Dthio_PD1138"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1209876at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="240" mass="26355" checksum="0F6F4235E331C4F4" modified="2010-08-10" version="1">MNNRQGKLYGIGVGPGDPELIPLKSINILKKVDVVFCASSSKNNHSLAVNIAREYLPKDTLIHRLPFPMTMDKEVASKAWSEHVDTILAELNQGKDAAFLTLGDPLTYSTFGYLMQCLQSNAPEIRIETVPGITSFQAAAAATNTTLVEGEESLLLLSGVQGGDKLREMSSRVDNVVFLKAYKNITDICEALDESGRMKTAVGVVRCGFPDQEVFQDVKELCSQEPKYWTLIISKPGQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSY4</accession>
    <name>D6SSY4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">Dthio_PD1139</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1139"/>
    <dbReference type="EnsemblBacteria" id="EFI33800">
        <property type="protein sequence ID" value="EFI33800"/>
        <property type="gene ID" value="Dthio_PD1139"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1996371at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFI33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="247" mass="25305" checksum="C73E443F7B42F8FB" modified="2010-08-10" version="1">MRFLQPFLAALQFLTIIPVGGQIPQTALGRAMPWFPVAGLVIGVGAGLAYTLTLLLGLPPMAASLVGVLVLSGLSGFLHLDGVADTADGFFSARSREKILDIMRDSHVGTMGVVGLFAVLGLKWAALTSMPPVAAWKALVLAPVLGRAAQVCSMALLPYARSTGGLASIFINSRRRSDIYWTLGIAGIASLLAGGAGVAALILGAVAAYLFSLWCLKKIGGITGDTVGAATEVVETAALCAICAIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6STA3</accession>
    <name>D6STA3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar assembly protein FliH/Type III secretion system HrpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871268.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1258"/>
    <dbReference type="EnsemblBacteria" id="EFI33919">
        <property type="protein sequence ID" value="EFI33919"/>
        <property type="gene ID" value="Dthio_PD1258"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1720989at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FliH" evidence="3">
        <location>
            <begin position="100"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="242" mass="27567" checksum="43A2C64042FC6CE7" modified="2010-08-10" version="1">MSLSDNTGKARMGRVIFGLQSRGLEEMDREAESAARTITPDQEQEFLGRVKEKAREKASEILNQAMQEASQMREDSVKQGYEEGLKNAKAEIEKQKKDLAQKFEKFLSQMHKEKKDICERHRENLVMVMQAGLEKVVGQKIDDDYARVMESLLREALEQMEQSRELTIKVHENDQELIKNLLAKAGDEHPELGKCKVRASRKIQKGGLVLESGQGMVDNTLDSRYSKVREVVDKISLKEDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6STA7</accession>
    <name>D6STA7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Flagellar basal-body rod protein FlgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5 6">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871272.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1262"/>
    <dbReference type="EnsemblBacteria" id="EFI33923">
        <property type="protein sequence ID" value="EFI33923"/>
        <property type="gene ID" value="Dthio_PD1262"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1870921at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006299">
        <property type="entry name" value="FlgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01395">
        <property type="entry name" value="FlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="146" mass="16270" checksum="6D819D09AF2D9797" modified="2010-08-10" version="1">MSFMKSLDIGASALSAERTHLNVISMNLANANTTRTPEGGPYERKSVLFRSTPLETPFGHAMQTELERELRGVKAQKVMTDQRPFKMVYDPAHPDADQEGYVKTPDINVVEEMANMLTAMRTYEANVSAVTNTKNMFNKALEIGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6STF1</accession>
    <name>D6STF1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="5">FBPase class 1</shortName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fbp</name>
        <name evidence="9" type="ORF">Dthio_PD1306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871316.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1306"/>
    <dbReference type="EnsemblBacteria" id="EFI33967">
        <property type="protein sequence ID" value="EFI33967"/>
        <property type="gene ID" value="Dthio_PD1306"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="945770at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBPase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="FBPase_C" evidence="8">
        <location>
            <begin position="199"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="336" mass="37530" checksum="EDFFBA529275D82E" modified="2010-08-10" version="1">MRQITVTEHLLVHQKASPMATGRFTRLLNELILAAKIISREVNKAGLVNVLGLTGDTNVQGEEVQKLDELANSILIYRMQRAGFLCAMASEENADLIEIPSKFAQGDYILLFDPLDGSSNIDVNVSIGTIFSIFRRTRENGPVYMEEVLQKGENQVAAGYFIYGSSTMMVYTTGSGVHGFTLDPSVGEFLLSHPNIKTPEQGKVYSVNESYWDYWDKPTQECVNAFKSSNNRRGKPYSLRYIGSLVSDFHRNLLSGGIFMYPKDNRDPKKTSGKLRLMCEANPLAYVVEQAGGAASDGQRRILEIDPHELHQRVPLFIGSKNDVEQAVSFYRDQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6STN0</accession>
    <name>D6STN0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ORF">Dthio_PD1385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871395.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1385"/>
    <dbReference type="EnsemblBacteria" id="EFI34046">
        <property type="protein sequence ID" value="EFI34046"/>
        <property type="gene ID" value="Dthio_PD1385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="478143at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="310"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="428" mass="47148" checksum="4D4E4AD0A5037CD7" modified="2010-08-10" version="1">MDWKEKLSFDQGHIWHPYTSLIDPLTVYPVESASGVRIRLTTGLELIDGMSSWWAVIHGYNHPELNKALAGQSQKTSHVMFGGLTHEPAIDLARELVRITPEGLDKVFFCDSGSVSVEVALKMALQYWQARGDTSRKRFLALRCGYHGDTFGAMSVCDPFNGMHSLYSGFLPENLFAPAPKSGFDGPCTPEDLQAVEEIMASHHQELAAFILEPVVQGAGGMRMYSPQYLARVRELCRKYQVLLIADEIATGFGRTGRLFACEHAGITPDIICLGKALTGGYMSMAATLCTTHIAETICRGDPGVFMHGPTFMANPLACSVSLASIRLLQESGWQEKTARIQEQMQRELITAGNIPGVRQARVLGAIGVLELDRQVPVGDIQQMFVQDGVWIRPFMNLIYIMPPYIIESGDLSRLTSAMLKAARHIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6STR6</accession>
    <name>D6STR6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1422"/>
    <dbReference type="EnsemblBacteria" id="EFI34082">
        <property type="protein sequence ID" value="EFI34082"/>
        <property type="gene ID" value="Dthio_PD1422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="46" mass="5084" checksum="4897E25FD99DB1CF" modified="2010-08-10" version="1">MKYCINKITVLQGCQVYFLQTGLVIKNWLYNPAGMTAVVLAGGFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU13</accession>
    <name>D6SU13_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0419"/>
    <dbReference type="EnsemblBacteria" id="EFI33104">
        <property type="protein sequence ID" value="EFI33104"/>
        <property type="gene ID" value="Dthio_PD0419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="42" mass="4601" checksum="2A7501584F8CA5FF" modified="2010-08-10" version="1">MKKPLIVRAEAEADLAEAFQWGKAAIEFTKLPGGLMGLELAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU25</accession>
    <name>D6SU25_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33116">
        <property type="protein sequence ID" value="EFI33116"/>
        <property type="gene ID" value="Dthio_PD0431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7703" checksum="3BF751AE08E54073" modified="2010-08-10" version="1">MNNTFACIDCEHCLPDSDGPTSMRFREKFCRVSYSRLCLCRIPGFSGAGLYKRTLEHLIWRIIYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU58</accession>
    <name>D6SU58_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871534.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0145"/>
    <dbReference type="EnsemblBacteria" id="EFI32838">
        <property type="protein sequence ID" value="EFI32838"/>
        <property type="gene ID" value="Dthio_PD0145"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="295" mass="32618" checksum="5AF15C3D518D6219" modified="2010-08-10" version="1">MSSKVKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPLSVLMLAGIKDILIISTPEDIAGYERLLRNGSDFGINLNYALQPSPDGLAQAFTIGSGFIGDDRVCLVLGDNIFYGHGFSPRLREAASKEKGATIFGYQVKDPSRFGVIEFDKYKRVISVEEKPAKPKSSYAATGLYFFDNDVVEIAENINPSPRGELEITSVIQAYLERGDLHMVQLGRGFAWLDTGTHESLLEASQFVETIEKRQGYKIACLEEIAWRNGWLSNTDLEKAGKALEKNGYGQYLLGLIVDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUF6</accession>
    <name>D6SUF6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871629.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32936">
        <property type="protein sequence ID" value="EFI32936"/>
        <property type="gene ID" value="Dthio_PD0250"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030C51">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1390639at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="328" mass="38410" checksum="5AB39CF82E6D0B49" modified="2010-08-10" version="1">MTLQENNFKSRICLGYTSYRLETLPFVQSKMQHYDCIVLEEPPTPGFDEMLKGEMQVHDYLMLTEFGFPGFAEKQCLLLQQMYGMGKTILQVEPFVEELIGLHEFFAAEGRPDQIRPETRAGMVYDCERRWSDKLMKFYQVSGANRDFSYLVKAVKNFARADAEKGRLRDKMRARALEDILPGYQSVYVEAGYIHFFLAALLFARKPPFSRLETFYSLQDFFRERLGRRQVLGPGDVLTLLYTWMPEYGGPRADLLAARSLIYNKIVRKDEILEETDRFPHSRNELKAVQLAGSLDYEECKDVYREIRGLETREAMESVEVWVERKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUI8</accession>
    <name>D6SUI8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871661.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0282"/>
    <dbReference type="EnsemblBacteria" id="EFI32968">
        <property type="protein sequence ID" value="EFI32968"/>
        <property type="gene ID" value="Dthio_PD0282"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034BEB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1972637at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="10035" checksum="0F096981DF535A2F" modified="2010-08-10" version="1">MPYIPEKRRQVFDPLLEELSREVHTQGELNYCIYKLSRLIAQRMGDSYDNLSMCSSAMEHAKLEWYRKVLAPYEDEKIREHGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUL1</accession>
    <name>D6SUL1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ORF">Dthio_PD0305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871684.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0305"/>
    <dbReference type="EnsemblBacteria" id="EFI32991">
        <property type="protein sequence ID" value="EFI32991"/>
        <property type="gene ID" value="Dthio_PD0305"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="13993" checksum="14A8065CE8717E68" modified="2010-08-10" version="1">MARIAGVDLPKRKKIGISLTYIYGIGRTTALKILDASGVDWTRKTEELTSDEVNVIRGELENNYKVEGDLRREKSADIKRLMDIGCYRGLRHRRSMPVRGQRTHTNARIRKGPKKTTIKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUM2</accession>
    <name>D6SUM2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rplX</name>
        <name evidence="4" type="ORF">Dthio_PD0316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871695.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0316"/>
    <dbReference type="EnsemblBacteria" id="EFI33002">
        <property type="protein sequence ID" value="EFI33002"/>
        <property type="gene ID" value="Dthio_PD0316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="3">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="11891" checksum="B3A673AAA38AA3E4" modified="2010-08-10" version="1">MNKTKIKQNDKVMIISGKDKTKIGKVLKIYHNKGKVLVEGLNKIKKHVKPNPYKQEQGGIKDAEAPVHISNVRVVCDACANPTKPAFRLTGDGEKVRFCKKCDENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUR5</accession>
    <name>D6SUR5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871738.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0359"/>
    <dbReference type="EnsemblBacteria" id="EFI33045">
        <property type="protein sequence ID" value="EFI33045"/>
        <property type="gene ID" value="Dthio_PD0359"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503379K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021952">
        <property type="entry name" value="DUF3568"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12092">
        <property type="entry name" value="DUF3568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088308" evidence="1">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="129" mass="14620" checksum="1567A2E65843F90B" modified="2010-08-10" version="1">MPAIKQKIHFLLILFLCLNLSGCLFALGGAAGGGAAIYYKGWLREKVARDMYTVHEATLKAMEVKNISLEEETEYTDRFRIQGKYMDGTNVWITVKHLTANSSQINIRVGVLGDESRSRALWDEARRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUT2</accession>
    <name>D6SUT2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871755.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0376"/>
    <dbReference type="EnsemblBacteria" id="EFI33062">
        <property type="protein sequence ID" value="EFI33062"/>
        <property type="gene ID" value="Dthio_PD0376"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SN5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1580372at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="15174" checksum="5CF845C968B1010A" modified="2010-08-10" version="1">MSNNKSVEEILTPEVLQQIFPPSRADDFFEALYGDPGEGTFDIQLMLAGNAGDRLDMEFRLKQRSGKCMACNLTYGLPQVFSRHPVIDLPGLMKEINALLPQGMQATDWKLGSTREVSSELHIIPWSLYLSGENKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUU1</accession>
    <name>D6SUU1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrwB_AAD_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871764.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0385"/>
    <dbReference type="EnsemblBacteria" id="EFI33071">
        <property type="protein sequence ID" value="EFI33071"/>
        <property type="gene ID" value="Dthio_PD0385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1207520at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019476">
        <property type="entry name" value="T4SS_TraD_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10412">
        <property type="entry name" value="TrwB_AAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwB_AAD_bind" evidence="1">
        <location>
            <begin position="327"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="493" mass="55529" checksum="8B9BFC8BB529C94A" modified="2010-08-10" version="1">MSQKKHDCRMGFVAHNNGQGQSKKKGAGNKAVANHVVSFDSGDSVSMDEAVHNQIVFGNTGCGKTSSVILPSLSNLMAKKMGGLVFDIKNNFTHHVRKLAHIHGRLKDVVEIGSFDSASPVNILAGLGDKEMEETLDSMIVTQFSESRNAEWIHKGARITKQCARVLRDLDRAMPGKGFAPSLALLSMMLNDEELSGHIWELWKEKVQDTGNRNAKLSQEVESDRFNILISKSIKNDKKDKDMEQQIAWRLAVPRKFLDGFSEGSLADNLSADRGDPLDLEELIFKQKKIVVLRFSPRYGSPGTRLARLVKEMFYNTVYSRFGEQDKKDTQEKVFNIMDEFQDIINLDENSSMDDFSWISKSREFGVINIAATQTMSSLYRSKVEYRVRAMLANFSTKIIMQTDDPATQEWVSRCFATNPLLSDLGPAETAVLRFKLPERRYEMYVDCLQKAHDSCKEMLDKAPAPPAAKASKKKGFNADKLYSRVTKHVMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUW2</accession>
    <name>D6SUW2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0407"/>
    <dbReference type="EnsemblBacteria" id="EFI33092">
        <property type="protein sequence ID" value="EFI33092"/>
        <property type="gene ID" value="Dthio_PD0407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="42" mass="4889" checksum="D454C7B1B1E257FC" modified="2010-08-10" version="1">MFEWDELKALANKTRHGISFAGTFAVFEDPNALTVEEYHHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJQ5</accession>
    <name>D6SJQ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869233.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3560"/>
    <dbReference type="EnsemblBacteria" id="EFI36108">
        <property type="protein sequence ID" value="EFI36108"/>
        <property type="gene ID" value="Dthio_PD3560"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014555">
        <property type="entry name" value="RecF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029347">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="30"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="371" mass="42428" checksum="0FDB815B5BF84F75" modified="2010-08-10" version="1">MSTTKKSIDYLTIKGFMSIQNMDRFPLGMLNVFIGSNGAGKSNLMTYFHMLGEMVEGRLQKWTRIKGSADRIMSFGVKETTRLESFIEFALNGYMFSLEPTVEGGFSFAKEKLFFQGPYYGPSWTDLGSGHSEAKLKEYYNTCKPGSTADYCYSSISSWKVFHFHDTSDTAGMKRLGALHDNDYLRPDASNLAAFLYRMAEEHPNIYQQIRKTIQLVIPFFDDFTFKPQTLPSEEKQIRLLWKQKDSDYAFWPSQLSDGSLRFICLATALLQPDPPSTIIIDEPELGLHPYAISLLGSMFRSASKRMQVIVSTQSVPLVNEFSINDLVVVERKQEATVFNRYNQEEFISWLEDYSIGELWEKNILGGRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJV0</accession>
    <name>D6SJV0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869278.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36153">
        <property type="protein sequence ID" value="EFI36153"/>
        <property type="gene ID" value="Dthio_PD3608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13530" checksum="052B61BA021EEFDE" modified="2010-08-10" version="1">MGIFSWIFGGGNVELVAKSLAKQHHALGNFNHVISAYYMDFSARQPGTRNYDKAMQAAEMIAKKEIKNYQDLGLLALYVDSTPNGYDLYFVRQSFSDEISKRLAQNGIDNYYIYNNALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJV1</accession>
    <name>D6SJV1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0051</name>
        <name evidence="2" type="ORF">Dthio_PD0063</name>
        <name evidence="3" type="ORF">Dthio_PD0465</name>
        <name evidence="4" type="ORF">Dthio_PD1499</name>
        <name evidence="5" type="ORF">Dthio_PD1877</name>
        <name evidence="6" type="ORF">Dthio_PD2082</name>
        <name evidence="7" type="ORF">Dthio_PD2980</name>
        <name evidence="8" type="ORF">Dthio_PD3535</name>
        <name evidence="9" type="ORF">Dthio_PD3610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868686.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0051"/>
    <dbReference type="EnsemblBacteria" id="EFI32761">
        <property type="protein sequence ID" value="EFI32761"/>
        <property type="gene ID" value="Dthio_PD0051"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32770">
        <property type="protein sequence ID" value="EFI32770"/>
        <property type="gene ID" value="Dthio_PD0063"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33144">
        <property type="protein sequence ID" value="EFI33144"/>
        <property type="gene ID" value="Dthio_PD0465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34156">
        <property type="protein sequence ID" value="EFI34156"/>
        <property type="gene ID" value="Dthio_PD1499"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34512">
        <property type="protein sequence ID" value="EFI34512"/>
        <property type="gene ID" value="Dthio_PD1877"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34709">
        <property type="protein sequence ID" value="EFI34709"/>
        <property type="gene ID" value="Dthio_PD2082"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35554">
        <property type="protein sequence ID" value="EFI35554"/>
        <property type="gene ID" value="Dthio_PD2980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36088">
        <property type="protein sequence ID" value="EFI36088"/>
        <property type="gene ID" value="Dthio_PD3535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36154">
        <property type="protein sequence ID" value="EFI36154"/>
        <property type="gene ID" value="Dthio_PD3610"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032W1G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887478at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="129" mass="14735" checksum="FAA7A0E0691B2FE3" modified="2010-08-10" version="1">MYQKYPIHPQRLRKVPRQFSWVDHRLVRDGHIERLSHAAAALYLFLVTVGDQQGLSYYSDPIVMQRLGMDEVTLQQARFNLIQADLIAWKKPLYQVLSIQVPPVNQARTAQAGPVHFSDVLKKLAGGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJX2</accession>
    <name>D6SJX2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3631"/>
    <dbReference type="EnsemblBacteria" id="EFI36175">
        <property type="protein sequence ID" value="EFI36175"/>
        <property type="gene ID" value="Dthio_PD3631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="53" mass="6049" checksum="C416CF15BE5DFABF" modified="2010-08-10" version="1">MNRVSLEFNRGFYRRPRGGYNMPNQGSINTKAPRVVVRLKGSKTTRPAQNQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJY7</accession>
    <name>D6SJY7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869312.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3646"/>
    <dbReference type="EnsemblBacteria" id="EFI36190">
        <property type="protein sequence ID" value="EFI36190"/>
        <property type="gene ID" value="Dthio_PD3646"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="100"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="207"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="414" mass="47983" checksum="2FFD277D00A04EBF" modified="2010-08-10" version="1">MAKWKYTKYPGVRYREHPTRKHGVQFDKYFSIRYTLDGKRHEEALGWASEGWSPQSAAEELARLKKAQRTGEGALTLAERREMENVRRAEDIKLKKEQEIASTTFNIIWEKYFLNSQHEKAYKSWDTERHLYKKWIQPFIGEVFFTKVTAFHLEKIKKEMRDASLSPRSIGYALSVVRQVFCYASDHGIFEGVDPVSLVKMPHYDNRRIRFLTHSEAEILLDVLCFSSQNTHDIALIALHCGPRAGEIFSLTWQDIDFSQGLVTFRDTKNKYVRHIPITKRVRKMLERRSDDRSSALVFPDRNGGRRKKVSKAFERTIKELGWNKGIDDPRQKVVFHTLRHTCASWLVMAGVPLYTVKEYLGHKQISQTERYAHLAPDSLKQATEALNKINSHKSEPGISGKAKTVVGLKKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJZ3</accession>
    <name>D6SJZ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3652"/>
    <dbReference type="EnsemblBacteria" id="EFI36196">
        <property type="protein sequence ID" value="EFI36196"/>
        <property type="gene ID" value="Dthio_PD3652"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032T5F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="234" mass="26673" checksum="7A7F32DC5781D690" modified="2010-08-10" version="1">MKITPEIDNASIVLLGRFNPAIFQPWWFAKNGIIGEQETFEAEIEIIHPELCKFQTEYFFVQAERNRFMVRSNSGPLELIKDFALKTFTDFLTYTPIGILGINRSVHFDAGSNEARIVLGKKLAPWEPWGEWARSFEGEDTEEQGGMLNLTMRENRSKKEGLKGYVRAKIQPSSELSGNSGVFMDINNHYDVVGIEEAVGCSKVMHVLEHQWSTAMGHAEFIINQIMKEIEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK15</accession>
    <name>D6SK15_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase with PAS/PAC sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869340.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3675"/>
    <dbReference type="EnsemblBacteria" id="EFI36218">
        <property type="protein sequence ID" value="EFI36218"/>
        <property type="gene ID" value="Dthio_PD3675"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="178"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="305" mass="34857" checksum="C974B845AD1FD917" modified="2010-08-10" version="1">MTRQNNNSIIFNSLFQALPFGVYIVDVQSHQLLFANRHLSEMVGGNVREGGICYREIFNFESPCMHCRIKELRSDGEEQSGDHLTFEFFNEYNDRWYQFHELMVPWTDGRLVKCTFAVDISELKAAQNSLAEAHARLAIKNEELETLYARDVLTGAYNRVKLDEIMDKELGRYERYGRLFSIILMDIDDFKDINDTLGHLAGDRVLYEMSNLLTANTRATDLLCRWGGEEFLLVCPETDSSGVRPLAENLRQMVAGHEFECGSRITISLGAATVRPEDTQDSMIARADKAMYLSKSQGKNVCNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK27</accession>
    <name>D6SK27_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3687"/>
    <dbReference type="EnsemblBacteria" id="EFI36230">
        <property type="protein sequence ID" value="EFI36230"/>
        <property type="gene ID" value="Dthio_PD3687"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930181at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="305" mass="34830" checksum="2ADEFC6BF113D710" modified="2010-08-10" version="1">MKDQCKIMKIDKNIFRWHSNGLTLIELLIVLVVMSLIMGGLVSTFISHSRISAAEAARMEVQQNMRVSVDRLKHVLRHAGFGCYASFAQGLVMSGDDPEGDTINISTFIDDDTKSNQFESDSVIIVYGFKVLGKVAEVLNDDEINLNKKPSPSITTQNDFKQYLSFFPGLAGNSFYEVYNVSDKDITFTSDLPISEEDLQHHDVEVYMVSPARIFIKDNNLQVQIFAYQRTAVDREQHWIVAENIEDISFQYYENGTWHDDDSTIGDMNNIRKIRFSLQGRSKEKVNGEYVRMESHGEVTLRNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK33</accession>
    <name>D6SK33_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869358.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36236">
        <property type="protein sequence ID" value="EFI36236"/>
        <property type="gene ID" value="Dthio_PD3693"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2092219at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8347" checksum="9DF8EE6D565C1BE9" modified="2010-08-10" version="1">MQNIDTILDQAMALPYETRLDLIRIIQKRTMEEERIRIAEECRTVEQEYATGSIKSGSVQDLMHYLENDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK48</accession>
    <name>D6SK48_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36251">
        <property type="protein sequence ID" value="EFI36251"/>
        <property type="gene ID" value="Dthio_PD3710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="36" mass="4201" checksum="D1711AF283B1A679" modified="2010-08-10" version="1">MTLVSLAAKRDDEDLYTLRQARNVNIIFTHRVKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKB1</accession>
    <name>D6SKB1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869433.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3778"/>
    <dbReference type="EnsemblBacteria" id="EFI36314">
        <property type="protein sequence ID" value="EFI36314"/>
        <property type="gene ID" value="Dthio_PD3778"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="195" mass="22472" checksum="0090574AC2CB6F99" modified="2010-08-10" version="1">MAKNKKKKILEAAADLFASHGFDNTTTMQIAKGASVTEPLLYYHFKGKEDIFSTIIEEVFQKYSELLSELPKDTETEFEKIANLIRLHSRIAEDHPQSARLFLSNCPSKLMHEQHTCRDILEKQQQMVSSYIQDCLEAGNAKKEFDAHPVEHMTLILLCLFNEFMRMKTTSEKRYQPDMQATIELCRRALVGSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKC6</accession>
    <name>D6SKC6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869448.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3795"/>
    <dbReference type="EnsemblBacteria" id="EFI36329">
        <property type="protein sequence ID" value="EFI36329"/>
        <property type="gene ID" value="Dthio_PD3795"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="121" mass="13554" checksum="553213EC832F937B" modified="2010-08-10" version="1">MVINQGDIFWIDLTEPSGSKPGYRHPHIIIQNNLFNRSRINTVTVCPLTSNLKRAAVPGNVLLKKGEANLPKKSVVNISQIFTVNKSDLSEKIGSLKFGRFQEVLQGIKLITEPREVDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKG4</accession>
    <name>D6SKG4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNP-1 like RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869483.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3838"/>
    <dbReference type="EnsemblBacteria" id="EFI36367">
        <property type="protein sequence ID" value="EFI36367"/>
        <property type="gene ID" value="Dthio_PD3838"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029304at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9479" checksum="6F363B0EFC4C0082" modified="2010-08-10" version="1">MTNLYVGNLSWNTTETQLRDSFAEFGEVSSAKIIEDRETGRSRGFGFVEMENGADEAVEKLNGKDFDGRTIKVNVAKPKRESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKG6</accession>
    <name>D6SKG6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Auxin Efflux Carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869485.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3840"/>
    <dbReference type="EnsemblBacteria" id="EFI36369">
        <property type="protein sequence ID" value="EFI36369"/>
        <property type="gene ID" value="Dthio_PD3840"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="302" mass="32833" checksum="8E218B4F424C636C" modified="2010-08-10" version="1">MSYYILPVFFVIILGYVLKNCLFKENNFWGVVQKSTYYIFLPALLFENISQIQAMHYSSLLMMSALLLSVLIISLFLFAIKPYINTNGHGFSSAFQGSLRQNVYIGMMGASTMLGDEGLMMSSIAMLGLVPLLNFLSVPTVIICSNTKFSKTRSIYLAILKNPLIVASVAGLIISQHPVVLPDISLQIFSILGQAALPLGLLAVGASLQLRSVNLEQFKLIALSSTVKLLVYPFLTAMICYVLGVSGSELVVAILFASLPTAAGSFILAKELGGDHLAMSSIITFQTIFSFITIPFMLAILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL23</accession>
    <name>D6SL23_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35384">
        <property type="protein sequence ID" value="EFI35384"/>
        <property type="gene ID" value="Dthio_PD2800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="110" mass="11776" checksum="B4232923684E79FC" modified="2010-08-10" version="1">MQHQFKHGACLDFFAGKVQFLTLCSVKCKAPLGSQDSGRGAAHGTDNVAPVFVVFMLLPLSGSVSESGSKIPGSVPLDFASGFDSDCEPDTDPDTDYQRKHGHFGIMEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL31</accession>
    <name>D6SL31_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">Dthio_PD2808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868524.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2808"/>
    <dbReference type="MEROPS" id="M41.001"/>
    <dbReference type="EnsemblBacteria" id="EFI35392">
        <property type="protein sequence ID" value="EFI35392"/>
        <property type="gene ID" value="Dthio_PD2808"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="185"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="644" mass="71176" checksum="ECA28DAED67D9B76" modified="2010-08-10" version="1">MNTFSKNLLLWATISIVLIMLFNMFNQPQEQQEKLTYTELLNKIEQGEVMAVKIKGQEVSGVTFDEQRFISFHPEDPNFVDMLLRNNVQVEAEPEEERSMLMTVFISWFPILLLIAVWIFFMRQMQGGGGKAMSFGKSKAKLVAQEDSKVTFSDVAGVDEAKDELTEVVDFLSDPKKFTRLGGRIPKGVLLVGSPGTGKTLLARAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFVQGKKNAPCLIFIDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFESNEGVILIAATNRPDVLDPALLRPGRFDRQVVVPNPDLAGRKHILEVHSRRTPLATGVDMEVIARGTPGFSGADLENLVNEAALQAAKKSKEQVGMEDFEEAKDKVLMGKERRSIILSDEEKKTTAYHEAGHTLVAKLLPGTDPIHKVSIIPRGRALGVTMQLPEDERHNYSKTYLENNLSVLLGGRVAEELVFNQMTTGAGNDIERASKMARKMVCEWGMSETLGPLSFGGKGDEVFLGREFVQHKEYSEDTAKLIDAEVKRIVQDGYDRAKMLLKENMDSLHRISEALLDRETISGKEVDKLMQGEDLPPIEEELKKDQSKSGDSKESDDGGDKGDSERDSAADQDEDSGFKIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL62</accession>
    <name>D6SL62_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868555.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2843"/>
    <dbReference type="EnsemblBacteria" id="EFI35423">
        <property type="protein sequence ID" value="EFI35423"/>
        <property type="gene ID" value="Dthio_PD2843"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031FBP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8626" checksum="5EA2802253B29BD9" modified="2010-08-10" version="1">MANITLKVEDELLKKARSLAGRKNTSLNAVVRKMLRDFVNSDAKVQEAIDSLDDFYRKCDAAIGTGSWTRDELHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL77</accession>
    <name>D6SL77_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868570.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35438">
        <property type="protein sequence ID" value="EFI35438"/>
        <property type="gene ID" value="Dthio_PD2858"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1992513at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="111" mass="13019" checksum="F9AA77926715C6D8" modified="2010-08-10" version="1">MKSVITVFWATLSMVLFSFSVSLAHCIWTEVPFTVEPDQEFNVRAYYAHPDYLLEERDKTNLSLVVLKPGQEMEEIVLFENPNHYDNDIILTNPGQHIFVLERDPNRYMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLC5</accession>
    <name>D6SLC5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868618.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2909"/>
    <dbReference type="EnsemblBacteria" id="EFI35486">
        <property type="protein sequence ID" value="EFI35486"/>
        <property type="gene ID" value="Dthio_PD2909"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032X8P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016243at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="132" mass="14528" checksum="9578B1B5591AB6FE" modified="2010-08-10" version="1">MSVKRLVMNKRLCMFILAFYSLVAFIPSIGEASLIESRLSTGEKMSERSEKIESIRKALEHEVVAQRLADYGLSQEEVMARMEGLDDEQLHQLATLSDEVGGGGVGLAIGVLLVVLLVVVILQISDKRIVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLK9</accession>
    <name>D6SLK9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">INB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868702.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2996"/>
    <dbReference type="EnsemblBacteria" id="EFI35570">
        <property type="protein sequence ID" value="EFI35570"/>
        <property type="gene ID" value="Dthio_PD2996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INB" evidence="3">
        <location>
            <begin position="773"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1921" mass="210846" checksum="EC434F9E4C329464" modified="2010-08-10" version="1">MSSDGTNYPGGTRDEARLIELTQEKSFAFHLSPQEYHYYQFDADQSAMEIHVTKGDVSVELQDEDGNTLASGDQGIRYGGLEEGRSYYIQVENEAGSWWWQDKTEYHLDITPLDFLPADDPDEAVELVLEEDREATLQPGDGSHYYQFELDEARAIDIEATGSVSLTLKDSQGEKLQEGEDFLQKDSLDAGEYKVVVEHQDSRWWWQDKTEYSLGLNTAEAGRPDEPGQDPDAARVIDIWEAVSEEGKSFQEEVPAGEDHFYKFELDVDAEVGLEATGNVSLDLLREGDEGDSLETVKEDKDSIQTELDPGEYYVRVSNETGEWWWQEDAEYELDFEVSPDGYEVSTYEELQKALEDSDDLLGPEGELIIHVQADIGGEGFESHGPLSYDLDHDLTITGDVTLDAEDHSRIFELDAPDHNITIDDLTLSGGNHEDGLPGGAIWAHVSSLDVEESVFVDNTGNIAVRGNDEVNTFMGTDGDDHFVVVGDLRGASKTNEPEHTALLGTQLTDLVGYNFDEDAGGSAQVINGAGGTNTLHVYGVADISNFELENVNFLEINSDVTADASDIEGMDFIKGDGGSTLRVVSGEAVEIDLSEFSGVSRLHVAEGVSASISSLGGVRSLSGTGTIAAREGALDLREGMVVERGLGLKDADGADSDRSGVREVDEVRDSDRDADVIEGGPGDDYLVGNTSDQLFLPGGGSNVIEGGGGQNIYRLEEGSDNTIHASPSDDILDLSLISEGVALDLREGGTGEDEAVGITVVVGGEAAGRGALDVHLSQDLSGSFGTDVATLRSHVDPDGDDPSLMEQLREVQPNTNFGLSGFIDKPLQDVFDTTLGGGGGDTPEYPFEEKLDMTSNADRFVEAVFDDELMEVRWGGDAPESQLSALQQIGLRGNPYDDTYENSIGFRAGATKVAIIATDVDFHEGPIMNETLEQEIPPNDGTTTLRRWKGDEDNPPDVIGPPGTGEDFPTRTQVKEALDGADIYPVILLQNYDWYRDDYEELLDYIGRGSIVPLAGRTDDVTAAILEAIGTIDQPAIQTVVGTQGDDQITGNRLNNVIWGYGGENTIDGGGGTNIIIGSGNADTLELPGTREDHEISWVSVEDAPIDIPQFDPDNWEVDLPPILDAEKENLGWLKIESDPVSLLPIGDLAGFDVSDLSADNIIDALSASATLIENISFEDDDEWTLTDLVEDTEGLAEAIVEGLDTQPIELVSLNHNVWDRLEVVYDIDDSIIDDVENVNLELWTYDGEQVIEVSLVSRVSEDESLEDLIRDGSFSVHDDDLGFYDEDGEWSDPHSLHGAYEVRLQLSFEDEDNLVFSVAKDNSDDSYELVNRTDEDGLELDEGGGDRAYVNVNEPKVLAFYTSIFGEFADAGHDEKPYETATVTIFDKDEEALDPDDGDSVLATFDWERDTAGNYLTVSAEELSDALGTHVDLGRYQYHLEVENSAGHGGATRVKEGEFWGLPELVWDIASSGDGDLEGQNAGLNYNLASPANTLYSNIPEDFWSNFGLEDRDSFEEILLDVGLTLASAIYQNGITHSALVHKITSGYFHDQGYYDWYVSRGYEGRYHIANDFRGAAGDEIFSPVNGDVIHTRDWTISNNNISYILIEEEDGKVWQFMHINWDEDLSVSENVSVGDPLGTISGHDGTMTPHLHLSVFLKNKMPEGALESNGFRYEGGQSSSYISDTISFNQSPLQAWYDTANFFINENGELERDLSIDSYTISELTLTTDQLSTLGITIRDPELDLEGWSDFLSLSLNNSDGDTESVDVSLQLETAMIVDDGGLDVYEWRDGGFVVSEDVNFQQGEVTDPVTRGDHYDSDNLVKLDREDVNYYLSRDDYEARLTLDFDQDVVLYTEDNTNIPEGIRIDNQSDLNALFMITRDDDHRPDQEDGVTIQDDYDEVTVDVTGVHYDDGLVMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLL8</accession>
    <name>D6SLL8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SapC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868708.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3005"/>
    <dbReference type="EnsemblBacteria" id="EFI35579">
        <property type="protein sequence ID" value="EFI35579"/>
        <property type="gene ID" value="Dthio_PD3005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1512520at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010836">
        <property type="entry name" value="SapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07277">
        <property type="entry name" value="SapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="229" mass="26197" checksum="6503791D76D615C1" modified="2010-08-10" version="1">MKPITPKTHADKRWQKPSSYSFARQSALVPLALLDLSRAVMEMPIVLFRQKGEYHLAALLGQKKNKNLFVDSDGKWQGQYVPMLLKCYPFRMVQDKEGRYILCVDEESGLVGDKGSKFIDDEGKPTQKVQAIGKFLQQAEQSRMAAVKACKVLDDCDLIKADPKMPGLYGIDKKKLGQLPEESLPDLHKSWALFLAHCQMISQQHLKKLERMSEQDVDFDEIDWEKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLT2</accession>
    <name>D6SLT2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868772.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3072"/>
    <dbReference type="EnsemblBacteria" id="EFI35643">
        <property type="protein sequence ID" value="EFI35643"/>
        <property type="gene ID" value="Dthio_PD3072"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="237" mass="26400" checksum="11198E18E8130491" modified="2010-08-10" version="1">MAEQNGSTRKGPGRGAILKILALLLFIVAAVYSVQFTQLREYFTQETLVAFLEDIGWWAPAVFSLLYAIGVCLFVPGTLLAGVGAALFGPYVGFVFVWIGAMLGASTAFFIGRTLGREFAASLIGDRLKKYDEAIERNGFATVLYLRLIYFPFTPMNFGMGLTRVRFWDYFFGTAFGIVVGTFIFTFFIGTLRDVWLSGEWSGLLSWQVFLSVVLFAFSLYLPRLVKKIKGENGAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLT8</accession>
    <name>D6SLT8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">Dthio_PD3078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868778.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3078"/>
    <dbReference type="EnsemblBacteria" id="EFI35649">
        <property type="protein sequence ID" value="EFI35649"/>
        <property type="gene ID" value="Dthio_PD3078"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="122"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="260" mass="28262" checksum="A3DD5F0F0AAFABC4" modified="2010-08-10" version="1">MQTQVIVMGAKGRMGSTISKLAMEDSQLDLVGVVEREDNLDGLDSLSCKVDSDLSRILDSFPGAVVIDFTVPEASMETVEKCSSAGAAAVIGTTGFTAEQSQKLESLAASTRLFWAPNMSVGINVLIQILPELLKSLGEKYDLEIMEIHHKFKKDAPSGTAVKLAQILAETKGLDMDRHGVYARHGIIGERQKDEVGVQTLRGGDVVGEHTFYFLGPGERVEVTHRAHSRETFAQGALRAARWLVEQKPGKLYSMADIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM11</accession>
    <name>D6SM11_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recO</name>
        <name evidence="9" type="ORF">Dthio_PD3151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868851.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3151"/>
    <dbReference type="EnsemblBacteria" id="EFI35722">
        <property type="protein sequence ID" value="EFI35722"/>
        <property type="gene ID" value="Dthio_PD3151"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="237" mass="26932" checksum="E2F2F5666884DCA1" modified="2010-08-10" version="1">MSFSEKVLVLRTGRFKEHDLWVRFLSPTRGVQTGFAFGGCRSRRRFCGCLDSLNLVLFTIGYSSGKRYLTLQEGTLVSGFQELKNQRDKLGMAVNCLRFVQKICPEGDDSSRIYPLILEVLEVMENHPDIPIFFPLLFKARAAFIHGYEPVPAECAVCGLGAENMHLGFFSFSDGRVFCPGCIRDQKGTIKTGRESLLFLDRLRTSGPGQWLDWNPEPEVLQDCFRVIDAYVQYHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM85</accession>
    <name>D6SM85_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="13">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="13"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868925.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3231"/>
    <dbReference type="EnsemblBacteria" id="EFI35796">
        <property type="protein sequence ID" value="EFI35796"/>
        <property type="gene ID" value="Dthio_PD3231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="593" mass="64417" checksum="4B61EFED40BADB05" modified="2010-08-10" version="1">MDNNSVVIKVCSGTGSISAGGALVLDAFRKLVLSSDLEASFQNRCRADKVGCRGFCARDVLVDVVVDGEKTTYERVKSDMVPRIFEEHILGGSPVQEWTADELHQSFQDNQKKVVLAHCGEIDPEDLDAYLNVKGYQAARNAFNNMHPVEIIEKIKRSKLRGRGGAGFSTGHKWEFAYKVDDQEKYVVCNGNESDPGAFADRCIMEGDPHAVIEGMMICARAIGAGKGYIYIRDGYSLAVKRLRLALKQCYERGLLGKNIFESGHDLDIKLYPAPGAFICGEATALVQSIEGKRAMPTPRMTRTSENGIRGKPTVINNAETLANVPKILRNGASWFAGLGTDTSGGTKVFSLTGKVKSNGLVEVPMGATLRDVVYKVGGGIDQDRAFKGIQLGGPTGGCVPGSCLDSRVDYESLALAGTIMGSGGMVVLDETNCIVDTAKFFLDITQAESCGKCTPCRIGMRRMYEILERITIGNGRDGDVELLEDLGSHIRATSLCGFGMTAPNPVLSTVRYFRDEYNIHIRDRKCPALVCKSLLTFSCIEETCTGCGMCKRVCPADAIRGTRKKPHFIDQELCVKCGSCFDSCKFGAILKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM93</accession>
    <name>D6SM93_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CO-methylating acetyl-CoA synthase</fullName>
            <ecNumber evidence="1">2.3.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.169" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868933.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3239"/>
    <dbReference type="EnsemblBacteria" id="EFI35804">
        <property type="protein sequence ID" value="EFI35804"/>
        <property type="gene ID" value="Dthio_PD3239"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66502at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018492">
        <property type="term" value="F:carbon-monoxide dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043884">
        <property type="term" value="F:CO-methylating acetyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045822">
        <property type="entry name" value="ACS_CODH_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004461">
        <property type="entry name" value="CO_DH/Ac-CoA_synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038571">
        <property type="entry name" value="CO_DH/Ac-CoA_synth_bsu_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041350">
        <property type="entry name" value="CODH_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42281">
        <property type="entry name" value="PTHR42281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19436">
        <property type="entry name" value="ACS_CODH_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03598">
        <property type="entry name" value="CdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18537">
        <property type="entry name" value="CODH_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00316">
        <property type="entry name" value="cdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CODH_A_N" evidence="7">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="ACS_CODH_B_C" evidence="8">
        <location>
            <begin position="483"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="726" mass="79459" checksum="6EF4302811D7D51C" modified="2010-08-10" version="1">MSKIIASAAIRGAHAIVSRAEERLKEAIDAKGPDEPVAFPNTGYYLPVIYALSGHKVEKLSDMEKPLALARDMLGEIPTDSLWLPYLGQTLDSGISTLFAQEIMQGVRYVIGPSPVHGIYLGAADDAIMRQRGVEFVDGSAPGFAAVVGAAPDNETAVKIARELQQKSLYVFMAGSTNGVCFADQLAEEGVQLGWDTRLVPFDNEVHGQVYSLGFAARAAMSFGGVKPGDFKNILKYNKQRIFAFVIALGEVDDEKYATAAGAISYGFPTIADTDIPEILPTGVCTYEHVVSSIPHDKIVQKAIEVRGLKVTVTEIPIPLSYGPAFEGERVRKDDLFAECGGRKSTCCELLRMREMEEVEDGRIEVVGPDIDELEPVGVLPLAIVVDVAGRKMQKDFEPILERQFHHLINSAEGIMHMGQRDISWIRISRQAREKGFKLSHIGDILHAKLLSDFPSIADKVQVTLYTEEDKVNEILQEARTLYNERDERLAGLKDESVDTFYSCSLCQSFAPNHVCVITPERLGLCGAYNWLDGQASYEIDPSGPNKPVAKGEVIDQHKGEWQGVNEFISQASKGNLERLKAYSILEDPMTSCGCFECIVALLPAANGVMVVDRDFSGMTPSGMTFSTLAGMVGGGIQTPGFLGVGKFYLGSDKFISAEGGFKRLVWMPSHLKERLRNMLQAQAEKVGEPDMLDKIADETVATTEMEVLEYLEKVGHPALGMDPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMA5</accession>
    <name>D6SMA5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3251"/>
    <dbReference type="EnsemblBacteria" id="EFI35816">
        <property type="protein sequence ID" value="EFI35816"/>
        <property type="gene ID" value="Dthio_PD3251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="30" mass="3190" checksum="EAD14DEE63CD7D5D" modified="2010-08-10" version="1">MESILVLILVVVAMIFLLKVVLPSCGFQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMP9</accession>
    <name>D6SMP9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869088.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3402"/>
    <dbReference type="EnsemblBacteria" id="EFI35960">
        <property type="protein sequence ID" value="EFI35960"/>
        <property type="gene ID" value="Dthio_PD3402"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="261" mass="29315" checksum="20C2CB356A636082" modified="2010-08-10" version="1">MAISNSFGKNSSSRNNPWEVLEQNGVAFDQLSAADKNEIVRAYGQKIRITAARLKHKLPAHVDVNDLISAGSLGLIEALGNFDPTQGIKLETFADNRIKGAMLDELRRMDWFSRGLRKKVKKLEQSMREFEQNTGHSPSHSELKEITGYSREEVEEGLLALQNQICLSLEAIQENFSATGTQDSDEPQLSVVFHDLVDKVAAIIEKLSNKEQLVLSLYYTEELTMKEVAQVLDVTEGRVSQLHSQAIKKVKDNFAQEHDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMW8</accession>
    <name>D6SMW8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3471"/>
    <dbReference type="EnsemblBacteria" id="EFI36029">
        <property type="protein sequence ID" value="EFI36029"/>
        <property type="gene ID" value="Dthio_PD3471"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1838027at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="16536" checksum="F2EE6A7998AA6A57" modified="2010-08-10" version="1">MAGHHLFHVNHDHTTDSDVSLKDETVWLTQAQMVELFQRDNRTISEHVRNVFKEGELSEQAVVRKSRTTAVDGKICQTNYYNLDVVISVGYRVKSLRGTQFRIWATQILKEHLVRGYTLNQRRLAEKGIEELKQALAIGGQYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN46</accession>
    <name>D6SN46_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polymorphic outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1520"/>
    <dbReference type="EnsemblBacteria" id="EFI34172">
        <property type="protein sequence ID" value="EFI34172"/>
        <property type="gene ID" value="Dthio_PD1520"/>
    </dbReference>
    <dbReference type="OrthoDB" id="324825at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088119" evidence="1">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="21318" checksum="F289ED5AACE194F3" modified="2010-08-10" version="1">MKRWMISILLLSLVGCTTAHYRVHDKEELRYALEDPDNLAGKELVIRIASSISDIGRPFVYDGSSDLRLTGAPAELTSHGRNHLLRSDSKAKITLENLTFSGGRTGVGSERGGAVYHLGDLVINDCKFLDNAAEFGGAVYAGGRVDIQRSRFEHNQARWRGGAVYSEDKITTTDSIYQDNSEPVLYVRDKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN94</accession>
    <name>D6SN94_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type multidrug transport system ATPase and permease components-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869548.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1571"/>
    <dbReference type="EnsemblBacteria" id="EFI34220">
        <property type="protein sequence ID" value="EFI34220"/>
        <property type="gene ID" value="Dthio_PD1571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="601" mass="67320" checksum="3118B2AA74C578AB" modified="2010-08-10" version="1">MPLKTLGSWLVGRRDLPAQAKRYAQTVIWLYRSVFHFRPYTAALAIATNVSGTLLKGASLTLLVYFASMLESDTPFTFNQIDFALQPREPSGFALMVLLIGTLLLSGGIVVFLANRINIKLAVEFALNLSQQVLTLPAGRPSRNINPIAGAYPKEIYARSRGVIVIARSIRPLLQLFQPLLLMIICLAALMYIDPFLTAVIAVLALPSLLIQYLINYTAAQNQKLLGKAQKRMQRGICDILESLSLAPRVSRSEEEALARAYSSEVIREYPNRFITRVMAQPKSQMVSDMLIAVMAMIIVLYLGISALAGQISWALVVGYIIFARVGMTSLRGLLGTITGFARHYPRARKMYELLSSKPMETRLNQDVLKITRSARNTPGDLKSIDFKRGDTLGVLSPVPFTRYNIYAWGDALGWPKGVDRNKILGAIACIPDATKSRPGGSLRELLGCDEYISTNEIQRILEGIVTAPLKSAVADIDFDSPLDEHTWNKLPPVLRSHLLLEQGIKSGKDIFLVEYQVVQKAEDEYLRLWWKRASSRFVLIRYNMQENFGHCGEKGLLAMRTDRARAVMSLEWARMNHEKLSAWIANARVIEEEDEEDPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNC1</accession>
    <name>D6SNC1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869575.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1598"/>
    <dbReference type="EnsemblBacteria" id="EFI34247">
        <property type="protein sequence ID" value="EFI34247"/>
        <property type="gene ID" value="Dthio_PD1598"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="138" mass="15983" checksum="67C8A82231055D57" modified="2010-08-10" version="1">MVDRNIILSKMAAVQKHVRRVKTKRDIQEHEFLQDLDRQESILFNLQMAIQNCIDLAAHVVSEKDLGLPGSTNEIFYLLEDQGYIHQDLTERMVKATGFRNLLVHEYGEIDLKVVFKVSHEDVEDLEEFARVLGDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNP2</accession>
    <name>D6SNP2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869696.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1719"/>
    <dbReference type="EnsemblBacteria" id="EFI34368">
        <property type="protein sequence ID" value="EFI34368"/>
        <property type="gene ID" value="Dthio_PD1719"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191489at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="532" mass="61262" checksum="A15AAB7A08DEF088" modified="2010-08-10" version="1">MARFFNNAGPVKPEIHYTIDPLQRVDWEEISGYIDQQRYFVLHAPRQTGKTSTLLAMMKAINEKGRYHCAYANIEGAQAARGDETKGIPAVCDALADSVELYTDHADLKSWYRSNKQEISPQHLLASVLRQWAIISSRPVVLLLDEVDALVGDTLISLLRQIRSGYAQRPEAFPQSIILCGVRDVRDYRIHQAGGEIITGGSAFNIKSASIRMANFTMEEDQDLWLQHTEETGQAFEEDIFPELWEDTRGQPWLVNALGHEVTWKITASRDRTRKIILNDYLQARENLILSRATHLDQLADKLREPRVHGVIAPLLAGEETLLQVPDDDLQYVKDLGLINLRPSLHISNRIYREVIPRELTWPVQTMISNQETVWYVKKDNSLDIHKLLSAFQQFFREHSEIWEEGFDYREAAPQLLLQAFLQRILNGGGRLLREYGLGRKRTDLIIEWPLDPQKNMYGPLQRVVIELKILRGDLEKTIQTGLEQTTDYADRAGADEAHLIIFNRDRNVSWDDKIFRLEKIYKNRNITVWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNP4</accession>
    <name>D6SNP4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869698.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34370">
        <property type="protein sequence ID" value="EFI34370"/>
        <property type="gene ID" value="Dthio_PD1722"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50331G1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1999960at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="170" mass="19459" checksum="09BF32C4754B33C5" modified="2010-08-10" version="1">MAAIIHDPVQFYKKMDRMDSEGNKSAIAARQAREIISSLADKNHLDHELRIKLSRDGEARIKNCIKFQLVDGHRMVAVKEKDWFIFLFLGTHDETDNWIKNNMNMRPDPARGKAIPPSSQSQNSREEPEQAGRAEDQEPPSIHDLDVPLHEVLDQKTLREIFPGICAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNQ5</accession>
    <name>D6SNQ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869709.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1733"/>
    <dbReference type="EnsemblBacteria" id="EFI34381">
        <property type="protein sequence ID" value="EFI34381"/>
        <property type="gene ID" value="Dthio_PD1733"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1897374at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15526" checksum="B70D0779E1FF48E1" modified="2010-08-10" version="1">MRKSIMKAGDSVVVKSGTKDPDLEIDIGGWQGRIVEIDKNQKTFLIEWDSHTLKHMPSEVIEQCEAMNWDWERMYLYQEDIDPADPRDNNEDRENISSHLNNKYSWAGLGEEGKRILNVLEKAKSGDDIDAFVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNV5</accession>
    <name>D6SNV5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK domain protein ATP-grasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869753.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1790"/>
    <dbReference type="EnsemblBacteria" id="EFI34431">
        <property type="protein sequence ID" value="EFI34431"/>
        <property type="gene ID" value="Dthio_PD1790"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="74"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="31975" checksum="850BA57B89833C65" modified="2010-08-10" version="1">MILSYHPCFYGDRFRLYAGRELDEKDTALMRRASAVILPPGRLPGLYREAVSCCANVFPDYSSRYRYPGKPGDIRLFREHGLPHPGTDLFEHTRDCLPGYLESITYPVIIKHSAGGEGSLVYRVDNPAEAAKVLGVFNGMEKSGIQSFLVQKALDAGNRTLRVVVIHEHLYSYWRVQPQAGKVQHNLAQGGFVDFYSDPELQEKGRSLVQKLCAASGINLAGIDVLFDHAGPGEPVPMLLEINFFFGLQGLGGLERYHKLLKEGVRDWILQRGLRLPPKDFPGPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP75</accession>
    <name>D6SP75_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-clamp processivity factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">DNA polymerase III beta sliding clamp subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD1923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869871.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1923"/>
    <dbReference type="EnsemblBacteria" id="EFI34551">
        <property type="protein sequence ID" value="EFI34551"/>
        <property type="gene ID" value="Dthio_PD1923"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="12">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="13">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="14">
        <location>
            <begin position="268"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI34551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="44239" checksum="ACE8169280F027C3" modified="2010-08-10" version="1">MKIIIYKEDFVEGISKASNLIPTKTGAAYLRTIWFKTDMDSVRIMSTDSNVEFTGEYRAEIVEEGLIGTPGRKISDLIRKLKSGPITMYSDEKNDILYVQQEKRHFKLPLSESSWFPELDEFPEENALAGIPGIKFKDILEKSLFCISDDDTMQGMTCLKIAPGDENQVEFCAFNGHQLSLYIHESSGLREILPEKGIMIAKKYLMDLRKWVPESDIQITITDSKIFFRTLDKKECFSLPLNMHQFPNYRDFINNYSEKLGGPLVTTKNDLMDSLERILIFNTDSQMSTLMRLGQEEIYMTSTAVDSGEAEEVVGCSYQGNLKEVVFNTKSLLEILGHIDDDNVVMKFSGPIEPCRINGENDQKYYVMTMPVQIEEETYYTEEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP76</accession>
    <name>D6SP76_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1924"/>
    <dbReference type="EnsemblBacteria" id="EFI34552">
        <property type="protein sequence ID" value="EFI34552"/>
        <property type="gene ID" value="Dthio_PD1924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="54" mass="6675" checksum="62328D9FD05A2659" modified="2010-08-10" version="1">MNKKYFIKTQKKSVSLLKKYKNYKMIHNKKYFTKYKINGIRICFCINKETLSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPB6</accession>
    <name>D6SPB6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">17 kDa surface antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869912.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1964"/>
    <dbReference type="EnsemblBacteria" id="EFI34592">
        <property type="protein sequence ID" value="EFI34592"/>
        <property type="gene ID" value="Dthio_PD1964"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1671945at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032635">
        <property type="entry name" value="Anti_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016364">
        <property type="entry name" value="Surface_antigen_Rickettsia"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16998">
        <property type="entry name" value="17kDa_Anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002721">
        <property type="entry name" value="Surface_antigen_Rickettsia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="17kDa_Anti_2" evidence="2">
        <location>
            <begin position="89"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="157" mass="16335" checksum="8B7DD1601C89AA79" modified="2010-08-10" version="1">MRTIIYLAVVLAALALIAGCGGQKHTVGGAGLGGIGGGVIGSQIGSGTGQTAAIIGGTLAGAALGGYVGSYLDRMDEMDQQKMGQTLETKPDGETSQWENPNTDISHEVTPKETYKGDEGQYCREFTTEADIGGEEKTLYGTACRQPDGTWEIVQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPC7</accession>
    <name>D6SPC7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1975"/>
    <dbReference type="EnsemblBacteria" id="EFI34603">
        <property type="protein sequence ID" value="EFI34603"/>
        <property type="gene ID" value="Dthio_PD1975"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="115" mass="12366" checksum="FADD2C68EE525FB0" modified="2010-08-10" version="1">MDNFDLIVTIVNKNTSEPLIKASKKAGAEGGTIIYGRGTGIRETKTLLGIPIQPEKEIILTIVSQDISEKVHQAIMDAGHLDKPGAGISFVVELKKVSGICHLCTLDQAPDKQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPD3</accession>
    <name>D6SPD3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869929.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1981"/>
    <dbReference type="EnsemblBacteria" id="EFI34609">
        <property type="protein sequence ID" value="EFI34609"/>
        <property type="gene ID" value="Dthio_PD1981"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1872945at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="142" mass="15668" checksum="B97471092D671830" modified="2010-08-10" version="1">MIRRIFVVDTNVLVAGVITSRPDAPTARLVDAMLEGRIVYLLSPELLREYEQVLMRPAIARLHGLSSPDIETILTEITANAIWREPLADTKHSAPDAKDSHIWALLANEAQAILITGDKPLIDNPRPGSSVITPASWVDHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPN1</accession>
    <name>D6SPN1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870027.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34707">
        <property type="protein sequence ID" value="EFI34707"/>
        <property type="gene ID" value="Dthio_PD2079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="503" mass="57947" checksum="7E36ABBFF22E3210" modified="2010-08-10" version="1">MATYKYPSLKFTSKEPKTSVVPLFYYVDVLEGGKSVERYEWIAPNARNSFDVYNLGFFDNNSQQQLDIGHYQNQAYKVTSLEMLKKFKEVAPESHDLISEPMLPGKDDLEEQFISKVTQLQFEKEKIKGQWTHIVTAFTEILRNHFRKAAEEASLNHSLSNFFKGLTIGRSNTTYGFFMKGIKTAYDGLGFYKKTYSGLRFKNFGMNELISYIRSHRSAYPKNRSLSFDLVPGLTKISHSKTTRRTPTGPFTITSITDKGYKGLPREYMEHIERSMKHWTTHNQKLPFLKKQNVLKPGQVFQDRFMKGQTQRPRIVHEYGFRGDGRSPLVIYLSGGLHPNAVRHYDKEDARQKFEKYRSELNQRARDKYSGHLTPHFDPYLHQHNYDAISVFLSVSRSPEVALSFVNMGGGNGNIYVVRATGAIDQEGTFKRVQYPGEAEISVAGGVDWEDIVAVRPVYNGVPANYYYMNTRNKWHQKDKQVQSDVLAALMNISYDPDLDMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPP4</accession>
    <name>D6SPP4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870038.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2093"/>
    <dbReference type="EnsemblBacteria" id="EFI34720">
        <property type="protein sequence ID" value="EFI34720"/>
        <property type="gene ID" value="Dthio_PD2093"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1140711at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="329" mass="37137" checksum="F273981BA9970A39" modified="2010-08-10" version="1">MQIELIQKNLEEVENPGLETTDPRLMEISGLAQSGDYHGAAASAEALLQEDIYDVRLLGFFIYGLLFEKGPAGFGDVFASLAWFLENNWSATGPVKKRNKHAMTSFRWLFNQSLKKLQYEESFKGDTWQQWLAVTDSDDVEQALDTARELQKAMSECLEDEAEPLLDLLSKIVQWLRSFQPMVYREQESDPEEMQAEEQEPGAGEGQPESSQVSASKPASAPRTPESTTGGVWVEGSYHLLVLMKKLEIFQSLCQSQDYAKAAVVADDIMDSISQFDPKLYLPKLFSGFFMCLSANSQDILGYQEMKDSPEWQIMREYLNVDPDGFVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPT7</accession>
    <name>D6SPT7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870081.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2139"/>
    <dbReference type="EnsemblBacteria" id="EFI34763">
        <property type="protein sequence ID" value="EFI34763"/>
        <property type="gene ID" value="Dthio_PD2139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="129" mass="15713" checksum="F05EBCEF0D3D6CBE" modified="2010-08-10" version="1">MYHEQMYHIGEYILSHKGLQNYFKQEGANAKSFWRQFRSDMMRQRPETIKKYLCSEDSRLNHHEYADKFGKELYEMFFSEDNDQEQVRMYINAVIYFCLEMDASFKVQDITDKNKKQSLKTALHIWEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ21</accession>
    <name>D6SQ21_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipopolysaccharide export system permease protein LptF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2238</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870161.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2238"/>
    <dbReference type="EnsemblBacteria" id="EFI34847">
        <property type="protein sequence ID" value="EFI34847"/>
        <property type="gene ID" value="Dthio_PD2238"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030922">
        <property type="entry name" value="LptF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04407">
        <property type="entry name" value="LptF_YjgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="390" mass="44295" checksum="27AF34FBBF2D7EEA" modified="2010-08-10" version="1">MKILHRQIIKEVGTIFLVTLASMLSLIVIGRMIDLKDIFVGQSIQILYVIKSFFYLGPSFLSMVIPIACMLSIFLCFLRMSSDRELTALQTSGISIRSLVLSPLLFSLGAMGFTLYVTLHLTSWGIDNFRETAVEMVREQTEVSMQPGVFHRMIPDMAIYVHNRDPGTSELKEVFISDDTVPEAPLTIVAPTGRMLSDKEEGMLYFILDDGRIYRQDQEEHSLVSFGEYRLRLDLFSLLGDAGLRDKRPEEMSWGELQAYKDDAQADSRQYRLAVLEEHKRFSLPLACLILGLFAVPLGLTLQGLGRNWGLLLAMSCFLIYYSLFTAVYGLGEAGTLNPDLAMWMPNIFFLVLTLGGFYFYSQGREIDLGQVLRSFVPWLHKRDENQENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ87</accession>
    <name>D6SQ87_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870227.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2304"/>
    <dbReference type="EnsemblBacteria" id="EFI34913">
        <property type="protein sequence ID" value="EFI34913"/>
        <property type="gene ID" value="Dthio_PD2304"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="13983" checksum="D56558B2623433E8" modified="2010-08-10" version="1">MTNEVLKREAQNVPRFSPSTDIIEKEDGFHIYLDMPGVTRENLNIDLQDTDLEVSARPEFPKVENASNIHMEFGDCEYRRSFTISDVVDRNNIKATMKNGVLELYLPKAEKAKPRKIQIEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQJ4</accession>
    <name>D6SQJ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monovalent cation/proton antiporter, MnhG/PhaG subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870334.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2414"/>
    <dbReference type="EnsemblBacteria" id="EFI35020">
        <property type="protein sequence ID" value="EFI35020"/>
        <property type="gene ID" value="Dthio_PD2414"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2051355at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="11426" checksum="4B95EC74C0826E7D" modified="2010-08-10" version="1">MVVIIDALAIIFMLAGAVFMLAGSIGILRFPDVYCRAHAATKVDTLGIMLFILGLALFEGFNLVSVKMLLVAAFVALTSPVAAHALSRRAMLHGVKPWTRKQKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQM8</accession>
    <name>D6SQM8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2448"/>
    <dbReference type="EnsemblBacteria" id="EFI35054">
        <property type="protein sequence ID" value="EFI35054"/>
        <property type="gene ID" value="Dthio_PD2448"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="226" mass="25473" checksum="D563930688FE29B3" modified="2010-08-10" version="1">MQEKNNQNMLLELDRVSHFFDQRLVFKDITLSLGKGQVLLLAGPNGAGKTTLVNIMTGLIRPVHGTVQAGVPSGKTAYLGHHTFIYPGLSALENLRFWAGMYSLDRSEKEFLDLLALVGLKGFAYENARTFSRGMSQRLSLARVLMLEPELIFLDEPATGMDAQSRRMLREEIGKARQRGASMVWVSHSLEEDLDLADFVLYLENKKQAYLGPAKDFRDHCRENQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQU1</accession>
    <name>D6SQU1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870431.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2511"/>
    <dbReference type="EnsemblBacteria" id="EFI35117">
        <property type="protein sequence ID" value="EFI35117"/>
        <property type="gene ID" value="Dthio_PD2511"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667451at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="168" mass="19869" checksum="8F5738893B45520A" modified="2010-08-10" version="1">MQTSEEKTKEAIRDLTRVFQFELWLRFYFISDDEGSLSINLDEELLEKMQEKYGHLADLARTLCEKEITPEVCRQAIVEHIMHQFDGIKYDVGFVPRIMDHAVFKGEIQLFNTWAGLHEEQLDRKVLDFDRWIEIYEEWKASESAQKVNLALNIQDTEHHHPGSDKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQV3</accession>
    <name>D6SQV3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MJ0042 family finger-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870443.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2523"/>
    <dbReference type="EnsemblBacteria" id="EFI35129">
        <property type="protein sequence ID" value="EFI35129"/>
        <property type="gene ID" value="Dthio_PD2523"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAYQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1850039at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021834">
        <property type="entry name" value="DUF3426"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011723">
        <property type="entry name" value="Znf/thioredoxin_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11906">
        <property type="entry name" value="DUF3426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13717">
        <property type="entry name" value="zinc_ribbon_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02098">
        <property type="entry name" value="MJ0042_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Znf/thioredoxin_put" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="270" mass="30649" checksum="524D4BE7EFD7A272" modified="2010-08-10" version="1">MTVQCPNCSTKYRFDDSRLKEDQKVRCTRCKHVFTLSFLNDEDQAYQQPPDPGDSLRESADTAPEKPSRDDMHVEITPEEKTGKAGRPRLKKIGAVLALFLIVAASLYVALPKIAQHVYIPFVSSERDAEEVPRKEVFTEEDVRDISLENVRQYFVNNEETGQLFVVEGRAVNEFDSPRARIKLRAALYDNQEQVVQEKEFLAGNAASLFQLQVSSRDELESTLTSQLGILTNNKHIEPGESTPFMTVFFNPPEEVQEFGLEVIEAHIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR00</accession>
    <name>D6SR00_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Relaxosome protein TraY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TraY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870490.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2574"/>
    <dbReference type="EnsemblBacteria" id="EFI35176">
        <property type="protein sequence ID" value="EFI35176"/>
        <property type="gene ID" value="Dthio_PD2574"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008876">
        <property type="entry name" value="TraY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05509">
        <property type="entry name" value="TraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0184">Conjugation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8386" checksum="A2286E8969AA11F8" modified="2010-08-10" version="1">MLAIRLPEEIEKRLGDLAEKTGRTKSFYAREAIMEHLEDLEDYYLAVHRLENPPERVWSLEELEQGIDLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR50</accession>
    <name>D6SR50_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SapC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870524.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0489"/>
    <dbReference type="EnsemblBacteria" id="EFI33166">
        <property type="protein sequence ID" value="EFI33166"/>
        <property type="gene ID" value="Dthio_PD0489"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1512520at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010836">
        <property type="entry name" value="SapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07277">
        <property type="entry name" value="SapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="250" mass="28430" checksum="8F8320F53E07C40B" modified="2010-08-10" version="1">MYQNTQALDKSQDIKFTQVSNYHFAAKENFCPVFLQELPQVVREYFICFPNNQTDLPHALLGFQQNTNQYVSEDGSWQAEYIPAYIRRYPFILAKKEDSAQDEFTLAADINAPHFEQATGEPLFTLNNQPTELMQNKIQLLKGIEQQRIITQQAVQEIEKAGLFKMEQLTIKLKDQPVASIGGLRMIDEEKLKGFTSNYGPTMELIAAHLFSKANLQYGVLAGKKRAVPEPGPVDPGFSFGDDDIIRFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR73</accession>
    <name>D6SR73_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(P)ppGpp synthetase I, SpoT/RelA</fullName>
            <ecNumber evidence="6">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870547.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0515"/>
    <dbReference type="EnsemblBacteria" id="EFI33189">
        <property type="protein sequence ID" value="EFI33189"/>
        <property type="gene ID" value="Dthio_PD0515"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="387"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="646"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="720" mass="81825" checksum="D380C7C517263F43" modified="2010-08-10" version="1">MVRINEILDKVSGYLSGPDQALIQKAYVFSASAHAGQIRLSGEPYLSHPLEVSDMLADLHLDADTIAAGLLHDTVEDTKASLEEVRDQFGEEVARIVKGVTKIGKMSFDSKEEAQAENIRKMILAMADDIRVILVKLADRLHNMKTLEHQSSFKQKAVAQETMDIYAPLANRLGLYRLKIQLEDLSLRYMKPDVYFQIQEGVNKQKVVGEQYIQKVCQNIEEILEQNSIEGRVSGRMKHIYSIYHKMVQQGLSLDQVFDIIAFRVLVQSIKDCYAVLGLVHSIWKPVPGRFKDYISMPKANMYQSLHTTVIGPDGERIEIQIRTEEMHKMAEFGVASHWRYKEDGKNRFKDKDAERFSWLRQILDWQEELKDPREFMASLRFDLFEDEVYVFTPRGEVKELPEGATPIDFAYMIHTEVGDRCAGAKVNGKLVPLNTVLKNGDTVEIITDPHRHPSRDWLRLVKTAKARTRVKQWIRNEERQQSIALAKEVLEKEGRKMGININKVLKQGQLQPIAADFSYKSVDDLLSAVGYARITPRQVLNRLLPREEQRPAKGEAGDQQEKPEEKPAPQVAKKEGVQIKGVGDVLVRFSKCCNPLPGDPIVGYISRGRGVTIHTADCANCQEMEPERKLEVSWAGETDKDFPAKIKMLCQNRKGVLAKISELLTKEDVNIDAGTFKSNVDGKTEVVFTIMVQDSNHLYSTIEKLRKLSEVQEVIRIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR88</accession>
    <name>D6SR88_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Flagellar basal-body rod protein FlgG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Distal rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5 7">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870562.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0530"/>
    <dbReference type="EnsemblBacteria" id="EFI33204">
        <property type="protein sequence ID" value="EFI33204"/>
        <property type="gene ID" value="Dthio_PD0530"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1488472at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009426">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012834">
        <property type="entry name" value="FlgG_G_neg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02488">
        <property type="entry name" value="flgG_G_neg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="8">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="9">
        <location>
            <begin position="180"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="260" mass="28397" checksum="1764CCE108760B00" modified="2010-08-10" version="1">MMRSLWTAATGMAAQQMNIDVTSNNLANVNTDGFKKSQAQFEDLMYQTLKVAGTENLTGDRVPTGLQVGMGTNPLSVHKIFTQGDYKQTGNPLDLTIEGDGFFQVMANDEVRYTRAGSFKPDQDGRIVTANGYPLQPEFHIPEDTARVHVDEQGNIVCVDGDDNVIAEGEIPIYRFMNPAGLNSAGRNLYSETEASGPATEGVPGEENFGSIRSGALESSNVEIVDEMVNMIIGQRAYEINSKAIQTSDQMLQMANQMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRB3</accession>
    <name>D6SRB3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870587.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0555"/>
    <dbReference type="EnsemblBacteria" id="EFI33229">
        <property type="protein sequence ID" value="EFI33229"/>
        <property type="gene ID" value="Dthio_PD0555"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="18"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="278" mass="31392" checksum="29D06A0539833546" modified="2010-08-10" version="1">MQDLYLEKKNRILSVKDLPTLPIVLDEVTELVQDPSSSTDQIAKVISKDQVLSAKVLKMVNSPIYGFPRRIGTIQHALVLLGFNVIRGLIISTSVFDIMAKNMMGLWEHSLGCATACAGIAKQAGLKDPEEYSVAGLLHDLGKLVSIIQLPEIKEEVDALVLEKDITYYQAEREVMGFAHDRINAWLADHWNLPLRLREGLVWHHRPKSAQHYPDVACVVHLGDFLSRIFQVGNSGDDQVNYLDKYIFKVLNLRQEDLEKSLDHLDRELVELTGFIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRD9</accession>
    <name>D6SRD9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidoglycan-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pal</name>
        <name evidence="12" type="ORF">Dthio_PD0581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Pal lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870613.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0581"/>
    <dbReference type="EnsemblBacteria" id="EFI33255">
        <property type="protein sequence ID" value="EFI33255"/>
        <property type="gene ID" value="Dthio_PD0581"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1544679at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02204">
        <property type="entry name" value="Pal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039001">
        <property type="entry name" value="Pal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014169">
        <property type="entry name" value="Pal_lipo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02802">
        <property type="entry name" value="Pal_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OmpA-like" evidence="11">
        <location>
            <begin position="85"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="200" mass="23076" checksum="3FEAA0BEB83AA470" modified="2010-08-10" version="1">MKNRTVMLLALLLGLIMFAGTGCGKRAVEAPTDPAAEELTEEEKARLEEERLKEEMERQALEERRLQEERMERERDEVDAEARIQDAMEEITANRIHFAFDSYELDADARSALQKISEHMKRFDELRLVIEGHTDERGTAEYNLALGERRARAAYEFLVLLGVSSDRLQIISYGEENPLVDESNESAWAQNRRAEFKVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRH9</accession>
    <name>D6SRH9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase with PAS/PAC sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870653.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0621"/>
    <dbReference type="EnsemblBacteria" id="EFI33295">
        <property type="protein sequence ID" value="EFI33295"/>
        <property type="gene ID" value="Dthio_PD0621"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="318"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="456" mass="52658" checksum="0FA594847B76BFD0" modified="2010-08-10" version="1">MIFHEIQDRFWILNQLPLGIFILDQDMRIQFWNRIMQEWTEHDARTVIGQRLPDMYPELKQPRFEPRIQAVLDGGPPAVFSSHLHGWFIPITNRDGDKRLQNTTIASIRVQESSQWTRLALVTIQDVTELNQRISEHRKVRDQVVEELKKRREIEQRLRREKAFVSKLLDTVDSLVVLLDNEGRIIHFNRACERLSGYSFQDLQGKEIFKRLIPPEEAETVRSFFSPDFANLPHHFENYWLTRAGEKRLIAWSNCIINDEEGNPDYVLGTGIDITEQRRMQERIEHMAMHDGLTGLPNRNLLQDRMEMAIAAAKRTGNRVALLFLDLDGFKAINDNYGHSTGDEVLTLVSRRLKELVRASDTVARFGGDEFVILLTDTGKLEDAKQVARKVAWQLSRPYILPSGEHQLGVSMGISLYPDDAESAEDLMRLADKAMYRVKKSSGDKETCFLASCENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRK8</accession>
    <name>D6SRK8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870682.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0651"/>
    <dbReference type="EnsemblBacteria" id="EFI33324">
        <property type="protein sequence ID" value="EFI33324"/>
        <property type="gene ID" value="Dthio_PD0651"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1283891at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019925">
        <property type="entry name" value="DNA_repair_protein_predicted"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03623">
        <property type="entry name" value="TIGR03623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="623"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="904" mass="103066" checksum="C55546FE5FC798D4" modified="2010-08-10" version="1">MPQTHYLSEKDVFQALEEGALLLTVNRRLSRSLLQRFTSHQASTGRTAWETPDILPLSSWIMRCMEEITYHHPDVSHPLPITRDQELSLWEDIIRQSPHSRGLLHLEETARQAARAWTLFEQWNLQDQQDPALWSSPDHRAFLEWSTAFRDYTQGRGWMEEARHTRHVARMFEKGCLPCPAHLVLAGLENLSPVQEHILDVLDGLGCKINHLEPARNDPAITLMPLADREQEMRTCALWVRTKLESDHEQRIGVVVPDLYSVRQEIIHTFDAVLHPDTAFEPLPPEKRAYDLSLGRPLSGYPLIRSALHLLDLRLDPLPLETVSAVLNSPFLKGAKSETPARSGLETLLRKTREPQISFSFLLDKAADSSKSWSCLVLARSLKAFQARIKELPSTQPPSAWAQDLDLLLQDLGWPGDITLSSHEYQTVQAFNACLKRLAGLDRVMPSTGMSQATQTLSRILNETIFQPEPPEVRVRIMGMLEAESESFDELWIMGLTDQAWPQSPEPSPFLPVSLQKHLDMPRSSPQHELDYARRIMHRLLQNTSRAILSYPCREEDLELLPSPLLREISGLEFNEPGLLPDPDPWAGLSPGEQLKYFQNEQAPPLSQASRAPGGTGVLRSQALCPFQAFARHRMHARSLEEPVVGLGPPERGIIMHAALEYFWQSCRDQAALLNLTGDRRLQMIDQAVDQAIREMHSQRPQTMTSRFQELERERLQDLLQEWLALEEQRQPFQVQELEKRSNISINGLELNVVADRMDRLEDGRLVVIDYKSGRHAMSEWFKKRPVEPQVPLYTLFCPEHVAGVYFGVVRKGECAFVGLGQEDGIVPGCKGFASHKLTSHYQHWDELLQDWKKSLEKLAQEFMQGQARVDPESPNACRQCDLESICRIFETGQPFTQEPPDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRM4</accession>
    <name>D6SRM4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="12">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">thrS</name>
        <name evidence="14" type="ORF">Dthio_PD0668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="12"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870698.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0668"/>
    <dbReference type="EnsemblBacteria" id="EFI33340">
        <property type="protein sequence ID" value="EFI33340"/>
        <property type="gene ID" value="Dthio_PD0668"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="13">
        <location>
            <begin position="242"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="12">
        <location>
            <begin position="242"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI33340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="646" mass="74228" checksum="26A7668DACAACD61" modified="2010-08-10" version="1">MVKVSGAPEEIQLSTGATCREILSKALSGKKFKEAVACRCEDRLYDLGSEVDEQCGVLEPVSLSSPEGLKVLRHSAAHIMAEAVKTIFPSARVTIGPDIEHGFYYDFDYERPFTPEDLEKIEAEMARSIAQDQPFERVVMSREEAKKVFLDMNETYKLEILDELEEDEVSLYRHGDFIDLCRGPHVPSTGYVKSFKLTSVAGAYWRGDEKRPMLQRIYGTAFASDKELKKHLTRLEEARKRDHRKLGAQLDLFSFSEEAGPGMPIFHPKGALIRTILEDFERKEHLRRGYQIVQGPQILRRELWEKSGHYDNYRENMYFTHIDEQVYGVKPMNCLSHMLIYKSKLRSYRDLPLRYFELGRVHRHEKSGVLHGLLRVREFTQDDAHILCRPDQLQDEITGVVNFVRDVMGLFGFEYVVEVSTRPEKHIGSSEAWEKSTRALTSALDALDMPYEINPGDGAFYGPKIDIKLKDALDRKWQCATVQCDFTLPERFDLTYTGEDGRKYRPVMLHRVVLGAIERFLGVLIEHYGGAFPTWLAPVQARIMNITDAQAGYVHDCADRFRQMGIRVEVDDRNEKLGYKVREAQMEKIPYVLVAGDQEVQESGLNVRLRGGKNLGLMSIQEVADQIFQDMDEPFKKGGLSYRYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRM5</accession>
    <name>D6SRM5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.262</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.262" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870699.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0669"/>
    <dbReference type="EnsemblBacteria" id="EFI33341">
        <property type="protein sequence ID" value="EFI33341"/>
        <property type="gene ID" value="Dthio_PD0669"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1414545at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="36392" checksum="4743D0AF7272FCFB" modified="2010-08-10" version="1">MSLVLYTPGDPNGLGPELLMLADLDRFVRDHALLVIGPEKALEHHCRQMDAQKFWKRIDSLDRDRLDKPGIYLFEPEGLKDFEPAPGKEDVQGGFAAGVSLSTACEFLKYNQNVVLTTGPLNKNLLQEAGFDFPGHTEFLAHQFGMAQDQVCMHLCGDRLRVSLVTTHPPLHLVPELVTQKKILRCLRLTHAFMVRLGEGHKPLAVCGLNPHAGEGGKTGTEETETVIPAIEQARSEKINVQGPFPADTVFYRAWNNEFSAVLAMYHDQGLAPLKLVEFGRCANVTLGLPVVRTSVDHGTGFELVGTGRASPRSLEKALDLALRLAPEDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRV9</accession>
    <name>D6SRV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870777.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0759"/>
    <dbReference type="EnsemblBacteria" id="EFI33425">
        <property type="protein sequence ID" value="EFI33425"/>
        <property type="gene ID" value="Dthio_PD0759"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503396P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2169960at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="176" mass="19173" checksum="C49FD6D5A4B9833A" modified="2010-08-10" version="1">MILSLLFLTAGLLALACGIVVLVRPGAVNRLSLPVRQALQAVNPSIRLERYYYRHHRITGPVTVLGGVLLCFAAWLLSGSAPAENSLLVFYQALTVVFFIFGAAIAVIGVVVTIRPSALKPLEKKSNRFISKEDIINLLKRLRQGYLNLTARHPRVFGLLAALGGLLLIFLALQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRX5</accession>
    <name>D6SRX5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG domain protein DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870793.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0775"/>
    <dbReference type="EnsemblBacteria" id="EFI33441">
        <property type="protein sequence ID" value="EFI33441"/>
        <property type="gene ID" value="Dthio_PD0775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046257">
        <property type="entry name" value="DUF6290"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19807">
        <property type="entry name" value="DUF6290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="75" mass="8877" checksum="10B7FD820B39E219" modified="2010-08-10" version="1">MPTSVRLPNEYEQRLDYLAKQTGRSKAFYIKQLIMEHLDDLEDVYLAEQRLEQLRQGNDELINGDEFWSGLDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRX8</accession>
    <name>D6SRX8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide binding protein PINc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870796.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0778"/>
    <dbReference type="EnsemblBacteria" id="EFI33444">
        <property type="protein sequence ID" value="EFI33444"/>
        <property type="gene ID" value="Dthio_PD0778"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="14974" checksum="E2BBAE94D01369FA" modified="2010-08-10" version="1">MKLVLDTNVLIAAFIARGTCHELLEHCALRHTIFISDFILNEFETNLVSKFGFTAEEAAAAAALVHTRAVMHSPEPLSERVCRDRDDDNVLALALAASADCIVTGDKDLLLLAQYRGLPVVAPGEFWQFENSYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRZ1</accession>
    <name>D6SRZ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870809.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0791"/>
    <dbReference type="EnsemblBacteria" id="EFI33457">
        <property type="protein sequence ID" value="EFI33457"/>
        <property type="gene ID" value="Dthio_PD0791"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200399at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088172" evidence="3">
        <location>
            <begin position="28"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="417" mass="45989" checksum="BD563CBEC5CF0FC5" modified="2010-08-10" version="1">MAKMIAPYLLTALTVLLMGGFSGCVPAGEDEPEDVVRPVKLMQIKKPSPEINRILPGKLRPQRETRMSFRVANELQSLEVDTGDYVHKGQVVARLDPRDFRLAVQNFEGSLGEARSNLKAMQEGARTEDVISLEAELRAAGSAVRESQLQYRRHKELYEQGAVARAELDRTETALEEARGRKRHLEMELQKALIGARDEDIQAMQSRIESLEAALEEAQSALQDSVLRAPFSGYIAEKHVENHENISAGQPVATLQDLTRLEVKFGLPEQLVVQKDDIKEVYCILDAYPGFPLPARLKEVSTDARELSYKATAILTMPENIRALPSMAAQVHISIAPDEDGDQLVTVPETALFTDSQGKDRVWVYDSGSSRVQSRQVRTGELTSAGVQVLSGLGAGDLVVTAGAHFIQEGQKVRPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS50</accession>
    <name>D6SS50_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="4">4.1.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA photolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD0850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA photolyase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870866.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0850"/>
    <dbReference type="EnsemblBacteria" id="EFI33516">
        <property type="protein sequence ID" value="EFI33516"/>
        <property type="gene ID" value="Dthio_PD0850"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184000at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008148">
        <property type="entry name" value="DNA_photolyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032673">
        <property type="entry name" value="DNA_photolyase_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00591">
        <property type="entry name" value="phr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01083">
        <property type="entry name" value="DNA_PHOTOLYASES_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="11">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="448" mass="51850" checksum="8E5DE63DE0E08C9D" modified="2010-08-10" version="1">MRVHPRRIQEIRTGNQDSGPVIYWMSRDQRIKDNWALVHAQDLALHLSRPLRIVFCLADGFLQAGLRQFDFMLRGLHECAGVAESLNIPLDLVRGEAGLVLPAYLEKHRASFLVMDFDPLRIKKSWQKAVLDKTGIPAHLVDAHNIVPCWSTSQKQEYAARTIRPKIHRQLEEFLEDYPDVKPHPYPAQAGTGVDPDGLLQEMDLDKTITPVRWLSPGPAGAGEVLDDFMAHRLSLYHEQRNDPNMQVLSNLSPYLHFGHTSAQRVALQVKKQLDTPVQSREAFLEELIVRRELSDNFCHYNQNYDNFQGLPAWAQKTLDKHRSDSRDYLYEPQALEQGLTHDPLWNAAQTEMVKSGKMHGYMRMYWAKKILEWSRSPEQAIDTAIYLNDKYELDGRDPNGYTGIMWSIGGVHDRGWKERKIFGTVRYMNYNGCRRKFNVDAYIQKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSC0</accession>
    <name>D6SSC0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD0921</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870936.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0921"/>
    <dbReference type="EnsemblBacteria" id="EFI33586">
        <property type="protein sequence ID" value="EFI33586"/>
        <property type="gene ID" value="Dthio_PD0921"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="10">
        <location>
            <begin position="95"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="481" mass="53528" checksum="DCC8C8CEE8A57E0F" modified="2010-08-10" version="1">MTMDEFPAYRGDLRYHCLECKSVYPGDELHYTCPECSGVFLLQDHNFSELKKTSGEDWRAVFDQRAAGKMTQMQGIFRFFELIAPVVDKEDVVYLGEGNTPVIESSPRLQKNVGRKMAFKNDGQNPSASFKDRGMACAFSYLNQLVKKNNWDQVLTICASTGDTSASAALYAAYVDGPVKSVVLLPQGKVTSQQLSQPLGSGSVVIELPGVFDDCMRVVEYLADNFRVALLNSKNPWRILGQESYAFEIAQWSNWDMAGRCVFVPIGNAGNITAVMNGFLKLKKLDIIDELPRIFGVQSTHADPVYRYYRQNPGDRSYAPVEVTPSVAQAAMIGNPVSFPRVRELAAKYQQEQGEDAFNVVHVQEQQIIESMLLANQNGHIACTQGGECLAGLIQARDQGLVGADEFSILDATAHALKFSGFQEMYFNRSFSPGYGITPRQEYINQPQSVLSEEDKERMSKDEFTRAAVNEMVRILGLQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSG1</accession>
    <name>D6SSG1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870977.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0962"/>
    <dbReference type="EnsemblBacteria" id="EFI33627">
        <property type="protein sequence ID" value="EFI33627"/>
        <property type="gene ID" value="Dthio_PD0962"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="849"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="874"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="904"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="953"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113719" checksum="E68BFECC4173940E" modified="2010-08-10" version="1">MIWNLCIRRPALTVVIFLVLAIFGVYGFTQMPIQENPDVEFPVVSVLVVLPGAAPEILEQEVVEPLEAELSTIEGLKELVSTAEQESATVTAEFELWRDQDLAAQDVRDAVERARRHLPDDAEAPVVRKMDMDAGPIMWFTLQGDERWDDMSMSRYAEDVLKPRMETLRGVGRVIVGGSRDYAVRVKIDPELLAAHRLTIQDVVDTVQMENVDIPSGRIEGKTREFTIRTRARFSEAEPFNDLVIDHRDGSPVRLSDVGEAVDGVESYRRLARFNGEPTVGLGLVRQTGANTVEMAEAARESMRRSAENFPPGLEYQEAMDASEYIEENIRDLQTTIFIAATMVVFVVLFFLRSGRGTIIVALAIPTSLLTGLAAINVLGFSINVLTMLALILVIGIVVDDAIVILERNFRHMEHGADPLPAARVGTTEMAFPAIANSLSLGAVFIPVAFTGGIIGRFFYEFGLTVAVTVFASTFVALTLTPMLCSRLLKYKERKSWFFKMSERHLNHVEAIYAWVLARAFKRRALVVVIALLAFGAGIMAYMNIPKEFAPDEDRSRMMIVFETPQGATLPETDSFAARIEKMLAEDPNVSHTFLGIGLSRGGGPGHPNEGVAFVTLVPRDERDKHQTEIMQQYRQRLAQIPDGRAFAVDITPGGVGGDPVEVVLQNPDLQELDIVQEQVVDWMESRSEYYVGVRSDLELDRPQVDVSIDREKAAEMWVSATAISQSLRYLFGEVDISHVDREARRYDVITEIKDRGETTPDALRHVYLRNQRDELVSLDNLVHIQETIGPSEIHRFDRVRSASVTASTPPGVALGDAVDELETYLEAELPAGTDYRMAGMSEVFEESFYYLALALIFAIIFIYLVLSAQFESFIYPLSIMTALPLATVGAFGILWLLNLNFSVYAFIGLIMLMGLVTKNAILLVDYTNVLVARGRPPVQAAQEAARERFRPVVMTAISTILGITPIALGYGAGGEARVPLGVAVAAGLFTSTALTLIVIPVVYTLYDQLQNYILRLFGKQPKGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSI1</accession>
    <name>D6SSI1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870996.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0983"/>
    <dbReference type="EnsemblBacteria" id="EFI33647">
        <property type="protein sequence ID" value="EFI33647"/>
        <property type="gene ID" value="Dthio_PD0983"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="133"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="393" mass="44562" checksum="172DA38EF8342FC7" modified="2010-08-10" version="1">MKDYKVLFVDDDVNILEGFKRSLRRNYSVDTATGAMEGLKAINEKGPYAVVVADLKMPGMDGIQFLGRVRELFPESVRIMLTGHEDLDAAIEAINEGSVFRFLTKPVPPHLLTRTLDDAIAQYRLIVSEKEIMESTVSGVVGALTDVLSMVNEDAMARAARIKRFVRDLAVHMGETDVWFYETGALLSQIGGLALPENIRLKIKNGEKLTPEEKQTFSQHPMIAADIISRIPRLEEMSRMISQQEKYYNGQGFPEDGIRGKDIPLGARILKVVLDYDLLMNRGYSRKNTLLRMLDRKGRYDPAVIRNFIEVLQMEDEYELKQVRINELVPYMVVTEEIYSLSGMLLLRSGSELSLNQVDKLRNLDETYGVKQPFSVLVPPQKLREKKKAKESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSM3</accession>
    <name>D6SSM3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytoplasmic chaperone TorD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1028"/>
    <dbReference type="EnsemblBacteria" id="EFI33689">
        <property type="protein sequence ID" value="EFI33689"/>
        <property type="gene ID" value="Dthio_PD1028"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1995553at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="207" mass="24235" checksum="2D81C1242A6EF7AE" modified="2010-08-10" version="1">MKMQVYKSLADCYFQPDEKLVQAVQRINPAIEEWDQDLLEPALEMQKVVESRDKEMLDLKKEYSRLFVGPFELAVPPYGSIYFQHNMQNQQIMDDSAVEAQNAYRKAGVNMSEDFNDPPDHIAVELEFMYYLLYHENQALENKDQASAIDFRTQRLDFLKRHLGLWGPVFADTLFKNTSSDFYRHLARLTKSVILKDKQELGLTRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSN9</accession>
    <name>D6SSN9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871054.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1044"/>
    <dbReference type="EnsemblBacteria" id="EFI33705">
        <property type="protein sequence ID" value="EFI33705"/>
        <property type="gene ID" value="Dthio_PD1044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="11676" checksum="715C53401DDCD3B7" modified="2010-08-10" version="1">MSTPGKVVRLEAGLILPDSARKQAVKPWSAPWKGRRVARRMLVTSLKRSGAFKRGVSSNHLPEVCRFKLLQIMTLPGRRYAEDPAMNCRRRRQGNGPDLEPGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSP0</accession>
    <name>D6SSP0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Redox-active disulfide protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1045"/>
    <dbReference type="EnsemblBacteria" id="EFI33706">
        <property type="protein sequence ID" value="EFI33706"/>
        <property type="gene ID" value="Dthio_PD1045"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005243">
        <property type="entry name" value="Redox_disulphide_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36450">
        <property type="entry name" value="PTHR36450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037031">
        <property type="entry name" value="Redox_disulphide_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00412">
        <property type="entry name" value="redox_disulf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037031-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037031-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="8683" checksum="9C4A4C246B664E4F" modified="2010-08-10" version="1">MMEIKVAGPGCAKCKQLEDLVNEVVAEMGMDAQVSKITDFSEIVQTGIMTTPGMIVNGKVKVSGKVPTKAEITQILTTEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSQ6</accession>
    <name>D6SSQ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Auxin Efflux Carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871071.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1061"/>
    <dbReference type="EnsemblBacteria" id="EFI33722">
        <property type="protein sequence ID" value="EFI33722"/>
        <property type="gene ID" value="Dthio_PD1061"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="307" mass="33425" checksum="87970AEB56058F9F" modified="2010-08-10" version="1">MHFFTIFNNSILPIFLIIISAFIYNHIFRPEIKPLASLALALFAPVLVFDSMTRHAVSFSDLGVPFVFMLFLTALLIALGILLSSAMRLGPGEKNSFILGISMINVGNFGLPLIHLTFGQEAVPLSIVYFVIFNIPLCTLAIYMSSDKTRLREILLDVVRIPIFHAFLLALVFSWLKIPVPGGIQQGLQLISAGAIPLLIFILGLQLAAISLSSLKDRLLRFAAIISAASAVRLVISPLAAVCILCFFPVSQLEMSVAVLQTSAPAAILPLMYAIKFNKSPELLAAIILFTTILSGITLPVLIQYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSW6</accession>
    <name>D6SSW6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">surE</name>
        <name evidence="7" type="ORF">Dthio_PD1121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871131.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1121"/>
    <dbReference type="EnsemblBacteria" id="EFI33782">
        <property type="protein sequence ID" value="EFI33782"/>
        <property type="gene ID" value="Dthio_PD1121"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="28404" checksum="A388C4A8600771E7" modified="2010-08-10" version="1">MEILLTNDDGIHALGLKALFTALAGAGHKVHVVAPMTEQSAVGHSLTIFSPIKVKKIRENNFKGLGISGTPVDCVKWAMHFHLQKKPDLIVSGINNGANVGIDILYSGTVSAATEGALAGVPSLAVSIDDFRPLDLSHQAHWVQAFIQRFDWTRLPYQNVLNLNFPACEVHEARGVRLCPQTTVVYRDFYQLREDPRGNPYYWLGGEIPMHRVDPEADRALLSENYITLTPLQFELTNHEVMDELQEALSSVNIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST00</accession>
    <name>D6ST00_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="7">2.4.1.129</ecNumber>
            <ecNumber evidence="6">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Dthio_PD1155</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="7"/>
    <dbReference type="EC" id="3.4.16.4" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871165.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1155"/>
    <dbReference type="EnsemblBacteria" id="EFI33816">
        <property type="protein sequence ID" value="EFI33816"/>
        <property type="gene ID" value="Dthio_PD1155"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031376">
        <property type="entry name" value="PCB_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17092">
        <property type="entry name" value="PCB_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Transgly" evidence="19">
        <location>
            <begin position="55"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PCB_OB" evidence="20">
        <location>
            <begin position="317"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="18">
        <location>
            <begin position="445"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="757"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFI33816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="794" mass="89209" checksum="FA77FA69A3CF87C9" modified="2010-08-10" version="1">MKYLKIFSVLLLVLILAATAVGIGLYKWAAQDLPDYRTISDYDPPLVTKVFTRDGDVLGQFYREKRYLVSLDEIAPVAVKAFLASEDARFYEHEGVSMLGVARAAIQNFKAGEIVQGGSTITQQVIKSLLLTPERSYTRKLKEAILAYRLENHLTKDEILTIYMNQIFLGSRAYGIEAASREYFGKHAGELNLAEASLLAALPKAPSRLNPYRNPEGARHRQMYVLSRMLNLGWIDEQEYQEAVSQPLELKRMPDPSWQKGPYYLEEVRRRLIHMFGEEKVYEGGLVVQTPTSLKHLDAAQKSLRQGLEDSTKRRGWRGPLDNIEPEMQQGFLMQQVLDPEELEKGQWTQVLVTDVEASGADVRFGDFHGRIDVSTMEWGRTPDPSRAPEEVRAIRDATRILEPGDIVWASLQHKPEPDELMDESRMEPIVFEMALEQEPEVQGAIYSLDPRTGDVMALAGGYDFHQSHFNRATQARRQTGSAFKPIVYSAALDNGYTPASIVLDAPFVYDDHETLTSWRPRNFEGVFHGPTLIRDALVKSRNLVTIRVAQNLGIDELIHRARSLGIQEEFPRDLSISLGSVPVTLEDMCQAFSAFARDGSYVVPRLITSVSDSWGQLIYENDTEPVEAISHENSYIITSLLQEVVADGTGWRARALGRPVAGKTGTTNQQKDAWYLGYSPYLLTGVYVGFDQPRPMGRFETGARAASPIWVDYRKEVEEEYPVQDFQRPPGIVTARIDAESGLLAPSGMDNTYFLPFKAGTEPTRKSARAESDREEGSGSSGATEEDLLKQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST08</accession>
    <name>D6ST08_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="9" type="ORF">Dthio_PD1163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871173.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1163"/>
    <dbReference type="EnsemblBacteria" id="EFI33824">
        <property type="protein sequence ID" value="EFI33824"/>
        <property type="gene ID" value="Dthio_PD1163"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="8">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="7">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="7">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="7">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="7">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="303" mass="33952" checksum="6184E38CCFD10044" modified="2010-08-10" version="1">MTENKDTHLFGTAALVGPPNAGKSTLMNTLVGEKVAIVTPKAQTTRNRISGILSTDRYQVVFMDTPGVNKARGKLGELLNRSAMEGLNSADVVLLVVDTELYVRKPHFLKKDFQPFKKRVSGLSGVVVVSNKIDKVRDKKKVLPVWQELSRMFPEREILPVSASTGEGTEILLERILEHMHPGPALYPEDQLSTLPMRFMVAEIIREKLFLAMRQEVPYGLAVEIEYWKEQEDLLHISAVIYVLRDAHKSMVIGRGGEVLKKVGMQARLEAEALSGKRVYLETHVKVRPGWDENPGFLRSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST66</accession>
    <name>D6ST66_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871231.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1221"/>
    <dbReference type="EnsemblBacteria" id="EFI33882">
        <property type="protein sequence ID" value="EFI33882"/>
        <property type="gene ID" value="Dthio_PD1221"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="13456" checksum="A9006E316EDF5EB9" modified="2010-08-10" version="1">MPRQKVLVARFYATTSGSMPVREWLLSLNKQDKIEIGSDIANLEFNWPAGPSQCKSLEDGIFEVRSRMTGGRTARVLFFIKEEQMVLLHGFIKKTRKTPRQELDLAKKRKKEMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST90</accession>
    <name>D6ST90_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871255.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1245"/>
    <dbReference type="EnsemblBacteria" id="EFI33906">
        <property type="protein sequence ID" value="EFI33906"/>
        <property type="gene ID" value="Dthio_PD1245"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1873899at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35091">
        <property type="entry name" value="PTHR35091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="19411" checksum="1ECBB32E91B27A61" modified="2010-08-10" version="1">MADKKNVNNVDGKEEKKKRPLWLKLILILLILGVLGAAGFFGYNYFMEQRDSEPDDPDAPEQDERPRDTVMVELEPFVVNLADPLGRRYLRTTLEVEAVNRSAANELEDQRPQVRDAILLLLSSKTFEDLRTMDRKINLRNEIVERINQVIGQNKVYKVYFTEFVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6STB4</accession>
    <name>D6STB4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1269"/>
    <dbReference type="EnsemblBacteria" id="EFI33930">
        <property type="protein sequence ID" value="EFI33930"/>
        <property type="gene ID" value="Dthio_PD1269"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="188" mass="21648" checksum="8B728827F4B9B3A9" modified="2010-08-10" version="1">MPVFSKVEIFVTVLASQIRREYYTSMSTTNIHDSTIKYFLSDRLNAISLLKSMLPEEIVKQLNFNKIYYEKDSYLPKSLQGYYSDLVVSVPTKCGSYVAKVFFLLEHKSTFKKNTPLQFLRYILEFWEQYQKNTGETVTIQGVPAIATGNRLEAYSPTVSGKAARLSRETPSTHFNNFGFITSKQMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6STD7</accession>
    <name>D6STD7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prepilin leader peptidase/N-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.4.23.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD1292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.</text>
            <dbReference type="EC" id="3.4.23.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.4.23.43" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871302.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1292"/>
    <dbReference type="MEROPS" id="A24.019"/>
    <dbReference type="EnsemblBacteria" id="EFI33953">
        <property type="protein sequence ID" value="EFI33953"/>
        <property type="gene ID" value="Dthio_PD1292"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2046608at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DiS_P_DiS" evidence="12">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="11">
        <location>
            <begin position="106"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="27847" checksum="5A1D44B20B00E526" modified="2010-08-10" version="1">MEFESFFPVLALIVGLCLGSFYNVCIHRYVTGQSIVLPGSHCPGCGHILSWWENIPLISYVLLLGRCRSCRQGISPVYPVVESLSGILALFLALKFGFGLEWLAYMLFFGLLIVASFIDLKIYILPDIITLPGALLAFGASFILPVFWLDALLGALLGAGLFWSLQWAYRTFKKVEGLGTGDIKLMLMLGALVGWQGLPIQIFAAALTGLAASLIYMKKTPGGGMQTPIPFGPFLALGAVIYILAGENIWTWYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STE4</accession>
    <name>D6STE4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871309.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1299"/>
    <dbReference type="EnsemblBacteria" id="EFI33960">
        <property type="protein sequence ID" value="EFI33960"/>
        <property type="gene ID" value="Dthio_PD1299"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZXYT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1983302at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="157" mass="17714" checksum="0C9C144E694A86CE" modified="2010-08-10" version="1">MNQDAIPNENASVEPDLFPPGSRACFIFTHEKGLTEKLVTIFESQGYYTATADDPGQGVAKLRLNRYDVAVVQHNSSNASMFEEINSWPGNTRRAMNLIVLGGEAPSMHQSQSLVLGANFYLNIDDSDNLEELIMQCLRGYQLYYHPWHKVLEEMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6STJ0</accession>
    <name>D6STJ0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="10" type="ORF">Dthio_PD1345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871355.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1345"/>
    <dbReference type="EnsemblBacteria" id="EFI34006">
        <property type="protein sequence ID" value="EFI34006"/>
        <property type="gene ID" value="Dthio_PD1345"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="465" mass="51978" checksum="DC91E46EADA21EA2" modified="2010-08-10" version="1">MFDSLSERLNSVFKKLKGHGRLDEQNIQAGMREVRLALLEADVNYKVVKDFTQRVKERALGQEVLKSLTPGQQVVKIVKEELEELLGGEQQGLDLKAKPPVVIMMVGLQGSGKTTSAGKLALHLKGLKYSPYLVPADVYRPAAIDQLHKLAGDLNMPAYPSTSSDNPVDICMRALEEARQKAYTAVIFDTAGRLHIDETLMQELVSIKEKCSPHEILFVADAMTGQDAVTVAQRFNDLLDITGVVLTKMEGDARGGAALSIKSITNKPIKFVGTGEKLTDLEVFHPDRVASRILGMGDVLTLIEKAQEDMDQDEARAMQEKFQKSKFDLDDFRKQMGRLKKMGSIEGLLKMIPGMGKMRDKLKNVQMPEKEMGKMDAMINSMTRQERSNPKIFNASRKQRVARGSGTTVQDVNQLLTNFDQMQKMMKKMVGKDGQPQLDMNSQGMPVPGRTKTKRKKVKRRKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6STK8</accession>
    <name>D6STK8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1363"/>
    <dbReference type="EnsemblBacteria" id="EFI34024">
        <property type="protein sequence ID" value="EFI34024"/>
        <property type="gene ID" value="Dthio_PD1363"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="190"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="379" mass="43388" checksum="FE245098611FA94F" modified="2010-08-10" version="1">MKILYLTHSQIPSTSANSIQVMNMCQAFHASHSVSLFARRTEYYPGHQNIFSYYGISEKFELLLPQNKSCGSISSLYSYWFLLHLLKRRKFDICFGRHLKYLAIAGFFGMPIIYEAHEMPKKIKEMFWLKRVLSSDSFKGLVCISGVLREKYLRLFPGLSENKVLVAHDGINLEFYDSIASLKDQLPGQNTYNVGYVGGLKPEKGIQLIIETAGILKNADFHLVGGSPAEIDYWEQQCPNMFNIFFHGPVTPEKAVQYQKSFDVLLAPYQKKSWTSRDGKLMVEDSPERVIGNSPLKFFEYMSAEKPILASDIPVAREVFTQGVDALLSDNSPEQWAEWIQVLMQDRNFAASLAQNARQKVHGFTWKKRSQKILSRFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6STN3</accession>
    <name>D6STN3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bioB</name>
        <name evidence="16" type="ORF">Dthio_PD1388</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871398.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1388"/>
    <dbReference type="EnsemblBacteria" id="EFI34049">
        <property type="protein sequence ID" value="EFI34049"/>
        <property type="gene ID" value="Dthio_PD1388"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="47"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="322" mass="35354" checksum="6922FAAB9D9E98D3" modified="2010-08-10" version="1">MQYFLDLALKTAQGNMLADSEQKTLLELPYEETHRLFPGAELLRRNFCANKIRVCAITNAKSGKCSEDCAFCAQSAHHNTSINSYPLKNPGQMSLEGRNMSAQGVNRFSLVTSGKGLEAEEVQQVCRVTRELASQGISPCASLGVLKQQELQELKDAGLTRYHHNLETAPGFFPSICTTHDYSQRTETVRLARQTGLSVCSGAVFGLGESDAHVLELALTLRELDVDAVPVNFLVPIPGTPLENNDQLTPLRCLKIICMLRYMLPRHEIIVCGGRLENLGELHPLIFMAGASGLMTGNYLTRQGRGVAEDMQMITDMGLEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6STS0</accession>
    <name>D6STS0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1426"/>
    <dbReference type="EnsemblBacteria" id="EFI34086">
        <property type="protein sequence ID" value="EFI34086"/>
        <property type="gene ID" value="Dthio_PD1426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10180" checksum="539F7E5A482B368C" modified="2010-08-10" version="1">MKDYINLAQLKRRGWTIKLIADFKPEHDSEADNPINPAWAPQKLYDLDKIKAIEATPEFQGRKKWANWFQGHMKELARQRKEARST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STU7</accession>
    <name>D6STU7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871462.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1454"/>
    <dbReference type="EnsemblBacteria" id="EFI34113">
        <property type="protein sequence ID" value="EFI34113"/>
        <property type="gene ID" value="Dthio_PD1454"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033JMW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2096762at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13242" checksum="D626A682DDA42DF1" modified="2010-08-10" version="1">MGSQVIAACKCGANAIILIGGGMLNFMETCYFPCMCKGCHEVVQVNLLAKETRCPECRARNPIPYDDPGLQGTPGHHHVVEWRMTDQLDRDLVLTDGKYMCPKCGKMSLEFRDSGLCWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6STX0</accession>
    <name>D6STX0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS116/IS110/IS902 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871485.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34136">
        <property type="protein sequence ID" value="EFI34136"/>
        <property type="gene ID" value="Dthio_PD1478"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="10"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="353" mass="39854" checksum="DBF9A5648B86D552" modified="2010-08-10" version="1">MSTNVANFTIGVDLGDRQNVVCVLDASGEVVKIFKVSNTKKAMHKSFEKYSGSLVAIETGTHSGWVSRLLEELGCEVLVGNTRKLRAIWQDPVKTDYRDAEMLARIARVDPKLLEPIQHRSEQSQEDLVLIQSRDMLVKSRSSLINHVRGIVKSFGERIPSCSAPSFHKKAYEHVPERLKFALFPLIEQIESLTKRIREYEQKIAEVSQKSYPETDVLRQVPGVGPITALAFILTLEDSSRFHKSRDVGPFLGMVPKRDQSGDMDKQLRITKCGNKDLRRLLINAAHYILGPFGPDSELKRHGERISQRGGKISKKRAIVAVARKLAVLLHRLWVTGEEYDPFYNQSVVRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU06</accession>
    <name>D6SU06_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871789.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0412"/>
    <dbReference type="EnsemblBacteria" id="EFI33097">
        <property type="protein sequence ID" value="EFI33097"/>
        <property type="gene ID" value="Dthio_PD0412"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065826at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10468" checksum="2B9784F76B2BA4E8" modified="2010-08-10" version="1">MQITQRSEYEKLVLQEIKDLPESEIQKIIKMIQFLKKEVLQHDKPEDEDYLEFWDSFGSWKDERTAEEIIKDIYETRRSSSRDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU10</accession>
    <name>D6SU10_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871793.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0416"/>
    <dbReference type="EnsemblBacteria" id="EFI33101">
        <property type="protein sequence ID" value="EFI33101"/>
        <property type="gene ID" value="Dthio_PD0416"/>
    </dbReference>
    <dbReference type="OrthoDB" id="971625at1224"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8530" checksum="ACA6DE36291B956C" modified="2010-08-10" version="1">MSIQYIVNESGVPTAVVVSIEEWEMLLDKVRKMEPERDDTEYLLQSETMKKRLLEARSRSGGKSWEEVQDALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU57</accession>
    <name>D6SU57_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871533.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0144"/>
    <dbReference type="EnsemblBacteria" id="EFI32837">
        <property type="protein sequence ID" value="EFI32837"/>
        <property type="gene ID" value="Dthio_PD0144"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="384" mass="43739" checksum="64D2E7BE50366E5B" modified="2010-08-10" version="1">MNSEPAKPLQPYVADKKILVTQPFLPPLEEAQEFLQDIWDSKWLTNQGRYHQALEKELASFLGVPYVALFANGTLALFTALQAMRVTGEVITTPFSFVATTHALWWNNIRPVFVDIEPEHCNLDPEKVESAITPKTTGILPVHVYGHPCQVERLQEIADIYGLHLIYDAAHAFGVKYKDQSVLNYGDLSILSFHATKVFNTFEGGAIICHDAKTKKRIDYLKNFGFVGETTVIAPGINAKMNEFQAGIGLLQLKYFDQVVEQRKAITKRYQELLSDIEGISFIHQDPDVTYNHAYFPIFIDQEKCGRCRDDIYEKLKAHNYFGRRYFYPLISTFNAYKSLPSAEPENLPVATRKANQVICLPIYPGLEMEHVENIAALIREFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU59</accession>
    <name>D6SU59_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871535.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0146"/>
    <dbReference type="EnsemblBacteria" id="EFI32839">
        <property type="protein sequence ID" value="EFI32839"/>
        <property type="gene ID" value="Dthio_PD0146"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="388" mass="44959" checksum="69FE7D025636C948" modified="2010-08-10" version="1">MISEPAKSLQPHVADEKILVTRPFMPPLEEFTRGLREIWDNQWLTNNGPVLQRYTRKLTRYFQNDNLSLFNNGTLALQIGLQGMNITGEVITTPFTFVATTHALYWNKIRPVFVDIEPDYYTLDPQKVEQAITPWTKAILAVHVFGYPCKYRALADIARRYNLALIYDAAHAFGVRVNGKPIGNLGDLSMFSFHATKLYHSLEGGMLLYKDQGLKQKFDYLRNLGFKSETRVDMPGTNARMNEIQALMGEQVLEYLDEIISRRKKLYELYRQELEQVPGIGFSPELPGDVQASYAYVPVRVDEKSFGMSRDDLYTRLKKYNVFTRRYFYPLICDFACYRHLSMTDPLTTARRVADQILTLPIYDKLEEEDVVRICEIIKHIQKNTDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUA3</accession>
    <name>D6SUA3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871576.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0197"/>
    <dbReference type="EnsemblBacteria" id="EFI32883">
        <property type="protein sequence ID" value="EFI32883"/>
        <property type="gene ID" value="Dthio_PD0197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029465">
        <property type="entry name" value="ATPgrasp_TupA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14305">
        <property type="entry name" value="ATPgrasp_TupA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="908" mass="103062" checksum="34E722AD3141275B" modified="2010-08-10" version="1">MFNESPSAGRGHDPEELLAQARQALDNEDWSTAVKVLNSILLRHKKNTPHEAYILLSRALRGQDKLDRAEKIIQQGLTGYPDSISMLTEYADIARIREDWAETKARLDVLKQKIDALKAASARASTPQPSPSSEPEAQHQEQHQPQTEPEISARTRTKKIMWLSPMCALDRRSGAACQMRSVLCTLAGAGWDAYAVNMTLCDGQEEYPVGSIIGDKRAVPENYGKVFKIKRDGVKHNIFYTRSSYGKNLTKEEARDFFQHAKRALEQIKPDVVLTYGSSSLCKELIKVARKNCTTLIFYLANPSYDDPELFRPFDQVLVPSQFQSDYYQQKIGIKSSVLRTMIPEGSQISPQEVLSTQAPQMRRKGFITMINPSMAKGATLFARLVSTALRERPDLLFLAVESRMSSDQWAEAGIDLAGMKNIWWIPNQEDVRTIYARTSILLFPSFWNEASGRSIAEAQLGGIPVLASNHAGMPEQLNGGGFLFDIPEKYRQKYSRVPSEAEVRPWLDTIYRLMDDDEFYRDSTRRALECGAMFHRDVMQKDIIQRFESFADGENLLPPLEPGQKTPAHTPVQRGEKLSRNAPCPCGSGKKAKKCCGVETDHQGKATGAEQKAPRQQLDPPTPDQIVNSSANRRPEPEEISREMQEIKEALGYNPDLTAPVTFNEKMARRRLLGEVTDAETLQDRWQVRRWVQDRADESVLPEVYQAVSSADQISWDELPESFAIKTSFNNQVRLIPDKSRINPRDVEKLCRQWLNGHAKTDGETPGRAVQPVVMFTGLYLDSHAMLPRSYGFFVFHGQCRFIQVDHPFPEPKRTLYSPDWEILPLCLDLPQGPVQDKPENLQEMIDLAQKLGQGYDFMRVDLYSVQGRVFFEAVDLFPGEARQRFFRPRDPDSTYEPDQWAGAFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUF0</accession>
    <name>D6SUF0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0244"/>
    <dbReference type="EnsemblBacteria" id="EFI32930">
        <property type="protein sequence ID" value="EFI32930"/>
        <property type="gene ID" value="Dthio_PD0244"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1301886at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="232" mass="27374" checksum="F14D1A6D258A0DA7" modified="2010-08-10" version="1">MQQVNTTRIQVEEISAQVDFKAVKNLNLRIKAPGAHVYITAPRGADIRQVRDFLISRLEWVRRTRSRILNAASDSPAFPQSGAVYSIWGWQYTLLLVERERPASVKLRRRSMIMSVRPGTGPEKRQALLEKWFREQVKHAARELVDKWSRIMRVQVNKIFVQSMKTKWGSCNMVHGNIRLNTDLVHHQPECLEYLVIHELVHLLESNHNERFYAIMDKFYPHWRKYRTMLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUF4</accession>
    <name>D6SUF4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871627.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0248"/>
    <dbReference type="EnsemblBacteria" id="EFI32934">
        <property type="protein sequence ID" value="EFI32934"/>
        <property type="gene ID" value="Dthio_PD0248"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088213" evidence="9">
        <location>
            <begin position="31"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="759"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="833" mass="92719" checksum="BA0316134054DF8E" modified="2010-08-10" version="1">MQRCTKLSGLIFSIVLAVFFLFLQPFSACAQSNTAASPSGDVSRAGVERLLQDLEDPQKLEELKEDLKILLAAQETREEDKPYEPLADAEGLLGQLLILMSGHMQEINRVLTDAGQSTLELPEIARDLVQQSRDPETLRTWGEMGGKVALVLVAGFLAFWLAKRLLRRPLKSLEDQEAYSRATRAAFLLGSTLLEIVPIIAFAAVAYAVLPLLDPADGTQVVALTAVNAIAFAKLVLALARLILVPGAPALRLFDIENETAKYLYIWVRRIVSLAIYGYFILEASLLLGLPASLYVSLQKLLGLIITLMAIILVLQNRSCVAEWLRGDPVQEDQDQSAQSQLTEAMRRRMQALAAFRRRLASFWHVLAIVIILGLFGTWALQIEGGLFFLARALVLTGIIILITTFILRLNDRGQDYLFRISDDLKAGHPELEARANRYLPLLKKTIRAVIYVLAVFSILNAWGLGTLGWLMSPQGFAIISQVVTILVILMIASLIWEFAAIRIEKSMALESESEDKRATSRKLTLLPLLKNVIMIAVILVAGMSVMAHLGINIAPLLAGAGVIGLAIGFGAQTLVRDVITGAFILLEDSMAVGDWVEAGGHAGTVEHLTVRTVSLRDLAGTLQVIPFGEVTTVQNYNRDYGYAMIDAGVAFRENYGEVVHALQDVAAELKEDETWGPDIIGDLEIFGLNKITDSAVEVRVRIKTRPLCHFAIRRAFLERMKRVFEERGIEIPFKHHTIWFGEDKQGDSRPMRVVHEARKSLPEKTEAYQPEPDQLPERKIEYVTESDASKEVVKDKEEAEEGKEEEERRRQEQEQKENKGPEEKDSEDSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUH7</accession>
    <name>D6SUH7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ORF">Dthio_PD0271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871650.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0271"/>
    <dbReference type="EnsemblBacteria" id="EFI32957">
        <property type="protein sequence ID" value="EFI32957"/>
        <property type="gene ID" value="Dthio_PD0271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="109"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="319"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="111"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="462" mass="50248" checksum="32DA85B01248B1D0" modified="2010-08-10" version="1">MNIGLGEAARAMQGTADLQGLENAPVNAVRTDSRQTGPGDLFFCLQGTRSDGHSFAGQAADRGALAIVAHRDLGSIQNTPVLAVDDTLKALGRLGRHWRLKAGPRVLGITGSAGKTTTKEILAEVLKTRFTVGKNHKNWNNQLGLPLSLLMQKGDEDFWIMELGINNTTDMDELGEILLPDAALILNVGPCHLEGLGDVSGVARAKARLLDYLRAEHRAFINLDYPDLKREAGARPDLNTTWFSSRDPEADCRVSHSRDNLFVLNLNEEEIPFHAPVQGAHFCENLAAIWAVALEYGMQPDEIQAGLEKSSLPEQRMCISRSGDWTIIDDSYNANPMSMQAALETARSLASGGDLVLVLGDMAELGRDEARAHRDLGRSLCAGAFTALFYNGDNLEHVLSGMNGEGSRKAHKIKDVSSFLSAHDKLGCRHGVILFKGSRRAGMENFVQAFKARVEKNREAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUK9</accession>
    <name>D6SUK9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">Dthio_PD0303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871682.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0303"/>
    <dbReference type="EnsemblBacteria" id="EFI32989">
        <property type="protein sequence ID" value="EFI32989"/>
        <property type="gene ID" value="Dthio_PD0303"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI32989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="208" mass="24150" checksum="0D45A9B0D972E8DB" modified="2010-08-10" version="1">MARYTDSKCRLCRREGTKLLLKGDRCYTDKCAYERRAYPPGEHGRARKKSSDYALQLREKQKVRRMYGLLEGQFKRYFEIADSRKGATGTNLLVMLERRLDNVVYRMGFANSRSQARQLVRHGHFHINGTRVNVPSILLKEGDVIGVIEKSRKMPVIQDARDVLARRGSPDWLEINDQEFKGTVKTLPAREDITFPINEQLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUR3</accession>
    <name>D6SUR3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">Dthio_PD0357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871736.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0357"/>
    <dbReference type="EnsemblBacteria" id="EFI33043">
        <property type="protein sequence ID" value="EFI33043"/>
        <property type="gene ID" value="Dthio_PD0357"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="8349" checksum="3CFF1CDC360F3EE0" modified="2010-08-10" version="1">MAKEESIEVEGVVEEALPNAMFRIKLDNGHEVLGHISGKMRKFYIRILPGDRVKVELSPYDLTRGRITYRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUU7</accession>
    <name>D6SUU7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0391"/>
    <dbReference type="EnsemblBacteria" id="EFI33077">
        <property type="protein sequence ID" value="EFI33077"/>
        <property type="gene ID" value="Dthio_PD0391"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032UQM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="515" mass="58494" checksum="F1D50A887BD50251" modified="2010-08-10" version="1">MSRTDKAPAMPTRDLLVILGLTSVYLVVELAFNASLLDVMGTSVSSTELDRIEHVGRILCGIAVFLFVYGTLLLPTMNKKRIGGFVGKVIVFASFGPLIIWGAYVGQERLVESIVKNSDPEWRKQAVHLRVVQSSLLEDRAELSGIELSREDLGTPEGKSFIALLPFYGSGLSRTDILSSENIDALLRQRVREEMGTRNEFLDEVRPKIGDLENAYNEYADASERYYESLAPGMADKRAQEKWEEYVRRLESETGRKPNNVPRRAESHVREKVQGMGVPVSNSWKPYDRNGFISAFKRNYDSVVKNRFDSEVRRRVGGSVNPGLSWDEFIREPAVVSYMRSRSDIIKQYGFPDKLTNEGFLQQYYEPVKRKKMEEYGSLLRAEAEFFADGKKYAQEGRKALYAVVVPPLALFFSVTGALLHVVKTANFAFRLVRIHTLIRWAVWICVLGGTLAFVNTQSLPNKVTESELFETLDKSLASKYGRTTASAMKWTVEFQPYFYPRNKAIESRLNLIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUV9</accession>
    <name>D6SUV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0404"/>
    <dbReference type="EnsemblBacteria" id="EFI33089">
        <property type="protein sequence ID" value="EFI33089"/>
        <property type="gene ID" value="Dthio_PD0404"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="16535" checksum="FA74F957ED3B3F8B" modified="2010-08-10" version="1">MSQSKIIIIAGPNGAGKTTFAQEFLPGEANCLTFINSDLIAAGLAPFNPERAAFKAGRLMLEEIFENVRKSRSFSFETTLSGSSYSRHIPEWRSAGYKVKLFYLRLATPELAIVRVRNRVIMGGHDVPEQLSAGDLSGAGKILRIYTRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUW0</accession>
    <name>D6SUW0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871782.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0405"/>
    <dbReference type="EnsemblBacteria" id="EFI33090">
        <property type="protein sequence ID" value="EFI33090"/>
        <property type="gene ID" value="Dthio_PD0405"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033NJC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="64" mass="7354" checksum="3679BEA1227EC3B1" modified="2010-08-10" version="1">MEITHDKMKPKKKRDMDMINAEAALIRAARRARERAWSAGIGVVYLKDGRIVEEMSDGTIKYCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV47</accession>
    <name>D6SV47_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871885.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0102"/>
    <dbReference type="EnsemblBacteria" id="EFI32803">
        <property type="protein sequence ID" value="EFI32803"/>
        <property type="gene ID" value="Dthio_PD0102"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="205"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="411" mass="46869" checksum="57824594DF2D1C37" modified="2010-08-10" version="1">MDRKRDLEDKIAALLKLFPAVAVIGARQCGKSTLARKLLPDWRYYDLENPNDYQLISSDPVAFFSINSGRVIIHEAQQYPELFRVLRGVIDADRNRKGRFLLTGSSSPEIGKGITESLAGRIATVEMWPFKQGELFQRPLSPLYDAIVSNRGMQALTDLSSTVTPEQSARVWLRGGFPEPAIHAAADHAYYKLWMDNYIRDYIARDIRSLFPRLNINNFRRFLLLLAQFSGHQLNMSEMARSLEVSVSTIKDYLDIIHQTFVWRNLPPYEKNSLKKIQKAAKGFFRDQGILHYLLRIADLDALLLHPVAGHSFESFVTEEIIRGLHCTMETGLEFFYYRTVDKSEVDLVVEGFFGLLPIEIKLNSALKQQDLRGLKNFIHDTGAPFGIVVNRAASIQQPAENIVQIPVHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJQ3</accession>
    <name>D6SJQ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PglZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869231.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3558"/>
    <dbReference type="EnsemblBacteria" id="EFI36106">
        <property type="protein sequence ID" value="EFI36106"/>
        <property type="gene ID" value="Dthio_PD3558"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8Y8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="375588at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="790" mass="89379" checksum="988817B0947286FF" modified="2010-08-10" version="1">MRVIDHILRSIRDAALYNPEVQAAPSCILWPDWDRQWEPAVNRLLQEMPELFVLGKYSPEQRTGPAIWLRCVILFSSANVEQVCDAPVSESLNSQFPVVHSGATPVIYLPGVSRQDLRAVESCPDSLKPLAELQYRGVIWSQVNAKDWTILAFLKSDQGGLGLDVARDSETKRAIRTALMPLLDEDVDLLECKRLDKDYFHNLLSGGDPVRDLLQWISAPDDFRNRLDKNHWEAFVQVCKSQFGFDPQKQGVLTAAHNLAQQKNQWRSVWSRYREAPHRYPGIPGQIRKCRPPAGSLMWYVGGEFPGWPQWNEQQEKNLRENLSGLKELPAHNARQEIIELEKIHASRRNYVWAELGLSPLAMSLKHLAVMAEVTRNTLAAGTLSDLAAGYSDWGWEADDALLRALACVHRQEDFEALSSALRTVYLPWSQESSRHLQRLWLKEHSVSHVQEEQEVYFECCLFVDGLRFDCARRLQTLLEEKGISVSRQLGWAALPSVTATGKPAASPVAGHISAAQASQENFEPCTAHHFKKLLQENQWTVCRQNDPLPRISELEVKKLWVEFGDIDHEGHEWGWKLSAHVDRLLREVRDRIEDLIQAGWTAIRVVTDHGWLLLPGGLPKIELPRALTQTKWSRCAVIKSGADTDENLYPWYWNPDRHFALADGISCFRRNDEYSHGGLSLQECLLLKLTVFAGPAARAEESLQLMDVVWKGLRCTVVVEGWTQDLWLDVRTSPGEASSSLVLKLKLLKKDGSASVVVEDEQFEGQEAHIVLINAEGQLISQTSTIIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJR5</accession>
    <name>D6SJR5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869243.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3570"/>
    <dbReference type="EnsemblBacteria" id="EFI36118">
        <property type="protein sequence ID" value="EFI36118"/>
        <property type="gene ID" value="Dthio_PD3570"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10703" checksum="FBF6DF1CE309787A" modified="2010-08-10" version="1">MQEYIVRRPLKRAPVHPGELLREDVLKNLGLSVSEAARRLNVSRQQLHRILACTHPVTTEMALRIGRFAGNGPWIWLRTQQAYDPWNENSTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJS6</accession>
    <name>D6SJS6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869254.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36129">
        <property type="protein sequence ID" value="EFI36129"/>
        <property type="gene ID" value="Dthio_PD3582"/>
    </dbReference>
    <dbReference type="OrthoDB" id="91950at68525"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025961">
        <property type="entry name" value="Metal_resist"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13801">
        <property type="entry name" value="Metal_resist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088082" evidence="2">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="155" mass="17551" checksum="22CE440108F04CAB" modified="2010-08-10" version="1">MSGKVYTGFAVALLAVLLLASAAMAQQQGRWSDEARPGAAWSQLDEEQQQELWEQRKAYQEKVYPVRQMKKARNAELNAELASQDPDQGRIEELKSELIQLNQELFETRLEHRIEHRQEYGACPGMRGELRSQGPRDRGDRGQGARGQGGQGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJU1</accession>
    <name>D6SJU1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869269.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3598"/>
    <dbReference type="EnsemblBacteria" id="EFI36144">
        <property type="protein sequence ID" value="EFI36144"/>
        <property type="gene ID" value="Dthio_PD3598"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="9679" checksum="65A983866C813AD9" modified="2010-08-10" version="1">MNKKQMVDSLAQKSGMTKADAQKALDGVEDIISEQLKNGDQVALPGFGTFTVAERKPRTGRNPQTGAEINIPAARVPKFKPGKKLKEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJX9</accession>
    <name>D6SJX9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36182">
        <property type="protein sequence ID" value="EFI36182"/>
        <property type="gene ID" value="Dthio_PD3638"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033MTI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="208" mass="22669" checksum="7BFF3279A53EFF1E" modified="2010-08-10" version="1">MKAVVYLILILAFLLVTDVVGGQSTIYCYKTSVGTTIFSDSPCTDESPEAKTQGQLTIPDSQNILESRPILEQRSRTQGHTGKLTSEDTTSRPYQLVFSEPSFSDLLDGYIVAQDGTFLGKISTSTMDSQSILNSVGAHGSTVRRDSIFNSVGKFGSSVSRYSAFNDMASSPPKVYARDGNFIGYLTTNTMRSPSIDPYSLIGWLRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK06</accession>
    <name>D6SK06_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869331.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3666"/>
    <dbReference type="EnsemblBacteria" id="EFI36209">
        <property type="protein sequence ID" value="EFI36209"/>
        <property type="gene ID" value="Dthio_PD3666"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042518">
        <property type="entry name" value="SirC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sirohm_synth_M" evidence="7">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="222" mass="24445" checksum="7BABD1616F8E93AA" modified="2010-08-10" version="1">MRYFPVFLDLESKTCLVVGAGPVGRRKISTLIKSCAGTIIVIDPGAKNHPLLEDESIQLVNRPFKPGDVDGCHLVFACTSDHEINQQVTRACRRKNIWCNTATDPDQGDLVLPAVLERGDLILAVSTCGASPALSARIKKELASRYGPEYASLTTLMSRVRKHVLPMGLPQEKNQRIFHAILDSNAAELLKKGDRQGLHRLLQSLLPSGAHNHIQEMIHALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK47</accession>
    <name>D6SK47_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869372.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3707"/>
    <dbReference type="EnsemblBacteria" id="EFI36250">
        <property type="protein sequence ID" value="EFI36250"/>
        <property type="gene ID" value="Dthio_PD3707"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033GEX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2085932at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15078" checksum="52C2AA33F60E29CC" modified="2010-08-10" version="1">MLQQSAPATRPGLEEVKRQFEHWRETRHTRSPIPNHLWASAVSLAQDYSICKIAKVLHLNHSHLKKRVLAVQAQESLQPGPSFVEFELTSSLPCTEYHLETEARDGSKLKMQLKGPDLPNPLEILSAFWSKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK86</accession>
    <name>D6SK86_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="4">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="4">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sucD</name>
        <name evidence="10" type="ORF">Dthio_PD3752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869408.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3752"/>
    <dbReference type="EnsemblBacteria" id="EFI36289">
        <property type="protein sequence ID" value="EFI36289"/>
        <property type="gene ID" value="Dthio_PD3752"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="9"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="4">
        <location>
            <begin position="420"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="4">
        <location>
            <begin position="499"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="651"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI36289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="692" mass="74667" checksum="582D52E64BE0FBF5" modified="2010-08-10" version="1">MKLNEHMSKELLKGAGILVPRGEMIGPGDIRDFAPEFEFPWVVKAMVLTGGRGKAGGVRVVQNREEFETAARQILGMQIKGESVPFVRVEPASHIQREMYLSMTLDRQQKSLVLTAGRTGGVDIESSGRDNILSLTLDPGLGLHDFQIRRVFFHLDLDKSMFRSFSGLLKNLYTAFTRNRLLLAEINPLVLTGGQELTALDGKVELDDNYVQINRGLLGYHVPEHLGEQERLAGEAGLSYHRLDGRVGMVVNGAGLAMATMDLLNFSGVPAANFLDLGGGADQERISRALDILFNDPGVELVFINIFGGILSCEKVALALAAALEEASVARPMVVRFSGFKAREAGRIIQGLNADNIYYVQDLARALEALKELSSSPGGGQKFQRIEFPPAQEKKRTPKKNEPAPFPLNKNTPVLVQGITGREGMLHAREMQNFGTRIVAGVTPFKGGSHVEGVPVFDSVHKACMEHDIQASVIFVPGAAAADAVMEAVDMHIPWVVCITEGIPQQDMMRLLPAIRRSGTRLVGPNTPGIMVPGQTKLGIMPASIFSRGPVAILSRSGTLTYECVQSLTSAGMGQCMCLGVGGDPYVGLDFRDIFPLLQRDPACRAVLVLGEIGGTAEEDLARELDEMGFDKPVLGFVAGQTAPPGKRLGHAGAILDEHSGGIRAKLQVMHECGITICPDLASIPAMVEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKB8</accession>
    <name>D6SKB8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869440.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3787"/>
    <dbReference type="EnsemblBacteria" id="EFI36321">
        <property type="protein sequence ID" value="EFI36321"/>
        <property type="gene ID" value="Dthio_PD3787"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2117613at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="18160" checksum="985FF14C45477CBC" modified="2010-08-10" version="1">MAISRTVITGGNSVCIVLMALLFLQPFIVNADDSKPIEWREAFVTVDVDIREIEGHKDHAVGLMQQRGFAFYEDEEVATVSTWLTFERSGAKTNYRGYAIYAFPDGATKIGSFIGTGDPRGEQAGQFTLEGGTGRYEGITGQGSFSGQGFPPHGDIYLDVSGTYSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKC9</accession>
    <name>D6SKC9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical cytosolic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869451.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3798"/>
    <dbReference type="EnsemblBacteria" id="EFI36332">
        <property type="protein sequence ID" value="EFI36332"/>
        <property type="gene ID" value="Dthio_PD3798"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025587">
        <property type="entry name" value="DUF4351"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14261">
        <property type="entry name" value="DUF4351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4351" evidence="1">
        <location>
            <begin position="260"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="37177" checksum="5E47DBAFD8054820" modified="2010-08-10" version="1">MNPLRELPGIWFTKLNKEFYFPGIFADIDWSSGYDFLDKELQQVTKDAELGRRYVDKLVRVRRLSGDEGWVCVHIEVQGEAEDVFARRMFTYHYRLFDQYDKPLASLAVLADTSPGWHPDSFGYELYGCRMRFDFPAVKLLDWESEIDQLLESDNAFALVTAAHLLTKKTQGKPEERYAAKIRLIRILFARGWDRQRILDLFKVLDWLMSLPEDLESKIFSDIRQIEEEYQMPYVTSIERIALKKGMQEGIEKGMQQGMQQGMQKGEAQLLLRQLALKFGPIPEDKQRLIESADSQKLRQWSERILTAQSMDEVLNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKH5</accession>
    <name>D6SKH5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP dicarboxylate transporter, DctP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869494.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3850"/>
    <dbReference type="EnsemblBacteria" id="EFI36378">
        <property type="protein sequence ID" value="EFI36378"/>
        <property type="gene ID" value="Dthio_PD3850"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00787">
        <property type="entry name" value="dctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088216" evidence="2">
        <location>
            <begin position="23"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="37657" checksum="3F7AB325DCB81F01" modified="2010-08-10" version="1">MKKLVLTLAALALLLGVSPAKAEYQSMTIRAATANPEGSLHTTAINKFKEIVERESDGKIDVRTFYGGSMGDEQANVRQLRNQEIHLSVLAVGNLTPFAEQATIYYLPYMFPEIEKAYTLLEHEEFNAEIADKIATQSGTRPLSWLVGGYRHLTNSRHPVTTIEDLQGLRIRTPPVTIQLESFRSWGVEPHPLAWTETFSALQQGVIDGQENPHAVNRDQKFWEVQDYITELHYLLWVGPMLVSERWYQGLDPATKDLVTRAAAEAAAYEWEWAAEQDQIALQECLDHGMELHQLEDEEIWMEKARALWPRFHDRVGGEEVINEALSIMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKI1</accession>
    <name>D6SKI1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2597"/>
    <dbReference type="EnsemblBacteria" id="EFI35192">
        <property type="protein sequence ID" value="EFI35192"/>
        <property type="gene ID" value="Dthio_PD2597"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="8"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="332" mass="38821" checksum="0F4729DCAFA55317" modified="2010-08-10" version="1">MSDTSKYHDHTFRAILGREPVARDFVRYHLPEEITRDMNLDTVKVSSRSYVSDNLKESMTDIVITLQLNTGEPAEIYILVEHKSDLDAWTKIQLFKYMNEVWQSFIQKQTGTLPIIVPLVFYHGTGRWNYSLEFSDLFNLPSEHYRKYIPKFEHILHEVPEINKKKVKSSITLEVFHLVLEYIFYPDKRGKIYEALELLFKGLDAKEAHEIFAILIKYLLIATDETPEEAEEKVKHLPKGGETVKTTAEVLRQEGYHEAIKEKPMWKKEGELKNAQETLIDISTEQYGPLPDMLYEKIKSIQSLENLRALNRKVIRTQSLEEFTELVNRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKN6</accession>
    <name>D6SKN6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II and III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2658"/>
    <dbReference type="EnsemblBacteria" id="EFI35247">
        <property type="protein sequence ID" value="EFI35247"/>
        <property type="gene ID" value="Dthio_PD2658"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="553" mass="61228" checksum="43E1B080CF4CAFB6" modified="2010-08-10" version="1">MRLLRIFAPVSRGFFSGFSGAGTFLLIFTMLIISACSSGREPPEESGYAALNRQMAEEQRHLQEARIQQEQQLEHSPSPRDRHEEVGPLIPEFDPLQESIVSISVNNKPLHDILFVVARNAGLNLVVSPEVSLDKRITISFDKTPASIVVDRLLDSYDLYWSVEDNVLAVRPFEEKVFKLDFLDSNTRVAIDSGGNIFGERSGDRRTGTDDLYVGSHNLKGNFAMQSTFGGEDDGNSIYGFLQKNLNDILMDATGERQGHFVLDPTAGSLYVRASPSKMRVANNFIKQLKSKLSQQVVIDAQILEVSLSDSFQLGVDWSYISQELASNFAYSVNLGWQSAQGFGTYGLESEDPVPIVIDSRTGDVDEVYRQFSATIQALETFGQVSVVSNPHVRSRHLQPALVTSGTTRNFIQEITRSRRATDEDWVDYSVNTGTAFEGVMLGVVPFITDNGDVDLDIFPITSQVDLSETAKIGGDQITLPKVNVRNVNTKVRVNDGDTVILGGLIQKGSRERERATPGASRIPGLGWLFKQREDSQDLSELVVIMHVRVVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKN8</accession>
    <name>D6SKN8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2660"/>
    <dbReference type="EnsemblBacteria" id="EFI35249">
        <property type="protein sequence ID" value="EFI35249"/>
        <property type="gene ID" value="Dthio_PD2660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="58" mass="6422" checksum="80679CBF678B701D" modified="2010-08-10" version="1">MTVHTGFDSDFDPDTDTDPDPDDKLKHKQLSGQGATFSLGLRAWPELVTIRKFLISGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKY0</accession>
    <name>D6SKY0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2756"/>
    <dbReference type="EnsemblBacteria" id="EFI35341">
        <property type="protein sequence ID" value="EFI35341"/>
        <property type="gene ID" value="Dthio_PD2756"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z90U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="885802at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="374" mass="42828" checksum="76076092D6D8654F" modified="2010-08-10" version="1">MNSMPLDITSLKNQVQLNCHISDANYSGTFSLCMLLLRLRNLYKWEVDMPPWQEPHQGDLLQWVEDRENMWLDLEGRSPEPLMVEGENLDSLEPSQVNALLAGSDLHYGAGLVTGMKPSYFLGRVARKHEQEGMTVCIVDQELARDIFSVPLMRQGNLIIGRRRSMATLLWDEILELRASSARALAFAFDCHGINLHRLRRQPGSYQDGFLRVCDAELQTWVYHEIGESLVDVFPGDLWQRIVSEQAGTLVEFFARTVRDILADTCRGGLLDHVIKERRSSSLGFYAALTRPLSRILYPEIVPAVQDFMQNPRWEKIEEVRTAGYKRGRELALNLMDVYEHCRQEDQERAGNQVMDRVIRPLGIVDSLEDENPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL34</accession>
    <name>D6SL34_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35395">
        <property type="protein sequence ID" value="EFI35395"/>
        <property type="gene ID" value="Dthio_PD2811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="33" mass="3767" checksum="9680E6F1DB6915E2" modified="2010-08-10" version="1">MGRDFGILGLKDSRSGINYILKIQSNGEFHERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL40</accession>
    <name>D6SL40_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAS modulated sigma54 specific transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868533.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2817"/>
    <dbReference type="EnsemblBacteria" id="EFI35401">
        <property type="protein sequence ID" value="EFI35401"/>
        <property type="gene ID" value="Dthio_PD2817"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="448" mass="49719" checksum="FCB127BCA7A87712" modified="2010-08-10" version="1">MSGKTTKDEPWEGFTKAILESISDGVFTVNREWMITSFNRAAEQITGISRDQALGRPCWEVLRSSMCQSQCALGYTLESGKPVIGKACYIIDSQGGRIPISVSTAMLRNSRGELVGGAETFRDLSEVERLRLELKGGLSTGNLVSHSPAMQKVLQIIPAVAASSSTVLILGETGTGKELAAKTIHSLGSKKDAPFVPVNCGALPDTLLESELFGYKAGAFTGAERDRPGRFAQAGNGTLFLDEIGEVSQALQIRLLRVLQEKAYDPLGSSRPEKTNARIITATNRDLEEMVRQKLFRQDLYYRINIVRIELPPLRHRKEDIPHLAQHFVDRFNRLQRKEVQGLTPEAVSLCMAYDWPGNIRELENIIERAFVLCSRGKIGIEHLPAELTLKDTEIPADFQTAKHILEARSIEKALEQTGNNKTRAARLLGMHKSTLHRKLKKLNIHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL80</accession>
    <name>D6SL80_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868573.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2861"/>
    <dbReference type="EnsemblBacteria" id="EFI35441">
        <property type="protein sequence ID" value="EFI35441"/>
        <property type="gene ID" value="Dthio_PD2861"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200118at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="205" mass="24337" checksum="4DD45BE5F1BB1049" modified="2010-08-10" version="1">MNWIEFKNKMFDLGCFSIHQVYAWQPGFDRNNLVRWTKKGYLVHLRRGWYAFPEYKDKPEFAEYIAGRIYNPSYISLHSALAFYGLIPESVVQITSVTSLKTASFTNEFGEYSYKSVKSDLMFGYFRRPIADGRTTPYATSEKALLDLLYLYPFYNTESELLELRLDGDILRTHWDRRTWLTMGKSFQCARLEKRMQLLEKVYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL90</accession>
    <name>D6SL90_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Cysteine desulfurase</fullName>
            <ecNumber evidence="6 10">2.8.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Nitrogenase metalloclusters biosynthesis protein NifS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD2871</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="6 10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868583.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2871"/>
    <dbReference type="EnsemblBacteria" id="EFI35451">
        <property type="protein sequence ID" value="EFI35451"/>
        <property type="gene ID" value="Dthio_PD2871"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017772">
        <property type="entry name" value="Cys_deSase_NifS_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03402">
        <property type="entry name" value="FeS_nifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="11">
        <location>
            <begin position="5"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="395" mass="43288" checksum="25400A596D9CFDEC" modified="2010-08-10" version="1">MKVTYLDNNATTRVAPEVMEEMLPFMDTLYGNPSSMHTFGGQVQKHLAQARERAAQALDCSPEEIIFTSGGTEGDNAAIFAAVNSQPDKRHLVTTRVEHPAVLNTCKYLEGRGYEVTYLPVDGYGRVNLDQLRESLRPDTALVSVMYANNETGNIYPVQAMAEMVKERGVLFHTDAVQVIGKLDLSMQKLPVDYLALSGHKIHAPKGVGAMFVRKKAPFRPFILGGHQENGRRAGTENTAGIVGLGRAMQLAAMDIAEENTRVAALRDRLEQGLTREVEQTRINGDRESRLPNTLNISFKYVEGEAILLMLDTLGVCASSGSACTSGNLEPSSVLRAMGVPFTHVHGSIRFSLSRYTTQEEVDLVLDHLPGIINKLRDMSPFGQGREPAASAPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLD8</accession>
    <name>D6SLD8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogenase</fullName>
            <ecNumber evidence="5">1.18.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the NifD/NifK/NifE/NifN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.6.1" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868631.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2922"/>
    <dbReference type="EnsemblBacteria" id="EFI35499">
        <property type="protein sequence ID" value="EFI35499"/>
        <property type="gene ID" value="Dthio_PD2922"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="397330at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018697">
        <property type="term" value="F:carbonyl sulfide nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000318">
        <property type="entry name" value="Nase_comp1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00699">
        <property type="entry name" value="NITROGENASE_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="4">
        <location>
            <begin position="18"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="454" mass="49545" checksum="97F971B008A0D042" modified="2010-08-10" version="1">MLDAATPYVSTTNACKLCTPLGACIAFKGLEGCMPILHGSQGCATYMRRYIISHFREPVDIASSALGEDQAIYGGGPNLMQGIINVMDKYNPDIIGIASTCLTETIGDDVPMILSGFKKEFAHLKIPELIHVSTPSYSGTHMEGFHRAIRQTAIQMAEPDPLPHSKITVLPGFVSPWDVRHLKGVMRDFDIPGIILPDISETLEGTIQEDIEMVPSGGTSMQDLKSLGGSPACIELGNCIKNDLSTAGWLEKNLNVPAHRLGLPIGLRGMDAFMQTLSRISGKDMPREQMLERGRLVDAYVDAHKYLFGKKCLIYGEEDLVTGLVSFLAETGVQPVLAASGGRSGLMQKSIEQACDGMLPQTPSVLSGVDFYQIVEEAEKLEPDFILGNSKAYRIAAGKWDIPLIRVGFPVHDRMGAGRIRHAGYEGAYDLLMRIVNTLLEKRQEDADLGWGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLD9</accession>
    <name>D6SLD9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FeMo cofactor biosynthesis protein NifB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nitrogenase cofactor maturase NifB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Radical SAM assemblase NifB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD2923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; Fe-Mo cofactor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. NifB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868632.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2923"/>
    <dbReference type="EnsemblBacteria" id="EFI35500">
        <property type="protein sequence ID" value="EFI35500"/>
        <property type="gene ID" value="Dthio_PD2923"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00782"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005980">
        <property type="entry name" value="Nase_CF_NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43787:SF3">
        <property type="entry name" value="PTHR43787:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01290">
        <property type="entry name" value="nifB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="17"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="430" mass="47307" checksum="AAAC23D984389402" modified="2010-08-10" version="1">MSKLDLSRHPCFNKKAKGGCGRIHLPVAPKCNIQCNFCNRKYDCVNESRPGVTSAVLTPVQAVEYLKEVQRLEGSLTVAGIAGPGDPMANAPQTLETIARVRSEFPDLLLCLSSNGLNLPDHVTELKKLGVTHATVTVNAIDPETGKDIYAWVRDSKVAYQGREAASLLWSRQKEAILKLRENGILVKMNSIVLPGINDHHIQDIAEKAGEMDVSLLNCIPVHPSPGARFENIDEPDKAFIDSLRKKASQHVPQMTHCRRCRADAVGLLDRDRSLELAPVMRDVAARPVIPDDSEKRPHVAVATREGMLVNQHLGHAEKFQIWTRSNGDYKLVESRQAPEAGGGLQRWHEMARVLQDCRAVIISAVGDTPRTVLEKSGMVVLEMEGLIEEGLDAAYKGTDVSGLRPVKTKSCSGGDSWRLRIRVGGDFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLQ9</accession>
    <name>D6SLQ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3049"/>
    <dbReference type="EnsemblBacteria" id="EFI35620">
        <property type="protein sequence ID" value="EFI35620"/>
        <property type="gene ID" value="Dthio_PD3049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="161" mass="17859" checksum="7B2CC6C1C8F2D8DC" modified="2010-08-10" version="1">MHHPFVAVDDDQRQEKSVNIHFSRPVHVVHDSLGNGRVAGKFHGQAGPELVVASAMLHTVKFTHIVQQSRSLNRPGINLHSLLQGQGADFSGNKGYQDAVIYDMLGKVVKFQVMKAFLPGGHFPPGVYWVRNWLESINHCLYCGPWGFWLSACLQSALICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLY3</accession>
    <name>D6SLY3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868823.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3123"/>
    <dbReference type="EnsemblBacteria" id="EFI35694">
        <property type="protein sequence ID" value="EFI35694"/>
        <property type="gene ID" value="Dthio_PD3123"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1964193at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="115" mass="12778" checksum="647490C648094146" modified="2010-08-10" version="1">MRKTALFVFNGDPMCFIHVLLNALNMKEKGHEAGIVVEGAATKLIPELVRDEHPLSDLWSKVKDKNLVYGVCRACSHKMGTLEDARDQSLALLDDMSGHPGMAGYQDRGYEVITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM28</accession>
    <name>D6SM28_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3168"/>
    <dbReference type="EnsemblBacteria" id="EFI35739">
        <property type="protein sequence ID" value="EFI35739"/>
        <property type="gene ID" value="Dthio_PD3168"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="227"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="449" mass="50737" checksum="284A122B2F19377F" modified="2010-08-10" version="1">MDENKKKLTIYEKIVKFFLTDGKGCIIAVSQDSLLIKAVKAMYKALGIDANSFFHKQNLEKAGADAKSLLTRFNQVVFLVESSTDGASNVLNIKNFKNILGHKCKVIVMTSETDRSNIIQMYEMGADNVIVKPVSVNSLIQKIALTLNPNNELAQKVDEAKALLMENHLDQAENVVQEIINQKPDSAIAYILKGDIAKKRKNFEAAEKFYIQASGTSKMYLEPLKKLARLYSEMNNLEKKLEYLKKLDKLSPLNHERKIDLGDTYLRMDNEEEAKANFDQAIRQVQKQARDLISSTIMQIARKVRDERPDLSSQYVAKAIEHKGSALSREDIWMFNEIGISLRQQGKWEEAIGYYSQGLKIAPMDGGLYYNVGMAYAQGKQYYKALENFQKAVEVSPELVDQYSSVAFNMAKVYQALNRPGDAVKYLKKALEVDPENQSAQNLLAKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM43</accession>
    <name>D6SM43_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868883.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3184"/>
    <dbReference type="EnsemblBacteria" id="EFI35754">
        <property type="protein sequence ID" value="EFI35754"/>
        <property type="gene ID" value="Dthio_PD3184"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533403at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="375" mass="43430" checksum="AB447AD6EB714D06" modified="2010-08-10" version="1">MSEYQYYEFLTVERKLTSKEMSALRNISSRAHITPVSLTNVYNFGDFKGNPTDLVRKFFDAHVYMANWGTAVFMINLPLEAISRETVETMQAEDFLDFKAFQNHWVITWSLDEEPEDLDRFVMDDGTSWMQRLLPIRDELLRGDLRSLYIGWLAAVTKEMVDDDELEPLSLEGLKSLTPAQQALAEFLEVDPDLLAAAGMGSTDAEDPERKQEMMEKWLNTMSHERLVSVSRLLLTGQSQQAERELKNEYYAWMRSLSDGSSRKDLRTVEELRENADSAQKIRLEKERLKKKKEEENAAKKDKPISRSWPRIATRNGKQFKVLWPVVPGWLTRKRARPLLTYLRPVPTTGIQRLFSRSSINSWKITCVAKHLSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM46</accession>
    <name>D6SM46_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868886.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3187"/>
    <dbReference type="EnsemblBacteria" id="EFI35757">
        <property type="protein sequence ID" value="EFI35757"/>
        <property type="gene ID" value="Dthio_PD3187"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1906817at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="102" mass="11724" checksum="4F9BB196F9FC573A" modified="2010-08-10" version="1">MQPPPSPDSMDKEKFRRLVVNRWKVSLSLTAIMMLAYFGFILVLAYAPHLLSVKIGEHMTLGIPVGIFVIVLAFILTGIYVFWSNSYYDKSVQEILQSMRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM58</accession>
    <name>D6SM58_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3201"/>
    <dbReference type="EnsemblBacteria" id="EFI35769">
        <property type="protein sequence ID" value="EFI35769"/>
        <property type="gene ID" value="Dthio_PD3201"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="83" mass="9419" checksum="46CB5CCB8B5699E2" modified="2010-08-10" version="1">MMQLQKVSRDSIFLPDKSGSLKRVPHQEYQSEDMLQDIVDRHPELIVGEQINPDAPPGWLVIRREAGIAGSDTEGSRWSVDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM87</accession>
    <name>D6SM87_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NADH:ubiquinone oxidoreductase, subunit G, iron-sulfur binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD3233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868927.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3233"/>
    <dbReference type="EnsemblBacteria" id="EFI35798">
        <property type="protein sequence ID" value="EFI35798"/>
        <property type="gene ID" value="Dthio_PD3233"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="8">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="11">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="10">
        <location>
            <begin position="220"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="682" mass="74811" checksum="0E77687E38DB4001" modified="2010-08-10" version="1">MDKQVKLRIDGQEVQAPAGMNLIDAAELAGIHIPNLCYLKGMKGIGACRMCLVEVEGLKAPVIACNTKVKQDMAVHTRTERVQEIRRFVVDLILSMHPLDCVTCTKSGVCNLQDYAYEFGLRESSFSRKKFTYPVDEGNPFVKRDPAYCILCGRCVRVCKEQGTNVLDFMGRGIESKVITANDMPLHESGCTFCGSCIDVCPVSALREADREQKGREWEFSRHESVCMLCGCGCDITVSTKGDLIQKINAGSKAPSTEQHFICTYGRFGYEHVDGGKRILSPMVRKGGQLQEVSMKDALEDLAGRLKKAGKNTGFISTASILNEDAMTLQRFSGEVVKTSSIDSTASLYARPEQLEKSQKAKIDKADLIILVGVNPSQWTRVLPALDVAVRRRLSRKGRLITINSQETALDKLAEINLNGDEIQAIQGMIKSVPDHGIKVDQKLLKHVQEASTDKNMQQAAEMFAGSSNPLIISDPAFFDVASNLAWIKGQAMAMPLESNARGVVLMGVKSKDNTFQDMAAVEHGLVQRGRSTVKLLYAVGDVPLSKKPDGVDFLVVQSSSFTGLAREADMVLPAATYLESSGSMVDYLGQLKTVEQAIEPRGESRTHRDIFIQLAKNMGVTLKKPTFSEVKKAAGSEVSLSVADMTRKEAFQETPESYLQALNAPVLETSRLLWLKESGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM95</accession>
    <name>D6SM95_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868935.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3241"/>
    <dbReference type="EnsemblBacteria" id="EFI35806">
        <property type="protein sequence ID" value="EFI35806"/>
        <property type="gene ID" value="Dthio_PD3241"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="952726at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040506">
        <property type="entry name" value="RACo_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17650">
        <property type="entry name" value="RACo_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="631" mass="68204" checksum="B060EDAE33B792D3" modified="2010-08-10" version="1">MFNVTFLPAGKQVQVEQGENLLRAAMLAGVQFSASCGGSGSCGKCKVLVEKGEFESDVSARISAADQEKGYALACITRINSDIEVHLPEDARAIDRQAIERAMLTSVEPSELLGHIEINPSVQRIYLELPPPSLEDNVSDIDRLTRALEKQLGSKKIHLSLPLIKQASSTLRSSGWKATFTVFATDEGFEVTQVFPGHRTEPVYGLAVDIGTTTICAELVNLENGRVQAHRSDYNSQYSCGEDVISRIVYASRNRENLAHIQGLVHSTLNGLIQEMLKETGVQSQDIADVVMSGNTTMTHLFMGVEPGIREEPYVPVTSAPPVLQAGELSLEWSDSARIYLTPSRASYMGGDITAGLIGSNLFRSEKLTLYIDVGTNGEIVLGGSEWLIGCSCSAGPAFEGGAIKHGMRAATGAVEQVRIDPGTFEPMILTVGQSSPRGICGSGLIDAMAELLMAGVITSKGRFNTELDTPRIRGQEALEYVLVWAEDAQNGQDIVITEGDLDNLLRAKAAVFAGITTLLNAVGITLQDVDELLIAGGFGRYLELDKAVTIGLLPEISPDRVKYIGNGSLLGSRVMLLSRRMRQEALQVCKKMTYLELSQDPSFMDQYVSALFMPHTDMSMFPSVQASLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMA9</accession>
    <name>D6SMA9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868949.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35820">
        <property type="protein sequence ID" value="EFI35820"/>
        <property type="gene ID" value="Dthio_PD3255"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503371S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2007362at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="111" mass="12928" checksum="2DEAAB6C1DA5FEDD" modified="2010-08-10" version="1">MKINIDNNLVELAPENTDEAQDLEKLWKLIVDCVRENKKLNPVGEYHPQKNSQARFHIEDIPAPEPRKTQWSTSKASEDNTFYCSICNKYIHIVKDQEIPLCCGREMEPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMD4</accession>
    <name>D6SMD4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD3283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868974.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3283"/>
    <dbReference type="EnsemblBacteria" id="EFI35845">
        <property type="protein sequence ID" value="EFI35845"/>
        <property type="gene ID" value="Dthio_PD3283"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="72"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="298" mass="31793" checksum="AACDA24486818F6D" modified="2010-08-10" version="1">MAVISSQKKDLLVHGVFLIVGASGIIILTLIFLFLILEGLPIFDVISVRDFILGKEWYPTDINPDYGILPLIAGSASVVALASIMAIPLGVFSAIYLAEIAHPKTRAVIKPIVELIEGLPTVVIGFFGMVVVAPFLQEMFDLGTGLNVLNASIMLAFMAVPTITSISEDAIYSVPRHMKEGSMALGATQWETIARVIVPASLAGISTAVVLGIARAIGETMVVLMVAGGAAMIPESIFDPVRPMPANIAAEMGNVPFRSDHYHALFAIGLVLFVFTFLFNLLASYLSERHKQVGAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMG9</accession>
    <name>D6SMG9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869009.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3319"/>
    <dbReference type="EnsemblBacteria" id="EFI35880">
        <property type="protein sequence ID" value="EFI35880"/>
        <property type="gene ID" value="Dthio_PD3319"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1691156at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="138" mass="15860" checksum="FF0539F16FA5A66B" modified="2010-08-10" version="1">MKSYRQELWMNIPARMDFENITPRVQDAVNKSGVSEGLVLVNAMHITASVFINDDESGLHHDYKIWLEKLAPHEPVSSYRHNVGEDNADAHMKRQVMGREVVVAITEGRLDLGPWEQVFYGEFDGRRKKRVLIKVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SML8</accession>
    <name>D6SML8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869057.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3371"/>
    <dbReference type="EnsemblBacteria" id="EFI35929">
        <property type="protein sequence ID" value="EFI35929"/>
        <property type="gene ID" value="Dthio_PD3371"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="15913" checksum="1638F558084B4506" modified="2010-08-10" version="1">MSDARPDPDKGCFSLAIVDIDNSKQINDTYGHYCGDQVLVSFAQVLQDNVRETDAVGRWGGEEFILLLPETGLEAAATACEKIRGIMARSSVCYQDCQIMVTATFGVSQYQVEGGIEETLRYADEAMYRGKQAGRDRVVMAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SML9</accession>
    <name>D6SML9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869058.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3372"/>
    <dbReference type="EnsemblBacteria" id="EFI35930">
        <property type="protein sequence ID" value="EFI35930"/>
        <property type="gene ID" value="Dthio_PD3372"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10666" checksum="85158F380B23A6F6" modified="2010-08-10" version="1">MIKSFKHKGLEVFYYYGSTRGISPEHADKISRILDRLNAANDIIDMNFPGSNLHKLSGKLKGQYSVRVSGNWRIFFKFIEGDAYVVDYDDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMP6</accession>
    <name>D6SMP6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar biosynthesis protein FlhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flhA</name>
        <name evidence="8" type="ORF">Dthio_PD3399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869085.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3399"/>
    <dbReference type="EnsemblBacteria" id="EFI35957">
        <property type="protein sequence ID" value="EFI35957"/>
        <property type="gene ID" value="Dthio_PD3399"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="436367at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006301">
        <property type="entry name" value="FlhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01398">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="701" mass="76728" checksum="DC5E4CB4A829DD22" modified="2010-08-10" version="1">MAVKSSVLGNINYARFTKQGDILLAGGVVVILFVMLVPMPPVLLDLLLTFNLSFAFVILVTSMFMRSPLEFSIFPSLLLIATLFRLALNVATTRLILLHGDQGTHAAGRVIESFGTFVVGGNYFIGIVIFLILFALTKMVIANGTTRIAEVAARFTLDSMPGKQMSIEADLNSGLIDEQEAKRQREALRKESDFYGAMDGSGKFVSGDVNAGILITVINIVGGLIIGIVQHGMSWGEAAQTYTLLTIGDGLVAIIPSIIISTSAGIIVSRAAAEAQMGQEFLGQLTNHPRALRLVSGVLLLFGLVPGMPTFVFLLMSGALFTLSILSARNKTEIEEQAAEKKEDSQAALETPAEVHSLLPLDTLELEVGYGLIPLVDEDQDGNLLARIRSIRRQFALDMGVVIPSLHLRDNLQLKPGEYAVLIKGNQVARSEIMIDHYLAMDPGDAKHRIKGIETLEPAFNLPALWIPENKKEEAVMAGYTVVDPSTVIATHITEVFKHNLHEFLGRQETQNLLDNLAQRAPKAVEDLVPNILTLGTVQKVLQNLVKEKVSIRDLLTIVETLSDYGQQTRDPEQLTEYVRQKMGRTIVRPYLSEDGTLPIITLDESIEKSFQEGLRQTDHGTYLAMEPNLAQKIINSINKTLEKTTVADGQPVLLTSPLIRPHLAQLLLRFVPNLPVIAQTEIPTNIRLESVNTVSMKNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMQ7</accession>
    <name>D6SMQ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated CheW protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869096.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3410"/>
    <dbReference type="EnsemblBacteria" id="EFI35968">
        <property type="protein sequence ID" value="EFI35968"/>
        <property type="gene ID" value="Dthio_PD3410"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024181">
        <property type="entry name" value="Chemotax_regulator_CheV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002867">
        <property type="entry name" value="CheV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="181"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="320" mass="35471" checksum="8A08596A4095E10C" modified="2010-08-10" version="1">MTNSDILLEAGTNELEIVEFFLDEDLDGESYQGFYGVNVAKVLRIINKPEVTEMPSTPHSCVLGAFNQRSRIIPLVDLGLWLDKQAVESGSSKVIITEFNRVVTGFLASGVTRIHRLSWDEVEPPDAYVDSFSAGSITGVVKIEDRIVFILDLEKILAELSPGMGMNLDQELQSDSESGYTALVADDSTLIRNMISDLLEKAGFRVIKFKNGQEAWNELEKIKNTCSSEDKSLDSLVHIVVSDIEMPAMDGLTLTRKIKNDSVLGNLPVILFSSLISDRLRHKGVSVGADDQVSKPEVSLLTQKAMKLIRDREQSFKSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN18</accession>
    <name>D6SN18_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869207.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3526"/>
    <dbReference type="EnsemblBacteria" id="EFI36079">
        <property type="protein sequence ID" value="EFI36079"/>
        <property type="gene ID" value="Dthio_PD3526"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9PB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="668062at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="421" mass="47742" checksum="725B12FDB1144FF2" modified="2010-08-10" version="1">MLRPGSDRLSYSHLLAPPPDYYTDFALGTTYSLDLEAMLGIPMALFMSEELGSSATQNPVAVLEGLRRSTDNLAIFCEPGQIKIPHKNNTVYSLVESSVFQVHLPRGRSFHPKVWVIRYAGPQKDPIYRIIVLSRNLTFDRSWDMAVCLDGKKGDEPTEKNSPLQDFIGFLIQHINSRKKRRRIKNIQEEIGQVYFDPQIQQVADFQFCPLGIDGHDKKSSSLFQSYKDLVIISPFLSKTPVKEFDSLALSNSSRTLITRRAELPKLLPEHFESFQVYVMKELVAEGEEGLSEDELQAEVPQNQDIHAKFYARSKGSNHALYFGSANCTQRAFDANVEFLLKLDYRKWGFKLADILEDIFGKDDKDNPFEKIESIPQGDFSDDDPADDLQRAIKELCRGKMRAHVISGEHQTETAGRGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN54</accession>
    <name>D6SN54_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SapC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0474</name>
        <name evidence="3" type="ORF">Dthio_PD1528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869510.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0474"/>
    <dbReference type="EnsemblBacteria" id="EFI33151">
        <property type="protein sequence ID" value="EFI33151"/>
        <property type="gene ID" value="Dthio_PD0474"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34180">
        <property type="protein sequence ID" value="EFI34180"/>
        <property type="gene ID" value="Dthio_PD1528"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1512520at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010836">
        <property type="entry name" value="SapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07277">
        <property type="entry name" value="SapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="236" mass="26678" checksum="FA177A9BEC2DBB8C" modified="2010-08-10" version="1">MQPLSKTTHAGKSFHPAKNYQHAKTRTTVPMVISELPRAVPAFPIAFTYSRNKYVLSAVMGLKPEQNLFVTQEGKWQTSYIPAYLRGHPFYLAESQEGKQVVCVDENSDLITDGPDGEQMFGEEGKPTQKMQQIIDFLEKIARERAITDRACAALAEFGVIEPWEGYGGLYKVSEAKLKDLSGEAFVKLRDTGGLKVMYGQLYSLTQMARLKKLAEQDKEPDWESMEELDFEKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN79</accession>
    <name>D6SN79_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1556"/>
    <dbReference type="EnsemblBacteria" id="EFI34205">
        <property type="protein sequence ID" value="EFI34205"/>
        <property type="gene ID" value="Dthio_PD1556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="87" mass="10110" checksum="845655B0EF4C0016" modified="2010-08-10" version="1">MSNQDWELTADSLNDFRASVDYQNGNLSDQDDFNKEVDLHFMNGIFWVTRPSKCPFYGLPGSFFHPEKNNQGKKKMTSWLKSIMISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNA1</accession>
    <name>D6SNA1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869555.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1578"/>
    <dbReference type="EnsemblBacteria" id="EFI34227">
        <property type="protein sequence ID" value="EFI34227"/>
        <property type="gene ID" value="Dthio_PD1578"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241492at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="461"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="759" mass="85607" checksum="7F5C4AF1B0B7A123" modified="2010-08-10" version="1">MLRSDVNDLKNQSSEEETPEREILALRRRKSLYPQTLEQMKNIWPFAKPMPAGPEDTRKASVAVVVNFSLKTSGYEFVSRYTAELVSRLVRNGAKPVLLDLANEQRNDNTRIAVESLWPQGSIVYEQVEEPDVPPSYGPLARTASMAYRLYEWLKKRDFDAVHGPDNLGVLSLCLRARQQGIAFAKTRFVVHPADALLQKCLDEYQNLNNVLSLPRIYMESSSLEMADTVPVTGRYGLRRLLEAGINLRPGQVEHCPIPHDSKAAREQFQGVQSGEFRRVLCLPGVSRRGTALFCKALNRGFPGTSASFAVEFAVPDDYQKDLASYAKALLSGRSEQTVVRSVPDRRSLVRLLSENPDTLCVFPVIDEWNIYQLMDLAAAGLPLVAADQHKARDLLDEETAKHSTCAPLPDAIARHIREVLKGRACYARVQSEGDLPASWISPGEPKTSTEEQGEPPLVTVCLMHFERPHLLEQALASVENQVYTNLEVVLVDDGSLKKESIQKLEELKARFQEKGWNIIRQQNRFLGAARNTAAMEARGRYLYFLDDDNILKPHALETMIRVAEHMPADIVTALSDAFEGDTPPASDATASRRIIQIGDDLSYGIFRNSFGDSNALVRRSVFLELGGNTEDYAVGKDDQEFFARAVLSGCRLTIVPEALYWARQMSARLRTLHFNPRAGHVRVCRAYLPHVPPKLRPLLLLSTGLMEESFEGRDITLRGFILHKIKRFARTRFGAWLRFGILGPFLRWRRELRMKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNG2</accession>
    <name>D6SNG2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869616.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1639"/>
    <dbReference type="EnsemblBacteria" id="EFI34288">
        <property type="protein sequence ID" value="EFI34288"/>
        <property type="gene ID" value="Dthio_PD1639"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="479"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="568" mass="61993" checksum="6FBF72F124076E84" modified="2010-08-10" version="1">MSQQVVIIGAVALGPKAACRLKRLEPDSRVIMIDENEIISYGGCGIPYYVSGDISDAQELQSTTFHMVRDVSFFREAKDVEVRTRTRALSIDRMARQVHVHDLEKDEKYHLDYDKLVLSTGSSPRKLPLPGVDLPGVYTVSGLEEAIRLKGQISQSGVEKAVVVGAGLIGLEMAEALADLWGIETSVVEIAPQVLPGFISPDIARMVRNVLEENDISVYTGEQVKEIFGEDRVKGVRTDQRELEADMVILAAGVIPNSDLAREAGLEVSPQGAVVVDRHMRTSDEHIFAGGDCVQLQNLVTGKPGYYPMGSMANRQGRVIGTNLAGGNDEFPGAVGSFVVKLFDHAVSGTGLSIETASRQGFDAVSAFVTQFDKSHFYPEKDLLYLELVVERGTGRILGLQGLSTGGDSLKGRIDCVAALLPGKPTTKDLSNLEVSYSPPFGSAMDALNSLGNVAENILQGFNKGLRPAEFAELWEKRQDKDVVFLDCRDEDNARPFMDKYPEKWKNVKAETLDLNLDKVPQAETVVLLCNNGARSYEARLKLARHGITNTLNVHGGMSMIKKWGVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNG4</accession>
    <name>D6SNG4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Lon protease</fullName>
            <ecNumber evidence="6 7">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lon</name>
        <name evidence="14" type="ORF">Dthio_PD1641</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7 10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="6 7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869618.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1641"/>
    <dbReference type="MEROPS" id="S16.001"/>
    <dbReference type="EnsemblBacteria" id="EFI34290">
        <property type="protein sequence ID" value="EFI34290"/>
        <property type="gene ID" value="Dthio_PD1641"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="13">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="12">
        <location>
            <begin position="604"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <begin position="365"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="815" mass="91677" checksum="68181047D1D0CC75" modified="2010-08-10" version="1">MTKKTNAGKATPKGEKLPLMTLREVVMFPKAIIPLLVGRDSSIKAIEHALNNYNKKIFLVTQNDPKTEKPGPEDIYACGCVSRILQMFRLPDGTVKVLFEGLHRAAVNPEKVDFEEEVPEVETHFLPEEENDHSETEALVRATKESLEEYSKANTKIAKESVQSIQNMDDPGAIADAIMPHLKVEFNEKQEVLEEFDPFKRLQMAYAHLQGEIEVFSLEKKIKSRVKNQMEKNQREYYLSEQLKAIHKEMGRDHDPKAELDVLQEKVDQKNMPQQAKDKASEEIKKLRSMPPNAGEYSVLMNYVDWVLALPWNELRETDTDITKAEKILDEDHYGLEKPKQRILEYLAVQSLVEKMRGPILCLVGPPGVGKTSLAKSVARATQREFIRLSLGGVRDEAEIRGHRRTYVGAMPGKILQSLKRVDTNNPVFCLDEVDKMSMDFRGDPSAALLEVLDPEQNSAFSDHYLDLDYDLSNIFFITTANYLQAIPAPLQDRMEIIKLPGYLETEKNRIARHFIWPKQLNYHGLEDSKVSISEGAINEIIRQYTREAGVRNLEREIASICRKVAKKKVEEKDRKDKKVRVTAKSVPSYLGVSKIRHGEREDKPLVGVTNGVAWTEVGGEILLVEVALMPGTGKVEITGKLGDVMKESAKAALSYVRSRSDVFGLKSDFYKEIDVHVHVPEGATPKDGPSAGITLTTSLVSSLLNLPVRNDLAMTGEITLRGRVLPIGGLREKLLAARRGDINKVIIPEANQKDLQEVPDNVLKGLEVMPVQHMDDVLAEALMGTTREDLFCGDANITPISSKLMKEEYQEQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNG5</accession>
    <name>D6SNG5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenide, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">selD</name>
        <name evidence="8" type="ORF">Dthio_PD1642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1642"/>
    <dbReference type="EnsemblBacteria" id="EFI34291">
        <property type="protein sequence ID" value="EFI34291"/>
        <property type="gene ID" value="Dthio_PD1642"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="139"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="319" mass="34329" checksum="6B3D2A4A20164194" modified="2010-08-10" version="1">MQGLEFPKDSNLIVGLDRADDAGVYKVSDDLALIQTVDFFTPIVDDPYWFGQIAAANALSDVYAMGGEPKTAMNLVGFPLGKMDLEVLRQILMGGLDKMREAGTVLVGGHSVEDAELKYGLSVTGFVHPDKILTKKNLQAGDRLILTKPLGTGIVNTAIKGGAASQEHIQKVTRLMAELNKAAAEVMRQYDVHACTDITGFGLLGHMAEMLCGSKVSLKIDFGSLPVLPEALEFASMGMVPAGAHKNRHFRENIVEYSDGITPAKRDILFDPQTSGGLLICCPPDQARDMLRNLHSRGLSEAAIMGEVDSSSAEKILVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNH6</accession>
    <name>D6SNH6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="3">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD1653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LpxB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869630.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1653"/>
    <dbReference type="EnsemblBacteria" id="EFI34302">
        <property type="protein sequence ID" value="EFI34302"/>
        <property type="gene ID" value="Dthio_PD1653"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1258510at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="372" mass="42157" checksum="8C294CEC4A64F732" modified="2010-08-10" version="1">MRKSIWINVCESSADAYGALLMQELQQMCPGMRIMGMGGRAMRRQGLETVYRAEDLSLVGLTEVVTALPRIAGYLSEIKKRLRRERPGVLVLMDAPDFNFRLAREACRLGIPVIYYIAPQVWAWRRSRIKFLKEFVHRVACIFPFEQDFFLSRGIVARYVGHPLLDLIHLPELNLIAPQENRIALLPGSRKKEIASLLPVFTDVAYKLSLKRPDLSIGIVQAPGVDRDFIKRHTKDLPCLEFVSPEERHSYLKSCSMALAVSGTITLECAILDVPAIVAYKVSWPSYLAGRMLIDVPYISMPNLILDRGVFPEFIQSRASSQELLQAAGSWLDHPRRLADVRRELAQVKDLLGKRKATRNTAEMIMQAMYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNJ6</accession>
    <name>D6SNJ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869650.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34322">
        <property type="protein sequence ID" value="EFI34322"/>
        <property type="gene ID" value="Dthio_PD1673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="15408" checksum="925018B15C682DDD" modified="2010-08-10" version="1">MAEIEGGVSLGSMGHDVQKKDQVKKPQGPETTDKNNELNAPKTGRPEKPAPEKSQNPMEMKNKEPAKMSLEEEAQKTVNNMPLADGAQQSPGIGMPGATQPQPMGGASPMQGMPAGGSAFGAPAGMNSAGAGPGAGPMPGMPGQGSMLNTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNL0</accession>
    <name>D6SNL0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869664.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34336">
        <property type="protein sequence ID" value="EFI34336"/>
        <property type="gene ID" value="Dthio_PD1687"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10541" checksum="E938B4F25247F84C" modified="2010-08-10" version="1">MQLQFTIHIWKKGDWFLAKCPELDFISQGTTRDEAEKNLMEVMQIQFEEMSLMGTLDDYLKECGYDFDKDTGTATPQAKMIGSESFEMQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNL8</accession>
    <name>D6SNL8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869672.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1695"/>
    <dbReference type="EnsemblBacteria" id="EFI34344">
        <property type="protein sequence ID" value="EFI34344"/>
        <property type="gene ID" value="Dthio_PD1695"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1482252at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="284" mass="30953" checksum="55A71F9A17DF752B" modified="2010-08-10" version="1">MSWLIVGTVPEEDFPLVHGPVEVHSQSLRVLEREVKIARGTPALAAFTAMAAREMGLSMPHVMLVGDTGDGQGSRALYAHLVEMVDKLEIEGFTFHYLLPDIYWHNQVLWAIQEKLPSAMLVADAGFMYVAKMSGFAADYDLFTPDIGEMCFLADETAPHPFYTRGFLLEDESKVEEYISRAYSEQNAARHLLVKGAKDYIVRDDVILDTVSEPSVAAMEAIGGTGDSLTGIVTARLMAGEDIPAACHKSALTNRHLGVLGRPTPAYSIGHLLPYLAGAMQEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNM3</accession>
    <name>D6SNM3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869677.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1700"/>
    <dbReference type="EnsemblBacteria" id="EFI34349">
        <property type="protein sequence ID" value="EFI34349"/>
        <property type="gene ID" value="Dthio_PD1700"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="12738" checksum="D2FACCE940130E97" modified="2010-08-10" version="1">MTKANIRIQDAASYRLDEIYHHTLNRWGMQQADRYITGLFDAFNGIADHRTLSRPVPAEFGIEGYFFRYERHFVYWRWLSNGDIGIVTILHERMHQIDRFREDFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNQ9</accession>
    <name>D6SNQ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1738</name>
        <name evidence="4" type="ORF">Dthio_PD2590</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869713.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1738"/>
    <dbReference type="EnsemblBacteria" id="EFI34385">
        <property type="protein sequence ID" value="EFI34385"/>
        <property type="gene ID" value="Dthio_PD1738"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35188">
        <property type="protein sequence ID" value="EFI35188"/>
        <property type="gene ID" value="Dthio_PD2590"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1272226at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="193"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="530" mass="60295" checksum="C3406E21EB2DEE8A" modified="2010-08-10" version="1">MKKKVQSIDLDQEQIDALLQRASKNELEETDLDIIKALVQAIQLLHQAVDDKAASIKRLLRTIFGASSETKKKLFQEDDQQNKDQKGSQDPLQKPPDEKPPKGHGRNGKDDYTGAANCIYPHQTLKPGDICPLCGQGKVYPIKPKFRIRITATAPLTAKIHELKSLRCNCCLEVFTADPPEDIGEKKYDEPARSMIAILKYGSGFPFHRLEKLQESLGIPLPAATQWDLVEQTGTQLLPVYDELIRQAAQGEVVHNDDTNMKIQQLIKENKEAGPKRKGMFTTGIVSVLQGRHIALFATGRQHAGENLEEILKKRDHNLPPPIHMCDALARNIPKGLQIILANCLTHGRRNFVDILDNFPDECRYVIEQLAIVYKNDDMAKKQEMSAQERLVWHQQESAPVMSELKSWAWAQLEEKKVEPNSGLGKALAYMQKHWDPLTLFLREPGAPLDNNICERALKKAIQHRKNSLFYRTLRGARIGDLFMSFIHTCQLNKVNSFDYLTQLQKNIEEALAAPQKWMPWNYRENLPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNS6</accession>
    <name>D6SNS6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869725.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1758"/>
    <dbReference type="EnsemblBacteria" id="EFI34402">
        <property type="protein sequence ID" value="EFI34402"/>
        <property type="gene ID" value="Dthio_PD1758"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942490at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="81" mass="9120" checksum="60327C55D66B2539" modified="2010-08-10" version="1">MIELPYSLVIEATEEPDYFGFYSPDLEGFSGIGHSVEDCLFKAKWGMQEHVELLKQEGLPVPPNNSDPRIIIQNEKKLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNT5</accession>
    <name>D6SNT5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1769"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0711">Selenium</keyword>
    <keyword evidence="1" id="KW-0712">Selenocysteine</keyword>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="110" mass="12528" checksum="534C827BF6AD3C86" modified="2010-08-10" version="1">MVLLSCIPLSDIYPDTWGQRPVLALTPPDTFEDMVCLAITSSPLHHAAFPLNNECFLEDILPKPSUVRLDKVYTLNAGLFVGRFGSLHADVFERVKRHFCEHFVCHLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNU7</accession>
    <name>D6SNU7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1781"/>
    <dbReference type="EnsemblBacteria" id="EFI34423">
        <property type="protein sequence ID" value="EFI34423"/>
        <property type="gene ID" value="Dthio_PD1781"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033AFM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="11717" checksum="B1B2D2C90898F371" modified="2010-08-10" version="1">MTMSQITVKRIKAHWVDRARNYGILVDGKEVAEIGNDSEVAIDVDPGAHKVQLKIDWCRSPVIDIEVSQGKTVYLECGPRAHPALVLLYITVWKDKYIWVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNX7</accession>
    <name>D6SNX7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD1812</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a membrane-associated complex with FtsE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869775.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1812"/>
    <dbReference type="EnsemblBacteria" id="EFI34453">
        <property type="protein sequence ID" value="EFI34453"/>
        <property type="gene ID" value="Dthio_PD1812"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1653234at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="11">
        <location>
            <begin position="58"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="292" mass="32691" checksum="9C051B4B7835A856" modified="2010-08-10" version="1">MRVLARLFMQGLANLGRNRWAQFFTLSTVAFTSFMAGIFLLALYNVHLTAQSTQEDIQFQVYWDSGHPQQEVQEQWEEIKSWDIGGINTFTPDEALKSLAESISGDMDVSYLSRENPLPATALVKFSLEGENSRDRAQKMRSRLMDLPGVERVSYNPVQLDLARTWVRVSSGIFWPLIGLMLLITGLVVANTLKLNQMQRREEVDILALVGASGRYIQFPLLVSGALQGFLGGVISLGLLKLLHLTLEDVLYFPPLWIRIEFLPLPSALAIPGVLTLVGILSSFLAVRGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNY2</accession>
    <name>D6SNY2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">Dthio_PD1817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869780.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1817"/>
    <dbReference type="EnsemblBacteria" id="EFI34458">
        <property type="protein sequence ID" value="EFI34458"/>
        <property type="gene ID" value="Dthio_PD1817"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="364"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="552" mass="61629" checksum="9DA07F09115CAFBC" modified="2010-08-10" version="1">MSEKDDYVTLTPLGGLGEIGQNCMVLETPGTMVLIDCGLMFPDDFLLGVDVVIPRFDYVLKNREKLKAIILTHGHEDHIGALPWLLPYVDAPVYGSRFTLKLVENKLREFNLLEYTRLEVMDHKTPLQVDDLTFNFFQVCHSIIEGFGIGIETPVGRIVHTGDFKLDPEPLDGHFTDLEAFAGFSREGVLLMLSDSTNVEREGYALTEREIKDSLGKVFAEARGRILVTLFSSHIQRMQEIFDLAMEHGRKVAVSGKSLASNIEMAMEEGFMRVGSGTYCTLDEISGVEDSRTVLLLTGSQGEPLSALTRLALGEHRQLKVKPGDTVLMSSRIIPGNTKAIARVINNLYRLGAEVFYEKVRAIHASGHAHKEELKTMLKTVNPRFFIPVHGEYRHLFKHAALARECGVAPERSLIVENGQPVTFFQDSIRLEDRIPSDSTLVDGKGVGDVGHTVLKERHILGGEGLVIVVMVISESTGELVMGPRILSRGFIFEQQYDHILEDAKCLLLDVFENVPPGESRKLEEKIRSTLRKFFRKILGRDPIVVPLAIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP09</accession>
    <name>D6SP09_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator, TraR/DksA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869807.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1844"/>
    <dbReference type="EnsemblBacteria" id="EFI34485">
        <property type="protein sequence ID" value="EFI34485"/>
        <property type="gene ID" value="Dthio_PD1844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="5">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="243" mass="28059" checksum="747F0AF5D6ACC86F" modified="2010-08-10" version="1">MLSKHSRAELYNKLFTRRMEILEKSKGLKDQWQEGNYAEKEMASRAQMDNMYRSINALDSQARSELNHIDHALDRMIIGNYGICDSCGQEISEARLQAVPWARYCRVCVNKAEEKTGPDTQEWEESPLPGTGSWESVSAEEFEEMSDEEILELVHERIHADAHIETHNLEISSIEGIVYLNGSIPNELQHNLLMGVLQDILPLENIRDNLHIESLTGLGWHTGEELLYRPDQMEEELFFNRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP57</accession>
    <name>D6SP57_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase with integral membrane sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1905"/>
    <dbReference type="EnsemblBacteria" id="EFI34533">
        <property type="protein sequence ID" value="EFI34533"/>
        <property type="gene ID" value="Dthio_PD1905"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="218"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="302"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="496" mass="54046" checksum="FD9533F4BC6A9AD9" modified="2010-08-10" version="1">MRLGLKIFLLLFVAAFTISGATGSYFYYQARQSLLESIQSQLLTAAKSFSGLISGDDLEALNSPEDMHSSAYPRIQRILHQIALTNEDFLFAYTMRIQDDEVLFVVDSPPSDDTGDGRISPDEMPEPVGAVYPDPPSSLLKGFVRPSVDQRIYQDQWGWTISGYAPIKDFRGRNVGLLGIDMCAEHMEAKLAAIRQAGLISLGVAGLLALGVTLLLTRHITGPIKSLHQGLSRVSAGDLDAVVPEHGRDELGDLSRHFNQMVGELREKQLLQSSLGKVMPREVVSRLLSDDPKLGGETAEACILFCDLRGFTSISEKLPPKILVGLLNDYFSAMVQAVEKQGGLVDKFIGDKLMAVFGHPITDEKAEAKALQAGVDMLSACDRLNSTLALTSDLILENSIGIHTGHVLAGNIGSPQRMEYTVVGDAVNIAARLEAKTREMHTRLIISSHVAAKISPLPGQLRSQKNISLEGRRETLDIYLLENSDPVGTRGRDSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPJ2</accession>
    <name>D6SPJ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multiple resistance and pH regulation protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869988.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2040"/>
    <dbReference type="EnsemblBacteria" id="EFI34668">
        <property type="protein sequence ID" value="EFI34668"/>
        <property type="gene ID" value="Dthio_PD2040"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2079593at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10006" checksum="1E123F3FD52AA02D" modified="2010-08-10" version="1">MQIFYLALASFLILNILAGLWRVIQGPTPADRMVSAQLFGTTGVAILLVLAQALEAPYIRNAALLFALLMIMAVLSFVRKTAPQQSQTGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPJ6</accession>
    <name>D6SPJ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sugar fermentation stimulation protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sfsA</name>
        <name evidence="4" type="ORF">Dthio_PD2044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SfsA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869992.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2044"/>
    <dbReference type="EnsemblBacteria" id="EFI34672">
        <property type="protein sequence ID" value="EFI34672"/>
        <property type="gene ID" value="Dthio_PD2044"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1375946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA_N" evidence="3">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SfsA" evidence="2">
        <location>
            <begin position="90"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="237" mass="26684" checksum="5869891C0ECB0406" modified="2010-08-10" version="1">MQRSKHNTVFLDTSCVQAVFQSREKRFTVHGLINGAAVAAHTNNSGSMMGLLRPGRDILLSPAANPARKLPYTLEMVHTGQFWVGVNTHTPNRMLRLAWQNSLIPELKGFEHFRSEAVIGDSRLDAVLHGTGGRLWIEAKNVTLMEEEKAYFPDAVSKRASKHMQELMLMAEAGYQTACFYLVQRPDCRCFGPADFIDPEFADVFRQAVRQGLMVLAYDTIIDPEGITLYRPLPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPP3</accession>
    <name>D6SPP3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870037.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2092"/>
    <dbReference type="EnsemblBacteria" id="EFI34719">
        <property type="protein sequence ID" value="EFI34719"/>
        <property type="gene ID" value="Dthio_PD2092"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2201799at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="28078" checksum="1E11EC6CD736BA22" modified="2010-08-10" version="1">MDRECKGCGRKPEPHEEMTMVAQWPFCPECFAKLMQKSEKTDTSKTSPRHEGEPAEVSDASTEAGNQAQNCEICGIALQGDTFSVGIWNFCRDCMQDLVASPALGNLQVPDQPGQEQDGSEQEDREEDEEALLHQQMLQSIPCAGCGRHIPLRGAKDAGGRLFCPDCFVSLESSEAEQSLGDVSPASTSAEAYSDHEAKSGSNSCESCGREVYSNRLQMEQGFAICSACLATDPALAVEIARSRHHRLMLHLRGEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPQ5</accession>
    <name>D6SPQ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion protein, VC_A0107 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870049.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2104"/>
    <dbReference type="EnsemblBacteria" id="EFI34731">
        <property type="protein sequence ID" value="EFI34731"/>
        <property type="gene ID" value="Dthio_PD2104"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1278805at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008312">
        <property type="entry name" value="T6SS_TssB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35850">
        <property type="entry name" value="PTHR35850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05591">
        <property type="entry name" value="T6SS_VipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03358">
        <property type="entry name" value="VI_chp_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="175" mass="20043" checksum="2FB36D62A2A66813" modified="2010-08-10" version="1">MAIQDEIPKSRLTLRYRTEINGQPQDVQLPLRLLVTGDYSLGSSKDRKLDLDERKMRNMDGRNTDAVMKDMGINLKFSVPNKIDPDKEEDMEVELPIESMKGFSPDQVAQNVPKLKGLLALKRLVQEVNSNIDNRKEFRKLLSDLISNPDALSKMQEELKAFENFKLPKGKAQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPT0</accession>
    <name>D6SPT0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870074.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2132"/>
    <dbReference type="EnsemblBacteria" id="EFI34756">
        <property type="protein sequence ID" value="EFI34756"/>
        <property type="gene ID" value="Dthio_PD2132"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="856739at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLA_N" evidence="7">
        <location>
            <begin position="834"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1518" mass="171535" checksum="FBF60A4D233FDF7B" modified="2010-08-10" version="1">MKQDPNRQEFESFIQMHDALQKTDLHLKGMHEMLYDAAGKCGPGCSLRYISYFFESDDTRPGQNRFWLILKLEREGTKIHVPATSFPCFTENGTLLFSGKSGAIQERRPIWQVVFRQEKDILPADWEEERKNLKENIQKYGLHPRWCRLSSLTHRLRYFLKKNLEKWKSRAVTNSYAASVLLAGSLDEAFYSTFYRRVDHFPLADTTNKLAETAQGRQVSAKSLRCHRKTMIGSKPEDNVRNLLPEHTGMICPVETPESESIGLVMHLARKARPELWSQDAAFNENDQRSEEGILKTPDPDNFLGYSACMVPYIQHTDPTRAMMGAKNMKQALSLTQGEAPLIRTGHEEEVFGRGEHDLDMDIGRNLLVAYLPWYGFNYEDGIVISRSAAEKFLSVKKHKFGPYFCPGNYRPANPDSKWRKLDRDGLAPQGQEVKSGDVLAAFYPVRWNHDSRSKKRQIVVNTLAEPLLVRVPDHVQGKLVRFEVVCLETSDLPLPRHITRMAVHMEIEESRPLEPGDKIMGRHGNKGVISRILPDREMPYFLDSMHGITDLRSSSHFHGEEQAHTHVEVILNPLGVIGRMNTGQLLECHTGLAMRCIPERMEFYQNSGMPFSSVDIESLRQDLLSTKIVDETGKARLFWRDEAGNHVQTGHASMIGVQYLMKLDHMARDKFHVCGKKPPRCMITNQPVKGRSRGGGLRLGEMENWCIIERQAWDVIDELLQKSEPDGQVSSNQALEDILYALGLELVCDDKSYVLRPHDQSYEHPQVSKPLSRAVNRKDAALDKTSYDQSIFGQESLKFLKKEARSGLSASGWGVIRLPFSVNHPLLDAYTSAELKISRIPVLPCRYRPLLKSDDERFITGTLDNIHDVLLELCSYYDGLETRKKEKLAQILKDIKEQDADIFSFVSKWLECRLDTKTSLLQVRQLGSGASKIKSRIKKICAAQTQKIQQKESSNAGLSVINEQLLSNQVFEARQKIICCLKIYYQYLVDLLQGKPGLLRGHILGRRFPLSGRAVIVPDPTLPLGRVRIPGAMYDEFFEHSDQENWILLNRPPSLLPSNIQAFSAQHGGSSKVIKLNPGLCAGFGADFDGDQMSAFALHAENALNQAESLMRPGAMPLAPKTGQPNLSMNLDIRLGIYLVQQAPEKLDELLTKYGLESTDKCSFFEQPDMEKNLKGLSKEKRESFMADVLWLCFKEATESGLSFSFFDLVQQHAKPARMDQDCEILEVDAYKAEYGDDPVSEANKKARKLVETSLHAKDNHSAIAILTKSKAASKLEQTTQLLHSRGGIRLPFDPAKNKAGVIHRSYTSGLHPADFFLSACATREAMMYKKLRTAHGGYFTRKLVEAGYQGAQVSGTEQGVFPEPFYEMQGFPAGLLSAHLLGEEGTQAAMKVFHTGQTENLDQISSVLKMIKAPPTSPEETVQMCRDIAAELNIKDGDNKKVFWSIVLQCLHKAGLGIEDLGPEQDNILAALSYGHVRKVLGRALTREHEHRTQMNLKEKFILYNRIRKLKEKQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPV4</accession>
    <name>D6SPV4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870096.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2156"/>
    <dbReference type="EnsemblBacteria" id="EFI34780">
        <property type="protein sequence ID" value="EFI34780"/>
        <property type="gene ID" value="Dthio_PD2156"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAV8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1375084at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024787">
        <property type="entry name" value="EcsC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12787">
        <property type="entry name" value="EcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="22089" checksum="83DAAE0FB12D3E5A" modified="2010-08-10" version="1">MQNNTDLDQGKMLQVLNWGYGKALNGVAGMSSASEIAEGYMNGNGTTLDKANSLVRWQCAKAGTSGFVSNLGGLMTMPVGIPANIASVIYVQIRMVVAIAHMGGYDIQDDRVRTLVYVCLVGNNAQQILKQAGVTLGRKVAQRAVNKISGRALIELNKKVGFRLATKFGERGIVNFGKAVPLAGGLVGGSFDYVTTKGVGKAATMIFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPZ9</accession>
    <name>D6SPZ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2213"/>
    <dbReference type="EnsemblBacteria" id="EFI34825">
        <property type="protein sequence ID" value="EFI34825"/>
        <property type="gene ID" value="Dthio_PD2213"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="12442" checksum="C8BB4A8696B4BBD2" modified="2010-08-10" version="1">MGFVVIFRIPEEKWLTPQDTPQATPQDAPQVEQLLEICIQPLSRQEMQDRLGLKDREHFRKYYLKPALDAGLIEQTIPQTPKSKFQKYRLAQAGRNYLQNMKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ28</accession>
    <name>D6SQ28_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA internalization-related competence protein ComEC/Rec2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870168.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2245"/>
    <dbReference type="EnsemblBacteria" id="EFI34854">
        <property type="protein sequence ID" value="EFI34854"/>
        <property type="gene ID" value="Dthio_PD2245"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1796527at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004797">
        <property type="entry name" value="Competence_ComEC/Rec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00361">
        <property type="entry name" value="ComEC_Rec2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="555"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="819" mass="92314" checksum="EB27822E4DB12D91" modified="2010-08-10" version="1">MVAQTLTPKGLLPWQKFVLAYVLGIWTLKYPLAGLAGLLLVLLFLPFRDVWRNMILAGVFMAAFLLAWFRLPDPPGYIPDPIQAQERVWLQGEVESVSYQPGDRQRLILKNLLIEPDREPVKLPGRLVFTWKDAPVEAAPGQKFQAHVNVRPVQGMANFGVWNSEFFWRTQGVFWRSFAEGEHFWHRVDREPGRSHVMRSRLKERTLQGLHLEGVDEEQRARIQAMGLALFFGDRSMLEPEVLEWVRLASLAHTLALSGLHLGIMAGMGFLLAAGIGYLYPRVYLRLPFMKLGILVAAPICIVYLWMGQFQPTLIRAGIMLACWGWYLFANQRRVLLDGLFMAAAAITLYNPWSVFDLRLQLSVMAVAGIALIIPLVERLFKNMEEKGVSRVFKYFLGLAGVTLAANVALLPIQAWTFNYFSPHLYLNLIWLPVLGFLVLPAGFAGVIVSTVPGLTFAGDILLGLAGHLLGYFISALEFMHSKDLLHPIITYRPAWVEIFAYYLLLGIIIHAGSIEWKKERVLLGLGLMLCLVIVPRAGQIQDESLTMRVLDVGQGQGIVLELPGEERIMVDGGGSWNPDFDLGRAVVTPSLTWRTRPQRLDKVVLSHAHVDHYGGLFYPLKYLGADKYLHNSIWPAEQDRLRLKKALDRQEVQEGVPGKGDVLEFDGAVALEVLHPGDPDKYELLNDSSLVVRLIWKGRPLALIPGDIEARGLEDLLDTEQDISARVLLVPHHGSRSSADPEFYRRVDPELAVVSRGFMNRFGVPHQEVRNIIRDLDISMYDTAVHGEVIFTWDSPDSDPVIRWARDRTGPGGVPYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ35</accession>
    <name>D6SQ35_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2252"/>
    <dbReference type="EnsemblBacteria" id="EFI34861">
        <property type="protein sequence ID" value="EFI34861"/>
        <property type="gene ID" value="Dthio_PD2252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="57" mass="6448" checksum="58E9E2AA82F20219" modified="2010-08-10" version="1">MMADFYFTGVARLKVGLATLLDFESLLYGLKKAAFPGMRQYKTRRIHETAFQSQTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQD5</accession>
    <name>D6SQD5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized conserved protein UCP018688</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2353"/>
    <dbReference type="EnsemblBacteria" id="EFI34961">
        <property type="protein sequence ID" value="EFI34961"/>
        <property type="gene ID" value="Dthio_PD2353"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1502336at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016732">
        <property type="entry name" value="UCP018688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41373">
        <property type="entry name" value="PTHR41373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018688">
        <property type="entry name" value="UCP018688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LPG_synthase_C" evidence="7">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="288" mass="33687" checksum="1AEF7F2CB90C048C" modified="2010-08-10" version="1">MQFYPIDLSLQDSYNRLLARTQQPVSDYSFTNVWGWSQEYGLEIAFDHELAWIRQDKPEQGFWAPVGDWNADWPRILDSFPRPARFIRVPEKLALIWKESLPGVEIHEAREHWDYLYSVPELKALKGNKWHKKKNLYNQFVKNNDYTYVSLDRKYIEFALGLQTEWCLWKECQESQTLEAENHVVVRVFNAWEELRGPFGAGIMVNGDMAAFTVAEALPDNTLLIHFEKGCPKYKGVYQAMNSLFLQNSAPDFEVVNREQDMGDPGLKKAKESYHPIGFLKKYTVVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQF8</accession>
    <name>D6SQF8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2376"/>
    <dbReference type="EnsemblBacteria" id="EFI34984">
        <property type="protein sequence ID" value="EFI34984"/>
        <property type="gene ID" value="Dthio_PD2376"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="5">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="233" mass="25687" checksum="3DB09A7AFC267990" modified="2010-08-10" version="1">MIQALSIVGYKKSGKTGLMLKLAKELQKRDIKVAAAKFSEHGFDQDNTDTAQMSSVVREVIGLSREQSFFHWQEKKYLPDLIPLLQAKMLLVEGGKHLGWLPRVLVLKKPADAEALDRGLAVATWGKIKTHYLPHAGSIQDLADIVQSRGFALPGLDCGTCGRETCLDLAREMVAGKAGIQDCQAMHSRMKVTVNNQELAMNPFVERIITKSIQGMLSELKGYSPGKINISIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQJ3</accession>
    <name>D6SQJ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/H+ antiporter MnhB subunit-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870333.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2412"/>
    <dbReference type="EnsemblBacteria" id="EFI35019">
        <property type="protein sequence ID" value="EFI35019"/>
        <property type="gene ID" value="Dthio_PD2412"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1962104at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="148" mass="15334" checksum="15DDB23F0E24EB9E" modified="2010-08-10" version="1">MITQSQSPIIEVVARGLAPVIQLLGIYVFFHGHYGPGGGFQGGVLLAAGVLLMRLGMGAVHSQAHVSSKTTVAICALGALIFAGTGLVAILGGGEFMDYSYLPVPGVEAVDLRYYGILFVELGITMAVMTGLVAIYDDLLGIKHAGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQS6</accession>
    <name>D6SQS6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2496"/>
    <dbReference type="EnsemblBacteria" id="EFI35102">
        <property type="protein sequence ID" value="EFI35102"/>
        <property type="gene ID" value="Dthio_PD2496"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="194"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="34131" checksum="81D21A52F2433C74" modified="2010-08-10" version="1">MQVEIQKDISLTPEDSIFLDMHSFYNIINIISGELQILEMMSGDERALQDCVDLCFRIKDGMSSRDSILEYAGSVEKHAAFIQDRLQEFLKSRPGLTDDPEVRESRANIDSVLDILRVRAGEIVNRLENPDKWEDHDLSRLMQNFLDVFSAIEKNSKGRYRFVYNLARQGPTDYFIHLNFQGTRQDSINMPPVLQDVMRDLVANARKYTEPGGKVLAGLYDDGKDIRFAVEDTGRGIPENEIENVVDFGVRGSNVQEKRTMGGGFGLTKAYSVVRQFGGRMWIDSAQDRGTRITLILPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQX5</accession>
    <name>D6SQX5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pre-crRNA processing endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870465.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2547"/>
    <dbReference type="EnsemblBacteria" id="EFI35151">
        <property type="protein sequence ID" value="EFI35151"/>
        <property type="gene ID" value="Dthio_PD2547"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z82V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619114at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010155">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029950">
        <property type="entry name" value="Cas_CT1134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01876">
        <property type="entry name" value="cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="218" mass="25192" checksum="95AE52D7243747C4" modified="2010-08-10" version="1">MAQGVQLRVWGDYACFTRPEMKVERVSYDVMTPSAARGVLEAIYWKPSICWKVDRIHVMKPILFDNVRRNEVESKIPVKGATGVNAAMKDSKTPLRLYIEDSRQQRAAMVLRDVEYIIEAHFEYTNGEDRNDGKHLDIFNRRAAKGQCFHRPYLGCREFAAFFEPVQGEIPQSALTGEKDLGWMLFDIDYQADMTTTFFRPVMKNGIIECRNQRVVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR30</accession>
    <name>D6SR30_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870512.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33146">
        <property type="protein sequence ID" value="EFI33146"/>
        <property type="gene ID" value="Dthio_PD0467"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZMSS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2039087at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9624" checksum="1EA26B8496571CF2" modified="2010-08-10" version="1">MIDTKHFTEMLKEREISMEMVDKTMTIPDKTEERKDGTKHYLKLFNVNGGRWLRVVINIKSDPPRRITAFFDRRLRRTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR81</accession>
    <name>D6SR81_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar hook-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870555.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0523"/>
    <dbReference type="EnsemblBacteria" id="EFI33197">
        <property type="protein sequence ID" value="EFI33197"/>
        <property type="gene ID" value="Dthio_PD0523"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1788350at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="6">
        <location>
            <begin position="563"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="645" mass="72060" checksum="8A95D4C4ABCF682D" modified="2010-08-10" version="1">MRVSHSMMYDNFMQNMNRSTTELMELNKQASSQKKVNKPSDDPVGMSRILGYRDSISALDQYQSNVDTAKGWLNLADETLMQASNLLIRAKELAEQGATGTLSPEQREILAGEVEQVFDQMLNLANTRYEGKSIFAGHKTDGSAFEKLEKGSVESNQDQLPDKLEVADDDTGSFVSGHLNEGVKVTFSKDEEYTLDPDKIVSEKGTDSERAKLEIDLGYPPPAGFKINELNLVDEDGSGINLEDSGFDSIHALVAALSGNDYIHDVEYIDSGEDKGKLIIYGDSGEEINVSGDFTLTEVTYQLETMDGKQISEDPQRLQWDEDRDAYKIQFSMEDDEENEEDQEQITIRFDPDFDPLDSGQISFDEDDDPKLWFMPTRPAVEYKGDDEDTNNFSVYAEKLEKDDVEVFGSFDKNVNLRIDKKIDEDGNVEGEDADYSGGDLARIEYSYSLDGGSTWNEGNTTTNNRFMVPGGRVEVEDDLDRLSTGDQINIRPHKASINFEISAGDNIQVNGIGKDIFGGIYKNSDGEYVKDPEGPENVFETLGELIGYLENDDEEGIQRSLANIDDTLKHISSELASVGARENRLDVASTVLSGLEHNEKERLSKIEDVDVAELMSRLMNQQMTYEAVLRSSSMIMQMSLVNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR91</accession>
    <name>D6SR91_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870565.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0533"/>
    <dbReference type="EnsemblBacteria" id="EFI33207">
        <property type="protein sequence ID" value="EFI33207"/>
        <property type="gene ID" value="Dthio_PD0533"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="168"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="352"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="458" mass="51989" checksum="CE28D6C5AC5323D5" modified="2010-08-10" version="1">MSESPENKARYVLERCADCDECRTMMTDVCPFFQELYRLFDDMQETGRSPGSKDLRLMVDRCNFCALCPCPEIRNRILDAKSSFIERDKMSPALKIIQDVEKWAGKMTRVPSLANLLLQGRLASNLLKKSAGLHPDRDIPRIPEQDLDSWTRKKGIADTSCADTPGAALFAGCSARFFFPEAARAAVGILQRNNISVYYPEQNCCAMPVMLEGDRDLTLKMMQRNLESLTRTLDAGHDIVCSCPTCGYMFRELLREKAYYSREYQEAAGANDTYMLVPRDNRPPPMDQREHKRLLRMIYGSIFKDDGLFSVFPAMQRIRVAESVYDMGEYLLGLYKKGSLDTDMAAVNKRAAYFPPCHLRKQGIGSPYVQLLKLIPGLEVQEIKGSNLCCGMAGIMGFKQDFHQPSLEMGRPLMQKVQDMQPDILLCDCLSCRLQFSHNLSIPLAHPLEVLYEASRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRF0</accession>
    <name>D6SRF0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870624.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0592"/>
    <dbReference type="EnsemblBacteria" id="EFI33266">
        <property type="protein sequence ID" value="EFI33266"/>
        <property type="gene ID" value="Dthio_PD0592"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="45"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="308" mass="33961" checksum="D9745FB29CB09E2A" modified="2010-08-10" version="1">MKILVSGSVAYDRIMPFPGKFADHIMPDKIHILNVCFLVDGLIEKFGGTAGNIAFTLKLLGEDPEILATVGKDFGNYEAWMQKHGISLESIRVMEEDLTASAYITTDKSDNQITGFNPAAMNHSSQFNFDRIAPEDTLAIVSPGNLDDMYNYSRKYQEKKVRYIFDPGQNIPAFSGEKMLDMISGSYILIANDYELEMIMKNTGKSKAELLEYTENIITTLGEHGCSVLNGGDDAVLPAARVSQVVDPTGAGDGFRAGLIKGLADGRSVSQAAKVGLTSAAYAVEHHGTQEHYFTPEEFWKRYKDNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRJ2</accession>
    <name>D6SRJ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="9">1.2.7.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870666.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0635"/>
    <dbReference type="EnsemblBacteria" id="EFI33308">
        <property type="protein sequence ID" value="EFI33308"/>
        <property type="gene ID" value="Dthio_PD0635"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332680at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="590" mass="65918" checksum="2ACE92597DFB5ECB" modified="2010-08-10" version="1">MTSSFKVMVVDLGKNKSSLEYFDARREWIGGSGLAAGLFSHFGLPGEDAFHPDQPLILAIGPLTGYFPLMSKTIMGFMSPYNNQYAESHGGGRSALALKFAGYDALVVRGKAEKPTCIGLGSREVHIQDVHFLKGMDIFKTGKKMRSLKPTNPGHRSILRIGPAGENLVRYACVNVDTYRHFGRMGSGAVMGAKNLKGIILSGDSHVDLDPDLSKEYNKVYKDIYNTVVQSGAMRKYHDLGTPENILPLNELQALPWRNMQSTYDENAGGISGEKFGQDQLLRQVACAGCPVGCIHIGLLRERFGQEHEYLYRQVSYDYEPIFGMGTMLGVDTAPGVLTLLEDVEKMGLDAISAGVALAWATEALQKKIITREHTLTDLEFGNVQAYREALDHLTRQPNEFYQALAGGTMKAAEKYGGEDFACVLGQEMAGYATGENYFVSQALGFRHSHLDTGAYGLDQEQDSRNIDKAIEYMQDQEDYRVLMCSMVGCLFARKAYPKENILRALNSLGYDYTQEELDACVEKIKHHRWALKFRTGFKPEDVKIPSRFKEITTWKGKTDPEYMDKLKSKYQEVLREMASAHEKRQGENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRM7</accession>
    <name>D6SRM7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen synthase</fullName>
            <ecNumber evidence="8">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glgA</name>
        <name evidence="11" type="ORF">Dthio_PD0671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870701.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0671"/>
    <dbReference type="EnsemblBacteria" id="EFI33343">
        <property type="protein sequence ID" value="EFI33343"/>
        <property type="gene ID" value="Dthio_PD0671"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="10">
        <location>
            <begin position="7"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="9">
        <location>
            <begin position="302"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="488" mass="55593" checksum="CC25FFA30F61789C" modified="2010-08-10" version="1">MYSPPDICFVASEIYPFSKTGGLADVLGVMPLTLHNMGYNVCVITPLYGRISTSAYSPRLVYEDLNVGYPWPGITTDVLQAEFRGMPVYFLDRGEYFDRRYYYCTYKGDYFDNCERFIFFCRAAMSLMKAFGKAPRIIHAHDWHAALVSPYLYYQRRTDPYWKNTRSVFTIHNLAFQGRFSVRLFWDCGLPYDAWSMDGVEFYDSFNLLKGGISYADRITTVSPSYAEEILTPEYGCGLESVLQKRSKDLVGILNGSDYDVWDPSKDRYLEAGYSSRDLYGKYLCKKELLETLCLPERLLSRPVLGFIGRFRSQKGIDLLIELMPDLVRQDVGIVVLGEGDAEYENELMNLVEAYPGHVAGIVGYTEEMAHKIQAGTDIFLMPSRYEPCGLTQMYSLRYGTPPVATAVGGLKDTIIPYPEENSTGFVFPEPTARSFWGAIQNALALYQDADAWKKMVVRGMHQDFSWSRSAREYARLYQELGDGTGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRR2</accession>
    <name>D6SRR2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870736.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0708"/>
    <dbReference type="EnsemblBacteria" id="EFI33378">
        <property type="protein sequence ID" value="EFI33378"/>
        <property type="gene ID" value="Dthio_PD0708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="8987" checksum="D5208D8F05A787B1" modified="2010-08-10" version="1">MKCFECGGEVLKTLGAVKMACPDGGFIIFKDIPMNQCRQCGEQYIPGKWAEKIGFMMRNRESLTPSEIIQVPVVTPASDACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRU1</accession>
    <name>D6SRU1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870762.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0739"/>
    <dbReference type="EnsemblBacteria" id="EFI33407">
        <property type="protein sequence ID" value="EFI33407"/>
        <property type="gene ID" value="Dthio_PD0739"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="14"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="145" mass="16118" checksum="30DE1966A9193320" modified="2010-08-10" version="1">MERIKKLSGTTVGIDTAPLIYFIEEKPPYLSVLEPFFAEMEKGSFLVSTSTITLLEVLVYPMRAGNYSLASEYKDILLHSKMITVEISHSISERAAGLRAKHNIRTPDALQICAAIETGADYFLSNDLRLPDIPSIKIITLDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRU5</accession>
    <name>D6SRU5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase orf1 for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870764.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0743"/>
    <dbReference type="EnsemblBacteria" id="EFI33411">
        <property type="protein sequence ID" value="EFI33411"/>
        <property type="gene ID" value="Dthio_PD0743"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2088406at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="113" mass="13314" checksum="8B9356124DF7BD32" modified="2010-08-10" version="1">MQTKSQKYTPEERAGFWSAHINKWRQGSLTKAEYCRRAELSKHAFYYWCKKLGHTYSRKTQEENAIVPVPLKVVQEKTHTPLRLMVNSYQVDIPGDFQQEVLAKLVRTLEEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS18</accession>
    <name>D6SS18_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid A 3-O-deacylase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0818"/>
    <dbReference type="EnsemblBacteria" id="EFI33484">
        <property type="protein sequence ID" value="EFI33484"/>
        <property type="gene ID" value="Dthio_PD0818"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50341UQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018550">
        <property type="entry name" value="Lipid-A_deacylase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09411">
        <property type="entry name" value="PagL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="206" mass="22908" checksum="427D44EA05064AFE" modified="2010-08-10" version="1">MAQSHWSIDRLRDAWLYVPLLCLFAVFSMIVAPGLANAEEQERSEVVEPRYGMGLGVALAYDPSDARDFATVTGFALYDYDAIWPHRAPESLRFKVEGSLGGTLRSPPEILASVGFLALYYLDGLSSRFVRPYIEGGVGLIYTEYKVKEQGTRLNFNPQAGVGIEFAGDHNLQPWMSVRLHHLSNAGLSSDNRGVNSLVINMGWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS42</accession>
    <name>D6SS42_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gpmI</name>
        <name evidence="14" type="ORF">Dthio_PD0842</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870860.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0842"/>
    <dbReference type="EnsemblBacteria" id="EFI33508">
        <property type="protein sequence ID" value="EFI33508"/>
        <property type="gene ID" value="Dthio_PD0842"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338375at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="7"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="84"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI33508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="514" mass="57077" checksum="E439190B0F5B5116" modified="2010-08-10" version="1">MHNNRTPVVLLILDGWGLAPQGPGNAFSRAHTPNLDLIMNTYPCTSLECSGPQVGLPRGQMGNSEVGHLNIGAGRVVYQDILRISLTLEEGRLGQNPVLEDLLNRMGPESTLHLMGLVSDGGVHSLQEHLHGLLNILGQKNVSRVMVHCFLDGRDTSPTSGAHFVSRLQEYMESCGTGRIATVMGRYYAMDRDKRWERTREAYEALTLGRAEAVRDPVQAIQASYSRGVTDEFVKPMVLTDEDNHPVGCLQDNDAVLFFNFRADRARQLTQALYRRDFQEFTRSKAPDLSVATMTEYDKSFGLPVLFPPENLQNILGEVLSNNSIAQLRIAETEKYAHVTYFFNGGLEEPFQQEERVLIPSPREVATYDHKPEMSAFQVTEKLCSLIRQEKYNLYVCNLANLDMVGHTGNIQAAVKACETVDRCAGSVLEAVLEKNGILLLTSDHGNSEDMLAENGSPKTAHSTNPVPFCLVNCPGQELRREGMLADIAPTILDLWSIDLPAEMDGKSLLYKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS93</accession>
    <name>D6SS93_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870909.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0893"/>
    <dbReference type="EnsemblBacteria" id="EFI33559">
        <property type="protein sequence ID" value="EFI33559"/>
        <property type="gene ID" value="Dthio_PD0893"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1234999at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="93"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="240" mass="28021" checksum="7436C12BE7DB00D4" modified="2010-08-10" version="1">MKYITFYFHRELREHFGLKYPLEYVLQRRASIKDIIEALGVPHTEVGEIIADEREAGFDHIPSPGEKIVVRSVEAPVDVASSTRLRPEAWPETRFIADVNVGKLAMLLRMLGQDTLWDNSYSDRQVAVLAARERRIVLSRDRGLLKRKEIMHGRLIRACNPDDQLREVARIYGLDLTCSFSRCLRCNQVLEPVPKSEIIQRLKPRTRKYFDYFEICPGCERIYWRGSHWEKMCSRIQDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSA9</accession>
    <name>D6SSA9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Signal peptidase I</fullName>
            <ecNumber evidence="5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870925.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0910"/>
    <dbReference type="MEROPS" id="S26.025"/>
    <dbReference type="EnsemblBacteria" id="EFI33575">
        <property type="protein sequence ID" value="EFI33575"/>
        <property type="gene ID" value="Dthio_PD0910"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="201" mass="23852" checksum="E4ABA094CFD91D77" modified="2010-08-10" version="1">MNPRWHKLLKEYAEALIIALILAIFIRTFVVQAFKIPSGSMLPTLEIGDHLLVTKFSYGIHMPFMDRYIFEFDGPEFQDIVVFEFPENPSKDFIKRVIGTPGDEIFIEDKEVYINGDRVQEDYVQHADQRVMNSRDTFGPKEVPEGKYFVLGDNRDQSYDARFWDDHFVEREKIIGKAWRIYWSWEGFSNIRWDRIGSRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSH2</accession>
    <name>D6SSH2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0973"/>
    <dbReference type="EnsemblBacteria" id="EFI33638">
        <property type="protein sequence ID" value="EFI33638"/>
        <property type="gene ID" value="Dthio_PD0973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="9959" checksum="49CADBE492A3DF2D" modified="2010-08-10" version="1">MFIRKGAHTTTPDPSLAKEGSYTVPWTYLGGESLIKIQTQNLYRCMRQNVATPQSAPLKKYGSRGVWEYGSKNIFTPTHGYPHTPILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSH4</accession>
    <name>D6SSH4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KaiB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870989.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0975"/>
    <dbReference type="EnsemblBacteria" id="EFI33640">
        <property type="protein sequence ID" value="EFI33640"/>
        <property type="gene ID" value="Dthio_PD0975"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1999883at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02978">
        <property type="entry name" value="KaiB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039022">
        <property type="entry name" value="KaiB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011649">
        <property type="entry name" value="KaiB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41709">
        <property type="entry name" value="PTHR41709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07689">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01248">
        <property type="entry name" value="KaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12600" checksum="97C1590C175BEB32" modified="2010-08-10" version="1">MSDQNQEPDDDMRQQDTDSGMWNLRLYVAGQSSKSLTAFANLKALCEEHLQGRYTIEVVDLIENPQLAKGDQILAVPTLVRKLPPPLRKIIGDLSDTDRVLVGLDLKQHETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSL6</accession>
    <name>D6SSL6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871031.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1019"/>
    <dbReference type="EnsemblBacteria" id="EFI33682">
        <property type="protein sequence ID" value="EFI33682"/>
        <property type="gene ID" value="Dthio_PD1019"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="121" mass="13898" checksum="A85743E26A9F72E8" modified="2010-08-10" version="1">MWELFLASSTVEQELMELPPEMKARLLKVAELIKTHGLPNVGMPYVRHIQDELWEIRLAGKDAIGRGLYVTLAGKRIVILRFFVKKTRKTPGKEIRTALERLRSISDETLRGIEGRNSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SST7</accession>
    <name>D6SST7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Selenocysteine-specific elongation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">SelB translation factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871102.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1092"/>
    <dbReference type="EnsemblBacteria" id="EFI33753">
        <property type="protein sequence ID" value="EFI33753"/>
        <property type="gene ID" value="Dthio_PD1092"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015190">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004535">
        <property type="entry name" value="Transl_elong_SelB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09106">
        <property type="entry name" value="SelB-wing_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00475">
        <property type="entry name" value="selB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="635" mass="71811" checksum="72BA98F1A28E7C6E" modified="2010-08-10" version="1">MPVIMGTAGHIDHGKTTLIKALSGMECDRLVEEKKRGITIELGFAFMDLEPGMRLGIIDVPGHERFVKNMVSGASGIDFVLLVIAADEGVMPQTREHLDVCTLLGVETGLVALTKTDMADPEWLELVQEDVSDYLQDTFLKDAPVVPVSAHTGQGIQELLGHIRQMAGEFKPHRRSDLFRLPMDRIFTMRGHGTVITGTTVSGRIKVGEEVMIYPQEITSKVRSLQVHGEQTQESQAGMRTAVNLHGLEVEDLERGFVLGKPGTLFPSRAWDLELTHLESAPRPLKHRTQVHFHHGAKEVLARIYLLDRDKLEPGERCVCQVRFEDPMAGVYGDRCVIRSYSPLRTIAGAGIINPLAGKVKRFSSQVQTLERLARARAEELIQVQLEIAGSKGLSLAQLVILTDLESKELQKKLQLMGGRQEVFLVDKESRIYVAGEVVKRLEESMLAELQELHRRFPMRQGVSRGELAGKWARDIPEKLFFFVLERLVRAEKIVSEQEYYRLPQHKVSLAADQEKLREKITRTYRQAGIQPPTVKKLLEELGLEMKEAGPVLRLLQDEKELVKINEDFYFSAGAVQELKDKVKDYLEKNEEMGPVEFKEITGLSRKFAIPLMEFMDKEKLTMRVGDKRKLRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST36</accession>
    <name>D6ST36_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871201.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1191"/>
    <dbReference type="EnsemblBacteria" id="EFI33852">
        <property type="protein sequence ID" value="EFI33852"/>
        <property type="gene ID" value="Dthio_PD1191"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029119at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NfeD" evidence="2">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="128" mass="14558" checksum="8048ED8342324846" modified="2010-08-10" version="1">MTPLIRYVALQVPGFLIALILLMHARDQEWISVSTVVLVLAILVFKDVILYPFFRRAMQPGHTDMVARLHGERARVVNTLDPEGQVKLKGEIWNAKSIHGEPVEAGSWVRVSGHRGLKLHVQRCHEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST57</accession>
    <name>D6ST57_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-4 C11-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871222.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1212"/>
    <dbReference type="EnsemblBacteria" id="EFI33873">
        <property type="protein sequence ID" value="EFI33873"/>
        <property type="gene ID" value="Dthio_PD1212"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="28082" checksum="69E0D2E8C1ACB064" modified="2010-08-10" version="1">MTNYPIKFVGAGPGDPELITVKGSRALQQADLIIYAGSLVPDAVLHWAGHDARRISSADMHLEDIVDSMTQAHFNGLQVVRLHSGDPSLYGAIFEQISALEKARVPFEIIPGVTAAFAAAASLQIEYTLPEICQTLILTRAQGRTPVPDSEHLQSLASHKAAMAIYLSSGLAEQVQPILQEAYGPRARAAIVHRASHPDEKIIRTTVSDLAWQMQEHGIKGQALIIIGAALEDSPQRPASRLYDPQFTHGFRKGRQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST76</accession>
    <name>D6ST76_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871241.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1231"/>
    <dbReference type="EnsemblBacteria" id="EFI33892">
        <property type="protein sequence ID" value="EFI33892"/>
        <property type="gene ID" value="Dthio_PD1231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1683794at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="174" mass="18888" checksum="B13C89C1D49C5B95" modified="2010-08-10" version="1">MENLEYERLAWAVLFGHIAIIVVGGFMTVLSQSLVRALVGLIMTLFGVAGLFFLMAAPFIALMQILIYVGAVSVLIFFAIMLTNAWPGGDETGRSPGRKYVYAGLAGLVPAVMLATAAIRSAPPSFLVPEETEISVLGRFFLEDFILPFELISLLLTIAMAGAVILAFEMRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6STC7</accession>
    <name>D6STC7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="6" type="ORF">Dthio_PD1282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871292.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1282"/>
    <dbReference type="EnsemblBacteria" id="EFI33943">
        <property type="protein sequence ID" value="EFI33943"/>
        <property type="gene ID" value="Dthio_PD1282"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="16091" checksum="F5C27E99C88EE400" modified="2010-08-10" version="1">MILVDTGAWLALLDRRDASHGLCCDFFRNNREPLMTTWPVLVECVHLMFGRIGVSKTLAWLHTLESQGVGIFVMEASHFPRVIALMNQFRDLPMDLADASLVLLAEESGEGRIVSTDERDFHAYRWKNQYPFRNLLLEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6STJ7</accession>
    <name>D6STJ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1352"/>
    <dbReference type="EnsemblBacteria" id="EFI34013">
        <property type="protein sequence ID" value="EFI34013"/>
        <property type="gene ID" value="Dthio_PD1352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="38"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="353"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="605" mass="68041" checksum="2317D5C758B4FC61" modified="2010-08-10" version="1">MEDDSKKDKVKYNKPKGDTWPLVKRCLGYFVPYKIYIIVSLLSLLAVSGATAAAAFLVKPALDDIFIAQDERALMVIPFLLFMAVMVMSVFQFLQKYLMNYCGLKVLQQLRNELYYKFTGLPVNFFDHNRVGMLMSRIVNDVNLLRASLPHFIDLIRDFLTMLGLLVVVFYQDAFLATISLVIYPLAVYPFIHFSNKIRKLGRKKQVKLSQITGFLQETLSGIKVIKAFAAENREHQNFAKENQKLVANALKQLKYNSLATPVMEVLGAVGMGLIIWYGGSQVMAGETTPGTFFSFLTALFMLYQPIKKLNKTNLQIQQALAGAERVFQVLDSDEIKEEKGGDVELRPPFESLEMKNVSFYYPESQHPALDRVNLNIIQGQKIAIVGPSGAGKSTLINILPRFYVQQEGEVYINGRPTSEYTLHSLRRFMGIVSQDNFLFNTTVSENIAYGLDHAEPEQVEAAARAAFAHDFIMELSDGYDTVLGERGVRLSGGQKQRITIARAILKDPALLILDEATSALDTESERIVQQALENLMRQRTSIVIAHRLSTILSADSIVVLDQGSIISQGSHEQLLHKCSLYKKLYEMQFQDQNAGLEVDAGERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6STL0</accession>
    <name>D6STL0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871375.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1365"/>
    <dbReference type="EnsemblBacteria" id="EFI34026">
        <property type="protein sequence ID" value="EFI34026"/>
        <property type="gene ID" value="Dthio_PD1365"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50332M2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1478583at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="231" mass="27381" checksum="3641F537077AD0ED" modified="2010-08-10" version="1">MQLFYRQKMRRHDKLCSDILSSLNMRVNPRDIRYFAKYRPWQRKLRFLEKIGLKSIYHFIRNDKKIIITGGLKPRLFSEHFKYIFLKELWDNNLDYTCTKRFKLFKDRIDAGKEIVMPVKGYRLKNLEDLESYFQDYVRLLESMSAEGFLAQKSNDELLVIIGEKGELIKTSRGRHRLAAAQITGIESIPVRVRHIHQSWVEMQKAGRAGKEGLAEDIALSMQKVREMYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6STW6</accession>
    <name>D6STW6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871481.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1474"/>
    <dbReference type="EnsemblBacteria" id="EFI34132">
        <property type="protein sequence ID" value="EFI34132"/>
        <property type="gene ID" value="Dthio_PD1474"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="389" mass="43884" checksum="908637395BC78F5F" modified="2010-08-10" version="1">MAEFARINRLPPYVFAIVNDLKMQLRRQGEDIVDLGMGNPDLATPQHIVDKLVEAASKGVNHRYSASKGIPNLRKAICDWYKRRYDVDLDPETEAIATMGAKEGLSHLALAMLSPGDVVFSQDPTYPIHPYSAIIAGADVRRVPIGLDRDFFEDLLTATRQTWPMPKLLIICYPHNPTTAVVDRDFFQKIVDFAREHNIRVIHDLAYADLSFEGYTPPSMLEIPGARDVGVEFFSMSKSYSMPGWRMGFCCGNKDMVHALTRIKSYLDYGIFQPIQIASIIALNGPQDCVQDIVNIYKDRRDALVEGLNRIGWKVEKPKATMFVWAKIPEEFRKMGSVEFSKLLLQEGKMAVSPGLGFGHYGDDHVRFALVENRHRINQALRGVKKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6STX8</accession>
    <name>D6STX8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871493.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1486"/>
    <dbReference type="EnsemblBacteria" id="EFI34144">
        <property type="protein sequence ID" value="EFI34144"/>
        <property type="gene ID" value="Dthio_PD1486"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1555988at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="644" mass="73355" checksum="95757DDEFAA5A2FB" modified="2010-08-10" version="1">MSASGNNGLNAYAEALKKKDFARAEKIARKLLKKNPGDGRMLKYLGTVQAIQGKNAEALPRLEQAAGLLPGDAELLKNLAQNLEAMGRDEEAARRYLQMLDISPDSPSIHVRLAAIFGRAKNLHQARDHARRASELDPHNWDALMKLARAHHELEEPQKAKRLYQKVLTMNPEHPPAYSSLGSVCRELNNPEEAREHLQRALELEPDSALHHTRMGSVCKDLKLYEEARDHYLRALEIDPHFEHAHSRLGNAYKHLGQISDALKSYRRALELDPDSVQAHYGLSELTTFDDPDDPAIKRLQARFMDSETDPHDRALAGFALGKAMLDQKRLSEAFDCYDQANRIMYPLREGGPDWDIRPARYQRLFSGEFMARAGDFGLQETPQVFVVGFSRSGKSLVESLIACHPDIEPWGEDQKFHRFCRGKGKNYLQKLTPEKSRQEARNYIREHQFPPGRGRCVTTLPGNITVLGYLGLYFPATPIIFVQRDLKDLGVSCYFKHYARGNRYAFDLEHLGREIRLYRELIKHWTQVLPNPMLMLSYEELTRNPDGMCSMLYSFLGLEWKKEYFKVLKERSSHVLDLGPAHSLDLAMPIRKDFVGFSEPFRDRLGPLLQGYRNALQDTRYDQPAGKVLAAGKAAGRKKMAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU20</accession>
    <name>D6SU20_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Virulence protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871803.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0426"/>
    <dbReference type="EnsemblBacteria" id="EFI33111">
        <property type="protein sequence ID" value="EFI33111"/>
        <property type="gene ID" value="Dthio_PD0426"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1838027at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="170" mass="19904" checksum="2DB8742CC67C2728" modified="2010-08-10" version="1">MTNEIILYSTPEGNKKVGVLYHDESFWMTQKAIAELFDVEVPAISKHLGNIYDSGELEREATISILETVRREGNRNVKRKLEYYNLDAIIAVGYRVNSYQATQFRVWATKTLKEFIIKGYVLDDERLRQEKHYGSCADTVILPISRRKRLRPSWNRRRFSAGSGWLYDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU68</accession>
    <name>D6SU68_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0155"/>
    <dbReference type="EnsemblBacteria" id="EFI32848">
        <property type="protein sequence ID" value="EFI32848"/>
        <property type="gene ID" value="Dthio_PD0155"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="345" mass="36655" checksum="DAC4420DEA056B7B" modified="2010-08-10" version="1">MEQKVTISAVRNISKQILIHVGVSPEHTEIIVDSIVYAHQSGKGTHGLGRLPLYVKKIQAGFMAAETSTDLVKDTPVLAVMDAKNGFGQVAATKAMDLCINKANYYGIGLVGVRRSNNFGTASFITEQAAAKGMIGIVLGNSGPAIAPTGGSHPLFGTNPLGIAFPNPVGEFPISLDMATSVVARGKVRQAAKSNEKIPFGWALDGNGQPTCDPFQALEGSMIPIGDHKGYGLSLAIDILAGLLTGSAFGGDVHPLGDMSANSNYGHLCMTINVDFFMTIDEWSQKIAYLVSSIKSCGDPEKIRIHGESSHRSIRNSKEYVLVKNRVINDIESSASSLGIEVRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU76</accession>
    <name>D6SU76_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0163"/>
    <dbReference type="EnsemblBacteria" id="EFI32856">
        <property type="protein sequence ID" value="EFI32856"/>
        <property type="gene ID" value="Dthio_PD0163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="172" mass="19597" checksum="AAEDE0B43D3EDD98" modified="2010-08-10" version="1">MGNSALSLPISCMACFGQLSTSFTHFKQCTNWATHRLLPGIYLPHFMHGILWAIKATLYPFQTRYTLGNSAPSLPISCMACFGQFSTSFTHFRQRTNWATHRLLPGIYLPHFMHGILWAAYFTGKRTAFHSKVDSVPWEKGQHSMLMMDSHSTARWTAFHGKMDTFTMNSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUN5</accession>
    <name>D6SUN5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ORF">Dthio_PD0329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871708.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0329"/>
    <dbReference type="EnsemblBacteria" id="EFI33015">
        <property type="protein sequence ID" value="EFI33015"/>
        <property type="gene ID" value="Dthio_PD0329"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="397" mass="43660" checksum="A84A821DA30B111B" modified="2010-08-10" version="1">MGKSKFDRKKPHVNIGTIGHIDHGKTTLTAAITKVLSMKGSGQFVAFDQIDKAPEEKERGITIATAHVEYETPNRHYAHVDCPGHADYIKNMITGAAQMDGAVLVVAATDGPMPQTREHILLARQVGVPSLVVYLNKVDLVDDPELLELVELEVRELLSKYDFPGDDVPVVRGSALKALETEDSESEDAKSIWEIVQACDDFIPEPQRDIDKPYLMPIEDVFSISGRGTVVTGRVERGIIKVGDEVEIVGINETRKTVCTGVEMFRKVLDQGQAGDNVGVLLRGIKRDDVERGQVLAAPKSIKPHRRFKAEVYILNKEEGGRHTPFFSGYRPQFYFRTTDVTGVVTLPDGVEMVMPGDNTTFDVELIVPIAMDPGLRFAIREGGRTVGAGVVSEIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV01</accession>
    <name>D6SV01_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0046"/>
    <dbReference type="EnsemblBacteria" id="EFI32757">
        <property type="protein sequence ID" value="EFI32757"/>
        <property type="gene ID" value="Dthio_PD0046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="33" mass="3666" checksum="01AE4564A4871175" modified="2010-08-10" version="1">MSNGSVICKVISVIANIISECLREDQNNKDKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJS4</accession>
    <name>D6SJS4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869252.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3580"/>
    <dbReference type="EnsemblBacteria" id="EFI36127">
        <property type="protein sequence ID" value="EFI36127"/>
        <property type="gene ID" value="Dthio_PD3580"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="431" mass="47793" checksum="DD243A4C7ABB0BB5" modified="2010-08-10" version="1">MKICMFTNTYLPHVGGVARSVDFFAQDLRKMGHEVLVIAPTFPGLSPGVEEEGRVLRVPALQNFNGSDFSVRLPLPFTINRQLEKFRPDIIHSHHPYLMGDSALRMAMQHDLPLVFTHHTLYERYTHYVPLNSEKMKRFVVELSTMYANMCSMVVAPSESIALMLEERGVKAPIEVIPTGVDLDFFAAGDGQAFKEECGLEKARLIIGHVGRLAPEKNLEYLSRAVALYLQKDPGAVFVVVGDGPSREDIRDIFQEKGVLDRLVLAGQKTGQDLADAYRAMDVFVFSSTTETQGMVLAEAMAAGNPVIALDASGTREVVRDGENGRLLDAQSSEHEFAGALEEFAGDKSRQQEWMQNALKTAASFSRESSAESMAGLYERVIKSFVQKDTWASHELVSWDSVLKGIRAQWQLLSHKTKAAVSALKQEGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJX6</accession>
    <name>D6SJX6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger C4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869301.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3635"/>
    <dbReference type="EnsemblBacteria" id="EFI36179">
        <property type="protein sequence ID" value="EFI36179"/>
        <property type="gene ID" value="Dthio_PD3635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="6739" checksum="A06E7D5459140F24" modified="2010-08-10" version="1">MRSCSFCGKNEVQVQTLIESALTHSAACETCALYVYEDALEALAEQANAANIDIEESQKGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJY3</accession>
    <name>D6SJY3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869308.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3642"/>
    <dbReference type="EnsemblBacteria" id="EFI36186">
        <property type="protein sequence ID" value="EFI36186"/>
        <property type="gene ID" value="Dthio_PD3642"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1006904at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="378" mass="43604" checksum="1DD9737E54CDF645" modified="2010-08-10" version="1">MLEHTIQFKRTLWDKKGSWIPLTLQNLPSELRSRINPVAFTDGYEAVWLTPRVYDNQGNIHYLPWLDVEHPEKHHTSIQANIDTGKSLYLKLDSMGLANGLHILLSGNGLRFIWGFIVAPEWGRGFITLIKDSSSFPGIDHSPLTWANMWFRFLGYRGNQKQEDKNISNCHIHLLSHPRELLDLTEQQYLELVKGKPDYEICMQWADQILPVEYELPAPWKAILQQYDLMARLRTHIIKIGFPRPQKSAVKTDWEQIHAALNNLGIKVLRERTVYETTIFQLSSCPACGQTEGNPWLTESGILKCWRANNCPAGQDRYNQKSGLYFTGLYPQEWIEGYHFEEIEAESHTTEARGVVTIDEARKRIADVFREAGCNANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJY8</accession>
    <name>D6SJY8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3647"/>
    <dbReference type="EnsemblBacteria" id="EFI36191">
        <property type="protein sequence ID" value="EFI36191"/>
        <property type="gene ID" value="Dthio_PD3647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="46" mass="5275" checksum="0BCA435B021A6B6E" modified="2010-08-10" version="1">METVDAKEMSGHADIAMTDRYSHLTAQHKFLIQAQLQKYYDSQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK32</accession>
    <name>D6SK32_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869357.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3692"/>
    <dbReference type="EnsemblBacteria" id="EFI36235">
        <property type="protein sequence ID" value="EFI36235"/>
        <property type="gene ID" value="Dthio_PD3692"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="25221" checksum="8A801AB35A12943C" modified="2010-08-10" version="1">MNNWIFLSYPLNPQAPAYGGGHGFAEKKVKQMDHGDSCDTKSWSMSNHIGTHIDFPRHFSTRGKDIDDYDPEFFIFFQVFIADISPAEPELIITPDHLDISQAPADTDLLLIKTGFGGLRGQDIYSQDNPGFHPDLADYLRERLPALRVFGFDSISLSSYAHRDLGREAHRAFLLDNNHPILPLEDMHLEQIDGHTEIKQAIIAPLRVTGADGAPCTVLAKVKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKI5</accession>
    <name>D6SKI5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868330.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2603"/>
    <dbReference type="EnsemblBacteria" id="EFI35196">
        <property type="protein sequence ID" value="EFI35196"/>
        <property type="gene ID" value="Dthio_PD2603"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033MY1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2076572at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8369" checksum="F81B02FF364C7C31" modified="2010-08-10" version="1">MTLTKEIPDRELIIKGTEVLYKELGYVDTIRFLSMPRGQRVESVERHRKWQESLDMKIFYDEAFKSDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKI6</accession>
    <name>D6SKI6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2605"/>
    <dbReference type="EnsemblBacteria" id="EFI35197">
        <property type="protein sequence ID" value="EFI35197"/>
        <property type="gene ID" value="Dthio_PD2605"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="297"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="446" mass="51178" checksum="A8DEACA73F49A2EA" modified="2010-08-10" version="1">MRKVFETQPQFFHLMPSNKLGKMLEKISDILFENKQVLKSIFNDIAADKNYTVGRNGLNADQVLRCAVLKMLMNFTYERLEFHLSDSQAMRAFAKLDYNQKPGKSSLQANIKSISEDTWEKINKALVKYSLDTKIETGNMTRTDATAVDTNIHKPCDSTLLQDGIRVITRILQKTKELCPGVKFSDHNRAAKKRVLNIMHAKDKKREKAYKKLLGLARNVVQYADQAHAELKAYNDPDFEKKLLAENLKEQLEYNLDMLHQVMDQTVRRVINKEKVPSEEKLISFFEPHSDIIKKARRETQFGHKVYLTTGKSGLILDCMMPRGNPNDSSLVEEIVERQKKTLDKTPRKIAMDGGFASQNSLDKAKEAGVKDVCFAKKRNLNILDMVKSSYVYKKLRNFRAGIEAIISTMKRAFGLDRCTWQGWEGFKQYVWSSVVAFNLQIMATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKS7</accession>
    <name>D6SKS7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fimbrial assembly family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2702"/>
    <dbReference type="EnsemblBacteria" id="EFI35288">
        <property type="protein sequence ID" value="EFI35288"/>
        <property type="gene ID" value="Dthio_PD2702"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="428" mass="47254" checksum="9367BB06B677BDEB" modified="2010-08-10" version="1">MLEKLLAPFCTWESIIFVLPDRVLVRRAGRGLPGRIAGVFEQEYDLGPEGDLSTVLSLARTSMPSGSAGLCMLGLPLRHFSLASFTLPAAAARNLDEAVRYALMRHLPYDPEAARITYQSREDGERLDIFTLAIPDKALSAFLKAAASAGMTVQEVFPSLLYWARKKGEGIYVSLSAGYSEILVHSGARGFLHTWAEDEDLFVQEAEKLLSSMPHLPADLYLWGARDDAGAILDRMGLKPGKAVALNLAHVRDDHGDKFLQGISIDVLPLKIRRQQKMATYLAVIGLAFFLLAVAFWPLGGYLGHKRYLAGLEQKIAETAHMAQEQRELAEKNLELKEKITALVNRQKAYPQALEILAEVTRVVPDTAWLSSFACFETQVDIQGEADSATAVLEAMEDSFLFSRVRFSAPVTRTGERDRFSLEAVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKT5</accession>
    <name>D6SKT5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.33" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868428.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2710"/>
    <dbReference type="EnsemblBacteria" id="EFI35296">
        <property type="protein sequence ID" value="EFI35296"/>
        <property type="gene ID" value="Dthio_PD2710"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183:SF1">
        <property type="entry name" value="PTHR47183:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="29118" checksum="991FB07D14B8D9CD" modified="2010-08-10" version="1">MKAIILAGGLGTRLSEETTVRPKPMVEIGGMPILWHIMKIYSVYGVNEFIVCCGYKGEAIKEFFADYFLKRSDITCDLKHNKMTIHRNDVEPWKVTLVDTGLETMKGGRMLKARQYIGNETCLMTYGDGVSNVDITGLLEFHKKQNVLATLTAVQPPGRFGAFRLGKDQYTISSFKEKPDGDGAWVNGGFFVLEPEALDYIEGEHIDWENEPMERLAGEGKLAAYKHSGFWQPMDTLRDKNLLEKLWQSGKAPWKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKW1</accession>
    <name>D6SKW1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2737"/>
    <dbReference type="EnsemblBacteria" id="EFI35322">
        <property type="protein sequence ID" value="EFI35322"/>
        <property type="gene ID" value="Dthio_PD2737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="67" mass="7917" checksum="4FA50D6A89B47D59" modified="2010-08-10" version="1">MSVRCDCKKSFLSREPRQPHEARGRTRDRSQILVRPTRPEPEDKDFLINGSDIRVINNWQICLADKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKW9</accession>
    <name>D6SKW9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868462.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2745"/>
    <dbReference type="EnsemblBacteria" id="EFI35330">
        <property type="protein sequence ID" value="EFI35330"/>
        <property type="gene ID" value="Dthio_PD2745"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="230"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="321"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="442"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="584"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="827"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="949" mass="107806" checksum="1DCEA0D55DD2E6B1" modified="2010-08-10" version="1">MPDEISRNDITKIATALLESRDMDSLLCHCLPLFMELSKCSIIGLYSKGKQDMYHVSADPSVFLENPRKTCQHILARMEIGADEPWPGTLCQNLHCYGFKLQGKWRLLVCKLRPFSPDFFQDFLELVDLMGKSRIFCEDESTVQVSSERLQKLEQTEKIFLHLVQYIPSVFWLREKNRMLYVSPGYEMIWGRPLDALFNDMEHFYRSVHVKDLDWAFKCLHEDFFSKHSIELEFRIVRPEGAVRWVRIRSYPIFEDGSVVRRAGIAEDITSEKAMLGELDRYRFHLDEMVKEKTVRLSCLNQILENDVEDRKKLHKKLIKSNALFRSFVDSFIHPALLVDFDGTILALNKAVARAFGTTPDKIAGCSAFKFLEWERFEYFMVKVQEVLCTGKPLRFNENVGNVHFDVQVSPVVEPSGKAFQAVFYLNDITEVVQAEEELHRSWARLCAVVDSMPVLVHAHDEAGNFVFWNKESERVLGYTAEEMLNNPDAFEILYTEKGLRKKALKCWADYDGKTPCTLEVKDKSGCIKTIEWHRLSSNYPIAGWKDWEAGLDVTEKKAGERQLLKAIAETEKANQLKSRFLANISHEVRTPISGVIGLSSMLLKTSADDDQKRMIQNIANLSEYLLQIINEILDFSKLESGSYSLEQHDFDLDSMFESIAAALCSQVQEKNVEFKVLIEDDVPVHLRGDGYSLKRILVNLTANAVKFTDAGNVILRASLLNRSKDRLEILFVVFDTGVGVPAAIQETIFEPFTQAEGGFSRRYGGTGLGLAICKSLVEMMGGHIWMESTPGEGSSFFVRIPFEPAEASLQISSVQSGQVPEVRNLKILLVEDFPVNQEIIAHILREQGHDVTIKSDGREALEDLEQGNRYDLVLMDLQMPVMDGFEATAHIRSHADASISRVPVIALTAHTVDSNIDYAYRVGMNGYLLKPVAPEEFRKTLAGLFSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKZ8</accession>
    <name>D6SKZ8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase</fullName>
            <shortName evidence="1">ADH synthase</shortName>
            <shortName evidence="1">ADHS</shortName>
            <shortName evidence="1">ADTH synthase</shortName>
            <ecNumber evidence="1">2.2.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroA'</name>
        <name evidence="2" type="ORF">Dthio_PD2774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate</text>
            <dbReference type="Rhea" id="RHEA:25952"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="ChEBI" id="CHEBI:58860"/>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.2.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868491.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2774"/>
    <dbReference type="EnsemblBacteria" id="EFI35359">
        <property type="protein sequence ID" value="EFI35359"/>
        <property type="gene ID" value="Dthio_PD2774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1560751at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00960">
        <property type="entry name" value="ADH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010210">
        <property type="entry name" value="ADH_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01949">
        <property type="entry name" value="AroFGH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="DKFP binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="1">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="1">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="1">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="268" mass="28530" checksum="B8C52BEFED1D2F63" modified="2010-08-10" version="1">MHLGKSIRMERIFNRNTGRAIIVPVDHGVTVGPIDGIIDMRVTVDKVAEGGANAVLMHKGLARCGHRGKGHDVGLIVHLSASTSISPYPNAKTLVASVEDAIKLGADGISVHVNLGDESEREMLRDMGQVASKANEWGMPLLAMVYARGPKVKDEFDMNMVRHCARVGEELGADVVKVAYTGEADSFAKVVEACCIPVVIAGGPKLDNDRDLVKMVHDSVAAGAAGLSVGRNVFQHSDVTSLVKTLHHVVHDDMDVDEAMDVLSNGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL00</accession>
    <name>D6SL00_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868493.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2776"/>
    <dbReference type="EnsemblBacteria" id="EFI35361">
        <property type="protein sequence ID" value="EFI35361"/>
        <property type="gene ID" value="Dthio_PD2776"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="113"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="430" mass="48447" checksum="D7124A577ECD5782" modified="2010-08-10" version="1">MDKHDSIDLFVLGLDDFNRSKLETIDQDLAVNIYPLLDMDAVTSSEDYDVHAVLNTAENQLRAHPRPIGGIIGYWDFPVSLMVPILARRLGLTAPSVQGVVGCEHKYWSRLLQKKVAPAHVPSFQSVDPFDDQDLNEIMVNYPFWIKPVKSHSSHLGFKVRNHKDLARAVRKIRSGIAGMGNAFNEFLEYAHLPEEIARIGGNHCVVEGLIRGRQCTLEGFVHKGEIQVYGVVDSFRYPNGSSFSRYQYPSTLPGRVIQKMTQIAGKVLAETGLDHSAFNMEFFWDSKRDHIWILEINPRISQSHGDIFEKVDGTPHHRILVELALNRRPAWSPGKGPFACAAKVFMRRFQDALVTRSPHAQEIRAVEEQFPGTMISILASQGQRLSGMDPAEQDSYSFACAIIFTGAKNPGRLRQNIKKIKNALPFEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLC0</accession>
    <name>D6SLC0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868613.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35481">
        <property type="protein sequence ID" value="EFI35481"/>
        <property type="gene ID" value="Dthio_PD2903"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="11777" checksum="A0F99F627A644865" modified="2010-08-10" version="1">MPGIARFVRDNQPTVYHIISRTALQGLPIKDKRGQGSVSRGIDQKVVEKAGKKGYKISRVERFRYRCRYFTRLNRPKVYGSAVFNRVNPVKHPALTLIFSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLC2</accession>
    <name>D6SLC2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868615.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35483">
        <property type="protein sequence ID" value="EFI35483"/>
        <property type="gene ID" value="Dthio_PD2906"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="39781" checksum="31EA9AAEEA447960" modified="2010-08-10" version="1">MSKKIPNAHDLCFKSFFSREEFVRDFIQYYLPEEVKKHLDLTIIEIDMEGYLSEEFKEFYSDVVAKVYFKDRIHELELYFLFEHKSKPYRFTILQTLNYQVQKWMRLLVDGKLDQYLPIIVPVVIYNGYKGWNFSVQFEDLFQLPSEHFKDFIPQFRHILHDIGQMDEASFKTTTIMEIFHLLLKYIYYPELDTKIHEIYDLLEKFPDNDKLTDYLFIIVRYVMASGAIPEKRLLEHTKRFAGGEEMIGVAAREIEERVERTRRPYWEKQAELKNAHETLIDIATEAYGPLPGSLNEKIKSIQSLENLRALNRKVLRTQSLEEFTELVNRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLD0</accession>
    <name>D6SLD0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, NifA subfamily, Fis Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868623.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2914"/>
    <dbReference type="EnsemblBacteria" id="EFI35491">
        <property type="protein sequence ID" value="EFI35491"/>
        <property type="gene ID" value="Dthio_PD2914"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="197"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="517" mass="58931" checksum="04C547AB187E6D7D" modified="2010-08-10" version="1">MESLTQVKLNVLHEISKVIEKALDLDKALEAILKILADSLSMKRGAFSFIEEDSGLLVISASHGLTSQEKNRGVYRMDEGVTGRIFSTGKPFIVPDIAKEPLFLDKTGSRSMEKERISFAGVPVTLQGTTVGVLTVDRLFDQDISLEEDIQLLSIVAAMVAQFVSLNRQVKDREENLRRENQNLKTRLSSSFQRFFIVGKSSSMLQVRQMMEKVAPTRATVLLLGESGTGKTLIAGIIHELSERGKFPFIKVNCASLPENLLESELFGYEKGAFTGAERSKPGRFEEAHRGTIFLDEIGEMPAGLQAKLLRFLQEREFERLGGVKTHRVDVRVIAATNKELDKEVQEGRFREDLYYRLNVFPIWVPSLRERREDIPSLINHFLDKMAREYGRRLVLSNSSLDYLVEYEWPGNIREMENLMEKLSIMSEGQIVALKDLPSDMQQEKVCPGKVQEQARDHSLLDMEKKEILSALQRNSWIQSRAARELGLTQRQMGYRIKKFNLEEYVSRKKNIEKPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLE8</accession>
    <name>D6SLE8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868641.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2933"/>
    <dbReference type="EnsemblBacteria" id="EFI35509">
        <property type="protein sequence ID" value="EFI35509"/>
        <property type="gene ID" value="Dthio_PD2933"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1580190at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="208" mass="22562" checksum="B52F046070CD28BA" modified="2010-08-10" version="1">MQNEMVETFTAKAKAVSAEVRHIKSMQEAFDYTVNICVDKEACQFLMAGCELPVSDEAQQLCEIKPGEKVIAAPALDDKNLSGLTSQAEKQGITTITSELRRYLGGIDIGLAVADLGLAETGTLVLKSASEDLRLATMICEINVMVLPLSRMRQGSYDAEKELSEMLRDGANYLSFITGASRTADIERVLALGVHGPLELHILLLEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLL6</accession>
    <name>D6SLL6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3003"/>
    <dbReference type="EnsemblBacteria" id="EFI35577">
        <property type="protein sequence ID" value="EFI35577"/>
        <property type="gene ID" value="Dthio_PD3003"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="354" mass="41750" checksum="611BB51EDFCB8970" modified="2010-08-10" version="1">MKVLANQIHKEYSTSMSTTNIHDSTIKYFLSDRLNAISLLKSMLPEEIVKQLNFNKIYYEKDSYLPKSLQGYYSDLVVSVPTKCGLYVAKVFFLLEHKSTFKKNTPLQFLRYILEFWEQYQKNTGETRLPVIIPILIAHPEEGWKPTKVSDLVDLPSDDFTIFIPDFNFLLYDAVNDDPEDYDFDETLKALFTLWRYSGSPEFMQGVQKAFQLIKKVDPKARLLDFVQMILHYLEVTRDEKEYIDIKKIAETEIDEGEEYMGTIAEMFRREGREETEQRFLQEKPIWEKQVKVENSQEMLVKSLKMRFDLVKPNIKEQIRSIQDVDTLNDLFEMSFKCSSIEAFTDLLEKVTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLL7</accession>
    <name>D6SLL7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3004"/>
    <dbReference type="EnsemblBacteria" id="EFI35578">
        <property type="protein sequence ID" value="EFI35578"/>
        <property type="gene ID" value="Dthio_PD3004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="12161" checksum="BFFDF9981E32F3BD" modified="2010-08-10" version="1">MSRRPAILTNQILVPHNLQQEYPHKPMPEDTLFHMTWYLKELNHLWLLGNIDFGLLVLSRKPVQIKQDIYAAVKGCVPEDTPLENYLQQESYWVSHYPESAICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLN3</accession>
    <name>D6SLN3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxylamine reductase</fullName>
            <ecNumber evidence="6">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hybrid-cluster protein</fullName>
            <shortName evidence="6">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hcp</name>
        <name evidence="7" type="ORF">Dthio_PD3022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="6">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868723.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3022"/>
    <dbReference type="EnsemblBacteria" id="EFI35594">
        <property type="protein sequence ID" value="EFI35594"/>
        <property type="gene ID" value="Dthio_PD3022"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337713at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="6">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="565" mass="61481" checksum="CFE88DE6AC073E10" modified="2010-08-10" version="1">MFCYQCEQTAKGEGCTKIGVCGKQPDTAELQDLLVFALKGLSQVAMAGREKNVVDTKVGRFISEAMFSTLTNVNFDPERIAGLVKDTVELRDELKSKVSQAGGNVPASEAASFVPENTVEGMVSQGEKHGVVADKDPNEDIHSLKQTVTYGIKGICAYADHAAILGQEDDAVYEYVQRALASTLREDLSLEQWIELAMECGRTNIRAMELLDAGNTGTYGHPEPTKVPLGPKKGKAILVSGHDLKDLEMLLKQTEGKGINIYTHGEMLPCHGYPELKKYSHFHGHYGTAWQNQRKEFSQFPGPILMTTNCIQKPQESYKDRIFTTGLVGWPGVAHVNGDQESASLLERLKTVVGMASKGESEKDFSPVIDKALSMDGFAADEDKGHVMVGFGRNAVMSVAGTVIDAVKDGNIRHFFLVGGCDGAKPDRNYYTEFVEKVPGDCVVLTLACGKFRFFDKDLGEIGGIPRLLDVGQCNDAYSAVKIAMALAEAFECGVNDLPLSLVLSWYEQKAVAILLSLLALGVKDIRLGPSLPAFVSPNVLNYLVENYDIKPIKTPDEDLKAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLN9</accession>
    <name>D6SLN9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3028"/>
    <dbReference type="EnsemblBacteria" id="EFI35600">
        <property type="protein sequence ID" value="EFI35600"/>
        <property type="gene ID" value="Dthio_PD3028"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="207" mass="24337" checksum="197CCFF7EB2C8BC3" modified="2010-08-10" version="1">MSDEYDSPWKVALERYFPEFMEFYFPGIFADIDWSSGYDFLDKELQQVTKDAELGRRYVDKLVRVHRLSGDEGWVCVHIEVQGEAEDVFARRMFTYHYRLFDQYDKPLASLAVLADTSPGWHPDSFGYELYGCRLRFDFPAVKLLDWESEIDQLLESDNAFALVTAAHLLTKKTQGKPEERYAAKIRLIRILFARGWDRQRILDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLQ1</accession>
    <name>D6SLQ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868741.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3041"/>
    <dbReference type="EnsemblBacteria" id="EFI35612">
        <property type="protein sequence ID" value="EFI35612"/>
        <property type="gene ID" value="Dthio_PD3041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="378" mass="42490" checksum="8B6A29B6B9D3E3D3" modified="2010-08-10" version="1">MTNTNTIRTPLILIVDDSPLNRRMLRVVLNKAGYRIQEAEDGLQAREMAREHLPDLILLDVMMPHEDGFDTCIKLKKQSSTQDIPIIFISALNDTENIVKGLELGGVDYISKPFAQTEVMARIRVHLELKFAKERLVEAQVQRFADLKQAQESFLVEPDKLPGARFSYIYQPVLEAGGDFLDVVQTGENIHVYVVADVSGHDLGTAYMTSALKVLIDQNINPYTPMHESLKMINAVLNRILQPTQHLTANFLKVDRGRNKMSLYNAGHPAPVMVSGEGSEPRILEAEGDILGPFEQVEFTPLEKDIQPGDRVFLYTDGLVESFGENFMSREQGMDKLLQACREASDYQLQPALQHIFSVLRPEKSLLEDDAVLLATEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLQ8</accession>
    <name>D6SLQ8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="5 12">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ddl</name>
        <name evidence="16" type="ORF">Dthio_PD3048</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="5 12"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868748.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3048"/>
    <dbReference type="EnsemblBacteria" id="EFI35619">
        <property type="protein sequence ID" value="EFI35619"/>
        <property type="gene ID" value="Dthio_PD3048"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="100"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI35619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="33029" checksum="598B0033CD4F9AE6" modified="2010-08-10" version="1">MRVLLIAGGWSKERQVSLNGAAQIKEALKSLGHEVLFLDLSPDYQELVNKAREADAAIINLHGAPGEDGSIQGVLEDVGLPYQGSGVRGSFLALNKALSKQFYANHGLRTPKGGLYFPQGRLHHVPPPVICKPNQGGSSLDMQIFYNQEEMYSFLNQVDSEHEILVEELINGHEVSCAVLDNEPLPPILIQPVKGDFFDYNSKYDPDGAVEICPAPISQEASRSIQEMSLQAHRILGLRHYSRSDFMLDQQDNIYILETNTLPGMTRTSLVPKAAQQAGIGFTELIARLLSLALNSNQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLS9</accession>
    <name>D6SLS9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868769.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3069"/>
    <dbReference type="EnsemblBacteria" id="EFI35640">
        <property type="protein sequence ID" value="EFI35640"/>
        <property type="gene ID" value="Dthio_PD3069"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1945986at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="121" mass="14568" checksum="302AE63AADFA9B87" modified="2010-08-10" version="1">MSPRRIIVLMVLSLVISGTALWLTNLEIEFEDATWEEVHEEAEAGGYQILTTEELYKMHQEVEDLVIVDTRQEWEYRLGHVENAENFFMQPWFWDRWMKRGDLRDFLSQHARDKETALVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLU1</accession>
    <name>D6SLU1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868781.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3081"/>
    <dbReference type="EnsemblBacteria" id="EFI35652">
        <property type="protein sequence ID" value="EFI35652"/>
        <property type="gene ID" value="Dthio_PD3081"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017232">
        <property type="entry name" value="NtrY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037532">
        <property type="entry name" value="STHK_NtrY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="320"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="391"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="522"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="741" mass="84041" checksum="56B9D4F1FB657523" modified="2010-08-10" version="1">MNQNTIEVAGPDPREKRRRLREVYIALAAVGLMGLLTWIELHFFGVESYLFLAFFNVNLILLLLVLFLVVRNVFKLVIERRRKVLGSKLRTRLVMTFIALSIVPTVLMFFIAVRFVHTSVDYWFQEQVGQSMQQALEVGQVFYASVKQGLEVRSEIALDQIRSQQYLWGGPGMSNFLENKKEIEHDLSLMGIISPSLSEQNWFADEEWETYWPEIRQSVPWDELLESPEYWTGMWPSEESGDLVVGIMPVDEARTGFLVMGQTLEPGLLSRLDGIVQGIEEYRKLETIKNPMKTALYTILGVITLLIIFGSTWFGFKLSREISAPVQALAEGTERIARGDLSVRLQDQSDDELGLLVQSFNKMARDLEKSQNSLTRANMRLASQNQELESRGRYMHAVLDNITAGVISVDHEGRITTVNKAAEYILGIDSRKVLGQYPLDLVGGEYGSLIHEVLNQLHDLPESQWQRQLDLEVKGRIVKILVNAVILRGEQGDDYGIVAVFEDITELEKMQRLAAWREVARRIAHEIKNPLTPIKLSAQRLEKKFSSSVRDPSFEQSTQLIIRQVENLQQMVREFSTFAKLPEVRPRTDSLDSLVQEVVSMFEQSHRQIGWELTIASNIPQFSFDRDAMKRVLLNIFLNAAEAIDKTGDGKVSIDLDYDAQLNRVFVQVADNGPGLSSEERARLFEPYYSSKKEGTGLGLAIAKSIVSDHGGYVRVKSNQPRGTVFVVELPVRNPESVSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLY9</accession>
    <name>D6SLY9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868829.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3129"/>
    <dbReference type="EnsemblBacteria" id="EFI35700">
        <property type="protein sequence ID" value="EFI35700"/>
        <property type="gene ID" value="Dthio_PD3129"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50331TB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1959410at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10729" checksum="82280925D1516FFF" modified="2010-08-10" version="1">MQCDTIKKGVECTFMTARGCSYKEGQCYPIVEKCNGCDRIHEFGGQTYCKSYPEPAMKWEHNACNFATHVQATFDKSGQVKINPIKASKRAAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM31</accession>
    <name>D6SM31_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868871.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3171"/>
    <dbReference type="EnsemblBacteria" id="EFI35742">
        <property type="protein sequence ID" value="EFI35742"/>
        <property type="gene ID" value="Dthio_PD3171"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="301791at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018821">
        <property type="entry name" value="DUF294_put_nucleoTrafse_sb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005105">
        <property type="entry name" value="GlnD_Uridyltrans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03445">
        <property type="entry name" value="DUF294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10335">
        <property type="entry name" value="DUF294_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="245"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="645" mass="74123" checksum="2F4EDA560BD9218A" modified="2010-08-10" version="1">MFGQKKEGLQAHDPDMVVDFLQGVLPFKDLEHSTLVNLAKNANVDFYPKGTRVLTQDVSEVNYVYLIQKGGVKIYLQDQAGEISLKDYRGEGSVFGALAVIRGSRSSMTVEAVEDTFCFLFPKKSFLELLKTHPGFAQHYLKVFSRDYVQKSLDELRKERLTPKTEGSLYLFTVKVNDVIRRKPEIITPVQSVQQAAQRMSDLGIGSLLIRNEYGKVSGIITDKDIRSKVVAKGLPYSTEVEKVMSSPIKTISAQRVCFDALLDMMSNRIHHLAVQDEDRIIGVITSHDILVLQGESPVYLFKEIMHQNRIERLYELSLKVPLVVRPLIEEGAKANNITRMITILNDLILTRLLTLLQEQLGPPPVPFCWLLMGSEGRKEQTFRTDQDNALVYQDPENEEQKQKAEKYFETFGEEAINHLVKCGYPLCQGGNMASNPKWRQPLSVWKQYFSRWVNRPEPQEVLNSTIFFDFRPAYGDMVLGQELKDELQSLVKGKDMFLRYLAQDCFRTKPPLSFFKNFIVDRDGEHKNRLDLKARGLVPFWDFARVMALKHGIMETNTLERLEMLDREGHMPHNLFVRARESYEFQMQLRFVNQLKLMEAGEQPHNYIDPAELSDLEKQTLKGAFSVISNLQSFLKETFKLNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM40</accession>
    <name>D6SM40_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868880.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35751">
        <property type="protein sequence ID" value="EFI35751"/>
        <property type="gene ID" value="Dthio_PD3181"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RJ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1666410at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="254" mass="29083" checksum="04C9C6026AC72287" modified="2010-08-10" version="1">MDKDRIKELAENPDFIPGIYNYCDRWCERCAFTSRCMNFAVEKEFFQEQESSDEMNAAFWETISSTFEVTISMLYDLAQERGIDLDAVGEDQDAGHELAMQRAREHICTILAKKYREMAKEWLESSEVWTQDVAVKIPGVISAGEAPGLQESKEIISWYLFLIEAKIVRALHGKAEEEECELESYDRDADGSAKVALMGIDRSLAAWGVVHANIVRDRQGVQDILFCLDRLRRKMETVFPQARSFVRPGFDDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM47</accession>
    <name>D6SM47_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3188"/>
    <dbReference type="EnsemblBacteria" id="EFI35758">
        <property type="protein sequence ID" value="EFI35758"/>
        <property type="gene ID" value="Dthio_PD3188"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025639">
        <property type="entry name" value="DUF4338"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032806">
        <property type="entry name" value="YbfD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13808">
        <property type="entry name" value="DDE_Tnp_1_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14236">
        <property type="entry name" value="DUF4338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4338" evidence="4">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1_assoc" evidence="3">
        <location>
            <begin position="220"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="370"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="598" mass="68789" checksum="9642FE63CBBC8610" modified="2010-08-10" version="1">MHTKPRPSYLLSVRLQPIKREQESLFKSLMAKYHYLGASPKISETLWYVATYSDQWVALLTFSAAALKCAARDRWIGWEYRHRFDRLKLLANNTRFLILPGWNLPNLGSRILSLCAKRISFDWQQHFGHPLLLLETFVDPRRYTGTVYRASNWTELGLTKGFKRVGQGYSAKPSSPKLIFVLPLQANARKLLSCAILNAAYQKGEPKMTMNAKQMESLPDYFKTVTDPRRTHGRRHRISTVLSIAAAATLCGMKGYKAIYGWANKLGQKARQRFRCRKENGKYVIPSQFVIRDVLVRADPVELDLAMQRFNEDQGLEDTCLAFDGKTMKNAIDENARQTHIASVVGHESKTTHTQKKVGALPAEDDDQETKQTNEIGMFIPILEQIEISGKTITADALLTQKKLAEYIVGRNAAYLFTVKKNQPTLYFDIKKYFEHRKEPDYCLQDPPGHGRIDTRSIWTTTELNEYLEFPHVGQAFCIHKKSYDPKTNKVCENTFYGVTSHHPNKADPARILQIHRGHWSIENSKHYILDWTYDEDRNRIRTGNGPANTNRLRGFAIGLLKSKGVKDIAQKVRDLHQQIRPVLDYFKMTKNSQKHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM71</accession>
    <name>D6SM71_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ORF">Dthio_PD3217</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868911.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3217"/>
    <dbReference type="EnsemblBacteria" id="EFI35782">
        <property type="protein sequence ID" value="EFI35782"/>
        <property type="gene ID" value="Dthio_PD3217"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="3"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="333"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="236"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="463" mass="52601" checksum="092BE66E17133066" modified="2010-08-10" version="1">MSKVVARFAPSPTGYLHIGGARTALFNWLLARGSGGRFLLRIEDTDVERSSQEMTQAILDSMHWLGLDYDQEPYYQSKRFEVYKEYIQKLVRTGHAYYCRCTPEEVEEMREKARALGQKPKYSGKCREACLQPGPDTVIRLKAPQAGQTVYQDQVKGSIAVDNTQLDDLVLERMDGTPTYNLAVVADDIEMGITHVLRGDDHINNTPRQLLIYQALDVTPPFFGHVPMILGPDKKKLSKRHGALSVMAYKEMGYLPEALVNYLARLGWSYKDEEIFSLEDLLQKFSLDNLGASACVFDTEKLKWLNSHYIKESSPARLALILQQHLDASQPVPAQAYLENIIPLLQPRASTMQEMAEMAHFFLVPDQELEMDQKAVDKFLTPEAREYLREIAEILAGMEEFDQENLEQAMKVYIEEKNIKFKAIAQPLRVALTGKTASPGIFETMQVLGRESCVNRLRRVQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMC3</accession>
    <name>D6SMC3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868963.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3270"/>
    <dbReference type="EnsemblBacteria" id="EFI35834">
        <property type="protein sequence ID" value="EFI35834"/>
        <property type="gene ID" value="Dthio_PD3270"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018771">
        <property type="entry name" value="PocR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10114">
        <property type="entry name" value="PocR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="491"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="734"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="834"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="837"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="940" mass="106345" checksum="1400F8B855023B3E" modified="2010-08-10" version="1">MPDSNDLLQGSGFLVQDDLQDCLEILRDAPVGIFTSTPGGRFLSVNPAMARMLGYDSSHDLIDSITDISAQVYIDPLDRMEFIRLLEEQVEVFNHECRIRRRDGTVLWVAQNARLVRNDKGKITHIQGFITDVSAKKQAEAELREKTERLNSIAENMLDMVSITDLEGRFKYVGPSHAVLGYDLDYLPGRNVMEFVHPDDYKEVETSFGEFLACREDGRSVEYRYRRADGEYVWLETFGKFILDQDGAAREILFSTRDVTERRQAEQALRESETRVRTKLEAILEPYEDLGGLELGDILDTRTVQDFMDDFYYLTNIGGAIVDLKGRLLASTGWQEICVNFHRAHPDALANCRESDLMLSSGLTPGQFKLYKCKNNMWDMATPIVVGGHHLGNLYIGQFVFDDEELDIETFRDQAGKYGFDQEAYIRALHKVRRLDRDTVNRAMQFYSRFAMLISSLSWSNLELARSVHEQKVATQQADVANKAKSEFLANMSHEIRTPINGIMGILQLLQSTELSPEQQEYTNMGIVSASRLTRLLSDILDLSRIEAGQMEIRKEQVDLKKLCDSVDELFMVTSREKDISLEFTQDPCLPQVLLGDEARLQQIVFNLVGNALKFTQEGRISVNWHLQQRRGRDARVLLTVSDTGIGMTDDTLDELFKPFAQAENAFTRRYQGAGLGLSIVKRLVELMHGTLAVDSTPGQGSTFFVSLPLGMPEEPASRTRQSVESLQHGQKLKILLAEDDPSNQFPMKLLLEKSGHQVSLAENGEQVLTMLADQEFDCILMDIHMPVMDGVEATRRIRSMEHGARGMEHGAGGPSETLVYDREPFGLFHGAGMEQRAGDRNQKSEIKNQRSEDRGQETEDGDRTSEMGERIPEFLNSSIPQSPNLEVPESKTSRIPIIALTAYAMDGDRERFLHAGMDDYLAKPVQKEDLERVLNKHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMD1</accession>
    <name>D6SMD1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amphi-Trp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868971.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35842">
        <property type="protein sequence ID" value="EFI35842"/>
        <property type="gene ID" value="Dthio_PD3279"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZJWA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2059951at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20068">
        <property type="entry name" value="Amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amphi-Trp" evidence="2">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13548" checksum="8310633B11093CF6" modified="2010-08-10" version="1">MGKDELKFKAVVEKQSLIATLENLMDSIQVGRLYVGDGQQGILLVPAPHLKLEIRAESKKDKEKICMEISWRTDSKEFAFKEPELVISSQAPEITYESEAGDADQEYQESNEQTEEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMG5</accession>
    <name>D6SMG5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869005.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3315"/>
    <dbReference type="EnsemblBacteria" id="EFI35876">
        <property type="protein sequence ID" value="EFI35876"/>
        <property type="gene ID" value="Dthio_PD3315"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="499077at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="224" mass="25794" checksum="8B1A026E1690ED03" modified="2010-08-10" version="1">MNLQEKISLTRKIFEQALGLSPAGNIFAAWTGGKDSTVMLHQWMIFLQERGPGVQVRALNLDTGYKFPEVLEFRDEMAWEWGLELTVAGPDSSAMQDLQELSKVECCRRLKVSPLQEAVREHGVRVLLTGIRRDEHPSRENTPDVQEKNDLDYYQVNPIAHWTEMDIWSYIMLKGLPYCSLYDAGYRSLGCKPCTVKGTHMNERSGRDREKEENLDMLRSMGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMQ8</accession>
    <name>D6SMQ8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">Dthio_PD3411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869097.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3411"/>
    <dbReference type="EnsemblBacteria" id="EFI35969">
        <property type="protein sequence ID" value="EFI35969"/>
        <property type="gene ID" value="Dthio_PD3411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1480250at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="287"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="221"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="382" mass="42020" checksum="A687FD93C5CFBE56" modified="2010-08-10" version="1">MKNHREETGKILAGAGRVVIKIGSAVLTGREGLDLRVVSRLVDQICLLHDRGMDIILVSSGAVAAGCKVLSSCRSKSDLVFKQATSAVGQSRLMHAYDEIFGRYGKITAQILLTRNDLKSRERFINARNTMLQLLEWRAIPVINENDTVAVQELRFGDNDALGVMILNLVEADLFINLTSSDGVYRENPRENPDAQKIACIEDIHSEPLERMCQGKTQQGSGGMYSKLLSARKAAQLGVPTLILSGRDRFSLEKAFDGEDLGTWILPRDKSISSRKFWFAYNQEPAGEIVVDRGAAFAVFEKGKSLLPAGIVEIRGNFGKGALVKIVEQDSCRRPAVGLTNYKASDLRQIMGKKSGEIEGVLGQCLYPEAIHRDNMLLEAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMU8</accession>
    <name>D6SMU8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869137.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3451"/>
    <dbReference type="EnsemblBacteria" id="EFI36009">
        <property type="protein sequence ID" value="EFI36009"/>
        <property type="gene ID" value="Dthio_PD3451"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="141" mass="16354" checksum="93FD8C6468D08E0D" modified="2010-08-10" version="1">MLEQDHRILRVDRDADQESIRKSYIKLSRRYHPEHFPEKFRRIKCAYERLSLDPSTLADITRELARAESTDQITSLIIKQAGTEATEKKKKEELLMDPMTLEPVLNVRTVRQKISGLLQDIEKKGIKYKTAEETGRNEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMZ9</accession>
    <name>D6SMZ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869188.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3504"/>
    <dbReference type="EnsemblBacteria" id="EFI36060">
        <property type="protein sequence ID" value="EFI36060"/>
        <property type="gene ID" value="Dthio_PD3504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="26486" checksum="572A089F6FAF5568" modified="2010-08-10" version="1">MLSEKQKNKIYNRNFQTFHSGKKLRTKHKMFRDEILEYLKINKDKIIESTPLPSTDIGKDEEQSQFEIDLYNQMRKYIDDYVESTLQPEYEKEVREYLKAKERLLNGLDNLMEKIKNNEFSWYDGENVEWGGAGVIITSDCQRPARENDIFICVNYPNLIVGVFDQVKELGAGYIDFENKYVIYGFLAKSAQRQINKYENTLQEYNTIIFNMVKEMKEFIEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN02</accession>
    <name>D6SN02_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869191.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3507"/>
    <dbReference type="EnsemblBacteria" id="EFI36063">
        <property type="protein sequence ID" value="EFI36063"/>
        <property type="gene ID" value="Dthio_PD3507"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2126988at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="138" mass="16147" checksum="9A9D6A150C4B97FF" modified="2010-08-10" version="1">MVDYIRGLYRLRKISFKIQECKDEYYLKSVLSSFLKAEGKEVRSLDTGQAVIPLPMVKRWIVSRLPQFSEAIHQQIMVIRAEHEAKLSRERVISKKHQDRPDKVEFDESVLARKGAFWEYNHALILTCPGKIPGMDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN67</accession>
    <name>D6SN67_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SapC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869523.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1542"/>
    <dbReference type="EnsemblBacteria" id="EFI34193">
        <property type="protein sequence ID" value="EFI34193"/>
        <property type="gene ID" value="Dthio_PD1542"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1512520at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010836">
        <property type="entry name" value="SapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07277">
        <property type="entry name" value="SapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="12319" checksum="8966607403A0F654" modified="2010-08-10" version="1">MYQNTQALDKSQDIKFTQVSNYHFAAKENFCPVFLQELPQVVREYFICFPNNQTDLPHALLGFQQNTNQYVSEDGSWQAEYIPAYIRRYPFILAKKEDSAQGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNA2</accession>
    <name>D6SNA2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-D-glucosyl-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Uridine diphosphoglucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869556.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1579"/>
    <dbReference type="EnsemblBacteria" id="EFI34228">
        <property type="protein sequence ID" value="EFI34228"/>
        <property type="gene ID" value="Dthio_PD1579"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1895501at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="28421" checksum="06BDD1378BC649E8" modified="2010-08-10" version="1">MFIVDTMIIPAAGFGTRMQEFTRGKSKELLDVGGKPAIQYALEEAAAAGIRVVGIVLRKGKEEIGDYIIHSKKLSWLRESLDLHFFHQQTMNGECGAILAAGEIVEHRPFIVHYPDNIILNSQGLVTNSLRKGYIELGSDLVSLVAAGKCENHPSSQPMSMEHAFDEVYLLEPRMETRHFSAGLRTAGVYVASPTFLDACSVLLQKKEDKEVRDRDVHCLLAEQGHQIYGLKVKTKILDVGSPKGYLEARKLLDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNC2</accession>
    <name>D6SNC2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869576.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1599"/>
    <dbReference type="EnsemblBacteria" id="EFI34248">
        <property type="protein sequence ID" value="EFI34248"/>
        <property type="gene ID" value="Dthio_PD1599"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="139" mass="15811" checksum="92F6739671CF191B" modified="2010-08-10" version="1">MKPAPADIADRVEPVLSQHRQVIAAYLFGSAASGRLRPGSDIDIAVLLDERAGKFDRKEELERLHPPLCRALRHDVHLVFLNQASCLLLGQVIDKGVLLYVSDQEQLSLFRMRSLTLYTEFAPYMRMFRESMKKKVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNF0</accession>
    <name>D6SNF0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB proton channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869604.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1627"/>
    <dbReference type="EnsemblBacteria" id="EFI34276">
        <property type="protein sequence ID" value="EFI34276"/>
        <property type="gene ID" value="Dthio_PD1627"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="897037at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="101"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="274" mass="30023" checksum="A38DCABA34C09C91" modified="2010-08-10" version="1">MINKTITAGLICFTLFVSAFFLAGEASIYFNATAFLVVTSGTLGAGLLSSGPGRVKKALGFASRAYTEEQGREKRLLDALMSLGHLHRRHGIISPESIREINPVAAHGLELIKDGYSETEIREIMGSDAQAHCRFRQELEKVFRNMAAYAPSFGVAGSVIGLVGLLMGIEETSLILKNVPVTLVSTLYGIVLANFLLLPVAEKMRQEKEKEIREREMVLCAMINMSRGADFLKMQRMLNAMASEPELRVEDSGAFRRINAAIKNQGVKARAEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNH4</accession>
    <name>D6SNH4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Single-stranded nucleic acid binding R3H domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869628.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1651"/>
    <dbReference type="EnsemblBacteria" id="EFI34300">
        <property type="protein sequence ID" value="EFI34300"/>
        <property type="gene ID" value="Dthio_PD1651"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1304273at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="7">
        <location>
            <begin position="202"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="32192" checksum="27BF6AFB261A7D78" modified="2010-08-10" version="1">MDNYIEFSGKNVDEAIQSACKYFHINRDQLEVEIVSGGSSGIFGLVGVKKATIKAKRRPRKQEQEQKEEASAAAQQEEPLISAQEESEEDSPVGPIFEDDPEGDMEEDMEDQESDALKPPPARFLQELIQRLTTPLAPEVDIKIREDTSPITVVVQDTHNSGILLGRDGQTLSALQYITNRIIAKKYPGTARIQLDTENFLEKQTEKLEKNAQQLAQRAIKAGKTMSTRPLSSYHRRIVHLALQGENKIRTKSKGDGPMKRVLIMPKSSGRRKNKSQQQQQEQQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNM1</accession>
    <name>D6SNM1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869675.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1698"/>
    <dbReference type="EnsemblBacteria" id="EFI34347">
        <property type="protein sequence ID" value="EFI34347"/>
        <property type="gene ID" value="Dthio_PD1698"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1842462at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="156" mass="16867" checksum="48B1F68AFF38041A" modified="2010-08-10" version="1">MLSVNIPGYVKIDLAHLLLDYNGTLALDGEILDGVLSRLQKLSTKIEIHVLTADTFGRAKDRLAGLECRFHLIQEGDQARAKADYLQKTGAMNSAAVGNGRNDRLMLEQACLGIALIQEEGAALAALSAADVLCRDINHALDLLLHPLRLKATLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNS3</accession>
    <name>D6SNS3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KilA-N, DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1754"/>
    <dbReference type="EnsemblBacteria" id="EFI34399">
        <property type="protein sequence ID" value="EFI34399"/>
        <property type="gene ID" value="Dthio_PD1754"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018873">
        <property type="entry name" value="KilA-N_DNA-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10543">
        <property type="entry name" value="ORF6N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORF6N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="124" mass="14521" checksum="974BA8DE0C816A52" modified="2010-08-10" version="1">MDEIIPVENITSLIYQIRGYKVMLDKDLAELYGVETKRLKEQVRRNMERFPEDFMFELSQDEHENLRSQFATSSWGGTRYVPMAFTEHGVLMLSSVLKSDKAIQVNIQIMRAFTRLRQLVLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNT0</accession>
    <name>D6SNT0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Addiction module antidote protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869729.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1764"/>
    <dbReference type="EnsemblBacteria" id="EFI34406">
        <property type="protein sequence ID" value="EFI34406"/>
        <property type="gene ID" value="Dthio_PD1764"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2002329at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014057">
        <property type="entry name" value="HI1420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40275">
        <property type="entry name" value="PTHR40275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02684">
        <property type="entry name" value="dnstrm_HI1420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="13246" checksum="993DFBDD23F85C2C" modified="2010-08-10" version="1">MKKTVTSRYDVAEHLRTPEEMAAYLEACMEEAEGDAAFIAKALGDIARARGMSQVARDAGVSRESLYKALSGERTPGFDTVLKVMAALGLKLHAEVVHIPNHAQAHKDNVEQKTEDAHDAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNV0</accession>
    <name>D6SNV0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC</name>
        <name evidence="3" type="ORF">Dthio_PD1784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869748.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1784"/>
    <dbReference type="EnsemblBacteria" id="EFI34426">
        <property type="protein sequence ID" value="EFI34426"/>
        <property type="gene ID" value="Dthio_PD1784"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="951261at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="2">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="350" mass="38296" checksum="8254D62CA825741D" modified="2010-08-10" version="1">MQKKNVAVVGVTGYTGMELIRILNVHPGFEIGAVTSRSEAGRALQELFPAMQGTRSGSIAVTFPDPELVARDCEIVFLAVPHGAAMDMAAAFLDQGSRVVDLSADFRLRDPGEYATWYGLEHGRQERLKEAVYGLPEIYREQIAAANLVANPGCYPSSVILALYPGLKKELFHAEGIIADSKSGTSGAGRVAKTGTLFCEVADSFRAYSLGSHRHTPEMEQELSLASGRDMRLSFSPHLVPMNRGILSTCYVDLRSSIQTEEIRKAYREFYKDSPWVRIMPEGVLPETRWVRGTMFCDLGFVHDQRTGRLIIVSCIDNLCRGASGQAVANANLMSGYDLDLGLDAAPLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP22</accession>
    <name>D6SP22_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Dthio_PD1857</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869820.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1857"/>
    <dbReference type="EnsemblBacteria" id="EFI34498">
        <property type="protein sequence ID" value="EFI34498"/>
        <property type="gene ID" value="Dthio_PD1857"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="20" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="18">
        <location>
            <begin position="118"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="384"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="454"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="513"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="647"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="848"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1093"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1246"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="19">
        <location>
            <begin position="1454"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1147"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1295"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="10">
        <location>
            <position position="1493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFI34498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1547" mass="172768" checksum="996F1CDD9F3985D7" modified="2010-08-10" version="1">MSPEKKSGSNQRKGSPVVLAISLFAMLLGLFVLIGVILANFESDRRKQQEIELVQQALDGMKASLSSRLSANIYKVSAVKALVAMNPDLTQDDFARAMEVQFRGENDLRNIGLARDMVIQFMYPIEGNEAAVGLDYRTLPDQIEAVELARRVNEIVLAGPLALVQGGEGLIARIPISRRDESTGREAFWGMASVVMNSDEIFAGAGIRDEQDGLRTAIRGRDALGDGGDVFFGDPQVFENAPLTKVMELPHGSWQIAAIPSGGWHSSAIILTPLIWLYVLGAGTILSFTALIVFLLRKRERIENERKNLTHSLEVILNQTSDFIYYKDINSRFIFCSQTLADITNHAHWREMIGKHDFEVFPHDTATIYNEEEKPVFNEGKPILNRVNPFYKETGETGYVQTNKWPVFDDKQKVSGIFGISRDITEHKKAVEDLENERNLFAAGPVFTMEWSPEMQGRWTVKFASSNVEQILGYSPEEMQHSNFWYTEIIHPDDVEGIVNELRHNIANYIDSFETSYRLRTKAGYYLWTYDFTLLVRDEEGALTGIRSYMYDQSARKQAEEALRIAEERLEKTAYDLTENIPVGTYTMVQPPEGGMARFAFMSSQFLELTGLTREKAASDPLKAFACVHPDDFDAWVALNAKAFAEKTPFFGETRVVAHGEVRWVTAESKPRTLADGTTVWEGVLADITDRKRAEEALSETLGRFNDLVVYMSVGVYVFWIRADGRQEFEYVSDGWCAMNHLRREDVLANSAVAFNMIHPEELENFILLNQEAAREKKRFHWEGRVVINGEVRFALVESNPVFFDNGDCRWFGIQQDITERVQDQERLRIATMQADAASRAKSEFLANMSHEIRTPMNGVIGMTGLLLETDLNETQRRYAETVRSSGQALLALLNDILDFSKIESGKLELEALNFDLRDTLDNFASMMAFKAEEKGLEFICSADPDVPDNLIGDPGRIRQILTNLVGNAVKFTERGEVVVRVSIQESGVRSQESQEFCMLHFSVRDTGIGIPADKVGDLFQSFSQVDASITRKFGGTGLGLAISKQLAEMMGGDVGVDSVEGQGTTFWFTIRLALAGTAEAEVPVPADLLDVRALIVDDNATNREILMTRLLGWGMRPDEAKDGPTALGRLYTALAEDDPYHLAIIDMQMPGMDGEFLGRTIRADQKLQDVRLVMMSSAGMQGDARRMKDIWFAAFLAKPLRHDELFDCLSLVMAGDEPQDLVTRHSAREEKSRSGKIDFSDRKARILLAEDNITNQQVALAMLKNFGLSADAVANGLEAIKALKTVPYDLVLMDVQMLEMDGLAATRRIRAAEIRGRELEVRDQRLKSESQNSSIPESLNPLIPQSLNSRIPEFRIPIIAMTAHAMRGDRERCMEAGMDDYLAKPVEPGRLSQVLEKWLPVRNDERGMMNDEGGGTQAETEFSSLLITEQSSLEPDSGPPVFDKADLLLRLEDEELAASIVQEFIQTTPEKLASLAEAIRVQDSKAVHEISHALKGSAATVGAKALAAVLQEIEVAGKSGQLAGLERLLPEAEQEFEKLSDILDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP28</accession>
    <name>D6SP28_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent enzyme, D-cysteine desulfhydrase family</fullName>
            <ecNumber evidence="7">3.5.99.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.7" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869826.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1863"/>
    <dbReference type="EnsemblBacteria" id="EFI34504">
        <property type="protein sequence ID" value="EFI34504"/>
        <property type="gene ID" value="Dthio_PD1863"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1714795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005966">
        <property type="entry name" value="D-Cys_desShydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01275">
        <property type="entry name" value="ACC_deam_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="13"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="335" mass="36379" checksum="C690E370A45175DD" modified="2010-08-10" version="1">MNFTRYPRRAYLEEATPIEFMENLSTFLGMEVNLFVKRDDLLPGAGGGNKTRKLEFCLADALEQGADTIITCGAVQSNHCRLTASWCCKENLDCHLILEERVKGTYHPENNGNNFLFHLLDVNSISVVPGGSDMMAEMRKKGDELKSHGKKPYIVPGGASNPIGALGYVACAEEIMNQLNAGHQDIDHIVVPSGSAGTHAGMVAGMIGTNANIPVSGINVSRPKDVQEGIVYNLAEETAQKLEMKMSIPREAVVCYDQYVGPGYSLPTDSMVEAVRLFAKHEAILLDPVYSGKAAAGLLDLVRSGHFPRGSNVLFLHTGGSPALYAYMPTFRKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP66</accession>
    <name>D6SP66_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869862.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1914"/>
    <dbReference type="EnsemblBacteria" id="EFI34542">
        <property type="protein sequence ID" value="EFI34542"/>
        <property type="gene ID" value="Dthio_PD1914"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="297"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="482" mass="56699" checksum="3176849257DA9BC1" modified="2010-08-10" version="1">MSYRLNYCISSKEIAAIICLLLVQGVLVFWYEYSYRMELRQWTEDTIRIGFKPSQRVDANLSPYGPGLDRELVELFCSRNGLTPVWVELQDFRQGMEKLINHDLQLLLPVPGMQTPDKKSLQRGPVYLEGRFLVLHNQWRYPLRSLEDLCATDVVVPGRSAFDKILQDVREVLQCELEPSKRPEPGKDFFDALAERRFRFGIKDEKNYTFWKGFYPEVRRTEELDETYSLNWLWSSHYMNLDRNLERFWEDIKNSGLLDELLERYLGFYPKEQDPYELRQFQHALQNEMPKYAQTIRDVSRRYSLDPLLLVAIIYQESRFDPGATSRTGVRGLMQITSHTAEFLGIEDHLDPHQSIAGGARYLQMLGERMDRIGIESWDKWFMALAAYNQGLGHVYDARTLAERQGYNPDSWNGLKKTYPLLSYKEYYETVPRGYTRGYEAVNFVESVRYYYSLLYGHALLSRFEAEHLGGFLDLVPSDWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP71</accession>
    <name>D6SP71_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869867.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1919"/>
    <dbReference type="EnsemblBacteria" id="EFI34547">
        <property type="protein sequence ID" value="EFI34547"/>
        <property type="gene ID" value="Dthio_PD1919"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2067023at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="289" mass="33682" checksum="D1A8A161F4C08FEA" modified="2010-08-10" version="1">MNAFRLIFLLLVFAAVMLGLSQNTETLGLKAPLELDLWFIELSLPQVAMYVFIFFCFLLGIIFGIITFFPANREAREKLKVLRKKLRLLQEDFKTAEMERARQIMKRQEKISPDEEAFKEEIVSSASSRAWGKAAMAGCVVLFFILVALYYYGHTEFEKVHEQTKANMEKTTGMIEDTQSSLDSLEHDFRDADKKLGELDREFREETAKLQDATENMQEKLQKHSGEISELKLIPVKTRDYLTVMHLEQYLQTLGYLKKEADTEEDRKRLQEAAEEVRKALEHYREKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP80</accession>
    <name>D6SP80_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1928"/>
    <dbReference type="EnsemblBacteria" id="EFI34556">
        <property type="protein sequence ID" value="EFI34556"/>
        <property type="gene ID" value="Dthio_PD1928"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="18"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="327" mass="36324" checksum="5F4567AB5BE9F055" modified="2010-08-10" version="1">METRQKLIQNLDRIRGKRLLVIGDIMLDHYQWGEVSRISPEAPVPVVYVEKETYSLGGAGNVARNIKSLGGEPVLISVAGDDDHCREIKKMLDREGIEHTIVSSRKRKTTVKTRVIGNSQQIVRVDQENCNDLEPGLMAEITSLIEKKGFGEYVLVSDYGKGMVNRKTLSALQDYKVVLDPKTKNFRVYKDLFLMTPNQKEAEEGSNTKINSNKDIISTGKKIMKTKNLENLLITVGPMGMVLFRSNKEILHFPTSARKVYDVTGAGDTVIATMGICLQAQYSLPDACMTANFAAGLVVGQVGTAAADRENLVQSIESMSQPEIYHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPA7</accession>
    <name>D6SPA7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869903.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1955"/>
    <dbReference type="EnsemblBacteria" id="EFI34583">
        <property type="protein sequence ID" value="EFI34583"/>
        <property type="gene ID" value="Dthio_PD1955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="228" mass="24782" checksum="B4D4E0703EFAE239" modified="2010-08-10" version="1">MNEPLYKLENLSKSFTSGPETITVLDRVDLCIEKKETVAVQGASGCGKSTLLHILGTLDDPTEGKVFFNGQDLSTLTPVQKAALRRTEMGFIFQFHHLLPEFNTLENVAMPAVINGINRKKAHEAALEALDQVGLKHKAGQSVTTLSGGESQRAAIARAILPRPGVLLADEPTGNLDEAKGREVGDLLLHLNRELGMTLVVVTHNLDLASRMNINYELKSGGMYVLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPS3</accession>
    <name>D6SPS3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870067.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2123"/>
    <dbReference type="EnsemblBacteria" id="EFI34749">
        <property type="protein sequence ID" value="EFI34749"/>
        <property type="gene ID" value="Dthio_PD2123"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="182"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="384" mass="44533" checksum="BF3E0A76BC01B904" modified="2010-08-10" version="1">MPQHNFIPRILSIDLPENRSAFLWGPRKTGKTTLLRQQFSEAYWIDLLDYELFMLLSREPFRLRRILEAQSSMTVVIDEVQKIPHLMDEIHWLMENRSYRFLLSGSSARKLKRGNVNLLGGRAWRFELYPLVSRELGGFDLEKALVSGFLPSHYLSPDYRMDLQAYVHDYLKEEIQAEALTRNLPAFSRFLQSAAATSGMLLNYSNAARDSGVSVKTIREYYQILEDTLIGRILPPWKKSSRRRLIETAKFYFFDVGLVSALLNRYSLSPKTREFGRAFEQFILQECWAYRHYSRKDFPVSYWRTASGSEVDIILGDADVAIEVKAGEHAASKLPKGLHLFGEECRPGKSIIVSRDRYPEKISSRITILPWEQFCAKLWNGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ60</accession>
    <name>D6SQ60_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD2277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870200.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2277"/>
    <dbReference type="EnsemblBacteria" id="EFI34886">
        <property type="protein sequence ID" value="EFI34886"/>
        <property type="gene ID" value="Dthio_PD2277"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="85"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="588" mass="67090" checksum="46B08E277FD2D030" modified="2010-08-10" version="1">MYHACKPSLPQLRVWAPRAQRVDLVTRLDRQLMLPQDNGWWQAEESPGHGEDYSFLVDGEGPFPDPRSPWQPGGIEGQSRRLDHRRFEWSDQGFQPVPLSSAVIYELHVGTFSPEGTFKGVMHRLDHLVELGVSHVELMPVAEFSGSRGWGYDGVNLYAPHHVYGHPEELKELVNACHSRGLGVILDVVYNHLGPRGNYLPRFGPYFTDRYRTPWGDAVNLDGAYSDDVRRFFIENALMWLRDYHFDGLRLDAVHALYDFSARHFLEELAWEVKELEAGLGRHLVLIAESDLNDPRVIRPFQAGGYGMHAQWNEDFHHALHAALTGESQGYYADFGDLAHLAKALEKGFVYDGIYSQFRRRRHGRPAPDICGHRYVGCLQNHDQVGNRARGERSSQLLTQGQLKMGAALVLTSPFIPMLFQGEEWGARTPFLYFTAHEDAGLAREVFHGRLAEFKGFGWDPGDIPDPQDPETFVRSRLDRQELSQDRHAEILNWYKQLIRLRREYPELTSGRPEQVRVEFHEEKRWLIMRRGPLCVACNFSPAQQTVPLGGQATNLHIVLASQADAALYGWDLFLPGHCVAVLCCRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ72</accession>
    <name>D6SQ72_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="7 8">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the rubredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870212.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2289"/>
    <dbReference type="EnsemblBacteria" id="EFI34898">
        <property type="protein sequence ID" value="EFI34898"/>
        <property type="gene ID" value="Dthio_PD2289"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047418at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="53" mass="5558" checksum="644CDF0BDC47B98C" modified="2010-08-10" version="1">MQKWVCTICGYVYDSAAGDPDNGVAAGTKFEDVPDSWVCPVCGAAKDDFAPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQD0</accession>
    <name>D6SQD0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870270.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2348"/>
    <dbReference type="EnsemblBacteria" id="EFI34956">
        <property type="protein sequence ID" value="EFI34956"/>
        <property type="gene ID" value="Dthio_PD2348"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="281" mass="30573" checksum="6A321B0F96639167" modified="2010-08-10" version="1">MSTEKNKVYEALGYLKKIFPDFRPDVLVVLGSGLGDLARDFKPFASLDYSDVPGFVDSTVEGHEGTLFLCRDQDLCLAVMSGRVHLYEGRSPGEVVRNLRVMGLWGSGTAVLTNAAGALNPLFSTGNIMLITDHINMTGENPLVGDNVQEWGPRFPDMSNIYCRELQSLAAGAALEAKIPLEKGVYMGIKGPSLETPAETKAFRKLGADSIGMSTTLEAIAARHLGMRVLGYSCLTNKNLPDCMAETSHEEILEQARKINNNLVTLLRETLPRLTGVVRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQI4</accession>
    <name>D6SQI4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870324.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2402"/>
    <dbReference type="EnsemblBacteria" id="EFI35010">
        <property type="protein sequence ID" value="EFI35010"/>
        <property type="gene ID" value="Dthio_PD2402"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2042003at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="68" mass="8227" checksum="F947603BD30844B2" modified="2010-08-10" version="1">MTTVEKIQDEILSLPDSEKSRLFRWFADYEAKVWDHEIERNFTQGGRGQEFLDRVKSDYKAGKWSRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQK4</accession>
    <name>D6SQK4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">Dthio_PD2424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870344.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2424"/>
    <dbReference type="EnsemblBacteria" id="EFI35030">
        <property type="protein sequence ID" value="EFI35030"/>
        <property type="gene ID" value="Dthio_PD2424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="28985" checksum="8B856E52B7A5CD3A" modified="2010-08-10" version="1">MIHAPAKKSLGQNFLQDMNIARKIVDALEPGHKDRVLEIGPGKGVLTALLADRAGLVLGVEKDYFLTFALDRCPGLQAVNMDALQLDWSRLDRWPGLKIIGNLPYNIAQTLLWDMAAGCRSFDRAVVMVQKEVAQRITAGPGGKEYGALSIWLQSFTTPRVLFNVSPGVFRPRPSVDSSVLELRPLPADKIFFVPRDLARVVKTMFQNRRKQLGRILKTYWNDRRKIALEQCGLDPRARPEQLSPEDFQGLSKCLFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQK5</accession>
    <name>D6SQK5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870345.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2425"/>
    <dbReference type="EnsemblBacteria" id="EFI35031">
        <property type="protein sequence ID" value="EFI35031"/>
        <property type="gene ID" value="Dthio_PD2425"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="9852" checksum="FCF633C3F06689CD" modified="2010-08-10" version="1">MTKADLVSKMAEKASLTKADSEKALNAFLDSVQDTLVKEGKLTLTGFGTFAVEERKSRNGRNPRTGEEIKIPACKVVKFRPGKILKDAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQM4</accession>
    <name>D6SQM4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HI0933 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870364.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2444"/>
    <dbReference type="EnsemblBacteria" id="EFI35050">
        <property type="protein sequence ID" value="EFI35050"/>
        <property type="gene ID" value="Dthio_PD2444"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1513550at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="424" mass="45480" checksum="1224918137BBF654" modified="2010-08-10" version="1">MAETGSYQEVIVVGGGPAGLMAAGQAASRGLRVVLLEKKHLPARKLGITGQGRCNLTNTAAMNDFLRSFGHGAKFMRFALGRFFNQDLVSFFDALGLETVEERGGRIFPRTQQASDVVRTLVGWVKESGVKIQSGRAVRQVVAEQGRVQGVVADRQGAKEEFVGTDNIIIATGGASFPATGSTGDGYALARALGHEIVPVYPGLVPLETAGDTAPMMQGLSLRNVQAGIYVQGKKQAQDFGEMLFTHFGVSGPIVLTLSREAVQALNRNQEVKLVIDLKPAVSHTALKSRISSRMHARGKRKISNILKEFLPIKMIPVFLEKSGIDPDKPGSELTSPEHKALRMWCKELCLDITGHRSFNEAIITSGGVKLSEVDPRTMQSRKVSGLYFAGEVLDIDADTGGYNLQAAFSTGWVAGNSVGAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQY2</accession>
    <name>D6SQY2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2556"/>
    <dbReference type="EnsemblBacteria" id="EFI35158">
        <property type="protein sequence ID" value="EFI35158"/>
        <property type="gene ID" value="Dthio_PD2556"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063235at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046257">
        <property type="entry name" value="DUF6290"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19807">
        <property type="entry name" value="DUF6290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="9195" checksum="454B42E464FDA749" modified="2010-08-10" version="1">MENTKMHTVRLPVGLSQRLKLLSKATKRTKSHFIREALERTLEDLEDAYLAETAYEEYLKSKEKAISLEDVERDIDLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQY8</accession>
    <name>D6SQY8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2562"/>
    <dbReference type="EnsemblBacteria" id="EFI35164">
        <property type="protein sequence ID" value="EFI35164"/>
        <property type="gene ID" value="Dthio_PD2562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="31" mass="3593" checksum="566BD714B3CC8DD1" modified="2010-08-10" version="1">MSLTELNKEDDFQKEVMEHPGYAAVLMHMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR55</accession>
    <name>D6SR55_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870529.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0494"/>
    <dbReference type="EnsemblBacteria" id="EFI33171">
        <property type="protein sequence ID" value="EFI33171"/>
        <property type="gene ID" value="Dthio_PD0494"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="196" mass="22213" checksum="81B8E5AC2069088D" modified="2010-08-10" version="1">MANTNHPKKGSSITVEPIRSQEDIKSIKKLLSGNPRDHLLFTMGINNGLRIGDLLQLKVMDVQGVKPGDTIRVKEQKTGKTNILVINKATHKALQTYLSQTMSDPGDFLFKSQKGNAPLTVSYANRMIKDWCRQINLRGNYGTHTLRKTFGYIQRVHYGVGYELLCKRFNHSSPAVTMRYLGIEDKEVNNILMHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR90</accession>
    <name>D6SR90_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SagB-type dehydrogenase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0532"/>
    <dbReference type="EnsemblBacteria" id="EFI33206">
        <property type="protein sequence ID" value="EFI33206"/>
        <property type="gene ID" value="Dthio_PD0532"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="239" mass="26081" checksum="ACAAB93B985882AC" modified="2010-08-10" version="1">MTWTFARLGKIFLMAAGLNLSLLAGFCLQGGESMFFKKAAAQETVELPEFTTQGETSLEQALSKRKSTRSYADKPLKMEEAAQLLWAAQGVNRPQRDFRTAPSAGALFPLEVFLVAGDVEGLDPGVYRYLPKEHRLKKEKDGNVQGDLHRSALGQSPVRDAPAVVVIAGVYERTTVRYGDRGKQYVHMEVGHAGQNIHLQAETLGLGTVVIGAFDDSGVQSALGLEDKEVPMYLMPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRA9</accession>
    <name>D6SRA9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870583.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0551"/>
    <dbReference type="EnsemblBacteria" id="EFI33225">
        <property type="protein sequence ID" value="EFI33225"/>
        <property type="gene ID" value="Dthio_PD0551"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50349RW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1852695at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="324" mass="36512" checksum="2769B88CE50BE081" modified="2010-08-10" version="1">MQIFISINDILPAAALFFNLACFTGVPVLSLLGYLSGIARKKVFMFKMARQIARLGLLFIISTSLACAGLLGASYYYGPEADMWLEHHVFWESGLYICFVALVFFGFFTLCWNWLARVKWLHLLVGSVGGTACMLFAGILLWAVWRELDPLSPVYPQADSMFWPVLVQVYLLSIAAGSAAGLLYLLYRRNLDDFGRDYYRFVLGYVSRCGIFFAVVSPLTCIWLYFAGREVFMPDHLIMPGALFVIFLVLAVLLLLRIARSAHPLRNKAAIIVCPGVFLLVVAVRLVSYLEVADMAAQGEVLSTFMRDWMQALESWASGRIRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRD7</accession>
    <name>D6SRD7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870611.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0579"/>
    <dbReference type="EnsemblBacteria" id="EFI33253">
        <property type="protein sequence ID" value="EFI33253"/>
        <property type="gene ID" value="Dthio_PD0579"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1551582at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="587" mass="66135" checksum="E269FCC07E3E7F01" modified="2010-08-10" version="1">MSRTFFLHLQKDFLQVHPVDVWWISIPVDQLLLMGIISIKHACIADVYDHQETGNDMKQRPMETIQELQALDKKLASLIARRSRLLGDLSRNRQDKNKSLADPELEKRLWQVWKKELQPSNPSLVRQAFTLLNSMGYFEAERPHGDKPFCLYPTRRPLDHEFPGPLDLELVRGLVSMAALTPRQCMLEGLNVNDEILELVKAANQCGAKLSWRSSTLLGQGMGDVDLDGQSLFLGQSSFNFYFFFCLGLGHPCRIKFSGSATLKTLNLRFLLNLAPALGARLSSIEPQSYSLPAKLEAGGNLPEEVEIPEDADPEFVRALMLAATTYSSPLRIKYPRAAEVQVTDCLKIFAACRIRAQEQGQRTITVQPGQPVLEDHADIPLDPLLSGFLLALARMGKGRVRLKGNWPRKCARAEKILDLMRRSGLDIELEENGIAARDGEPRHKPVFDLSSFPEITPLIFPLALTREDDAPVRLLLPRESIHLETVLDLLVLLGYQFSQDDEGLSIFSRQAHHDKSPAWTSPGPCWSLGYCLLSFRFPGICLCNPGNLAALWPGFWKIFTNLSPKKAQESDEHFQKSRKRIRIQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRI9</accession>
    <name>D6SRI9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0631"/>
    <dbReference type="EnsemblBacteria" id="EFI33305">
        <property type="protein sequence ID" value="EFI33305"/>
        <property type="gene ID" value="Dthio_PD0631"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="269"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="481" mass="55122" checksum="BE30012B170E5A62" modified="2010-08-10" version="1">MFRSLIRSDPVKPFPFVKFLSWSSLIIILASSLALSVFIANYAREAIINKNHEFALLLAENLNHQIYQRFTLPTVLGFGRIELRQEAQYERLDQVVRSTIHSFHVLDVSIYDHQGVVSYSTDQDLVGQDELADRLVASTFEHGRHSFKLKKNISSWQAMFRFSLEPDSIVLKTVYPLRAERTLGVKDEPIMGILEFHQDITSDYESVIHFQWLIIIGSFTFSLVLFFLLYMIILRTDKVLDQRIREKERLEKELHQNEKLASMGRMVASIAHEIRNPLGIIRSSSEILYNRAKKQGSADARLLEAIFDESKRLSQTVNDFLDYARPKQPKLDQVDLVRIWNELISFMGSELDKHDITLEKDFPENMHVMGDKDLLYRAFYNIFVNSLQATPRGGVIRVKITWDDAPLVVVTDTGPGFEPTMIDRYLEPFYTTKDTGTGLGLAIVAGILQNHEAGLYISNNPEGGASVQVRFSTQQNSQQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRJ1</accession>
    <name>D6SRJ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870665.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0634"/>
    <dbReference type="EnsemblBacteria" id="EFI33307">
        <property type="protein sequence ID" value="EFI33307"/>
        <property type="gene ID" value="Dthio_PD0634"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="138" mass="15009" checksum="B6B44382D70EB303" modified="2010-08-10" version="1">MKVLRTPNMERCIGCYSCSLACARNVYKSLSWKRAGIQIRSSGGISTGFEARVCLACDPAACAAACPTEALRQRPGGGVFFKQNRCINCAECSKACPVGAIYFDPVRETPVLCIHCGRCVSYCPHECLEMVDTAKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRM0</accession>
    <name>D6SRM0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="16" type="ORF">Dthio_PD0664</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870694.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0664"/>
    <dbReference type="EnsemblBacteria" id="EFI33336">
        <property type="protein sequence ID" value="EFI33336"/>
        <property type="gene ID" value="Dthio_PD0664"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="15">
        <location>
            <begin position="115"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="350" mass="39302" checksum="E77D1221D4CC07E7" modified="2010-08-10" version="1">MNAVQEINSSLKSLIQEFKHVLDQASSLQDLEEARVAFLGRKGRLARIMSRLPELDPADRPEAGRTANEVKTELGRILESRKAELEKQAASEGDKTFDPTLPGRTPDMGSVHPVTRVIQDISDIFTGLGFEIVTGPEVETDFYNFEALNLPPGHPARDMQDTLYISESLVLRTHTSPLQIRTMEKRRPPLAAIAPGKVYRRDSDLTHTPMFHQIEGFLVDTHVSMADLRGTLTAFAQQIFDSEVKVRFRPSFFPFTEPSAEVDISCVMCQGRGRNEDGTTCRVCKETGWVEVLGCGMIDPEVFLQVGYDPEMYTGFAFGLGVERVAMLKYGINDLRMFFENDIKFLNQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRS3</accession>
    <name>D6SRS3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RelB antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0720"/>
    <dbReference type="EnsemblBacteria" id="EFI33389">
        <property type="protein sequence ID" value="EFI33389"/>
        <property type="gene ID" value="Dthio_PD0720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8741" checksum="14C4EBBAB0C82834" modified="2010-08-10" version="1">MKIHNDEPVLVKIEVPAHRLHNAEQILDQLGLDPSQAINIFLAKVELCQGLPFDVSLGDSALLSPSQQADEWSEAFGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRS4</accession>
    <name>D6SRS4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33390">
        <property type="protein sequence ID" value="EFI33390"/>
        <property type="gene ID" value="Dthio_PD0721"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="126" mass="14628" checksum="796E119A9E94A2F6" modified="2010-08-10" version="1">MPRNARFTLPHRPTVYHVISRTALSGLPLGDIEKNRLLEIIKYFSSIYFVDVLGFCIMGNHWHLAVKIYPRDYATRETNRDRQNILDFHPHFGYLFFHRHQPSPHGGSPCQETPDLPCLTGPRSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS08</accession>
    <name>D6SS08_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870826.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0808"/>
    <dbReference type="EnsemblBacteria" id="EFI33474">
        <property type="protein sequence ID" value="EFI33474"/>
        <property type="gene ID" value="Dthio_PD0808"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="348" mass="39342" checksum="240ED7B44F80DD46" modified="2010-08-10" version="1">MSKCNKFWGNHFSQPEIEKARTTGRILSMELELSMACNLRCIYCYAESGAPLENELRFEEITAAVDQAVELGARRIIVLGGGEPLAHPQILPVLQHIYKRGAAIDLFTNGTLITAETAEIFAELGVSPVIKMNSMNPEVQDRLAGRPGAFQDISQGFKHLQQAGYPSSGLALGVQTVICRHNLDELPEMWAWIRENSMVPYFETITLQGRARKHPDLFLEPEEIRDLFQRLSLMDKERFGFEWEPHPPVAGLTCMRHLYTCTVTVHGDVIPCPGVNIKVGNIRRDSLARILHQSRVVQDLRNIRENIKGACRDCELHPYCYGCRGMAYQYTGDYLAADPLCWKNPERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS82</accession>
    <name>D6SS82_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870898.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0882"/>
    <dbReference type="EnsemblBacteria" id="EFI33548">
        <property type="protein sequence ID" value="EFI33548"/>
        <property type="gene ID" value="Dthio_PD0882"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1034540at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="719"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="781"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1181" mass="132491" checksum="ADCA576DA4ADE50E" modified="2010-08-10" version="1">MPNKQPHSSIEPEIIIDQVLSISSSQFEGWPESVKKLALELAYELFIIRYNPFINPQSVQKSVFSRLENERGGLAPKFYRIISQGLENYWHEYLEDQRFKEKVRKKISRHLSSENIATNPSTLLECSTDATDLRLDMPMMVLFPENTAQVQAVVRLANEMEFGLVPRGGATGLTGGAIPCSRRTVVLNTGRLKAIMDIDPETMVLTAQSGVVTLDAIKAADRKGLLFTVDPASKAASSLGGNISENAGGPFAFEYGTTLDNILSYKMVTPTGDIIQVRRVNHPRHKILSHETVTFEVLDEQGELIKTINLTGDDIRTPGLGKDVTNKFLGGLPGIQKEGVDGLITEASFTLYPQLAHYRVLCLEFYGHSMHNAMQVIKEIVALRDEIRKSGDKVKISALEEFGTKYVQAIEYQKKSSTYEGEPISVLILQLDSDDAGALEDAVQKVVDLVSPYDQVDVFVASDDKEAEEFWEDRHRLSAITKHTSGFKINEDVVIPLDVIPEFADFLENLNLYYLALAYRKALNRVLDLPGVSIDDEYILMELQVASNILKQQMTKEALPEQIFELQIVFFFQDLKSRYPEHRDMLEDILQDLLRSRVIIANHMHAGDGNCHVNLPVNSNDPEMMRLAEAAAGKVFDEVLRLNGQVSGEHGIGLTKIKYLSRDKIEALKVYKEEVDPRNIFNPQKLVQRKLISVPYTFSFNQLIEDLRRAGLDESDLLINLLKSIQNCSHCGKCKQACPMFIPQKGKLYHPRNKNISLAGLIEALYYSMLVHGDPDPDVLRELRTIVEHCTACGRCTKICPVKIKGGKVSLEARNYLKDRKVSGHAIKDRLLDYASSDPSRQIPRMAKAAAVGQRFQNALVGMMPAFWRKRAKSPVFQSRAPAMEYRNLSEILDLSRQNLFVSEKSDSSRALLYFPGCGAGIFYPSIGLAGMALLLETGVNIVLPRTHLCCGYPLLASGDEEGMRKMERQNVQLLNRLISDFQWQGLEFTHILTSCGTCREGIEGYRMRGNGSHLKHQDVMQYLLENLEMSSATEPAQVLYHHSCHVEWEDINPLKAGEIYAQKFREGLNLDVQMSPGCCGESGLGAMSSPRVFNPVRQQKVQNLGEQLSGVDSRVPLLVGCPSCKIGIGRCMEMLGEKRRVLHTAEYAAERLLGNTWRKDFLQRMKKAERDDNMLLVKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSC8</accession>
    <name>D6SSC8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpD</name>
        <name evidence="13" type="ORF">Dthio_PD0929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870944.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0929"/>
    <dbReference type="EnsemblBacteria" id="EFI33594">
        <property type="protein sequence ID" value="EFI33594"/>
        <property type="gene ID" value="Dthio_PD0929"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="150"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="158"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="469" mass="51172" checksum="34F617928F51B80D" modified="2010-08-10" version="1">MSEQNVGKVVQVIGPVVDLEFPEGKLPNIMNAIYITNPTISDEKDNLVVEVAQHMGNNVVRCISMDATDGLVRGMEGKDTGDPIRVPVGKPTLGRILNVVGRPVDEQGPVKADKYYPIHRPAPSFVEQSTSIEILETGVKVIDLMIPFPKGGKMGMFGGAGVGKTVVLMEMINNIAKNHGGISVFAGVGERTREGNDLYHEMIDAGVIDKAALIYGQMNEPPGARARVGLTALTAAEYYRDEENQDVLLFIDNIFRFTQAGTEVSALLGRMPSAVGYQPTLATDLGALQERITSTDKGSITSVQAIYVPADDLTDPSPATTFAHLDGTIVLSRPIAELGIYPAVDPLDSTSRVLDPNVISQEHYSVAREVQMILQKYKDLQDIIAILGMDELSDEDKITVSRARKMQRFLSQPFHVAEQFTGKAGRYVKIEDTIKGFREIIDGKHDDIPENAFYMVGTIDEALEKAKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSI8</accession>
    <name>D6SSI8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF559 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871003.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0990"/>
    <dbReference type="EnsemblBacteria" id="EFI33654">
        <property type="protein sequence ID" value="EFI33654"/>
        <property type="gene ID" value="Dthio_PD0990"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2013215at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="14605" checksum="CF993EDB114762C2" modified="2010-08-10" version="1">MKSEIYNQKKLKPHRKILRREMTPAESKLWTFLKSKQLEGRKFRRQHSVGPYIVDFYCPAESLVLELDGEVHNDQMRRDYDETRQEYMENLGLKVLRFENRQIFTDIDNVLESIKKHFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSJ6</accession>
    <name>D6SSJ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dissimilatory sulfite reductase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871011.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0998"/>
    <dbReference type="EnsemblBacteria" id="EFI33662">
        <property type="protein sequence ID" value="EFI33662"/>
        <property type="gene ID" value="Dthio_PD0998"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ER5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020553at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014793">
        <property type="entry name" value="DsrD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08679">
        <property type="entry name" value="DsrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DsrD" evidence="1">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8624" checksum="73E9EF5E0BA19D4C" modified="2010-08-10" version="1">MDKEAAKQEIINFLESKSGSKTKFYFNDFTKIFPDMKAREVKKLLSELVQEEKLVYWSSGSTTMYGMKGAGKTAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSJ9</accession>
    <name>D6SSJ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871014.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1001"/>
    <dbReference type="EnsemblBacteria" id="EFI33665">
        <property type="protein sequence ID" value="EFI33665"/>
        <property type="gene ID" value="Dthio_PD1001"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="205" mass="23005" checksum="099164FFA0185DB9" modified="2010-08-10" version="1">MTQSSIEEKIQELKARLAKNPECGVTNYNLGVHYMALRDFETARQYLQEAIRKSPDLAEAYVQLGGIAMNEGDLDGCFSYNEMASKIRHRFAVPHGNMGFVHLQRGDVDKAIASLKRAISFDPQFVQAHATLGNAYYMQGDLEGCLQQCQKAVDLEPNFGPAYNTMGLACMDRQDFEAASKYFKKAQETGYEVAPEIWQELEQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSU7</accession>
    <name>D6SSU7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate/ketoisovalerate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871112.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1102"/>
    <dbReference type="EnsemblBacteria" id="EFI33763">
        <property type="protein sequence ID" value="EFI33763"/>
        <property type="gene ID" value="Dthio_PD1102"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1603697at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="198" mass="20926" checksum="34DEA399C4612F02" modified="2010-08-10" version="1">MKPLRIFFSGVGGQGTLTATRLLAETALENGMEVTAGEIHGMAQRGGVVHSFVLVGGYMSPKISHAEADILLGFEPLETLRALPFLRPGGLALSSDTPIPPLSVSMGKEQYPDIDYIRENVAGCAGKSYFVPCTELAGQAGNVQTANTVLLGAFFAGGFFELDLDVFLKGIQKRLPPKLVDANLKAARLGAEFISSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSV0</accession>
    <name>D6SSV0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="9" type="ORF">Dthio_PD1105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871115.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1105"/>
    <dbReference type="EnsemblBacteria" id="EFI33766">
        <property type="protein sequence ID" value="EFI33766"/>
        <property type="gene ID" value="Dthio_PD1105"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="292"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="355" mass="37827" checksum="8E16AF25AAD9EE8E" modified="2010-08-10" version="1">MSKDSFGSLFRVTTYGESHGPGLGGIIQGCPPGIALSEDIIQRELDKRKPGQGAASTRRKEADLVQILSGVFEGRTTGTAIGFHIANQDQRSRDYSGIKDIYRPGHGDITYEAKYGIRDYRGGGRSSGRETVSRVAAGAVAQEFLRTLGIRVLAYTAELGGIQARVQDMAGAQKRPFFSPDPEVVSIWEELVQEVKSQGDSLGGIVEIRAENVPAGLGEPVFDKLDARLAYALMGVGAVKGVEIGAGFAASRMRGSENNDQMGPDGFLSNHAGGVLAGITSGQPLVVRAGVKPIPSIAITQKTMTRQGTQTRVNIGGRHDISAIPRIVPVLKSMVMLVLADMVLLQRAVKTTENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSY8</accession>
    <name>D6SSY8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cobQ</name>
        <name evidence="16" type="ORF">Dthio_PD1143</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:11492"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58563"/>
            <dbReference type="ChEBI" id="CHEBI:58675"/>
            <dbReference type="EC" id="4.1.1.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871153.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1143"/>
    <dbReference type="EnsemblBacteria" id="EFI33804">
        <property type="protein sequence ID" value="EFI33804"/>
        <property type="gene ID" value="Dthio_PD1143"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="744477at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005860">
        <property type="entry name" value="CobD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01140">
        <property type="entry name" value="L_thr_O3P_dcar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="13">
        <location>
            <begin position="43"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="CbiA" evidence="14">
        <location>
            <begin position="372"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="15">
        <location>
            <begin position="623"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="861" mass="93919" checksum="99F1855C312611CC" modified="2010-08-10" version="1">MSTSPQQPHGGDISALARKSGLSPDAIVDFSASINPLGFPEWLRPLISTTLEKAAHYPDPGACDLVQAACRRYNTRPQEVLAGNGTAEIISLLPLAMNFKRAVIPAPTYADYARACLAAGLKVHRVNLDQALDFALDPAELAPHLQGRDLVFICRPNNPTGLDVDAAGIRRLAADFPDSLFVVDEAFGDFVPDFDSLVQNRPVNVTVLLSMTKMFALPGLRLGLALADPEVVRAVSGIQPFWSVNVLAQAAGVQALQDHEFVLKTREYVARKRNSLSQSLGEIPGIKIYPGQANFLLLGLDERLPEASELTVLLLEKHGLAVRDCSNFHGLDHRHVRVAVRSSRENQMLVRAMHSVLTAKPPRPAQSKPPAIMFQGTSSNAGKSILAAAMCRILLQDGYRPAPFKSQNMSLNSFVTSQGGEMGRAQVVQAQAARLEPDVRMNPVLLKPSSQTGCQVIINGQAVGNMGATGYVDYKPKAFQAARQAYDSLGREFDVLVLEGAGSPAEINLKSHDIVNMAMAEYARSPVLIVGDIDRGGVFASFAGTMEVLAEWERKLIRGFVVNKFRGDASLLGNAFELTLQHTGRPVVGVVPYMQNLDLPDEDSVGWKEGIKDQNGHAEDCVRVGVADLPHISNFTDFDALRLEPDVSLETVRSPNDLQGLDAVIIPGSKNVFQDLAWLDQTGLKAAISRLGSEQKVEIIGICGGLQMLGNEISDPFELESPGQKVQAAALLDIYTEMAHQKTLTRVEATHIQSGLNVLGYEIHHGVSRLGGRPLLRLPDGKNEGVLSESGLVWGTYLHGIFDADEFRRWVIDQLRSRRGMEPKNQVMCIYNPDQALDRLAEQVRSSLDLELIYKWMGLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST12</accession>
    <name>D6ST12_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871177.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1167"/>
    <dbReference type="EnsemblBacteria" id="EFI33828">
        <property type="protein sequence ID" value="EFI33828"/>
        <property type="gene ID" value="Dthio_PD1167"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2049198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="134"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="216" mass="24378" checksum="63A4BBFD7E4FBA64" modified="2010-08-10" version="1">MAARNTKNKKKQESRLSLQLTPGRTLTLGGFALLAIVWAFILGVFVGRGYNPEDVMPDISRIMPQEEKKQEEARILRPEELEFHERLRSEPARDPSPQEQPAAPVTESPQEQPLETAALPPEPEPAPEPETEAEAESFVYTFQVGSFQSMERAGGLQQRLYQEGFSASINRTFSGEEPWYRVIIEVETTPSNIDSFKQKLGEQGIDQPLLRNKRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STC5</accession>
    <name>D6STC5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871290.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1280"/>
    <dbReference type="EnsemblBacteria" id="EFI33941">
        <property type="protein sequence ID" value="EFI33941"/>
        <property type="gene ID" value="Dthio_PD1280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="83" mass="9846" checksum="9DECB3A4BB8D6D47" modified="2010-08-10" version="1">MSSLSQKKFSIDSEQIQLLESYREWGFLDQSSMVREALNRLSNDLRKNKQKDKMAKKARELVSEYNTDKEFTVFTDLDSEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6STD2</accession>
    <name>D6STD2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1287"/>
    <dbReference type="EnsemblBacteria" id="EFI33948">
        <property type="protein sequence ID" value="EFI33948"/>
        <property type="gene ID" value="Dthio_PD1287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="59" mass="6538" checksum="D20FFC2EE44B3913" modified="2010-08-10" version="1">MRLQKVPVSPRPCAENEPLRKNIEIRKGVHTTTPGPSLAKEGSRCRVSVNIQRDAETGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STE8</accession>
    <name>D6STE8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871313.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33964">
        <property type="protein sequence ID" value="EFI33964"/>
        <property type="gene ID" value="Dthio_PD1303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="8816" checksum="C33AB5675FEC5EF3" modified="2010-08-10" version="1">MYFILWTLLLLVFCSWFLGYKYIQMHAEIRAREHKIIAKEARIKEMIKGLEEEKEKLEQEIQEVSSELGQLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6STI2</accession>
    <name>D6STI2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ORF">Dthio_PD1337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871347.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1337"/>
    <dbReference type="EnsemblBacteria" id="EFI33998">
        <property type="protein sequence ID" value="EFI33998"/>
        <property type="gene ID" value="Dthio_PD1337"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="282" mass="31634" checksum="78E41CB278393E69" modified="2010-08-10" version="1">MSKTPSSSALWVVATPLGNPGDLSPRAAEVLSGCDFVLAEDTRRAGLLFKNLDIKAGELLSFHEHNEEKRMHRVADRIQAGENCALISDAGTPLMADPGYRLVRHCRESGIRVVPIPGPCSFVAALTASGLPPYPFAFLGFLPRKPAELEKVFKNWQEMPATLVFFERKNRVQSTLDKAYRVLGNREFCLARELTKTFEEFIRGRLDRIELDQDSLRGEITVIIGPPDPADLTKDAENVKDLITRYLEQGLLPRDVVREVRKEAKGWSGKDIYALMQDIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6STW0</accession>
    <name>D6STW0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871475.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1468"/>
    <dbReference type="EnsemblBacteria" id="EFI34126">
        <property type="protein sequence ID" value="EFI34126"/>
        <property type="gene ID" value="Dthio_PD1468"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1806799at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="352" mass="40047" checksum="F9AE379ECB5DA15A" modified="2010-08-10" version="1">MDPSALIPVSDTIPTEWGWFYFFLLLTFIMHLLLMNSMLGMGIMALVKHIKSGDKHCPVCKDISLKLPYTIAFTINFGVAPFLFLQVLYSQFIYTSSVLMGMYWLPVIALLLIFYYSAYIYDFKYDSLSRLKLLFLAVTVIFGLIIAFLFTNNMTLMLNPEKWTGYFENRSGTMLNLGDPTLIPRYLHFVLASIAVGGLATAIIWRFKKDPRATEYIREGLSWFSYATLVQVAVGVWFLISLPTDIMLLFMGGSALHTAIFLVALAGAGFSLFFGFKEMLWPTTAALLGTVVFMVLVRDLVRQAYLAPYFHPRDLEVVPQYSPLYFFIVFLVLGLAVVFYMLKLAFEAKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6STW4</accession>
    <name>D6STW4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proposed homoserine kinase</fullName>
            <ecNumber evidence="7">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871479.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1472"/>
    <dbReference type="EnsemblBacteria" id="EFI34130">
        <property type="protein sequence ID" value="EFI34130"/>
        <property type="gene ID" value="Dthio_PD1472"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1293048at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023665">
        <property type="entry name" value="ApgAM_prokaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02535">
        <property type="entry name" value="hyp_Hser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="6">
        <location>
            <begin position="3"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="398" mass="43434" checksum="E2A2EE1F591FE72C" modified="2010-08-10" version="1">MTKVLLLVGDGMGDWPLDELGGKTPLEEADTPGMDFLAPISRVGLCQTIPENMPPGSDIANMTLLGYEPGRYHTGRGPIEAVAMGLETAEDDLVWRCNLVNVSDFSQSGTMLDYAAGHIGSREGAELMHGLQKELGSSEFSFHAGVQYRHILVQKKGLPGRAAGLDITPPHDLLDQSLAGDLEKYQGYPALWDLVRRAAEILQEGGNDTSARAIWPWGQGGPLRLPAFKHRYFLEGAVISAVDLVKGLGRAAGMRVVDVPGATGLLDTNYQGKLHAAKTFLETGDFVFVHLEAPDECGHMGSIRDKVEAISRFDQQIVWPLLEHLRGEDVIIITCCDHLTPIKIRTHARDPVPFLVYDSRQQASGPETFSEKEARSTGIFLEHGHDLLPFALNRKGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU02</accession>
    <name>D6SU02_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0408"/>
    <dbReference type="EnsemblBacteria" id="EFI33093">
        <property type="protein sequence ID" value="EFI33093"/>
        <property type="gene ID" value="Dthio_PD0408"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="41" mass="4735" checksum="B3784D4BC844EDA1" modified="2010-08-10" version="1">MGMDAFGRVLIVVYAWRGDRIRIISARKAVRQEVKIYEGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU35</accession>
    <name>D6SU35_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">Dthio_PD0442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871817.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0442"/>
    <dbReference type="EnsemblBacteria" id="EFI33126">
        <property type="protein sequence ID" value="EFI33126"/>
        <property type="gene ID" value="Dthio_PD0442"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15162" checksum="61C6568DF21D3F9B" modified="2010-08-10" version="1">MVFVDTTVWIDFFADLDQPHVVTLSELIEQEEDLSLCGIILAEVLQGIRSDKDFIKTREYLGGLVFLPMGQATFLRAAEVYRSLRKKGVTIRKPVDCMIASVAMEYDICLLHNDRDFDHIARHSGLRVFSTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU65</accession>
    <name>D6SU65_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871541.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0152"/>
    <dbReference type="EnsemblBacteria" id="EFI32845">
        <property type="protein sequence ID" value="EFI32845"/>
        <property type="gene ID" value="Dthio_PD0152"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1107373at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039480">
        <property type="entry name" value="C-C_Bond_Lyase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15617">
        <property type="entry name" value="C-C_Bond_Lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="380" mass="43552" checksum="B393A819BE4D76F4" modified="2010-08-10" version="1">MRHHQYNPGFQFVNEPVDFNKFTPKNLLQYCLGATLYMPGTKDVVEKIRERRLPDLTSMVMCFEDAIQETDVPLAEENVLKHLDILSSSLQNGEITHDDIPLIFLRVRNHKQFTKFGERLSPSQADVLSGFVFPKFYSSNGHEYFRYLESLNRNLNVSLYGMPILEGKSIALIETRIDELRKISNLLEPYRDIVLNLRVGGTDFSSIFGVRRGINYSIYDILTVRDCLSDILNFFNRKDEDYIISAPVWEYFLAYKKVNLEHLLEKDIHRSLLNRSPILNDAIDGLLREVILDKANGFVGKTIIHPSHLKYVNAMQAVTKEEYEDASQILGTTGGVIKSSTANKMNEINPHKNWAYKTVNRAKAFGVVENEASYVSLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU80</accession>
    <name>D6SU80_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0168"/>
    <dbReference type="EnsemblBacteria" id="EFI32860">
        <property type="protein sequence ID" value="EFI32860"/>
        <property type="gene ID" value="Dthio_PD0168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="214" mass="23841" checksum="E4EEFE46C11DD312" modified="2010-08-10" version="1">MKNLVFDVNVILDLWLERKSEAQLLQLAGILESGTGDGYNCWICSSSLHVLEYVTRRELKRDGADPHTAKLTSRQLMEQLFEYVSVLSCFGFQQDDNLLSRTDLEDAQIVRAASLLNSPTSIVTNEKRFDTSGTEVLELMPSEVPGWLREPASSSIVFVDLAAQQDGIRTSLERKKKGTVSSCVLFQLMLSILPTAQPPALKEVSHAPHSPFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUB6</accession>
    <name>D6SUB6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="10" type="ORF">Dthio_PD0210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871589.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0210"/>
    <dbReference type="EnsemblBacteria" id="EFI32896">
        <property type="protein sequence ID" value="EFI32896"/>
        <property type="gene ID" value="Dthio_PD0210"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI32896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="534" mass="59099" checksum="4D075329497FC5C4" modified="2010-08-10" version="1">MKANLRWKIPIILLVLLVSLAFFLPTFSKVKDSRIGEYLPDRQLNLGLDLQGGIHLLLNVEVEKAMERSLSQAGLDIRDDARENQIHVLRPSVNEDTKLEFTLLRSEQQGELEQLLSDRHPNLQIVDTEALEDDRIRYIMDYVPELKDEMHEMTMDQAVKTIRNRIDQFGLAEPDIRKQEENRVQVQLPGMDDPDRAIEIVGQTAHLEFKLVDEDADVRRAEEDGVVPPGSRLYYQVTEGPDDTESKQPIVLKDDTLMSGEHITNAHTAFDERNNPYVSLTFDSRGASIFERITGENIQERLAIVLDGEVYSTPVIQERISGGRASITGQFTVQEAHDLSVVLRAGALPAPVHIMEERTVGPSLGQESIERGVNSALIGGALVVAFIIFYYGFAGVVANTVLALNIILILAGLAGFGATLTLPGIAGIILTIGIAVDANVLIFERIREELRRGLSPRAAVQEGYNRATLTILDANVTTVIAAMILYQFGTGPVRGFAVTLTLGILASMFTAIFVSRVIFDIWIASRKPQTALNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUC3</accession>
    <name>D6SUC3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent protease ATPase subunit HslU</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Unfoldase HslU</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hslU</name>
        <name evidence="9" type="ORF">Dthio_PD0217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871596.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0217"/>
    <dbReference type="EnsemblBacteria" id="EFI32903">
        <property type="protein sequence ID" value="EFI32903"/>
        <property type="gene ID" value="Dthio_PD0217"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00249">
        <property type="entry name" value="HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="50"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="8">
        <location>
            <begin position="361"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="469" mass="53449" checksum="8D9EC91AE0CDE344" modified="2010-08-10" version="1">MSTTLTPREIVHELDRYIIGQQDAKNMVAIALRNRWRRQQLDPELREEIAPKNIIMIGPTGVGKTEVARRLAKLAGSPFFKVEASKFTEVGYVGRDVESMIRDLMEIGVNLVRSEEREKVQAKAEANAEERLLDLLLPPKKAPEGQQGGQGQQQVAFQLESTGQAGDGYSQDQQSQADENRTREKLRKLWRDGRLNDRTVEVEVQAGSNVEIMSMPGMEDMEMQFRDMFSRVFPKKKKTKKVKVKNAYEILLQEETERLVDMDKVTEIAKDRVEQSGIIFIDEIDKVCASDKSSKADVSREGVQRDLLPVVEGCVVNTKYGMVRSDHILFIAAGAFHYAKPSDLVPELQGRFPLRVELSALTGEDFYRILTEPQNALTRQYRALLETEGISLEFDNQALEELSSFAQKVNDETENIGARRLYTIMEKLLQDLSFKAPELAGQKITVDKEYVREQLKDVQEDRDLTRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUC7</accession>
    <name>D6SUC7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871600.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0221"/>
    <dbReference type="EnsemblBacteria" id="EFI32907">
        <property type="protein sequence ID" value="EFI32907"/>
        <property type="gene ID" value="Dthio_PD0221"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007413">
        <property type="entry name" value="DUF463_YcjX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38605">
        <property type="entry name" value="PTHR38605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04317">
        <property type="entry name" value="DUF463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="447" mass="51473" checksum="E2F386B79078A723" modified="2010-08-10" version="1">MKSLMRNVLNLRQHNRVVVTGIAGGGKTVFLTSLISHLMEFGQGQFHVGRGVDISDFRELSGREKWPPYFPHSTFREDLARGDWPEKTTDCSEFVCQFKRSDWMLHAQKMSFFDFPGERISDAAVAAFNDYGQWSDHILSHFSRHHDYARAAGPYLEYIRREQLDLDILLSLYRETLARLILDYKPLVTPSVFLLDQHGSTAEPGSVEEIASRRIAGLAENRQFAPLPEKARRDNPELARQLAVEYKIYRKQVALPVFDKISRAGSLVVLVDIPSLLAGGVGRYNDNRQILLDLFEVMRPSSDLGTMLLRYLKFWQKSLNRVAFVAAKADLVHPMDIENRRLIGLLKMMTERARRMLPHVESQWFVCSACHSTFPVEGVRRLKGKIARDNPDREFKEYSVPELPRSWPENWSPGDYPFFRVYPDAPENYLIPPRHTGLDQVFEFISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUE8</accession>
    <name>D6SUE8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32928">
        <property type="protein sequence ID" value="EFI32928"/>
        <property type="gene ID" value="Dthio_PD0242"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="213" mass="24035" checksum="035F12AC64BBA5F8" modified="2010-08-10" version="1">MDKKRGIIIITICIFLAAGLLVSGVYYGIQLESLHHEVSSFLKSISPFLFIVLMITLPAAGFPISVFLIMAGIKFGIFYATIVWILILPLHAMIGYFLSSRLRQTIKRLIEKRNYHVPKIPENSTAMYSFLFYAIPGIPYSGKNYILPLAGVPFSYCVLMNSIVQAPQGIPFIVLGRSATAMDPTLLYIALAMFMVIFVLLRWVKRKYWDVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUF5</accession>
    <name>D6SUF5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871628.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0249"/>
    <dbReference type="EnsemblBacteria" id="EFI32935">
        <property type="protein sequence ID" value="EFI32935"/>
        <property type="gene ID" value="Dthio_PD0249"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="350" mass="38298" checksum="647577E2F049B97B" modified="2010-08-10" version="1">MQEYKVAVIPGDGIGPEVVREGQKVLEAAGKKYGFRLDWHSYDLGGERYLKTGEILPDSVLEELKGFHAIYLGAIGHPDVKPGILEQGILLRTRFVLDLYVNLRPIKLYPGVECPLKEKGPEDIDYIVVRENTEGLYAGSGGFLRQGTEHEVAVQESVNTYMGVERCLRYAFELAATRKRRKLTLCGKTNVLTYAFGLWERVFREMAKEYPSVEIDYTHVDATCMWMIKSPEWFDVVVTDNMFGDIITDLGAITQGGLGIAAGGNINPRGVSMFEPIGGSAPKYAGQNKANPVAAILAGQLMLTDLGQAQAAQGLEEAVSRVLPRMQTQSAGRMGMSTSEVGDAIAAEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUJ3</accession>
    <name>D6SUJ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871666.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0287"/>
    <dbReference type="EnsemblBacteria" id="EFI32973">
        <property type="protein sequence ID" value="EFI32973"/>
        <property type="gene ID" value="Dthio_PD0287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="439"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="712" mass="78099" checksum="AA5D4DCE1BA0911E" modified="2010-08-10" version="1">MNNIAIGVKLVAGFVAVALIVVVVGLVGWRSANNLSGHIDEVGRVNMPAVNNLRIIEAEFETVVRSLRALVNPALGMEARQEQYQEIESARENYEKAWENYEALPRTEDETRLWASFEDAIQDWAEVNNQFLELSRELEEIGILNTEEFLGHLQQFRGDHYQVMEDVRGYVDFGIDFEGGDDPEACNFGVWLQDFDTDNQELLDILRRLQGPHDNFHGVVEPIRELADAGQEQQAREMLRDDMGRYADHVFMLFDELIDFAREANDLYTEMNRLIMVDSVEMQDRGQGLLQELIELNERQADRAVGLAERDAARGVTISLAGLAIGVILALGLGLFLTAVITRPLRKTVDFAEKVAQGSLDEELEVTGKNELGILAGSLRNMVSNLKTKIREAETKSAEAEEQAQKARQAMQEANQAKEQAEQAKSQGMLQAASSIEGVVERMTSASEELSAQVEQASRGADEQSSRAGEAATSMEEMNATVLEVAQNASKAAEGSDQARSKAQEGSDVVSRSVTAINRVQEQSSQLKSNMSQLGQQAEQIGKIMNVIEDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMNATKEVGQAITSIQQGTENNIQSMDQAAGLIDEATTLVNRSGDVLQEIVRLVQSAADQVQAIATATEEQSTASEEINKNIEEVSRISKETSEVMTQSAQAIGELSQQAQELQNLVNQLKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUM8</accession>
    <name>D6SUM8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="12" type="ORF">Dthio_PD0322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871701.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0322"/>
    <dbReference type="EnsemblBacteria" id="EFI33008">
        <property type="protein sequence ID" value="EFI33008"/>
        <property type="gene ID" value="Dthio_PD0322"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="110" mass="12448" checksum="B3EFF60BF0118D35" modified="2010-08-10" version="1">METRAIARYIRISPQKARLVGDNVRGLPVEDAVNILNFTPKKAARLLKKVLDSALANAEQNYSLDLDNLYVKQVRVDEGPTLKRIQPRAMGRANRILKRTSHITVIVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUV1</accession>
    <name>D6SUV1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0395"/>
    <dbReference type="EnsemblBacteria" id="EFI33081">
        <property type="protein sequence ID" value="EFI33081"/>
        <property type="gene ID" value="Dthio_PD0395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9441" checksum="6F0F0A84E3172319" modified="2010-08-10" version="1">MNAMGINRVPSAEACRQNFQELALNKDLQTILTALSIKLWKKSGAKNEYIEKDQMQWAGEWVHKQKPWMVCQTAFGKGQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV22</accession>
    <name>D6SV22_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871868.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0073"/>
    <dbReference type="EnsemblBacteria" id="EFI32778">
        <property type="protein sequence ID" value="EFI32778"/>
        <property type="gene ID" value="Dthio_PD0073"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="202"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="45811" checksum="F7E0246187B1B34C" modified="2010-08-10" version="1">MPKIHLTPSFVSNPPTVRNKAKVDYFDSDIPGFTLEVRSTGKCTYYQRYRDKFGRVKQARIGPTDSISLEDARHRAKQIRSQTIMGYDPREQVEKNRNMPSFKQFVEDKYIPYIKVHKRSWEFDEKLINQRIMPLWGNMKLSEITRDDVQELQSNFLRMGHKPGSVNRYMALVKYIFNLAERWEVIDKSPTRHVSRLEEENHKERYLSSDETERLLSELKKCRSPVVPDIIEFLILTGARRSEAVNLPWQELDMAKGVWIIPAERNKAKVKKVIPLSRGALNVLERRKENGCEYVFPNPETGEPMKHFHGTWDRIRKKAGIPDVRIHDLRHNFASLLINSGRSLYEVQKLLGHADISTTQRYAHLSQDTLKDATELVFSSIQGKTSESASGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJT2</accession>
    <name>D6SJT2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869260.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3588"/>
    <dbReference type="EnsemblBacteria" id="EFI36135">
        <property type="protein sequence ID" value="EFI36135"/>
        <property type="gene ID" value="Dthio_PD3588"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339TB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="27003" checksum="41FF7BCD964424AC" modified="2010-08-10" version="1">MKEEEKEDKWRKWLAMQNKDEIALWYKATDFEEKYFGDMNLDDFEEELSGKETWIGGKWVKVKRDFYTEFGITLGRWRFIIVKKPKGYAGKCFPKSCTIKIAEEYKDNDIVLLHEMIHAFECMLFKHEFFFQYVLIKLYKKLSEQVPNLDELLMFDQHVDSIVHSPLFCLKSIDLDLRLNQEIGTTYAYEREELFRPDNGEEGNFDTLDLDKMKVLMAKKYFGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJV2</accession>
    <name>D6SJV2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2979</name>
        <name evidence="9" type="ORF">Dthio_PD3534</name>
        <name evidence="10" type="ORF">Dthio_PD3611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase IS21/IS408/IS1162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868685.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2979"/>
    <dbReference type="EnsemblBacteria" id="EFI35553">
        <property type="protein sequence ID" value="EFI35553"/>
        <property type="gene ID" value="Dthio_PD2979"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36087">
        <property type="protein sequence ID" value="EFI36087"/>
        <property type="gene ID" value="Dthio_PD3534"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36155">
        <property type="protein sequence ID" value="EFI36155"/>
        <property type="gene ID" value="Dthio_PD3611"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="362657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="111"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI36155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="491" mass="56651" checksum="A8CDC1DC85B68F42" modified="2010-08-10" version="1">MIDYELYARIKHYHEQKGLTPAQIAKELQLDPRTVGKWLEAKQFHQRKSVTRPSKLDPFKDTIVRMLEEHPYTAVQVLRSIKEQGYTGGSSILKEYISKVRPKRSRAFLSLAFAPGECAQVDWGNHGSIQVGDSRRNLSFFVMVLCYSRMMYLEFTVSQSMEHFLSCHQNAFDAFGAVPKKIMVDNLKCAVLKHPYGQKPVLNPKYLDFAKHWGFEISACGVRKPHEKGRVENAIGYVKKNLLAGLELPDYRAINHYARHWCRATANVRIHAQTGKKPVDMLEEEREHLLPLPVNTYDIGVVTQVRASSQFRITLESNRYSVPARYAGKRLTLKTYPDRLCIYDGNNLVARHIRSFDKKRDIEDPDHVQELIAQRRAARDQQLFSRFLALSPRAKDYYFELEKKHLNIKHHVQKIVALSEIYGSEAVSRAMDDAFTYSAFSCEYVANILEQRARTMPAPGALHLTRREDLLDIEVKDPDLSIYDKPKEKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK12</accession>
    <name>D6SK12_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36215">
        <property type="protein sequence ID" value="EFI36215"/>
        <property type="gene ID" value="Dthio_PD3672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="246" mass="26822" checksum="EB154F8C918DC1B0" modified="2010-08-10" version="1">MFCDPGRKRGFFGINSEKGRDLIQPPPAPPWLRRGATPCPGFTAGKSALIYFSSGNSSFFFWLSLPRASSGQSVQGRDLIQPPPAPPWLRRGATPCPGFTAGKSALIYFSSGNSSFFFWLSLPRASSGQSVQGRDLIQPPPAPPWLRRGATPCPGFTAGKSALIYFSSGNSSFFFWLSLPRASSGQSVQGRDLIQPPPAPPWLRRGATPCHGFTSVDKCSNLVFIRKRFFSFWLSLPRASRGQCAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK20</accession>
    <name>D6SK20_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869345.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36223">
        <property type="protein sequence ID" value="EFI36223"/>
        <property type="gene ID" value="Dthio_PD3680"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031X79">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939090at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="221" mass="25136" checksum="D53313B94D473C71" modified="2010-08-10" version="1">MIWTVWEKVRGACLTRYVFGLILTVALLAGCASRYPLDIPEEQWEAMTPQEQLEARQEQAKLDRAAEERRAAEARAREAEAKKWLKDLEASREDARYGERLQCVLSPAQAYIGRSWREIEPLALDVVKGMVLKLDLKEADDGVFRYSTEAYAGFDGQTLSICPEEDYVQKNDPKCARVLATFEQYRKGVETTIKASDFLRGKIVCDLVPGEGMPKRLILEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK55</accession>
    <name>D6SK55_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869377.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3721"/>
    <dbReference type="EnsemblBacteria" id="EFI36258">
        <property type="protein sequence ID" value="EFI36258"/>
        <property type="gene ID" value="Dthio_PD3721"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="310" mass="35959" checksum="B4212387B151E0AC" modified="2010-08-10" version="1">MKYSDKRFCGNEQRIFRARYKITEPGVISHVTQRAAGKEPLFIDDTDYLTMLMLLKESVEKFDLRYYALSLMSNHIHILLEPRENNLPEAMRSIFSRYAAKFNTKYQRKGHLFGGPYRQSVCLDNTYLLTASLYIHLNPVRAGIVDKTDAYRWSSASLYCNESDVESFVDPGVVLRLVHDQEPEARKNYCRMLEQAHGHEPENALEHEGAIEKFCIRLSQIFPRLFKKLGKKTENTEKYLGCNASMLDLTRLDQAIENTDFSRSWSMESRKAKKYIVEQLLARGFKKTEIAGRLGISRMSVYNILNSHCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKD3</accession>
    <name>D6SKD3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3803</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869455.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3803"/>
    <dbReference type="EnsemblBacteria" id="EFI36336">
        <property type="protein sequence ID" value="EFI36336"/>
        <property type="gene ID" value="Dthio_PD3803"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="262"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="340"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="393"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="469"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="523"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="596"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="666"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="911"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1037" mass="116915" checksum="AA9754027BD4A77D" modified="2010-08-10" version="1">MSEDGTCKKSSVPSPIKCQELLIKAPMGVFTSTPEGRFLTANPAMAKMFGYDTPQEMIDSITDIASEFYAESSDRNKILQLLEVHQQVENFECRLIRRDGSWLWSSIDVLAMRDESGSITHYHGFITDITEHKQAQDQIEKKSEELELYFNSSLDLLCIANVDGRFLRLNPEWEKVLGYTTQELEGRMFLDFVHPDDVESTVAAVSRLENQEQVLNYVNRFCCKDGSYRWIEWRSRPLGRQIYAAARDITEHKKVLAKLQESEQSLARTLQAIGDGVISTDMDSRVVQMNPVAEKLCGWDEAEARGRLLSDVLRIVNADTRAVVDNPLQKVFATGHTLGLASHVMLLSRTGEEYHIADSAAPIRDSHGNITGAVLVFRDVTREHAQAERLRTSEERLDRAMAVKNEGIWDWNLVTNETYFDDRYYTMAGYSPNEFPQHFSGWAERVHPEDLQKATSAIEDCIAGKTETFDIEFRFKHKDGSWIWIQGQGKIMERNPDDSPLRMIGTHTDITERKLAEEALLESEEMQRKILQAVPDLIVRTDLEGIITFVNELAYPGLSYIPQASIYGRSLFSFIDARDLPRAQENALKRLEKNIGPQEYRLNFEEGISIDTEINGAVVYDKESMPVGMVYVIRDITDRKRDKKELLKAKEQAEAANQAKSRFLANMSHELRTPFNGIMGMMQLLQTTTLDEEQQEYVDMAIKSSQRFARLLSDILDLSSVETGRMSIFNSEFDLGEALGSIHDIFDASAREKGVFLEYLPGDDVPAKVIGDAVRVKQILITLVSNALKFTEKGVVEIRLDALCAAKGGDVRIKFAVSDTGIGIPEDQLKNLFTPFEQLDGSYTRKHQGAGLGLSIVKRLVELMNGNIDIDSLPGEGTTVHVVLPFGLSARDDRETPGKALSTEQSRDFLNILLAEDEPLNQKFMVTLLKKFGHNVVLAPNGKQAVEEFFRHDFDCVLMDIQMPEMTGLEATRAIREAKSAGSKRDVPIIAVTAHTQSGDRERFLDAGMDDYIGKPVSSQDFQRVFDKFFGVKQVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKF4</accession>
    <name>D6SKF4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869476.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3825"/>
    <dbReference type="EnsemblBacteria" id="EFI36357">
        <property type="protein sequence ID" value="EFI36357"/>
        <property type="gene ID" value="Dthio_PD3825"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1668121at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8448" checksum="2F407DE7049DCAAD" modified="2010-08-10" version="1">MNERITIDANICHGKPVIKGTRVLVANILSALGSGDSIEEILNDYPNITREDIFAAIKFGGQLSRFEELPYEEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKH6</accession>
    <name>D6SKH6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase NAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869495.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3851"/>
    <dbReference type="EnsemblBacteria" id="EFI36379">
        <property type="protein sequence ID" value="EFI36379"/>
        <property type="gene ID" value="Dthio_PD3851"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="168"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="30563" checksum="B1B1A9EF5A1C37A2" modified="2010-08-10" version="1">MRIGFIGLGLMGGPLARNLIRAGKNVLVYDLKEEAVDRTLEAGSTGERAASLSDLAGCELVFTSLPLPEHVKGTMLGDDGLYAKLSQGATHIELSTIDPGTANDLYAAAAAKGIGYIQCTLGKTPAHAEKAEEPMFIGGDKALVDKYQDIFKIIGIPNYVGSIEASCAVKLISNMIGMTNVAVLAEGIRVGEKAGLDRNQLLELLSDTGARSFQMDVRGPWIAADDFKPRFAVDLAMKDVRLGLEMARAWNLDLKAMEAALKYFQKCSESGFGQEDCNAVCKIVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKI3</accession>
    <name>D6SKI3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868328.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2601"/>
    <dbReference type="EnsemblBacteria" id="EFI35194">
        <property type="protein sequence ID" value="EFI35194"/>
        <property type="gene ID" value="Dthio_PD2601"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="195" mass="22721" checksum="D3353B87EDF2F2B4" modified="2010-08-10" version="1">MKTNHPIKGSSIRVEPIRRLEDIKAIKKLLRDSPRDLLLFTMGINNGLRIGDLLRLKVEDVQHLRPNEYLRIKEQKTGKHNVLLINKTVHKAMANYMEKLCPDSADYLFKSRKSGRAISVEHANRMVKNWCRQINLRGNYGTHTLRKTFGYIQRVHYGVGYELLCKRFNHSSSSVTMRYLGIEESEVNDILMNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKU1</accession>
    <name>D6SKU1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868434.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2717"/>
    <dbReference type="EnsemblBacteria" id="EFI35302">
        <property type="protein sequence ID" value="EFI35302"/>
        <property type="gene ID" value="Dthio_PD2717"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="39636" checksum="1FE60344B620A3E7" modified="2010-08-10" version="1">MNNNIYSNPLISIFTPVYNSEKYIEECIRSVLNQSYTNWNYTLIDNCSSDNSKKIINKYVMNDSRIKLYSNKKYLSQIANWNQGLKKIDRNSKYCKIVHADDWLYSDCIKKMVEIGEKYPNAGIISSYRLEENKVSLDGLAPDEEIVSGKKIAKLYLLNLLYVFGSPSSLLLRTEIIKKNDPFYDDNNIHADTDVCLKILKDWDLGFVHQVLTFTRRHNESNSSIIKKYDTRMIERVKTMKKYGKDFLSEYDYNKRMTRLTNSYHRFLAKKIFELKNISYWRYHYSEMKAADISINWYKVCLYFIFQLFRPIDTYPYIIKGSKDMHATQLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-04-22" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKX0</accession>
    <name>D6SKX0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868463.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35331">
        <property type="protein sequence ID" value="EFI35331"/>
        <property type="gene ID" value="Dthio_PD2746"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88664at68525"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13620" checksum="30B2FF4B43BD9707" modified="2010-08-10" version="1">MDKSQAYLENLDKIFSGDKALILKACQSFIKHSKTYMEIIHEAHRHKNGPELKRIAHSFKASFVMFGDADAQNAACDLEKIGADDKWDNCATKIKNFNDQLQNSIYHIQKILDSKFESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL18</accession>
    <name>D6SL18_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868511.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2795"/>
    <dbReference type="EnsemblBacteria" id="EFI35379">
        <property type="protein sequence ID" value="EFI35379"/>
        <property type="gene ID" value="Dthio_PD2795"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233189at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="214" mass="23117" checksum="DA1EAED2ABD4ED9A" modified="2010-08-10" version="1">MSFDPELFIHAMSHRAPPYILEHLNLVLIPMCIAVLIALPTSIMLTRPAYRRFTSRIMAVFNAGQTIPPLAVIAIFFPFLGLGYAPAILALSIYALLPIARNTITAISSVPQDVKEAARGMGMTPWEVLRKVELPLSVPGIMTGIKTSAVLTVSTAVLAALVGGKGMGAVIFAGINFFQAELILAGTVYIGIMAVLIERMLTLLEWYLSPSHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL37</accession>
    <name>D6SL37_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868530.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2814"/>
    <dbReference type="EnsemblBacteria" id="EFI35398">
        <property type="protein sequence ID" value="EFI35398"/>
        <property type="gene ID" value="Dthio_PD2814"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1560751at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="358" mass="38897" checksum="5AF41E1CF724ADB2" modified="2010-08-10" version="1">MAHNHSELTEMLGDEAEFLLNHQCRTIARDQLCLPGVDFVDKVYALSDRNNRVLVNLERLFSHGRLGGTGYMSILPVDQGVEHSGGASFAKNPAYFDPENIVKLAMEGGCNAVVSTFGVLGAVARKYAHKIPFVVKINHNELLTYPNTFDQIMFGTIDQASDMGAAAVGATIYFGADNSDRQIVEVARAFAYAHELGMATILWCYMRNSAFKTGGVDYHVAADLTGQANHLGVTLQADIIKQKLPEVNGGYKALNTGDSSYGKLDERIYSDLTTDHPIDLTRYQVANCYMGRAGLINSGGASGKNDYGEAVRTAVINKRAGGMGLISGRKAFQRPMDEGAKLLNLIQDVYLDDKITVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL81</accession>
    <name>D6SL81_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868574.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2862"/>
    <dbReference type="EnsemblBacteria" id="EFI35442">
        <property type="protein sequence ID" value="EFI35442"/>
        <property type="gene ID" value="Dthio_PD2862"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="798280at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="260" mass="30382" checksum="0415C1616DF0B34D" modified="2010-08-10" version="1">MISIEQLKNYYPASMAENAVFQKHILKEYVQLLTLDYLSSTEHIRKMTFIGGTNLRLTKGIDRFSEDLDFDCKNLIEEDFIRMSDDVLTFLQRSGFKVKARAREKSGLKAFRRSLYFPELLFNLGISGHREARFLLKLEAQDQQTPYEPAMEFIKGCGLFFPFPVPSQAVLCAMKIAAMLDRGKGRDYYDVMFLLSRTEPDYQFLGHRFAIHNLAELKAAVEKSLQAVDMRQKQKDFEHLLFNRDHSRRILHFAEFIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLA5</accession>
    <name>D6SLA5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyltransferase HypF</fullName>
            <ecNumber evidence="9">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD2886</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868598.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2886"/>
    <dbReference type="EnsemblBacteria" id="EFI35466">
        <property type="protein sequence ID" value="EFI35466"/>
        <property type="gene ID" value="Dthio_PD2886"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48295at2"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="11">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="12">
        <location>
            <begin position="201"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="768" mass="84563" checksum="4D75D2A2C4E4FC3C" modified="2010-08-10" version="1">MRRKRYIVNGRVQGVGFRPSVYRMAAQHGLTGSVQNTSLGVVIEVQGKEEALAWFEEELRGNPPPLAEITRIQTDETTPEAGESGFIILESSALEQSQVLISPDSAVCSDCTREILDPKDRRYLYPFTNCTNCGPRYTITGLIPYDRQNTSMACFEMCLQCRREYSDPGDRRFHAQPNACPQCGPGLWLTDADGNRISEHDSPLKKSAYLLKQGNILAIKGLGGFHLACDAADQEAVRELRRRKNRPHKPLAVMVPDIAAAVELAELSPLEAEILQSPSSPILAVKPIQPCPLSPELAPDTDLLGIMLAYTPLHLVLFEHFKALLTRQEIPALVMTSGNMNSEPISLGNREALGRLGQIADYFLLHDRDILVRCDDSVMCARGPGPAYLRRARGYTPQPVFLSRDGPSVLGTGPELKNTFCLTRNDQAFVSQHIGDLQNLENYGFYRECIAHLQHVLQVNPEMVISDLHPDYLSTRYARQESGLPVQALQHHYAHILSVMAENCFEGPCLGLALDGAGLGDDGTLWGGELLLVDNRDMTLQRVGSFEPVPLPGGDLAVREPWRIAAGFIHSLGMEHSVLARDFEQGLTKEEMLLRQMIEKNINSPLSSGCGRLFDAVAAMLGLVRSISYEGQGAVLLEKIQSHGQETAYELPVHHRNGLGILDTLTLFRQILKDHISGLSPAIISRRFHLSLVRGLCLWAAQAGNATGIRTIGLSGGVMHNLTLARELEAGLVRRSFNVLTHRFLPPGDACVSLGQAVYGRHLARLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLK1</accession>
    <name>D6SLK1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868694.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35562">
        <property type="protein sequence ID" value="EFI35562"/>
        <property type="gene ID" value="Dthio_PD2988"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2148889at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="307" mass="35675" checksum="E1C188A0B350D5A8" modified="2010-08-10" version="1">MTTKGLLSLREIANELKINYNTLISCKNYFEENLQVRNIGRTPKYQAEYADFFRLVFALKDEGYVMPQIVEIIQENQRDKFEPSLAEWVAKWHYELFNERMNEPVIERTDDLTNELMIEPTNELTNEPTNERTDDLMNERTNECTEPDWEVIVSEATSRMENKLSDHRTQLNSTITKLYQVTTELQQAAADLNRRISRLENELNGEAGSEPKLTELDLEELQIQQDNPPAPTRYEHASLEFVKASIQNGKPDRDAVIQWILSEKERDPQVSYGHLAKVLDEAQVPTLSGKTGWCRTTLRNIMVKHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLK2</accession>
    <name>D6SLK2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868695.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2989"/>
    <dbReference type="EnsemblBacteria" id="EFI35563">
        <property type="protein sequence ID" value="EFI35563"/>
        <property type="gene ID" value="Dthio_PD2989"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="202"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="390" mass="44882" checksum="458C9BAEFEBFD7EC" modified="2010-08-10" version="1">MPRQNLTPKFVTNPPKPTDKPKTDYFDTQVSGFLLEVRSSGKATYYLRYRDNTGQLKQVKLGTPETLSLDEARTRARATKSQTLIGFDPKAEQEKIKAIPTFKDFVYDSYLPYAKTYKKSWEQDQTMIEQRMLRVWGRRKLNSINTHDLIEFQNNLVKGGLKAGSVNRYMALVKYIFNLAERWEIIDKAPTRNARKLEDNGARERYLNQEEVYRLLEALNSCKSQVVPDLIEFLLLTGARKTEAAELTWQEVDMERGIWELPAQRNKAGKPKTVPLSEAAIKVLKRRADNGSRWVFPNPETGKPLRHFHNTWDRIRKQAGIPSARLHDLRHSFASFLVNSGRSLYEVQKLLGHSQLSTTQRYAHLTEDTLKEATEIAGSLVGIRKVENGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLN5</accession>
    <name>D6SLN5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3024"/>
    <dbReference type="EnsemblBacteria" id="EFI35596">
        <property type="protein sequence ID" value="EFI35596"/>
        <property type="gene ID" value="Dthio_PD3024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="46" mass="5024" checksum="3EAC68E10C360599" modified="2010-08-10" version="1">MTGIDTSFMVAFEIAEHPQCQEARNFAASNSDLGFALAPQVLSEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLP0</accession>
    <name>D6SLP0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868730.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3030"/>
    <dbReference type="EnsemblBacteria" id="EFI35601">
        <property type="protein sequence ID" value="EFI35601"/>
        <property type="gene ID" value="Dthio_PD3030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="373600at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="201" mass="23535" checksum="9B2E55BA1E6F1FEB" modified="2010-08-10" version="1">MEYYKFILAPFIGALIGWITNYLAVKMLFYPRRPVNILGWKLQGVFPKRQQELASNLGTLVERELISHEDIQNVINDPRFRERLRNILSEYIHNLLSRKLNSVHPVLGSILSSRVADSLQSRLHRESEKILPQLLQRVAEELEHTLDFKEVVRSKVESFSMDKLEEILYTIMRKEFRFIEIIGAVLGFVIGILQALFFFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLU7</accession>
    <name>D6SLU7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3087"/>
    <dbReference type="EnsemblBacteria" id="EFI35658">
        <property type="protein sequence ID" value="EFI35658"/>
        <property type="gene ID" value="Dthio_PD3087"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50344JF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677376at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="292" mass="33454" checksum="D54745F9E3D0E709" modified="2010-08-10" version="1">MFSLVFFLLGLSSAQAWQQVQVDVELDEDKSFQELQQQGLRSGYSQAVIRESQRIVPGELSEKRKEMLGEHLDWRIDDLILGYRIFSREEVDDRLLMDLEVNVDTAALRSILQRTGVYYTSTAPWKYDLSTRGSGPGDFGMLQRLQTITGVEVDSDAPTSVSLTRRQDGSWSGVIDYKDITHEVTGGNLYSVWSDLWAFFFTRPEVMSEMTMDFTLKTTGWATTDAIMHFDEMILSWDEKVEKGSILYIHTDVPSYRAGWTLTTLNPDLLKKRLGEYLPSRGVYHTIDENTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLV5</accession>
    <name>D6SLV5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868795.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3095"/>
    <dbReference type="EnsemblBacteria" id="EFI35666">
        <property type="protein sequence ID" value="EFI35666"/>
        <property type="gene ID" value="Dthio_PD3095"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="218" mass="25060" checksum="129FFA9F0134FF70" modified="2010-08-10" version="1">MIICNPLSSMSLKGLEGIIFDCDGVLFDSRDVNIHFYNRIREYFGLGPLSDNEEEFVHMHSVMDSLRYILPPECLDRLDEVRRQINYNELLPYMRMEEGVPDLLDLLRCKGLRIAINTNRTTTMNLLLQMHGLADFFWPVMTAGQVNRPKPHPESMYRILEMWSTSPGKVAFIGDSVVDQSAAGSAGVPFWAYKNQHLNADMLIPDFWTLREFIAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLV9</accession>
    <name>D6SLV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868799.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3099"/>
    <dbReference type="EnsemblBacteria" id="EFI35670">
        <property type="protein sequence ID" value="EFI35670"/>
        <property type="gene ID" value="Dthio_PD3099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038444">
        <property type="entry name" value="DUF465_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="9470" checksum="FAF4B5145B70B9A9" modified="2010-08-10" version="1">MEQYEKDLIVRYSEEDEELKKLLENHQMYEKQLERFENKHFLTPSEEREVREIKKKKLAGKTRMHAILDNYKAKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLY7</accession>
    <name>D6SLY7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">LL-diaminopimelate aminotransferase</fullName>
            <shortName evidence="6">DAP-AT</shortName>
            <shortName evidence="6">DAP-aminotransferase</shortName>
            <shortName evidence="6">LL-DAP-aminotransferase</shortName>
            <ecNumber evidence="4 6">2.6.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dapL</name>
        <name evidence="8" type="ORF">Dthio_PD3127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23988"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="EC" id="2.6.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.83" evidence="4 6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868827.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3127"/>
    <dbReference type="EnsemblBacteria" id="EFI35698">
        <property type="protein sequence ID" value="EFI35698"/>
        <property type="gene ID" value="Dthio_PD3127"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033362">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01642">
        <property type="entry name" value="DapL_aminotrans_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019942">
        <property type="entry name" value="DapL/ALD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43144">
        <property type="entry name" value="PTHR43144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03542">
        <property type="entry name" value="DAPAT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="7">
        <location>
            <begin position="35"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="407" mass="45450" checksum="76D2437B90F69EA7" modified="2010-08-10" version="1">MILINEHYNKLTASYLFADIAKRVQKFQDENPDKSIIKLGIGDVTLPLPAACVQAMHRALDEMAEPGSFRGYGPEQGYDFLREKIARHDFQERGAEIAPDEIFISDGAKCDTGNIQEIFSTDTRVAVPDPVYPVYVDTNVMAGRTGEMQDGRYQGLIYLECTPENSFIPDLPREQADLIYLCYPNNPTGAGISKQELQKWVDYARDNKALILFDAAYEAFIRDEAMPRSIFEIPGAREVAIEFRSFSKTAGFTGTRCAYTVVPRDCRAYDSQGRKTMVHPLWNRRHNTKFNGVAYPVQRAAEAVYSPEGQAQVKNNIDYYLSNAGIILKAMQDLGYKCTGGKNSPYIWIQSGSDSWSLFDALLNKAGVVCTPGTGFGPCGQGFIRISAFNTQENVQEAMHRISKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM97</accession>
    <name>D6SM97_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868937.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3243"/>
    <dbReference type="EnsemblBacteria" id="EFI35808">
        <property type="protein sequence ID" value="EFI35808"/>
        <property type="gene ID" value="Dthio_PD3243"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1663845at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024264">
        <property type="entry name" value="DUF3786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12654">
        <property type="entry name" value="DUF3786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3786" evidence="1">
        <location>
            <begin position="33"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="23196" checksum="1A63E8301896EAFE" modified="2010-08-10" version="1">MTDEYNTNDGEQEAWAILQGLDPQLVKKRTLAGSGAGSKSFSLMCLGRKLDIDPAERVISTHSRQAQVLLQDLGCYTRLSILRYLVHCPDEPLHNEWIKPASIPGGRIFDQGTHVLPLNEPAALIQKKTGSAQKACAGLGGHLHGNGDLSMILYPMPRFPVLFIFWYGDEEFAPVGSILIDALWRDHLPVDITWAAAKLSFEMLFNQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMK6</accession>
    <name>D6SMK6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869045.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3358"/>
    <dbReference type="EnsemblBacteria" id="EFI35917">
        <property type="protein sequence ID" value="EFI35917"/>
        <property type="gene ID" value="Dthio_PD3358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="146" mass="16221" checksum="47F2778802DC9B0F" modified="2010-08-10" version="1">MAEIKKILCAVDFSEMTPKVVEYADTLAKKMDADVHVIFVVQRLDHYASFNVAPPSLQEIHGEVLGEAEKKIDALVQEQFSTDKVTAKVLSGHADEEILRYAKDENVDLIVMGTHGRKGVDRLLFGSIAEKVVKTSQVPVMTIRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMN3</accession>
    <name>D6SMN3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869072.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3386"/>
    <dbReference type="EnsemblBacteria" id="EFI35944">
        <property type="protein sequence ID" value="EFI35944"/>
        <property type="gene ID" value="Dthio_PD3386"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="488"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="730"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="854" mass="96739" checksum="51E063985B2D2261" modified="2010-08-10" version="1">MKPAPTLTNILQRLLGWRLLLISMLIILGIAVLLGYFRYQEIRSEQRLQAASISSYVQSHIKSQMQTIRFLSRMVLYPEFEAIASHYKAHAGLFKRFLVLDESGRIRQVLPEMEAFQDYSRMIPATERLETSGEFYFSTPYMKPDEYTVTVSLSYTGHFSKILVAELDLDSLQEFITRITRMQKDDRVFVLDGYGNVLAHPESSVVAGQYNLGHLRPVARALQGQTGFLGMGRKYGELYLFSAEKVPEAEWTVFTAWSVKGQLLPVLMPIGFAGFLLFGFLGLLVWNVTWRVRQDVIDPLVSFTGEVEKLPRGAFDMGVQNYVSSFYELQALSSSFQDMAETVVRREETLRRSEQRLAGILDSLDAAVYVADMHSDEILFINSYIREKRGEVIGRKCWEVFQNAQQGPCSFCRKDELKNQSGTPEPARWEYQDQETGSSYDCRAMAIPWSDGRMVRIVISTDITERRDMEARLHQAHKMQAVGTLAGGIAHDFNNILQVISGHVRMLLEKKAQDDPDIKRIVQIQQAGERAAKLVRQLLTFSREIEGQFRPVDLNREAAETASLLKKSFPDQIALELRLDDGIKPVQGDPAQLEQVLLNLCNNALDAMPEGGRLTIETSMAHFQEPQLLEHFRVEPGSYVVLSISDTGEGIDEDIRQKIFDPFFTTKEPGKGTGLGLASVFGIVENHQGYIECRSSLGQGAKFRIYLPVAPEEEACFSDREEKKADSYEHILVVDDEPVLRELTREALEEAGYRASCAESGEQALEMYQKNQDSIALIIMDINMPGMGGYECIQRLLKLDLEVNILVVSGYSPEERLRQYLKSGRVGFMAKPYRVPELLSRVREAIDRPVQDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-04-22" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMZ2</accession>
    <name>D6SMZ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869181.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3496"/>
    <dbReference type="EnsemblBacteria" id="EFI36053">
        <property type="protein sequence ID" value="EFI36053"/>
        <property type="gene ID" value="Dthio_PD3496"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88435at68525"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="139" mass="16478" checksum="07646C9A7E95C778" modified="2010-08-10" version="1">MSEEAKATGKFWTLVWSNRQKGSYLLSNYETTHIKSLPNGWLLRHRFMGGKYFTRSSIIFVPDPAHTWEADHIEVQWERIYSRKTPNHVEYTNRLKTPQGWVIKEFFSTKRSASKEGTTCLSLTYFEDKDHQWVGVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMZ8</accession>
    <name>D6SMZ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-metabolising metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869187.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3503"/>
    <dbReference type="EnsemblBacteria" id="EFI36059">
        <property type="protein sequence ID" value="EFI36059"/>
        <property type="gene ID" value="Dthio_PD3503"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Lactamase_B" evidence="3">
        <location>
            <begin position="13"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="415" mass="46773" checksum="E60D1117BB2EDD08" modified="2010-08-10" version="1">MKVCIHRGSNQIGGSCVEIEQDGQRIILDIGLPLDSESNDKALLPLVKGLDGSDPSLLGVFLSHTHLDHTGLLKHISSEIKVGSGPAARRIMDAALPFLPDKFPPIPDGWEYDPWKSFQVGPFKITPYLVDHSAYDAYALLIEAGGKRLFYSGDFRGHGRKAKLFQNVLKSPPRNIDVLLMEGSTLGRIDQELRFPSETDIENELVEAFSNTQGLAMVHASGQNVDRVVSIMRASKRTNRILLIDLYTAVILEATQNKNIPQSHWPEMALLVPQAQRVQILNNSWFDKLKRHSSNRVFMEKVKQNPDKYTLLFRPLFTKDLNKGECLKGASYIYSQWEGYWERGDYDYVKDWLNIHGISKQSIHTSGHAAPSDLKALVQALNPGKVVPIHSYMPEKYTELFGNVEMHGDGEWWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN06</accession>
    <name>D6SN06_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869195.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3512"/>
    <dbReference type="EnsemblBacteria" id="EFI36067">
        <property type="protein sequence ID" value="EFI36067"/>
        <property type="gene ID" value="Dthio_PD3512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="61" mass="7011" checksum="9A207E51B355BFA5" modified="2010-08-10" version="1">MLTYGELLDILQSFDEKQLRQPAMIHIKDSEYVQQAQQVVVSDDDNAPVIIADICIQFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN45</accession>
    <name>D6SN45_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1519"/>
    <dbReference type="EnsemblBacteria" id="EFI34171">
        <property type="protein sequence ID" value="EFI34171"/>
        <property type="gene ID" value="Dthio_PD1519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="45" mass="5161" checksum="0278DD3786608893" modified="2010-08-10" version="1">MHVFTGGISKVTLSNGNLRIKLTHRGAVQRERRCRNPDYSDFSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SND0</accession>
    <name>D6SND0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869584.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34256">
        <property type="protein sequence ID" value="EFI34256"/>
        <property type="gene ID" value="Dthio_PD1607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="13748" checksum="E136CA7D7B45C233" modified="2010-08-10" version="1">MTYELNQELCLHNVAGCPLMLPDGTAIGTVEGVKKHKGGCEVWMVRTEEDRQIMFPIYEEIVVECSPDEHVVVDPPADLLQMYMEGKYPENPCRAICRFDLKARREAMATGHSSKNVQQHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SND6</accession>
    <name>D6SND6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869590.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1613"/>
    <dbReference type="EnsemblBacteria" id="EFI34262">
        <property type="protein sequence ID" value="EFI34262"/>
        <property type="gene ID" value="Dthio_PD1613"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1731282at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="2">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="138" mass="15108" checksum="FE176A872753DECF" modified="2010-08-10" version="1">MKLAVSIWNDLVAPVFDVSGRIMVVQAASGRIETREHHDLSGLDGLARIRRIAALDIEVLVCGAVSRLCHDLLLAWGIRVIACVSGRVDSILSALLSGQSDIQDFFMPGCPQSYQTHNTKFLAYLANALMRINPPRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SND7</accession>
    <name>D6SND7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869591.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1614"/>
    <dbReference type="EnsemblBacteria" id="EFI34263">
        <property type="protein sequence ID" value="EFI34263"/>
        <property type="gene ID" value="Dthio_PD1614"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="881796at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="364" mass="38756" checksum="7D11D4BDFBA69D66" modified="2010-08-10" version="1">MSKMWKPPWLELNIMLAFAVLTYIAILVSVTIVPTPEGGMGGGVIWGWLVGFFIVSSIIALVATVGGIGGGVLFTPFIMAFTPVDSLIARGTGLVVAMFSGLMATGPVAKSGLANVKMCIFLCVAFGIACFSGAVGAVLVAEHLGEWGEAFIRLLLGLLIGGLIIYFIFGGKKIEWPDVKKSDRITQALGLRQPFYEPSLKKVVDYGLTNMGWLFAGILLVGAGSGFFGMGAGWAIVPFQNVIAGTPVKVAAANSVVLLGMGDCIAVWPYFMMGALIPMFAAPWLAGQVVGGLLGALVLVQIKAGFVRWLLIGLMGFSCWGLITRALSMWDIIQRPPHWLNGLVLLLLLSFVMVNIIKESRLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SND8</accession>
    <name>D6SND8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869592.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1615"/>
    <dbReference type="EnsemblBacteria" id="EFI34264">
        <property type="protein sequence ID" value="EFI34264"/>
        <property type="gene ID" value="Dthio_PD1615"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZDE3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1989844at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="142" mass="16224" checksum="55C4BCB8F11DF0D5" modified="2010-08-10" version="1">MTEDRPLAPLHNRVYGSIVYWITFTSCLICFIGPMFAMFMPDNTAMNPYFTYALIFEGLSGEEIWVALYGEWPWFHSVWWKNFFTGDGFTMFGVALGTTVALWALIPTMVVFTREKQFQYVILSAIVCFMVILAASGIVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNE8</accession>
    <name>D6SNE8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869602.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1625"/>
    <dbReference type="EnsemblBacteria" id="EFI34274">
        <property type="protein sequence ID" value="EFI34274"/>
        <property type="gene ID" value="Dthio_PD1625"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="165" mass="18367" checksum="C1837C99CAB6D6AC" modified="2010-08-10" version="1">MQTLYLDYSKCIGCGTCESVCKFVHTYPRIIMTRTTDGWWVPLYCQHCENPKCMKACTKKAIYRDPDTGAILLNQELCAECPTKNCLMACPYVAMVCTGAQKTPITKCNLCLDRGGLGPACAPMCPCDALMLVDHKDLDKVKTPEAQKAYELVRQHIICPECPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNG0</accession>
    <name>D6SNG0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1637"/>
    <dbReference type="EnsemblBacteria" id="EFI34286">
        <property type="protein sequence ID" value="EFI34286"/>
        <property type="gene ID" value="Dthio_PD1637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="11846" checksum="3E74065320333120" modified="2010-08-10" version="1">MHSLSIVIFLPESVKMDRSRRTSRVQVFAFHINTAVPRPSLQASCSYLFRQRFGCGMGASTLLSWKGKQIQLHKSGCAGVKCILSVNLLKILLHGMFKQVKRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNL6</accession>
    <name>D6SNL6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SirA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869670.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1693"/>
    <dbReference type="EnsemblBacteria" id="EFI34342">
        <property type="protein sequence ID" value="EFI34342"/>
        <property type="gene ID" value="Dthio_PD1693"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="7957" checksum="9171A3A9EFEFF03E" modified="2010-08-10" version="1">MAHKVDARGLACPQPVLLTTEAIQNTGESEIEILVDNQASRENVGRAAESKGYQVAVSEEMDEDFRIVIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNS4</accession>
    <name>D6SNS4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-methylcytosine restriction system component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869723.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1755"/>
    <dbReference type="EnsemblBacteria" id="EFI34400">
        <property type="protein sequence ID" value="EFI34400"/>
        <property type="gene ID" value="Dthio_PD1755"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1826003at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019292">
        <property type="entry name" value="McrC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38733">
        <property type="entry name" value="PTHR38733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10117">
        <property type="entry name" value="McrBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="424" mass="49509" checksum="54B1B9184ED8781A" modified="2010-08-10" version="1">MNKLVQVFEHSQLPVGDKLKEVHFRRLVKYNERHGNVFFAVGHNRIYFRNYVGVIQVGSLTIEILPKADNSLNNDQTTRDKWQRALVEMIRRSGLIRLTSLTDAMLSTHSARLLDIFFRSFLSEVEQLAHHGLVRKYRKNQDNLTTLKGRLLFQKQITLNLVRRERFYTEHVHYERNNPFNQILGTALDILILTSSNPHLSAQARNLALSFEDIDRINAAEVTFSRLNYTRNTERYRRAIQLARLIILNYCPDVRSGGEDVLAILFDMNNLFERYVYAQLKRAEAMNSEQNVSFRAQVQQPFWRTERIRKHIRPDIIAEIGQGYDQKRVVIDTKWKIPRDGKPADTDLHQMYAYNVHFGAKQSLLLYPRTSSTCDIQGCFEQPVHFSDIGENSCGMCFVELFDQDDKLLGEKTGNMIIDRLRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP04</accession>
    <name>D6SP04_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Peptide methionine sulfoxide reductase MsrA</fullName>
                <shortName evidence="7">Protein-methionine-S-oxide reductase</shortName>
                <ecNumber evidence="7">1.8.4.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Peptide-methionine (S)-S-oxide reductase</fullName>
                <shortName evidence="7">Peptide Met(O) reductase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Peptide methionine sulfoxide reductase MsrB</fullName>
                <ecNumber evidence="6">1.8.4.12</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="6">Peptide-methionine (R)-S-oxide reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">msrA</name>
        <name evidence="6" type="synonym">msrB</name>
        <name evidence="10" type="ORF">Dthio_PD1839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="7"/>
    <dbReference type="EC" id="1.8.4.12" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869802.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1839"/>
    <dbReference type="EnsemblBacteria" id="EFI34480">
        <property type="protein sequence ID" value="EFI34480"/>
        <property type="gene ID" value="Dthio_PD1839"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="9">
        <location>
            <begin position="192"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="37605" checksum="2E809C2F2DD33B76" modified="2010-08-10" version="1">MNTVKETAQQATFAGGCFWCLEADLAKLEGVLEVVSGYTGGHTENPTYEQVTTGLTGHFEAVRVNFDPGLISYNQLLDVFWKSIDPIDPGGQFADRGSQYRTVIFYHNEEQRVAAAESRKALQATGKFRGPVATLILPADEFYPAEDYHQKYYEKNKEHYRRYRVLSGRQDFLERQWGHSTPDAGNNRTSVSEHPEVKLTPMQYRVTRQDGTEPPFDNEYWDHKEEGLYVDIISGEPLFSSKDKYDSGTGWPSFTRPIKEENIVQRPDHSLPSPRTEVRSAGSDSHLGHVFDDGPEPTGMRFCINSAALRFVPAEDLEQEGYAEFLDLFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP53</accession>
    <name>D6SP53_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD1898</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1898"/>
    <dbReference type="EnsemblBacteria" id="EFI34529">
        <property type="protein sequence ID" value="EFI34529"/>
        <property type="gene ID" value="Dthio_PD1898"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25184at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="288"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1016" mass="114279" checksum="107F172F0EFE5EA4" modified="2010-08-10" version="1">MPTDTSEKGLETLIVESLVNEAGYVQGSNDDYSREHVMDLAKLREFLEATQPETVETLALDQDCPKRTQFLHRLDAEIAKRGVIDVLRKGVKHGPVSLDLFYGTPTPGNTKAAQLHAANIFSATRQLRYSQDETQLALDLGIFINGLPVATFELKNSLTKQTVNDAVRQYKRDRSPNEPLFKFGRCMVHFAVDDNEVQMCTHLKGKDSWFLPFNQGWNDGAGNPPNPDGLKTDYLWKRILTKLGLTDILENYAEIVEEKDERGRKKHPKQIFPRYHQLDAVRKLLADAAVKGAGEKYLIQHSAGSGKSNSIAWLAHQLISLEDGLPAEASACAAGTAVRSAQAGGRSVFDSVVVITDRRVLDKQIRNTIRQFAQVSSVVGAVTGESGSKTQQLSGFLKAGKKIIISTVQTFPFILDAIGDEHRGKRFAIIIDEAHSSQGGKTSAKMHMALEDLGEYKTSWEELDAEDKINRIMESRKMLANASYFAFTATPKNKTLEIFGIPGKPVDGKVPYRPFHSYTMKQAIQEGFILDVLAHYTPVNTWSRLAKEVEDDPEFDTKKALKKLRRYVESHDHAIRTKAEIMVVHFHEQVVARRKIGGRARAMIICSSIKRAIQYYEAVSAYLRERKSPYHAIVAFSDFEQDGKKITEASLNGFPSSKIEEYFKAGEIKDISGKDPYRFLIVADKFQTGYDEPLLHTMYVDKVLSGIKAVQTLSRLNRAHPQKTDTFVLDFMNDADTIKAAFSDYYRTTVLSEETDPNKLHDLKAALDGYQVYSYEQVDQLVRLFLDGEDRDNLDPILDVCVGVYNDELDEDGQVDFKGKAKAFTRTYQFLASVLPYTNAEWEKLSIFLNFLIPKLPAPVEQDLSKGILEAIDMDSYRAEVKQMMQLALPDEDAEIGPVPTSGGGRKPEPELDALSNILKAFNDRFGNIEWEDADRIRKVITEDIPAKVKEDQAYQNAMKNSSKSAARLEHDRALEKVVIEMLSDHTELFKQFSDNPGFKKWLADTIFGVTYDETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP56</accession>
    <name>D6SP56_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I site-specific deoxyribonuclease, HsdR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1902"/>
    <dbReference type="EnsemblBacteria" id="EFI34532">
        <property type="protein sequence ID" value="EFI34532"/>
        <property type="gene ID" value="Dthio_PD1902"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="56" mass="6528" checksum="B706A0D8CB1AB4B6" modified="2010-08-10" version="1">MVSRARPERLTQNRVVDLFTRSEAEGGLGYRYLGDWHQSERQPALQPMPLSMLVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPI2</accession>
    <name>D6SPI2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="11" type="ORF">Dthio_PD2030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869978.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2030"/>
    <dbReference type="EnsemblBacteria" id="EFI34658">
        <property type="protein sequence ID" value="EFI34658"/>
        <property type="gene ID" value="Dthio_PD2030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="165" mass="18324" checksum="A20542EC00A50691" modified="2010-08-10" version="1">MSDSIPISEEGFARLKQELEKLQAERPEVIQAIKEAREEGDLKENAGYDAARERQGLLEAKIAQITSRMPMFNIIDLDTMDGNKVCYGATVEIENVDTGEVKKYTLLGPDETDFVPDSLSVFSPLARALMGREVGDETVVNAPKGKIEYEILDIKFYGSSIFKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPJ1</accession>
    <name>D6SPJ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na+/H+ antiporter subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869987.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2039"/>
    <dbReference type="EnsemblBacteria" id="EFI34667">
        <property type="protein sequence ID" value="EFI34667"/>
        <property type="gene ID" value="Dthio_PD2039"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2051355at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="10626" checksum="0F37E6C43EAAD954" modified="2010-08-10" version="1">MIFDIFSIILCLAGAFFFLGGTVGLLRFPDTYSRLHALTKADNLGLGFIVLGLMFASASLPEIIKLGLIWLLALVGSSSACYFIGNYIYHMPSQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPR0</accession>
    <name>D6SPR0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870054.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2109"/>
    <dbReference type="EnsemblBacteria" id="EFI34736">
        <property type="protein sequence ID" value="EFI34736"/>
        <property type="gene ID" value="Dthio_PD2109"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="609342at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087911" evidence="1">
        <location>
            <begin position="34"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="46463" checksum="7D65F13ECD761E0C" modified="2010-08-10" version="1">MRSNVFFRPGKVITLLVAVSVVCMLCASSWALAGSNGSQPADVTGESVDEFEGGERYQAGEINILHLSGSYREMGRQYGRLLSKPMQDLYQSAIVEYFKKEKGLSSEDMLLAARGLYEFYPRRFKDIMEGMAETSGLSLEEHILLNALELYGTMSGCSAIFAWDDYTPGGQLIAGRNYDWFDSYTDFAESLTVTVFNPDSGVPATIVTFAGVIYATTGMNAKGLFLELNNALPSGGGLTYTNRVHAISNLMAFLFDYESMEQLDAAMNTTRSNFSYIINTADSRGAYSYEWPPFDLLRRSGDEPGLLVSTNHFVDPSWGLMQQEGTGFRSVERRDNLLEQARKYKGNIDLGKMKDMLDTPLEKGGPTWPDQGDIRTVYQVVAVPESLALWVKVPGFQDWIGIDLKSLFHEQGSEVRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPS0</accession>
    <name>D6SPS0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870064.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2119"/>
    <dbReference type="EnsemblBacteria" id="EFI34746">
        <property type="protein sequence ID" value="EFI34746"/>
        <property type="gene ID" value="Dthio_PD2119"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="118" mass="13487" checksum="983953F1B3D3BE57" modified="2010-08-10" version="1">METPFGSYVREKRLELKKTDKKYSLRQVAGRISVEPSYLSRIERGWPVPLSEAKIISLAGELGENPDLLLALSGKVSTEIQAIIRKRPELFTELIRELGEMPDHAVLRLVREVRDGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPT4</accession>
    <name>D6SPT4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870078.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2136"/>
    <dbReference type="EnsemblBacteria" id="EFI34760">
        <property type="protein sequence ID" value="EFI34760"/>
        <property type="gene ID" value="Dthio_PD2136"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="890258at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="526" mass="58742" checksum="5BC127227C7973E5" modified="2010-08-10" version="1">MQHYVLLDAIGIQKYIFDTNTLRIIIGASQFLDKWQQECSKRWPGNVLVSGGGNILAVFDNKTDADSFRKEAINIAPAGMEIAWANAEGKPGETGPGSDNAIWNELQKRISLFKSGNRDFSDYDQTFFQPVTPGCHYCGVRSRDGKGALDDYNNKKQPVCSVCRPRYDKGGRTGDVSTSMGKLWEYVGNKQFDPPFPLDLADLTRKENTAENVGEASHDLMAVVVVDLNDMGEKIKDVVNKEGFKGLNSFSQQLKLDIDEVFAALTDDFTPKSEWCGRKANDCFLRLRPLLLGGDDMALAMPAPLWPEFVNNLLRGLAGKGYPACAGVVVAKHTFPINRLVEMAEELVGSAKAMVRYRKKIAGESALSAEYQCAVDWHVHQETAFGSPLAIRKKHFVTKGLRFSRDHQAGEAIIQAATCRPYLLQDFSDLTETGRKLSVISNSKLFALYNALRSGCQATRDFLTYVLLRDDNEKLTSYSPVWAEVLKNQSKWPMWEDFSGPDMDVQACRTQMPDVLELLFLTRPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPX9</accession>
    <name>D6SPX9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870121.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2186"/>
    <dbReference type="EnsemblBacteria" id="EFI34805">
        <property type="protein sequence ID" value="EFI34805"/>
        <property type="gene ID" value="Dthio_PD2186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="233" mass="26365" checksum="3C6E96EDFDC37BFD" modified="2010-08-10" version="1">MEKPTKKSTIPALVLGGMLAYGTIGDKVNSEYQNTTQENAQLETAQTDYKASALENLTNALAPAKAFAQTNQNYQRPDDATLKQWMNQPVEETLAGTNYTKVNDHNYQREVKQADQPTMVLFYTDNPNTDGVNPSRGLVALTKTLHEKFPEIKFCAYKLSDRNTTPRNVYNHVTSEYPVEKTPSLLFYESKDFGSGTEIMPENWHMQGGIVTFDYLDGKIGDYYKHIPKNFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPZ8</accession>
    <name>D6SPZ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870138.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2212"/>
    <dbReference type="EnsemblBacteria" id="EFI34824">
        <property type="protein sequence ID" value="EFI34824"/>
        <property type="gene ID" value="Dthio_PD2212"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925819at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="65" mass="7269" checksum="BAE09DEDDC5DC6FC" modified="2010-08-10" version="1">MKVSYFDDTDTLYIEFRDSDIAETKDLDENTILDVDAEGNVCAITFEHASERTDVSHLIVEGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ22</accession>
    <name>D6SQ22_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease YjgP/YjgQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870162.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2239"/>
    <dbReference type="EnsemblBacteria" id="EFI34848">
        <property type="protein sequence ID" value="EFI34848"/>
        <property type="gene ID" value="Dthio_PD2239"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="355" mass="40529" checksum="36175D7DB11DE18A" modified="2010-08-10" version="1">MSVLNRYLLRQNLFYTAVLLFSGTMVYLIVDFVGRMNAMVEAGLGALQVLEYFVFKMPLIVAQTLPAIFMLGVLIQMAMMHRSNELVAMESSAISFRKPAVFFIGYALVVFMLLFVFSETLGVRGEQVTRQIWNQDVRDREAAVEGLEDVWVKDRDYMIHIERAHINEGRGKDFTAYKKSDPGKIQEIIKAPEFEVHKNRLLLRDVTVFKPHSLERQSLQEMEMEVKIDLRSFALVDSDLPYQAWSIFTLSALVNQLKESGASVEKISTALHSKIAYPFALVVMTLLALALFTRIKNIYALVTLGLVIVFFYYTVYVFGVSYAEEGVTAPFVGAWTANVFFGILSLLQLFWMDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ39</accession>
    <name>D6SQ39_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2256"/>
    <dbReference type="EnsemblBacteria" id="EFI34865">
        <property type="protein sequence ID" value="EFI34865"/>
        <property type="gene ID" value="Dthio_PD2256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="68" mass="7919" checksum="0E851BE0DA75A9E6" modified="2010-08-10" version="1">MLNAPMLRQIWDDALPVVLEEYARGHGEFNLDRCQAGPVKSRFIDLCMQTHVNTRYSLQIHKLQYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQA5</accession>
    <name>D6SQA5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase I</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD2323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Single-chain monomer with multiple functions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2323"/>
    <dbReference type="EnsemblBacteria" id="EFI34931">
        <property type="protein sequence ID" value="EFI34931"/>
        <property type="gene ID" value="Dthio_PD2323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="10">
        <location>
            <begin position="9"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="11">
        <location>
            <begin position="602"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="845" mass="95730" checksum="E75F9279D4D8CCEA" modified="2010-08-10" version="1">MIREKIEYKNEPVFLIDGSSFLYRAFYAYPDLKRSDGLPTNAIYIVIRMLLKIVKEEKPEYMGFFLDGKGPTFRHELYIPYKAQRPGMPEGLSAQIEPLREAVRILGIPEYTAQGLEADDLIAGYTEIFKSKHPVIIVASDKDLKQLLDDHVYLWDPGAKNAEILDCDGFRRETGIGPEQWPDYQALVGDSSDNIPGIPGVGPKTALNWLKKFPSLEELQAGLDELKPKEQEKLREHMDDVFLYRRLTKLKPDCLSGAGLETLKTRPADPVELQKFLDEYEFKSLKNEIPGSQELKHEQSREKGGVQKAWAEKEELPDCRGQITGLYLGQDSYLVALEDQEWEVSKKTPPIEKLEFCKKYVFSLKDLYRENQDWMQEPVSGFFDISLGVYLLNPEERDYSFDRIFRTYAPEIAVHRENRAVAALKIGQMVEKRLDAAGLLGLMQELEMPLVPVLCRMESAGIGIDLAAFDNFLRQVKKSLDDLTASIYSLAGKEFNIRSTQQTAQVLFDELGLKARRKTPKGAYSTSNVVLESMRRDHDIVDLILQYRTLEKLRSTYLEPLPRKVDVGGRLHTTFNQLATATGRLSSSNPNLQNIPIKGEFGPRMRACFKPSKGKLLVAADYSQIELRILAHMSMDPNLLQAFGGNEDIHRRTAGLLFDKDIQEVSQDERRKAKTINFGLLYGMGPQKLSRELSISMEEAKEFISVYFSKLDRVRDFYQQIEEKAQEQGYVTTMAGRRRLLPDINSRNTNMAQQARRTAVNTVIQGSAADVIKKAMLAVDSDSELRSLGSVMVLQVHDELLLEVDAPVAQKAGERLARVMAGVESLEVPLLVEWGTGENWAEAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQC8</accession>
    <name>D6SQC8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2346"/>
    <dbReference type="EnsemblBacteria" id="EFI34954">
        <property type="protein sequence ID" value="EFI34954"/>
        <property type="gene ID" value="Dthio_PD2346"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="127"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="251" mass="29023" checksum="B4BE9CBB1317BC6D" modified="2010-08-10" version="1">MSEDKYSLSSRSAEMEQDQEEDEPKNWITIFADIALLLLVFFVLLFSFSTLSDEKFRETILSVRESLGREETEDWGMRVRTDTSGVLMDRATQFRQLQEAQQETFADIQYYQNEHGIEGIVGARLDEGKITLTLPSEVLFDLGEVELRPEGEELLQDMRDIFNRHSEQRINIEGHTDNIPPREGGRFEDNWEISSLRALNTLRFLKQEGIDPGRMTATGYADLQPLYPNTTEGNRARNRRVEFVLERHIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQD2</accession>
    <name>D6SQD2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA/rRNA methyltransferase (SpoU)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870272.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2350"/>
    <dbReference type="EnsemblBacteria" id="EFI34958">
        <property type="protein sequence ID" value="EFI34958"/>
        <property type="gene ID" value="Dthio_PD2350"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1637132at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="252" mass="28333" checksum="C609AC85C9676B98" modified="2010-08-10" version="1">MNNIAVILCRPKYSENVGSVARACINMGCSRLIIAGSQTFDPQRAAPLATSRGAELLRSTEHYPNLEQALKGFHRVFATSARVGGWRKGVFLPWQAAQEIMRPETLDQDTALVFGPEDKGLANHEIELCPRIISIPTTSQAWSLNLSQAVLLVLYECFKHVPAARTRHIPSWDSPPVTQEQMQLLHQNIQETLLLIDFLQPDNPDYFMLPLKRFLAKTGIRQHEFNLLMGICRQIKWMAGRLPPGPASRSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQF5</accession>
    <name>D6SQF5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870295.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2373"/>
    <dbReference type="EnsemblBacteria" id="EFI34981">
        <property type="protein sequence ID" value="EFI34981"/>
        <property type="gene ID" value="Dthio_PD2373"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1613263at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="156" mass="17977" checksum="4D05A91413353937" modified="2010-08-10" version="1">MAGFFKAAEIVEAAVNIEQQGQAFYTRAAEAAKNPDAKDFFLYFAKEESRHEEIFAKFKERLGKTELPAWSTSDEYSQYLSALIDSHSIFSPDLQKRLTEAGDENEAIRLAMGFEKDTILFFMEMRELVPESEKKFVQQCIDEERSHLRQLSSMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQH3</accession>
    <name>D6SQH3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tsf</name>
        <name evidence="9" type="ORF">Dthio_PD2391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870313.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2391"/>
    <dbReference type="EnsemblBacteria" id="EFI34999">
        <property type="protein sequence ID" value="EFI34999"/>
        <property type="gene ID" value="Dthio_PD2391"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="8">
        <location>
            <begin position="52"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="200" mass="22308" checksum="256D9080AEF9C02A" modified="2010-08-10" version="1">MVDAQKVKALREKTGAGMMDCKKALQDSGGDEEKAITWLREKGLSKAQKRAGRATSEGWIGSYIHSNGKIGVLVELKCETDFVAKSDQFQQLARDLAMQIAATSPVCVNPEDLPQELVDKERDFYKSQAEKEGKPEHIAEKIVQGRLDKYYKEVCLLKQAYIKDDSKTIEDLINDTVVVLGESIQIGRFTRLGLGEDVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQI1</accession>
    <name>D6SQI1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2399"/>
    <dbReference type="EnsemblBacteria" id="EFI35007">
        <property type="protein sequence ID" value="EFI35007"/>
        <property type="gene ID" value="Dthio_PD2399"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="11612" checksum="D3D3352B9CD27421" modified="2010-08-10" version="1">MNKILLDTNAYTAFLRGSYQVLDALGQAEIVFVSIIVLGELEAGFKGGSKEEINRDLLRRFLAKPSVRVLNATFPTAMIFGRIKSELKHAGTHYPSMTSGSRHMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQI5</accession>
    <name>D6SQI5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870325.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35011">
        <property type="protein sequence ID" value="EFI35011"/>
        <property type="gene ID" value="Dthio_PD2403"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047570at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="9314" checksum="4C0AD42BFC5C4869" modified="2010-08-10" version="1">MSNITFKADDEVIKKARKVAIDKNTTLTRMLREYLVSLARLEDEKKAVALSRLEKTFERHSRDMGRREWSREDLYEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQK6</accession>
    <name>D6SQK6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsU</name>
        <name evidence="6" type="ORF">Dthio_PD2426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870346.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2426"/>
    <dbReference type="EnsemblBacteria" id="EFI35032">
        <property type="protein sequence ID" value="EFI35032"/>
        <property type="gene ID" value="Dthio_PD2426"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7871" checksum="F6D430B3024BEB82" modified="2010-08-10" version="1">MPGVILGESDNFDYALRKFKKQVEKSGILSELKKRQHYEKPSIQKKKKEAAARKRLMKKMRKMQMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQK9</accession>
    <name>D6SQK9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor RpoD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sigma-70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoD</name>
        <name evidence="9" type="ORF">Dthio_PD2429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870349.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2429"/>
    <dbReference type="EnsemblBacteria" id="EFI35035">
        <property type="protein sequence ID" value="EFI35035"/>
        <property type="gene ID" value="Dthio_PD2429"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007631">
        <property type="entry name" value="RNA_pol_sigma_70_non-ess"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04546">
        <property type="entry name" value="Sigma70_ner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="354"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="433"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="522"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="378"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="588" mass="67789" checksum="3D604876949C80B7" modified="2010-08-10" version="1">MRSIKDVQQIKALIAEGKKKGFLTFDEINKALPSDVTTPEQVEEIISIFDQLDIAIVDGKAGKTISVSSEDTNSLAETLALNLDRLEDTAEAVSRSNDPVRTYLREMGAVGLLDRDGEVVIAKKIESGEMEVLYSLVEVPVAIEELIQVGEDLKKEKIKLKDVVKTIEEDDPTEEEMNQRERVIALLEEIKQCYKKRRSVYEKLNECARLDRRVYGQQKKILDYKYEIVEHLKHIKLEKTLIDSIIERVNDYVRQMHNCQRDLSAYILSLGMSQDELHSLLNKLHNREINPVAAADQLGMTVDELFSFKELIYGKMEIQERLQQRCMHNVHELEEILWRINKGNEEALRAKQELIRANLRLVVSIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYQRGYKFSTYATWWIRQAITRAIADQARTIRIPVHMIETINKLVRTSRYLVQELGRDPSPEEIAERMDYPLEKVKKVLKIAKEPISLETPIGDEEDSSLGDFIEDKKAVAPADEVVNSKLSEQISKVLAELTPREEQVLRKRFGIGEKSDHTLEEVGKLFNVTRERIRQIEAKALRKLRHPVRSSSLKTYYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQR5</accession>
    <name>D6SQR5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD2485</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870405.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2485"/>
    <dbReference type="EnsemblBacteria" id="EFI35091">
        <property type="protein sequence ID" value="EFI35091"/>
        <property type="gene ID" value="Dthio_PD2485"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="4"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="412" mass="43632" checksum="10FB49CF1177E9C4" modified="2010-08-10" version="1">MPRVVVTGLSALTPIGNDLDSSWENLLAGKSGVDHLARFDCTGYASRIAAEVRDFDPTAYMSAKEAKRMDRFCHLGVAGAQMLMQDSGLTPDNMDMEQCGVLLGCGLGGLETIEEFHSKLIKSGPKRVSPFYIPLLIANMVAGQISISTGAKGPNLVTTSACASGMHAIGYAYSDIRLGRAQAMITGGVESTITPMALSGFSAMKALSTRNDDPQKASRPFDKDRDGFVIGEGSGQMILESLDSALARGARIYAEVVGFGATADAFHITAPDDSGEGMASCMKQALREAGVSPEQVDHINAHGTSTYLNDITETRAIKEVFGKHAYDMLLTANKSMIGHTLGAAGGIEGVFCAKSLYHGQVPGTINLDTADPDCDLDYCSRGSVTRSINFALCNSFGFGGTNGCILFKRFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQS9</accession>
    <name>D6SQS9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">8-amino-7-ketopelargonate synthase</fullName>
            <ecNumber evidence="7">2.3.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870419.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2499"/>
    <dbReference type="EnsemblBacteria" id="EFI35105">
        <property type="protein sequence ID" value="EFI35105"/>
        <property type="gene ID" value="Dthio_PD2499"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="9">
        <location>
            <begin position="39"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604723-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="388" mass="42775" checksum="1F66CE1DF0B0F20B" modified="2010-08-10" version="1">MTTKHYPPPGKKMPQSHERSIPAVDHGPDLYLDFQGQRLLNLASNNYLGLAGSKEMKEASIRAVEEFGTSSGASRLISGNYSLYTALEEELCRFKGTDAALVFGSGYAANLGILSTLAHRKCLVFSDRLNHASIIDGITLSRATHVRYRHADPEHLEYLLAQKPVQAPKILITDTVFSMDGDRAPLPEILNLCKKYRVLTIADEAHATGILGRGRGLVHELDLEQEMDLHMGTFSKALGSYGGYVAGSRELIDLLVNRARSFIYSTSLPPAVVGACLEALRQVQASPQQGEKLLDLSRQIRSFLQRLGYDTGKSTTQIIPVIMKKSRAVLQAREDLVRAGIYAGAIRPPTVPEDSARLRICLRADMTHKEIEVVQKAFSTISARQYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRA0</accession>
    <name>D6SRA0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0542"/>
    <dbReference type="EnsemblBacteria" id="EFI33216">
        <property type="protein sequence ID" value="EFI33216"/>
        <property type="gene ID" value="Dthio_PD0542"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZVX0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010712">
        <property type="entry name" value="Arsenical-R_ArsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06953">
        <property type="entry name" value="ArsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="10850" checksum="2DB1C1272EA1C8DB" modified="2010-08-10" version="1">MACACTPGSPAGDRKTQRLQDALLELQNDFNVSCMVYALNMHLQQFRSRPELAGILQNQGKKGLPVIFINDRLCFQGEYPDRAQLEEALKKYGDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRB2</accession>
    <name>D6SRB2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870586.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0554"/>
    <dbReference type="EnsemblBacteria" id="EFI33228">
        <property type="protein sequence ID" value="EFI33228"/>
        <property type="gene ID" value="Dthio_PD0554"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033FWH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1886092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13625" checksum="AA6D1CE82E497FD4" modified="2010-08-10" version="1">MQKIPLKMAAAGMVLEKPVVRDNGQVLVGAGTELTESLLERLERMEVEWVTVQGNPVNMEGLGTSSYQDRIRALDRIFRQHEQDPWMMKMKKFLRGYFKRKAAQQTSQGPAKDTETEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRD2</accession>
    <name>D6SRD2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870606.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0574"/>
    <dbReference type="EnsemblBacteria" id="EFI33248">
        <property type="protein sequence ID" value="EFI33248"/>
        <property type="gene ID" value="Dthio_PD0574"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360776at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021923">
        <property type="entry name" value="DUF3536"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12055">
        <property type="entry name" value="DUF3536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="103"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="721" mass="83714" checksum="3617787F99C7A2F6" modified="2010-08-10" version="1">MPQYLCIHGHFYQPPRFDPWLEEVLPEASAAPFPDWNQRINRESYDPLGAARILDEHGRIERIVNCYEFINFNFGPTILRWMARHSPSTYHKVLEGDRKSIERFGRGNAMAQIYHHIIMPLTTDEDREVEIQWSIQDFQQRFGRRPEGFWLSETAVSTPDLEALARADIRFTVLAPRQAKAISDSRGNWHEVDEGTLPKDRPYLVKLPSGREVSVFFYDGPVSQAVAFENLLSDGEGFWQRILANHDQKLLSLATDGESYGHHFKFGEMALAWVLNRALQEDSPLSLTNFSSCLDKHPPQQEVRIHEKSSWSCVHGIERWQDDCGCSSGDHPGWNQLWRRPLRRSLNVIRYYVDEHYRHYAGELFSDPRQAMLDYGNCLSGKVERDEFLRRHQARDLDRNQRAVALKFLEMQRMSLASFASCAWFFDDLGRIEPLNALSYGSRALEMLKDLQGPDVEPLVLEVLEEARSNDPAIGDGVTIWKEKVLPRRVRPAHMAVMGACMQDRESSFSFPGLEFSTRKEKNILQLDYSWTCLQEQGQEKFALDQEASLDCRVQTGEGKSLGIRDLDKKLRDLMLLKLDRQHEQKVLSDMIQAASILGRHRESFFETGQKEPIAGRGILSLGMLMHYLFSTEDPDDWSAFWQEVLQNNPYLAFLLKSMLEKELERLCSEKLQMWERAGEMIQRSRKIGIHPDIYHLQNRIWEKGLESWGKNTLKLFDFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRI1</accession>
    <name>D6SRI1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870655.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0623"/>
    <dbReference type="EnsemblBacteria" id="EFI33297">
        <property type="protein sequence ID" value="EFI33297"/>
        <property type="gene ID" value="Dthio_PD0623"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="13520" checksum="C311697E13AC7690" modified="2010-08-10" version="1">MARVLIVEDSVFQRTILKRIVQQSGHEAVEAASGREGLRKIDELQPDLILLDLLMPDINGFQVLQVLESKHVKTPVVVVTADVQETTRQKCQEHGVVELVNKPVNDEKMFEVLNNHLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRM6</accession>
    <name>D6SRM6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870700.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0670"/>
    <dbReference type="EnsemblBacteria" id="EFI33342">
        <property type="protein sequence ID" value="EFI33342"/>
        <property type="gene ID" value="Dthio_PD0670"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033C3D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2059197at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7545" checksum="680E65E05234C351" modified="2010-08-10" version="1">MKMKEIRDLARERSVKLPYAVSKVQAVRLIQIAEGNSDCFARVVEGECDQHGCLFYQECLKLSPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRQ1</accession>
    <name>D6SRQ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding lysin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870725.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0695"/>
    <dbReference type="EnsemblBacteria" id="EFI33367">
        <property type="protein sequence ID" value="EFI33367"/>
        <property type="gene ID" value="Dthio_PD0695"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149768at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="388"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="538" mass="60381" checksum="4A17D25F3B62FE98" modified="2010-08-10" version="1">MDYYKLLQLAREPFANTPDPDMFYPANQHAHCLQKLEVAVRLRRGLCVVSGEVGTGKTTVCRYLYRYLSGDDLFCTHLVLDPCFENSSDFAARLNQELNGREASLGCSSQCQHKEQIQEFILRLGEEEGRIVTLIIDEGQKLSEDCLEFLRELLNFETNEHKLLQIIIFAQDEFLDILKQMPNLQDRVALHYRLEPLSRKDTTSFILHRIQASSTDPSRPPAVTFSLAARRLIYKMTRGYPRRIIHLGHNILLTLVMLERTRITRKVVHRAADSVSSREIPRRSSRPLALAAGTVAVLLALGLLYQAGHLEQAKSRWLAFIASHYDAGDPPSQDSSRYRAPVSPAPDSSPDQQDRPVPAYSLTAKNSPDNDSQPVSTLDASADRDTLGKVTVISRESLWTLADAVYGRGSVAAVQQVAEANPWLTNPDIIHAGQQITLPVISLKSPSSKQQVWIRLAWARDLDQAYQQAYNAGLDSFRVLALNDAQAGFAFWVVHRESFDDPSSARQVLDSKSSSLIQEAEIVSLEDFDRTWKLAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRR3</accession>
    <name>D6SRR3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870737.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0709"/>
    <dbReference type="EnsemblBacteria" id="EFI33379">
        <property type="protein sequence ID" value="EFI33379"/>
        <property type="gene ID" value="Dthio_PD0709"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335SC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063281at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="8137" checksum="7C76E09594A69A06" modified="2010-08-10" version="1">MSPIETDHETIKRIFKESLAETLHENRQLFEEIITDVFEDLALSEAIKEGKETEKVSREEIFRTLEQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRT6</accession>
    <name>D6SRT6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870759.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0733"/>
    <dbReference type="EnsemblBacteria" id="EFI33402">
        <property type="protein sequence ID" value="EFI33402"/>
        <property type="gene ID" value="Dthio_PD0733"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2089806at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038733">
        <property type="entry name" value="Predicted_DNA_bind_prot_RHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12651">
        <property type="entry name" value="RHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8555" checksum="9B97A093487C4F6C" modified="2010-08-10" version="1">MKVKTSITLSKDIVEKIDSLSESYGNRSTLIEKAVRDLIAAREKLDRDQSDLEIINKQADTLNSEAIDVLSYQVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRW3</accession>
    <name>D6SRW3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Toxin CcdB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cytotoxic protein CcdB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein LetD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CcdB toxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870781.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0763"/>
    <dbReference type="EnsemblBacteria" id="EFI33429">
        <property type="protein sequence ID" value="EFI33429"/>
        <property type="gene ID" value="Dthio_PD0763"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YCB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2075946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008657">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002712">
        <property type="entry name" value="CcdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01845">
        <property type="entry name" value="CcdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="100" mass="11158" checksum="8B23C535A2F3B8EF" modified="2010-08-10" version="1">MPQFDVYKSRSKKVELLLDLQDDMLKNLSTRVVAPLVPPNMLTPRMNIVNPVLILNGREYILLTHLLAAVKSNTLGKNIGSVSEQRNQIVAALDMLFTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRY4</accession>
    <name>D6SRY4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rex</name>
        <name evidence="8" type="ORF">Dthio_PD0784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870802.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0784"/>
    <dbReference type="EnsemblBacteria" id="EFI33450">
        <property type="protein sequence ID" value="EFI33450"/>
        <property type="gene ID" value="Dthio_PD0784"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1872374at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="7">
        <location>
            <begin position="82"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="93"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="217" mass="24306" checksum="C35ACB832A081CED" modified="2010-08-10" version="1">MQQLKFERIPRATISRLAVYVQELEVMEQQGIKVISSEKLAQLCGVNPSQIRKDLAYFGEFGVRGVGYYVHELREAIRQSLGLDRTWNVVLVGVGNLGRALLRHNLLRKRGFVIVAAFDCDPFKIGEEIAGLEVNCTSKLPKSTRDMNVEIGVITTPPERAQRAANYLMEGGIKGIVNFAPSRITTPENISVEYVDFIHHMFSVAFNITQNQSKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS37</accession>
    <name>D6SS37_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD0837</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870855.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0837"/>
    <dbReference type="EnsemblBacteria" id="EFI33503">
        <property type="protein sequence ID" value="EFI33503"/>
        <property type="gene ID" value="Dthio_PD0837"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="333"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="408"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="479"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="727"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="850" mass="96857" checksum="B3C3592B1AA53143" modified="2010-08-10" version="1">MSAIYILSRNQGLQKLVEEICQAYFPESSVRVLEPGELEDLMVHSEINVCILDEQVVRDYQDGPSLALRKKFHESGFSILMLYQDEEPAKLAGEVQADSVLNVTCSRGEFKSRLEHLFLISELRAMNLNLRAQLDWRVNRMDTLEQELWHTNTILKALSRCNEIIIKADDEQTMLQNVCQTISSQIGYPLVWVDYARRDSEQSVKIMASSGPKKDLVKVIKINWNESPYGQGPTSRAIKTGQPVHIEDVSKDPCMHCWSELFMKEGIREILSLPIAYSGVGFGALTITSQSSGSFAGKTREYLESVARNMGYGVWFLRHRAKRKQVEKELQKTNEIFTLAMEATQDAIWDWDIRSGTTYFSPRWYTMLGYEPYELPQNYDSFLAVIHPADKDEVKKQMDGFLRQSENFSIEYRAVSKNGETLWILTRGKVVQSDEQGRPLRMAGTNVDMTERKLMEQELSQAKKSAETANRAKDRFLENMNHELRTPLNGIMSVLQTLADSELKPAEKEYVEMALNSSSQLLASLNKILELSSLQDDIQQVHPQPFVLHEEMSKLVSFFQPQARNKQIGLELDIQEDVPSWLVSDVGMLRQIVWNLVDNAVKFTHEGKVVLRISKQSDSRQDSEATTVPLLFEVEDTGGGIPHEMQKDIFEPFVIGEHDIQFKRYQGTGIGLSVCRQLVRSLGGETGVESRKGLGSTFYFILELEPGRETEEDLPEYEEILNPENKCILIVEDEKINLMLIRRMLQKKGFNVLTAMDGREALEVLKSNQDISLILMDVMVPVHDGYELTRMIRKGDFDGLKQVPIVAVTALADAASRQHCFEAGMNAYLSKPVDNSELMKMIRRYLARSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS38</accession>
    <name>D6SS38_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent RecD-like DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recD2</name>
        <name evidence="3" type="ORF">Dthio_PD0838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecD family. RecD-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870856.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0838"/>
    <dbReference type="EnsemblBacteria" id="EFI33504">
        <property type="protein sequence ID" value="EFI33504"/>
        <property type="gene ID" value="Dthio_PD0838"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="961809at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01488">
        <property type="entry name" value="RecD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006345">
        <property type="entry name" value="DNA_helicase_RecD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029493">
        <property type="entry name" value="RecD-like_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041451">
        <property type="entry name" value="RecD-like_SH13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14490">
        <property type="entry name" value="HHH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18335">
        <property type="entry name" value="SH3_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01448">
        <property type="entry name" value="recD_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="338"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="722" mass="80542" checksum="2701FE550DEEE2C4" modified="2010-08-10" version="1">MKEIKAEVISLTYTNSNNGYAIARVKASGEPGQVTVCGYMGNLVPGETLQLKGEWKEHPKYGRQFMVQEFEQVFPASISGIKRYLASGMIKGVGPVMAGKMVAAFGEKVLDILDSDPDRLLKVEGIGVKKLDKIKASWSQQREIRNLMLFLQTYEIPTTFAARIYRKYGGEAVQQLKDNPYDLVYDIRGIGFKTADRMAIKLGLPPNSRERLQAAIAYQLFSLGEQGHLFYPAQELLEKVLELLGEVSLDDVQAALDSLVEKKRVVVQDLPEQGITRAVYLSYYYKVEQDLAQRLCSMSTHPAALSGEKVEAGLEQLERQERIRLTPEQRQAVLDGCLNKTFVITGGPGTGKTTITRMLVRTFSALGLKIKLAAPTGRAAKRLSQATGAGAATIHRMLGFNPSGGFEHNEDNKLKADAVIVDEVSMLDASLTVQLLRALPVTCRLVMVGDVNQLPAVGPGNVLKDILDSETVPRAVLTSIFRQARQSSIVVNAHRLNTGKFPVSSDKKPPQADFFWVQQDDLAKIQELITYMVCQRIPAVYNLDPLKDIQVLTPMHKGDVGTAELNRLLQDRLNPGPDAVVRGYRRFRVRDRVLQMRNNYEKDVYNGDLGWIREVNLEDSELMVDFDGREVVYDLDELDELTLAYAVSVHKSQGSEYPAVIMPVVTQHYLLLQRNLIYTGLTRARELAVLIGSSKAMGMGLRSTGASRRYTHLRYRLQKAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS95</accession>
    <name>D6SS95_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="10">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trmFO</name>
        <name evidence="12" type="ORF">Dthio_PD0895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870911.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0895"/>
    <dbReference type="EnsemblBacteria" id="EFI33561">
        <property type="protein sequence ID" value="EFI33561"/>
        <property type="gene ID" value="Dthio_PD0895"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="516534at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="11">
        <location>
            <begin position="5"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="442" mass="49406" checksum="5E6870A2431FCF3F" modified="2010-08-10" version="1">MNQSIAIIGGGLAGCEAALQLARQGVWVTIFEMKPQKYSPAHESQSLGELVCSNSFRSMEPVTGVGLLQQEMHRLGSLVMEAALMHRVPAGKALAVDRDRFAQHLTSRVEEHEFIRVHRREIQDLDDPELQGFDAVILSAGPLISDPLAQSLFRVIGAQDLYFYDAIAPIVSAESIDYDKAFWGSRYRPEDDDYLNCPMSEEEYYRFYHELVGAEKVPARDFEEEKHFQGCMPIEAMAEKGELTMAFGPLKPVGLVNPRTGEQPFAVVQLRAENLEKTAFNLVGFQTRLKLGEQKRVFSMIPGLENAEFLRLGSMHRNTFVNAPQVLTRNLELKARPGVYLAGQISGVEGYLESAACGLWLGLRLGLEARGIDPPAPPRDTALGALMNHLQSDARYFQPSNIHFGLFPPLKARAKKARRKELHAQRAQESFDKWLSRLGAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS96</accession>
    <name>D6SS96_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870912.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0896"/>
    <dbReference type="EnsemblBacteria" id="EFI33562">
        <property type="protein sequence ID" value="EFI33562"/>
        <property type="gene ID" value="Dthio_PD0896"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1000375at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="entry name" value="PTHR31970"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="399" mass="42133" checksum="582CD7B6666F4CE7" modified="2010-08-10" version="1">MGVPYKFNRQELAGSLGDLGVVLPLGIAMILVNGLNPLGLFFSVGLFYLLSGMYYRIPVPVEPMKVIGAYAVATGITASEIMASSLLIGVLLLVIALTGAMTLIGKYTPKEVVRGVQLSTGLLLMAEGVRFMIGTSTFQKLQEAAEPYLVIQDIGPVPFGLVLGLVGGVVTLLLLDNKKLPAALVVVLGGMLVGLLLGTREGLSQVSPGFNLPEFMPFGFPSGVDFSFALLVLVLPQLPMTLGNAVIANVDLSRQYFGEAAHRATYKANCITMALANFFSFFVGGMPLCHGAGGLAAHYRFGARTPGSNVIIGAIFIFLAVLLGVNILGILYLIPMAVLGVLLVFAGSQLALTIMDLKERKEFFVVFTIVGITLATNLAAGFIVGIIVAYILKSEKLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSB1</accession>
    <name>D6SSB1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0912"/>
    <dbReference type="EnsemblBacteria" id="EFI33577">
        <property type="protein sequence ID" value="EFI33577"/>
        <property type="gene ID" value="Dthio_PD0912"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="181" mass="19940" checksum="0AC8F81B6DBF17EB" modified="2010-08-10" version="1">MVEAAQLFGCGGEMDWSSMFDARVVVFGCGNTLYGDDGMGPLAIKALQDRGDLGQEVACIDAGTSIRPLLFDLILSDKHPEQVIIIDTTTDDDIKPGEVREIDISRVDPKKISDFSMHQFPTTNLLKELQETTDIKLSIIVVRAAHIPEKMQEGLSPEVQKALDEVQTKVLQLVNSEVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSC3</accession>
    <name>D6SSC3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rny</name>
        <name evidence="8" type="ORF">Dthio_PD0924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870939.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0924"/>
    <dbReference type="EnsemblBacteria" id="EFI33589">
        <property type="protein sequence ID" value="EFI33589"/>
        <property type="gene ID" value="Dthio_PD0924"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1012190at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="335"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="519" mass="58735" checksum="65DCC695CCFF0E2F" modified="2010-08-10" version="1">MWTTVIITALIALAVGAVAGFWAQKIFFNKKYQENQELAQRILDEARKEASAQKKEILLQAKDEAFKQKKELEEDAREREKELKKQEQRLQEKEERLENKLEKVAQKESEVVAWENQLTKQERTFAEKEEHLQELIDNQSKKLEEISGLTTEEARHRLMQEIESKTRHEAARMIRQIEMEAQETASKKAREILALSIQRYAGDYVSEHTVSAVELPSEDMKGRIIGREGRNIRAIEAATGVDLIIDDTPETVVLSAYSPLRREVAKQSLERLISDGRIHPARIEDIVEKVKKELDVKLREIGEQATFDVGVHGIHPELIRLLGHLHYRTSFSQNVMQHSIEVAFLCGIMAAELGLDQKKAKRAGLLHDLGKAVDHEVEGPHAIIGADLAKKHNESKDIVHAIAAHHEDVQPASILAVLVQAADSLSGARPGARKELLENYVNRLEELEKIASSFNGVNRSFAIQAGRELRVMVDCDHVDDDATHLMCKDIAQKIEESITYPGQIKVTVIREKRSVGYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSJ3</accession>
    <name>D6SSJ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871008.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0995"/>
    <dbReference type="EnsemblBacteria" id="EFI33659">
        <property type="protein sequence ID" value="EFI33659"/>
        <property type="gene ID" value="Dthio_PD0995"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="591335at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="402" mass="47331" checksum="1494BA549FF2F622" modified="2010-08-10" version="1">MPEFKPLQFYSYDWSRQDIDPEKVISPPYDVLSQEDIQELARDEYNVVHIDSPVSYAHARELLDQWIKKQVLTADQQPRYYILASEYKTRGRSRTRWGIMGGLRLEPFGENVFPHEETYPKAKEDRLKLMQATQGQLSPVFGVYDDPEQYVEKIGEICSGQKPLISFTQEDGVYNRLWPVPAEHNQQIQSLMQDRKIFIADGHHRYETSLYFMHNQPARDNAPWEYIFIYLSNISSPGLEIFPYHRTVSWDKEFDWQKVMQSAGRYFDIIPREDHSFPEEMPRTDMLMLCLPHINYLLIPRQPGEDIFDKIGAYVLDRVMLRDIMGLDDEQLASGKYLHYTHEEDLTLEKVRSGELQAAFFLQSVPINIMQEACQAGRVMPRKSTFFYPKLPTGMLLHLWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SST0</accession>
    <name>D6SST0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871095.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1085"/>
    <dbReference type="EnsemblBacteria" id="EFI33746">
        <property type="protein sequence ID" value="EFI33746"/>
        <property type="gene ID" value="Dthio_PD1085"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="451517at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="3">
        <location>
            <begin position="137"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="468" mass="51876" checksum="8A361511587837A0" modified="2010-08-10" version="1">MANVLIIDDDPDVRQVLAGAVKSAGHEARSAGTLQIAMDTAGSFNCEAVFLDLSLPDGHGLDALTWFQELMSFPEVIIITGKGDPAGAELALNKGAFDFLEKPASIAEVTLTLVRALEYREARLRRSREGLIKRSGIVGSCSALVRCLQDLSQAAATGNSLLIFGETGTGKELFAKAVHDNSPRAGHDFVVVDCSALSRGVMESTLFGHVRGAFTGASDNFSGLVALSNKGTLFLDEIGELDLDMQKKFLRVLEEKKFRPVGASREVYSDFRLVCATNRDLEAMAQRGEFRQDLLYRIRMQKCTLPPLRERREDIPELCTHFLEETAGQLKASPKEMYPEVLEIFSAYEWPGNVRELKNALEQAAAAAQDEPMLHRRHLPLHLRVSLLKDSLSGQQEDKGVLSSDFSPLGQSDIPEWKTFKTQVVEAAEERYFHDLYAHTGGRIKEMARLANLTQSRVYSLINKYKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSU8</accession>
    <name>D6SSU8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, NifA subfamily, Fis Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871113.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1103"/>
    <dbReference type="EnsemblBacteria" id="EFI33764">
        <property type="protein sequence ID" value="EFI33764"/>
        <property type="gene ID" value="Dthio_PD1103"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="199"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="510" mass="58313" checksum="AAE2143495CAC018" modified="2010-08-10" version="1">MKENNYLVALENLLMHHGWQGPLREGLEKLLQATADEMGYRRISLAIFDPKTQSIEFSLYIGFTKTPKYSYTPGQGIIGQVVKEQSPIIVPLMKDDPNFLNLAFDRTPEELASMSFISVPIKRHSQENETEILGVLNAEMDLRDLPELETNCRFLQVLGMFIARQTSFLQEEVSRQKELPQFTTAEINTARQSMSESQLISTSKVMNMIMNQVMQVAPSRATVLIRGESGTGKELLAEAIHRMSPRKDKPFIKLNCASLPGELLESELFGYERGAFTGAVGQKKGRFELAHLGTLFLDEIGELSAEAQAKLLRAIQAGEIQRLGGEKTTRVNVRIVCATHQPLENRIEEGAFREDLYYRINVFPIFIPPLRERREDILPLAEHFLQTFSREYEKNIKRISTPAIDLLIQYHWPGNVRELRNCMERAVLMCSEEVIRTYHLPPTLQTAESTATDTELPFVETVARFEQELIIDALKKARGNMLQAARDLKVSYRIINYKVKKYRINPKRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSV3</accession>
    <name>D6SSV3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, BadM/Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871118.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1108"/>
    <dbReference type="EnsemblBacteria" id="EFI33769">
        <property type="protein sequence ID" value="EFI33769"/>
        <property type="gene ID" value="Dthio_PD1108"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="143" mass="15927" checksum="198D094E7C4A5508" modified="2010-08-10" version="1">MKLSTTIRYGTRLMLDMAEHNETGPIRIKTIAQRQGISEKYLEKIVRLLRKAGLVDGLRGPGGGYVLAVPPEKITMGAILEAVQGRIELCPCLGEPEHCEKHMYCKTRMVWNDINAAVSSRLHSITLADLRDSTCPVDTKEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSZ8</accession>
    <name>D6SSZ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KpsF/GutQ family protein</fullName>
            <ecNumber evidence="8">5.3.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871163.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1153"/>
    <dbReference type="EnsemblBacteria" id="EFI33814">
        <property type="protein sequence ID" value="EFI33814"/>
        <property type="gene ID" value="Dthio_PD1153"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="571638at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019146">
        <property type="term" value="F:arabinose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004692">
        <property type="entry name" value="KdsD_KpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="36"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="205"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="271"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="327" mass="34996" checksum="4A64A2C6020950BD" modified="2010-08-10" version="1">MSENNDWLKKAREVLDIELEAIRAVRDDLDEAFSSAMEEMSACSGRIVLTGVGKSGLIGRKMAATFSSTGSPAFFLHPVEGAHGDMGMLRSEDLVVAISNSGETEEVNSILQSISSLGIRIVALTADTGSTMARLADVVVRVKVPREACSLGLAPTSSTTAVLAVGDAMAIALMQSKHFGKKDFQRYHPGGFLGQRLRQGIHRLMHTSALPLAREDESLENALEVMNQGGFGVVFITSGDNRLAGVITDGDVRRMVCGNNWRLSDPAGLHMISSPVHANPGQSAASVLDVMEEKAITVLPIVDHENRIKGLVHLHDLLGKGKLKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST16</accession>
    <name>D6ST16_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871181.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1171"/>
    <dbReference type="EnsemblBacteria" id="EFI33832">
        <property type="protein sequence ID" value="EFI33832"/>
        <property type="gene ID" value="Dthio_PD1171"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="4">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12447" checksum="851ABCFF493B7D9F" modified="2010-08-10" version="1">MRKLIILAMAGAIFATQVGIGLAMFDGNPRQGRFLFREQCRPCHMEDATKEGAAGEYLGPDAKRQAEWEEVFGDIEALPCYDEWDLSEDELNHIGTYLHQGAADSPTPERCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST30</accession>
    <name>D6ST30_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871195.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1185"/>
    <dbReference type="EnsemblBacteria" id="EFI33846">
        <property type="protein sequence ID" value="EFI33846"/>
        <property type="gene ID" value="Dthio_PD1185"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034AME">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1978493at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="159" mass="18179" checksum="0EFB9E4DB454ACF7" modified="2010-08-10" version="1">MDMDKDLASAMVSQRCNCYDSALESAKKVVAKENLPPDQIEATRNIVKSLGAWYFRQHCMEKIMECYDLLQRLPRVDSEKTSDKSDSLRGHEGSSRQICTALSPDVQEIFEALGQLEENRNKDEAELLREAVNLLILKYSMEESIRDKVLSKAEKLFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST43</accession>
    <name>D6ST43_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871208.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1198"/>
    <dbReference type="EnsemblBacteria" id="EFI33859">
        <property type="protein sequence ID" value="EFI33859"/>
        <property type="gene ID" value="Dthio_PD1198"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="379544at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005646">
        <property type="entry name" value="FapA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38032">
        <property type="entry name" value="PTHR38032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03961">
        <property type="entry name" value="FapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="628" mass="69189" checksum="F91BC654897014DE" modified="2010-08-10" version="1">MTDNRDGSAGSSGLELVVSEDRMSVKVKNYSPPPGTQSNLSLEDIYAELARLDVLLKPDEGLLNNILLRSWSGSPIKDMTIMTGIMPRKKGASFFEPRGNLSLPVFKGTLIGVYARAEQDQSGKNVFGRPVPPHKLDQEYYQEMVLGSGCKLDSKSGGVLAKGYGLVQMDPGKIDVKPLFRIVGEKSRIVSIIFPRDYYELEIQIEQLLKALTDMKVAESMVEQNAIETALENAHKTQSPQIAVVARGTPAKYGRNGYFELASSLQQEEVDDSDVTRRVDYRERSVYRSVAEGTVLGRIHQATPGRDGQDVFGNVIPGRDGKECPLGPGENVRLDPSTGELVAESAGLVLFQEKQVSVLDFLQVNGDVALSTGNIKLNKGSLEVMGTVRDTFSVRCPEHLIVHKNIEDAQVLAGGNIEVQGGVVMKGSGYIKVKGSLRCKFAENANIMAVGQVSFANNLTNCTVVCKDRVVSQGKGKVMGGKITAEKGMEVRELGSSYGVRTEVNIGLVPEELQSLLDQKKELKKHKDEINKKISSFDLKKSTPEQKKVIKEIMNVYSTIQERLLETERQLEEKREEFKKSTSLVLKVTDTVYPGTVITISGKTVQVQKEQKACKFYYDPVEDRVAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST87</accession>
    <name>D6ST87_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FliO/MopB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1242"/>
    <dbReference type="EnsemblBacteria" id="EFI33903">
        <property type="protein sequence ID" value="EFI33903"/>
        <property type="gene ID" value="Dthio_PD1242"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03500">
        <property type="entry name" value="FliO_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="108" mass="12068" checksum="C68F91E313F626DF" modified="2010-08-10" version="1">MDMGLAGIKMAAALFLILALIFLLYYLLKKYGHKAGLGRSGSEYLQTKAVMSLGPRKNIVVVRFLNKYLVLGVTDTQINLLKEMDADHEQEQDFSKVLNQKSSDLDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST94</accession>
    <name>D6ST94_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MotA/TolQ/ExbB proton channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD1249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871259.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1249"/>
    <dbReference type="EnsemblBacteria" id="EFI33910">
        <property type="protein sequence ID" value="EFI33910"/>
        <property type="gene ID" value="Dthio_PD1249"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="897037at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="10">
        <location>
            <begin position="100"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="253" mass="27297" checksum="DF4355B54E4F82B9" modified="2010-08-10" version="1">MDISTVLGIVIAFGLFATSITLGGSPAVFINFPAALIVLGGTIGATMVNYPLGHVLGLVGVIKHAFMKKVEDPASITEQFIQYANKARREGILSLEPVIKEVDDPYLKKGLQLTVDGMEPQTIQEIMETEISHIEDRHQTGADILGAMGAFAPAMGMIGTIIGLVLMLQDLDDPAAIGPAMAIALITTFYGVILANVLFVPMSGKLKTRSKEEILVKEMMLEGILCISKGENPRIIEEKFNSYLPPKIRRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6STB6</accession>
    <name>D6STB6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871281.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1271"/>
    <dbReference type="EnsemblBacteria" id="EFI33932">
        <property type="protein sequence ID" value="EFI33932"/>
        <property type="gene ID" value="Dthio_PD1271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933588at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022148">
        <property type="entry name" value="CopG_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12441">
        <property type="entry name" value="CopG_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11374" checksum="3060DC9028E20F39" modified="2010-08-10" version="1">MKYELTPEEQEMENSADQLRSVSGEKRQKVEDMLGRARKNEVISLRISEADLEMIRNQAAAQGLPYQTFINSILHKYVTGQLYDRQEVRKLLAEMRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6STF4</accession>
    <name>D6STF4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871319.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1309"/>
    <dbReference type="EnsemblBacteria" id="EFI33970">
        <property type="protein sequence ID" value="EFI33970"/>
        <property type="gene ID" value="Dthio_PD1309"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="246" mass="28742" checksum="B3888887D959C0F4" modified="2010-08-10" version="1">MFNPEKADNYDRWFTTPEGRFALEQERRLIQHLVSGWPRRRQSLLEIGCGTGIFLDMFWEYGFDIYGIDSSPDMLRKARDKLGCRADLHLGSAESLPFDDNEFDFAAMITLLEFCRDQGQVLAEAGRVARKGLLICFLNKNSLYHISHKLLRLWRRDKLLVRARWHSYREVRSLVQENLGNKKTYARSVLLGTRILWRDRHVFKTLNRMLWPPVFGAFTGMRVDLIDREPIKTPLLAPVKSEIKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6STU4</accession>
    <name>D6STU4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871459.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1451"/>
    <dbReference type="EnsemblBacteria" id="EFI34110">
        <property type="protein sequence ID" value="EFI34110"/>
        <property type="gene ID" value="Dthio_PD1451"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50332PR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2092422at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024399">
        <property type="entry name" value="DUF2628"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10947">
        <property type="entry name" value="DUF2628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="18908" checksum="96474BC364C09D9E" modified="2010-08-10" version="1">MRTFKIFKHPTQGYEAVKVGFSWPAFFFDMIWMLVKKLWIVAGIWFCLYIAFAIIDSVTQGPFGLFVLIVIWLSMWLIPGFKGNEWRESNLSGRGYEHIDTVQAGNPDSAIAQVTKKQEQSSEKGQQAKNAASKAEPKPEPFAGFQDIPDPSRNDQKPKLQLPKGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6STX6</accession>
    <name>D6STX6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871491.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1484"/>
    <dbReference type="EnsemblBacteria" id="EFI34142">
        <property type="protein sequence ID" value="EFI34142"/>
        <property type="gene ID" value="Dthio_PD1484"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="11720" checksum="D2095657170C222C" modified="2010-08-10" version="1">MRVEYHPAIEQEIQEIVDYYNKVVDGLGTEFLKEFDKQVAKIVDMPYRWNAVEKGIRRSLMRRFPYVIYFRVVSKDLLRITVVKHQRRHPRLGVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU40</accession>
    <name>D6SU40_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871516.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32820">
        <property type="protein sequence ID" value="EFI32820"/>
        <property type="gene ID" value="Dthio_PD0126"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031KXS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1981116at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="162" mass="18527" checksum="3CEB51BDA3CC47F0" modified="2010-08-10" version="1">MTQPASVIDLYDSLLAAEDERARARIIAGAFERLEDRYPELKDLATASGVRESELRLQKEIEQLRLRIEEVRSDLTREIEQVRADLLKEIEKTNLRIEEVRTELIREIAQVRADLSKDIERLRAETSKEIAAGNQKILRWTTGLLFAQLVAIIAVIFGVGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU52</accession>
    <name>D6SU52_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871528.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0139"/>
    <dbReference type="EnsemblBacteria" id="EFI32832">
        <property type="protein sequence ID" value="EFI32832"/>
        <property type="gene ID" value="Dthio_PD0139"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1709087at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="448"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1209" mass="140304" checksum="E9B25F0FE79EEE19" modified="2010-08-10" version="1">MSTNHTPATTWQNHLARLPYARDLMPTWQYTFVDPDYEQALNLYLSSRDETLPLDQRYEMLLQSKDLLYSLQQDKKYDISDSMLLVRVLTDLGERSQAALSAKKILERLRQEASIQLQEPFLPPLDSLEQLSMHQAPGTWLQSAVAEALARLEHPTGYHQDIHSDSLQDQVNNLQSYTLEMQRRIALSAQRAGHDMSIAPDSPLVSEGHLNHSIWKKLSGNQSLVSSPTNFISLLDYQGKTGQSLAYDTRMLARSREFKEKGRLKEASKQCFKVIKNDPTNKEAHNEFAVISSKMGDHENAYKFAGFAAADSSNPKYFRTLAAAARKLGQKDEEKMNFMKAETLEQFKAAAQEEVNKAKQIKNPDHGMDLTQIISQCERGMQKPGWDVLAFYTLSHALMASGQTKKDDRLQPLDTALKNKEWLHKRPLYHYWFDRVEFVNNQDKPEISIVMISYRPHEHTPVCLQKLREQTGDRAEIIFVNNGCPDKDFQNVHPYINTYVRLKGNAGASLPRNMGAVFADAPILLFIEDDGIAHEDLVKSHLEIYNNYKAVTVRGTYQTIQGPTPGYYYLGDKVMPSMSNLEGNSSLLTDPFFKIDGWSDYMFYGSEGRELGLRLLKAGYSYDLHLYTPKAILYHDWQRENEHMSTRKMKFFASWSLLHAMHPDEFSNFQDNWTRIMLGMIKVKPVSVCKTSAFDNKPDIEKVLEQTVKSMQKKNWAEAAQHLLSLDNNENSNVNPEENYSAKNPEYLQQGQKAWKQTQNKNQEKIISSQENGQFDHIEVKQTDFNNPLITKKTYNNIIYNNGEIDFNALNINHNIALKQLQKKSSIKVAFLLQMESMWKCDGIYKLMEKDSYFESFIFVCPYFNSSKRTQKERFYDIINNMNKTYEALKKKNFAVINSFNTKENKWIDLKKDIDPDIIFFNRPWESTNKEYTIHNFTDKLTCYVPYNFVSIDNEEQYDQATHNLTWRFFLETQAHQEIIKNNSKANGANTIVSGYPPLDVFFDKSYSPSNPWKMRKDNVKKIIFALHLTTDPEYFFEISDYIFKLARKYNNDIQIAFKPHPILKIRLIKNAPNEENKILKYFKKFESFTNTQVLEGEYKDLFLTSDGLIHNCGSFITEYACTGKPALYLKKDSYILKHKLNEVTEKIMQTCFLANNHYEIDNFINNVIINCNDNLEQKRLEVINKYLIPPNNRTASENIYWHLKNSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU69</accession>
    <name>D6SU69_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0156"/>
    <dbReference type="EnsemblBacteria" id="EFI32849">
        <property type="protein sequence ID" value="EFI32849"/>
        <property type="gene ID" value="Dthio_PD0156"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="121"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="431" mass="47718" checksum="E5A8132ABC80CB39" modified="2010-08-10" version="1">MKNKPRSYTVEMTKKNAIVLGGTVPHKFLIENLKARGYRTLLIDYYVNPPAASVCDKHIQESTLNQDAVLKIAEQENTSLVISGCVDQANVTACYVAEKLGLPAPYDYKTALRVTDKTLMKEGLVRAGVATSEYKYVSSSEVNSFQCNDYPKVVKPCDCNGSKGVRKVRNADELRLALVEACNFSRTGRAIVENFNEGQEVNGYFFISEVEVYDLYIKGKKLPETDGHTSLQSFLTLGPEQINEKAKENFIQAVSKIAQEFSLRNTPILVQANINGDSVKIIEFAPRVGGGLSSREIALLTGFDIIDSVVSSYLGEPVDLSNIRKPDSMSAVVHLYGTGGTLKRVEGMEELIAEGIVEEFHMHKTPGMEMSCEDLASRNRVMGAIIRGRSLLDINARVRRMIAVLRFFSTDNTECLNRSLFTSNGNAFYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUD5</accession>
    <name>D6SUD5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase CocE/NonD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0229"/>
    <dbReference type="EnsemblBacteria" id="EFI32915">
        <property type="protein sequence ID" value="EFI32915"/>
        <property type="gene ID" value="Dthio_PD0229"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="287"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="668" mass="75439" checksum="AF60BD9A3FF43D44" modified="2010-08-10" version="1">MNKTSKFHVIENQWISMSDGCRIAAKIWLPESAGKNPVPAILEYIPYRKRDIKARRDSQIHGFFAGHGYACIRADLRGSGDSEGVLRDEYLKQELDDGLEILSWIASQPWCNGRIGMMGISWGGFNALQIAAMQPPQLKAVISVCSSDDRYADDIHYMGGCLLTDQLSWASTMFAYNSCPPDPQIAGENWKDRWMERLEGSGLWLKNWLGHQKKDSYWKHASICQDYSSIKIPVFAVSGWADGYSNPVFRLLENLSSPVKGLVGPWGHKYPHMVELGPEIDFPGECLRWWDKWLKGVETSIMDEPPLRVWMQDTVSPLVSERPGRWVAEEKWPSPDIENLELCITSYGLETQPGMNNRDRCMEIQSPLSVGLFGGKWCSYSESTDLPWDQREEDGGALVFETPPLEKRTEILGRPVALLELSSNKPQAMVAVRLSDIGNDGRGTRVTFGLLNLTHRKSHENPEELVPDQRYQVQVPMNFIAQSFPAGHRIRLSVSTSYWPVAWPSPEPVKIALYPGSSRLVLPARKPSKLDQTLVPFDPPPALEGIKTTLLVPAKREWTVTHNLADNTVKVNVINNDPKILLEPINLAIQKDVHEAFSYSSNNYDTVRGEVVSRRSFQRDGLEMSTITRTVLTSTRTHFKITATLDAFEGDARIFSKSWDEDIPRELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUI2</accession>
    <name>D6SUI2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="15" type="ORF">Dthio_PD0276</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0276"/>
    <dbReference type="EnsemblBacteria" id="EFI32962">
        <property type="protein sequence ID" value="EFI32962"/>
        <property type="gene ID" value="Dthio_PD0276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="110"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="308"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI32962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="453" mass="49889" checksum="1353E1E81A6F5729" modified="2010-08-10" version="1">MHNYINRIHMVGIGGSGMSGIAEVLLNLGYQVSGSDLSRGPTVKILQEQGAKVFQGHHQDNVGPAQVVVKSTAVREDNPEILQARSAGIPVIPRAEMLAELMRLKTGVAVAGTHGKTTTTSFLGTIFKEAGLDPTVIIGGRLNKYGSNALPGTGEYLIAEADESDGSFLTLLPIINIVTNIGADHLDYYRDLDEIRESFVRFMNNVPFYGLNVVCGDDPEIRQVLDRVKRPVLTYGFQEQSRLRAEILSTSPGSQFNVFHDQNFWGRVKLNHPGRHNVLNCLAAIGVAIQAGIDKQDILRSLADFGGVGRRFERKGIKDDVIVVDDYGHHPTEIAATLETARQCHPDRRLVVLFQPHRFTRTRDFFGEFCRVLAGADLLLLTEIYPASEDPIPGVNGWSLAQGVMQVARTPVRFYQSLDEAGRDLDSVLKQGDLFMTLGAGNVWQVGERFIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV53</accession>
    <name>D6SV53_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871891.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0111"/>
    <dbReference type="EnsemblBacteria" id="EFI32809">
        <property type="protein sequence ID" value="EFI32809"/>
        <property type="gene ID" value="Dthio_PD0111"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925819at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="7990" checksum="6C163C916B314AB0" modified="2010-08-10" version="1">MKIEYDSKHDLMNIEFLPGEPIVDSLEVNGVVIDYGKDGKIVSIEILDASERTQKDPLGKLDFSVIRDAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV57</accession>
    <name>D6SV57_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional modulator of MazE/toxin, MazF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0115"/>
    <dbReference type="EnsemblBacteria" id="EFI32813">
        <property type="protein sequence ID" value="EFI32813"/>
        <property type="gene ID" value="Dthio_PD0115"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12606" checksum="CFB2D8A70E9B224F" modified="2010-08-10" version="1">MYQPGEVLLVPFPFSSMQASKKRPVLALTPPDTFEDMVCLAITSSPPHHAAFPLDNECFVEGVLPKPSWVRLDKVYTLNAGLFVGRFGALHSEVYERVKKHFCEHFGCQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJQ6</accession>
    <name>D6SJQ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869234.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3561"/>
    <dbReference type="EnsemblBacteria" id="EFI36109">
        <property type="protein sequence ID" value="EFI36109"/>
        <property type="gene ID" value="Dthio_PD3561"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1177" mass="134574" checksum="BF3C2FA8E7B98E3A" modified="2010-08-10" version="1">MHPLEKALRSRLERTIERARQEAEAGAVSALEQLGVQEAAPYKHLSKEDRVLRRKLRAHARHLGNGRNAKGEQEIDRLIEEVAYEHWHRMLFARYLAENNLLIYPDPVEPVSITLEECQDLAADEGATNGWELASRYAARMLPQIFRPDSPVFELTLPPENQQRLERLVEDLPREVFTASDSLGWVYQFWQSRKKEEVNASEVKIGAKELPAVTQLFTEPYMVAFLLDNSLGAWWVKMCSEGSDQPAVEARNMLQNAQSEDELRVFFSRPGFTLSYLRFVKDDESSWTPAGGTFDNWPDTLKGFKTLDPCCGSGHFLIAQFLMLVPMRMELEGLSAREAVDKVLAENIHGLEIDQRCVQLAAFSLALAAWTYPGAGGYRPLPELNLACSGLAINARKEEWLNLANGDVKLRYTLDQMYDMFKNAPVLGSLLNPTRIAEQSYWTRENYQRALELVQKIMSREKGDYEKFEMGVVAQGIAKATTLLAEKYHFVVTNVPYLARGKQDEALKEFCQEYYKEAKNDLATVFLDRCLEFCINNNLVNQGQDRRQGVSSGNVSAVFPQNWLFLTSYKKFREKLLKQDVWQLIARLGPGAFETISGEVVKAILLSISRSLKIEKPSTLMLKKDMLQDAHSNMIRGLDVSDFHPAQEKAKQIYEMDINSVEQVKQLDNPDATIKLGNRSRFGIVRDFANCFQGLTTGDDLRLKRLFWEFIQNSDNYTYWQLLQAPSHGRSLYGGRHNLVDVRITTGELKTGALRGKDAWGKWGIAIDRVGSLSPAIYCGDYFHSLVPVIIPKFKVNLSFFLSFAKSSTLKKVAEETNQALSVDNGYFEKFEFDLNHWSKVAQEEYPHGLPQPYSDDPTQWIFHGHPCGSVIWDEDKKWTAHGPLRIEANVLHVAVARLLGYRWPAELDPEMELADEQRWWVQKAGELLPLADEDGIVCIPPVRGEAAAADRLFEILVRSYGSEWSNNILNQLLTEAGNAGKTLESWLRDKFFAQHCRLFHHRPFIWHIWDGLRDGFSALVNYHRLDFKNLETLTYTYLGDWIARQKQAVSEGVDAAEEKLAAAESLKKKLELILEGENPYDIFVRWKPIEKQPIGWNPDLNDGVRLNIRPFMTVGDVSKKGAGILRDKPNIKWNKDRGKDVQSAPWYHLFKGERINDHHLNLQEKFKSRGNNNEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJS5</accession>
    <name>D6SJS5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869253.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3581"/>
    <dbReference type="EnsemblBacteria" id="EFI36128">
        <property type="protein sequence ID" value="EFI36128"/>
        <property type="gene ID" value="Dthio_PD3581"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="100290at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="772" mass="87754" checksum="D9168B32655F67D4" modified="2010-08-10" version="1">MEWLRALYASRNDSEKTKEALILRWLPWKYFVRRAARSYGIIDPIRLMARMRRFSQPSEVNEPIELLRAGIIFHARGLINTRAIQHNLDWVWPFWVQKQFNPDDSSFIPRAFSITHVNLTHRNWTAVGHPDLPLYPIVDPRGLVTPHIDGWSLDFWIVDKDGEHLLPSRAQQADQELRLESDLEVATQVRRQGRDLRSTTRVEVEENAPRARIRINAESSDNAWLAVSIRPYNPEGVQFVEKLEFREKSCSWLINGDYTVFLERQPEKILHANYLEGDVLHGIQENDMQESYKVKCPTGMATGAALYRLQPGVEQELDISVPLGGEKAGTTGRISSSREAWKRSVQGTAALNVPDKKMQFIYDAAVRSILLLSADDVVPGPYTYKRFWFRDACLMLNAMLALGLDERIEVQMDRFPGRQKYSGYFHSQEGEWDSNGQVLWIMGRYQDFTGGRISRDWWKAMEKAVKWIDRKRMTSAKNQLHAGLLPAGFSAEHLGPNDYYYWDNFWSLAGLRVAARIAQKGGDERLAGYISRIADSYHRDIQKSIASIPERRKQGAIPASPNRRMDAGAIGSLVADYPLQLYPVGSTEILNTARFLMQNCFHRGGFFQDMIHSGINAYLTLDIAQTLLRHKEPGFRDLVEAVADMASPTGQWPEAIHPITAGGCMGDGQHGWAAAEWIMMMRNMFVREEEGGLVLFSGVFPEWITSGQEVSFGPAPTAYGTVDLALYREEGQYFASVQGTWKDGLPDITIAVPGFEEVRTTDLDRPVQLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJT3</accession>
    <name>D6SJT3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3589"/>
    <dbReference type="EnsemblBacteria" id="EFI36136">
        <property type="protein sequence ID" value="EFI36136"/>
        <property type="gene ID" value="Dthio_PD3589"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087851" evidence="1">
        <location>
            <begin position="26"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="36"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="279" mass="30513" checksum="41008B07181BA044" modified="2010-08-10" version="1">MLGQKTFLSAILLFLLAFFSPPAHSQITVTAIDVGQGDCVLIQSDTHKILIDAGWGYNDVADYLAGRDIFRIDKVVATHGHADHIGGLVGVLQRKDVDKVLYNGQTHTTNTFEKFIDAIAESEAAYHEPSRGESFELGDMTLKILHPERSAADYEGHLHDMNIVVRIEYGDFAAITSGDIEQDRELEILESGVDVSAQVLELGHHGSSTSSHPDWIEAVDPELAIWQAGEDNQYGHPHDETLSTLERLGIETIGTATHGTITITAQSDGSFEVESQRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJX5</accession>
    <name>D6SJX5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3634"/>
    <dbReference type="EnsemblBacteria" id="EFI36178">
        <property type="protein sequence ID" value="EFI36178"/>
        <property type="gene ID" value="Dthio_PD3634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="63" mass="6967" checksum="7DB1DCB1BFD976E1" modified="2010-08-10" version="1">MQISGQGRKIDTECPHCGAEHSVRVETSELSWFIKIEVLYGGMVCSPCFDDGARAYHLATVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJZ5</accession>
    <name>D6SJZ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869320.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3654"/>
    <dbReference type="EnsemblBacteria" id="EFI36198">
        <property type="protein sequence ID" value="EFI36198"/>
        <property type="gene ID" value="Dthio_PD3654"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10000" checksum="5D196510A6FC1D71" modified="2010-08-10" version="1">MKNNISVAKAKATFSECIRTVEAGNSVLITRHGKPIAALVSPNDLEQLERLRKAGPECGLASIVGGWENSEELASILDASPRHGQRNTPDPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJZ9</accession>
    <name>D6SJZ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Biosynthetic peptidoglycan transglycosylase</fullName>
            <ecNumber evidence="11">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glycan polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Peptidoglycan glycosyltransferase MtgA</fullName>
            <shortName evidence="11">PGT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mtgA</name>
        <name evidence="13" type="ORF">Dthio_PD3659</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869324.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3659"/>
    <dbReference type="EnsemblBacteria" id="EFI36202">
        <property type="protein sequence ID" value="EFI36202"/>
        <property type="gene ID" value="Dthio_PD3659"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1793788at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009274">
        <property type="term" value="C:peptidoglycan-based cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00766">
        <property type="entry name" value="PGT_MtgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011812">
        <property type="entry name" value="Pep_trsgly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30400">
        <property type="entry name" value="PTHR30400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02070">
        <property type="entry name" value="mono_pep_trsgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="12">
        <location>
            <begin position="73"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI36202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="247" mass="28612" checksum="B5C22A31D5EA8449" modified="2010-08-10" version="1">MSRRKSSRTAGKRRFRLVSYILRVTLFAAFCFVLCSIILVAALKHINPPTSMFMVKRQLEGLVHEDRSWKIDYQWVDWDNISPHMALSVVASEDQKFLNHWGFDFQSIREAIEERITQGRVRGASTITQQTAKNLFLWEGRSYLRKGVEAWFTVLIETFWSKQRILEVYLNVAEFGDGIYGVYSASMHFFQNSPSNLTRREAALMASVLPNPKIYAVSAPSTYVQQRSSEIMLQMNNLGDFHLKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK35</accession>
    <name>D6SK35_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869360.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3695"/>
    <dbReference type="EnsemblBacteria" id="EFI36238">
        <property type="protein sequence ID" value="EFI36238"/>
        <property type="gene ID" value="Dthio_PD3695"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="130" mass="14901" checksum="25C4F2FDBC285212" modified="2010-08-10" version="1">MKYLLDTNTIIALFKGNKLFVDRLRSHHVRDFGISSIVVHELLYGAYKSQRQSENLERVAKLQFEVVNFTLNDARWAGSLRAQLAKNGLLIGPYDILIAGQAVSRNLTLLSNNIREFQRIEELKIEGWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK97</accession>
    <name>D6SK97_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ORF">Dthio_PD3763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869419.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3763"/>
    <dbReference type="EnsemblBacteria" id="EFI36300">
        <property type="protein sequence ID" value="EFI36300"/>
        <property type="gene ID" value="Dthio_PD3763"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0163">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1384786at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="185" mass="20020" checksum="CEF3E4516DECC8BD" modified="2010-08-10" version="1">MNKIVMAITGASGMPYALTLVQELISLDIELHLVVSSAAYKVLQLESPGYEATLSLVENIYRQDDLGAPMASGSFQHGGMVVCPCSMASLAAIAQGLGSNLIHRAADVTLKENRRLVLVPRETPLNRVHLQNMLAARDAGAVILPPCPGFYNKPQEMQDLIRHIAARIMDSLGIENSVSRRWEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKB7</accession>
    <name>D6SKB7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3785"/>
    <dbReference type="EnsemblBacteria" id="EFI36320">
        <property type="protein sequence ID" value="EFI36320"/>
        <property type="gene ID" value="Dthio_PD3785"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="146"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="404"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="478"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="709"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="782"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="835"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="915"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1207" mass="136501" checksum="2DB75ACC6F1BA7D1" modified="2010-08-10" version="1">MSQKTSPPTDQGSIEPPVFENPQGILMNAPVCIFTTTPDGRYLSVNNTLARMHGYDSPRQLMDSVTDIATQIYADPADRDKLKSMLEQYGQVTNFECRLRHRSGRIFWVSENISVIKDKDGNITAYQGFNQAITERKQTELALHKSEERFSLAMQATRDGLWDWDVTTGEVYFSPGYARMLGYDSTEVPPHVQTWLDLIHPEDKEKAYQANLDCINNLVDSFEVEFRMQAKNRDWVWILGRGSAVRRDESGKALRMIGTHTDITNRKQAEEARIASEQKFKNLIEKCPASVMLLDHQGRVEFVNDWHIEKFANNKLGKEYFLGRSIHELPGLVNAGVDTEISRVFQGDDVELENVYFPEFAVGGSGWVNIRAVPVYQGGRVAGGVLLRENITARKKMETALQQSQQKFRSLVENTQDVIYSHTPEGHFTYLSPQVSDLLGYEVQELLGKNFQDLVHPQDLPVVQRGLDNALKTDQNHGEVEYRLLHKDGHYRWFHVRVSFQRNSEGEIESVLGVARDITERKQAEELLRESEERTRHLNAVLKAYNQVNEVIFNAGDITPLLQEVCQALISTRGYYNAWIILLDKNKNVTHFGQAGLDDEFQELIDGFQYGKKPACALNVSTSPGLQVVMDPGTDCEGCPLAEQYSDRSGFSARLEVEGFVLGLITVSIPANLAGDLEEQDLFNSLAWTIAQGIQRIRLEKIRRSQRERLKNYERIISRINDGMAIVAPDYRYIIVNDAYQREFGKPREEIEGHTVEELVGKEVFYSKIKPRLDTAFAGEEVVSEDSFPGLDGVLKYKVMNYYPFYEKDGSVAGVVATGKDFTEQKKAEDALRESEELLRTVNETVGEGIVLKDASDRFVHWNKTASDIFGLDIEHARGQTPEVFDIKFIHEDGTEYAGDDFPSQHTLRTGEPCNNVIMGIKRNNQSTTWLKINTRPIFTPGEAKPYLVVVSFSDITERKHAEEKLKSMNQQLQKSNAEKDELFSFVAHDLKAPIAGFLSLTEVLNKYFDDFSMDELREMLSEMHKSSEGLHALLEDLLQWARVKKGMLVYTPESVCLNDLVTAGISLARSVADQKDINLWNNVPRGMNLYADQKMIYSVIRNLLFNALKFTYQGGNVSIHAHKQGSMVKIMIHDDGMGMDQDTAARVFAIDKRKSVKGTDGEKGTGLGLALCKEFVEQHGGRIWIDSEPGQGTTVYFTVPGNGEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKF6</accession>
    <name>D6SKF6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3827"/>
    <dbReference type="EnsemblBacteria" id="EFI36359">
        <property type="protein sequence ID" value="EFI36359"/>
        <property type="gene ID" value="Dthio_PD3827"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="137"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="473" mass="54176" checksum="0F89C82B7C9FBD05" modified="2010-08-10" version="1">MKKSPRIFIFSRDRTFYREAVREMRSLGSCHAADDFQDLRIDLLEKCEAIIMDLHLSQENQLNFFKKNMEQLHRPAVIVVTDEHDSDLIETAITLGAWDYFQKPVFWKRLRESVGRALEASSTLSAINYGDFKRCGIIGSSRSINSCLTTLASFARSNSNVLIYGETGTGKELFSRAVHLNSPRSHKPFIIIDCAALPENLVESTLFGHEKGAFTTADKKHTGLIRQAHGGSLFLDEIGELSLNTQKLFLRVLQERRFRPVGSATEIFCDFRLVAATNKDLDRMCAEGTFRRDLLFRLHSFALTLPPLNSREEDVLELMYYFLDRICKKHGLENKQPSPEVIDAFAGYSWPGNVRELINTLEHMAITARHEPVIQPEHLPLPLKVFCKQQVMEKDMMQACTESQEPARDEEFPKIKEYREQAIARIEKKYLEELLQASGKDMPTACRLSGLSRPRLYAMLKKYGLSPVKHRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKJ6</accession>
    <name>D6SKJ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868341.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35207">
        <property type="protein sequence ID" value="EFI35207"/>
        <property type="gene ID" value="Dthio_PD2616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="25546" checksum="DB85B58C5F72A695" modified="2010-08-10" version="1">MWIAVPVVAAALAGLLVFAAVHSNRRLYETTSHIYQQLAGPANGRVTQMPRVLGKMTALELPVHDGQAFLHILDKEVSFYVHSPELKNCMPLWINDNMRKTLGSCKSGDPDFDRVFSVYKGPDDREKLLEKFDRDCRLAMLQLKEQALKHARNIWVELIHVRPRDDIFIIRINNFLLTRRGMTRYPEDISVYRDLLDRSMQVYLAFRRSACTSGDSQGQQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKR8</accession>
    <name>D6SKR8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868411.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2692"/>
    <dbReference type="EnsemblBacteria" id="EFI35279">
        <property type="protein sequence ID" value="EFI35279"/>
        <property type="gene ID" value="Dthio_PD2692"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033E9F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931387at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="138" mass="15677" checksum="E9ACCFAA891F48A7" modified="2010-08-10" version="1">MKRVFLDANVLFTAAHNPSGKAALLMELAERVYWHLMTSELACEEARRNICIKFPDCLPRIEELCRSIHIVSHVHEMDCPLELPDKDKPIFMAAVQGRASHLLTGDLAHFGPFMNKASETQYIVIQTVSDFFLSFLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKV1</accession>
    <name>D6SKV1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35312">
        <property type="protein sequence ID" value="EFI35312"/>
        <property type="gene ID" value="Dthio_PD2727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="551" mass="64686" checksum="6DA63C163B99FE95" modified="2010-08-10" version="1">MCLGFSLFAVIKYYKKFIFHSASPVKFIVLLRLRFFAERAKCAELWGKSTEIWQEILHICSGKSPVEAYLELGRAGRLYGLLDIAEESVKSGLNMHPHNIQLKKEYAEIATHRENWPEAIKRWQEVVEKNDEDLSPSISLIQLSKAILKYKLYKNNKIEAQLWNDFKAIEIQIHKIIAKKSHDPVLMLELTEWALINNERLQAEHQLSMFMNVCRTTTIASSLIIKFINLCNNNNLLKNKDKMYCAINNYSDIKISTVNVLSYISNKKIKYNEIKTLNCDKGLSNHGVWFHEARSYKIIEKVTSVLNEKIVLRHIYKNNISTEDIVPRLYGYIEHEYISIVYMEYLKNIGNVPKFNKHNAVKISDAIIMFEDYLSSIPEICSKKFNINNIVYRIKLLFDKVSCFESKDILKKLCKFVEYESFILTNYPYVACHGDLTFDNMYFKMYENGNISKIKILDFGLCMKYPIGYDFHHFIRESILNKEFLPFLHQMIKNYALAKNIDEQKLYYNATFFAAIRALNVVGRSNNKDFLFKEIDNLIKITRSFFKIRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKX4</accession>
    <name>D6SKX4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868467.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2750"/>
    <dbReference type="EnsemblBacteria" id="EFI35335">
        <property type="protein sequence ID" value="EFI35335"/>
        <property type="gene ID" value="Dthio_PD2750"/>
    </dbReference>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020942">
        <property type="entry name" value="Cyt_c_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02085">
        <property type="entry name" value="Cytochrom_CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrom_CIII" evidence="4">
        <location>
            <begin position="35"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="134" mass="15118" checksum="CCB34BED08AAC44F" modified="2010-08-10" version="1">MSKKIIYLLGTIAVAVFFLAPALYSYTGMTHIYEDAFPTKERPASVFPHDEHTDVYAQEYDLDELKDCYHCHHFDGPDQEHTDDSVGIPCSDCHPVETDDPDTTPLMQAYHIQCKSCHQDEKAGPVACGECHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKZ4</accession>
    <name>D6SKZ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2770"/>
    <dbReference type="EnsemblBacteria" id="EFI35355">
        <property type="protein sequence ID" value="EFI35355"/>
        <property type="gene ID" value="Dthio_PD2770"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="28539" checksum="C84D91F0928FEC96" modified="2010-08-10" version="1">MHMVNELVLVGSKGQMGTLIKNKLSAGGVNVLPLDRPFPEEELPDILGRADMLLLAVPVAGMDEVLELMSPYFSSALIVADISSVKTLPVNKMQHFHQGPVMGTHPLFGPSPSEDDELKVALCPGHNLQDHHVQAVSEVFDRGGMLTFISSCREHDQAMACIQGLNFVTTISYFASLPQDIDLDTFATPSFRRRATAARKMLNEDAVLFSSLAEDNPYTGQMIRRFKSFLNLSAAGEFELLTDKALWWWRNFSDRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL56</accession>
    <name>D6SL56_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35417">
        <property type="protein sequence ID" value="EFI35417"/>
        <property type="gene ID" value="Dthio_PD2835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="42" mass="4731" checksum="A59F1402B8477591" modified="2010-08-10" version="1">MPQPDFWAGLPNVLIKAKDFTVDRAASFYMEVSIGIIFTLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLB1</accession>
    <name>D6SLB1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868604.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2892"/>
    <dbReference type="EnsemblBacteria" id="EFI35472">
        <property type="protein sequence ID" value="EFI35472"/>
        <property type="gene ID" value="Dthio_PD2892"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YQJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1948244at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="81" mass="9413" checksum="A68D1C46C6C0A6FB" modified="2010-08-10" version="1">MAPVVLRFEGLKFFFYSNEGIPPEPAHIHVRQGGSEAKFWLSPHIQLARNHGFNAQELSKIARLTAENNEYLLEVWHEYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLD1</accession>
    <name>D6SLD1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868624.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2915"/>
    <dbReference type="EnsemblBacteria" id="EFI35492">
        <property type="protein sequence ID" value="EFI35492"/>
        <property type="gene ID" value="Dthio_PD2915"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="399" mass="44006" checksum="0EDBE9C97894F7E9" modified="2010-08-10" version="1">MLTFKLGPCNDDIEGSRVIRAVLRHALCKKVFMLIDTTLREGDQRYGLYLSLEQKKVIVDGLHRLGLDELETGSVGRDEELETLIKYARQHHGSTKISLWSPCRIQELEYADSLDPDIISAALPVSDLHIEKRLGLDRCGALRLLERTLAGTDKLKAKLSLGLEDFSRADREFALRAALMARDLGVWRVRLSDTLGVMEPGELMEAVRPFREKLDISLAFHGHNDFGMATANALTALSCGVDYVDVSLLGIGERAGIARLEEVLTFLVYNKGHAGYDVQSLPELSTCVAGLAGVHINPDRAVLGRQLFHCESGLHADALYKSFDLFEPFEPHKMGMQRRISLGRKSGAGAVRGKLMEMGVNPDFVDLEGLVRDVRRAASIKGSPLDDEQVVSMLQGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLJ9</accession>
    <name>D6SLJ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868692.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2986"/>
    <dbReference type="EnsemblBacteria" id="EFI35560">
        <property type="protein sequence ID" value="EFI35560"/>
        <property type="gene ID" value="Dthio_PD2986"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="506" mass="57863" checksum="0D6ED9848EBB5A41" modified="2010-08-10" version="1">MKNHQKIDEMIDLLPENLAQAQGMLKDKIMPLIAQQERHMQEHYLKKIKKRTKSTKKAVNELYHDSVTLLEQEEEDELLVVDPEIAAASQELARDPALFRKRIKAVEELGLVGETRNIGMALVTLDSRLNPVKETLFSMIAGHQGCGKSEIVFKALELYPKSTYFLITSASSKAFAGMGDFLQYKALIVTEAHILERESEVTQAIRTLQSEGFITYTKQERVAGKLTTVTYTVKGPMSLITTTVKDKLEKQIADRMFALHPNTSEEQTQEILRQKVLAAAGDKQDLDTQAWKLFHEMLESYDVKIPYAEQIFNCMNTDSMPTTARRAFSRILHAIKTVTIVHQEQRQLCDDKMLVAEIGDYAIVYQLFKNTFLEDVGEFERLTDEILIILEQQGPRTPKELIQKMGGKKSTLSDWIKRNIESGYIYWVDEQEQRFSNDLLLKKAQKRGKAYLKVEQGPALPTPYELTLDSRWDVGGEFYKFYDLELEDTTARPEPAHAIDPFRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLQ4</accession>
    <name>D6SLQ4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868744.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3044"/>
    <dbReference type="EnsemblBacteria" id="EFI35615">
        <property type="protein sequence ID" value="EFI35615"/>
        <property type="gene ID" value="Dthio_PD3044"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="279" mass="31772" checksum="012DB5F36F02913E" modified="2010-08-10" version="1">MKITPDELKVLAQYIYNVSGIHLDQSKAYLLESRLKPLIAEHNLSSYTQLYHKAKADASKTLEKAIIDAVTTKETLFFRDSGPFEVFKHKILPDIIDARSKRLHKSMPVKLRIWSAACSTGQEVYSIAIAIKETIPDLNKYQVSILGTDISDQAIAQASYGKYNKFEIERGLSKDKLQKYFSPTEDGNWRIKDEVRMLANFRKVNLMQAFSGLGRFDVIFCRNVAIYFKPDDKKKLFERLAGVLQPDGALIIGSTESLSGVTRSFVPKRYLRSIYYQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLR3</accession>
    <name>D6SLR3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868753.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3053"/>
    <dbReference type="EnsemblBacteria" id="EFI35624">
        <property type="protein sequence ID" value="EFI35624"/>
        <property type="gene ID" value="Dthio_PD3053"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2032133at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021320">
        <property type="entry name" value="DUF2905"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36443">
        <property type="entry name" value="PTHR36443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11146">
        <property type="entry name" value="DUF2905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8396" checksum="695BCCDE05BF8F21" modified="2010-08-10" version="1">MQEWPDPGKILIIIGLVLAAVGLLVLLRDKLPFTPGRLPGDILIKRENFTFYFPLGTCILISAVLTLIFFLWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLZ0</accession>
    <name>D6SLZ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868830.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3130"/>
    <dbReference type="EnsemblBacteria" id="EFI35701">
        <property type="protein sequence ID" value="EFI35701"/>
        <property type="gene ID" value="Dthio_PD3130"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="4">
        <location>
            <begin position="200"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="410" mass="45317" checksum="D4FAF8F2A2921CB5" modified="2010-08-10" version="1">MQQIIQYLDKQADEVVQLQSSLVSIPALGPSNEGRGEKEKADFVHKYLRACGFEEIIEINAPDQRVECGYRPNLAAWIRGRDAGRTLWIISHLDIVPPGDLSLWKSDPYSLEVDVDTLIGRGVEDNHQSIVSSVLAARAFMEQGVKPDINLGLLFVADEETGNDYGLPYVLDNRKDLFEKDDLFLVPDFGTSDSTMMEVAEKSMLWLKVSVKGRQCHASTPEKGINSLAASAAFILQLERLHEIFPGRNDLFSPAGSTFCPTKKEANVPNINTIPGLDVFYLDCRILAEYSIQDVINEARNLGSDIEKKYGVHIDYEVVYQQQAAPHTDPASEVVQRLARGIEKVYQVKPEPRGVGGGTVAAFLRHRGYSAVVWATLTGTAHQPNERSSIASTLKDAQVMALMAINDETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM00</accession>
    <name>D6SM00_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapA</name>
        <name evidence="10" type="ORF">Dthio_PD3140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868840.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3140"/>
    <dbReference type="EnsemblBacteria" id="EFI35711">
        <property type="protein sequence ID" value="EFI35711"/>
        <property type="gene ID" value="Dthio_PD3140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="292" mass="32046" checksum="B60EEAEBDB4F437C" modified="2010-08-10" version="1">MQFRGAYTALVTPFKNNQLDEEAYRNLIEWQLEQGIDGVVPCGTTGESATLSHEEHKRTISVCVDQVKGRVPVIAGAGSNCTSEAVDLTRYAKEAGADAALLITPYYNKPTPDGLLAHFKTIAREVPIPFFIYNVPGRTGLNVLPDTVARIFREVPEAVGIKEATGNLTQVSSVIEECGPDFTVLSGEDSIVLPLMAVGGHGVISVSSNIVPNMMHSLCKAYMDNDQEKAKKLHLEMAPLCRAMFFETNPIPVKTSLALMKKIELELRLPLVPMQEKNQARLKEVLQNKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM01</accession>
    <name>D6SM01_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868841.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3141"/>
    <dbReference type="EnsemblBacteria" id="EFI35712">
        <property type="protein sequence ID" value="EFI35712"/>
        <property type="gene ID" value="Dthio_PD3141"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="290"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="340" mass="36065" checksum="029FCFE9F7144971" modified="2010-08-10" version="1">MNWNDITKEAKEKLKGYCRVCPVCDGRMCAGEVPGMGGMGTGEAFKVNLKALARYRLRMRAVHGVKKPDTGIRLWGRDFKTPIMAAPMTGTTYNMGGQITEQEFIDHIISGSIDSGSIGFSGDGADPAMFDSGVQAIKNNQGQGIPIIKPRAQEEIVKRIRSAEEAGAMAVGVDIDGAGLVTMALKGQAVGPKDKHEIKELVQSTDLPFVLKGIMTIDDALDALEAGVSTIVVSNHGGRVLDHTPGAAEVLPEISEMVRGRMTIIADGGVRSGSDVIKLLALGADAVLVGRPLITGAFGGGKEGVSFVLNKYTQELIQAMLLTGVPDVEKVCPRILDHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM19</accession>
    <name>D6SM19_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD3159</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868859.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3159"/>
    <dbReference type="EnsemblBacteria" id="EFI35730">
        <property type="protein sequence ID" value="EFI35730"/>
        <property type="gene ID" value="Dthio_PD3159"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1953248at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="13">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="173" mass="19360" checksum="62A575F3C3D2FFD5" modified="2010-08-10" version="1">MKYSDCSEFMQDIFISLGSNMGNPADNLERAAQLLTDLPGLSLVKKSSVYLTEPQGMKDQPWFANQVMWMRCGDSWQPLDLLAALKELEKNMGRIPGPRNGPRVIDLDILLFAGMEINEEGLILPHHGLGSRAFVLIPLLEIFPELVLPDGQVAARLLQGLEFRLEGHKIFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM98</accession>
    <name>D6SM98_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868938.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3244"/>
    <dbReference type="EnsemblBacteria" id="EFI35809">
        <property type="protein sequence ID" value="EFI35809"/>
        <property type="gene ID" value="Dthio_PD3244"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="22013" checksum="0198BFDB36AC32D0" modified="2010-08-10" version="1">MSDLVAIYGSPRRKGNTAALLSRAVQGARDSGASVQEYVLRDLKISPCLEIYKCQKDGECAIEDDFQEVRDRILQARGLILASPIFFYSVSAHTKAFMDRFQSMWVRKYWIDEEQPGKKDLKRKGLFISAGATRGARLFDGAVLSVRYFFDVLDMQLWGSLLFRGLDGANDVQNYPEYLDEAYSLGRDMYYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMC4</accession>
    <name>D6SMC4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868964.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35835">
        <property type="protein sequence ID" value="EFI35835"/>
        <property type="gene ID" value="Dthio_PD3271"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121046at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="146" mass="16521" checksum="6786BB2FF5DD8079" modified="2010-08-10" version="1">MKARPDYFGKLEELSDLLQNEQDLVVVGKYFLDNLSDDRNFISAGKLVKDKMIKQVLKEVGKQFVSPDAKITNMLITYIKEFDFYHGPLFLGGKPSSFFYYTKLQIGMAMIIQGMGNNSNTSFVRFRAAKLPGKGFAVVPHNPTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SME8</accession>
    <name>D6SME8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868988.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3298"/>
    <dbReference type="EnsemblBacteria" id="EFI35859">
        <property type="protein sequence ID" value="EFI35859"/>
        <property type="gene ID" value="Dthio_PD3298"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="732679at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="8">
        <location>
            <begin position="179"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="33125" checksum="BEE99E46187181E8" modified="2010-08-10" version="1">MSVLVFGHKNPDTDSICAAIAVADLKSKLGLDCKPVTQGELTPESKFVLDKFGLSAPETVTSVAGQKVILVDHSDLAQSPDDLKEAEILGIIDHHKLGDVTTPNPLECWIWPVGCTCTVIKAMYDFYGVELPKNIAGAMLCAILSDTVIFKSATCTEDDKKACEALAGIAGVSDITSLGMEMFKVKSAVDKDTPRDLIFRDYKDFSMGGSKVGIGQLEVVDLSIVEPVKDALYEEMKKVKEEGGRNAVYLMLTDIMKEGTELLVLADDPEPVKKAFGKPVEGTSVWLDGVMSRKKQVVPNFEKAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMG6</accession>
    <name>D6SMG6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869006.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3316"/>
    <dbReference type="EnsemblBacteria" id="EFI35877">
        <property type="protein sequence ID" value="EFI35877"/>
        <property type="gene ID" value="Dthio_PD3316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1852220at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="18007" checksum="468B5046F92B3A22" modified="2010-08-10" version="1">MKGTFLFILILCLAATIIAFKKDPQLVNDGFVQGMKMLAKILPILLVAFILAGMVEQILPKDLLADILGPESGFRGLALGTLAGAVMPGGPFILFPLMAVLLKAGAGVGPLVAFLTSWALLGFHRLLIYEAPIMGWKFALCRMAASLIFPIVIGYFADWAWKAWSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMR1</accession>
    <name>D6SMR1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ORF">Dthio_PD3414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869100.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3414"/>
    <dbReference type="EnsemblBacteria" id="EFI35972">
        <property type="protein sequence ID" value="EFI35972"/>
        <property type="gene ID" value="Dthio_PD3414"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="11820" checksum="860DAE23B32982E7" modified="2010-08-10" version="1">MFAIVESGGKQYRVREGQRLKVARMDQEPGEEVVLDSVLAVGQDDDVQFGKPYLDQARVVCDILEHDRDKKVIVFKKKRRKGYSKKQGHRQDFTAVKVKSIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMR2</accession>
    <name>D6SMR2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869101.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3415"/>
    <dbReference type="EnsemblBacteria" id="EFI35973">
        <property type="protein sequence ID" value="EFI35973"/>
        <property type="gene ID" value="Dthio_PD3415"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="201"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="262" mass="29689" checksum="85D203871404B3B7" modified="2010-08-10" version="1">MMYAFKNVLKEQLRVYGLYSFHPWKLTRVLRREFLGRRCLICGMVRDKETGPDTMCPACLEKIKIRRRGFCPGCAKIYTLEEASPYYCLDCRTRPFPWSGLGFFGPYQDRLRELILCFKFKGDLGLGRVLGGMLVQAGQYHGGVKADMVVPVPMHESKLKMRGFNQSLELARIFSASTGFQLQHRAMVKKRPTAAQSSLNRKDRMKELKGAFEAHAGVVRGQSILLVDDIYTTGSTLEECTRTLIKAGASRVQVLFLARGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMT0</accession>
    <name>D6SMT0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tripartite ATP-independent periplasmic transporter DctQ component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869119.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3433"/>
    <dbReference type="EnsemblBacteria" id="EFI35991">
        <property type="protein sequence ID" value="EFI35991"/>
        <property type="gene ID" value="Dthio_PD3433"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1947990at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="165" mass="18387" checksum="C84B932F08195677" modified="2010-08-10" version="1">MELLEKIVHNLALRISQIAQLALVLVMLVIVSNIFMRAWWKPLTGSYELVEILGAVILSMGVAYCAVNRGHVTVSLLVDSLPPKIQNIVEIITNAISLTFISLISWGLLQYASNVHRRNLSTSSLDLPLYPVYYLVACGMIMLAMIIVLELIKNTLALIRGRKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMU1</accession>
    <name>D6SMU1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869130.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3444"/>
    <dbReference type="EnsemblBacteria" id="EFI36002">
        <property type="protein sequence ID" value="EFI36002"/>
        <property type="gene ID" value="Dthio_PD3444"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1345463at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="174" mass="20101" checksum="785E4AE0C55DF5F4" modified="2010-08-10" version="1">MDLQLAQEKDAVLGKDFLTWLWFKSEEQNHVFKTREGEDFALWMGQKIVVEGGEGESLEKAVCTGMMSRLQEAKLGLGTGKKVVQARVTLEEDSNSWSMQLDAGMFSFNGLKPPKVDTQLQEGEDPDGAFLEKMYLLERAIYYTDEVYSMFLGKRMSSEWNQECQRIREWIYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMV3</accession>
    <name>D6SMV3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dnaK</name>
        <name evidence="11" type="ORF">Dthio_PD3456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869142.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3456"/>
    <dbReference type="EnsemblBacteria" id="EFI36014">
        <property type="protein sequence ID" value="EFI36014"/>
        <property type="gene ID" value="Dthio_PD3456"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="591"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI36014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="640" mass="69997" checksum="2FEE7BDB5163A0AE" modified="2010-08-10" version="1">MGKIIGIDLGTTNSCVYVMEGKEAKCISNPEGGRTTPSIVAFTDKERLVGEIAKRQSVTNPEKTVYSVKRLMGRQYDDPVLKNWIERCSYKIVKGKNDDAYVQVGDNTYSPPEISAMILQKLKSDAESYLGETVSEAVITVPAYFNDSQRQATKDAGRVAGLEVKRIINEPTAASLAYGADKNVNEKIAVFDLGGGTFDISILEVGDNLVEVRSTHGDTFLGGEDFDQRIINHLVDEFKKENGIDLSQDRMALQRLREAAEKAKKELSTTMETDINLPFITADQNGPKHMNMKLTRSKLESLVEDLVQRTIGPCEKALSDADLKANDINQVLLVGGQTRMPLVQKKVSEFFGKDPNKSVNPDEVVAMGAAIQGGIFAGDVKDVLLLDVTPLSLGIETMGGVFTKLIERNTTIPTRKSQIFTTAADNQPSVSIHVLQGERPMAADNMTLGRFELTGIPPAPRGVPQIEVTFDIDANGLVNVSAKDTGTGKEQSIQITASSGLSEEEINNLVKEAESHAEEDKKKQRLIEARNHADTLIYTTEKSIRDLGENLDAELKADIENKIQELKNVMEGEDEEAIRKATEDLSQASHKLAEKLYAQKTQSGEAGQQDQGEAQTGQQGAQSAEEDVVDADYTEVNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMV7</accession>
    <name>D6SMV7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ORF">Dthio_PD3460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869146.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3460"/>
    <dbReference type="EnsemblBacteria" id="EFI36018">
        <property type="protein sequence ID" value="EFI36018"/>
        <property type="gene ID" value="Dthio_PD3460"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="292"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="344" mass="38567" checksum="63F38AA138A91B28" modified="2010-08-10" version="1">MRIAVAVSGGLDSLASLVMLREEGHDVLALHARFFPRLDEHLEKRLKGICTSLGVEMHVTLLQDEFAARVIDPFVQDYLDGLTPNPCARCNMRIKFGLLLDRALELGASALATGHYAGIKKNSSGPVLMRALDQAKDQSYFLCLVPPRRLARAKFPMYHHFKSSMQEFLQNRNITVPAREESNEICFIPGDYRDFIAGRLEKSHEPLPGPIVDSSGRTLGRHQGLWRYTPGQRRGLGIAFKHPLYVLRKDLASNTLVVGAREELGAGEFQARDVNILEEPRKWPLDLLVQTRYRQKARPAEVELWGQRMRVRYKGEPGLPVPGQVAAVYSPKGQVLAGGIIQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN49</accession>
    <name>D6SN49_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869505.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1523"/>
    <dbReference type="EnsemblBacteria" id="EFI34175">
        <property type="protein sequence ID" value="EFI34175"/>
        <property type="gene ID" value="Dthio_PD1523"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZGFC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077740at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8374" checksum="EBDD43B742EE93E2" modified="2010-08-10" version="1">MHVFADGISKVTLSNGNLRIMLTQRGADDSQVEAGTMIIPASQASNFLNGLASSLRELDEKLKAAREEEPEEIEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN90</accession>
    <name>D6SN90_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869544.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1567"/>
    <dbReference type="EnsemblBacteria" id="EFI34216">
        <property type="protein sequence ID" value="EFI34216"/>
        <property type="gene ID" value="Dthio_PD1567"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1730305at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013630">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038576">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08421">
        <property type="entry name" value="Methyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_13" evidence="1">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_14" evidence="2">
        <location>
            <begin position="245"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="407" mass="45657" checksum="BE191ED62E119048" modified="2010-08-10" version="1">MNCRHCGVSLDCVFVDLGFAPISNSYLERRDLQRPETYYPLKLFVCSRCRLVQTQDCTGSEDHFRYDYAYFSSTSSSWLRHAEEYSSMITKRLGLGKNSLVLEVASNDGYLLKNFVSAGIPCLGVEPAGRVADAAEQLCVPVLREFFGAELGLRLAEEGRQADLVIGNNVYAHAPDVNDFTAGLKAVLKPGGVITLEFPHLLNLIRFCQFDTIYHEHFSYFSLDAVKSIFYSHSLRIWDVQELSTHGGSLRVYGCHLDDPRPESASVRTLLEKEKQYGLHDMQVYKDFSSCAERIKDDLVMFLIEQKRGGRKVAAYGAAAKGSTLLNYAGIKPDLISFVCDAAPSKQGKFMPGSHIPVLSGHVLQQFRPDTLLILPWNIRDEIVSQHSYIRQWGGKFAVAVPVLEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNH2</accession>
    <name>D6SNH2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869626.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1649"/>
    <dbReference type="EnsemblBacteria" id="EFI34298">
        <property type="protein sequence ID" value="EFI34298"/>
        <property type="gene ID" value="Dthio_PD1649"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="87" mass="9708" checksum="857B9381BA4001FD" modified="2010-08-10" version="1">MRNILIGLIRVYQRILSPLFPPACRFLPSCSEYARESIVMHGPGKGTVLTFFRLLRCNPFFAAGLDPVPEKFSLKSILGATKEHGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNH7</accession>
    <name>D6SNH7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1654"/>
    <dbReference type="EnsemblBacteria" id="EFI34303">
        <property type="protein sequence ID" value="EFI34303"/>
        <property type="gene ID" value="Dthio_PD1654"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="158"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="328" mass="36330" checksum="CBD3AB499CE4E332" modified="2010-08-10" version="1">MNKLDLGIIGVGHLGSIHARLAAESEKINLVGVFDLDRERAEKAARDSSTECFRDMHALLEKVQGVSIVVPTSEHHSVALKALDYGCHLFLEKPIASSVDQARDIVQKAREKNRKIQVGHIERFNPAILAIKDHPLKPMFIEAHRLSTFNPRGCDVSVVLDLMIHDLDLILYLVKSPVTHVDACGVAVVSREEDIANVRLKFASGCVANITSSRIALSPMRRMRLFQQNQYIALDFQEKKADIFKLTDQDTIPDPGCKPAVVSRIGVGDNARDVIYEKPSPPEVNSLQMELEEFAKAVVHDLEPEVPGEQGLMALETAANILEQIARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNJ8</accession>
    <name>D6SNJ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S9 prolyl oligopeptidase active site domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869652.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1675"/>
    <dbReference type="MEROPS" id="S09.A77"/>
    <dbReference type="EnsemblBacteria" id="EFI34324">
        <property type="protein sequence ID" value="EFI34324"/>
        <property type="gene ID" value="Dthio_PD1675"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088121" evidence="2">
        <location>
            <begin position="25"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="443"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="690" mass="78143" checksum="E0BB742B85307AC4" modified="2010-08-10" version="1">MKSLTVLLWFAVFACLTIAFPVNALGESGNKLDYLEDLPPLLDRELFFDDPEMDSATISPDGEKIAFRQKFQGVMNIWVKDREDSFEEARPLTDDEHPIRMFFWSRDSENILYAQDKQGDENFNLYAVDPAGETAEDADVPESRALTDYEGVQTRVIARPEEKPEYVVVAVNNRDPALHDVYKIHVQSGERELIFKNEHNITSWKVDEYGRIRFASRETPDGGTEILKLEEGELEQVYRVDFGESARIAHLPRGYDNDRVYLVTNRGDADLTRLVLFDPQSGDKELVEKDPEGEVDFGGAIFSRVTDELLATYYDGDKERVYFHEDEFKEDYERIRAMLPEGDITFRSRTQDEDMWIISVSRDVDPGSVYLYDRDSGEVDLLYRSRPDLPTQYLASMEPIRYEARDGLEIPAYLTLPRGVEPEDLALVVMPHGGPWVRDYWGYDPQAQFLANRGYAVLQPNYRGSSGFGKEFLNAGNKEWGTGYMQHDITDGVKHLIEEGVVDSDHVGIYGASYGGFATLAGLAFTPDLYAAGASMVGPSNIITLIESVPEYWKPILKSFKLRVGDPEDPEDRQRLKEQSPLFSAENIQAPLLVAQGANDPRVPKRESDQIVAALRDQGQVVQYLVAPDEGHGFARPQNRLAFFVELERFLASFLGGRGQTDVPTEVAQRLAEIIYDLEEVEVEAPESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNN5</accession>
    <name>D6SNN5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869689.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1712"/>
    <dbReference type="EnsemblBacteria" id="EFI34361">
        <property type="protein sequence ID" value="EFI34361"/>
        <property type="gene ID" value="Dthio_PD1712"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1858718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="166" mass="18223" checksum="FA04CF3313EF62F5" modified="2010-08-10" version="1">MNDVRTIVLGIGNPLLQDDRAGLEVARRVFELGLSVDTQELYTVGFEVMDRLMSYDRAFIVDACRLGNKPGTVMEVRIEDIFSSKSLASSHAITLGATLKTAYQLFPDEMPGELRIFLIEVERIDEFTDIMSPCVDQAVQQAVDIISATISPVPVSHTGGKNLTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNR6</accession>
    <name>D6SNR6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Csy2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869718.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1745"/>
    <dbReference type="EnsemblBacteria" id="EFI34392">
        <property type="protein sequence ID" value="EFI34392"/>
        <property type="gene ID" value="Dthio_PD1745"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50323NM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="798820at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013398">
        <property type="entry name" value="CRISPR-assoc_prot_Csy2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09614">
        <property type="entry name" value="Cas_Csy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="278" mass="30926" checksum="08904A078623CE14" modified="2010-08-10" version="1">MSIYLIFNNLMVRRANMMQSPYLYAPVPVFPSVCTGHKLGCMLDCEVDGVGVVHHRAEPLIEQMAQMNQGSNRVNIVTSPIQFRGTPSGKQVNTKDPIGLPMQPTMTAHLEISLIFRVNGRVPTVEAAREAMQGLRIAGGSLNYISSRRVKLKDDLIGALAEVSNGFWISDAMHLVQQRLDEGFDPVSAIFQKADKGWYVPANLGYCAVTDFKQRQGGRTLVWEDGRVDEPEIALADNMIGLVRYDPLYGVKQELNSGGTVGMWHFDFTDDTFFVVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNW3</accession>
    <name>D6SNW3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-ACP thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-ACP thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869761.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1798"/>
    <dbReference type="EnsemblBacteria" id="EFI34439">
        <property type="protein sequence ID" value="EFI34439"/>
        <property type="gene ID" value="Dthio_PD1798"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:acyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045023">
        <property type="entry name" value="FATA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727">
        <property type="entry name" value="PTHR31727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="29530" checksum="B4193138E48B03F5" modified="2010-08-10" version="1">MQHPTHTETGTIRVSQVDRSRRIKLTSLLDWMQDSAYTHSNLLEIFSTDRLLARNMSWVLMRKLIRIESFPCLGQTVRLTTFPSALNRYFAFRDFKLQDEKGTPLVLATTSWAVFDLEKRRIIRTPAEFIRDFSAPGPPCLEFSQARISPLEHPEYSEEIFLRENDLDLNAHVNHSLLGEWSLSCLPDELKQGRLLKELDIVYRSECTLEQGSVISLGAAFNSLGNSEDGTFYLHSLKTADHSREFSRAISCWQCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP72</accession>
    <name>D6SP72_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869868.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1920"/>
    <dbReference type="EnsemblBacteria" id="EFI34548">
        <property type="protein sequence ID" value="EFI34548"/>
        <property type="gene ID" value="Dthio_PD1920"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1670289at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="263" mass="30655" checksum="40B4C783B87A2053" modified="2010-08-10" version="1">MKRLLYIIFPVLIFFMLPGCLEQKEDTDDFDQAEYYFSTGQFNQARNLYQQYIDENEHGRKRYQAWNRLLSISVDIYNDIEGGLDILKAMQMEYDGELDTILDINARIAGKYDRLGQPRESRRLWKKNKELAQSGKERKKAALFLSKTGIQLREFERVREDLEKFSDCSGETDAELCSMIHYTRGKSYYLENDLTRAGEVLSRAYSLDAGNEYRSRAGLLLTEVLLDQDKVDQAVDLLKEILDIHPNPKAIEARIEHLSSIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP91</accession>
    <name>D6SP91_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869887.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1939"/>
    <dbReference type="EnsemblBacteria" id="EFI34567">
        <property type="protein sequence ID" value="EFI34567"/>
        <property type="gene ID" value="Dthio_PD1939"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1833920at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088256" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="18858" checksum="5D3FFCE9D845A063" modified="2010-08-10" version="1">MKRYLIFSILLLALLAAGCAKKPVDPAEPEPPEPEVAQPEPEIPEPAEEEKPEPMDKRALYEEVYNALPTSHTVEKGECLWWIAEYNEIYNDPFMWPLIYKDNRDQIDNPDLIYPDQVFSIPRDFEKNELTESRREAGAPQPYLPDEGARLPAELREDLGWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP99</accession>
    <name>D6SP99_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869895.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1947"/>
    <dbReference type="EnsemblBacteria" id="EFI34575">
        <property type="protein sequence ID" value="EFI34575"/>
        <property type="gene ID" value="Dthio_PD1947"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034391">
        <property type="entry name" value="Cmo-like_SPASM_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01387">
        <property type="entry name" value="BtrN-like_SPASM_domain_contain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="10"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="357" mass="40558" checksum="9A8AC5F3F600AFB9" modified="2010-08-10" version="1">MGLMRILGSWGYPALDWIQVGITTRCNAECIYCPSPVFRKKDPGRHMSMQTFTGLSRAFPRAGLVYLQGWGEPMMHPEFMFMLKMVKDKGTKAGVTSNASLLTDERIRRLVDQGLDVLGLSVAGVDEANDRIRPGSPIKKVRQAVENVHRIRTLMGSSTPALHLAYMLLGSRRGDIRRMPGFFNALAPDQVVVSTLTLALDQEMDKEMYPARDKDDFEEFKAELLDMKSQVDGQEKVFFHVYNPYLPDGPCSENIHRACYVDVDGRVLPCVYTDVSAEDRVYRYFQGRPHPVYPIDFGHVPDDSLKSIWKSRQYRKFRGRFSAGECPEECATCTKRFIDDLTHEDPEPIRVDYTGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPB5</accession>
    <name>D6SPB5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine biosynthesis Thi4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869911.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34591">
        <property type="protein sequence ID" value="EFI34591"/>
        <property type="gene ID" value="Dthio_PD1963"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="11"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="472" mass="52007" checksum="FA552BA398A950A5" modified="2010-08-10" version="1">MAEKDSVKEYDVIIVGCGPAGLFAAYYLGEHTDLNVLVLEKGKSSRKRLCPINGEKECMRCRPCNIMSGVGGAGLFSDGKLNYIHKLGKTDLTQFMPVSKASELIRDTEEIYNRFNMDGKVYPTDWEKARKIRKDALKNGIDLLLIRQKHLGSDKLPGHISAMAEYVRGKGVNIHTSEEVKDILVEQGRVQGVATSRREYRAPSVILAPGRVGAEWMGDLARRHGLNISQRGIEVGVRVEVSRDIMSDLCDVIYDPTFFIRTNTYDDQVRTFCTNQGGFVALENYQDFVCVNGHAYMDKKSDNTNFAFLSKVVLEDPVTSNQAYGESIGRLATIIGGHRPILQRFGDLRRGRRSTWNRVRNSFVEPTMKNVTCGDIAMALPERILRNIVEGLEKLNKVIPGVASEGTLLYAPEIKFFATQVQSSNVLETAVKGLFVAGDGPGVAGNIVSASATGLIPAKEIAWRHATGAGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPE5</accession>
    <name>D6SPE5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongator protein 3/MiaB/NifB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869941.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1993"/>
    <dbReference type="EnsemblBacteria" id="EFI34621">
        <property type="protein sequence ID" value="EFI34621"/>
        <property type="gene ID" value="Dthio_PD1993"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="357" mass="39670" checksum="BD968D630E20E21B" modified="2010-08-10" version="1">MTCFIQPATSEVLRKAENFEELSPEEIVYLLRLQLDSPDVYALMHAAAMMSRRTFGLKGERHMHIGLNVEPCRFDCLFCSLTGKAGIFTESVEFSTEQLLDWARLGQAQGADALNLMTTGFYPFEKLLELGRLLKSEGVNVPLVANTRDITHQEGKALLEAGFSGCYHAIRLGEGRDTPFSPDRRRQTIQVIKDVGLRWMNCIEPVGPEHSPREMADLILLARRMGATYSGVMRRINFPGSPMQKHGMINERELARMVAATRLAMGDVPRAHCTHEPHTASLMAGANLFFPEVGSSPRDLEDDSGKGRGRSLQDCALIYQEMGLDPWLESNCFQPDALPLSERANVCGNLTGITAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPI1</accession>
    <name>D6SPI1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase, subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869977.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2029"/>
    <dbReference type="EnsemblBacteria" id="EFI34657">
        <property type="protein sequence ID" value="EFI34657"/>
        <property type="gene ID" value="Dthio_PD2029"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="129"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="594" mass="65992" checksum="14B51A8A863D385E" modified="2010-08-10" version="1">MDPGSALSQPESSGIKTPRALVRQARSGKLLSFDGLEGIIKAHTAEEVLPALQQVEQQVEGHSLFAAGFVSYEASLAFDPYLKVRPDDSGFPLLWFGLFSGMRETELPRPDSRVSLEGLNWSPSITPGEYSSSLDRIREYIRAGDTYQVNFTYRLRAECSLDPLDIFCTIYRSQDPPYAAFIDTGEFALCSFSPEMFFTLKGQTLRSRPMKGTAARGLDNIQDRHAARELEKSEKDRAENVMIVDMVRNDMGRIAHPGSVHVPQLFSVEKYFDVWQMTSLVESSTSAPLDAIFSSLFPPASITGAPKIRTTEIIAELETAPRRIYTGAMGYVAPGRQAQFNVAIRTLLLDQTKSLAEYGIGGGIVWDSRTDMEMNESRVKARVLATPGPGFDLLESILWQPSKGFPYLSMHLERLQESAEYFDFPLDLQRVHSELQDLGAALPQEPHKIRLLVSRKGAVKVQAVKLDTQNPGFSRLPLAASAVDPDNRFLYHKTTNREVYNQALAARPGCRDVLLYNHRGQATESTIANLAVEKNGELLTPPVSCGLLPGVYRSLMLEQGVIRESVLSIQDVLDSPRVFLMNSVRGMHQVDIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPL8</accession>
    <name>D6SPL8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="5 8">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="5 8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2066"/>
    <dbReference type="EnsemblBacteria" id="EFI34694">
        <property type="protein sequence ID" value="EFI34694"/>
        <property type="gene ID" value="Dthio_PD2066"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="19540" checksum="D171CD393746B011" modified="2010-08-10" version="1">MGGKSEKQALILVYTGEGKGKTSAAVGQALRALGAGLSVGFGQFFKRDSQSGEQKILKKLLPAGMFLASGEGFYRDGHDHERHRAKALDLVDWAGEKIQGKAQMLVLDEALYALNRGLIDRRELEFILDGAANSGTTLVLTGRDLPDWLKDRADLVSEIHLIKHHFEQNIPARKGIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPP0</accession>
    <name>D6SPP0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IcmF-related_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870034.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2089"/>
    <dbReference type="EnsemblBacteria" id="EFI34716">
        <property type="protein sequence ID" value="EFI34716"/>
        <property type="gene ID" value="Dthio_PD2089"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="110169at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025743">
        <property type="entry name" value="IcmF-related_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14331">
        <property type="entry name" value="IcmF-related_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related_N" evidence="2">
        <location>
            <begin position="181"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1218" mass="140456" checksum="B27E2836FD398A14" modified="2010-08-10" version="1">MDINFIGIITQVFTRILRSFREFIPGPPWVSTLVLALIAALIIGLVMYIVNRRKKGGKAKKSGPAQPPPIPRKSLVRIWKAFVRRMPWDIRRYLGDFQPFFVMGEAGSGKSSLISACTDWEGKALQFQPSHVDSPLMQCYMGARAVVLEMPSIILTDVSSGAHRALKNLLKQMPCKKEFQVVITLNGASLEDEDPENLKKLARYMRGKISLMEIGKRPVQVRLALTHMDQVHGFVQWMDFLQKHRLSPQVSWDEKIYSPDLARVQDGYERLLPRALTSMSSRDYLAMVGFLKDFRQRMQILQEFADVLLAPDPFSKAPQIAGLTMHGSGQENATGNPFETGKEAMVYRQAWPANRKHQVAAAGIFLAASLGLVSAFGMEYRDLTRLDYYVEAAERRPPADYAELHSLFPLAQYQGIYHRVLPRFFPESEEVIVKRLTDIIRKHYLYPELYSLRTQVDNAQPLVYLLGLIYASPNNPLGPMILTRSHTWAENLDLPRQLVEDYASSNQYLPDVIAEVDIISHIRPQTLDPSEDATNWTFFLRRVEKLLQAPYMSPKMLEEVQDLAEPLLDLMQEVYSYPMLYEVVEHLQQVAGVGPEIQWVQRRDRNIRQKELLELLKLVSRSSLETPDVQDRSLHSLFDLMDSLSERAPDERPVLNIFMDRRNFRISMQEWVDLEMRSKKTLMMRQFAQERQQSRGLIFFEETDDFPHIHLNPAGEGTLFFAGRARVDGLFSAKAFEKRVRPGVISLDEKLEETGVSQEEQDRFAEFVERQLESYAERYVESYVNYYHQFHIRAHSEGTLRFVLNEIPTRHSPFLRFLLTLHENTSLDTSGSPLFRSFANQLEKFGFVRNLMHEEDGVIPEWRNYTAFINQMREELDGRAPWMSQDDGAETFKERLSPLGRISFTALQDDPDAYVNLVRKWLSGLGVDPEWRGPFLEPFLLAFNLGRSDIENTMAKVWQDIRGEHISHLQRRFPLDPTAEARIDPAALEDVIHPEDGDFWEDFEEFLGPFFRESRDGWVQRDASRDRINLPRGMLTTVNELHRIAGNLWDREGEPRPLVFNVLPTRLPAARDRANVPVVAYLRSGESSVFAFNQQPDWQEVRVKWWKSDAAVAGMGFQSPSTNRRVHRELRLDEQHWGLFSLLKKARPLHEDTFAWSLESPWGGSITVEFTFEADPWEAVSLQERRPRDFTPVTPEAADERSVLSVGIDTGTILEDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPW7</accession>
    <name>D6SPW7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIRAN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870109.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2170"/>
    <dbReference type="EnsemblBacteria" id="EFI34793">
        <property type="protein sequence ID" value="EFI34793"/>
        <property type="gene ID" value="Dthio_PD2170"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50300R6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIRAN" evidence="3">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="15290" checksum="C348C74C0A3A8C15" modified="2010-08-10" version="1">MQRRGFISMLGAYFGALVFGGKLPEAKARVIPKPVSLFQCHVAGFPYYQGPKIFSDLQSGQKLKLLREPNNPYDSKAIAVFTSNGHKLGYVPRTHNPLPADLMDNGHKLTASLSSVSPDMGEYSCLEMGVFVVSGGWQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPY7</accession>
    <name>D6SPY7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylate/guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870129.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2197"/>
    <dbReference type="EnsemblBacteria" id="EFI34813">
        <property type="protein sequence ID" value="EFI34813"/>
        <property type="gene ID" value="Dthio_PD2197"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033TXZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="28879" checksum="D01378B94AEF8915" modified="2010-08-10" version="1">MSTPDNHADIHKLVESELDKAELIWEQVSRHLDFSKRASLKALLEDSIPTQIPGYPYLEDMKPKVDYFIALVADMRDSSKHLLEAISAKKAKVSQLQRVFYETSALLPALAKTVSDHDGKVTEYLGDGVLALFRAYGEDRETSIRQSYRAASQCLSVTHEVVNNALEKRYSLPPLQIGIGMAMSQAVVTLVGLKEYVQPKVFGECVFRASKLSNGNDEIHVDEFLYQSWPIGKKGMLNFKRTIKNGVNGYLLERSGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPZ0</accession>
    <name>D6SPZ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870132.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2200"/>
    <dbReference type="EnsemblBacteria" id="EFI34816">
        <property type="protein sequence ID" value="EFI34816"/>
        <property type="gene ID" value="Dthio_PD2200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="247" mass="29370" checksum="75449F2F3E90C96C" modified="2010-08-10" version="1">MNKIKIDDLKDILQIIEGARNQTLERIRIAERAKYKKIRKVISDFPFKVLNLDDDFVKKIEVNDIDLEKRIEETKRWEIKESRREKIDKFIKSEKKEVEELNRIEEEVKRLEKSGFNKFEELDPGSRKKIGDMVKEDAERLENAKIAARMFEQERKTRKKEELTKILFKLICYAILFLIVFIPLISFFIFFGDTLKDLFGVFLGIFVLGGIIGCAWMFGVTALLLWLVGMTPWKYFVYDAIEWDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ09</accession>
    <name>D6SQ09_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870149.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2226"/>
    <dbReference type="EnsemblBacteria" id="EFI34835">
        <property type="protein sequence ID" value="EFI34835"/>
        <property type="gene ID" value="Dthio_PD2226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="19"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="296" mass="32667" checksum="DE5FF508A4599FD0" modified="2010-08-10" version="1">MQPGEKEQNNLSGSSLLQVRSLCIDFESHGEVHRAVDGVSFSIAPGEVLAVVGESGSGKSVTGLSLTGLLPPPPGCRVGGEVLYQGRNLLECSARELRQYRGKQIAYVFQEPGTALNPVFTIGHQIAEAIRLHRPEVKDIKAEIVKALDMVKIHEPERRFEDYPHQLSGGMQQRVMIAMALACNPRLLVADEPTTALDVTIQAQIINLLRELRERLGMSIMLITHNFGIVSGFADRVAVMRHGRIVEQKETSVILKSPEHPYTKALIGCIPVLGRKLRRLPTIESETRQEQEHGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ48</accession>
    <name>D6SQ48_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870188.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2265"/>
    <dbReference type="EnsemblBacteria" id="EFI34874">
        <property type="protein sequence ID" value="EFI34874"/>
        <property type="gene ID" value="Dthio_PD2265"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="860559at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="288" mass="31595" checksum="AB6A629F4FF98364" modified="2010-08-10" version="1">MNIPRPVLDLNLAITFATIVDCGGFTEAARRLNRTQSSISMQMKRLEDDVGKRLLNRRPGQIALTPAGEVLLDYARRMLHLNEQAWQALKIPGVAGAVRLGIPDDYAFYLPDILARFAELYPGVTLDVRCELSVELMQEIRGGNIDLALVTRQPKSPGGHVLRSEQLVWAAAVHTATEHQEVLPLALFPEGFCVFREMTLEALAGAGREWRIAYTSRSLEGLRSAVSAGLAVTVVTRSMLRGELREIEPEGPAGLPVLPAVEIALHRSPGRPSEPAQRLAELIQENLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQC0</accession>
    <name>D6SQC0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870260.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2338"/>
    <dbReference type="EnsemblBacteria" id="EFI34946">
        <property type="protein sequence ID" value="EFI34946"/>
        <property type="gene ID" value="Dthio_PD2338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010744">
        <property type="entry name" value="Phage_CI_repr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07022">
        <property type="entry name" value="Phage_CI_repr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="1">
        <location>
            <begin position="84"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="22912" checksum="6DB02DE75EF5E260" modified="2010-08-10" version="1">MQFEDFFQRVARATEINTQRQLADILGVGATAITLAKKRGVPASWSLKIASVFGINPNWIQTGKGPVYQAGREGTFFVPRVSARACAGGGSLDVRDNIVDEIPFATDWLRKKGHPENLVLMEVMGDSMSPELEEGDNILVDLGQKKITGRSPFVLGLEEGLQVKRVESAPGIVILLSTNPRYSSITLHGDEVDSLRIVGRVLWSSREYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQF4</accession>
    <name>D6SQF4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase FAD/NAD(P)-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="4">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2372"/>
    <dbReference type="EnsemblBacteria" id="EFI34980">
        <property type="protein sequence ID" value="EFI34980"/>
        <property type="gene ID" value="Dthio_PD2372"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="284" mass="31810" checksum="C1AD5CB08413F99E" modified="2010-08-10" version="1">MMDIQQYLTENNPYLPELGTIVETIQETHNIMTFRVVLDGDSRMQDFSFEPGQVGQLSVFGTGEATFVINSPPTRKEYLQFSVMRAGEVTTKLHSLTKGDRIGVRAPLGNYFPYESMKGKDILIVGGGIGMAPLRTLLLFMLDNRDDYGRIQLLYGARSPQDMAFSYELPDWLERKDLETVLTIDNEAEGWEHRVGLIPNVLLEMAPTPQNAIAVTCGPPIMIKFTLQALKKLGFEDNQIITTLEKRMKCGIGLCGRCNIGTSYVCVDGPVFSYEQLRALPNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQK1</accession>
    <name>D6SQK1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870341.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2421"/>
    <dbReference type="EnsemblBacteria" id="EFI35027">
        <property type="protein sequence ID" value="EFI35027"/>
        <property type="gene ID" value="Dthio_PD2421"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="33"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="182" mass="20687" checksum="8D7EB3B9D7D0B81A" modified="2010-08-10" version="1">MKRGVWSTLVALFICMAMLGASHAWAEEMDNFPEENIQVPEEAVHQDYLGISDNENFVIGDVQADLVLVQVFSMYCPICQREAPDVNDLYDMIHEQGLEESIKIFGIAPGNSSFEVSVYRDRYEVEFPLIPDPDFVWHKYLGEVGTPTYYAVDPENGRILHSHTGPFRDGVEAYLEEVKAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQM2</accession>
    <name>D6SQM2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide peptidase SppA, 36K type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870362.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2442"/>
    <dbReference type="EnsemblBacteria" id="EFI35048">
        <property type="protein sequence ID" value="EFI35048"/>
        <property type="gene ID" value="Dthio_PD2442"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1318587at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="106"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="296" mass="32560" checksum="5E5088FAC6B34F1B" modified="2010-08-10" version="1">METSKTKFSQRHPLIFGFMLIITAVVTFMLAMAVFNFLFFDGPKLRTQPKIGVVNVSGLITDSRDIVDWIQELEEKDSVKGVLLRVNSPGGVVAPSQEVFRAVKDLAREKPVVASLGSVAASGGYYAASPAGVIVANPGTLTASIGVKVTLTNIQELLQKLGIEDQGVYSGEFKDAGTVSRPMTEEEREYFQGLVDDMHEQFVQDVALARDMDEQRVYDLADGRAMTGRQALEAGLVDELGGRSEALDILCEKVQLPRDAKQLEGPEERMSILRRILSEFSLGDNIPGPRWIFTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQU0</accession>
    <name>D6SQU0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870430.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2510"/>
    <dbReference type="EnsemblBacteria" id="EFI35116">
        <property type="protein sequence ID" value="EFI35116"/>
        <property type="gene ID" value="Dthio_PD2510"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904889at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="181" mass="21078" checksum="431622D269028140" modified="2010-08-10" version="1">MSAGSRKESGSDKNRKMSRRDLFKGVFNKVRGNKAPERESSGLDPDMAYADRLIRQGEYEKAAHLYSRRLKKEPRHLEAMRSMGYCHFMQGDYSRAREAWEKLLGFRPRDNFALLYTGLACARQGDVHEALENWKLYYDIRKPAVQRAINLFLARQERGEELDAREMADSVQEALEKQKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQU3</accession>
    <name>D6SQU3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="2">PNP synthase</shortName>
            <ecNumber evidence="2">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdxJ</name>
        <name evidence="3" type="ORF">Dthio_PD2513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870433.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2513"/>
    <dbReference type="EnsemblBacteria" id="EFI35119">
        <property type="protein sequence ID" value="EFI35119"/>
        <property type="gene ID" value="Dthio_PD2513"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1159993at2"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="1-deoxy-D-xylulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-amino-2-oxopropyl phosphate binding" evidence="2">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="26761" checksum="313AB2C2D071B2BD" modified="2010-08-10" version="1">MPVLVVNVDHVATLRQARMGSEPEPVTAAHLAEIGGARGIIVHLREDRRHIQDRDLRLLKSTLTANLHLEMAATEEMQGIALDVLPHMVCLVPEKREELTTEGGLECRGREGFIRDYLEPFKERNIHTSLFIDAEPDQIEAAASSGTEYIEIHTGHYADAPDSPSKKTELDKILAGIRYAHLLGLKVNLGHGLNYQNILAFAAVENICEYSIGHSIISRAVMVGMVRAVEQMNEIIRGFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQU7</accession>
    <name>D6SQU7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartokinase</fullName>
            <ecNumber evidence="13">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Dthio_PD2517</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="13"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870437.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2517"/>
    <dbReference type="EnsemblBacteria" id="EFI35123">
        <property type="protein sequence ID" value="EFI35123"/>
        <property type="gene ID" value="Dthio_PD2517"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="264"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI35123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="422" mass="46141" checksum="D205FD652F817DA9" modified="2010-08-10" version="1">MRVIVQKYGGTSVADVECMLKVRERVLKALDKGYKVVVVLSAMSGETDRLLSLARTWSKRPDPSEMDVILSTGEQTSVALFSMLLKDCGVKARSFLGFQIPIQTDRSFGKARILDIEKDYIFDILKDYDVLAVAGFQGCDCEKRITTLGRGGSDTSAVALAAALDAEVCEIYTDVDGVYTTDPNICSQARKLKKIAYDEMLEMASMGAKVLQIRSVEFAKKYNVPVHVRSTFTQNPGTLVVQEDKSMEAAMVSGVAYDKDQARITLVDVVDAPGSAAAIFEPISRANIVVDMIVQNPSRESGRTDMTFTVPKGSSEDTLNILKKIKDKIGAREILHDSGVAKVSVIGVGMRNHSGVAAIAFSALKRENINIKIISTSEIKISCLIEEKYTELAVRTLHEAFGLADMQEGAVEDRAQCKVEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR07</accession>
    <name>D6SR07_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870497.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2582"/>
    <dbReference type="EnsemblBacteria" id="EFI35183">
        <property type="protein sequence ID" value="EFI35183"/>
        <property type="gene ID" value="Dthio_PD2582"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="180"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="43670" checksum="0B06369DE4D91AF0" modified="2010-08-10" version="1">MIYRRILPEIQSALQRQAAVALMGPRQVGKTTLALTLGNTLPSLYLDLENPADRQKLTEPVLFLSRYEDQLVILDEIHRTPELFQSLRGIIDSGRRAGKRTGRFLLLGSASVDLLRQSGESLAGRIAYVDMSPLDVLEVADDSRKLFDLWIRGGFPDSFLADDNASSLALRRDFIRTYLERDIPIFGPRLPAQTMERLWTMLAHVQGSLLNASRLAASLGVSSQTVTRYIDLLADLLLVRRLAPFHANLGKRLVKSPKVYIRDSGLLHALLDISDYNELAGHPVAGASWEGFVIENILAAAPIRTRASFFRTSAGAEIDLLLRLPGGELWAVEIKNSLSPRLEKGFHLAHADLKPSRSFAVYPGKDRYPLNKNVDAISLLEICTLLAGTGRNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR24</accession>
    <name>D6SR24_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0460"/>
    <dbReference type="EnsemblBacteria" id="EFI33140">
        <property type="protein sequence ID" value="EFI33140"/>
        <property type="gene ID" value="Dthio_PD0460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="65" mass="7468" checksum="788745312FE3C3F6" modified="2010-08-10" version="1">MHVIHGPHDKIFKRVMADRENAIISASVYLANQIYMDELLKNIVVKELCGVCRLICIQNTLKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR60</accession>
    <name>D6SR60_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0499"/>
    <dbReference type="EnsemblBacteria" id="EFI33176">
        <property type="protein sequence ID" value="EFI33176"/>
        <property type="gene ID" value="Dthio_PD0499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="31" mass="3385" checksum="07C0F5429DA24672" modified="2010-08-10" version="1">MIIPASQASNLMNGLANSLKELEGRLKEARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR70</accession>
    <name>D6SR70_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rtcB</name>
        <name evidence="5" type="ORF">Dthio_PD0512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870544.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0512"/>
    <dbReference type="EnsemblBacteria" id="EFI33186">
        <property type="protein sequence ID" value="EFI33186"/>
        <property type="gene ID" value="Dthio_PD0512"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1384936at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="322"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="397"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="474" mass="51275" checksum="B44697C2B07CA811" modified="2010-08-10" version="1">MQKPTRVSSYIHRLEPEGPMRVPGFIFADDELLADMEGDVFRQLANVATLPGIVHGALAMPDAHLGYGFPIGGVGAFDPHQGGIVSAGGVGFDIACGVRTLVTGIHKDRVLAERKTLADLLYQNVPAGLGTKKGLKISGRDMDRMLAQGGKWAVGRGYGTSSDLKKTEEGGTASGADPLAVSDKARKRLDRELGTLGSGNHYLEVQAIQEIFDDNAAQAFGLRKDDVVISIHCGSRGLGHQVATEYIRLMVQESARQKIRLPDRDLACAPIFSDTGQQYLGAMRAAINCALANRQILSHLARESFETVFPDARISMLYDVCHNTCREEDHEFQGRSIRLFVHRKGATRAFGPGHPDLPAEYVQVGQPVLIGGSMGTSSYIMAGTLEGMGISFGSACHGAGRVMSRKQAVKKYPGRQVIDHLQKMNIEVRSHSFKGLSEEAPEAYKDVSRVVEVSHNSSLARKVAKLKPMICIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRA1</accession>
    <name>D6SRA1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870575.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0543"/>
    <dbReference type="EnsemblBacteria" id="EFI33217">
        <property type="protein sequence ID" value="EFI33217"/>
        <property type="gene ID" value="Dthio_PD0543"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1991809at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="113" mass="12803" checksum="8FE023FD4311555D" modified="2010-08-10" version="1">MHGNSNLLETAARILGVEVWAAGSEIRYSYYRLMSMYHPDKNPGDPEAQRLSALINEARDILLGKETRASLIKDPVLVSQFLNTPVEEGEVLSYNEWLKSRFYDIKGCSIWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRK2</accession>
    <name>D6SRK2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870676.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0645"/>
    <dbReference type="EnsemblBacteria" id="EFI33318">
        <property type="protein sequence ID" value="EFI33318"/>
        <property type="gene ID" value="Dthio_PD0645"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="952726at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="572" mass="62785" checksum="9CE476ED7D5DAA76" modified="2010-08-10" version="1">MPRITIQPINIRADAREGETLRDILLRRGVYVESPCNGNGTCGSCGVWIQEHQQVPYTPNENITESDLEKGYRLSCQVVPEEDLTINLPMNFLRDAKRFRESQTILEGEIAPVSRLVSAVKILDEQDYPEMLYDNFPEPRVLKVWEDEYEPKGLAIDLGTTTIVVTLVSLETGVVLSTASKLNPQISFGHDIMTRIQHGSTQEGLHELAQAVRKGINELIYEVCVDSDSKRKEILDVVLGGNTTMLQIIAEIDPAPLGQIPFTVDMKSGISYPVQQFGIKVNPDARVYIPPVMHAFIGSDITAGLLIHSDFFDDTKSVLFVDVGTNGEIALNYLGRRLACSAAAGPAFEGMGLSCGMRASFGAVESVKSNSDSITFSTVADSEPRGICGSGIVDLAAALLRLQVIDPTGRFCSLPCNSVPESINTRLKEVDGQTVFEIGPQVSFSQRDVRQIQLAKGAIRAAIDVLMDEAGCTVDELDNIVIAGGFGFYLNPENLETIGIIPRGTKDRVEFAGNACRSGCVWMLTDISYRRFLEINLQDIEHISIAQSPKFMELYAESMEFRDAEFEIAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRM2</accession>
    <name>D6SRM2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="6" type="ORF">Dthio_PD0666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870696.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0666"/>
    <dbReference type="EnsemblBacteria" id="EFI33338">
        <property type="protein sequence ID" value="EFI33338"/>
        <property type="gene ID" value="Dthio_PD0666"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7655" checksum="E9747FFEA553423C" modified="2010-08-10" version="1">MPKIKTRRCAAKRFSITGSGKVKRRQQNKRHILTKKNAKRKRRLGKPAIVDKANMSSVKRMLPHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRN0</accession>
    <name>D6SRN0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0674"/>
    <dbReference type="EnsemblBacteria" id="EFI33346">
        <property type="protein sequence ID" value="EFI33346"/>
        <property type="gene ID" value="Dthio_PD0674"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="36326" checksum="E1094E3347061CB8" modified="2010-08-10" version="1">MDQTLTFKNSLMKKLPSDNIILTHKGALGDFLLAWPAFLSIRTFFSQAEIFWHGRDDFLPWLRPLNIKKVPHRTASALDGLYSRSTWPESLRKSTVFWFGLDRVTIACSHPQLFFLTAVDFARKRHVRYNYLYQLEKLGISFYRNWQESWKDMFAKQDTQDLALIFPGSGNPAKNWPVKNFIWAGKRFQSAGLKPLLVLGPAEEKNGISESSLQQTTCSSLEDLQGLILKSRVLLGNDSGPMHLGAMFSKPGLVLFGPTPLYMWRPQGMRVLKSPAHCAPCSKTARVQCQEPTCMQAITREKVQAWMDKFLYCQRTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRQ5</accession>
    <name>D6SRQ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870729.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33371">
        <property type="protein sequence ID" value="EFI33371"/>
        <property type="gene ID" value="Dthio_PD0700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335SC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063281at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="8206" checksum="7C77509594A69A06" modified="2010-08-10" version="1">MSPIETDHETIKRIFKESLAETLHENRQLFEEIITDVFEDLALSEAIKEGKETEKVSREEIFRTLEQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRS0</accession>
    <name>D6SRS0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870744.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33386">
        <property type="protein sequence ID" value="EFI33386"/>
        <property type="gene ID" value="Dthio_PD0717"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031MGR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="12499" checksum="2EC270F3A8C5C28E" modified="2010-08-10" version="1">MSQWLAEQSLGKPPMVYEIELRERMVRVEEELRNQRELIQYIIEQMDKRFEQVDKRFEQVDKRFEQFDQRFMALTKRMDRLLIWSFGTTVTVGGLIVAILKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRS9</accession>
    <name>D6SRS9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0726"/>
    <dbReference type="EnsemblBacteria" id="EFI33395">
        <property type="protein sequence ID" value="EFI33395"/>
        <property type="gene ID" value="Dthio_PD0726"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RSF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018700">
        <property type="entry name" value="DUF2204"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09970">
        <property type="entry name" value="DUF2204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="157" mass="18383" checksum="AF0CEA149E9F7CAC" modified="2010-08-10" version="1">MLMSPDFKELLKLFEKHNIRYLIVGGYAVMKYSEPRFTKDIDMLIATDQENAKSVYLALKEFGAPLENIDQDDFAHEGYFYQMGRPPLRVDIMMSIPGIEFDEAWNNREVVELDDLKLFFISRSDLIRAKEKSGRQQDKIDLKILKEAERLDALDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRU9</accession>
    <name>D6SRU9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional modulator of MazE/toxin, MazF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870768.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0747"/>
    <dbReference type="EnsemblBacteria" id="EFI33415">
        <property type="protein sequence ID" value="EFI33415"/>
        <property type="gene ID" value="Dthio_PD0747"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="111" mass="12163" checksum="C8DF50365D9EBDC1" modified="2010-08-10" version="1">MYVPDRGHIVWLNFNPQTGHEQAGHRPALVLSPASYNGKTGLALFCPISNKIKGYPFEVMIKGHTSISGVALADQVKNLDWRARGLKFAASVDESILEDVIAKFEALLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRV5</accession>
    <name>D6SRV5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870773.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0754"/>
    <dbReference type="EnsemblBacteria" id="EFI33421">
        <property type="protein sequence ID" value="EFI33421"/>
        <property type="gene ID" value="Dthio_PD0754"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50315HT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="125" mass="14528" checksum="EE7549FA8478CE22" modified="2010-08-10" version="1">MGVQSVKELIVYQKAYKLAMHIFEISKMFPDEERYALTSQIRRSSRSVCLNLREAWAKRRYEAHFISKLTDCDGENNETDTSLDFAKDCQYIKNEQHAELTSLCKEIGNMLGSMINNPQPFILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS68</accession>
    <name>D6SS68_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mutL</name>
        <name evidence="8" type="ORF">Dthio_PD0868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0868"/>
    <dbReference type="EnsemblBacteria" id="EFI33534">
        <property type="protein sequence ID" value="EFI33534"/>
        <property type="gene ID" value="Dthio_PD0868"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="764332at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="7">
        <location>
            <begin position="214"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="6">
        <location>
            <begin position="404"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="580" mass="64569" checksum="B305FF7601A19A2E" modified="2010-08-10" version="1">MGDLSVNGIKVLPPGLQNQIAAGEVVERPSSVVKELVENSLDAGAGSVQVYLEQGGQALVEVVDDGAGMLPADMALAVTRHATSKIFSMQDLVSVQSFGFRGEALPSIASVSRLRLSSCVQGRDEGSFLEILYGDHLEEGPEAMDPGTRVKVQNLLANIPARLKFLKTKNTEAKKCSENFIRLALANLEVDLELYSEGRSLHRFFANENLKERLSRVWPEQLCRDLKEVELDQGDFRVHGVASAPENAQARGERMLFYVNNRAVKDKTLISALKQAYKGRLLSREYPQAVIFLEIPPEEVDVNVHPAKSEVRFRNEKHVFSLVSRAVGKVLDKNYFQVPEMPAEEVDVAGRADSPRYGPGPGETRPEMPVFREDFRHETAPDYGDRPPKKPAPPVHAPDMGLSYLGQVENNYLVFLNSSGRLLVVDQHGAHERVVFEDLKSRQGSVQSRMLAMPMQIELHQAEKNLLEEIWSMLRSLGFVLELQDESLLQVKGLPDILTSGEGLEALRSMLEDKARDMDGILIAMACRTSIKSGSSMTRDEALSLAHKLMQCKEMNFCPHGRPICMDLGGKELERLFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSB6</accession>
    <name>D6SSB6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="7" type="ORF">Dthio_PD0917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870932.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0917"/>
    <dbReference type="EnsemblBacteria" id="EFI33582">
        <property type="protein sequence ID" value="EFI33582"/>
        <property type="gene ID" value="Dthio_PD0917"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2027419at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="6">
        <location>
            <begin position="177"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="28652" checksum="3298D610BF687DB7" modified="2010-08-10" version="1">MKRSFFGYLVIFFIISAVALTAACSPRKVSPPTPPPRIEEPEREPVRPEPPEEKLDRARKYTVLGQTYIPLSSSEGFEEEGIASWYGPKFHGKKTASGEVYNMYEISSAHRILPMHTKVEVTNLENDKSIRLRINDRGPFVDDRIIDLSMAAAKELDMIGPGTAPVRVKAVGSAPRDELPGTFYVQVGSFTTRENAENKKGRVQEKGYSETRLQKNDSGGQTVWRVQAGRFENVGQAEKARDSLRESYPEAFIIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSF3</accession>
    <name>D6SSF3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase sigma-54 factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD0954</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the sigma-54 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870969.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0954"/>
    <dbReference type="EnsemblBacteria" id="EFI33619">
        <property type="protein sequence ID" value="EFI33619"/>
        <property type="gene ID" value="Dthio_PD0954"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1906842at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00717">
        <property type="entry name" value="SIGMA54_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="12">
        <location>
            <begin position="115"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="11">
        <location>
            <begin position="319"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="480" mass="55598" checksum="7E8E2B83AB029987" modified="2010-08-10" version="1">MSLELRQQLKLSQQLVMTPQLQQAIKLLQLSRVELLEVVQQELMENPILEEVQYQEDEQTARDVHEEANRKTSLNSEEQSMIKNADWENYLGEFSSSSKQSVHHERETPEEMQSFEARHSSKPSLEGHLFWQLQLQDFSEEDMVVGEEIIGNLDSRGYLQATSREISESTGAEQEQVKRVLKRIQHFDPIGIGSRNIQECLLVQLEALNEDDPVLTSLVKEHLEDIEKNRIAPLLKKFKVSREYMQEYIEVIRSLDPFPGSSYGSEDVVYISPDIYVYKYEDDFIILLNEDGLPNLQLSSFYTGENQLVKDKKNKQENEYIQEKTRSAVWLMKSLHQRQRTLYKVMQSILKFQKEFFEHGVSRLKPLILKEVAEDIEMHESTVSRITTSKYVSTPYGIFELKFFFNSALSMDGGGHVGSESVKAAIKKMVREEDPKKPLSDEAIAAILKENLDVNIARRTVAKYRMALDIPSSSKRKKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSF9</accession>
    <name>D6SSF9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870975.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0960"/>
    <dbReference type="EnsemblBacteria" id="EFI33625">
        <property type="protein sequence ID" value="EFI33625"/>
        <property type="gene ID" value="Dthio_PD0960"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503466S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904891at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="197" mass="22161" checksum="3B03D2083963A7C9" modified="2010-08-10" version="1">MAGFFLALITGEVFPVLLIAVFFELLWLDLIPAGTFIPPNAIFCVTSVTLLYGHFQLEHTGQIFLLMLLSIPGAYILSRIEGWYRIRQNKKYNLILRQSRDRFSSYNPGKMIMQSLVGSFGVGLVTACLGIYFLAIVYPHLKDLFQFQREMDWSLILLAASFSALAGLRVKKAYTSLVVGMVLISAALAWMQWPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSI6</accession>
    <name>D6SSI6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD0988</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0988"/>
    <dbReference type="EnsemblBacteria" id="EFI33652">
        <property type="protein sequence ID" value="EFI33652"/>
        <property type="gene ID" value="Dthio_PD0988"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="50"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="208"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="451"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="13">
        <location>
            <begin position="671"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="521"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="862" mass="96036" checksum="66CB47558EE984EA" modified="2010-08-10" version="1">MVKSYKDLAQENELLRRELKVAREAAEITSKMVVEQFEQTEQMLRRYREANAQRRAVLDAASRMSIIATDLSGNITLFNPGAENLLGYASSDVAGRMNILSLHTTEDLERHRASLKATLTSSTGMEIFEHYTSLQQHDTGEWQYICSDGTLLPVSLSITSIYNAEGMREGYLFTAMDLTLRKSLEQKLVAAKEEAEQASACRGEFLARMSHEIRTPMNAITGMAYLLGSTELNHVQQDYVRKIIDSADTLLAIINDILDFSKIDAGRMELEELPFSLQQIIGRMLNVVGARAEEKGLKIQTHIHPGVPDSLVGDALRLGQIILNLCSNAVKFTSQGEVALTVTLQKERQHQVDLLFCVSDTGTGITPEKAEQLFQAFQQADGSITRKYGGSGLGLAICKELTQMMGGEIWVESIPDQGSSFFFTACFRRNEQAEPGPDQDYPDMEAVRGTRVLVAEDNTINQQIIHEYLREAGINATIVDNGKKCLEKLQQSHYDLVLMDIQMPEMDGLEAARNIRAAEITEQGSQDTDRRPQNHSPNPPTPQSPNSSIPQSPNPSIPQSQNPSIPQSQNSQIPQSLNPGIPIIAMTAHALDTDLEKSLQAGMNDHITKPVHPDTLYRILQRWAPQAARQDSAVGSAGGNSRSIDLQKSSEHLPRIREIDMDEAMQRMNFSPELVMEMLLEFKNTYRSVPSLLRQWQDRGRWEDIQEKTHAIKGASSYIGAVKVHRDASLLEETLKSGQHNKQNISILLQNFLHSLENCLSSLDSLESRSQPESISPSPLGEREQRYAAEILGKLARTLDRGELADENRIRELDGMLRGQGFDGLLNKLLEFISEFDHDAAAEVALKIQQRINGNISDTHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSJ0</accession>
    <name>D6SSJ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0992"/>
    <dbReference type="EnsemblBacteria" id="EFI33656">
        <property type="protein sequence ID" value="EFI33656"/>
        <property type="gene ID" value="Dthio_PD0992"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1819626at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="349" mass="38236" checksum="3A243841D9DC0BC5" modified="2010-08-10" version="1">MNSMSISKIIFFLLGIAGLLFMALIFGTQELGQALSRVSPLAVAVLFTLQLSTLLASAWIWHFLLTRKTSITFSTVFLVNQAAGLIESLTPSVKFGGEAAKVYLFRQKTGQAYQDLAGTLLVHKFLTMTPFVLLCLMLVLPAFFMFELPGYFYAALAVLTAMCVGLGFLCYGRKGEERNEKPLQDAPRKIAQGRLESLKKTPSRIALFLQQSRLAASSLLSTRQTFAAMLVSLVIWVFYPVKVYLACTFLGLEVHPLIIGLATLFAYMVSMVPLLPGGLGTYEGAMALFFTMGGLTPAEGLAVSLLSRLTTFWFPLLVSALCCLTLSRTSPLLPEKPGIQEKEQVKQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSM6</accession>
    <name>D6SSM6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1031"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0711">Selenium</keyword>
    <keyword evidence="7" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="5">
        <location>
            <begin position="301"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="7">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="441" mass="49878" checksum="2ED734B99DA73438" modified="2010-08-10" version="1">MSTQVSRQELADFLKPRLNARFQTWLQICANCALCADTCHFYLADNRNPEMIPAYKVRFINEILKGKAEINDDYLQKMYSTLFHECNMCRRCALYCPFGIDVGIMVALQRAMLHNVAGMRPAGLMAAIESYKQFGNQMSLTQEDWVDTIEWTIEELEDDYPALEIPIDKQNAELLYTVNAREPKFYPQDIQEAAIIFNAVGESWTVPSADGWDDTNLAMFCGDLGTAKMLVQNTFAQADKLNAKKVAISEUGHAYRALRYEAQVWMGHEPKQEVVHAVELYHDYIASGRIKLKEKVKVPTTLQDPCNVIRSGGLAEKNQRLAEMLSEDFRPMEHQGNYNFCCGGGGGAMPMGGEMRPHRVKCGKIKADQIRATGAELVFVPCHNCIDQIRDLNKEYDLGIKAVHFKEVIAHNMVIPEHMLSKDDQGQESAVQEEPETEEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSP1</accession>
    <name>D6SSP1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871056.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1046"/>
    <dbReference type="EnsemblBacteria" id="EFI33707">
        <property type="protein sequence ID" value="EFI33707"/>
        <property type="gene ID" value="Dthio_PD1046"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1559099at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="347" mass="37558" checksum="3517789047E1F94E" modified="2010-08-10" version="1">MSLDRQTLSDGFKTVFLPWFLLLFGMFTVVYKTVTGDNLFPVYDYGELQDYTLWEIPYVYILNYATRAWGTLLFAFMLGGVIAAFVPKEKMKKYLTSKNFSSYVLAALLAPAMTVCSCAMIPIFGGLVVAGAGVGPAVTFLLMAPAANFIAIITTIDIISLEIAVARVVFAFFAAILVGYLVSMTRAAKAVEERFAGMAVQAREDYQEYRESFARKSSNALYEAGDLLKKVVPYLALGLLVVSYVDAFLPPAIVAQYLTGITGVGLSAVLGVPLYTPTLVEIFLIRALLDLGMAPAAALAFLIAAPMASIPSMLGVASLVGRRLVINYALLSVLMAFVAGSIYLYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSP9</accession>
    <name>D6SSP9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD1054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1054"/>
    <dbReference type="EnsemblBacteria" id="EFI33715">
        <property type="protein sequence ID" value="EFI33715"/>
        <property type="gene ID" value="Dthio_PD1054"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1721242at2"/>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="11">
        <location>
            <begin position="16"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="162" mass="18745" checksum="CD19F68914ECE983" modified="2010-08-10" version="1">MSTKTVYNFMLRLLTSKELAFIFRLYIGGLFVYASLYKINYAVEFAETIANYQLVPYWAVNFLAVTMPWLELICGLMLIIGFRAKAVTVIIGGMMVMFTVALVINVIQDTPISCGCFSTSDELIGWHTVLRDVIWLGMIVHIYYFDRMFHLENRFLALLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSQ5</accession>
    <name>D6SSQ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871070.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1060"/>
    <dbReference type="EnsemblBacteria" id="EFI33721">
        <property type="protein sequence ID" value="EFI33721"/>
        <property type="gene ID" value="Dthio_PD1060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="184" mass="21200" checksum="229FFAF4340C7543" modified="2010-08-10" version="1">MRPLNLLVITVIACVMAWLPSAGLAGDKEQALEIEPCTVSLRHDEFKSIQMFGRVNVTYLKGSAEELGLDRQEITEHLQELFQENFPDMERDDDLLPFFVDDPRELGYVRCIITTAGEEDPLALHVRLRSGNFIEIDGRMVVVRIYEKDDLTMSSRDSIAADVQKRLQDMMQDLSEEFYDKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSS2</accession>
    <name>D6SSS2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="4">3.1.1.61</ecNumber>
            <ecNumber evidence="4">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cheB</name>
        <name evidence="9" type="ORF">Dthio_PD1077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CheB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="4"/>
    <dbReference type="EC" id="3.5.1.44" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871087.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1077"/>
    <dbReference type="EnsemblBacteria" id="EFI33738">
        <property type="protein sequence ID" value="EFI33738"/>
        <property type="gene ID" value="Dthio_PD1077"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="8">
        <location>
            <begin position="170"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4 6">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="360" mass="39287" checksum="8A9D7D575B9B027A" modified="2010-08-10" version="1">MNRKIRVMIVDDSALVRQTLADILESDPEIQVMGTASDPFVAAKKMEADVPDVITLDIEMPRMDGLTFLRKIMAQHPMPVIICSSLTEKNSELSLQAMDAGATEIITKPRLGTKKFFEESRVRIVDAVKAAFQADLSAKRSRLPEKPRQIEPRLNADAVIPGPARGREMFQTTDRVVVVGASTGGTEALRVFLESMPLDCPGIVVVQHMPEHFTRAFAQRLDSSCVINVKEAADSDPVLRGRALIAQGNRHLLLKRSGARYYVQIKDGPLVSRHRPSVDVLFRSAARYAGKNAVGVIMTGMGSDGASGMKELHDAGAFTLGQSEASCVVYGMPQEARKLGAVDKELPLEKMAPQVLKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSS8</accession>
    <name>D6SSS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma-factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871093.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1083"/>
    <dbReference type="EnsemblBacteria" id="EFI33744">
        <property type="protein sequence ID" value="EFI33744"/>
        <property type="gene ID" value="Dthio_PD1083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12256" checksum="1FCF0D5B6599B07C" modified="2010-08-10" version="1">MNNSMQQNDIQILKLTGDCSVQNATEVLQLFSQALETAQSLALDLSEVEKSDISLMQIICAAHQSFAAREKCIRLSGLPSEPVMETWKSGGFGQVCLFGREECLFKEVGVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SST9</accession>
    <name>D6SST9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenocysteine synthase</fullName>
            <shortName evidence="5">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">selA</name>
        <name evidence="8" type="ORF">Dthio_PD1094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SelA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871104.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1094"/>
    <dbReference type="EnsemblBacteria" id="EFI33755">
        <property type="protein sequence ID" value="EFI33755"/>
        <property type="gene ID" value="Dthio_PD1094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025862">
        <property type="entry name" value="SelA_trans_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12390">
        <property type="entry name" value="Se-cys_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Se-cys_synth_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="465" mass="51454" checksum="1AD079CD784D59AD" modified="2010-08-10" version="1">MSKLYRSLPSVDSVLAGAVQDPDLAGLPRNMLRDLVNDFLDLCREEIRSGVIARESDLEASVLQPRLLAYLRAHSRPHFRRVINATGVVIHTNLGRSILTHEAAASVSEACRHYSNLEFSLDTGQRGSRYSHVEDLLCRISGAEAGLVVNNNAAAVLLVLDTLARGREVVVSRSQLVEIGGSFRIPEVMAKSGAHLREVGATNRTHLKDYRQAIGPDTGALMKVHTSNYRIIGFYKEVPLKELVQLGREHDLPVIEDMGSGNFFDFQAHGYNFMPEPTVQQVIRDGVSVVSFSGDKLLGGPQAGIILGEKKYIDPIKKNPMNRALRIDKMTLAALESTLRMYLDPELARSKIPTLRMITAGEKDLLQKARRLKNRIRRNIKADMELAVFPAQSRVGGGAFPEQDLPTTLVGIKIAGLSCQDMRNRLLNTDPPLVGRVEEDFFCLDPRTIDDSEMGMVVSVLKDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSY9</accession>
    <name>D6SSY9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871154.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1144"/>
    <dbReference type="EnsemblBacteria" id="EFI33805">
        <property type="protein sequence ID" value="EFI33805"/>
        <property type="gene ID" value="Dthio_PD1144"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="134" mass="16475" checksum="D6C33BA404BCB3EB" modified="2010-08-10" version="1">MSSAPFSKEQIDFLKEHMAQWLAEQSLGKPPQVYEIELRERMVRVEEELKHQRDMIQHIIDQMDKRFDQVDKRFEQMDKRFEQMERRFEQMERRFEQMDQRFEVMTKRIDRLIIWFFSTTVAVGGIVVGLIKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST47</accession>
    <name>D6ST47_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871212.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1202"/>
    <dbReference type="EnsemblBacteria" id="EFI33863">
        <property type="protein sequence ID" value="EFI33863"/>
        <property type="gene ID" value="Dthio_PD1202"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="164"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="32712" checksum="8B553190DFEA3AE3" modified="2010-08-10" version="1">MRGFTLSAVQRHPVMETWYVYSLSALVLMGLQRFLYKVAASKNCSTFRTTFVFMATVGVLAGAVTLIRRPEIADPGFLVFISLANSLTFASATLCHIQALKYVPVAVAYPLIRMNIVLVVLFAVFFLQESLALQQVLGLLFSLATVWILGRDKNSDFQVSGRARGLLLVFLAMLAGGLSAITCKFAADYTDIWAFMALSYIFSTLFTLALAPRMFAASQDPGPGRLALGIGLLMGLLNLAGFYLFLRALALGPLSVVAVVNGMNFLVPVLLAAIFFRERLDAYRFLGLALAVAALWLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6STF6</accession>
    <name>D6STF6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA (Cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871321.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1311"/>
    <dbReference type="EnsemblBacteria" id="EFI33972">
        <property type="protein sequence ID" value="EFI33972"/>
        <property type="gene ID" value="Dthio_PD1311"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="92"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="422" mass="46660" checksum="BA6D9494DA3F5556" modified="2010-08-10" version="1">MQVYQKTGYKRFFRWVCRGAEQEKCHDLLSSEGFDFAPVPEVPGAWVEENGPFGLGASLAGYFGFLYIQDLSSMLPPILLAPGPGQAVLDMCAAPGGKSVQLAEMTGEGGLVIANEPSRDRLGTLRANLERLNAANVVTTNYAGQAFPQGPVFDCILVDAPCSGWGTVGKNPAVTRVWKKENLHTLIEVQRKLLEKAYKMLAPGGRLVYSTCTTNEEENQNQVHWILKRTSLAGSPRAQHMQSELGLPGLESTAPGMLVMKGDESGSQSFFMAALEKPGKRAWTQENDKVNAPSSWHKLMPEGFDLPEPLEKIGLYGFSGKVFFVPDKALPYVHQGLRIKGMFAGSLKKNSFVPNPRMRIFLKGSSTMGYQVRDVQEVRALVSGQSRFFDASTRNGLVEFYWQGLPMGWLKHKKSRVFWSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6STH2</accession>
    <name>D6STH2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1327"/>
    <dbReference type="EnsemblBacteria" id="EFI33988">
        <property type="protein sequence ID" value="EFI33988"/>
        <property type="gene ID" value="Dthio_PD1327"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="426" mass="45818" checksum="2C6A19860AEA56CF" modified="2010-08-10" version="1">MSCFPGIQLKQGCSLEFYDLIFYLSMLAGLLMAFSLGANDLANTMATAVGSKALTVRQAVMIAAPLTFVGAVFLGAHVTATITRGVVNPEHIADPKLMVLGMFSALLAAALWVFIASVASLPVSTTHSIVGSVLGFGIVAGGPEVVNWAILLVVVLSWLISPIFAGALAYLIFTHIRKFIFYQKHYLEQARIWAPRWIGLTVLILGFSFVFKTPLYDAIDMGVPFAVFLIVALACLAWAFFRYLINKITRHMEQNVENVEGIFRKLQIMTSSYVSLSLGANDVANAVGPVAVIYIIVRQQELVEQADIPIFLLVMGGLGIALGIALLGARVIRTVGTRITTLTHTRGFSVNYGSATAVLVASMLGMPVSTTHACVGGVTGVGLARGFSAIDLTVLLRIVAYWVLTVPIAALTCIVIFQTLRWTFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6STR3</accession>
    <name>D6STR3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871428.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34079">
        <property type="protein sequence ID" value="EFI34079"/>
        <property type="gene ID" value="Dthio_PD1419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="433" mass="51315" checksum="D9F839FC21DA2BAD" modified="2010-08-10" version="1">MPQSPSKNLFPLLNLDMVQEFAEKILSHFPYLHATKVTLYKNTPRLAAFLPRYKTTYILVIEVLDLDRYTQQYEELKEYLKPPFNQKLFSLTGDALAGTYFNPPPPEYNHWDEWDFHLVTVNWKNIPSDYITVSKHFVTHAQQSESTAIFSNDKAISLNDKITVNRKLQVLCSRIEYFSNRIEQHDKIEDQYILTKLREKFQHTFHDFIQKSTDLCININKNVLPGDQTKITMDDDFFDASFIDNGNHFIVTYNQITNTYTKKRGFIYLRYILQNKGNEVSHKEILHELNPTPLTEINNINSEDNVEIRNEIDESVGSTPDEKAFEDYKERYLEMEEEIEDARRNKNYVLLEELMKEKEFYDSEFKNLYYTKKYGHINKTEKKIVNTVGKRLNEAIQTILTDNQELGDHLKKNITPHGHIKYRPSPDLHWKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU19</accession>
    <name>D6SU19_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0425"/>
    <dbReference type="REBASE" id="38769">
        <property type="entry name" value="M.DthASO31ORFAP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33110">
        <property type="protein sequence ID" value="EFI33110"/>
        <property type="gene ID" value="Dthio_PD0425"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HsdM_N" evidence="3">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="13418" checksum="294A483C8E678195" modified="2010-08-10" version="1">MHSDSNKRRSFLALLFVAGDVKRLDSQTIRRYYVATKHNNGANLGFENQMWAAADKLRGHMDASEYKYVVLGLIFLKYISDSFQAKYIKHPRFPPRHPPSQTHFRQTACPGCREVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU92</accession>
    <name>D6SU92_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871566.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32872">
        <property type="protein sequence ID" value="EFI32872"/>
        <property type="gene ID" value="Dthio_PD0183"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2022133at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="8748" checksum="81C53A0C79278716" modified="2010-08-10" version="1">MISFTAKYVKIGSGYMGQIVEWPEVVTEGKDIEECRVMLRDALNEMMLAYQQLGKEFPPGNALIEQLPVEIKNVGQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUB4</accession>
    <name>D6SUB4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871587.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0208"/>
    <dbReference type="EnsemblBacteria" id="EFI32894">
        <property type="protein sequence ID" value="EFI32894"/>
        <property type="gene ID" value="Dthio_PD0208"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1445800at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088202" evidence="8">
        <location>
            <begin position="29"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="59"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI32894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="470" mass="53535" checksum="762356B2FAE96FD8" modified="2010-08-10" version="1">MQTLKRLKTFVCFFLILALMVPATQAKAFIFSEFTITDEAELGTKVHSLIRSNYHVVQDPEITSYIQDIASRLEKAAPPQPFPLQVDVVEDRSLNAMATVAGYMVLFSGMITRMETESELASIMSHELGHITQRHVARNIERSQKISAGALLGILAGALVGAEAGETMAVGSMAGAQSAFLSYSREDEREADHVGMNYLIEAGYNPKGMVSAMQKIRRLQFFSGGDIPSYMSTHPGVDERISYLRNRIERLDDELLKREDDNTRLYRVQTLLRARHDDPSKALEHFRKQSEHECLANLGMGIANSRMNRVRDAEQNFEKLLSISDQDPLFLREAGRFYFQYDRLDKAGELLQKAAMLNPDDSLALLFYARVLAEKGDTDTAISYFRETLKKMPENSRVHEFMARTYGEQGDNFMAHTHMAYAHIYNNQRSRADFHMDRVRAAAQTAEQEKKVKELEKAYEQRVQFWKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUC1</accession>
    <name>D6SUC1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="3">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaE</name>
        <name evidence="6" type="ORF">Dthio_PD0215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CoaE family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871594.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0215"/>
    <dbReference type="EnsemblBacteria" id="EFI32901">
        <property type="protein sequence ID" value="EFI32901"/>
        <property type="gene ID" value="Dthio_PD0215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="329"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI32901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="535" mass="60655" checksum="630C2CE5B3A9A281" modified="2010-08-10" version="1">MGEELLFTVQESQAGSRLDRLVMQNIPRPAPSRSRVQDWIRKGNILLDGTVCLKPAHKLSAGQTVQVLAREENEDLEPVAGKLDIVYMDREMVVLNKPAGLSVHPSSSDPAPTLVHYLLYACPGLRLMTDRQRPGIVHRLDKDTTGLMVAALNQEAKEDLAGQFAGRRVHKTYLALVCGALKQDEGIINVPLARDQQSRARVAPSREGRSARTAYKVLKRDPSGLWSLVQVQIFTGRTHQIRVHFSHLNHPVLGDRIYGGTDWDRFGWKKRFLSRLAKRQLLHSSCLGIMHPVSRQWLEFISRPPRDFIRTLLWLVRKCQKVVVTGSAGCGKSSVLEYFRSLGFPVFSADKCVDDLYQPGSDGWLILRKRFGYRFTPQDDQPVDKKKLLAAVMQDSGLMDEIAHLIHPLVGHRLEEFWEKHADKRLALAEIPLWFESGMAGDRDCLSVGVFCPDFLRRNRVCSSRGWSPDVFESLDAMQFSQPEKIKRCQMVVDNSRDFQGLMDQVTALQRLLTGLRRKKAGVDYNHFKNMACNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUI0</accession>
    <name>D6SUI0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell wall polymerase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871653.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0274"/>
    <dbReference type="EnsemblBacteria" id="EFI32960">
        <property type="protein sequence ID" value="EFI32960"/>
        <property type="gene ID" value="Dthio_PD0274"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI32960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="369" mass="40498" checksum="A07A9BB341CD4542" modified="2010-08-10" version="1">MTSNKNAAKKQGPDLWLLFSVLILAGLGLMMILSTSAVMAERYYADKYFFFKRQLLFGLAGMLVMYLGCRINREVLYRLRYLWVAAALALLAVTVFTPWGYAAGGATRWVSLGFFNIQPLELAKVALVIYLACFFAFKQDKVKTFSVGFLPPTVITGLFCALLLLQPDFGGAVYMAGLLFLLSLVGGTRIIYLFSSSVLAGITAVVLVLQSPYRFRRWFSFLDPFQDAQDAGYQLVQSLYAFGSGGIWGMGLGEGRQKLFFLPEAHNDFIMAVVGEELGFIGVSLVFIVLGILLWRVLVICMSQSDLVDRFAGLGMGMIIILGALLNLAVVLGVIPPKGLPMPFISYGGSSLLVSFFCAGFLLNLSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJS8</accession>
    <name>D6SJS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869256.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3584"/>
    <dbReference type="EnsemblBacteria" id="EFI36131">
        <property type="protein sequence ID" value="EFI36131"/>
        <property type="gene ID" value="Dthio_PD3584"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="131"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="220" mass="24918" checksum="BFBA4EA963BF1E02" modified="2010-08-10" version="1">MEDTVETKDRIYEQLARVGKAISSPKRLELLDLLRQGPRSVEVLACESGLSVANASRHLQVLRQAQLVEVEKQGKQVIYSVGDQKVCEFFQTMCSLAEARLADFERLMRKVAENDPYLEEVDRSLLMQRAREGSITVLDVRPAQEYAAGHIPGAVSVPLNELEERIQEISPENKIVAYCRGPYCLLASRAVELLRSKGFEAVRIRDGVHEWKMHGLQLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJT7</accession>
    <name>D6SJT7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Restriction modification system DNA specificity domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869265.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3594"/>
    <dbReference type="EnsemblBacteria" id="EFI36140">
        <property type="protein sequence ID" value="EFI36140"/>
        <property type="gene ID" value="Dthio_PD3594"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="827072at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="195"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="382" mass="43541" checksum="F054978A55AD0922" modified="2010-08-10" version="1">MLSHFQQSPLEEIVNFKTGKLNSNAAKPDGKYPFFTCSQETYRTDTWSFDGEYVLLAGNNAAGVYPLKYFKGKFDVYQRTYAIRSINETKCLTRYVYYALRLQLELMKSISTGVATKFLTMSLLNRAQIPLPPLPIQRKIASILSAYDDLIENNLRRIKILEEMAQNLYREWFVKFRFPGHEKVRLVDSELGKIPEGWEAVKLGNLVKVRKGQNITKKTIVPGSIPVVAGGIKPAYYHNTANTQHPVVTISASGANAGFVSLYHEYVWASDCSVIDRSTTEHVYFFYLQLKERQHEVTRLQRGAAQPHVYPKDLMEIVAVEAPPHILNSFSAEVYPLLHMVRNLSLKNRILRQTRDLLLPRLISGELDVSELDINVPEEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJZ4</accession>
    <name>D6SJZ4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">Dthio_PD3653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869319.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3653"/>
    <dbReference type="EnsemblBacteria" id="EFI36197">
        <property type="protein sequence ID" value="EFI36197"/>
        <property type="gene ID" value="Dthio_PD3653"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="15673" checksum="CD698481C31AB4CD" modified="2010-08-10" version="1">MAFLFDTDAISELLRPRPAKAYAKWIMHVSREAQFTSAVVIGELYKGAYRSHDRERHISNIEQRVVPAVTVLPYDIGIAKVFGSIRAHLEDTGMILPDADIQIAATAIGHNLKLVTGNLRHFNRIPGLKLNPVFANSRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK23</accession>
    <name>D6SK23_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869348.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3683"/>
    <dbReference type="EnsemblBacteria" id="EFI36226">
        <property type="protein sequence ID" value="EFI36226"/>
        <property type="gene ID" value="Dthio_PD3683"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2071648at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="147" mass="16303" checksum="8911551E93299663" modified="2010-08-10" version="1">MHNMLPLQKVPQERQTGFTLVEALIAMLILVVGIVGWMAAQDASVSNRGLSRTMTVATELVQSKIEELAGNPEAYCNSSLCSENEEIAIGGLKYEIEWDMEKINECGSILADANPMWVIKVKASWEYRGKKTRNVRRVVGGEKEEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK64</accession>
    <name>D6SK64_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">Dthio_PD3730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869386.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3730"/>
    <dbReference type="EnsemblBacteria" id="EFI36267">
        <property type="protein sequence ID" value="EFI36267"/>
        <property type="gene ID" value="Dthio_PD3730"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="91"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="154" mass="17514" checksum="1E2C28478275389F" modified="2010-08-10" version="1">MDYQEIKKQVEELVQTNCRLMGLEPWGMDFVPGTGKQRGVLRVFVDSPEGVSIDQCADLSRQLSVALDVEDLVPGSYNLEVSSPGLNRRFFRPEQMSGYTGHKVKITLKEPRDGRKNFTGTLQEAENETISIQTSPDCTWSFQWDEIDRARLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK90</accession>
    <name>D6SK90_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mutS</name>
        <name evidence="13" type="ORF">Dthio_PD3756</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3756"/>
    <dbReference type="EnsemblBacteria" id="EFI36293">
        <property type="protein sequence ID" value="EFI36293"/>
        <property type="gene ID" value="Dthio_PD3756"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="12">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="829"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="608"/>
            <end position="615"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI36293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="877" mass="99618" checksum="1739D27DDA896975" modified="2010-08-10" version="1">MQIKQDYPDCLLFFRMGDFYELFFEDAETAARELQITLTARNPNAELKVPMCGVPYHACEEYLRQLLEKGHKVAVCDQVEDPGAAKGLVKREVTRVLTPGTVVEDSSLEARENNYLGALFWDTSRGRGGLAWAEFSTGEWTGLELKNEDELWQWLQKINPSEILVAQGYEPPRAHVGLQPRINFVPAGSYFEPRSAREMILRSQQAVSLQVLDLEDKPCLVRACGAILMYMVQTHKKELTHLASFKPMNLTRYLYLDEVTIRNLELFRTLGGQKGPGTLLHVLDRTLTPMGARYLQTRLRQPWKEPGPINDNQQTVDCLYKDNNLRELLRLELDQAYDLERLNTRIALNRCNPKDLAALLRSLQILPGIKKALQGMQDKPGLVNKTLENWDDMQDLCFTLEKALVENPPHLITEGGIFRSGYDSRLDELIELTDHGESKLKELLEKERTQNDLPKLKLGYNRVFGYYFELSRAVKDSVPEHFQRRQTLASSERYLTPELKDLENSMLSAAEQRKSREMDLFGELRQFVAGHGSRMKKMSACLARIDYWQGLASAAREWNWSRPVLSKDIGMQIKKGRHPAIEAIQGRSGYVPNDMYLEDPTRILLITGPNMAGKSTVLRQTAIIAILAQMGSFVPAREASIGLCDRIFSRVGASDNLAQGQSTFMVEMTETARILRQATRRSLVILDEIGRGTSTYDGLALAWAVVEELARKHEGIRTLFATHYHELTKLEQEFSVLKNYNIAVKEWKKEIVFLRRLVPGPADKSYGIEVARLAGVPDRVVDRARNILEDLERQKERKSVVREQRKTMFEQGMSMGPAQKVKEDVQSGQYTGDNDDKHGVKKGEEHPVVSRLAGLDINSMTPLEALNLLAELKKEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKE3</accession>
    <name>D6SKE3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869465.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3814"/>
    <dbReference type="EnsemblBacteria" id="EFI36346">
        <property type="protein sequence ID" value="EFI36346"/>
        <property type="gene ID" value="Dthio_PD3814"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1559099at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="353" mass="35979" checksum="6918A426C2110678" modified="2010-08-10" version="1">MILQNILSISLAAAPWLLLGLFTAGLIKALIPESTLQRWVGGSGPGAVARAALMGAPLPLCSCGAIPTALAMYRGGAGRGPTTAFLISTPGVGADSLAITYALLGPVMTLARALGAVVTGVVTGLLVSLVRPPCSIESAPAEAGEDGCSCSSTGTGCAGGSTIIPSEPLAVGIKAGMRYVFYDLFRDIIAWILLGLVIAGMLITFVPPQALADYGSGVWAMLVMAVAGMPMYICAAAATPISAGMLMAGVSPGTVLVFLLAVPITSLSTLGVLRREMGSRVLACYVAGIVLTTVLLGLGMDHLVVLAGIDMAVQKGAARDLLPVWLEWTGLVVLVLLTAVTVFKSKGGIFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKE8</accession>
    <name>D6SKE8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ORF">Dthio_PD3819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3819"/>
    <dbReference type="EnsemblBacteria" id="EFI36351">
        <property type="protein sequence ID" value="EFI36351"/>
        <property type="gene ID" value="Dthio_PD3819"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="183"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="189"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="236"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="301"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI36351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="442" mass="49149" checksum="3B862AC97D89BB46" modified="2010-08-10" version="1">MPGCRVFMLPFVVIVGRPNVGKSTLFNRLLRQNKAMVHDRPGVTRDSLYGRVQGRTRDYTLVDTGGLVLEQGAQLEEEIYEQVREAMHSADLILFMVDGSAGVTALDEQLAAMLRQSRRPVRLVVNKVDGEERAALVEGDFYSLGFDMNMVSAAHGYNMPVLQEAIESSLPAHEEPEDQAAHLRLSLLGRPNVGKSSLVNTLLGQERVLVSSRAGTTRDCVDVILEKGDKRYVFIDTAGVRRKTTISDDLERFSALRAIRSCQRSDVALLVLDALSGMVAQDKKLLSFLEREKIPLVIVVNKVDQIPRKDLGKLKRYFQDELAFCAHAPVIYTSCITRAGLGGLIPLAEKVLGQSRVRVGTGELNRLVRDAVQAHQPPLVKGRRAKIYYLTQPGTSPPEFVFFVNDPGLIKPAYARYLEKQIRKSLGLDVTPVKLFFRGSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKP2</accession>
    <name>D6SKP2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2664"/>
    <dbReference type="EnsemblBacteria" id="EFI35253">
        <property type="protein sequence ID" value="EFI35253"/>
        <property type="gene ID" value="Dthio_PD2664"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="548" mass="62128" checksum="4F1E4164398F1E29" modified="2010-08-10" version="1">MPEDVKVGDLLLSRGLIQNKHMEYALQVQKVTREKLGRILTRLGMVSEYDMVRAVAHQLQVPCVDLTRWKPEMQWLRRFNRNFCLQNRVLPLGVHKDQLVVATSEVPKVQVQQKIHRLSGKAPKFALTEEHQLVNFVYDHFFFMDRPVEELLHMEIQSLYADTGNTLSPDNFLHYLLLWAIKSQATDVHIRSMEQGISLAFRIDGVLHDRVFIPRELQRIITAIKLQAGMDISEQRLPQDGRWTARLLERSYDIRVSTLVTPYGENIVMRLLALGRMQFSLAGLGFLDKDLPLLRQAFQEPYGMILLTGPTGSGKSTTLVSGLSSIDLLEKNAITIENPVEHVIPLARQTQVNEAAGYDFSTAIRNFLRHDPDIILIGEMRDEITARTAMTASVTGHLVLSTLHSNTALGSIPRMLGLGIDHLTMSETLIAVVSQRLIRTVCSHCNQQYPLSREEKEYLERDTEYGSRGQGCDQCDHSGYKGRTVIYEILPVFGELRELIERGASKQELAGSVRSHGFRSIFDVAVDKVEAGFTDVAEVKRVLGRFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKZ2</accession>
    <name>D6SKZ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase of anthranilate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868485.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2768"/>
    <dbReference type="EnsemblBacteria" id="EFI35353">
        <property type="protein sequence ID" value="EFI35353"/>
        <property type="gene ID" value="Dthio_PD2768"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="190" mass="21533" checksum="8BE72A447985257B" modified="2010-08-10" version="1">MILLIDNFDSFTFNLVQVLQKLDVDPVVLRNNQEEIFDTLKQDLQAVIISPGPSRPENTGLCLDFLKKLSPEVPVLGVCLGHQVLGHFAGARVEVADRIMHGKTSKVYHRETGLFKDIPNPFEVCRYHSLLVRAVTDNAFRITARTKDDEVMGLEYTDRPWMGVQFHPESILTPWGPKVMQNFLELCGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL44</accession>
    <name>D6SL44_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868537.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2821"/>
    <dbReference type="EnsemblBacteria" id="EFI35405">
        <property type="protein sequence ID" value="EFI35405"/>
        <property type="gene ID" value="Dthio_PD2821"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="287" mass="31612" checksum="3D85106275AB6A52" modified="2010-08-10" version="1">MRLAIISGKGGTGKTTVAVNLALYLQKEGQKVCLADCDVEEPNAHFFLDAAWSRENRQTVAVPEIDNTKCLGESCLQCVNECRFNSLIWIADKVMVFPELCHACGLCFFLCPVQAVDESTREIGLVRHGKGRGVEVCGGLLRIGEAMAPPLIRRVLKSTPGQGIVIADAPPGTSCPVMETLRDVDYVILVGEPNPFGLHDFKIAVELVRKLGLALGTVINRDGMGDDQMEKYIRHERLPLLARLPYSRQAAAACSRAEPLLEAMPEFKEIYRNMWENLQKEMQAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLF3</accession>
    <name>D6SLF3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868646.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2938"/>
    <dbReference type="EnsemblBacteria" id="EFI35514">
        <property type="protein sequence ID" value="EFI35514"/>
        <property type="gene ID" value="Dthio_PD2938"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="174"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="388" mass="43911" checksum="50A8F5E69331DE42" modified="2010-08-10" version="1">MENVPRFFREPQYGFFLFGPRGTGKSTWLEQTMENAVWIDLLDPEAQRLYRARPERLHQVVAGNPAARDVVIDEIQKAPALLDVVHAMIESDRQLRFVLTGSSARKLRRGGFNLLAGRLMETFMHPFMAAELGSAFSLEHALRYGMVPLVTSAPDPAAVLRTYASLYLNEEVQAEALVRDIGAFSRFLEAISFSQGSILNLAQVARECQVGRKTAEGYLDILEDLLLCFRLPVFTRRAKRHLVRHAKFYFFDVGVYRSLRPSGPLDRPEEIEGPALEGLVAQNLRAWATYRQTPARLYYWRTKSGSEVDFVIYGPDTFWAVEVKRSGSIHSKDLRSLKTFCQDYPEARACLAYLGRERLMIDGILCIPCQEFLLGLDPAHQGLAGPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLF6</accession>
    <name>D6SLF6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868649.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2941"/>
    <dbReference type="EnsemblBacteria" id="EFI35517">
        <property type="protein sequence ID" value="EFI35517"/>
        <property type="gene ID" value="Dthio_PD2941"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="17769" checksum="13DB19010F861C96" modified="2010-08-10" version="1">MVYRLHYTQILPVDVNTAWDFFSQPANLCRITPDWLCFDIRFAPDEKMYPGMIIEYVIRAVAGIPMRWLTEITQVQKPYFFVDEQRLGPYRFWHHQHLLKEAQGGVEVTDLVHYSLYLGPLASPLHVLLVRPRLEEIFTFRRKALTEIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLS1</accession>
    <name>D6SLS1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MCP methyltransferase, CheR-type</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3061"/>
    <dbReference type="EnsemblBacteria" id="EFI35632">
        <property type="protein sequence ID" value="EFI35632"/>
        <property type="gene ID" value="Dthio_PD3061"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="272" mass="32082" checksum="4A25C33470CA5E2E" modified="2010-08-10" version="1">MTLASREIIFDEFLQRVCPPRDLDWRKYRRASRRNVLRRIYQLGLGGFSEYADYIDSHPLEAAFLPNLLNVTVSRFFREKELWDHLAADVLPAMAAAHPASRPLQVLHIGCCNGEEPYSMALLWKNEIEPVFLRTSISITALDIDQACLDRASKGWYPRKTLREVPVELQRKWFEPEMEGFRLHKRIRHMVNFTKLDLLKDHLPGKQDMVFCRYLVFTYFQGKRRREMARKISECINPEGLLILGRKESIEPQEQDLFTPVSQNLKIYKNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLZ3</accession>
    <name>D6SLZ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868833.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3133"/>
    <dbReference type="EnsemblBacteria" id="EFI35704">
        <property type="protein sequence ID" value="EFI35704"/>
        <property type="gene ID" value="Dthio_PD3133"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="270" mass="30927" checksum="7EA6B5B077D62034" modified="2010-08-10" version="1">MEEASESKLWNMIRRMFGTRCDAPLEEVIREASEEGEIKNEEVRMLLNILRLHEKQAVEIMVPRTDLVCAEENDTLKDVAESILQSGHSRLPVYRENKDHIVGLIHAKDLLQHFFENKDVSVNSLMREPHFMPETKNVRQILMDFQNQKIHLGVVLDEYGGTSGIVTLEDVLEEIVGEIEDEYDPPRPQEVQTMDDGTYYVAGRTSLDELADIGIKIPTEQVETIGGYISHLAGKVPVKGEEFSDEFFSYVVQEANTKNIQWLTIRRLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM23</accession>
    <name>D6SM23_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868863.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35734">
        <property type="protein sequence ID" value="EFI35734"/>
        <property type="gene ID" value="Dthio_PD3163"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033AAX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2044168at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="146" mass="17056" checksum="DABBDF1D3BE48F57" modified="2010-08-10" version="1">MVLTLLKISREAVQPVFDADEMRFCWKVNMQQYLDGQGRLDPFLPRSSFIMADYFGRIVWVATRDATFGPVFTEIGCRRRPHRYPCRGRLEIIYVDYLCNGQIYWRCSSCSDKGIIIGWEGSCWDMMAREPGHVLSRAEEKPGRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM27</accession>
    <name>D6SM27_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="4" type="ORF">Dthio_PD3167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868867.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3167"/>
    <dbReference type="EnsemblBacteria" id="EFI35738">
        <property type="protein sequence ID" value="EFI35738"/>
        <property type="gene ID" value="Dthio_PD3167"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2057189at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="75" mass="8680" checksum="CC7F98FCB60B764A" modified="2010-08-10" version="1">MPAKQGDFDKKMQRLQKIVQELEKKDLPLEKGVQLFKEGMEITRTCREQLEKARHEITVLAEDAQTPRGNDEQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM30</accession>
    <name>D6SM30_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phage shock protein C, PspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868870.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35741">
        <property type="protein sequence ID" value="EFI35741"/>
        <property type="gene ID" value="Dthio_PD3170"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="143" mass="16067" checksum="0840E75281D0F4B9" modified="2010-08-10" version="1">MITIQKNLQDALLAGVLAGLAHHWQVSRSLLRILFFLAFVLLNFMPFMGLWASMAPVLLYVLLWLAMPEPSGELTEKEQEEKAARTKTFYNYTMLGVVLNLAPFLFLALFNPDQLFILLLSVPALFLLLPATLFIITGIIKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM53</accession>
    <name>D6SM53_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3195"/>
    <dbReference type="EnsemblBacteria" id="EFI35764">
        <property type="protein sequence ID" value="EFI35764"/>
        <property type="gene ID" value="Dthio_PD3195"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="12"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="187"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="43591" checksum="1EE67845998EAC14" modified="2010-08-10" version="1">MFSRWLTIPSYKSCLLIGPRRSGKTTLLRGLFPDLNYTTLDDLDYLDWAERDPKGFVQDLGNSCIIDEIQRSPRLTIAVKHAIDQRDAKIFMTGSSSIGLLDAAADTMAGRIEILSLPALCWGEELGRPTHNVFIDEANHVQLKQGARMLDQAVTFGGFPEVAAQKNEEGKAKILIRYKNSYFTRDLMQLSNIENLQGLLGIMHNLVHCLGSHLEVSNFARESGVSHPTAKKYLNSLNQAQLTFQLRGYNFGPAKRYIKATKTYFADNGIIFSLRTQAGPGALLENFVISELEKRRKLGFIPTDEFCYYKSASGHEIDLIFETRDCLYAIEVKSTRHPGRSDITSLMNFKPKKNLKVKRFLFYLGEEYQTVEDVRLIPAAALFCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMM8</accession>
    <name>D6SMM8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869067.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3381"/>
    <dbReference type="EnsemblBacteria" id="EFI35939">
        <property type="protein sequence ID" value="EFI35939"/>
        <property type="gene ID" value="Dthio_PD3381"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="545" mass="60411" checksum="3D1FDFCC8B0B6CDA" modified="2010-08-10" version="1">MNFKRTLQALSLFAFITLLLLAAFPLRTWFPTDFFLRLDPLVFAGTVLGAREWAGALLPGLLIILATLFLGRFFCSCICPMGVTLDISDRIFRPRDSGRNLSVQSLLTLRRVKYLVLFFILGTAIVGVSSVFIASPLSLVTRFYGLVIYPFAVHVLDLGLDNLYMVYSGLGLQSLAYFEPQSYRFATQIFILAFFILVFSLVVLAPRFWCRSLCPAGALLAIFSRKPLLRRKVSTSCTECGLCQRRCPMQAIEEDPHRTSHQECIVCLECVRVCPEKAVSFQTGRSKEAADSGFLPQRRKVMASVLGGVGSALLLQTGIREVRSDTVPGNVTPQFLIRPPGALEEEDFLGRCIRCGQCMKACPTNTLQPVWFEAGVLGLFSPKALPRRGPCDPTCNVCGRVCPTGAIRDLPINERVWARMGTARVVRGKCLAWAWDRKCLVCFEVCPYAALELRRVPGIDIPVPFVVLEKCSGCGACEFHCPVQAQSAIVVEPMNSLRMNKGSYIEEGRAQGMVLDPDPDREREPPEEIMPDTEEPDDLPPGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMX9</accession>
    <name>D6SMX9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869168.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3483"/>
    <dbReference type="EnsemblBacteria" id="EFI36040">
        <property type="protein sequence ID" value="EFI36040"/>
        <property type="gene ID" value="Dthio_PD3483"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="13957" checksum="A737C8D35C92BD10" modified="2010-08-10" version="1">MHMKSKSQITTDAGRRLPRNRPPTHPGEMLFEEFVKPLRLTQVELARCLGVSYPRLNEIIKGKRSVTPDTALRLSRVLGMSPDFWLGLQQNWDLWHVMNSPEAENINRLKPIPRNQHFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMY5</accession>
    <name>D6SMY5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical cytosolic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869174.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3489"/>
    <dbReference type="EnsemblBacteria" id="EFI36046">
        <property type="protein sequence ID" value="EFI36046"/>
        <property type="gene ID" value="Dthio_PD3489"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025587">
        <property type="entry name" value="DUF4351"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14261">
        <property type="entry name" value="DUF4351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4351" evidence="1">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="334" mass="39093" checksum="7097CFAE7DA988F5" modified="2010-08-10" version="1">MSDEYDSPWKIALERYFPEFMEFYFPGIFADIDWSSGYDFLDKELQQVTKDAELGRRYVDKLVRVRRLSGDEGWVCVHIEVQGEAEDVFARRMFTYHYRLFDQYDKPLASLAVLADTSPGWHPDSFGYELYGCRLRFDFPAVKLLDWESEIDQLLESDNAFALVTAAHLLTKKTQGKPEERYAAKIRLIRILFARGWDRQRILDLFKVLDWLMSLPEDLESKIFNDIRQIEEEYQMPYVTSIERIALKKGMQEGIEKGMQQGMQQGMQQGMQQGMQQGMQKGEAQLLLRQLALKFGSVPEDKQRLIESADSQKLRQWSERILTAQSMDEVLNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN30</accession>
    <name>D6SN30_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869216.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36091">
        <property type="protein sequence ID" value="EFI36091"/>
        <property type="gene ID" value="Dthio_PD3538"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033INW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2129268at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="183" mass="21111" checksum="64959456861470CA" modified="2010-08-10" version="1">MFDVRVTVNGKSVHLGYDAVEDIMFSIPDKKRFNNIIKEFAMSPVPQVRMEVASRSAINKEIIDILLEDIQIDVLRNLVSNHRAQRMIPESTLLRLVRTHDFEILETIAENIDQFSMCDPGIIAENICRSENPKVRDLLAENEFVGKKVLEILIHDDDKEIAVKARITLKRLEEEEELDPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN40</accession>
    <name>D6SN40_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869226.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3549"/>
    <dbReference type="EnsemblBacteria" id="EFI36101">
        <property type="protein sequence ID" value="EFI36101"/>
        <property type="gene ID" value="Dthio_PD3549"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1692541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="164" mass="18733" checksum="115CB73E33C10489" modified="2010-08-10" version="1">MKLETGSYQALAGRLQMRIQDLDLVVQRIALLMTKAEETADDGYLDGVALNLHSFYTGMESCFEEIARTIDGALPSGSNWHQELLQQMSADLRDLRPAVIRRSTRDCLDEYRAFRHLVRNVYTFNLKPERLKYLASDAGTCFEDCKQDIESFLGFLRALSQQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN71</accession>
    <name>D6SN71_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IstB domain protein ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0165</name>
        <name evidence="3" type="ORF">Dthio_PD1547</name>
        <name evidence="4" type="ORF">Dthio_PD2143</name>
        <name evidence="5" type="ORF">Dthio_PD2203</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869526.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0165"/>
    <dbReference type="EnsemblBacteria" id="EFI32858">
        <property type="protein sequence ID" value="EFI32858"/>
        <property type="gene ID" value="Dthio_PD0165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34197">
        <property type="protein sequence ID" value="EFI34197"/>
        <property type="gene ID" value="Dthio_PD1547"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34767">
        <property type="protein sequence ID" value="EFI34767"/>
        <property type="gene ID" value="Dthio_PD2143"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34818">
        <property type="protein sequence ID" value="EFI34818"/>
        <property type="gene ID" value="Dthio_PD2203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="98"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="251" mass="29112" checksum="774A000172736E12" modified="2010-08-10" version="1">MLNHPTLEKLQTMRLTGMLKALQEQQETREIEALSFEERLGLLLDREMTERESKRLQTRLKKAKLRHRAVVEDINYRHPRRLDKSQVFKLCDCQWIKEHQNLIITGPTGIGKSWLACALAQKACREGYSALYTRMPRLLQDVGISRGDGRYPKVMKELAKTDLLVLDDWGISPLKAEQLRDLLEILEDRHGLRSTLVTSQLSIQKWHEYLGDPTLADAVLDRLIHNAHRMDLWGDSMRELEASLTSKNSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN98</accession>
    <name>D6SN98_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869552.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1575"/>
    <dbReference type="EnsemblBacteria" id="EFI34224">
        <property type="protein sequence ID" value="EFI34224"/>
        <property type="gene ID" value="Dthio_PD1575"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1626243at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="246" mass="28889" checksum="E80658B3D94659CD" modified="2010-08-10" version="1">MYSPLIIFTHIPRAGGTSMWKTFRRVYGKRVKRIKGHGLLKTREITAQILKESPHDYDVVGGHVRYGVGENCTDRPYQYFTVLRDPTHALLSRYYKLLQPEVQERKAKRDPGDYEDNLRKIKKIVSSPEELLQNSNHLLLRFILGIDEDNETQVTRDHLELAKIRLKHEYVCFGLVERYQESMELISRSLRWEAIPMAEQCNTGGNRPDVHDPKLIELGRQVNALDYELYSYAEQLFSERLRQIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SND1</accession>
    <name>D6SND1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869585.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1608"/>
    <dbReference type="EnsemblBacteria" id="EFI34257">
        <property type="protein sequence ID" value="EFI34257"/>
        <property type="gene ID" value="Dthio_PD1608"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="146" mass="16360" checksum="E353C0E5FF824F8A" modified="2010-08-10" version="1">MPEIKRMLLPVVFSENDMLAADYARQIAMCAGSEVDLVHVTPQIDFISEDILQSVYTSHVGYEKEVAEKLMDAFIEKSLSGVNVRNKAVLKGQPAEEVLRYAKENNINMIVLPTHTRKGPEAWFVGSVAERITKRAHCPVLIVHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SND4</accession>
    <name>D6SND4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869588.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1611"/>
    <dbReference type="EnsemblBacteria" id="EFI34260">
        <property type="protein sequence ID" value="EFI34260"/>
        <property type="gene ID" value="Dthio_PD1611"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1121024at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="364" mass="41891" checksum="3EA5B7388D02BB0D" modified="2010-08-10" version="1">MKRVFEGPAKTSGKKQVTIEGPIAGNRWTWVVESGFYSMGLESAIHFHDCPEPMSRISNRMHHLMRKFGLPGTFVEWETMSNHRLRDMVKKNKTPLVVSLQGLIDRQTVENIRELNPIIRIIYWWGPPVRREDQIDRIMEVDELVDVVALSFNKDLENLRSMGARNVVHLPFAACPYHHRLKVKVTSGSRRKYGRDVMLISPYGEYEEELVRRVSETLGQKVDVWGPGWSDNEWVRANGLIFPPRNLEAYASSTIVINTHGEDFARHDGLNPAFFEIPAAGGFQITEKQAVVDRQDFGRHVATFQDSRELAEKVRYYLHDQGARESMRSALQAHILEHETYGRRLYNLLEYMDSVQAQSQAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNE5</accession>
    <name>D6SNE5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-viologen-reducing hydrogenase delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HdrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869599.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1622"/>
    <dbReference type="EnsemblBacteria" id="EFI34271">
        <property type="protein sequence ID" value="EFI34271"/>
        <property type="gene ID" value="Dthio_PD1622"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003813">
        <property type="entry name" value="MvhD/FlpD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02662">
        <property type="entry name" value="FlpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="727" mass="80319" checksum="D452F162A7A1CB0F" modified="2010-08-10" version="1">MADNKTGVYICTGCEIGDNLNKEAVREYIDEECSPAVLKEHGFLCSKEGVAEIQNDIDNEGVNKVCIGACSPRVMWDVFDFGPSVLVERANIRELAVWSFRDPELPEPEDDEMSDPLTMMVRDYIRMGVVRLEKTDYPEREPLEPSNTIMVLGGGVTGLNAALGAANTGYDVVLVEKEDKLGGFAAKMYKQTPTKHPYTEAEQPSVDELIRKVEGNDKIKVLTKAELQLIKGAPGKYTVTVKSGGEEHELFIGSVVLATGWKPYDASKLGHLGYGKIKNVVTNVELETMAKEGKLQRPSDGQPVKSAAFIQCAGQRDPEHLPYCSSVCCMGSLKQAGYIREKDDDAKAFIFYKDMRTPGVFENYYRAAQDDPGIFLTKSEIQEVSEDGDGKVVVKVTDTLLGEDVEVAVDLLVLATGMLPTIAEDAVLKLGYRQGEQIPDLELFNGFADSNYICFPYETRRTGIYAAGCVRQPMSMGTAKDDAAGAALKSIQCLESVNHGVAVHPRSGDPTYPKFNMVRCTQCKRCTEECPFGALDDDEKGTPEPNTTRCRRCGTCMGACPERVISFDNYSVSMLNEAIGAIQVPEDEEEGGYRILCLVCENDAYPALDMAAMRKNKWSASIRFIGIRCLGSVNTQWIAESMSKGIDGVLLLGCKYGDDYQCHFIKGSELCNMRMDNIGETLERLQVESERVQQKQISIDEYDKIPKIIDDFIEEIEGYGPNPYKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNI8</accession>
    <name>D6SNI8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869642.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1665"/>
    <dbReference type="EnsemblBacteria" id="EFI34314">
        <property type="protein sequence ID" value="EFI34314"/>
        <property type="gene ID" value="Dthio_PD1665"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="337" mass="37413" checksum="AF7DD1F7A1C7BA65" modified="2010-08-10" version="1">MSLYVLRDVQQIFEGRTVLDLPELVLEAGQSYALLGPNGSGKTTLLHILAMLNAPAKGRVFYKGQEINWKANYLTPIRRELVLVDQHPIMFSTTVAKNVEYGLKVRRINSAKRRQTAMESLERVGMQDFAHRPAHQLSGGETQRVAIARAMACSPQVMLFDEPTASVDVENQAVIEKIIESIRKEREITVIFSTHKRLEASRLAEHRVFLFEGRLTGPGGENIVPGYVAMKDGKKVCVVREKLELQVESNIDGPCRIQVHPEKIGIYNKDQGIDSEQVVPGRVLQMTDEGGQIRVLLDIGFPIRSLMSREAIARSGILVGDEVCVGFEAGAADVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNI9</accession>
    <name>D6SNI9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869643.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1666"/>
    <dbReference type="EnsemblBacteria" id="EFI34315">
        <property type="protein sequence ID" value="EFI34315"/>
        <property type="gene ID" value="Dthio_PD1666"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1110665at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="234" mass="25611" checksum="682B95588FEA545A" modified="2010-08-10" version="1">MEGFLISSLAEAVRMLWSLDPELYFIVYVSLYVSFFSTLIAAVLGIPLGFLVAVKEFRGKRAVITILNTLLALPTVVIGIFVYAFLSRRGILGDLGMLYTPWAIVVGQVILITPWVTTFTLAAVSRIDSRYRRTAMTLGANLWQTSLSIAREARYGILAAIIAAFGRAIAEIGIAMMLGGNIKGFTRTMTTAMALEHNKGEFILALGLGIVLLSISLFMNIFMQLVQGRYGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNK0</accession>
    <name>D6SNK0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4168 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869654.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1677"/>
    <dbReference type="EnsemblBacteria" id="EFI34326">
        <property type="protein sequence ID" value="EFI34326"/>
        <property type="gene ID" value="Dthio_PD1677"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031CUR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1998733at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025433">
        <property type="entry name" value="DUF4168"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13767">
        <property type="entry name" value="DUF4168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4168" evidence="2">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17504" checksum="C64643A9A80BB62D" modified="2010-08-10" version="1">MYQKTGLKVFGLAVVIMFVLGMAFKVGAQQEYQPDQQQQQQQQEYQPDQQQQQEMMQQEAPEVDLSDAELDKVAEAYEAVTEVREEFQADLEGIEDPEQAQQMQEEAGEKMVEAVEDQGLEVETYNQAMEAAQVDEELRNDLLDRLDMEQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNN4</accession>
    <name>D6SNN4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formate dehydrogenase, beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869688.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1711"/>
    <dbReference type="EnsemblBacteria" id="EFI34360">
        <property type="protein sequence ID" value="EFI34360"/>
        <property type="gene ID" value="Dthio_PD1711"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015944">
        <property type="term" value="P:formate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014603">
        <property type="entry name" value="Formate_DH_Fe-S_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036298">
        <property type="entry name" value="FDH_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="27701" checksum="1E6C717409D9E9CA" modified="2010-08-10" version="1">MDGKGFFIDLTKCTACRGCQVACKQWHKLPAEDTRNWGSYQNPKDLSFITYKLVRMEEAVENGKIKDWLFFPDQCRHCIEPPCKMVADMDDQQAVLHDDRTGAVLFTSRTKNLYPDEIKGSCPYDIPRADQESGLISKCDMCFDRVMNDRLPACVLACPTGTMHFGDMDEMKELAEKRLEEVKKIYPEAVLGDPRSVRVIYLFQTSPSKFYHSAVASLHGPRRFTRKEAFARVFKNRRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNP8</accession>
    <name>D6SNP8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1726"/>
    <dbReference type="EnsemblBacteria" id="EFI34374">
        <property type="protein sequence ID" value="EFI34374"/>
        <property type="gene ID" value="Dthio_PD1726"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="193"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="408" mass="45165" checksum="8B4093B544B99562" modified="2010-08-10" version="1">MPRVLESLTDTPVVLIHGPRQCGKTTLARLVGDARGFTYLSFDDDVQRSAAQFDPVGYVADLPEQVILDEVQRVPELFTSLKAVVDERRKPGRFILTGSAHVLMVPRLADSLAGRMAILRLHPLSRAEIAGKPAAFLNALFGRGFRIGVFGRRQGRVLAEHITAGGYPAALSRTTARRRTAWYRDYIDTLVQRDVLDLTRISRLDVMPRLLEMAAGQTARLINVSDMASPFQVSRPTIREYLTLLSRIFLLEELPPWHSNRLSRLIKTPKLHLGDPGLACALLGVDAGSLWQDRALFGQLLETFILQELRRQAGWQEDDISFSHFRDKDNNEVDMVLESGGKLAGIEVKAGSTVTSSDFNGLQKLQRAAEKSFTAGVVLYDGDSVVPFGKDLYAVPISCLWGGSGFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNQ4</accession>
    <name>D6SNQ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1732"/>
    <dbReference type="EnsemblBacteria" id="EFI34380">
        <property type="protein sequence ID" value="EFI34380"/>
        <property type="gene ID" value="Dthio_PD1732"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032U1G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020994">
        <property type="entry name" value="Uncharacterised_Ca-bd_CcbP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11535">
        <property type="entry name" value="Calci_bind_CcbP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15359" checksum="77B8E83588F89C41" modified="2010-08-10" version="1">MGTGSSGTHLSQKMRCFKHKMMLKWVLECLSPAFLKSAKQIHAFDAWERHLEEVLKLPFEAVVSEFQEKGLLQQVDKVKVHGFEGWDNLYGIIVSIRAGRRKYAVPLCDLEVIDRTSSNYQPVKDYAVWFANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNT1</accession>
    <name>D6SNT1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module killer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869730.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1765"/>
    <dbReference type="EnsemblBacteria" id="EFI34407">
        <property type="protein sequence ID" value="EFI34407"/>
        <property type="gene ID" value="Dthio_PD1765"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014056">
        <property type="entry name" value="Addiction_killer_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41791">
        <property type="entry name" value="PTHR41791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028744">
        <property type="entry name" value="Addict_mod_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02683">
        <property type="entry name" value="upstrm_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10627" checksum="8019B8A624BE07D2" modified="2010-08-10" version="1">MEVRKTEVYVKWLDGLRDIRARARVLARVERLAAGNPGDAAPVGEGVSELRINYGPGYRVYYKQQGRELVILLAGGDKSSQSRDIKTAQRLARNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNW1</accession>
    <name>D6SNW1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1796"/>
    <dbReference type="EnsemblBacteria" id="EFI34437">
        <property type="protein sequence ID" value="EFI34437"/>
        <property type="gene ID" value="Dthio_PD1796"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="7">
        <location>
            <begin position="63"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="344" mass="39418" checksum="238470931EA3A5F1" modified="2010-08-10" version="1">MNWDWEKLQQRNRQRKSGWEPGSGGGGPTPPDFTKIKEALNKWGDSRLILIILVIIMVGWLLTGFFRVEPGQVGVVQRFGAVVHVTEMGAGLNWHWPRPVGQATKVDTQQIRSFEIGFTRVEGRKRVNRDEALMLTKDKNIVHFEIIVHYQVQNPEEYLFEIENPEEVIKTTTESALRSAVGTLEIDRAIVAEGLSRIANNTQDLLQDLLDDYNSGLRVVNVRTERGDAPQEVRQAFHDVVRAMEDKERLIHRAEEYREDIIPRARGARAQRILEAQGEVKRFGQLLVEYRKAKGVTRQRLYLETIGDILPGVNKIIMDKDAAERVMLFPDGKGVRFETIETER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNW6</accession>
    <name>D6SNW6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869764.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1801"/>
    <dbReference type="EnsemblBacteria" id="EFI34442">
        <property type="protein sequence ID" value="EFI34442"/>
        <property type="gene ID" value="Dthio_PD1801"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBRA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1469405at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="283" mass="32061" checksum="E9C3CFBFCC863F5A" modified="2010-08-10" version="1">MHKVYEVINDLYDALHYVWEHDRTRQTITTVLIGTFLVTLTLTELNRFGMLPDNLGERLPTNPFYSVKLAFTLLLVNELISLIFILPCSVSRAVGKQLEILCLIFLRNAFKELSYFTEPIVLVGQLDAVLRIGANALGAVIIFVLLHFYYRQYVKRSGKGSRGERVYRFISVKKLVSMILLLIFTILGIYHLSFMWMHGEGIPFFAEIYTILVFSDVLLVLVVNRFFPGFNDIFRNSGFAVSTLLMRLSLTAPAFLNVVIGIGAALFALLLAMAYKRSTSGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNZ0</accession>
    <name>D6SNZ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin-binding A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869788.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1825"/>
    <dbReference type="EnsemblBacteria" id="EFI34466">
        <property type="protein sequence ID" value="EFI34466"/>
        <property type="gene ID" value="Dthio_PD1825"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="713667at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="3">
        <location>
            <begin position="370"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="498" mass="56867" checksum="A457B6035BAA7428" modified="2010-08-10" version="1">MEANFFRFAVQELFDKVQGVRIEKVYMPGRDIYTLDMGKRGNLILACSRKQGFFTLSSTKPPNPSKPPAQAMRLRKHIKNRRILDMISMWPERRIFLRLFAADPVWLELDLVRGLSVVDDPGVSPEDSIAWPDLESFFADKEIWKTHPQLTPPLRQELTRRSPDEAGRLLQDLAAGRPEGFFICEKGPDRLGLSCFRITDSDTCREFDSALEACAAFAEPGLQSLLDAPIEKAREKEEKKKNRKLQKKMQQIQEDHKRLLEMTKLEDQGKIIQNNLYQLDPEQKTAGLRLKDHHGLEHELELDPGRTVRENMQWFFKRARKGKRGLEAVSRRKNELAGPELGSHQADASRQEKESRQAQSSDSRSDLHRKAHVFRSSDGYTILRAKNSRVAGDLLRKYASWFDYWLHSQDGPGAHTILKRRGREESVPERTLEEAAVLAALASFQKNEGRARIMCALVKDVKPVKGAAPGRVKVDRVYKSLVVEPDPDLEAGLKVDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNZ6</accession>
    <name>D6SNZ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869794.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1831"/>
    <dbReference type="EnsemblBacteria" id="EFI34472">
        <property type="protein sequence ID" value="EFI34472"/>
        <property type="gene ID" value="Dthio_PD1831"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191938at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="861" mass="98700" checksum="FB50D16FB7E58640" modified="2010-08-10" version="1">MYNLSQLTGKLTEPAKTEMVAQGYAAWMTWSQELPDSIPETLQSFGGWEVAREGQQSLWMFPSQDVLHACAQVYRWYLNAGVQVHIRVFTAKLNFGPDMSYSLGLEERIRSLSVEYPRDLEIWVHAKVKENIEPRPGIKLEQAASSFLPEEKQWYYFRATEQAVFTSSFSWLFIVRPAALESEAEQDEAWNRQKTVLQEMCARMGFETFAGHRDHFVVRVDGIRQLKNWSLELLAIFSGRDKHLSCYLLGLDNPGINPAEGIPDRLMPDLKQMEPDCLYLPLKNILQMGRALEILPDARSSQDKKISDLFRAGLGPAYKEELQARLPVCLPAGLTRGGFTTCFYCGQKNHAPGDCPTRQIFNLDYALEQLARVDVHEINQALESLGSEVSSSVSWDELLRGSSPSRLVMRAIMGINYPAQHRTFRLMRRSRGREWPDGLKQLTDPQEDSRWGVMENLRMKQTGFVRNSLNRLCLKHPKDFRPRTMLGFLALEENDFKAARGYWEEAARLGYTPMQQAYHHYLLARLAETGQDFSRAFSLYQQAQKNSPGMLEARYRQGVCLVKNGDVDQAMSIFLELCRDTPEIFNQVLIDPELAQGHQHLMISLYSSWRERRKKARSAEETLQNLNRKARAWFPECHPLHDGFQTRIQGLEGLTSKENYAAFVRMEQGVKELQRDLEKAVGKEVQEVKKRFAKLESDLKDITSRLEAIPLKSIAAGKVYRLLNESRSLLENVRGLNTSTPHGYRQARDELDQAGKCAQLMQKRLRSLRLFRDGVLFLYFMTRSFFWILLGVLLASTLIVGLGTYVGLRREMDWAFSVLEQRQALMQAGVLLVAMLSLALAAIRTTMVFERLKSRYLEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP34</accession>
    <name>D6SP34_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidinol dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869832.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1869"/>
    <dbReference type="EnsemblBacteria" id="EFI34510">
        <property type="protein sequence ID" value="EFI34510"/>
        <property type="gene ID" value="Dthio_PD1869"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="1 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="436" mass="47799" checksum="07A8C921B48C55D0" modified="2010-08-10" version="1">MELVKKAKKSLAYGNSRIREAVTFLLDDIRTRGEPAVREMAAKYDGWSTDFVLQEEKKERLIAMVPEQVKTDIRFAHDQVFNFARMQRQSIQDFEVRPHPGVRLGQRVLPVDVAGCYVPGGRFAHACSAIMSVATAKAAGVPFVVACSPPREESIAPAVAFAMDLAGADVILELGGVQGVAAMAYGYFTNRPADILVGPGNAYVAEAKALLAGDGTCGIDVYAGPTESAIIADRSADPMTIAIDLVSQAEHGPDSPVWLFTDCRDLAYQVLNLVPRVIADMPDPHVPKTAWADFGEIILCNNRDEICRVCDTYAPEHVQILAADPDWWLESLRSYGSLFLGEGSSVAHGDKCSGTNHILPTRKAAQHSGGLSVHKFLKISTYQEIDTEASKRFSAVASRLSRVEGMEGHARSCDWRLTKFFPRENWDFQVFKNHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP68</accession>
    <name>D6SP68_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, delta prime subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1916"/>
    <dbReference type="EnsemblBacteria" id="EFI34544">
        <property type="protein sequence ID" value="EFI34544"/>
        <property type="gene ID" value="Dthio_PD1916"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="277" mass="30800" checksum="8D336B297312C1D4" modified="2010-08-10" version="1">MTMSSAPSTAIQEQSNAAGLLLRLVDNPPCSLVLEGGSQTQRSALAGYLLKALHCRNPGDGPCLKCDMCVKIEADAFRDLFRLTPLEGLSVDEVREIRPALSQSPHHGWRMVVVEEAGEMNASCANALLKSVEEPVSRNIFVFLSNERQSILPTIVSRSFVLTLGRTPGTGLESGQEELYSDFSTFVLHGKGFMHKCSKKENFDLTGARQFLVRIRLDLARGMRGEKSLFKNIEPVKANKMLLTLQKAEQALAFKARTDLVMQWLALTMWKIFNKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP95</accession>
    <name>D6SP95_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ORF">Dthio_PD1943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869891.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1943"/>
    <dbReference type="EnsemblBacteria" id="EFI34571">
        <property type="protein sequence ID" value="EFI34571"/>
        <property type="gene ID" value="Dthio_PD1943"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="284"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="459"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="607" mass="67302" checksum="8BE90325F7AC62AF" modified="2010-08-10" version="1">MCGIIAYTGHRPAVPVIIQGLKSLEYRGYDSAGLCFGHSGRLHLFRAAGKLNALEQKLEGGRVLHATSGIGHTRWATHGLPNETNAHPHLDVHYNLALVHNGIIENYQELKSMLQDCGCTFRSQTDTEVLVCLISHALEQHDSILNALAWSMSQVRGSYAFALLSKDHEGRIWAARKASPLILGAGTGENFVASDIPAFLPFTRDVVFLEDDELVEMDAGQWSVYHARTLNPVSKKIQRINWDVQAAQKGGYRHFMLKEIFEQPQVITDCLAGRMDRKHNRVTLTELEALPTPSRLHIMACGTSYHAGLWGKYVLESLARIPVNVEIASEFRYKELVEEPGTLYLSISQSGETADTLAGQRMVRQKGLPVLGLCNVVGSSVAREADSVLYTQAGPEISVASTKAMCSQLVMLYLLGLYWGQNRGTLSAREMSQNLLTLETLPQTLTSQLPDMQKRARQLCPEYSRARSFFFLGRGIYYPLALEGALKLKEISYIHAQGYPAGELKHGPIALIEQELPTFALAMQNHLLDKIGSNLMEVRARNGKIIALTNPGVELDIDEKWEIPQLGDPLNSFLALPALQLFAYEMAVYLGKDVDQPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPH0</accession>
    <name>D6SPH0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869966.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2018"/>
    <dbReference type="EnsemblBacteria" id="EFI34646">
        <property type="protein sequence ID" value="EFI34646"/>
        <property type="gene ID" value="Dthio_PD2018"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="286"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="503" mass="56466" checksum="E159E339C58F0913" modified="2010-08-10" version="1">MHQHNPGSLSQDQQDLIRFYQDTIEQAPIGIFTVTPDGRYLTANTTLARMHGFNTSEELITEVNDIASQVYVYPEEREEFKRVLESRGEVKNYESLFRRPDGSMFWVSRNVRAVRDEKGDVIYYQGFVTDITAKKDAEVRLQERVKEQQCLYQISSAFKKDTTLDTFLQQAVEAIPPGWQYPEDTAARITFGGKVFSTPGFQETPWQMSVEFTTGAQTLGDITVAYLQEKPRADHGPFLQEEWRLLHAIARHLGGITGRVLAEQEINRKNEQLQQLLDEKDRFFSIIAHDLRSPLTGVMGFTRMLAEEVDQFSQQDLREVAEEMHKATENLQDLLENLLQWASIQKGAIECEPEDVSLAGAADKSIRMVKTPAGNKDISIESEVDSGLMVYADRRMLDTVIRNLLSNAVKFTPAGGRIRISAEIENSECSVHVEDTGTGMDEQTLSGLFVLDRTTSRKGTGGEKGTGLGLLLCKEFVEMQGGKIRVNSTPGKGSTFSFTVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPI3</accession>
    <name>D6SPI3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869979.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2031"/>
    <dbReference type="EnsemblBacteria" id="EFI34659">
        <property type="protein sequence ID" value="EFI34659"/>
        <property type="gene ID" value="Dthio_PD2031"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1812319at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="19105" checksum="9B3E152F2C1C2E6F" modified="2010-08-10" version="1">MHKVISRVRVECVQGDIASQEDITAVVNAANSQLRPGGGVAGALHQKAGPGLEEECRPLAPIRPGEAVLTGGHNLPNRYVIHCLGPVYGVDRPEDELLARCYKRALSLAEEHHVDSIAFPAISSGAFGFPLDKAAQVALKTIADAATGLRQVKKIRFVLFSQEQKQVFEQALSSIEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPK1</accession>
    <name>D6SPK1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869997.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2049"/>
    <dbReference type="EnsemblBacteria" id="EFI34677">
        <property type="protein sequence ID" value="EFI34677"/>
        <property type="gene ID" value="Dthio_PD2049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021793">
        <property type="entry name" value="Oprl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11839">
        <property type="entry name" value="Alanine_zipper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087908" evidence="2">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="110" mass="12289" checksum="F22E4FD6449019B6" modified="2010-08-10" version="1">MFRKFLIPLFCMLCLVGLTFMGGCATKSQLEEVRTQAEQAETRADEAHTRADEAWNKADEAEVKAGEAVGIAEECCKDLDAMLQEVKDAAERAEQAAEKSERIFDKMLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPQ9</accession>
    <name>D6SPQ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Xanthine/uracil/vitamin C permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2108"/>
    <dbReference type="EnsemblBacteria" id="EFI34735">
        <property type="protein sequence ID" value="EFI34735"/>
        <property type="gene ID" value="Dthio_PD2108"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="586" mass="63268" checksum="3F6E82CB0E06DC8B" modified="2010-08-10" version="1">MQNNKSSTFKDMKKRSRAPGHLLYAVDEHPPWWMSALLGLQLVLLIVGPITITPVVVARVAEIDPGQFSWIIFASLVASGIGTFVQVRRVGKIGAGYLLFIGSSGAFIACSLAAAEVGGMSLVATMAVLSAPLQILFGLFLGPLRRIITPLVGGVIIMLIVVSVLGIALDLMSGQQEDVPQSYYLLVSVGTLVFILLLAVFGNRVVRLWSLVLGIFAGTLMASFLGMTDFSGLAGESWAGLPSGSWPGFSLVPAPEFLSIYLAFALVTIVGGVETLGDSMAIQKISQRNFRKIDYERVQGAIYADGTANAIAGALGTIPNTTYSNAIPAVELTGVSARRVGYCAALILVLLAFSPKMAALIAAIPSPVIGAFLFVLLSMLFVTGIKLAASHGLNYESGIIIGVSFWTGYAFENQFFFPDMIPEAAEPFMANGMAMGGLAAILLSLLFHLRPAGQASFVVERNVRDFTRLQNFINEYASARKIAPYQLQKLHLTAEELFAYLCASEEFKAPRMQVNLRRENRKIYVEFIDSSSARDLDFALEALEEKDGEVDPAELGLLLLGKYAENIRHIKIGGINYISFELPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ01</accession>
    <name>D6SQ01_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870141.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2217"/>
    <dbReference type="EnsemblBacteria" id="EFI34827">
        <property type="protein sequence ID" value="EFI34827"/>
        <property type="gene ID" value="Dthio_PD2217"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2050948at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="173" mass="19474" checksum="ECF5B0C18E061186" modified="2010-08-10" version="1">MRLGSYVASAVSELNKNDIFAGKTNIQKVVYFALPAELRKEFYRPYHYGPYCAEVQQAVSALLKREILSKSGKGFSLADNRTLNQETDPVIDRIKVTIDFFYKNSLTGADDIATLAKAHLLSRSEREDAKQNPVAYIQSQAKFLGWKELSGEDPEKIQAYLHLANNLDKALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ11</accession>
    <name>D6SQ11_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870151.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2228"/>
    <dbReference type="EnsemblBacteria" id="EFI34837">
        <property type="protein sequence ID" value="EFI34837"/>
        <property type="gene ID" value="Dthio_PD2228"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="273"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="519" mass="58831" checksum="0DDEC2ACEABE7FA5" modified="2010-08-10" version="1">MLELLRIKNLALIQDMELEFDPGLNVLTGESGAGKSFILKALDFILGEKMSASMVRAGEDKAVVEAVFVLDGEEYIIKRELAARTSRSRFYLNDSLSSQDRIQSLRDSLLIYTSQHGQQKLLKPAYHVRILDGFLENPGVLQKKDELLESMNQVLDRKKEIQGRLAELEEKKELLEYQKARIDEVHPEAGEEDDLLARRDEIKSRADLAQDVQKGLDILHSPQGSLLDGIRQLCRIAERMEALDEGYARQAGELENAAAALEDFDRVLRSTRVHDEEAELEKVESRLWELNQLKRKLGRSLDEILDMEREIQEHLSFLDQGRLDLKQLERQEAGLARELDQAAGELNQERRKCAGELASRLEKELQCLGFSEHIRVEFQFSPVEIYPGINEDRPRLLWIPNPGQPAQPLDKIASGGELSRFLLALVGLRSEKGMPTLLFDEVDAGIGGGTLIQVGQRIQELSRNRQILLITHWPQLADLADCHFMVQKEVYSDQTYTLCSRLDAEQSRSELARMAGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ42</accession>
    <name>D6SQ42_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870182.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2259"/>
    <dbReference type="EnsemblBacteria" id="EFI34868">
        <property type="protein sequence ID" value="EFI34868"/>
        <property type="gene ID" value="Dthio_PD2259"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="138"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="265" mass="30136" checksum="2963F9ED2C452206" modified="2010-08-10" version="1">MFKKILHPVDLNESLTEIKIRASFLYKMKAEDMVFFHVLNPGLGGHKHAESRLRHFQSALDEVGINVHYKVEEGHVASEITREAREQGADLIYIPARGRNFLMSSLLGSTTQDVVRLADSPVWVHKKRPDLRHEEQMHRIVFATDFQQAAEKCCQPVFFLGELVPELVVLHVGERAADPYSEQLRREHVNAKLEELKEQYSGYYRKVRQISRIGSPASHILDVVDEIQADAVILGRLNEPFPLHVMGSTCARVVSRVNSSVLLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ75</accession>
    <name>D6SQ75_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferric uptake regulation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur</name>
        <name evidence="4" type="ORF">Dthio_PD2292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870215.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2292"/>
    <dbReference type="EnsemblBacteria" id="EFI34901">
        <property type="protein sequence ID" value="EFI34901"/>
        <property type="gene ID" value="Dthio_PD2292"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14514" checksum="1B2CDF383CB60558" modified="2010-08-10" version="1">MRLTKQRKIILERLKQSRSHPTAVQIYDEVRSELPNISLGTVYRNLDILSKEGMISKIETCGDQKRFDGIPDPHLHIICSRCGKVQDAPQEPDLDLDQLTRVETDFLITGVRLELLGVCPDCNRENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQA3</accession>
    <name>D6SQA3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870243.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34929">
        <property type="protein sequence ID" value="EFI34929"/>
        <property type="gene ID" value="Dthio_PD2320"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1652403at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="314" mass="35674" checksum="7C085B6D9152199F" modified="2010-08-10" version="1">MQPLLNSLHNQHPIIPIIYLMNITSELDSYLISDDIMAAAYSGTTLKQRAWMKKQTAHLCTHYGLDGHHYTRSLQHRASDFSRTSMTRPVDYAGLVIDSFPPAWNKLLALLVPAAMQGSTETGVFVLSDNPEAINPELLTALELAGIEDIYCLDLDTLKDWLSRQGQDLECLFFACSQDFNVPDKGNHPFNRRRWLHLTGQETYRSAVWADKNHDWDWDVLAWANPDVYFLAAGEKAGQAPQGFEILDVEPGELKDMDVDVFFGPEEYFKDTRAPLGLSPGLEACWVWPGLDRHFFSSRREFWAGMPAHRNNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQB1</accession>
    <name>D6SQB1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870251.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2329"/>
    <dbReference type="EnsemblBacteria" id="EFI34937">
        <property type="protein sequence ID" value="EFI34937"/>
        <property type="gene ID" value="Dthio_PD2329"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="151" mass="17182" checksum="24BA2FE120513F4F" modified="2010-08-10" version="1">MKQPRPAFDCKICGQCCQGSGGIVATLAEQQKIADYLEMDLLEFQKIHVQRKGDKFFIRNNDHGWCIFFESGKGCAVHPVKPRTCRAWPFFRGNLMDESSFEMAKDFCPGIDPDADFQEFVRQGMMYLQEQGLGRELEDDAGNALRTSDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQB3</accession>
    <name>D6SQB3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2331"/>
    <dbReference type="EnsemblBacteria" id="EFI34939">
        <property type="protein sequence ID" value="EFI34939"/>
        <property type="gene ID" value="Dthio_PD2331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="262" mass="29762" checksum="2F42B1A351D95EE3" modified="2010-08-10" version="1">MSREMRLNKALARAGICSRRRADGLVFSGRVKVNDEVVREPGIRVDPEKDSIIVDGRPVKIETEQERELVHVMLNKPVQVVTTTSDPGGRAKVTDLLPDRLRRMRLFPVGRLDYFSRGLLILTNDGDLAHSLTHPSRKIPKVYRVKMRGDLSKKKLQIMRRGMVLSEGEKLAPVEVKILQQTRDSVLAEMTLVQGINRQIRRMCRDLDMVVLSLVRIRQGPLALGELKPGEWRYLEPGEVSQLRKWSSRTNHPQPLLNQGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQC6</accession>
    <name>D6SQC6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate carboxylase</fullName>
            <ecNumber evidence="8">6.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870266.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2344"/>
    <dbReference type="EnsemblBacteria" id="EFI34952">
        <property type="protein sequence ID" value="EFI34952"/>
        <property type="gene ID" value="Dthio_PD2344"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0092">Biotin</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="2"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="123"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="468" mass="53359" checksum="4EF2E89E2FB962AE" modified="2010-08-10" version="1">MKKHKVLIANRGEIAIRILKACMDLGHDFVCVYTREDAQSEHCTEALKQGGEDCLYRISSYQDPNEIFAVADQSQATAVHPGYGFFAEDFRFARRVVQRSRKLEFIGPSWKIIQDLGDKINTKRLARQLGVPTIPGSDRPIFDDLEAEEIARSLFNFQQEQGIEQPVILVKASAGGGGMGIEEVNDPDRFRNVLRKVKNYARRQFRDEGVLIEQRLFDFNHLEVQILADSHGNVVHFGTRNCTVQSTGRQKRIEVAPGFDPGAISYAFDAGRVLDDIINYSVRMAQNVGYNSIGTWEWIVSPTGEPFLMEVNTRIQVENGVSAITSRIEDMEVDLIREQIRIGLGEKMDFDQSSIRFEGVGIEYRILAEDPDNAFTPWVGRIEQFSWPEHPWLRMHTHIPRDRAYDIPTEFDPNLALGIVWGKDLKEAKKRGISFLNQLTLEGRNNVGEPLKSNINYLKEKTDRLLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQG3</accession>
    <name>D6SQG3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870303.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2381"/>
    <dbReference type="EnsemblBacteria" id="EFI34989">
        <property type="protein sequence ID" value="EFI34989"/>
        <property type="gene ID" value="Dthio_PD2381"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002829">
        <property type="entry name" value="DUF116"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43801">
        <property type="entry name" value="PTHR43801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01976">
        <property type="entry name" value="DUF116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="301" mass="33757" checksum="6AF948C305F651F0" modified="2010-08-10" version="1">MSTESQNFLEKEIQDSFEARKRLFIGLITGTSVLVCLILLLLWYIPYVGLDSIHPWAPWVMGTVVALAIGFIFWVSLGLVLNILLKRPVLYSRNLRGISIKFFLPLMTIFGRLLRIPKQKIRASFIKVNNELVLSESRKYPPDKVLMLMPHCLQNSICSRRLTYNVNNCKRCGECSISGLLDLSSEYGVHMAIATGGTIARRIVVNIRPRLIVAVACERDLSSGIQDAYPIPVYGVLNERPKGPCLDTRVTLEHVRLALDKFVDVPMQDSKSSRRGADGSEQVTESRVQLSEISLKNAPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQI7</accession>
    <name>D6SQI7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH/Ubiquinone/plastoquinone (Complex I)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870327.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2406"/>
    <dbReference type="EnsemblBacteria" id="EFI35013">
        <property type="protein sequence ID" value="EFI35013"/>
        <property type="gene ID" value="Dthio_PD2406"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="143"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="502" mass="55619" checksum="0A18E422AD01E29F" modified="2010-08-10" version="1">MIPSILVQIIFIPALVALLIFLFRYQLGKNAGWLAVIGLAYTTGLLLVALTSVSQGDPIKVDYQILINPDIRFSLLADGLSIAVALICNILCLVLCIYSIKYVDHRIELIYEGATYKEEVSYYSCFFYLFLFFPLGFMGVSFAADLVVLYFFLEVLTIILYFLMAYFGYYERVRVATMCLIWGIFSAVLFLAGVLIIYSQIGTFQIDQLHQMSGNPLAFWAILIILIGMFAKLAIIPLHVWMPWVHAEHPTCIAGLLAVYANIAAYVIVRTLVLPLYDDMQVFGPPIMILAVATMIYGSLLTLAQTDMKRIPACSTISQSAYSMLGIGALTAAGIEGGLFFFLSHIMGKTVFFSTCGLVVYMTHIRNINHLSGLAYKMPITAVLFMCGGMMLAGIPPFSSLPAEVIMFTGIFERADAVGITTGILGLMAILLTVGYAFYFTMRIFFGKLPENLKNDDHIKDPPWLMTIPLIGVVLLAAFLGLYPSFILDLFDPVITQVLANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQP2</accession>
    <name>D6SQP2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvoyl-dependent arginine decarboxylase AaxB</fullName>
            <ecNumber evidence="4">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyruvoyl-dependent arginine decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870382.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2462"/>
    <dbReference type="EnsemblBacteria" id="EFI35068">
        <property type="protein sequence ID" value="EFI35068"/>
        <property type="gene ID" value="Dthio_PD2462"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1428605at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01404">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005216">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00286">
        <property type="entry name" value="TIGR00286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="184" mass="20204" checksum="EAA1D205E20D141B" modified="2010-08-10" version="1">MLQRPFVPSRAFFTRGIGRHKNKLQSFELALRDAGIEKQNLVYVSSIYPPYCKMISVQEGISELLPGELTFCVMARNATNEKGRLVGSAVGMAFPADESQYGYISEHHAFGADETEIGDFAEDLASTMLATTLGIDFDPEKDYDERRQIYMMSGQIVDSASAPCVTTGVAGLWTTTISVAVFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQP7</accession>
    <name>D6SQP7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polar amino acid ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870387.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2467"/>
    <dbReference type="EnsemblBacteria" id="EFI35073">
        <property type="protein sequence ID" value="EFI35073"/>
        <property type="gene ID" value="Dthio_PD2467"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="231" mass="25340" checksum="48EADA6CC41E67E9" modified="2010-08-10" version="1">MSFFDLHGYGWLLLQGAKLTLYVGLCSMVLAMGLGLIGVLCKFSRSSLVRFAADTYTTVIRGIPELILILLVYYGVPTLIQDVSAKFGQPVYISFDPFVAGVATIGFIYGAFSTEVFRGAYLAVPRGQVEAARACGMSPALTFRRVVLPQMMRFALPGLGNVWMVLIKATALISVIQLPELMRNADIAARATREPFTFFFAASLIYLFITIGSNLVQQWAEKRASRGIITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR40</accession>
    <name>D6SR40_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870519.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33156">
        <property type="protein sequence ID" value="EFI33156"/>
        <property type="gene ID" value="Dthio_PD0479"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11486" checksum="2279B84D89E7C3F7" modified="2010-08-10" version="1">MENKMPPVHPGEILREELEELTMSASALAKKLDVPVNRVTQILNERRSITPDTALRLSRYFGTSAEFWMNLQQAYDLKTTRELKGSEIEMVVQPHEAASNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR56</accession>
    <name>D6SR56_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0495"/>
    <dbReference type="EnsemblBacteria" id="EFI33172">
        <property type="protein sequence ID" value="EFI33172"/>
        <property type="gene ID" value="Dthio_PD0495"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="6"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="328" mass="39556" checksum="EDB4A699EB7AA5EB" modified="2010-08-10" version="1">MHMTFVLKVFFSREEFVRDFIQYYLPEEIKKHLDLTIIEIDMEGYLSEEFKEFYSDVVAKVYFNDRVHELELYFLFEHKSKPYRFTILQTLNYQVQKWMRLLVEGKLNQHLPIIVPVVIYNGYKSWNFSVQFEDLFQLPSEYYKDFIPQFRHILHDIGQMDEASFKTTTIMEIFHLLLKYIYYPELDTKIHEIYDLLEKLPDNDKLTDYLFIIVRYVMASGAIPEKRLLEHAKRFSGGEEMIGLAAREIEERVEQTRKPYWQKQAKVENSQEMLIKSLKMRFDLVRPSIKEQIRSIQDVDTLNDLFEMSFKCSSIEEFTDLLEKVAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRB8</accession>
    <name>D6SRB8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870592.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0560"/>
    <dbReference type="EnsemblBacteria" id="EFI33234">
        <property type="protein sequence ID" value="EFI33234"/>
        <property type="gene ID" value="Dthio_PD0560"/>
    </dbReference>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020942">
        <property type="entry name" value="Cyt_c_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02085">
        <property type="entry name" value="Cytochrom_CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrom_CIII" evidence="4">
        <location>
            <begin position="54"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="156" mass="17891" checksum="EC7776891380B1B7" modified="2010-08-10" version="1">MRKSMVIGMICAFFVGFVLLPSLYAGLTERHERLDQDMEYEFGSYADEWLLYAPEEYGEMREAPSPFSHTVHGDFDCGECHHDEEGEPWDGTYEIKGCMSEGCHDMAVAEEPQDRRDIRYFYKAYHDLCMTGCHRDLARAGEESGPTACPECHPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRD1</accession>
    <name>D6SRD1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Recombination-associated protein RdgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RdgC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870605.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0573"/>
    <dbReference type="EnsemblBacteria" id="EFI33247">
        <property type="protein sequence ID" value="EFI33247"/>
        <property type="gene ID" value="Dthio_PD0573"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1404568at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007476">
        <property type="entry name" value="RdgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04381">
        <property type="entry name" value="RdgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="204" mass="23517" checksum="16EF3A24C8050C1E" modified="2010-08-10" version="1">MGILSSSVSLTRYRIVENVPDELVSEVPQRLKSNAFREIDQTSDERSFGWVCFDDLLDNQWHTASPHKGHYLAFALRLDTRRIPPAVMKKYLRLALEEARREQESRGRKIVTRDHKAEIKDRVKQTLMGKTLPVPAVFDVVWDVSSHLVYLGSVSPKVRQLFEDQFTQSFDLSLEPQTPYFLAASLVKEHEKKMLDEVEASIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRH2</accession>
    <name>D6SRH2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar hook protein FlgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870646.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0614"/>
    <dbReference type="EnsemblBacteria" id="EFI33288">
        <property type="protein sequence ID" value="EFI33288"/>
        <property type="gene ID" value="Dthio_PD0614"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="704242at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011491">
        <property type="entry name" value="Falgellar_hook_FlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037058">
        <property type="entry name" value="Falgellar_hook_FlgE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07559">
        <property type="entry name" value="FlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="FlaE" evidence="9">
        <location>
            <begin position="422"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="675"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="755" mass="82665" checksum="22EF7EB6796F31A2" modified="2010-08-10" version="1">MGLSSSMYTGVSGLKGHGEKMGTIGNNISNVSTVGFKGSRMHFEDFMSQDINTGAGVGQVGRGVGVGAVMNDFSQGSLESTNEATDVAIGGDGFFQVSARGTDENLYTRAGNFRFDEEGYLVDPNNNVVQGWEVREDPPGVADDDEIIQTETGVEIQGAPGDIRLDDFQSPPEQTRKVDKMVNLDSRSEARSSNASTPLTGDDELGTEANLQINNDYLTAVLSEDDPADPWLLEDEDGTVIRIGLDDGDISFDPDDPNNPPDGDPYELRWNEDLEDFALYDGGWREPIGIDPPDINGGDDLDIDFDEAAVNLQRGGNFDAELVIDGADNIDINFDFDSADHLVRQLNGEDYINADYDSENNTLNISVENEDDDGNNIDELSFEFQNLSSKTASELGVTSYKEGQPFSAMWHNWDATNDDDPISDNRYAYQSTMKVYDENGTSYELTNYFDPVEIDDPSGNKHWEFMTTVNPEHDNREGMEDSEKRGVLMTGALTFNPGGELIDQSAYTLGTEVYDDDTGEPIAGGDFASDLSNWSLSDFSDNGYPVFTPNFLGIEGQNFTGAEGAQNIEMNFGLRNQTGNWEAGSAESPAELTEFGNTDFNFDNIAEFEETRREAQASTQYSSSSTTLMQNQDGYTTGFLQNIEIDRNGVLTGRYDNGQVMDLYALTLADFHNEQGLRKEGGNLFSETRSSGPAMTGLAGTRGLGEISSNSLEMSNVDLATEFVKLIQTEKGFQANSKTIQTTDTMLGIIMQMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRJ6</accession>
    <name>D6SRJ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">Dthio_PD0639</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870670.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0639"/>
    <dbReference type="EnsemblBacteria" id="EFI33312">
        <property type="protein sequence ID" value="EFI33312"/>
        <property type="gene ID" value="Dthio_PD0639"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="118"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="237"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI33312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="389" mass="42680" checksum="9C8A13A93D45DA8D" modified="2010-08-10" version="1">MIGSQGKYFFTSESVSEGHPDKVSDYISDAVLDALLENDSESRVACETLVTTGMVFIAGEITSQGYADLPSIVRETVKDIGYNSSDMGFDWETCAVISSIDKQSPDIAQGVERKSPEEQGAGDQGMMFGYACTETDALMPAPIHYAHKLSRRLAFVRKKKVLDFLRPDGKTQVGLEYENGRPKRIDNVVVSAQHDPNIAYQDLSDAIKKEVIFHTLPPELMDEKTKIYINTTGRFVVGGPMGDCGLCGRKIINDTYGGMAAHGGGAFSGKDPSKVDRSGAYMARYVAKNVVAAGLAERCQVQIAYCIGLAEPVSVLATSMGTGQVDDETLTKAVREVFDLRPYFIIKRLDLKRPIYQMTTNYGHFGREKPEFTWEKIDAAADLKTACKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRL3</accession>
    <name>D6SRL3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0657"/>
    <dbReference type="EnsemblBacteria" id="EFI33329">
        <property type="protein sequence ID" value="EFI33329"/>
        <property type="gene ID" value="Dthio_PD0657"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YT2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="172" mass="19763" checksum="03F924A67332F348" modified="2010-08-10" version="1">MPTVLRRGPYRFFFVALDQAEPPHIHVQREKMVAKLWLDPVVLQNIGGFGRNELNAIAKLVNEINNFSWRNGMSSLAVEKQGARAQNIFVSDASLQIDLTDGRTTIVPLMWYPRLWYGTPEERNNYQIIGDGEYIHWPELDEDLTVSGIIAGHRSAESPSSLKRWLNERMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRQ7</accession>
    <name>D6SRQ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870731.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33373">
        <property type="protein sequence ID" value="EFI33373"/>
        <property type="gene ID" value="Dthio_PD0702"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031BWM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2136683at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022148">
        <property type="entry name" value="CopG_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12441">
        <property type="entry name" value="CopG_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="10482" checksum="F97B8B94D51D663B" modified="2010-08-10" version="1">MQKENKMKNYHRDELPVSFDSIADAADFWESHDSADYEAYMEDVQFNVDINRHVYLIPVAESVLEKVRNKAKHQGVSTETLVNMLLQEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRQ8</accession>
    <name>D6SRQ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870732.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33374">
        <property type="protein sequence ID" value="EFI33374"/>
        <property type="gene ID" value="Dthio_PD0703"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2056748at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="11232" checksum="469FDCB94A8CEAF4" modified="2010-08-10" version="1">MLINSIIWLSDIIDKLEKKHAVTTNDVENIFKDLPVFHRIERGKVKGEHVYRALGRTDSGRYLVVFFIYKRTHEALVISARDMTEKEKKIYAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS06</accession>
    <name>D6SS06_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane lipoprotein carrier protein LolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870824.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0806"/>
    <dbReference type="EnsemblBacteria" id="EFI33472">
        <property type="protein sequence ID" value="EFI33472"/>
        <property type="gene ID" value="Dthio_PD0806"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933827at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="206" mass="23463" checksum="D6F3D6CC91A0544E" modified="2010-08-10" version="1">MIKSALALFVFILMPFTGWGKDQSIPADVLEKLHEIHDSIQTVSGSFVQKKHLDVFDQTLVSRGSFAIDRPGRIRWAYEEPSVFGFSSDGLQVRRWSEESGMSQSAPLSRDPVLSVIVDQMLAWSTMDLQAIEDHFSLTLAESEPMVLELEPEAKELRDIISKVLISFDSTSTHIEKIRILEHDSDRTNIRFEEVSLNQDLDHELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS31</accession>
    <name>D6SS31_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxyl-terminal protease</fullName>
            <ecNumber evidence="5">3.4.21.102</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.102" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870849.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0831"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="EFI33497">
        <property type="protein sequence ID" value="EFI33497"/>
        <property type="gene ID" value="Dthio_PD0831"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="80"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="426" mass="47387" checksum="7BB367A68F30C742" modified="2010-08-10" version="1">MRINHLIGTIAILLLLTVAPWTSQARDNDMDSLKMFSEVLHLIEDNYVEEKDREDLIRGAIQGMLRNLDPHSSYVDLDQLRMMQEDFEGKFGGIGIQIGIRDGNLVVISPIEGTPAYEAGLEPGDVIMEIEGEPTQDMALTDAVNKIRGPKGEPVELTILSEGSQSPEKVKIVRDDIPVHSVKSQELESGYLHLRITDFKATTTEDLKEEIRKYSSEKEIKGIVLDLRNNPGGLLDQAVSVSDIFLDDGLIVYTQGREEAQRKDYSATSSAEDVTSPMVVLINAGSASGSEIVAGALQDRNRALLLGEPTFGKGSVQSILPVADGSAIKLTIANYYTPDGRSIEAEGVAPDIHIPHRVDAVDEDEQQQEMQESMMQFHIDQPDERPDDEEERYSEEVQKLLDEDNQLRMALELLRSMPRIQELSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS44</accession>
    <name>D6SS44_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0844"/>
    <dbReference type="EnsemblBacteria" id="EFI33510">
        <property type="protein sequence ID" value="EFI33510"/>
        <property type="gene ID" value="Dthio_PD0844"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033GEX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12810" checksum="21A0785C2858EB91" modified="2010-08-10" version="1">MLQQSAPATRPGLEEVKRQFEHWRETRHTRSPIPNHLWASAVSLAQDYSICKIAKVLHLNHSHLKKRVQAEQAQESLQPGPSFVEFELTSSLPCTDITWRPKLEMDQAQNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS52</accession>
    <name>D6SS52_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870868.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0852"/>
    <dbReference type="EnsemblBacteria" id="EFI33518">
        <property type="protein sequence ID" value="EFI33518"/>
        <property type="gene ID" value="Dthio_PD0852"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503339X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2054386at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="8383" checksum="4B985A2B6410DB0F" modified="2010-08-10" version="1">MEHQLVICIKNKGYEASLEARKLYEAIPDPKAEKHQQIRVIDESGKDYLFPKELFVIVELPKPVEEAIFREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS67</accession>
    <name>D6SS67_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purD</name>
        <name evidence="10" type="ORF">Dthio_PD0867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870883.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0867"/>
    <dbReference type="EnsemblBacteria" id="EFI33533">
        <property type="protein sequence ID" value="EFI33533"/>
        <property type="gene ID" value="Dthio_PD0867"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="421" mass="45479" checksum="092AC13A7F5229CA" modified="2010-08-10" version="1">MRVLIVGSGGREHALAWKIRQSPRVERLFIAPGNGGTALEGENVAVDVDDIPGLVKLARTKKVDLVIVGPELPLVLGLTDALEKENILCFGPGAYPAQLEGSKAFAKSLMSQAEVPTAGYRVFEDFNQAVKYVQGRDFPVVIKADGLAAGKGVVVADDFEQAREALDDMLVKQVFGKAGERVVIEEALSGEEASFLALCDGRNFLLLPSSQDHKRIGENDTGPNTGGMGAYSPAPVLPAAKYQETADLVIRPMLQHLEQTDQPFKGVLYAGLIFSEDGPRVLEYNVRFGDPECQPLLMRLDSDLLEVIMACVHGRAAERSLQIKDEASVCVVLSAGGYPARYTKGHEITGIEEAETDPLVRVFHAGTAYKDGRLVTSGGRVLGVTALGTDLGDAIERCYRAVEKISFEGMYYRRDIGQKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSB4</accession>
    <name>D6SSB4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyl-viologen-reducing hydrogenase delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0915"/>
    <dbReference type="eggNOG" id="COG1908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003813">
        <property type="entry name" value="MvhD/FlpD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02662">
        <property type="entry name" value="FlpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0711">Selenium</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="FlpD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="3">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="15908" checksum="FE5FD69C173AA1DA" modified="2010-08-10" version="1">MAEHKEPVIVGFLCNWCAYAGADLAGVSRLQYPPNMRAIRVMCSGMVHPNLVVEALEKGADGVLVLGUHLGECHYLDGNHKAYARAQAIKLVLEDLDIDPERFRLDWVSSAEAPRFAKVVNEFTDKIKSLGPNPLRVSKETQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSJ2</accession>
    <name>D6SSJ2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">murJ</name>
        <name evidence="10" type="ORF">Dthio_PD0994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0994"/>
    <dbReference type="EnsemblBacteria" id="EFI33658">
        <property type="protein sequence ID" value="EFI33658"/>
        <property type="gene ID" value="Dthio_PD0994"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="515" mass="54994" checksum="FA07DB5F6692BA37" modified="2010-08-10" version="1">MSTRESKSPPFSSLARKASVVAGATLVSRIMGFIRDLIIAFTLGAGPMADAFFVAFRIPNLLRRLFAEGSLTMAFVPVFTKIKKESGAQSAFALARSVQIWLLLILGGITLLALFFAAPLTMLVAPGFREDPEIFETTVTLVRICFPYIIFISSVALCMGILNSMNHFMAPALAPALMNITLILSALGAYYSGMSVALALSFGVLASGLIQWLFQYPFLKKSGFGWRGNFSLFDPGVKRIGKLMLPTVFGAAVYQLNILAGTILASFLASGSIAYLYYADRLVQFPLGVFAVAIGTAALPSLSSLAGDRDMQGFKGTLNSSLSLTLFIALPSTAGLIGLSYPLIDVIFGRGAFGDDAVQATSLALVGFAVGLPAFSCVRPLLSAFYALEDTVTPVKIAVISLVLNIALGILLMQHLQHLGLALAASLSSWVNVLLLGLALGRKTGPWLTAGTNLVKMTLASCALLFMLKFVSVTSWMAMALIPVWAVIYFALAWMLKIPDAQILINSLKHKSGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSK0</accession>
    <name>D6SSK0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871015.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1002"/>
    <dbReference type="EnsemblBacteria" id="EFI33666">
        <property type="protein sequence ID" value="EFI33666"/>
        <property type="gene ID" value="Dthio_PD1002"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TGZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724961at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="14697" checksum="217D8EDE01CDED80" modified="2010-08-10" version="1">MSEENRQEQDRHKKAIYDSLAPRRKKFIDRIGYDRWDPFQEPKNPIEIRRDGTQRTSKELMRMFLHERPPREYSNSYGQGVLEMCMGIINDEDRIRAMYEFSLWYSELLKRENKEYKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSN2</accession>
    <name>D6SSN2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871047.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1037"/>
    <dbReference type="EnsemblBacteria" id="EFI33698">
        <property type="protein sequence ID" value="EFI33698"/>
        <property type="gene ID" value="Dthio_PD1037"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2085781at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="14030" checksum="0FB9352BFE2DF997" modified="2010-08-10" version="1">MTTSQVLFISTEDHDEQVQNMLVDYGVQVTKISSMQELKEPETKGEYSIVFLDLDLPCVSNNSIYWLRKMTGQAWIIGLSSKRYHPELKESMRSDIFAVLGKPAHSRELQYCLHSLFDLQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSS9</accession>
    <name>D6SSS9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871094.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1084"/>
    <dbReference type="EnsemblBacteria" id="EFI33745">
        <property type="protein sequence ID" value="EFI33745"/>
        <property type="gene ID" value="Dthio_PD1084"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="220274at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="52"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="375"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="620" mass="69177" checksum="462483090E734E41" modified="2010-08-10" version="1">MQSIMTEQEFQPENSMTQAFNDYPVWQWLDRLSRISSELSRVIAGRENEFLEIGQGVQDLYYRSRDLSATALELGEKASGSALKEAMEELDSSLKEIQGQSEDTNLEKTMNRCSDLGVAVGKLHKEMQHFRPMLKHLRVLAMSIRIESARMGEQGRHFVTLAQEVENLGYKTEEYSRDATERIRGLQNEVQSLQVSVNSAHNLHSREITPLLEGVHEKSRQLQEMQKSSERLSGSIAGRAESIKEMVGEIISSVQFHDITRQQVEHVYQSLDEARDVFQGEQREEDQVQDMIRWLGDVCSLQSRQMESTRSGLGKAMDSIRQSLGGIGDYVQEQEADMQGFTGLDSGSGQGVLAGLEQDASSLIPVLEKSTSDFEDVIRRLESMSSDLEGMQSLMDTLEDIGEEIALIALNASVKSAHTGEGGKPLGVLAGAIHRLSGDTKNVVASVSGVLEEILSVAGDFSSHAEKARAGSQNEARLCSILGQVVNRMSGVNTEVTALNRNLREETSKLLKLSTKIQKKLDMQFEVQEEISGIIKDLQEVEQQIQEHVPPVESGERYSQRLSNILHRYTMESERSVYRDFTGQGQEEQGHGQEAAEAHEPELFTDTEGEDEFGDNVELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSW5</accession>
    <name>D6SSW5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate/ketoisovalerate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871130.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1120"/>
    <dbReference type="EnsemblBacteria" id="EFI33781">
        <property type="protein sequence ID" value="EFI33781"/>
        <property type="gene ID" value="Dthio_PD1120"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="21231" checksum="639C4E7280C89D12" modified="2010-08-10" version="1">MSNDLHLDRFEVRLSGLGGQGILTLGRIMGQALALDHGYEVTQTQSYGPEARGGASRCDLVISTGKISYPKTICLDLLVSLSQEACNKYFGDLKTEGFLLVDTSLVGQTPTNIFWGLPFTTMAQKVGLVQTTNIVALGALTHFIPFMRATSVRKSLKEILPQKIVDINIKAFNSGFNRAKKEYPEAPEKWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSY5</accession>
    <name>D6SSY5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871150.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1140"/>
    <dbReference type="EnsemblBacteria" id="EFI33801">
        <property type="protein sequence ID" value="EFI33801"/>
        <property type="gene ID" value="Dthio_PD1140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="35"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="29707" checksum="6151E7AA1AB061B7" modified="2010-08-10" version="1">MTLKSNSTWRLGTTSYIIPDHILPNLYYLQDKVDDVELILFESGEQSSIPDASQVRLMQSLAKDSGLSYTVHLPLDLYPGARDEALRRTCTETWKRIVGLMQPVDPVGWVVHLNDPPRDEDFLPAWQEQCRKSLEELSREVEPGLLCIENLDYDHELIWPWVLEMGFSLCMDLGHLQVRGEDLPACLDRWLDHVRIIHLHALNSEGRDHTGLQHMDRDLLAWLLSSFDSKTRPLVVTLEIFSSKHFQGSLKAIQEARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSZ3</accession>
    <name>D6SSZ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871158.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1148"/>
    <dbReference type="EnsemblBacteria" id="EFI33809">
        <property type="protein sequence ID" value="EFI33809"/>
        <property type="gene ID" value="Dthio_PD1148"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1975434at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="172" mass="19185" checksum="527CD905174065DB" modified="2010-08-10" version="1">MSTTYPKAQRLSIGYDPREDRLILTGHLQTGEDREAMITRRLLSRLLDKMSSELSSTHPAAERSPDPDEVLQMEHIAAVTQGRSEQSSSEASQEKAAVKKYLAVEAQVETQDEHLILGLIAEDKTPITGIKLSRAKAHQVLRMLMEQAGKAEWELEQKAAWMQPMKYGKGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST05</accession>
    <name>D6ST05_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871170.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1160"/>
    <dbReference type="EnsemblBacteria" id="EFI33821">
        <property type="protein sequence ID" value="EFI33821"/>
        <property type="gene ID" value="Dthio_PD1160"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1934843at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="154" mass="17415" checksum="6B90D4B0AB4BF0BF" modified="2010-08-10" version="1">MKRIFEHNRFTAGSRHWAGGKNAGRAMLTLFMLAFFCLGMGGTSGTFGPAAEKDRFFRAEIKDRSDKSHEVQGIFVQGSTYLPARTGSAEAEVDFGKIESARFYVQDDRVLARVTMVNQEEMDFYIQPQTTFQGKTDWGSISFRADEIKEISFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STC0</accession>
    <name>D6STC0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871285.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1275"/>
    <dbReference type="EnsemblBacteria" id="EFI33936">
        <property type="protein sequence ID" value="EFI33936"/>
        <property type="gene ID" value="Dthio_PD1275"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Z92">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015352at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="8035" checksum="4D7A504081C92835" modified="2010-08-10" version="1">MTELLRKAFEEASRLPEMEQNALARRLINEMVSEKQWDKAFAESEDVLDKLADEAIKEREKGETKPLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STH1</accession>
    <name>D6STH1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putitive phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871336.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1326"/>
    <dbReference type="EnsemblBacteria" id="EFI33987">
        <property type="protein sequence ID" value="EFI33987"/>
        <property type="gene ID" value="Dthio_PD1326"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1837604at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="PTHR36536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="26111" checksum="423CC3AE9B7569C2" modified="2010-08-10" version="1">MRMNFFGLLSNKSPMEGLHDHYEKIHESIEVINEALECYIGGGDKCPEFISLQSRINELESQADKIIRHIRNHLPRGLFMTVDKIQFLNYTSVQDNILDAAQEALNWLGMREVNIPEEFQRDLLFLQGDVVKTLAMVGPALRETTALVHMESMNREELKESLRKIREQKDKVFRNKNEITRKVFNSDLEFKDIYQLIHYVDKLYLMAFNSSKCAEILRTMIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6STL6</accession>
    <name>D6STL6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transketolase</fullName>
            <ecNumber evidence="3 8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1371</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871381.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1371"/>
    <dbReference type="EnsemblBacteria" id="EFI34032">
        <property type="protein sequence ID" value="EFI34032"/>
        <property type="gene ID" value="Dthio_PD1371"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="188169at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="666" mass="73007" checksum="9DC3170E01CD18A3" modified="2010-08-10" version="1">MSTSKDLATAIRVLSMDAVQKAKSGHPGAPMGMADMAVPLWREILAHNPANPKWPDRDRFVLSNGHASMLLYSLLHLTGYDLSINDLRNFRQLHSKTPGHPEYGVTPGVETTTGPLGQGLANAVGMALAESILAARFNRENLDIVNHYTYTFLGDGCLMEGISHEACSLAGTLGLGKLIALYDDNEISIDGQVSGWFTEDIPSRFTAYGWHVISGVDGHDQDEVKNAILEARNETRRPSLICCKTVIGHGAPNLCGSADCHGAPLGDGEIQAARANLGWEHPAFEIPEYIYQAFDCRERGARLEEEWNSKFAEYQAAYPEQAREFLRCIAGDLPGNLDQTVSEMIKNFDQDKQPLATRKASHKIIDVLTAELPEMLGGSADLTGSNKTMRTGARPVSKKNKDGDYIYYGVREFAMGAIMNGLALHGGFIPFGGTFLVFSDYSRNSLRMGAMMGLRCIHVLTHDSIGVGEDGPTHQPIEHTASLRLIPNMSVWRPCDTVETAVAWHSALKRNDGPTCLVLSRHKLKPMQRSTTQLENIRRGGYILLDCEGTPEAIILASGSEVEPALDAAKELGAKGRRIRMVSMPSINFFMSQDINYQKEVLPREVEIRLAVEAGAGASWHQVLGCRGEAYGIERFGESAPGSILFPYFKMTSTDIAQKLLDMLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6STN2</accession>
    <name>D6STN2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bioD</name>
        <name evidence="6" type="ORF">Dthio_PD1387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871397.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1387"/>
    <dbReference type="EnsemblBacteria" id="EFI34048">
        <property type="protein sequence ID" value="EFI34048"/>
        <property type="gene ID" value="Dthio_PD1387"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="205" mass="22286" checksum="14BD2F08484F185C" modified="2010-08-10" version="1">MLFPRCFFVTGTDTGVGKTVISALLAAGLEAYYWKPVQSGSDQGLDSQQVALWAGLDRVKIIPEAYTLRQPLSPHLAAERDGVFIDPQRLHIPDAQGTLVIEGAGGIMVPLNNDLLILDWVRSLAVPVLIVAPNRLGVINHTLLTINALGCYGVKILGVILNGEPNMDHVQAIEYFGRTPVLAQVQTMPEITPQLLKSKFAEYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6STN5</accession>
    <name>D6STN5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871400.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1390"/>
    <dbReference type="EnsemblBacteria" id="EFI34051">
        <property type="protein sequence ID" value="EFI34051"/>
        <property type="gene ID" value="Dthio_PD1390"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1625084at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="208" mass="23540" checksum="D591DDADB8104177" modified="2010-08-10" version="1">MAKRVLFISGWAGYPELFPHLGTHSFFVLPFVSHSQSDIKKLLRSHAWDIVLAWSLGASLCLQCLGSISTRHLVLIAPFLDFTRHTPVNGIQDMLNGLGKNPETTVRWFWRRCGIKSAPRVRRGDVEGLARGLEYLMQPGPEHVQHREMKFPATLIHANQDKIVPRQALLEVHAALGQGRPVYTPGGHFIAEERIWQIIHEQTGTKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6STP2</accession>
    <name>D6STP2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871407.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1397"/>
    <dbReference type="EnsemblBacteria" id="EFI34058">
        <property type="protein sequence ID" value="EFI34058"/>
        <property type="gene ID" value="Dthio_PD1397"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="171" mass="19259" checksum="147EB83145F3CAD1" modified="2010-08-10" version="1">MSSYLIKINGKRCISCKACEVHCKAKNRVPEGARLGQLVTIGPVKRKEKPRYLNLFLPCFHCETPWCVHACPTGALYKRDKDGIVMVQEELCVGCKACIMSCPWDIPQWDETNGRIMKCDYCSDRIDRGEKPACVTACTAHALSFIDPNQASARTRESFASRVLLSRQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STY7</accession>
    <name>D6STY7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1495"/>
    <dbReference type="EnsemblBacteria" id="EFI34153">
        <property type="protein sequence ID" value="EFI34153"/>
        <property type="gene ID" value="Dthio_PD1495"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033NXH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047837at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="131" mass="15226" checksum="0BC0AA65296B2E69" modified="2010-08-10" version="1">MFMVYTESFSNVRDFFLLIRRKKDLARRAASEAKLKEEKLQGLSSVFRKHGVSCAYVFGSVHTGSCRRDSDIDLYVEAVTPDDFWKLWRDLETRTGENIDLYCDRDDPVFTRKIKQRGKLIYESGNSPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6STZ9</accession>
    <name>D6STZ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871512.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34165">
        <property type="protein sequence ID" value="EFI34165"/>
        <property type="gene ID" value="Dthio_PD1509"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10779" checksum="2167F4495BD55A4A" modified="2010-08-10" version="1">METIADMLEKKGYERGYDTAYQEKPKWEKHAKLEATQETLIDAATEQYGPLPGMLHEKIKSIKSLENLRALNRKVIRTQSLDEFTELVNRAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU44</accession>
    <name>D6SU44_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871520.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0131"/>
    <dbReference type="EnsemblBacteria" id="EFI32824">
        <property type="protein sequence ID" value="EFI32824"/>
        <property type="gene ID" value="Dthio_PD0131"/>
    </dbReference>
    <dbReference type="OrthoDB" id="974017at1224"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11907" checksum="D049F41B13FC23B4" modified="2010-08-10" version="1">MTPSNSNLDHSTDSITLSQYKRLVAPRPWLWWDTDDLTGLSLDSVVEGILARGDWPDFLEALDELGLDQVREIFLRQVNRQRNNYRAQTRNLFQIYFERHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU87</accession>
    <name>D6SU87_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0176"/>
    <dbReference type="EnsemblBacteria" id="EFI32867">
        <property type="protein sequence ID" value="EFI32867"/>
        <property type="gene ID" value="Dthio_PD0176"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032M3D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="12351" checksum="560F48C85A7EBF89" modified="2010-08-10" version="1">MNTLVKMQEALEKRNIIWRRHVLSRMLERNISRDDVFNAIQDGEIIESYPEDKPYPSYLISGFSGNKRIHVVASWDDGAQAVYIITAYIPDEDHFQENGIARKARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU96</accession>
    <name>D6SU96_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871570.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0189"/>
    <dbReference type="EnsemblBacteria" id="EFI32876">
        <property type="protein sequence ID" value="EFI32876"/>
        <property type="gene ID" value="Dthio_PD0189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1772839at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021799">
        <property type="entry name" value="DUF3368"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11848">
        <property type="entry name" value="DUF3368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="162" mass="17816" checksum="0CEC1436E5AC0274" modified="2010-08-10" version="1">MKAISNSSVLIGLSSIGRLSILHNRFPQGIIVPWAVWEEVVETGHGLPGAQEVARAEWITTQQVQNKVFSLSLQVSLDRGEAEVIALNQEINADILLLDEKSARSIAVRLQYTVLGTVGVLIWAKRNSLLSNLSQELDLLQQKGGFRLSKDVYELAIQKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUA7</accession>
    <name>D6SUA7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="9">CMK</shortName>
            <ecNumber evidence="2 9">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ispE</name>
        <name evidence="13" type="ORF">Dthio_PD0201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 9"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0201"/>
    <dbReference type="EnsemblBacteria" id="EFI32887">
        <property type="protein sequence ID" value="EFI32887"/>
        <property type="gene ID" value="Dthio_PD0201"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1938933at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="12">
        <location>
            <begin position="222"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI32887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="297" mass="32461" checksum="ABCEDBF7084EDB34" modified="2010-08-10" version="1">MPPAKIKPMSKTYSIKSGCKINLYLKILDKRRDGYHNLDSIFYPLSRPGDYIDVILVPGSGISLRACPKSLEKSSNILLNTYKLFAAATGFRPGLKVYLSKNIPVGAGLGGGSSNAASFLLFLNSLNRATALTREKLFELASELGADVPFFIYNRPARVTGKGEIVSPVHIGLHGLHLLVICPEVSIDTARAYQAHDQKTRDSRPPGDSVLTTGPLTDNRSPFERIILSNCFEKTVFAEYPGLGSIKTQMLQAGASGCVLSGSGSSLCAFFRERKYLSQACHTLDRQNVSFYYSRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUD2</accession>
    <name>D6SUD2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0226"/>
    <dbReference type="EnsemblBacteria" id="EFI32912">
        <property type="protein sequence ID" value="EFI32912"/>
        <property type="gene ID" value="Dthio_PD0226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI32912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="242" mass="26632" checksum="33032D4AEAB9F2D6" modified="2010-08-10" version="1">MKIVECRKVCKSFGDSQVLHDIDLSINSGEVVVVLGPSGSGKSTLLRCINVLETITSGDLLVDGKSVVDPGTDLRHIRQEAGMVFQQFNLFPQMTALENVAFGPRKVRGTDKKEANDQAMELLTKVGLAERAHYHPSQLSGGQQQRVAIARALAVKPKLMLFDEPTSALDPELKGEVLSVMRSLAEEGMTMIVVSHEIRFALNVGNRLIFMDNGSVVHDGDPKELYENPPTERLRDFLHAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUG6</accession>
    <name>D6SUG6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871639.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0260"/>
    <dbReference type="EnsemblBacteria" id="EFI32946">
        <property type="protein sequence ID" value="EFI32946"/>
        <property type="gene ID" value="Dthio_PD0260"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="246"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="350" mass="37926" checksum="79DE71D300A63B61" modified="2010-08-10" version="1">MSRIFVKGNEAIARGAVDAGCRCYFGYPITPQNDIPEYLSRVLPASGGEFIQAESEIAAANMLLGAGACGVRAMTSSSSPGISLKQEAISYMAGSDLPGVIVNISRGGPGLGDIGPSQGDYFQAVKGGGHGDYRQIVLAPGSVQEAYDLTFEAFDLAFEYRNPVMILGDAILGQMMEPIDTREPAGPDPQEAASWRLEGSGERSPRIIRSLRLAEGTLGRHNQDLQEKYIKARKECRHEEFLTSDARLVVVAFGSIGRIVKSTVRKLRKEGHMVGLLRPITLFPFPAPALQDLARQGKRFMTIEHNMGQMVEDVRLSICGLAESGFYGHLPGNLPTPEDFEEPILKELTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUR0</accession>
    <name>D6SUR0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871733.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0354"/>
    <dbReference type="EnsemblBacteria" id="EFI33040">
        <property type="protein sequence ID" value="EFI33040"/>
        <property type="gene ID" value="Dthio_PD0354"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1381894at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="75"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="261" mass="29918" checksum="85341CE726842D96" modified="2010-08-10" version="1">MKWIRCVFRIAASLALAACYALASCTVAILVRDFNQRLHWYSRNTGFFSPLLLKIMGVRVNIVDHTGGQGIRPGTLLVCNHLSYKDIFILSSLRPMLFISSVELSRTFFLGRMARFGGTVFVERRSPAGLRREIRQISDLLRQDFVLTLFPEAGTSDGEGLFPFKPALFQSAIQAGTRVQPVCIRYCALDGRPVNSARRRRVVWHRTLFITHILKLFTHSRVQADVEIFSPINAADKSRKDIMQQSFRLIQDCYRQELERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUT1</accession>
    <name>D6SUT1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871754.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0375"/>
    <dbReference type="EnsemblBacteria" id="EFI33061">
        <property type="protein sequence ID" value="EFI33061"/>
        <property type="gene ID" value="Dthio_PD0375"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z80Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="857043at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029433">
        <property type="entry name" value="DUF4438"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044909">
        <property type="entry name" value="TM_1086_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044910">
        <property type="entry name" value="TM_1086_SG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14505">
        <property type="entry name" value="DUF4438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="32169" checksum="0B9D6F80B6F0D3FE" modified="2010-08-10" version="1">MNKEKNKLSTNKEHIIEFLLEGKPGPPKAQAGWGLDHEGSPFILPSIGGITLNVQVGDSAFGWAGDHVEPGVSCTGNTHKPAEHPNNSLQLFSCIGNRATVISGEAKGSPGFVMGKHGGSEHLILDFSREIKEKLSYEDTIRIHARGQGLQLTDYPEIALQNLDPDLLELMDIEINDKSGIKVPVTAIVPAVCVGSGTGAAHTAKGDCDIITSDRDSVDKYALDSLRFGDFVALMDQDHRFGRTYRQGWLAIGVISHSDCRRAGHGPGVTTVMTAESSLIEPVISRKANVGVLLDIGTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV03</accession>
    <name>D6SV03_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gp157 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871853.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0048"/>
    <dbReference type="EnsemblBacteria" id="EFI32759">
        <property type="protein sequence ID" value="EFI32759"/>
        <property type="gene ID" value="Dthio_PD0048"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DHI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1870508at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008840">
        <property type="entry name" value="Sipho_Gp157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05565">
        <property type="entry name" value="Sipho_Gp157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="18975" checksum="CE9B91AB3C064A3A" modified="2010-08-10" version="1">MPSFDAIQDEISNFLSVSEELTEDQHVPALNYLEELALQEQSKVDAIGYAVRKRKAEIDFLKQEEERIRHRRKSMENRLEEFKDYLLAVLKKHNLQKVKGLSSTIYTRNVSSVKLNNLDGIPEKFKKIVTEVKVDKRGIAEELKQGWHIPGVELEQRLSLTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV08</accession>
    <name>D6SV08_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871856.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0055"/>
    <dbReference type="EnsemblBacteria" id="EFI32764">
        <property type="protein sequence ID" value="EFI32764"/>
        <property type="gene ID" value="Dthio_PD0055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2181482at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="556" mass="59976" checksum="CE399BEDBD387191" modified="2010-08-10" version="1">MEELPEEYKIDPAEAFDAGAVTVEDAGEAYAKVETILDGAQNADELELEDLFEWSIADTAENILDAKEEATVTGAASVGLADDEYASVEQAEALLELDNFDGVYNLSDSAENILAEEAQEVVAAAEEVSVTDAVTVADATALSELENFDGVYSLEDTIENLLTNKASEVLIINDAQEANVDGVATIAQIQDYQDRGYDNLNTYNLEDTAENYIEEGDSELVQGAESYAVSEPMTVAEYNDMVDEGFEDFEYELADTLDNLVAAEEGVVGDAGEYNLTDEADAFEALPAAEAMDADMFAVFDNATNRADYTYSLEDSLENLVGLDEGVVGNADSYTLTDDAAAFEGLTVEDILSQEEADMLSGAANTDDYTYSLEDEADAFFSNGAVEEDLVDLLDDPDSITVTTATTQEQRDALDAINDNVDYEGGLEGKTFTLTEDDATLTQDFSNGVDPDDVFLTGANDTINAGTNLGDDVYIEDPSTDDNDQLNAVLGNDNPAPTLINIETIQIRSINDNAELDMVNIDGTNLVMINPASSRDLTFSNFDHTYSLTTRNLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJQ1</accession>
    <name>D6SJQ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module component, TIGR02574 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869229.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36104">
        <property type="protein sequence ID" value="EFI36104"/>
        <property type="gene ID" value="Dthio_PD3556"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2087795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013406">
        <property type="entry name" value="CHP02574_addiction_mod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09720">
        <property type="entry name" value="Unstab_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02574">
        <property type="entry name" value="stabl_TIGR02574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8542" checksum="11D09485A70E2C99" modified="2010-08-10" version="1">MVTKEIKEKILALNEVERVRLAEFIFDSLDKPDPEVEQKWIEESERRYQAYKEGRINPVSMNEIRQRYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJS9</accession>
    <name>D6SJS9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869257.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3585"/>
    <dbReference type="EnsemblBacteria" id="EFI36132">
        <property type="protein sequence ID" value="EFI36132"/>
        <property type="gene ID" value="Dthio_PD3585"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2100386at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="7158" checksum="7F9A63C9099A25D2" modified="2010-08-10" version="1">MPENGGDPKTQAVTWDEIAYSNMIQHEALISLLLEKGVITKEEYLDRVRQITEELQDRKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK67</accession>
    <name>D6SK67_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="11" type="ORF">Dthio_PD3733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869389.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3733"/>
    <dbReference type="EnsemblBacteria" id="EFI36270">
        <property type="protein sequence ID" value="EFI36270"/>
        <property type="gene ID" value="Dthio_PD3733"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162005at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="389"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="7">
        <location>
            <begin position="392"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="444"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="498"/>
            <end position="501"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI36270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="889" mass="96882" checksum="0F2B38140F255D22" modified="2010-08-10" version="1">MTTKMRVRDVSQELGISNKELIGLLRELNIPVKSHMSGLTEEQVDLVRDRHKSAAQEGVSQSRAKSGVIVRRRKKPAPEPAPEPEAEEAEEAEAVTQDTVAAPEKPVDAKAPEEHLQETPAREPAAEDGDQAQKQEVTQEPDAADQHKQEAAPEEARDKEARRDRPPRKGARKKKAPPEEPKVKVISRPEPEAEPRTTVTPEPAKPEVTEPAPDKAAPPAAPAADDDSKDGKKKRRKKKDKKDKRVVEFDSLQQEGIDQKQAKTGFKKQKTSPVADRTGGKARPGRGRKPRPEPKVQETVQPTRAAKKKIRIDEAIRVSDLAKQMGIKAQDLIKTLLGLGIMATINQSIDLETASIVAAEHGYEVEKTGFSEDEFIIPREADKPEDLLPRPPVVTIMGHVDHGKTSLLDSIRKSKITSGEAGGITQHIGAYYVGSDRGDIVFLDTPGHEAFTAMRARGAQVTDIVILVVAADDGVMDQTREAVNHSKAAGVPIVVAVNKIDKEGADPDRVKRELSELGLVPEDWGGDTIYTHVSAKQGTGIDEILEMVLLQAEVLELHANPNKYAVGHIVEARLDKGRGAVGTVLVQGGTLKHGDAFVCGLYHGKVRAMFNDKGKKIDQAGPAVPVEIQGLEGVPEAGDEFVVVQDEKVARRIADARQTKQRDKDLAKESKITLESFLASKAEGETHQLNLVVKADVQGSLEAITEALNKQSTSVVKINIIHGGAGSISESDIMLASASSAIVIGFNVRPTPRVKEVAERESVEIRFYDIIYNLVNDIRDAMAGMLDPIIKEEYLGQAQVLQTFSVPRVGMVAGCMVMDGKLIRNGKARLVRDGVVVYTGNLSSLKRFKEDVKDVTKGYECGVGLEKFNDIKVGDIIEAYQEREEKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKE5</accession>
    <name>D6SKE5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein Dthio_PD3816</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869467.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3816"/>
    <dbReference type="EnsemblBacteria" id="EFI36348">
        <property type="protein sequence ID" value="EFI36348"/>
        <property type="gene ID" value="Dthio_PD3816"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1883809at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="100" mass="11007" checksum="25C6C58E19785063" modified="2010-08-10" version="1">MQDLVKQAQMMQKKMAKMQEELNAREVEASAGGGMVTVKVNGGQEVLEVRIEKDVVDPEDVEMLQDLILAATNDALKRAREMVQGEMSQLTGGMKIPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKK5</accession>
    <name>D6SKK5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylacetyl-CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20956"/>
            <dbReference type="ChEBI" id="CHEBI:18401"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57390"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylacetyl-CoA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868350.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2625"/>
    <dbReference type="EnsemblBacteria" id="EFI35216">
        <property type="protein sequence ID" value="EFI35216"/>
        <property type="gene ID" value="Dthio_PD2625"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="UniPathway" id="UPA00930"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006444">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="80"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="335"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="433" mass="48754" checksum="4EB571BC13CDF8D3" modified="2010-08-10" version="1">MVFDVQKETLPRDELETLQLKRLKYLVQKIYHNVPFYKQKFKELGLKPENLKSLFDLRQMPFTEKQDLRNNYPFGMFAVPRESVVRVHASSGTTGKATVVGYTQRDVETWAGLMARSFEAAGATRTDIIHNSYGYGLFTGGLGAHYGAEALGATILPVSGGATKRQVMLMRDFGSTVLCCTPSYSLHLYETALASGISISDLKLRVGIFGAEPWTEEMRQDIQNKLEIKALDIYGLSEIMGPGVGMECIAAQDGLHLWEDHFLPEIIDPDSGEPLPVGEKGELVITTLTKEAQPLLRYRTRDITRLNPVPCRCGRTHYRIERITGRSDDMLIIRGVNVFPSQIESILLETEGLSPHYQLIIDREGGMDTLEVRVEVHESMFSDEIRHLQRLEKKISGHIKEFLGVTAKTTMVEPQGIARSEGKAQRIIDRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKM7</accession>
    <name>D6SKM7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868372.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35238">
        <property type="protein sequence ID" value="EFI35238"/>
        <property type="gene ID" value="Dthio_PD2649"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="187" mass="20635" checksum="01BE83014D38F202" modified="2010-08-10" version="1">MLSREKALDMVREKVQEENLVRHSLATEAVMRSLARRLDQDVETWGLTGLLHDLDYTLTQEDYSRHGLESAQMLQDQLPPEAVRAIEAHAAELNHAPAPSSTLDHALRCAETVTGLVMAAALVRPEKLSGMKAKSLKKKMKDKAFAASVNRAIIAEHEKLGLDQNEFLSLSIQAMEEIAPDLGLGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKP3</accession>
    <name>D6SKP3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868387.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2665"/>
    <dbReference type="EnsemblBacteria" id="EFI35254">
        <property type="protein sequence ID" value="EFI35254"/>
        <property type="gene ID" value="Dthio_PD2665"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="947558at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="45"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="507" mass="57006" checksum="F0FC259675D14B2B" modified="2010-08-10" version="1">MPSDIFQAIGLKGNPFSPATSTKGYFHTQATQRILEEIHFGVSQRRGFLLLIGEVGVGKTSLLLQLLERIHSSPEDKLRSAWVFNSMMDRMELMKTIIRDYGLTPAKNATFSELLSQLHQFFLEVNSNGGNCAIIIDEAHNFDIHTLESLRLLSNLESDEKKLVQILLSGQPELQVRLNCNELRQLRSRIAISNTLPALSRDEVKRYVDFKLSSTSSQLYLPSSSCRLLHRSTRGNVRLINLIMERSLHAMYALDQTTINPGIVHAAIQEVGTFQQDIRQNYSFKKKILCAALILALVLPAAYLVKQQAGSPIIQGQDSAPQQQTGSGNAGTQAGEGMRTVEHDTVLQIVPDASVTREKLHSFLEPFDQENLAEVMLQALWVNSPEVLHDKLPDDLLLAGVHDLPDNNGLKFSAFPWKEYTGQSPKWIVLWRPEVIVQEFYPDLRSQEIQKIQERLSDLGYYRNITDGYLGSATWHALMDFQAAYDLETSGTPTPETIFWLFSGADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKT3</accession>
    <name>D6SKT3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system core protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD2708</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868426.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2708"/>
    <dbReference type="EnsemblBacteria" id="EFI35294">
        <property type="protein sequence ID" value="EFI35294"/>
        <property type="gene ID" value="Dthio_PD2708"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2044924at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010054">
        <property type="entry name" value="Type2_sec_GspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01710">
        <property type="entry name" value="typeII_sec_gspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="12">
        <location>
            <begin position="38"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="145" mass="15992" checksum="99E2090678237CB1" modified="2010-08-10" version="1">MNQTANIKSKNRAGFSLIELIIVMIILGLLASLVGPRLFRHVDEARVSTARSQIELLGTALDSYRLDIGRYPTTEQGLEALRRAPSGVDNWSGPYLPRDIPSDPWGNEYVYKSPGDHGDYDLLSYGADGQPGGEGEDAEIRSWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL09</accession>
    <name>D6SL09_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868502.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35370">
        <property type="protein sequence ID" value="EFI35370"/>
        <property type="gene ID" value="Dthio_PD2785"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZWNQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="10825" checksum="739320AC6B9FC882" modified="2010-08-10" version="1">MDLVVKINIVPEKCRGCRACETACAWWDKPPFNPRRAGIHIIKDEEAGSEYPLLNMECQEKFCGKQAPGAGSLLEPACVTACLFEALQVEKEEVRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL24</accession>
    <name>D6SL24_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">Dthio_PD2801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868517.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2801"/>
    <dbReference type="EnsemblBacteria" id="EFI35385">
        <property type="protein sequence ID" value="EFI35385"/>
        <property type="gene ID" value="Dthio_PD2801"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="548" mass="62159" checksum="9D93E419E7E51CDF" modified="2010-08-10" version="1">MSGLTLSPYWTKLKEHFSRISDIHMRDMFTADPERFSSFSLQAGQIFLDYSKNRIDRETMSLLFGMARDMGLEDKTTAMFSGQKINTTEQRSVLHVALRNRSNRPTYVDGEDVMPQVNQVLDRMKDFVHGVREGHWRGWTGEPVKDVVNIGIGGSDLGPRMAVKALDGFSGPDLRVHFVSNVDPSHLENTLARLDPRTTLFIVASKTFTTQETMFNAARAKDWLLESAKNQEHIARHFVAVSTNTPKVQEFGIDPQNMFGFWDWVGGRFSLWSAIGLPIALSIGMERFEQLLEGAHEMDEHFLNTPLENNLPVILGLLSIWYTNFFKTESHALLPYSQYLEEFPAYMQQGEMESNGKRITLQGAEVDYETGPVIWGAPGTNGQHAFYQLLHQGTRMIPCDFIIFARQPGHDPVQHRLLMANYLAQTEALMLGKTSAQVRQELESQGKSSHEIEKILPHKVFPGNKPSNSIILPELTPRTLGALIALYEHKVFVQGALWDINSFDQWGVELGKQLARKIEPELEDDSEVTDHDSSTNGLINKWKAMYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL28</accession>
    <name>D6SL28_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbbR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868521.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2805"/>
    <dbReference type="EnsemblBacteria" id="EFI35389">
        <property type="protein sequence ID" value="EFI35389"/>
        <property type="gene ID" value="Dthio_PD2805"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="992089at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="299" mass="34191" checksum="269A54BAC8AB0CA9" modified="2010-08-10" version="1">MLKSNWQYRILAVVMAVFFWYLISGQEKVEMWVDVPVEVSHLSEDYTVISGMVSKVTVRCRATKTMLSRMDMARLAYNLDLSGLEQGENTIVLDPKRINLPRAVQAVEITPARLELEVDRIVSRELPVEVVWTGAISPYYELKNKMVEPAALHVRGPEKILKNMDTVKTRPVAVDSDRPDRFQRKAGLDLRPELESTPSDVRVELVFGPVLEDIWVRKPIEVRGAQGVNYSLDPGYVRAYLDLPRELLQEDGWREKIHYYVEKNPGAGPGVHELQVYAELPEHGQVLEMRPEKVEISID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL29</accession>
    <name>D6SL29_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ORF">Dthio_PD2806</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868522.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2806"/>
    <dbReference type="EnsemblBacteria" id="EFI35390">
        <property type="protein sequence ID" value="EFI35390"/>
        <property type="gene ID" value="Dthio_PD2806"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1300262at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="82"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="250" mass="27591" checksum="7CA7E5647494823C" modified="2010-08-10" version="1">MLLDLGIVQIGWRDLVDIAVVAYIAYRVMLFLKGTRAVSVVYGLLILMVVYYVADEFGLYTLHGMLTNFLGSLFLVVIILFQSDIRKALAEMGAGRLWFNPRPTNKVLDELILAAVHMAEKKIGALIVLEKRTPLGDVVESGVELNADFSRELMETIFYPSTRLHDGAVVVRANKIAYAGCILPLAVGVPSRWNFGTRHRAAIGITEESDALAVVVSEEKGMISVAMSGKLIPGLDEVRLRRVLTSAWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLB2</accession>
    <name>D6SLB2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868605.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2893"/>
    <dbReference type="EnsemblBacteria" id="EFI35473">
        <property type="protein sequence ID" value="EFI35473"/>
        <property type="gene ID" value="Dthio_PD2893"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YT2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1922535at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9344" checksum="637E15E8132B32AE" modified="2010-08-10" version="1">MNISPKGVIVDKDRLWVELNDGRTIGVPLAWFPRLLNASPEQLQKYELSPRGVHWEELDEDISIQGLLLGQGDLTLRHREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLC1</accession>
    <name>D6SLC1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35482">
        <property type="protein sequence ID" value="EFI35482"/>
        <property type="gene ID" value="Dthio_PD2904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="67" mass="7082" checksum="B43DFDA152543864" modified="2010-08-10" version="1">MKGSVTTTPGPSLAKAVRDAGDRFFELPFLLNFAKFLSTPATASLPEGPPCLELPDLSETTSLQSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLP4</accession>
    <name>D6SLP4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868734.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3034"/>
    <dbReference type="EnsemblBacteria" id="EFI35605">
        <property type="protein sequence ID" value="EFI35605"/>
        <property type="gene ID" value="Dthio_PD3034"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50347ZV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1597035at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="168" mass="19653" checksum="FF38CA17C0757B57" modified="2010-08-10" version="1">MGMSFFPRSGSGSRRQGSTFRVFLLVLLFVVVGLLFWKNYERSMDVILSSHVVQDETETLSREQKDELSSFAKGLQDRFGFGLQIRVFEHFVEKPEPDSRVIFMGISPANQEVEIVWPPVLRRALPDDFTRHLEEEHFEEYWQGDNWPRGLYQALQRLGEELLAIEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLQ6</accession>
    <name>D6SLQ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">CMP-2-keto-3-deoxyoctulosonic acid synthase</fullName>
            <shortName evidence="2">CKS</shortName>
            <shortName evidence="2">CMP-KDO synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kdsB</name>
        <name evidence="3" type="ORF">Dthio_PD3046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23448"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.7.7.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.38" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868746.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3046"/>
    <dbReference type="EnsemblBacteria" id="EFI35617">
        <property type="protein sequence ID" value="EFI35617"/>
        <property type="gene ID" value="Dthio_PD3046"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1345588at2"/>
    <dbReference type="UniPathway" id="UPA00358">
        <property type="reaction ID" value="UER00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033468">
        <property type="term" value="P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00057">
        <property type="entry name" value="KdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="252" mass="28609" checksum="E30083EB02ADDB4A" modified="2010-08-10" version="1">MRHRDNNSLVFTGIIPARYSSTRFPGKPLADILGKPMFWHVYQQAVQCRLLHRVYLATDDERIYQAAGELRVPALMTSPEHHSGTDRIMEAARQLGLARQSVVVNIQGDEPALEPKILDQLLEPFVSATGVCVTTPARRIDFQEAQSPNTVKVVISQRGRALYFSRSPIPWSHDGEGPFLGHIGLYAYRYDILEKFQQMEQSFLEQTEKLEQLRLLEAGIPIDVVVTRYACHGVDVPEDISRTVQLLQERQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLT4</accession>
    <name>D6SLT4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3074"/>
    <dbReference type="EnsemblBacteria" id="EFI35645">
        <property type="protein sequence ID" value="EFI35645"/>
        <property type="gene ID" value="Dthio_PD3074"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="14106" checksum="3430907E1389BC15" modified="2010-08-10" version="1">MMPVQAGINALLGAQIKSPIMAAAVSFTVGAAFLILLCIMLRIPAPAMSLWGKLPLWMWTGGLLGAFFVTTTIILAPKLGAVTLLASLITAQMTASIILDHYGLIGYPVQPVNMGRVLGVIFLILGVLLVQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLT9</accession>
    <name>D6SLT9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3079"/>
    <dbReference type="EnsemblBacteria" id="EFI35650">
        <property type="protein sequence ID" value="EFI35650"/>
        <property type="gene ID" value="Dthio_PD3079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="49" mass="5361" checksum="5DDEAB9FD1FD4DC8" modified="2010-08-10" version="1">MVTTLKTVAPGQGTELKEFNMKEGLILFLKVMAVPIIAITVVLILIFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM29</accession>
    <name>D6SM29_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868869.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3169"/>
    <dbReference type="EnsemblBacteria" id="EFI35740">
        <property type="protein sequence ID" value="EFI35740"/>
        <property type="gene ID" value="Dthio_PD3169"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547060at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="387" mass="43109" checksum="A23188ED73A17102" modified="2010-08-10" version="1">MSLLYLDLECGISGDMFVSALSDLGVDFTPLEEAFNSLELGVKMKFAGDSRNGITGKRADFSWESDQPLRLMRDIHDLLERLPVSESVKSGSRHAFERLARVEAFVHGMDVDKVHFHEVGALDTLMDIVGAFWGLESLGVSRVWASSVPWFSGKVQTAHGELPLPAPATAVLLENKKIKPSGYDWEIITPTGALILDQLVQEYTTGFPGILKKSGTGFGEKQAGFNGLRIFLAEMEENPDKYGQDKVWVLTTNIDHLTGEELGFLLENIMQAGALDVIHLPGTMKKNRPGCQVQVMCRPHELKSIQEAFFRHSLTLGLRVQLQERIFLPRRSTQVKIKNQSIQAKEVFFDGRTYVRPEMNDLSGLADKCKESVVQIRLSGEGDAEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM51</accession>
    <name>D6SM51_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35762">
        <property type="protein sequence ID" value="EFI35762"/>
        <property type="gene ID" value="Dthio_PD3193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="83" mass="9102" checksum="B14F08322352453D" modified="2010-08-10" version="1">MDLTVLTTSVSAIYIFSITHPDYQDDKLLVPNFNNNPVAPHPIFPESGQVLAQGVAVYPGIFSRSYTVQEIRPNISLALTVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM76</accession>
    <name>D6SM76_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-viologen-reducing hydrogenase delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3222"/>
    <dbReference type="EnsemblBacteria" id="EFI35787">
        <property type="protein sequence ID" value="EFI35787"/>
        <property type="gene ID" value="Dthio_PD3222"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003813">
        <property type="entry name" value="MvhD/FlpD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02662">
        <property type="entry name" value="FlpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="643" mass="69816" checksum="96BB502690F29A1D" modified="2010-08-10" version="1">MKINAMPPCQAKCPIHMDVQGYVAAIARGDVQEADRIIRRTNPFPSVCGRICTRECESVCRRGKSVDEPVAIRALKRFASDSASVGSEVPGPEVRFSEKIGIVGAGPAGLTAAHDLALMGYSVTVFESEDEPGGMLTRGIPRYRLPLDLVRSEVDRIRSLGVEIKTGYMLGRDIFLQDLQKDFDAVFLGMGSEKSTCPECSGMELSGVWTAVEFLKDVSRGKKFNPGNKVIVIGGGHTAIDAARTCLRLGAKDVTIAYRRTIDEMPAGMDEVEDAREEGVRFEFLTAPEAFEGSGKVEKMRCVRMDLDKSCGGKGKLTCVEDSAFEMEADTIILATGYAPRTEAVQELCTEGGDRLEIKDAAGATRTSGVFAGGDFVSGPTTVVQAIASGRKAADAVHRYLRGMDQSPEEQEEVLEDLDDDVARLVPEAGREKPVCLDPGSRVHSFDEVEHAFTPEQARAEASRCLHCSLGAHVSQDCAVCLNCVLVCPYNVPRPGEEKAVIDMSQCQACGICAGQCPAAAIDLGLEPRTELRQNIRRVLEKAESSSPGDFSFAYVCDFSKSRPGDVQGENVYTITRPGLGRIDVYELLVPFEAGAREVLVSGCGEEDCKFKDCSLWTRRNVQRASRVLQSIGLEPERIRLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMB5</accession>
    <name>D6SMB5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868955.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3262"/>
    <dbReference type="EnsemblBacteria" id="EFI35826">
        <property type="protein sequence ID" value="EFI35826"/>
        <property type="gene ID" value="Dthio_PD3262"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1433145at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007296">
        <property type="entry name" value="DUF403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04168">
        <property type="entry name" value="Alpha-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-E" evidence="1">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="38170" checksum="106568CB983DE6D7" modified="2010-08-10" version="1">MLSRAADAVYWMSRYLERAGNIARFLDVNWHLTLDVQDQYLDQWMPLVVTTGDYKDFQARYQEESKEGCIYFLTADPVNPNSILSCARAARQNAIFVRDILPADMWEAINVLYHQVQHACERPETIQMMPNSFCADVKWRSLTIGGIAWETMSHNEPWRFFRLGALLERADKTSRILDVKYFMLLPSINHVGSTLDYIQWGALLKAVSGFQAFRHDYGRIVPEKVAEFLILDRVFPRSILYCLSQAQSCLHDLTGNNLGRFTTSAERYLGQICSSLSYKTIQDIFDQGLHEFTEELQMKMNRLDTAVFDTFFSLWPGVQQEVVQEQINAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SME5</accession>
    <name>D6SME5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ORF">Dthio_PD3295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868985.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3295"/>
    <dbReference type="EnsemblBacteria" id="EFI35856">
        <property type="protein sequence ID" value="EFI35856"/>
        <property type="gene ID" value="Dthio_PD3295"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1522718at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="254" mass="27111" checksum="4BCB7D6E8EF732DF" modified="2010-08-10" version="1">MKTVKIMPCLDMKEGRVVKGVNFVNITDAGDPMEHAAFYQRQGADELAILDISATQENRKTRLEWVRSVSSVISIPLTVGGGISSLDDIKMVLDAGADKVSMSSAAVKNPELIDQAAGECGSHRVTVALDGRRNPQMPSGFELVVSGGTRPVGRDAVAWARECQDRGAGCLLPTSMDGDGTKNGYDLEFTRAISDAVDLPVVASGGAGELEHFYQGVVDGGAQILLAASVFHYRTLSITEVKKYLQQKGLQVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMK8</accession>
    <name>D6SMK8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869047.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3360"/>
    <dbReference type="EnsemblBacteria" id="EFI35919">
        <property type="protein sequence ID" value="EFI35919"/>
        <property type="gene ID" value="Dthio_PD3360"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1455330at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018687">
        <property type="entry name" value="DUF2177_membr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09945">
        <property type="entry name" value="DUF2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15159" checksum="214912B3002DE9BB" modified="2010-08-10" version="1">MNLYFYIKLYLITVPFFFAVDLIWLGLVARNFYQKHLGFILSPEVNWAAAITFYLIYIAGIIFFAVIPALERDSLATALIWGGLFGFFTYATYDLTNMALIKGWPLRVVVVDIAWGAVLCAVVAALSFKAAGWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMM0</accession>
    <name>D6SMM0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3373"/>
    <dbReference type="EnsemblBacteria" id="EFI35931">
        <property type="protein sequence ID" value="EFI35931"/>
        <property type="gene ID" value="Dthio_PD3373"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="11619" checksum="1EA0E54B7BA62777" modified="2010-08-10" version="1">MTTMKRQPSHPGYILKKDYLEPLNISITGMSETLGVSRKTLSKILNGRGSVTPDMALRLSRALNTTPRLWLNLQNSYDLWHAEHLSSAWKDVRPLTSQALNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMW5</accession>
    <name>D6SMW5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869154.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3468"/>
    <dbReference type="EnsemblBacteria" id="EFI36026">
        <property type="protein sequence ID" value="EFI36026"/>
        <property type="gene ID" value="Dthio_PD3468"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="285" mass="32259" checksum="0ED4088941C7D25B" modified="2010-08-10" version="1">MNQEQGQNFLHSLTRVKDDLPVSPAILREIFYKTEHSSSFSLDSISRTVASDQSLTTKVLSRANSAYYGFEARISSVSRAVALLGLSDLRRIILSISVGALSRKVRHQDLDLQVYWEHQSFTALMAREAAIMLGRRDAEDLMTCGLLHDLGKIITALYAPRVWAEIDAQARQEQRAHYLVETQYWGIDHALIGAMVLQLWHLPESLTEPVNWHHRPEFAPSEFRDKARILCLANNMEHSIRADSLHDIDQDLHQVLGLNPGDTRNTAMDIIAGNTMQELKEMFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMZ7</accession>
    <name>D6SMZ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869186.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36058">
        <property type="protein sequence ID" value="EFI36058"/>
        <property type="gene ID" value="Dthio_PD3502"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YWZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1093245at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029470">
        <property type="entry name" value="PDDEXK_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14281">
        <property type="entry name" value="PDDEXK_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="45276" checksum="4B05A75D83BE96A8" modified="2010-08-10" version="1">MNIFKVIASGHGSFQETNASAILAWLLHPEMEHGLGYTFLSRFFNEIKSYDNNEIKSSDNSELNDLAEKLNHKFRGELENKNNLWLDLEFDVNTSVIDIIIVFENWVFAIENKIYSSSFSKGQLEKEYKGLKTQEKFKNKKIVLIYLVPVGEDSETNEENFAKEFDGLSVDGQDFKRLITWQKNQIVNVGSISEVIHTVLRDEFSGTIDPIPEYTRHTLKALLSFISNDFNGYAYEEKQSHSGLNPLTEYKLEYDKLKQMSSGFVGVGNGIRGLLRMDGNDIKSYKYQYTSHNMENKKNWMPIDVFKKLASWKLGASTPDIKWQGKFPADILYKISKDYRSTVFIGIQGGENALNSMSSSDIKNKEWQVGTEKVSSHWIPGDKFKEILDEKHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN52</accession>
    <name>D6SN52_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1526</name>
        <name evidence="2" type="ORF">Dthio_PD1548</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869508.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1526"/>
    <dbReference type="EnsemblBacteria" id="EFI34178">
        <property type="protein sequence ID" value="EFI34178"/>
        <property type="gene ID" value="Dthio_PD1526"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34198">
        <property type="protein sequence ID" value="EFI34198"/>
        <property type="gene ID" value="Dthio_PD1548"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZGFC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077740at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="7589" checksum="86013E696227C57A" modified="2010-08-10" version="1">MHVFADGISKVTLSNGNLRIMLTQRGADDSTVEAGTLIIPASQANNFMNGLANSLKELDSKLKEAREQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN57</accession>
    <name>D6SN57_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869513.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1531"/>
    <dbReference type="EnsemblBacteria" id="EFI34183">
        <property type="protein sequence ID" value="EFI34183"/>
        <property type="gene ID" value="Dthio_PD1531"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="35521" checksum="64CF63E7123770E2" modified="2010-08-10" version="1">MPRIARFIRSDQATVYHVISRTALSGLPIKDTDKDYLLGLIKRLSRLYFVDVLGFAVMGNHFHLVARMHPEDEISNSDIIKRWQDYYGDKVEMPTDRMAEVKKRLCSLGAYVKDIKQNFTRYYNKKHRRQGFFWGGRFKSMIVQEGSTLVNLLAYVDLNPIRAGIVKKPENYRWSSLGYHTQTGNKDGLLDIDFGLKEWNELDPKEIVRKYRQFVYETGAVDAGKGKTIDQKVVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDTRKFTPVGGVEGLYSMKRLGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNE9</accession>
    <name>D6SNE9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869603.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1626"/>
    <dbReference type="EnsemblBacteria" id="EFI34275">
        <property type="protein sequence ID" value="EFI34275"/>
        <property type="gene ID" value="Dthio_PD1626"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1941334at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="103"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="24687" checksum="D416CA21F0493C8F" modified="2010-08-10" version="1">MHQNNDAHISLFSLPGAEENQAGKSSWAVPWSDLMLVMFILFLVLFVFHTRETLVRVPVNQDGHWNQAVQNQSSSLQLQGLYTQAREKLSTPGAPVSVKMTEQGSVLISLFGEVFFSPGSADLNPESNKYLQQIAEIVSLAQGQVKVAGFTDSRENSVQGDRSIFEISAMRAARIGEELTRSRGLRQENLVIQGHGTPRPQVPENSPVGSEMNRRVEIRIVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNG3</accession>
    <name>D6SNG3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylated-DNA/protein-cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1640"/>
    <dbReference type="EnsemblBacteria" id="EFI34289">
        <property type="protein sequence ID" value="EFI34289"/>
        <property type="gene ID" value="Dthio_PD1640"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="156" mass="17518" checksum="EEC9017CF6251990" modified="2010-08-10" version="1">MQEFLIHPEFTLTLIWKNNLIEKTLLQPADSGTTSCMKTSPRPSRALGNLYRHYLNREPLHPEIPLAWKNMPPFRARVLRTLFWLVPWGRIMTYSGLAAMAGNPGAARAVGTAMACNPWPVIIPCHRVIRADRGLGGFSCGTELKKKLLALEDIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNI0</accession>
    <name>D6SNI0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside recognition domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869634.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1657"/>
    <dbReference type="EnsemblBacteria" id="EFI34306">
        <property type="protein sequence ID" value="EFI34306"/>
        <property type="gene ID" value="Dthio_PD1657"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1173565at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038880">
        <property type="entry name" value="MJ0871-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38139">
        <property type="entry name" value="PTHR38139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="35588" checksum="DE62DA39A14DEA6E" modified="2010-08-10" version="1">MFTLYELWSGLGFPLLKICVFIALGVFVGNLIESMNWTRFMARLAAPLTRMARLRDVSGASFSMAFFSGITANTMLAEAYSQEKLTYRELVLSNLFNSLPTYFLHLPTTFFIMVPLIKAAALPYLLLTIIAALLRTLVVVVLGRFILSPKPEPCVECQLPGEGKLNWTEVLARVWKRFKFRFKKIIIFTVPIYTLFFILQQAGFFDWVEESMAEYVHFMAWLSPQALSIVVLQLAAELSAGLAAAGAMLDSGALGVREVVLALLTGNILSSPMRAIRHQLPYYAGIFNPKLAVKLIFYNQSLRVGSLILVGALYYLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNX1</accession>
    <name>D6SNX1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869769.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1806"/>
    <dbReference type="EnsemblBacteria" id="EFI34447">
        <property type="protein sequence ID" value="EFI34447"/>
        <property type="gene ID" value="Dthio_PD1806"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2095098at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="13950" checksum="74BAA1F37024615C" modified="2010-08-10" version="1">MTQITSAAGPPASFYSLVDKKTCPAEKTEGMTRVKSTQKSMGFKWKNISLEYTSEKIELPKPPQGLAPEQKFVHAMHEAGDVHRLSSNDPQAFNPGTSDPGTASRAYQKQKNMDLAPPRPPMLQAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNY1</accession>
    <name>D6SNY1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869779.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1816"/>
    <dbReference type="EnsemblBacteria" id="EFI34457">
        <property type="protein sequence ID" value="EFI34457"/>
        <property type="gene ID" value="Dthio_PD1816"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="71"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="273" mass="30822" checksum="A0F1721BF5C1DB11" modified="2010-08-10" version="1">MLKFFGTALGVAAVIYLIFLGYAYIFQSRMVYVPHQELVASPGDIGLDYQEVYLDTPDDVLVHGWFVPAKEEKGVVLFCHGNAGNISHRLTTLDFLHSLDMSVFIFDYRGFGKSSGSPDEEGTYTDVQTAWNHLTREKGYDPGEIFIMGRSLGGAVAAELAVHQKPAGVILESTFQSIPELGRDLMPFLPVKLLARYSYDTRSKLQDFSAPVLVIHSPQDEIVPYRHGRALYSEALEPRYFLEIQGDHNSGYKESRESYLDCLEKFFRRYKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP02</accession>
    <name>D6SP02_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869800.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1837"/>
    <dbReference type="EnsemblBacteria" id="EFI34478">
        <property type="protein sequence ID" value="EFI34478"/>
        <property type="gene ID" value="Dthio_PD1837"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="241"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="371" mass="41043" checksum="ADDB162D24A0B6D9" modified="2010-08-10" version="1">MLKVHIQTRSIEDNFAFLSRRTTARVMAVVKADAYGHGLEETARCLHQAGADRFGVGSVQEGARLRDCLDAPEIYSLLGPVSPEDYHLLARHRIIPFIHSREQLKALQEASCSFRGTIPVAIKLETGMNRLGFRGGDLHELLETWEKCRGLKLHMLASHLSLADSVQGRQEVLRQLKTFEDYCRTMQARGHEFEKSLANSAAILAHPETHLDCVRPGISLYGDNPFEHTPWASKGEGLAQAMHVRAPVLAVHHLEKGAGVSYGLCFTAPRDMRIAVIGCGYADNYSRGLSNRGWMLYQGRRMPVLGRVCMQLSVVDASHAGDIAPGCEVYVLGGEGRQLLSAREMAGWLDSISYEIFCSLGKNPRTYSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP12</accession>
    <name>D6SP12_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion transport 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869810.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1847"/>
    <dbReference type="EnsemblBacteria" id="EFI34488">
        <property type="protein sequence ID" value="EFI34488"/>
        <property type="gene ID" value="Dthio_PD1847"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="367769at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="132"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="262"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="354"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="481"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="567" mass="63352" checksum="6922F513F38F7C66" modified="2010-08-10" version="1">MKFIPSIVAYFFEDKTAKNNILALLKFLLVLVGMMVLYTLAFHGLMVMEGQEHTILDGLYWTAVTMSTLGYGDITFHTDLGRMFSVLVLLSGVIFLLVMLPFTFIRFFYAPWLEAHNKARTPRELQKKTTGHVLLSNFDPMIANLVEKLKQYNYPYCILVPDQQRALELHDQGYRIMLGELDDLDTYRKARADKAELVLFNNDDHTNTNAVFTLRELSQSTQVIATAETLESLDILQMAGASQVHQFPVMLGQALARRVLGVSMHANVIGRFGDLLIAETPVMRTPLEGKKIIESRLRETTGVNVVGIWERGSFKIPHPDMRIGSNTVLVLAGSQEQLEKYDEIYGIYNLSFDPVIVLGGGRVGRAAADALAENDIDYRIVEKSSRIVASKEKYILGNAADFHTLKRAGIDKAPSIIITTNNDDLNIYLTIYCRKLRPKMQIISRATRDRSVSKLHQAGADLVMSYASMGANSVINYIKGDNVLMVAEGLDIFREKVTGNLHDKSLEQSNIRMKSGCSVIAIDSSGRGTIINPEPDTRLQDGDELILIGTSEAEKKFLCTFKNGNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP13</accession>
    <name>D6SP13_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0965</name>
        <name evidence="5" type="ORF">Dthio_PD1848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869811.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0965"/>
    <dbReference type="EnsemblBacteria" id="EFI33630">
        <property type="protein sequence ID" value="EFI33630"/>
        <property type="gene ID" value="Dthio_PD0965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34489">
        <property type="protein sequence ID" value="EFI34489"/>
        <property type="gene ID" value="Dthio_PD1848"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="385681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025639">
        <property type="entry name" value="DUF4338"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038215">
        <property type="entry name" value="TN5-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003201">
        <property type="entry name" value="Transposase_Tn5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014737">
        <property type="entry name" value="Transposase_Tn5-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014735">
        <property type="entry name" value="Transposase_Tn5-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02281">
        <property type="entry name" value="Dimer_Tnp_Tn5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14236">
        <property type="entry name" value="DUF4338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14706">
        <property type="entry name" value="Tnp_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4338" evidence="2">
        <location>
            <begin position="60"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DNA_bind" evidence="3">
        <location>
            <begin position="296"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Dimer_Tnp_Tn5" evidence="1">
        <location>
            <begin position="649"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="754" mass="86456" checksum="F65104D4D8C2B263" modified="2010-08-10" version="1">MYISGQYFSKDTLNWVQATINEQPSMSMRELSRLVCQKLDWRAANGNLCQVSCRKTLAELNRRNILELPQKEQFYDFQQKKAASNNFEPPNVDCTLDQLGEVNVYPVASRYSKDSKLFFHLLEQYHYLGNGSLCGAQMRYLIHSSTYGHLGALAFDSASWAVKARDKYIGWSEAARRTNLHQVLRNARFLILPTVQVCNLASYVLSIALARLPQDWEQRYNIRPVLVETFVDPGRFSGTCYKADNWTLLDNQTAGRRDGVPKNIFLKPLCSNWREVLCREPQKKLGEIPLPEEPENWAEYEFGAIRLYDDRLKQRLFNIAQDFFADPEGDIPKASGSKARTMGAYRFFQNPRINMDVILDAHKEATVERIKEHPVVLAPQDTTTLNYSAHPMTSDLGPICTSEDTLIGLLLHDTLAFTEEGIPLGVLDAQCWARDPEDEKKRERRKELPIEQKESIKWLRSFEKVCEVQKLCPDTKLVSIGDRESDIYELFSSALEDPQAPRLLVRAEKSRNRQLHDDSLWEYVFKQPVSGSLKIHVPRSGSRKARDTWMDIRFTQVTLKPPKRLNKHGPATVWAVYVLEQEHSDPIEWMLLTTEEVPDFQTAKRCVNWYANRWGIEVYHRTLKSGCRIKNRQLGTADRLQACLGVDMVVAWRIYHLTMLGREIPDVPCTAFFSDAEWKALCCYVYKTSTPPEEPPSLQQSIYMVAGIGGHLGRKGDGPPGTQTLWRGLQRLDTATEMYTIMNPQAYPNMPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP37</accession>
    <name>D6SP37_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase IS21/IS408/IS1162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869834.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1878"/>
    <dbReference type="EnsemblBacteria" id="EFI34513">
        <property type="protein sequence ID" value="EFI34513"/>
        <property type="gene ID" value="Dthio_PD1878"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="362657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="111"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="491" mass="56709" checksum="3A4A8D643401CC2C" modified="2010-08-10" version="1">MIDYELYARIKHYHEQKGLTPAQIAKELQLDPRTVGKWLEAKQFHQRKSVTRPSKLDPFKDTIVRMLEEHPYTAVQVLRSIKEQGYTGGSSILKEYISKVRPKRSRAFLSLAFAPGECAQVDWGNHGSIQVGDSRRNLSFFVMVLCYSRMMYLEFTVSQSMEHFLACHQNAFDAFGAVPRKIMVDNLKCAVLKHPYGQKPVLNPKYLDFAKHWGFEISACGVRKPHEKGRVENAIGYVKKNLLAGLELPDYRAINHYARHWCRATANVRIHAQTGKKPVDMLEEEREHLLPLPVNTYDIGVLTQVRASSQFRITLESNRYSVPARYAGKRLTLKTYPDRLCIYDGNNLVARHVRSFDKKRDIEDPDHVQEFIVQRRAARDQQLFSRFLALSPRAKDYFFELEKKHLNIKHHVQKIVALSEIYGSEAVSRAMDDAFTYSAFSCEYVANILEQRARTMPAPGALHLTRREDLLDIEVKDPDLSIYDKPKEKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP85</accession>
    <name>D6SP85_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1933"/>
    <dbReference type="EnsemblBacteria" id="EFI34561">
        <property type="protein sequence ID" value="EFI34561"/>
        <property type="gene ID" value="Dthio_PD1933"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="278" mass="31374" checksum="D1864C770583BCFD" modified="2010-08-10" version="1">MLTYVLPVLILVVLFLMNAIRILNEYERGVIFRLGRFLKVKGPGIIILIPVLDKMVRTSLRIVTLDVPHQEVITQDNVTIKVNAVLYYRIMSPQHAVLEIEDYHFATSQLSQTTIRTVCGASELDEILGQREKLNTRIQSILDEQTDAWGVKVTTVELKHIDLPQEMQRAMAAQAEAERERRAKVIGAEGEFQAAKRLTQAAQIISEYPQALQLRYLQTMREMTSEGRNATVIPIPIDLFRGLNPIMSEHAQGATKIDPDNLPEPDVPPDPLSSEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP94</accession>
    <name>D6SP94_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.</text>
            <dbReference type="EC" id="3.5.1.28"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1942"/>
    <dbReference type="EnsemblBacteria" id="EFI34570">
        <property type="protein sequence ID" value="EFI34570"/>
        <property type="gene ID" value="Dthio_PD1942"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088132" description="N-acetylmuramoyl-L-alanine amidase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="7">
        <location>
            <begin position="430"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="594" mass="67940" checksum="6EAB5C62E084B31C" modified="2010-08-10" version="1">MTMSIKKTFFCLLAALLLALCTPGLLPAGMQSAVQDLENLIADDNRNQFRSHWLDLAGRFQQELDESQDGNDKARALYYLGRTYQELGKKSFLPSDFEKAEEFYTRAVREHPDTDFAGRSQYRKAEIHLNHHRDSAQAYLEYLRVVYNHSSSSKKDAAQEVLKELDRKNLEMINGKRASLDLEKVSEPQKSPQVSLEERPLADSRIEEEPGQEQSKTDSRTARLVDIRHWSSDEYTRIVLDLDSQVDYYHKLLKPDEELGTPHRLFIDLEKTRQAEEVTQEENVADGILSRIRSAQHTTDKSRVVLDIDELDDFRVFALENPFRIVVDVYSPDERQVLQTVEGEPDISLDPERAELSSGSLLEQLGLKVQTIMIDPGHGGKDPGAVVGNFKEKDIALRMSKVLGRKLEQEGFDVLYTRTEDVFVPLEERTAMANSQKADLFISVHANAHRNQNVRGFEVYYLNFAQDEDAKRVAARENAVSTQKISDLQYILTDLMLSSKISESRDLAKKVHEVTLDNTRGMFSDMDTNGVRQAPFYVLMGAQMPAILLEMGYMTNQKDMRLLQNDDFMQYMARGLTKGVTSYRDKIEQFARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPB7</accession>
    <name>D6SPB7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AzlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869913.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1965"/>
    <dbReference type="EnsemblBacteria" id="EFI34593">
        <property type="protein sequence ID" value="EFI34593"/>
        <property type="gene ID" value="Dthio_PD1965"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1866750at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="26169" checksum="544598A82C8B1D86" modified="2010-08-10" version="1">MHDSDQTTYKEPVVLTRRGMARGFMKCIPLGLGVFAYGLVFGVLAVQAGMSPLQAQIMSLTVFAGASQLMALELWSAHLPVLAITATTLAVNLRHLLMGAAMRDWLVRLPPSRSYLSVFFMTDESWALSVREMAEGKKDAGFLLGAGLCIYMFWNASTGVGATMSSLVDRYFADPAVLGLDFAFTAVFIALLIFFWRGRSQIPVWLVAGAVAWIAFMLFPGKWYIILGGLAGGIVGALRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPD1</accession>
    <name>D6SPD1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1979</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869927.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1979"/>
    <dbReference type="EnsemblBacteria" id="EFI34607">
        <property type="protein sequence ID" value="EFI34607"/>
        <property type="gene ID" value="Dthio_PD1979"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019879">
        <property type="entry name" value="Ammonium_transptr_marine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03644">
        <property type="entry name" value="marine_trans_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="16"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="418" mass="43650" checksum="AC633AFC4DFEDDEB" modified="2010-08-10" version="1">MEGLLELSYALDTFYFLLSGLLVMWMAAGFTMLESGLVRSKNTVEILTKNVALYSIACIMYMLVGYNIMYGDGSSVIPGISFLIGGDNTVAQVVGGGDDAPYYSDISDFFFQVVFVATAMSIISGAVAERMKLWAFLLFAVILTGVLYPVHGYWTWGGGFLDELGYADYAGSGIVHMAGAAAALAGVILLGARKGKYGPGGKVNAIPGANMPLATLGTFILWMGWFGFNGGSELKVSDVESANAVAMVFANTNIAAASGLVVALIVSKLWFGKADLTMALNGALAGLVAITAEPSLPPMILASFIGAVGGAIVVGSIVALDKFLKIDDPVGAISVHGVVGVWGILAVLLSNPDATIGGQLAGIGVIFAWMFGTAFIVWYAIKAIMGIRVSEEEEYEGLDMADCGMTAYPEFVGSKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPD7</accession>
    <name>D6SPD7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulf_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1985"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0711">Selenium</keyword>
    <keyword evidence="9" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="171" mass="18255" checksum="3D55FBD9BE53C43C" modified="2010-08-10" version="1">MPKSTAWSPYLAGALSGLVVILSVWIAGQYFGASTSFVRAAGMIEGLIAPERLEQLEYYVQVAPQVDWQWMFVTGILVGSFIAARTSGSFKVQWVPDMWQQNFGFTPVKRGLMAFAGGAVAMFGARMADGUPSGHGLSGTLQLSVSGLISLIFFLGAGIIMARIIYGGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPD8</accession>
    <name>D6SPD8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869934.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1986"/>
    <dbReference type="EnsemblBacteria" id="EFI34614">
        <property type="protein sequence ID" value="EFI34614"/>
        <property type="gene ID" value="Dthio_PD1986"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1434896at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="281"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="341" mass="40832" checksum="2858823F95A48271" modified="2010-08-10" version="1">MYLAWKEQNKKRYYVIRQSVLSQGVYVSRDLMDLGHDPSVFLEYPGGRSFYIHEQVEEQLNASGTAWDYGDLEDVFWPFVSPDIKRSLQGFKSRDARNARIPELTHQEDEFIRNRLHIIDKRRYNYLRLGELDQSKLTRIPTKFYRPLAFKSRDELEHLFINMEGSLNPSEYSLYVYSFFYLRRFFDEIIAGKMPQGLDQHRLDRLFLQEVCRLDRDVSFWKGHARKKGLHKYLRRYVIMYFDYPFSTGNILQEHIRDFMARNRAGFEQPRPAKKEPGMEEVGTILGMSVQKLKKMSMRELTRIYRRRALKMHPDKGGDHEEFIRLNEAYQTLLKKIRPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPS2</accession>
    <name>D6SPS2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34748">
        <property type="protein sequence ID" value="EFI34748"/>
        <property type="gene ID" value="Dthio_PD2121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="165" mass="19243" checksum="7E834A3E48AB52B8" modified="2010-08-10" version="1">MLFFGVHHSKLKSAMILNILVKGDIERRGEPYFGGISRSTQYIHGHCYAKVDNRDWIDELLEISTVRLPLNWYFVPGTGKDELFGTVVMPNNIESDMMLATLAERHSLIFVGNYEYISFNRKYSENRITYMTYAIRNTVIPSHFSDEKRKEFIRNKALRAFSAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPW8</accession>
    <name>D6SPW8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870110.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2172"/>
    <dbReference type="EnsemblBacteria" id="EFI34794">
        <property type="protein sequence ID" value="EFI34794"/>
        <property type="gene ID" value="Dthio_PD2172"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="15"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="600" mass="67685" checksum="BB8E379C273E0DE0" modified="2010-08-10" version="1">MTAITNTFSTDQPFLSELLSAASSGSIQLPDFQRGWVWDDNRIKAIIASVSLGYPVGALMCMETGGEGVRFSPRPFEGVSISNTSPSELMLDGQQRITSLFLSLKSQFPVLTTNEKKQEIKRYYYLDIKKCFDPDIDRFDAIVSVPEEKVVTSDFGRKVDLDLSSTDKEIENEIFPLNIIFDGNKSDEWQMRFQEYYDFDKEKIKFLFRFKSEVITPFQKFKIPVIKLLKDTPKEAVCQVFENVNTGGVSLTVFELLTATFAADDFRLRQDWDKRRAVFDSTDPVLKHLDEKDFLTAVTLLSSYNKHISKGSSISCKRKDILNLTLSDYCSCADDLQQGMIRAAKFLHTQKIFDTKNLPYQTQLIPLSVICSILGNGFENSAARNKLSQWFWCGVLGELYGGANETRYALDVQNVPAWINGGSEPVTVRDAGFYPTRLLSLQTRNSAAYKGIMALLMKAGSIDLINGDPIETTTYFDQAVDIHHIFPRSYCIKQQYERRFWNSIINKAPLTSRTNRIVGGKAPSSYMASIVKNHGISSHNLHNHIETHLINPALLEVDDFTGFISDRAKKLLDLIQAAIGKSVTGRDSQEVVQEFGGHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ29</accession>
    <name>D6SQ29_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870169.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2246"/>
    <dbReference type="EnsemblBacteria" id="EFI34855">
        <property type="protein sequence ID" value="EFI34855"/>
        <property type="gene ID" value="Dthio_PD2246"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15026" checksum="7550391FA22C4D31" modified="2010-08-10" version="1">MLYMLDTDITSYLIKGQSPDLEARLKKILPARICISVMTRAELKYGLKRLPADHRLHLAVHHLLKIVRILPWDVEAADWYAGIRYQLVSTGQPIGELDMMIAAHSLSAGAALVTNNVRHFQRINAPLILECWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ99</accession>
    <name>D6SQ99_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type IV pilus assembly protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2316"/>
    <dbReference type="EnsemblBacteria" id="EFI34925">
        <property type="protein sequence ID" value="EFI34925"/>
        <property type="gene ID" value="Dthio_PD2316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019169">
        <property type="entry name" value="PilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01175">
        <property type="entry name" value="pilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="354" mass="39742" checksum="8427860977958090" modified="2010-08-10" version="1">MQKKTMFNFLQTKNPSCSLDLGSTWAKTVRLARKGREPQLDRVARIVWSAAEHKDFQSKGRRIKEAWGQLGLKDKSVISSLAGHSVIVKRVFLEKSDSGDLESKINEEAGQYIPFDISDVHLDYHILEPDPESENQEVILVATKKKVVQDLTQVMDHSGLGLSIVDVDAFALSNCFEFNYPELTEKPAYLLDIGGQHSMFAVFWKNQPLFFREMSFGGKQLTDVIASALEVDTSRAEALKLQGPDALSNQDKNRINSECGKVLRTWASEIKRLVSFYQTSVPAVKQAAILQLSGGGSLFQSVGSILEEELQLETRHMDPWKKVEIKSNDFDLKYLESIKPQFCVPTGLALRGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQB0</accession>
    <name>D6SQB0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2328"/>
    <dbReference type="EnsemblBacteria" id="EFI34936">
        <property type="protein sequence ID" value="EFI34936"/>
        <property type="gene ID" value="Dthio_PD2328"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="15673" checksum="62E1EA30C0340579" modified="2010-08-10" version="1">MMDIHRDQDIKNLLQKAVTIAVVGAKDKQGQPVDAVGRYLIQAGYRVIPVHPKRKGVWGLDTYPDLTGIPEPVDIVDLFRASDYCPDHALEVLEMENTPAAFWMQLGITSAQAEEILKDKPIQVIQDKCIMVEHQRLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQB7</accession>
    <name>D6SQB7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870257.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2335"/>
    <dbReference type="EnsemblBacteria" id="EFI34943">
        <property type="protein sequence ID" value="EFI34943"/>
        <property type="gene ID" value="Dthio_PD2335"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025188">
        <property type="entry name" value="DUF4113"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13438">
        <property type="entry name" value="DUF4113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0741">SOS mutagenesis</keyword>
    <keyword evidence="3" id="KW-0742">SOS response</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="424" mass="47902" checksum="44262CBB22BAE9C6" modified="2010-08-10" version="1">MTRMFALVDCNNFYVSCERVFDPSLQDVPVVVLSNNDGCVIARSNEAKALGIRMGAPAFEHREIFEKHGVQVFSSNYSLYGDMSSRVMSSLNRIVPDMEVYSIDEAFLILDSLPQSPESFARDLREKILKWVGMPVSIGIGPTKTLAKIANRFAKKHLEHSGVLDLGSPGMRSTCLELTDVEDVWGIGRRYALLLKSYNVRNALQFSRQSRDWVQSRMTVEGVHILLELQGIPCHFLDRTPRPNKTIISSRSFGRCVETLQELQTALACYVTRAAQKLRHQGSVCSGVTVFVYTNRFRQDLPQHSPSGTANIMYPTDHTPTLIRHALNALEGIYRPGYSYKKAGVMLTRIEPRARKRPTFFQPGAGREKKEKKLMSAMDHINARWGRNTLQPAETLYAPGDWGIKREKLSPRYTTSWDELPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQB8</accession>
    <name>D6SQB8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S24/S26A/S26B, conserved region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870258.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2336"/>
    <dbReference type="MEROPS" id="S24.003"/>
    <dbReference type="EnsemblBacteria" id="EFI34944">
        <property type="protein sequence ID" value="EFI34944"/>
        <property type="gene ID" value="Dthio_PD2336"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="8">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="15851" checksum="AE49C240D51B387A" modified="2010-08-10" version="1">MSKKSRIMSPRAESPEVLLPEVSALVPAGFPSPADDYLDRTLDLNEYLIHNQAASFFIRVAGESMQGAGILPGDILLVDRSVEPAHNKIVVAVLDDEMVVKRLRYRQGRGVLVPEHPGFRPIEITDAMEAHIWGVVTAVIRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQF2</accession>
    <name>D6SQF2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870292.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2370"/>
    <dbReference type="EnsemblBacteria" id="EFI34978">
        <property type="protein sequence ID" value="EFI34978"/>
        <property type="gene ID" value="Dthio_PD2370"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1072875at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="36456" checksum="6363530514FB04E5" modified="2010-08-10" version="1">MTVITELKEQIKTALPDLDMVIGWERGFDPLHATPLFMRKAQDVERLELGPLAVHNTATYLTGFKGKKVGLVVKGCDSRAVIQLLQEGLIDRENVVIFGFPCQGVVDMVKVQKHLGNTGLVREVQIQDSSLKVKVNGEERDLALKDVLADKCARCRYPNAMLYDHFAGQPIEPHASEDKYQDVEELESLSLEERFQHWEREMHRCIRCYACRNACPMCVCRDHCVAQSRQPQWLTQEDSVREKWMFQVIHAMHLAGRCVECGECQRACPMDIPIMALKRKLNREARELFNYEAGVDPNETAPLLSFKVEEENINERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQF7</accession>
    <name>D6SQF7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870297.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2375"/>
    <dbReference type="EnsemblBacteria" id="EFI34983">
        <property type="protein sequence ID" value="EFI34983"/>
        <property type="gene ID" value="Dthio_PD2375"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032WXJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1947964at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="219" mass="24677" checksum="4B2A87A1A72BF701" modified="2010-08-10" version="1">MTYTAKYPEPYCKDMFGLPVLMLEHEAPEQFSLLLQQGFFMPVPKVCSLREFLCELVGVCGVYTEKSLQTIFLDGSAVDDIDQATIRPGCRLALSAAMPGLVGATMRRDGYFKRMREGISLSSRQEEETDSEQDISFRIQVRLYNAVGRDLAGLFLHQGIILSSSDLMQFFKSRPDKFFSELKSVKFQSSELTVEQGNLESLNIPEGEVFLRVVSGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQG4</accession>
    <name>D6SQG4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fmu (Sun) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870304.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2382"/>
    <dbReference type="EnsemblBacteria" id="EFI34990">
        <property type="protein sequence ID" value="EFI34990"/>
        <property type="gene ID" value="Dthio_PD2382"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="151"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="417" mass="47117" checksum="7843DF13E7D97593" modified="2010-08-10" version="1">MPQASDPRAVALNVVLDALRPGRDLQMVLDRNLDPEMDLRDRSLATELAYGYLRYKGRLDFVLNCFLKSPAGLSGKIRVLMGLAAYEIFFLERIPDYAAVSRAVALTRKRFGSRMSSLVNAVLRKCCRVDAFDPDFFRQDHPGEMLFLSRFYSCPEWVVKLWQKDYGTDMAREYLKQSLQKPAAGVRLAPGEDAGRLDEHYVLQRIGPSILLRDNYPGLEDLEKNKKVVRQSFAGQKTLWELGMGDWKSPVWDMCAGRGGKTMLMSSQGLQVWASDNYLPRLAGLKKELLEQVQVQVFAAQGQSPPLKKSSGTVLVDAPCTGLGVLSRRPDTKWKRSPRDVLDFCRVQKELLAAAANVLPSKGQLIYVTCTLSRQENQEQVTDFLKKHKDFECLQTYGTGADEDLGEFFFGARLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQI0</accession>
    <name>D6SQI0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870320.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2398"/>
    <dbReference type="EnsemblBacteria" id="EFI35006">
        <property type="protein sequence ID" value="EFI35006"/>
        <property type="gene ID" value="Dthio_PD2398"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033IIK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2027783at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="75" mass="8772" checksum="24739A72D3D040FA" modified="2010-08-10" version="1">MLNEKFLSDLEKYIKSGELEEDFEWSSEERRMEILDYLERLMDLAEAADETATRIIFKNTGLGQMFDSGKNDEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQL7</accession>
    <name>D6SQL7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate dehydrogenase family accessory protein FdhD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2437"/>
    <dbReference type="EnsemblBacteria" id="EFI35043">
        <property type="protein sequence ID" value="EFI35043"/>
        <property type="gene ID" value="Dthio_PD2437"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="282" mass="30943" checksum="3EB8398E645BC9D3" modified="2010-08-10" version="1">MVTVECITDLLTPEGDSRIRELVLEEKPVGVVLNDEPVGTAMVMARDLEELAVGYLFGQGLIEPGDKIFDIEVCEQGRINVYAEVTPRPDDEMITTSGCGGTGKIARRLLHEDYPEPADFCISFHEVAELIKRTLAWSSLSQDTHCVHGCGYYSEGAFQVCYEDVGRHNAVDKLMGAILLGRFSPRGAAYTTGRLTSDMVLKCARMGIPVVLSRTAPSSLGLDIARRSGLTLGCYVRPGRVNVFNAPHRIVREGLSDKSDVSDRSDKSDVSDRSNRSDRSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQS0</accession>
    <name>D6SQS0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmF</name>
        <name evidence="7" type="ORF">Dthio_PD2490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870410.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2490"/>
    <dbReference type="EnsemblBacteria" id="EFI35096">
        <property type="protein sequence ID" value="EFI35096"/>
        <property type="gene ID" value="Dthio_PD2490"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="6954" checksum="42385490B1C40D5D" modified="2010-08-10" version="1">MALPKKKTSRSKKGMRRSHDHIPAPNVIYCDCGEASLSHRVCPQCGTYRSRTYIKSTADEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQV5</accession>
    <name>D6SQV5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amino-acid acetyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870445.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2525"/>
    <dbReference type="EnsemblBacteria" id="EFI35131">
        <property type="protein sequence ID" value="EFI35131"/>
        <property type="gene ID" value="Dthio_PD2525"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1823496at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="PTHR30602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="155" mass="17769" checksum="98ADCE3178A6B28C" modified="2010-08-10" version="1">MDKLYLRKARIGDVKSIHGILMNCSRQDLLLPRSYSDLYSHLRDYFVVCDDPGNNIMGCCALSIVWDNLAEIRSLAIVSSIRHMGWGGRLVEACLSEALTLGIYRVFTLTYQTEFFARQGFREISKDMLPQKVWADCLNCPKFPDCDEIAMLMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR57</accession>
    <name>D6SR57_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0496"/>
    <dbReference type="EnsemblBacteria" id="EFI33173">
        <property type="protein sequence ID" value="EFI33173"/>
        <property type="gene ID" value="Dthio_PD0496"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="11801" checksum="A07B85E7804A8B65" modified="2010-08-10" version="1">MNGLVRGINMETIADMLEKRGYDRGYDTAYQEKPKWEKQAELKNAQETLIDVAGDFHGPLPNSLQDKIKAIDSIDNLRTLTRKVYKTQSLEEFTELVNRAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR58</accession>
    <name>D6SR58_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0497"/>
    <dbReference type="EnsemblBacteria" id="EFI33174">
        <property type="protein sequence ID" value="EFI33174"/>
        <property type="gene ID" value="Dthio_PD0497"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="9"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="347" mass="40666" checksum="EC60FD71CFA139E3" modified="2010-08-10" version="1">MSTKRNQAPHEGLFLKIFQNLDNARHFLKKHMSEELQKRFDLNTLRLEPTTYVDEKLKKHYSDLVFSVRLIGYKNQFAKIYLLFEHKSSPDPLTGVQVLKYMALQWLDLQEQHMLVDGKLPPIIPIVIYQGQEDDRNMCSSFHDLVEMPSESFKVYIPDFSFAFFNVRGIDEAKVREKILLKFYVEIIKYQNDPSVKEIPPRLVRGLIESLGHRTALEYIDIFFRYLVKSTGYLTQEDYKKALELLPEGGETIMETLADQWKQQGKEEEREAILLEKPIWERQAELKNAKETLIDVAGDFFGPLPNSLQDKINSIDSIDNLRTLTRKVYKTQSLEEFTELVNRATQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR99</accession>
    <name>D6SR99_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bacteriophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870573.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0541"/>
    <dbReference type="EnsemblBacteria" id="EFI33215">
        <property type="protein sequence ID" value="EFI33215"/>
        <property type="gene ID" value="Dthio_PD0541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="65" mass="7765" checksum="9DC2B1ED0B481063" modified="2010-08-10" version="1">MKEPATLQEKWDALPEWVRKLVGKYKYEWEDLPDEARQAFSSEEGQAKIERAFSEYSKDVHGEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRG0</accession>
    <name>D6SRG0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferric uptake regulation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur</name>
        <name evidence="4" type="ORF">Dthio_PD0602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870634.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0602"/>
    <dbReference type="EnsemblBacteria" id="EFI33276">
        <property type="protein sequence ID" value="EFI33276"/>
        <property type="gene ID" value="Dthio_PD0602"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="143" mass="16715" checksum="9FB2B58BB7F022E5" modified="2010-08-10" version="1">MQDAREQFFQYLAKQKLRFTSQRAIIFDVFWNTQGHISPEELYRKTREQDRSIGQATVYRTLKLLSDAGIAREVDFGDGVARYEPYYGQSHHDHLICKECGKNVEVVDHRIEKLQEELASQHGFTLNEHSMYLYGYCAECSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRH5</accession>
    <name>D6SRH5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870649.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0617"/>
    <dbReference type="EnsemblBacteria" id="EFI33291">
        <property type="protein sequence ID" value="EFI33291"/>
        <property type="gene ID" value="Dthio_PD0617"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="13311" checksum="9CC78C493024D7E8" modified="2010-08-10" version="1">MERVHIEDKGNMLIVDISREMTMEIVDDLKKEFEDLFSRPWQVMALDLSGVAFMDSAGIGFVTALNNRSLQEGRKFCLLNPSEQVIKTLKLVNLWDLFATYPSLEEISRSLNLEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRL8</accession>
    <name>D6SRL8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870692.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0662"/>
    <dbReference type="EnsemblBacteria" id="EFI33334">
        <property type="protein sequence ID" value="EFI33334"/>
        <property type="gene ID" value="Dthio_PD0662"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11961" checksum="672BA0460185C152" modified="2010-08-10" version="1">MSEEKEYLKIGQAAELLELEPYVLRFWESEFPQLRPMRTPKGQRLYTSEHIQLLARIKKLLYQDKLTIEGAKMRLEEEARMAGILANIRDELQQIKDILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS21</accession>
    <name>D6SS21_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="11" type="ORF">Dthio_PD0821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870839.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0821"/>
    <dbReference type="EnsemblBacteria" id="EFI33487">
        <property type="protein sequence ID" value="EFI33487"/>
        <property type="gene ID" value="Dthio_PD0821"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="184" mass="20376" checksum="395DD12F05E7CF63" modified="2010-08-10" version="1">MSGFRNKKGNIYLIGPRASGKTTLAEDIAGRTGLKAVDADKALQEEQGQSIQEIVSGQGWEYFRDLESKFLQRTAGSGPMVVATGGGVVLGSANRELLKDFRHLTVYLQAEADLICSRLAEDPKPGQRPALSDLDFREEIRATLEKRQKLYMECADIVLAADQPLELLAEEVYRVYVDKKQEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS36</accession>
    <name>D6SS36_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="9">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glnS</name>
        <name evidence="13" type="ORF">Dthio_PD0836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870854.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0836"/>
    <dbReference type="EnsemblBacteria" id="EFI33502">
        <property type="protein sequence ID" value="EFI33502"/>
        <property type="gene ID" value="Dthio_PD0836"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="142899at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00126">
        <property type="entry name" value="Gln_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022861">
        <property type="entry name" value="Gln_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="26"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="12">
        <location>
            <begin position="338"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="39"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="563" mass="64835" checksum="9FC91A47F181A30C" modified="2010-08-10" version="1">METAEASHFIQDIIEQDLKSGKHNTVVTRFPPEPNGYLHIGHAKSICLNFGLAKKYGGRCHLRFDDTNPKKEDPEYVHSIIEDVKWLGYDWGEHLYYASDYFQQFYEYALQLIQQGQAYVCSLGPEEIRSYRGTLTQPGRNSPYRERSVQENLDLFQEMKKGSFEEGAHVLRAKIDMASANINMRDPVIYRILKARHHRTGDAWCIYPTYDYAHCLSDSIEGITHSLCSLEFQDHRPLYDWFLEKLGVKCHPQQIEFARLSLNYTVMSKRKLTQLVQAGHVHGWDDPRMPTISGLRRRGYTPGSIRKFCDLIGVAKSDNVVDMSLLEYCIREDLNRRAPRYMGVLNPVKVVITNYPGQSSEELEAINNPEDESMGTRSIPFSGVIYIEADDFREDPPKKYFRLAPGREVRLRYAYFITCREVVRDPQTGEIQEIRCTYDPETRGGDSPDGRKVKGTLHWVSAAHAVQSSVHIYDRLFSRPNPLQDEKKGLGLDDTLNPDSLQKMHGCMMEPAVKELAPGDFLQFERLGYFCVDPESHPQSPVFNRTVSLKDTWAKIEKKMQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS61</accession>
    <name>D6SS61_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsR</name>
        <name evidence="8" type="ORF">Dthio_PD0861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870877.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0861"/>
    <dbReference type="EnsemblBacteria" id="EFI33527">
        <property type="protein sequence ID" value="EFI33527"/>
        <property type="gene ID" value="Dthio_PD0861"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9991" checksum="DE6DC68F795882AB" modified="2010-08-10" version="1">MVYKKFAPRKKFCRFCASKENILDYKNVDMLKDFITDRGKIIARRITGNCAKHQRALTTEIKKARQMALLYYTATHSTDVRKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS80</accession>
    <name>D6SS80_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ORF">Dthio_PD0880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870896.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0880"/>
    <dbReference type="EnsemblBacteria" id="EFI33546">
        <property type="protein sequence ID" value="EFI33546"/>
        <property type="gene ID" value="Dthio_PD0880"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="708179at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="335" mass="38816" checksum="B339E6D659987858" modified="2010-08-10" version="1">MNAKRVLLYLFLLLVLGTGLSAWYFHHLVHSPQSPESSKEIVRISPGQSFKSIAYHLESMGLIDNATVMYYWGWLQGKATKVQAGHFQVDAQWSMQEMLEHLSTGREQLLRLQIPEGAAWWDVARILEKRELASFEEFQGVVKDKDFLEEMGIHASSAEGFLYPETYYISPSRDVGAEKLARIMINQFWKSTSDLWGEMSFDEIYDMVNKASLIEKETGIAPERRKISGVFHNRLESNMLLQCDPTIIYGLGEDFEGRLRRRHLDDRDNPYNTYHHRGFPPTPICSPGRASIEAALDPQEHGYYYFVSRNDGTHHFSKTLQEHNRAVYRYQIMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS94</accession>
    <name>D6SS94_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870910.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0894"/>
    <dbReference type="EnsemblBacteria" id="EFI33560">
        <property type="protein sequence ID" value="EFI33560"/>
        <property type="gene ID" value="Dthio_PD0894"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1691156at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="131" mass="14804" checksum="49441D17AD672A66" modified="2010-08-10" version="1">MDSIGVKSTKREQFLDITREVQEYLSSNKMNSGVLTLYCSHTTAGLTINEGADPSVVRDILVNLERLIPRNGDYQHMEGNSDAHIKSSLMGPSLQLIVDNGRLMLGTWQKIFFTEFDGPRSRKVWLKWTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSJ5</accession>
    <name>D6SSJ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="4">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbiA</name>
        <name evidence="6" type="ORF">Dthio_PD0997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CbiA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871010.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0997"/>
    <dbReference type="EnsemblBacteria" id="EFI33661">
        <property type="protein sequence ID" value="EFI33661"/>
        <property type="gene ID" value="Dthio_PD0997"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692368at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="261"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="4">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="482" mass="53318" checksum="BE07D3FCD1E51815" modified="2010-08-10" version="1">MINGLLHQQSFPRITISGLRGGSGKTIISLALTWLFTQQGFKVKAFKKGPDYIDAKWLSLASGQHASNLDPFLFSTSRIKFFFSSFAGTHDLAVIEGNRGLFDGMDTRGSCSTSELARILESPVLLVLDCTKVTRTTAAIVQGCAMFEENLDLAGVILNQTAGARHRDITRRSIEKYTDVPVLGALPKLKDTPIPERHMGLISSQEYQGQDEIFRALGKVVQDNIDVELVLNIAGTAPACTKTQNHVQEVSSGPPKEEAVIGVVRDRALWFYYQENLDALRQQGAKLVELSLLTPEDWPRIHGLYLGGGFPETSARELSVNVAARQKVKDLADQGLPIYAECGGFMYLAESLHYEGEDFDMAGVFNVQTRVYKKPQGHGYIRAGIIEPNPFYSTGDTIVGHEFHYSRCLSLTPEARFCMRMERGTGMADYKDGLLYRNVLAGYAHVHAFSVENWAVNFVRAAGIFREHVQKSTGPCPDIVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSM4</accession>
    <name>D6SSM4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c biogenesis protein transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871039.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1029"/>
    <dbReference type="EnsemblBacteria" id="EFI33690">
        <property type="protein sequence ID" value="EFI33690"/>
        <property type="gene ID" value="Dthio_PD1029"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="53"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="182"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="390" mass="42265" checksum="31100FB53401611B" modified="2010-08-10" version="1">MQKKGSLLKGLLPGLAFLAVILFMPSGALGSDYEVITSRTVPEPDAVLSGELEKPALVNVGVAACPPCRRMAGDLLELQANYDSIFETHYYDMHKHSGITEKLDIRMVPTQIFLDKEGEELYRHEGYLSRKHILETWADLGYDVQIVVPSRGVRDYLSLDYIFSRLSLAVQGAPLTAMAAAFVWGILSVILSPCHLASIPLIIGYINRRKVETAARATVLSLMFALGILICIMVVGIITAMAGRLLGDLGSLPYYLVAIVLLLFGLNLAGLVPLHWSLVDRLVPKNSSKKGAVFLGLVIGVGLGPCTFVFMAPMLGLTLSLASAEQVFGLLLLGIFALAHCMLLVAAGASPGFLYFFLRWNELSPGSSVLRKTCGVLLILGGIYLFYYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSP5</accession>
    <name>D6SSP5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nif11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871060.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1050"/>
    <dbReference type="EnsemblBacteria" id="EFI33711">
        <property type="protein sequence ID" value="EFI33711"/>
        <property type="gene ID" value="Dthio_PD1050"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2095861at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022516">
        <property type="entry name" value="CHP03798_Ocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012903">
        <property type="entry name" value="Nif11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07862">
        <property type="entry name" value="Nif11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03798">
        <property type="entry name" value="ocin_TIGR03798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nif11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10066" checksum="F45B4FC8BDF947EC" modified="2010-08-10" version="1">MSIQSAKAFLELVQKDTGLHSRLARCRDSMEIMDIAREKGYDFTPDEARMVMEQPCDGVHDRMLEMLVQSLYARSQGHGKKVDSHAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST09</accession>
    <name>D6ST09_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ORF">Dthio_PD1164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42732"/>
            <dbReference type="Rhea" id="RHEA-COMP:10209"/>
            <dbReference type="Rhea" id="RHEA-COMP:10210"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.170"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.170" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871174.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1164"/>
    <dbReference type="EnsemblBacteria" id="EFI33825">
        <property type="protein sequence ID" value="EFI33825"/>
        <property type="gene ID" value="Dthio_PD1164"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="212" mass="24046" checksum="861038DECA63B706" modified="2010-08-10" version="1">MQLEELREETAALGFELNPQQVQGLQAYLSTLEKWNRSVNLVGPSHWREILHSLVVDSLYLSGFLSRIAHQEDIRSLDLGAGAGLPGLPLRLLWDKGSYYLVESRFKRCAFMRQAISAMGIQNTYVINGRVEDLPRDILPADLIVSRAFMPWKKLLALTVSMLDVRGSLIVLSSQEAEGKDLQGFVLKEQFCYQVQGKRRFFWALQKMDDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST13</accession>
    <name>D6ST13_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871178.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1168"/>
    <dbReference type="EnsemblBacteria" id="EFI33829">
        <property type="protein sequence ID" value="EFI33829"/>
        <property type="gene ID" value="Dthio_PD1168"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259346at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="176"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="420" mass="47104" checksum="50EECC41A1BFD26D" modified="2010-08-10" version="1">MPSSKTPHLIYADARGQIYDEPGLLMLVRRGRELALPRPDEMMPLPESSDLFLLPGRKALGLDPETGNVEVMEGLALAGFASPGHTLCATAAYAKEDSAPRLPLYAYGAVGYFRDRFWISAMQVDKDQRQNFCDIPQDKITRGARELLRKYPENRLISHLAGCALNYCCPAARNLALGRFEAPLPTARECNAACIGCISYQPDDSGMQATQARIDFTPSPGEIKEVMLEHCRKEKRPILSFGQGCEGEPLTRARTIIQALQKARQEIPAATININTNASLPEFIPPLARAGMDSMRVSLNSAEPEFYHMYYRPRGYGFEDVIRSISLAREHNMFISLNLLFFPGVTDTEDQMERIAGLVQDHRIDFIQMRNMNLDPDIYLELAGDRALGPGMGLKNFMTRLKKECPWIDFGYFNPCLNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST25</accession>
    <name>D6ST25_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871190.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1180"/>
    <dbReference type="EnsemblBacteria" id="EFI33841">
        <property type="protein sequence ID" value="EFI33841"/>
        <property type="gene ID" value="Dthio_PD1180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10438" checksum="B485F6596311FE44" modified="2010-08-10" version="1">MIKQLYKRVYARRQQLAVFGVNTLAWLLVVMQWRLSQSTALDGEKEKFILLKLSTAEKLCVQPRRSLFTKKITIKGMKSMKLNFRCSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST56</accession>
    <name>D6ST56_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit</fullName>
            <ecNumber evidence="7">2.1.1.132</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.132" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871221.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1211"/>
    <dbReference type="EnsemblBacteria" id="EFI33872">
        <property type="protein sequence ID" value="EFI33872"/>
        <property type="gene ID" value="Dthio_PD1211"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1706318at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046025">
        <property type="term" value="F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="409" mass="45303" checksum="4DF9370D0A76DF7A" modified="2010-08-10" version="1">MPGVQVIGTGLGYEDLTARHLEIIQDSHVLVGGQEQLDWFPGHPGIKRRITSPLDDLIQDIRNWMLDRQVAVLASGDPLFYGIGRRLILDLGADHLEVHPNISVMAGAFARIRTPWDQAAWVSLHGRSHSHLLAALDSGRPLFVFTDPRNSPARAAQILEQNKSAGWSMCVLERLGRPDERVRWFSPAEAADEEFMEPNALILFPAPEKPQEPRVLTLGTPDHFYLHQRGMITKSEVRAVSLAKLGLEPGHVFWDLGSASGSMAIEAAMFTTGGRIVAVEKDPERISHIRENIRRFQTPGVEVLQMDLPEGIQDLPPPDRVFIGGGGEDLPEIIRQTARILKPGGRIVLNLVVFETLHKAVEILNSLDFSTEVIQVQISRGRQMPGGVRLQAQNPVFVLSALPRNVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STD1</accession>
    <name>D6STD1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871296.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1286"/>
    <dbReference type="EnsemblBacteria" id="EFI33947">
        <property type="protein sequence ID" value="EFI33947"/>
        <property type="gene ID" value="Dthio_PD1286"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50338U3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1946967at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10440" checksum="F248F9C139AD1D73" modified="2010-08-10" version="1">MSTPSGMYYYPDPRNKKERMYVRDNEGSIEFRLWNQDQPEIWERHGWLDMDIIKRAAKMYGDKKQDPLKLYDLDIARSLLKQNRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6STD6</accession>
    <name>D6STD6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871301.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1291"/>
    <dbReference type="EnsemblBacteria" id="EFI33952">
        <property type="protein sequence ID" value="EFI33952"/>
        <property type="gene ID" value="Dthio_PD1291"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="157"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="2">
        <location>
            <begin position="336"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="421" mass="48098" checksum="F92FFD54D340DDCC" modified="2010-08-10" version="1">MTRKDRTEGILTRKEVLDQSERQKYYQIQLKDLLSYAYRYSEDVKKRFDRAQFYVDKFKTLGDLKHIPILKKKELIFLQSMGPRLGGLLTKDLGELRRIFLSPGPIFDPEDRTDDYWGWTEGFYATGFRTGDIVQVTFSYHLAPAGLMFEEPLRNIGCSVVPAGPGNTNTQLEVMQKLRVTGFVGTPSYLMHLAQKGEEKGLNLRKDLFLEVAFVTGEKFSEKVRSTLEKKFDLIMRQGYGTADVGSIGYECFHKNGLHVSNRTFVEICHPDTGIPLKEGEVGEIVVTSFNKTYPLIRLATGDLSYIDHSPCPCGRTSPRLGNIVGRVDTTARIKGMFVYPHQVEQVMAGFEEIKRWQIEVTNPGGIDEMTLYIEASSFKREAELLHIFREKIKIRPELQILAPGTLPPQVRPIEDKRTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STG0</accession>
    <name>D6STG0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1315"/>
    <dbReference type="EnsemblBacteria" id="EFI33976">
        <property type="protein sequence ID" value="EFI33976"/>
        <property type="gene ID" value="Dthio_PD1315"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088193" evidence="4">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="421" mass="48719" checksum="F4B6EA553B1BEC4A" modified="2010-08-10" version="1">MRTILFLLLILTWSLPAMAWEPLITGDSRAPEDLFVVDKKNQTFFVFSNKSPLRKEYKWEVTTGEGVGDKEVEGDLKTPEGIYFIERQIDTRHLDRDLYGEMGLTLNYPNPVDRAKGKTGFGIWLHGRGKEVVPFDTEGCVAMDMKYMHRLEDMVQLQNTPVVITSTMSWEEDEIELEKSRKIADLSLDWAAAWSDGTGEYFEFYLPDRFARSSGKSFSSFKNHKQGLFNTYDWMDVYIEQPKVLAGPDYWVSYFGQVFNSSGFFSSGVKRLYWQKDEAGDLRIVGEEFRNYNKPGLKDSYIKDRGQRLKQVVEKWRQAWLEADVDKYASFYHPDAVQGNVRGLDSILKDKKDLWERGNEPAEIEISDIEAHVGRDGFEVRFKQEYASRSGYSDKGIKTLQFVPGSGDSWLILREDWRETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6STG2</accession>
    <name>D6STG2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="5" type="ORF">Dthio_PD1317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871327.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1317"/>
    <dbReference type="EnsemblBacteria" id="EFI33978">
        <property type="protein sequence ID" value="EFI33978"/>
        <property type="gene ID" value="Dthio_PD1317"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="128"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="191" mass="20835" checksum="898F36F7593B44B0" modified="2010-08-10" version="1">MQNFDAKSRLAELLYNKSYQEGNFTLTSGKKSDYYFDCKQTALHPEGAFLLGRIFLDMLYAYEKYPEGVGGMTLGADPLVSAVTVMSYLDNRPLPGFIVRKKAKGHGTGQFLEGMANFSPGQRVCMLEDVITTGGTLLSACERVRDAGLAIGPILCVLDREEGGAENIVRAGFDIKCIFTRQSLLRAAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STH8</accession>
    <name>D6STH8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871343.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1333"/>
    <dbReference type="EnsemblBacteria" id="EFI33994">
        <property type="protein sequence ID" value="EFI33994"/>
        <property type="gene ID" value="Dthio_PD1333"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="27663" checksum="4511810D69E0EDD9" modified="2010-08-10" version="1">MKSILGWLGHQTLGFLQELGRIMVLFLQALSWLVRPPFRIRLFFKQMEFIGVNSLFVVALTSLFTGMVLALQTFYAFSMFGAETLVGATVALSMTRELGPVITGLMVTGRAGSAICAEIGTMRVTEQVDALTVMAINPVQYLVLPRIVAGVIMLPLLTIISNTMGILGGYLVGVQLLDIHGGMFLNKIQEHVTMADVYNGLIKASAFGGILTLVGCYKGFYTRGGAEGVGRSTTQAVVMSSVLILVSDYFLTALMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6STI0</accession>
    <name>D6STI0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase system, phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871345.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1335"/>
    <dbReference type="EnsemblBacteria" id="EFI33996">
        <property type="protein sequence ID" value="EFI33996"/>
        <property type="gene ID" value="Dthio_PD1335"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="404807at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="10621" checksum="0C5DEFE4D6DDCEF5" modified="2010-08-10" version="1">MDMAEENICETTISLHNEFGLHARPAGRIAKAAQQFEARIMIGFDGREVDAKSILDILSLAAPNGSALRIHAQGNDARHAVEHLENIFREKLREDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6STI4</accession>
    <name>D6STI4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ORF">Dthio_PD1339</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1339"/>
    <dbReference type="EnsemblBacteria" id="EFI34000">
        <property type="protein sequence ID" value="EFI34000"/>
        <property type="gene ID" value="Dthio_PD1339"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="214" mass="23266" checksum="0557FFD970627AF9" modified="2010-08-10" version="1">MWVKAYGHPALNLQSGFDPVPPAGLDEAGRGCLAGPVVAAVVVLPLDAQIARLTDSKKITSKVRESLIPEIKSTCLAWSLGLAWPREIDRINILQATMTAMKRAVLHLGLTPGQLLVDGNQKIPLNIPQKCIVGGDMTEPCISAASILAKTFRDMLMTKLDRRYPGYGFGQHKGYGTRKHLQALKSLGASPMHRKSFKGVLPRPREKVPCLPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6STJ8</accession>
    <name>D6STJ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871363.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1353"/>
    <dbReference type="EnsemblBacteria" id="EFI34014">
        <property type="protein sequence ID" value="EFI34014"/>
        <property type="gene ID" value="Dthio_PD1353"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2209766at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="344" mass="40522" checksum="613C65382EF3D124" modified="2010-08-10" version="1">MNKPSFHPSNTIKQILESLDPEHSIVKTIRNKEPRMVMHLKIKGRDCLLKALTTPYPWKKPGRRFRLQKEIFIYNQLNNISLFSFLYPQVLHTDGKNYIITDFIPNNPSLGRNDSLFYNQAVKSIQDLNTCDFPFKTFYCKGWVWERVNRWKCSRSAKTLRNLLEGAVIKGNVPVSSCPRLLSFWAKALFATKQLKKPLLVHRDIFKANILRPEPDKIYFVDFEKAGIEKRWVFVDALKIAQAEPLFFNCNDNKLNGFPRFYKCLLQQYWQGLQTRRTDINPDFHHFKLQLKFCLMGWTLKKLVKENPGPKKAKNLIRFMETVITGDDSCFDKWFSKLPRLPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6STK2</accession>
    <name>D6STK2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871367.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1357"/>
    <dbReference type="EnsemblBacteria" id="EFI34018">
        <property type="protein sequence ID" value="EFI34018"/>
        <property type="gene ID" value="Dthio_PD1357"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="168"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="355" mass="40255" checksum="6C0AC8F840DCA21F" modified="2010-08-10" version="1">MNILFVNTSRIWGGNEKWTHMASHALASRHNVLLVYRCPYLGSRFSIKKMKLPFINRVDLFTLYCLKKIIQREHIDILISTNRKHYLLGVLASKITGCRHFVRCGIVWNVPDNIYNRFLFREIDGIIVNARAIQDMLIKSGVVRKDKIHVVYNGLDTDILDKSKLKYKSRDEFVIISSGELVPRKGYIFLLHAFAKFLKMQPDSNVQLILIGKGRQEQELKSVAKKLGIEQQVTFAGFLDDPYSLIIQSNLFVSVSQNEGISNALLEAMYLGIPVVTTPAGGSLEVISHGENGFLIKNSSEKYLADIFRQAYLNSSLFQDIGRAGQSTVKSKFSLASMSSHLENIFKSYLGRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6STN8</accession>
    <name>D6STN8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871403.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1393"/>
    <dbReference type="EnsemblBacteria" id="EFI34054">
        <property type="protein sequence ID" value="EFI34054"/>
        <property type="gene ID" value="Dthio_PD1393"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="554" mass="63196" checksum="D5EDA6EC00A97B17" modified="2010-08-10" version="1">MDIRSIAHLGRFREIITTLAKYGFHDIVERLEIPGLKYLKKVKPKHEDLHTWERVRKILEELGPTFIKLGQILSQRADIVPEGLMKELSKLQDDVHAEDFEDIKKVLEKNYAAPLDDIFSEIDPLPLAAASMAQVHRARLRENGREVALKVQRPGIEETIKNDLEILEKIAVQLDGRMEYFKVYNLPQLVRRIKKLIFSELNFTYELRNMQVAAAQMKNEQRLRVPDTFPELSTSQVLVMELCKGTQMKNVDIAGLTGREELAKSALHFTLRQVLGQGFFHADPHPGNILVDDEENLIILDWGMVGRLTPKVRHDLIDLIAAIVENDVDEVTELLLNFTSGTENINMDALQGEVLEIVSHFTRMPLKEINLGRLLMELTTALREHGRVLTSDLSIMIKSLITAEQTAKMLYPDLDVVGEAEPILRSIGKERFKPDNLLKGLYKNFRYLLRFQYQLPRQAMDIISKLDQGQLAIRFRHENLEGMQTTMETVVNRLVAGIIAAALFLGASMIFVADTGPMLWGHPLLGTLGYAVATVLCLNLVVTMLRSRRRRFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STT1</accession>
    <name>D6STT1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871446.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1437"/>
    <dbReference type="EnsemblBacteria" id="EFI34097">
        <property type="protein sequence ID" value="EFI34097"/>
        <property type="gene ID" value="Dthio_PD1437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="12016" checksum="B3B7E9C1CBE6E79D" modified="2010-08-10" version="1">MALLITTQPYAQQEIIRGITRVICEHSPNSRRKFQEKLHNLAALPSTDVVITGYTEGFSHPEFTLAWYRQNGNPDLHPLERQEGPFMVGVMVFHDFEDCWCTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU60</accession>
    <name>D6SU60_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871536.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0147"/>
    <dbReference type="EnsemblBacteria" id="EFI32840">
        <property type="protein sequence ID" value="EFI32840"/>
        <property type="gene ID" value="Dthio_PD0147"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014555">
        <property type="entry name" value="RecF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029347">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="252"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="368" mass="42353" checksum="9F7BC5E730F4B4EA" modified="2010-08-10" version="1">MLKKIYVNNYRCLVNFELDLGKMTILMGPNGGGKSTLFDLLRNIRRLLVDNARVNNVFPAEELNAWAGGTKQTFELHVGNDKDLYVYRLIISHNPDINKQRIDLETLTINDQALFEFKQGEVQLYTDHFEAGPGYPFDWSISALATIVPRGNNKKLTWFREWVEKLFIISLQPRHMDSVTVEESSWLNHDGSNFASWYRYISQEHQDKAFALTEELRLIVPGFHSFKLEAAGKQRVLKIGFTADSAHSSPLYFDFRQLSDGQRVIIVLYSILHGLRNLGNSIFLDEPENFVSLAEIQPWLIELRDACEEAFPQAVLISHHPELIDYLAPEYGRWLQREPLGPTRVKPMPKNLDPSIKLSEHIARGWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU66</accession>
    <name>D6SU66_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MmgE/PrpD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871542.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0153"/>
    <dbReference type="EnsemblBacteria" id="EFI32846">
        <property type="protein sequence ID" value="EFI32846"/>
        <property type="gene ID" value="Dthio_PD0153"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="688128at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="267"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="448" mass="47408" checksum="0DE93FDD8056CB02" modified="2010-08-10" version="1">MNTTDLFIDSLFAISKAPPSDAVSLQAKKCLLDYLGVTLAGARMLEQKSKELLNLLNNSQSECTVLGLNRKSGVQSAVLINGINSHVAELDDGQRFGMLHPGAVVISTLLPLAQREKISGATLLQGIVTGYQAAVKVATAVQPAHKMAGFHATGTCGALGAAIGVAAMLGFPQNQMKDTLSAAATSASGILKMTRDSSELKPYNAGQAALNGLVAALTARAGFKGPDDVLAGEKGFLEIMAPGTKGDRPELGAGEALEIEDVYFKPYAACRHCHPAIEAVLALRSKHKLALENIKAVKVFTYHLGVEGHDHTRIPNVASAKMSTPFSVAAALATGSAGLDAFTPETVVNADIVSVTRKITIISDDQLSALVPHKRPAIVEVTTHNDKVLREKVFLAKGEPENPMTQDELEQKFASLASFSGMKVSDIDSIIHCVWDIENCLDELFTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUE3</accession>
    <name>D6SUE3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma-factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871616.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0237"/>
    <dbReference type="EnsemblBacteria" id="EFI32923">
        <property type="protein sequence ID" value="EFI32923"/>
        <property type="gene ID" value="Dthio_PD0237"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="99" mass="11044" checksum="7B90DAA9479907EA" modified="2010-08-10" version="1">MQGEENQLVLKIDQNIVSANAKEIKEKLKESIPQESGTLVVDLGQVDQVDSIGVGVLIATFNSLKKEGKGFKLVNVDDNLYNLFQVMRLNKHFEIEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUK8</accession>
    <name>D6SUK8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="13" type="ORF">Dthio_PD0302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871681.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0302"/>
    <dbReference type="EnsemblBacteria" id="EFI32988">
        <property type="protein sequence ID" value="EFI32988"/>
        <property type="gene ID" value="Dthio_PD0302"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="662686at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="34"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="259"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI32988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="347" mass="39353" checksum="971BBBD903041D9A" modified="2010-08-10" version="1">MIIQTNDKLINTRNWSSLVKPDQVQRDEKSTEQYGKFSCEPLERGFGNTFGNALRRILLSSLQGAAIVAIKIDNAPHEFATITGVVEDVTDIVLNLKQVRFKMSRDEPQKLKLVANEKGQVTAKAIQTNQNIAVLNPDQHIATLSQDIDLVINIEVRMGKGYVPSEQHEDLDEEIGLIPMDATFSPIRKVSYTVEQARVGQMTNYDKLILEIHTDGSVLPEDALAYSAKILKDQLSVFINFDESQTDINVIDTNSDEGLDPKLFKTIEELELPVRAGNCLRNAGIRLVGELIQQSENDLLRTKNFGRKSLEDIRRVIEQMGYDFNTQIDNFDQKYQEWLKRKEDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUL0</accession>
    <name>D6SUL0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="9" type="ORF">Dthio_PD0304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871683.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0304"/>
    <dbReference type="EnsemblBacteria" id="EFI32990">
        <property type="protein sequence ID" value="EFI32990"/>
        <property type="gene ID" value="Dthio_PD0304"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="129" mass="13987" checksum="FCF9466D7BED3104" modified="2010-08-10" version="1">MAKPRKTKKRKEKKNIPTGIVHINASFNNTTVTITDQTGNVVSWSSSGMVGFKGSRKGTPFASQKAAETAARLAHENGMRTVGILVKGPGAGRESAMRAINTSGFKVTYIRDITPIPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUN2</accession>
    <name>D6SUN2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ORF">Dthio_PD0326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871705.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0326"/>
    <dbReference type="EnsemblBacteria" id="EFI33012">
        <property type="protein sequence ID" value="EFI33012"/>
        <property type="gene ID" value="Dthio_PD0326"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="206" mass="22914" checksum="71F55F6A5A1DCF27" modified="2010-08-10" version="1">MLSAKVYSQDNQEVGEIDLQENVFSVSVKPELMHQAVRAHRAAVRSGTVGVKNRALISGGGRKPWRQKGTGRARAGTGRSPLWRGGAVIHGPKARDYSIKLNKKVRRLALKMALSTKYAQDKLQILDNLDLSRIRTKDFVSIKNNLGLKKPLIVTAEKSNNLELSARNVPGVEVITQDSINVYEVLKHQELVMDKQAVEKLQERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUP8</accession>
    <name>D6SUP8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ORF">Dthio_PD0342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871721.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0342"/>
    <dbReference type="EnsemblBacteria" id="EFI33028">
        <property type="protein sequence ID" value="EFI33028"/>
        <property type="gene ID" value="Dthio_PD0342"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="397" mass="43585" checksum="633346BC58AAFA77" modified="2010-08-10" version="1">MGKSKFDRKKPHVNIGTIGHIDHGKTTLTAAITKVLSLKGSGQFVAFDKIDKAPEEKERGITIATAHVEYETPNRHYAHVDCPGHADYIKNMITGAAQMDGAVLVVAATDGPMPQTREHILLARQVGVPSLVVYLNKVDLVDDPELLELVELEVRELLSKYDFPGDDVPVVRGSALKALETDDPDSEDAKSIWEIVQACDDFIPEPKRDIDKPFLMPIEDVFSISGRGTVVTGRVERGIIKVGDEVEIVGMTDTRKTVCTGVEMFRKVLDQGQAGDNVGVLLRGIKRDDVERGQVLAAPKSIKPHRRFKAEVYILNKEEGGRHTPFFSGYRPQFYFRTTDVTGVVTLPDGVEMVMPGDNTTFDVDLIVPIAMDPGLRFAIREGGRTVGAGVVSEIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUV2</accession>
    <name>D6SUV2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871775.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33082">
        <property type="protein sequence ID" value="EFI33082"/>
        <property type="gene ID" value="Dthio_PD0397"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="308" mass="35885" checksum="CDE95D34718C1BB8" modified="2010-08-10" version="1">MPRIARFIRDKQPTIYHIVSRTALQGLPIKDKDNDFLLGLIKKLSAFYFVDVLGFALLGNHFHLVIRIYPESDPTDDEIRERLQKYYGDGLKVTGLLISDYRKRLTDLGAYVKDIKQGFTRYFNKKYGRRGFFWGDRFKSMIVQDGLSLVNLLAYVDLNPIRAGIVKKPEDYRWCSLGYHTQTGNKDGLLSIDFGMKEWNEFDPSEIVRKYRQFVYETGAVDAGKGKVMDKKIVEKARKKGYKVSRAERFRYRCRYFTDSGIIGGKDFVQEVFDQVKHLLKSKDERKFTPVKGVDGVFSMKRLMEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUZ5</accession>
    <name>D6SUZ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871845.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0040"/>
    <dbReference type="EnsemblBacteria" id="EFI32751">
        <property type="protein sequence ID" value="EFI32751"/>
        <property type="gene ID" value="Dthio_PD0040"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="7"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="341" mass="39994" checksum="41B32A59FECD4CD1" modified="2010-08-10" version="1">MSFEIPNPHNACFKDFFKDPEFVKAFIKYHIPEEICSLLDLDTLQVDLSGFVSEEHREYYADVMVTVQLKGHTENVNIYILLEHKSTPEFLTRLQILNYEVQKWMDLKRKGQLQGYLPVIIPVVIYHGKGRWNFSRKFSDLFDLPSEVLRPFVPEFKHMIHDISSMEDDEFKTTAILEIFHLLFKYIHYPELETKLQEIYDLLETIPDQDKVKQYLQAIVQYVAVQGPISLERLGEYTRRLPGGDEAMQTAAQQIRQEAYNEFIQEQEKMLVEREKHAKLEATQENLIDAATEQYGPLPGTLHEKIKSIQSLENLRALNRKVLRTQSLEEFTELVNRAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUZ6</accession>
    <name>D6SUZ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871846.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0041"/>
    <dbReference type="EnsemblBacteria" id="EFI32752">
        <property type="protein sequence ID" value="EFI32752"/>
        <property type="gene ID" value="Dthio_PD0041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="196" mass="22253" checksum="C4B2C8C73446EE18" modified="2010-08-10" version="1">MANTNHPKKGSSITVEPIRSQEDIKSIKKLLSGNPRDYLLFTMGINNGLRIGDLLQLKVRDVQGVKPGDTIRVKEQKTGKPNVLVINKATHKALQTYLSQTLAEPEDFLFKSQKGNTPLTVSYANRLIKLWCKTINLRGNYGTHTLRKTFGYIQRVHYGVGYELLCKRFNHSSPAVTMRYLGIEDKEVNNILMHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV46</accession>
    <name>D6SV46_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871884.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0100"/>
    <dbReference type="EnsemblBacteria" id="EFI32802">
        <property type="protein sequence ID" value="EFI32802"/>
        <property type="gene ID" value="Dthio_PD0100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1735"/>
            <end position="1764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1764" mass="193926" checksum="1315099F3C5E4C6D" modified="2010-08-10" version="1">MSSDGTNYPGGTRDEARFIELTQEKSFAFHLSPQEYHYYQFDADQSAMEIHVTKGDVSVELQDEDGNTLANGDQGIRYGGLEEGRSYYIQVENEAGSWWWQDKTEYHLDITPLDFLPADDPDEAVDLVPEEDREAALQPGDGSHYYQFELDEARAVDIEATGSVSLTLKDSQGEKLQEGEDFLQKDSLDAGEYKVVVEHQDSRWWWQDKTEYSLGLNTAEAGRPDEPGRDPDAARVIDIWEAVSEEGKSFQEEVPAGEDHFYKFELDVDAEVGLEATGNVSLDLLREGDEGDSLQTVKADKNSIQTELDPGEYYVQVSNETGEWWWQEDAEYELDFEVSKIAELEPDLTTRVSGFDTTNESGYDEYFEPPIHKNPTSVTIAEDSHTAGSTLVGVEGIYLVGFGDADEHWDLTDLAEFSGIDTMDLQNASKLTLSGDQYKEISEALNGEESEVTVEGADKDVEIWQGDVDTLILDDQVQERSIEVGSVIHNKMELTSSDLDSLELSMHGAAISKVATNNELQDLRINSTYDDPEYGGGNTLFDPDRIDLADAANVSIEGSRDVHLGSIRGNLTLADQTTVDAAELDSRLFLYVEAASGADNLVTTGSQTGDNHIRAYLDKAASGASYSFTGGTGEDYIRIYEAGNSQSRAELDISSAGGDDNSIYLYDVYAQGSISGFQSINAAKGDVDLTRMDIQGLEVIRIGSADLFTFIDSTMHLTASQVQDFGDDVEYSRSHEGGKLSLLVQQDADLSNAHSSLAQVLNQVDFQGNDVSLQISSDQADSLAVKGTTKDSELVIHAKDIGQHQSRDMTLNLDMNGADLSFEFGTLLNQTLNLTQESSLQNIATLRVNSDTYSGILSVHPDTILDVDSFMVKEDGVLELSADQANGEDISGQGTLQVNNYNGTQDFSQVGTRQVRVNSDTGFTGAELELLETERIHFRFRDEAGFDSISAGNAEFIQFSFAVGTNEVTVLDAEKLEFLHINLSRRNEVLFKGFGDEDTDLSSLEEVTVWWGSENASVELDFVASSDGGANNLDTFDFQLLHEDTQVFLRFTEQDMDFNDIVVKLSSYGQEITLNDKAANSFSGKLSLKGYEGQEYNVQLGKGGVNQLGLSEEGRFTIAYEEGDIVISGFKTDEGSDRLDFTALAKSWAWDSVDNILTSSDGEWELDFGDDGDTDAQVDIVNKDGEGFGKVVLDGVDPDHLEMGNFESFSTVTEDELRDAVADGSYAVEHNGVEYTFEDSEYNIDTSQVMDMSGLFYGSDFNKDIGYWDVSSVANMFGMFESAEFNQDIGDWDVSSVEDMGWMLYNAKLFEQDLSAWQVPGIAEKPRDFATGSPLEGRDEWHPNWGGIEKLTVTIDSLSTAGEAGSSVHVNVTVEHTGNAGQVEFTVTQDTTGVTERVDLNHSVPAEEEVSWTLEDTLAFDPGAVELEVSVEEDGETVSEVKTFGLYEDEEDRDFEWQWSDPDKSPFDMIGHVVADHDGYDEGWYGTGTGFLISPMHIMTNAHVITDDEDWASDLSELNAVDFFLGRNGGNLFDEQDGNEYAGEHAYLQKDEWGKAWPDTDMAIVTLDREVEGVEHFDWFWNAGQETDRDVTGDSVTISGYPSENIEQGEDDRGNNIYFQWNAQGTATDYLPGYDEYGQESGGLEFSQDMSFAGGASGSPVIRETVNGDYQFVGAYTGSIGADPVAATLDSTAFDWALTVVQGDGYLTDQEYVYGGLDPEDMGPDKLLPGTDTAVARSSEGGESVGIKVQGVPQDELDDYSGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV61</accession>
    <name>D6SV61_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0119"/>
    <dbReference type="EnsemblBacteria" id="EFI32817">
        <property type="protein sequence ID" value="EFI32817"/>
        <property type="gene ID" value="Dthio_PD0119"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10141" checksum="8BFFC7EDD885986A" modified="2010-08-10" version="1">MDFTWDDTKDRSNFKKHGVSFVEATEVFGDVFSSCVSDPDHSVEEDRYLLFGTTSKGRSLVVSFTECTGTIRIISARQMTRKERTAYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJQ4</accession>
    <name>D6SJQ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869232.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3559"/>
    <dbReference type="EnsemblBacteria" id="EFI36107">
        <property type="protein sequence ID" value="EFI36107"/>
        <property type="gene ID" value="Dthio_PD3559"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1824570at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025455">
        <property type="entry name" value="DUF4276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14103">
        <property type="entry name" value="DUF4276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="25741" checksum="EAEE013DC70C46C3" modified="2010-08-10" version="1">MIRVHVICEGQTEERFVNELLVHSLASINVLAQPALIGKPGHKGGNLRFERLYKDIRNKLLGDKAAYCTTFFDYYGLPGDFPGKSEAGKYNDHEQKFNCVIMSISEHLEEKLGPEPMRRFIPYVQMHEFEGLLFSDPAAMARGMYHQKLTQHFLKIRDQFNSPEEINDRYEFAPSKRIQKLCSEYEKPLHGLLAALEIGLDIIRKECPLFHDWLSRIEKITAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJS2</accession>
    <name>D6SJS2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869250.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3578"/>
    <dbReference type="EnsemblBacteria" id="EFI36125">
        <property type="protein sequence ID" value="EFI36125"/>
        <property type="gene ID" value="Dthio_PD3578"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="156"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="400"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="533" mass="59027" checksum="BFB648D38F88C2EA" modified="2010-08-10" version="1">MSELRVLIVEDSHDDVLLILRNLKKAGWQVAHENVQTQEHMRQALQSRPWDLIISDHAMPEMDSFKALNVLYESGLDLPFILVSGSIGEETAVEAMKAGVNDYIMKDKLARLAPAVRRELKEAENRRAKKEAHEALVAAKEAAEVASRAKSEFLANMSHEIRTPLNGIVGMLQLLSSTGLDTEQEEYIRLGQSAAQRLTRLLSDILDLSSIEAGRMYIRENPFSISHVCESIHDLFIITAREKGIHFDISLDPQIPKKVMGDATRVSQILFNLVGNAFKFTDQGSISLDIRLAEQEQDRLLLHISVADTGTGIPPDKINELFQPFTQADGSYTRKYQGAGLGLVVVQRLLDLLEGRIEVDSIVGQGTTMHVSMPLKTLPEEDAGLPLQKEQEPGPGKALNILVAEDDPMNQIFIKNLLTKEGHNVSMAKNGREAVELVQEHSFDCVLMDIQMPVMTGVEATREIRNLGGNGSIRNVQIPIIAVTAHTQPGDREKFLDAGMDDYLGKPVSLEDFRNVFRKFFGPGVVQGLKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK59</accession>
    <name>D6SK59_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869381.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3725"/>
    <dbReference type="EnsemblBacteria" id="EFI36262">
        <property type="protein sequence ID" value="EFI36262"/>
        <property type="gene ID" value="Dthio_PD3725"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1962851at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="313" mass="34838" checksum="DE7B92AF5E838A65" modified="2010-08-10" version="1">MKHGDNRRKKRIRSRLSFSGWMYVLLCLLVGMAAVNSNNNVLFLITSLLLSLLFLSGLIALYNVSGLRVQAVGRDILTSNEPGTIMLRIQNTKRFPALVLQAGLEDQRALLPVIGPGRHKDIFISWTPPFRGQPPLPPVRLASSFPFGFVLRGGLFDPGKGPVVAPGPLGASARSLMAREQPRSHTFRTQGSAEWQGIRRYRPGESRAAIVWRRLDWSMPAMGMDISRWPAHSFSSEHAASLVMDWEDPAYAHLDTEKRLALFRSILDRALQEYSPWELRLPGRQISGHPGADPFYALQALALMEPLPGQEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK60</accession>
    <name>D6SK60_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869382.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3726"/>
    <dbReference type="EnsemblBacteria" id="EFI36263">
        <property type="protein sequence ID" value="EFI36263"/>
        <property type="gene ID" value="Dthio_PD3726"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="670657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="418"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="694" mass="78057" checksum="7D30DE12FD6FC738" modified="2010-08-10" version="1">MSSEHTGFRLRLLSPLLGISAGSYVVLSLNTILAPWVALFWTVSCVLAFAAYYRGRKEVFSYRFRLITVLLLVCLAVAAHWPQGWQYVLAQALVVMLGIKLMELRTQRDAFQFCGLGVLGLAAASLVRFDLGFGGLILLFFFLGLVLILWQHVLDHTPDRAYRDSPGWGFASGLVVFALFLTVLTIILGLVVFFAFPRNISPALNLGEGMQTHLTGFSQEMSPGSVSEIVASNRIAFRAVIEDPVDPSRLYWRGAVLWETDGEKWTRGTPHDFQTNPVTASSLDHGLIRQSITLNPGTTEHLFGLYFPQRVLDVSPVNYNRDGTIKKDEPVETAIRYRVLSRAGDSGPLTTRESKSALAVPEDLDQEVVSLGKMFQDRDQDVWETAQEIMFYFGTQGFEYSLSAPEEFEQGQSLKDFLLRTRTGYCELYASAAAVLMRINDIPARVVVGFWGGEFNPVGEYWVVRDSMAHAWVEAWFQGRGWVLLDPTRMLEHTGMEEPGDDAAAAREEDGPQQVMSPGPATLDWLRWQWTNAIIDLTLARQVRMWRSVSSGIQDTWSGLSLPDLPRSWSRPDNGKLLLAAAAAIAGLALLLLRIYYPAGDQAKRLRQKAWKRLARKTPGRHHLQRPGSEQQVWRWWEENRPDMAAELKSLYHAQRYGPSPDLEKDRRLKTLLAGRLPCAYKQKKGYGTKSITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK83</accession>
    <name>D6SK83_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869405.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3749"/>
    <dbReference type="EnsemblBacteria" id="EFI36286">
        <property type="protein sequence ID" value="EFI36286"/>
        <property type="gene ID" value="Dthio_PD3749"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1896719at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14481" checksum="EF5B37A10DE58B87" modified="2010-08-10" version="1">MELKEYFENTKGTGVLSTADSQGNVDCAIYARPHVMQDGNIALIMRHRLSRQNLQSNPRAAYMFIEQGPGYKGKRFFLTKTGEEQDQEKIQSMSRRSSHADQDLNPEPRSLVYFRIEKELPLVGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK85</accession>
    <name>D6SK85_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="3">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlmH</name>
        <name evidence="4" type="ORF">Dthio_PD3751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869407.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3751"/>
    <dbReference type="EnsemblBacteria" id="EFI36288">
        <property type="protein sequence ID" value="EFI36288"/>
        <property type="gene ID" value="Dthio_PD3751"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1783583at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="154" mass="17476" checksum="0F03B48F62D42F44" modified="2010-08-10" version="1">MRGIKIVLVGRFQKGFFREAFDFYLQRVRKVTQAEVVEVKEVRHRDPDLRMQKEGENILARLGPRDLLLVMDEKGTALGSGSMARELSRWEEDPGCVPCFVVGGAYGLSENVRSRADRLIGLGPMTLPHELAAVVLMEQIYRAQCISRGHPYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKD9</accession>
    <name>D6SKD9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869461.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3810"/>
    <dbReference type="EnsemblBacteria" id="EFI36342">
        <property type="protein sequence ID" value="EFI36342"/>
        <property type="gene ID" value="Dthio_PD3810"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2098838at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11653" checksum="8A3AAA8EA650F394" modified="2010-08-10" version="1">MSYTEIIHVHAYNDKCRKKALDKAREISPGASDRLESVSIFLRRDWETEIVILLTWEERPGGQTYSTEGLSIVECLSRFGWVAHSAWTLDQARKRQTIGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKF0</accession>
    <name>D6SKF0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gatB</name>
        <name evidence="12" type="ORF">Dthio_PD3821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869472.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3821"/>
    <dbReference type="EnsemblBacteria" id="EFI36353">
        <property type="protein sequence ID" value="EFI36353"/>
        <property type="gene ID" value="Dthio_PD3821"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="328"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI36353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="476" mass="54002" checksum="C4963E9E6A3C021D" modified="2010-08-10" version="1">MSDYETVIGLEVHAQLKTRSKIFCSCSTQFGNDPNTNTCPICTGMPGVLPVLNKRAVEFAVKMALALDCRVNERSVFARKNYFYPDLPKGYQISQYDQPLAEHGHIKILAQNREKDVGITRIHMEEDAGKSIHSHSEGLSYVDLNRTGVPLMEIVSEPDMRSPEEAAAYLKALRSILRYLDISDGNMEEGSFRCDANVSIRPRGKNELGTRTEIKNLNSFRNVQKALEYEVSRQMDILEDKEEVIQETRLFDPDRGITVSMRGKEEAHDYRYFPDPDLVPLLVDRDWTLRLKKELPELPMARLARFISQYELPHEDSQVLTSERDLADFFEECTRLYAQPKKISNWVMTELLRELNQAATSIKESGFSPGLLAKLVRMVDEGTISNKIAKSLFPEVFASGSDPEKLVQDKGLGQISDSGELERVVDEVISENPDEVQKYQQGRKKLMSFFVGQVMKKTKGQANPGLVNELINRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKH7</accession>
    <name>D6SKH7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator, NifA subfamily, Fis Family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869496.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3852"/>
    <dbReference type="EnsemblBacteria" id="EFI36380">
        <property type="protein sequence ID" value="EFI36380"/>
        <property type="gene ID" value="Dthio_PD3852"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="196"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="521" mass="58286" checksum="93D26E2841C434C6" modified="2010-08-10" version="1">MASKKLSRGVSTEVIIRELVRRVSSPVSRSSFFQSLSRLIQQQFSFDRLCINLYDPNSELISFFTAAEGTVVNALSPTRKAEKSTVAGHVISTKKPVIITDLAQYFSEELQNPLTESGLTTTMAFPLIINDDIIGTIHCSFVQEPDNLYAIMEFFLDIAPYIAICIGALIASEQKERWVATNIASHSDPKISQEGFIYESAKIRQVMKTADRVARLEIPVLILGETGTGKSLLANIIHSISKRHNNTFVHVNCPAIAESLFESELFGHAKGAFTGALSSRVGRLELAQKGTLFLDEIAELSLEMQSKILHVLDYQSFQRVGESSSIPVQTRIIAATNINVDKAIRQDKLRKDLYYRLSTYIIEIPPLRERPEDIPVLSNYFINELSTSQGLPKINLSDELMHALINYYWPGNIRELKNVLNQLLVKNFIANKIDCNDIKEVMSMDTMNSRIPEKNNCTDDSDNSGNIDDVSMSLQEVEKRHIKEVLHFTKGVISGPKGAATLLGLPRSTLQHRMRKLGITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKK3</accession>
    <name>D6SKK3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868348.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2623"/>
    <dbReference type="EnsemblBacteria" id="EFI35214">
        <property type="protein sequence ID" value="EFI35214"/>
        <property type="gene ID" value="Dthio_PD2623"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="254" mass="26928" checksum="5A20D912E4CDD6C3" modified="2010-08-10" version="1">MEYALWLYPLIFVSSFVLSMAGLGGGLIFAPLFLLVGFAQSSAVASSLLLNALAATTASYVYIRKRMVDFSLSIPLVISSGLAAPIGAMCTRWVDEGVFLCVMSVVLFLAAVRMMFVGGVAGQGTRAHVWSLARVLQASFLGLVIGFMAGMLGIGGGVFVVPLLIYMLQVNPRTAAATTAFIVCFSSYAGFATHVAVTPLDWKFLVLAGIFSSAGGLAGSRLMSSRLSGAFVRKLFALVLFFLSLHLMYQGVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKL9</accession>
    <name>D6SKL9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868364.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2639"/>
    <dbReference type="EnsemblBacteria" id="EFI35230">
        <property type="protein sequence ID" value="EFI35230"/>
        <property type="gene ID" value="Dthio_PD2639"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="340" mass="37132" checksum="25018416BE4F0BF7" modified="2010-08-10" version="1">MSKKVRVGINGFGRIGRQVLKAIWKYHRDTIEVVAVNDLFDINTNAHLLSRDTSYGPFEPSISVQGDAIHVGDDFVVHNSAERDPRLIPWGSLGVDVVLECTGIFRTKEKASMHLEAGAKKVIISAPAKEEDITIVLGVNESDYDPDRHHIISNASCTTNCLAPVVKVVHEHFGISKGVMTTVHAYTNDQRILDLPHSDLRRARAAACNMIPTSTGAAKAVALVMPEMEGKFSGFSVRVPVPTVSLVDFVCELERDASTEDLRSVLKSAAQGPLQGILGYSEDPLVSSDFIGDPRSSIVEADFTMVQSGNIAKIYAWYDNEWGYSCRIGDLVAYMADKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKN3</accession>
    <name>D6SKN3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868377.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2655"/>
    <dbReference type="EnsemblBacteria" id="EFI35244">
        <property type="protein sequence ID" value="EFI35244"/>
        <property type="gene ID" value="Dthio_PD2655"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1999402at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="12386" checksum="D9A69CE05B5748FF" modified="2010-08-10" version="1">MSNYIQTRRQGNLIRANLIHWSQFVQRTGVCPSMLGELVEMGWVESICTSPESYHFPEKEVFRVQKLVRLCRDFELPTIGGVLIIDLLDRIEQQDKEIRQLRRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKU3</accession>
    <name>D6SKU3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase 28 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2719"/>
    <dbReference type="EnsemblBacteria" id="EFI35304">
        <property type="protein sequence ID" value="EFI35304"/>
        <property type="gene ID" value="Dthio_PD2719"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1984122at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="PTHR12867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="171" mass="19607" checksum="AFB4542B73D750BF" modified="2010-08-10" version="1">MILLTLGTYPLSFERLVRIVDQGIVSGQIKEDIFAQIGFSSYIPKAMKYELIMEKQHFENVLRSSTAIISHAGMGTISLALSENKALLVFPRLVMYKEMVNDHQLSTARKFEETGHVLAAYTSEELYEKIRLLKNFTPKPRYSSPERVSRCVGRFMQNINLNCALKKEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKW5</accession>
    <name>D6SKW5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2741"/>
    <dbReference type="EnsemblBacteria" id="EFI35326">
        <property type="protein sequence ID" value="EFI35326"/>
        <property type="gene ID" value="Dthio_PD2741"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018759">
        <property type="entry name" value="BBP2_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10082">
        <property type="entry name" value="BBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="393" mass="45606" checksum="D157251F04621FF8" modified="2010-08-10" version="1">MDFQKCRVFLPAMVLSAVIILSVHIEKSGAAEWIITPEMSVTGTYDDNLLFEDVSDYELRASPGLRANMTGERTRLEVAGKVDVLSYLDYSEFDRVNQDYTLQSEYDLNPRTTLKMGGRLRFDYTFETELEEAGIVSEKSRRSYYTFLPGISVALDERNSLALDLFYASTDNRRDERADSWSTGGDLVWSRMFLDEQTFFLAGAGVEHVDFESRRVEGTHDIYRGIVGVSRDMGERYNVLLRGGPTWTHSRFDRNDERRRDDDLGFFIDSRLLWQITERTSTDVGIDHGQYQSIYAENITRNRIRAGLRHRFTEKWSGNATGSFINSRTTGLVSREKRNTWQTGLSATYNLRPDMFFDLGYRYRHTRDRVDSTSKDGNRFFLQFTIRFPKQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKY5</accession>
    <name>D6SKY5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine synthetase, type I</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868478.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2761"/>
    <dbReference type="EnsemblBacteria" id="EFI35346">
        <property type="protein sequence ID" value="EFI35346"/>
        <property type="gene ID" value="Dthio_PD2761"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="111"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="448" mass="51263" checksum="824F066F3BF72052" modified="2010-08-10" version="1">MQKPVVFDCRNADDVTRAVKEHDISFVQFWFVDVLGNLKSFQVTPSELDEAFEEGMGFDGSSIEGFSRIHESDMLAYPDPTTFQIVSWRPMERPVARMFCDIKNPDGSPYEGDSRYVLKRILGKAAEDGYSFYVGPELEFFLFESSREPKTLDFGGYFDAPPLDLANDIRRDIINALINMGIVVEYSHHEVAPSQHEIDLRYQEALKMADTAVTYRVIAKEVARRHGCYATFMPKPLFGENGSGMHVHQSLFKNGRNVFYDPDAPDNLSKECRNYISGLLEHANEITAVCNQWVNSYKRLVPGYEAPVYVAWARRNRSSLVRVPMYKPGKEKATRVELRSPDPACNPYLAFACMLASGLKGMEKKYPLPEAVEEDIFEMNEEERKKHNIPSLPGSLFEAVEVLEKSAVVRQALGEHIFNNFIANKKIEWNNYRIQVTEYELKKYLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKZ1</accession>
    <name>D6SKZ1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trpD</name>
        <name evidence="9" type="ORF">Dthio_PD2767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868484.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2767"/>
    <dbReference type="EnsemblBacteria" id="EFI35352">
        <property type="protein sequence ID" value="EFI35352"/>
        <property type="gene ID" value="Dthio_PD2767"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2 6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="7">
        <location>
            <begin position="75"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="6">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="6">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="6">
        <location>
            <begin position="109"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="34843" checksum="E0A7B7F05336E27C" modified="2010-08-10" version="1">MQIKQVLNKICSGQDLDYSEGRDVFQALFEGEISPAQSGALLMGLRTKGESASELAAAVSVALQRARLVHGLTGKTIDTCGTGGDSRQSFNCSTAVAFFLADQGIQVVKHGNRAVSSSCGSADVVEALGLQLLDNPDLVAGELAARNFAFLFAPHFHPSFASIAPLRQELGIRSLFNLMGPLLNPARPTHQILGVPHAGFMPLMSGVLAESGVQSAAVVHGAMGFDELTPCGVNQVIMVREGRQEDMLLDPEPLGFEACSPEDLACADKESALARQREILAGEGPGPMQDMVALNLGLGLHLLNPDVGLEECMHEAASIVRGGLKTLNFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL19</accession>
    <name>D6SL19_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Substrate-binding region of ABC-type glycine betaine transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868512.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2796"/>
    <dbReference type="EnsemblBacteria" id="EFI35380">
        <property type="protein sequence ID" value="EFI35380"/>
        <property type="gene ID" value="Dthio_PD2796"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1379790at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088225" evidence="2">
        <location>
            <begin position="24"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="182"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="311" mass="34922" checksum="6E8EF2AB565D7AE9" modified="2010-08-10" version="1">MKMLNKIMLLAVLAILILPGCGSDDTGKGEAKLKLASSAEWTQRSDGLPNFQEHYGFEFPELAVVDLGLAYQAVGEGLAHVGIGDATEGRIVKYDLVVLEDDKAFFPAYNPAPLVRKDILETYPELEKIMQELSSRLDLKTLSMLNKKVSIDNEMPRDAARYFLLQEGLIKKEPPEQKDAGEIVVGGKTFTEALTLGYLTRYLLEDRGYKVVDETGLGETAVITPALFSGQIDIYWEYTGTGLMNVMGYDEVVTDPQECYELVKDWYLENHDVVWLDYAPANNTFVLFTSRELHEEHGWEKISDLGEYVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL35</accession>
    <name>D6SL35_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868528.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2812"/>
    <dbReference type="EnsemblBacteria" id="EFI35396">
        <property type="protein sequence ID" value="EFI35396"/>
        <property type="gene ID" value="Dthio_PD2812"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="148"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="222"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="299" mass="34044" checksum="413A4986119DEA09" modified="2010-08-10" version="1">MKKDFLSIRDLTREEAHELVERAHWMKAEDFRSNLLEGKTVILIFEKASTRTKVSFEVSINHLGGHHVFMTPAESQLGRSEPLRDTARVLSRYAQGMVVRTFGQDKLVELARHGSVPVINALSDDFHPCQVMSDLLTIFERTPEFEALNIAWVGDGNNMSHSWINAAVHFPFRLNIAVPRGFEPRADILQEAKDLGANINFTHDPLEAVREAHYINTDVWASMGQEEEKKSRADAFAGFRVDDRILEAAHPEARVLHCLPAHRGEEITDAVMEGERSIVWDQAENRLHMQKAILEWIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL52</accession>
    <name>D6SL52_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2831"/>
    <dbReference type="EnsemblBacteria" id="EFI35413">
        <property type="protein sequence ID" value="EFI35413"/>
        <property type="gene ID" value="Dthio_PD2831"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="265" mass="28491" checksum="6CF5D98293F2D389" modified="2010-08-10" version="1">MGTVPHLFFEEPFSAVGVGKISAGQSPGLVPVITTEDPVNGYVLSVHHEGKQNKIIILALLAVLLAGNLFFIFKGLPFDLEWLQANQKTIEALSSEYFLASILLFVLLRFVFAVVSIPGTGVLTIAGGAVFGVWLGSLLAALAVGCGVTVVFLMSRYALKDYVRSRFESYTGYIEKGMQEYGTGFLFMLRIIEVAPSFVINSVFAFTDMRVKTFFLVSLAGFLPGIFIFANAGSRLAQIDAMSCLMSTGVMLSLAVTIQGVLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL88</accession>
    <name>D6SL88_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868581.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2869"/>
    <dbReference type="EnsemblBacteria" id="EFI35449">
        <property type="protein sequence ID" value="EFI35449"/>
        <property type="gene ID" value="Dthio_PD2869"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="164" mass="18650" checksum="CE98D03302393C69" modified="2010-08-10" version="1">MSKTQKNLQDAFAGESQANRKYLAFAKQAEKEGFPQVARLFRAAAEAETVHAHTHLKNMGEIKTTKENLETAIAGETHEFKHMYPQMIKEAEEEGHNAVKRSFQFANDVEEVHANLYKKALEKMENLEEAEYYICSVCGYTVENDAPDKCPICNAVKKAFYKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLA8</accession>
    <name>D6SLA8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35469">
        <property type="protein sequence ID" value="EFI35469"/>
        <property type="gene ID" value="Dthio_PD2889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="44" mass="5019" checksum="8589FA19D94AC5E8" modified="2010-08-10" version="1">MSDSFCVKSVFKKLKVLVAEMGLTIKALLLMCVERLREGKEMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLP1</accession>
    <name>D6SLP1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UvrABC system protein C</fullName>
            <shortName evidence="7">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">uvrC</name>
        <name evidence="12" type="ORF">Dthio_PD3031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868731.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3031"/>
    <dbReference type="EnsemblBacteria" id="EFI35602">
        <property type="protein sequence ID" value="EFI35602"/>
        <property type="gene ID" value="Dthio_PD3031"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 7" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="9">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="11">
        <location>
            <begin position="252"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="605" mass="68682" checksum="CB94DD9AC5D60665" modified="2010-08-10" version="1">MQYQFNSSDFPRDPGVYLMKDEQNRIIYVGKAKNLRSRVSSYFRSSRDPSPKTRVMLGRVLQVDYITTTSEKEALLLEASLIKKHRPRYNIVLRDDKQYVLFRLDKSRPYPALELTRSARRDGSVYFGPFTSAAAARETMKVINRLFYLRKCGHKKFRNRVRPCLQHFIRRCPGPCCLDVSTEEYSREIRRLEMFLSGRSAELIKGMEKDMQEASRELDFEKAALLRDQIEAVKQTTKSQSVVFPGTGDMDVFAPVYVQGGMGIGVLFVRQGKVLDSKNFFWPEHHPENDQELQDTLASLLSQFYGPDSFIPEKILLPEKIHDPALLHLLMEYRKGKVRLVGARGESLKGLLNIARQNCEQHARDRRDAGTPFLAGVMGLEREPERIECIDVSHHAGRNTRMGVVTFVAGEPHKKDYRIYNLPSVSPGDDYQAMREFIKRRSRSSSPWPDLLLVDGGKGQLGTVQKALQDAGQEGLFALASIAKAETRARGGAQDQVYLPGRKYPLSLKPASPELLYLQRIRDEAHRFALGSMRNSLRRKSLQSDLEKIPGLGPKKVEALWKHFGSLQSILGASREELMQVPGFGPETAGRTARSLKEWNTTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM39</accession>
    <name>D6SM39_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Dthio_PD3179</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3179"/>
    <dbReference type="EnsemblBacteria" id="EFI35750">
        <property type="protein sequence ID" value="EFI35750"/>
        <property type="gene ID" value="Dthio_PD3179"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087878" description="Histidine kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="327"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="640"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="901"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="16">
        <location>
            <begin position="1096"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1055"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1197"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="8">
        <location>
            <position position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI35750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1287" mass="144322" checksum="7F9470F4E91D5697" modified="2010-08-10" version="1">MPGKNHLPRKKIVIKFFCLIILLLLPWSVHAQNVELTPEEQAYLDDLGKITMCIDPDWEPYELVDDQGNFTGIAADLVDIVSQRLDIPFVIVPTKDWGETLEVSREGGCMLIPFLNQTPDREEWLTFTEPLFTNPNVFITRNEHDYIADPAELVDRTVVLPHGTSMEEYLRQDYPNLDIITVDDENECYRMVSQGEADMTLRSLTIAAFTIRRDGWFNLKISGQPPQDHYINRLRMGVLKDMPELRDILSKAIETITPRERDSIVNEHVNIILEQSFNYELLYRVSGGGIVILLGIVLWNYRLRRLRNSLKNSNEELRMAVQKVSESEETHRIIFENSPQGMFYLDASGIIVKCNDQFVELMGSTREKLIGLNSAAESPSPIDDIIQRAMGGEQTVFEGLYTSITGGKTSYLRMICNPVNPGTSPTEVIATVEDITQRKHLEESVRLKNDLQELVTEVSTDFINATWENIDGKVNNMIRRCGQFLNVDRTFVFKFSEDGLYMSNTHEWCAPGIESVNAAMQDVSLEELPANLEIFNERKMLFVPDVEQLPEGPEKQLLEAQDVKSMLVMPILRNDKILGTFGFESVSSKRLINEEHVQLLQILGNILGDALIRNSFERDLLQAKEQAEAATQAKSEFLANMSHEIRTPMNAIIGISHLALRSGLDRRQHSYLTRIDGAARSLLGIINDILDFSKIEANKLELEHVPFNLKDVLSRLSSIFDFQAEEKQLKLTFQLDPDTPLSLKGDSMRLSQVLTNLISNAIKFTSHGEIVVSVSPGTSNTAHEAIPECLPAKGYNQVCLMFSVRDSGQGMDQDQASRLFDAFFQADSSITRRFGGTGLGLSISKQLVEMMGGSIQVQSQPGEGSTFSFTVHMEKTCELEQHQSQTESHRGSTRKSLSGRRVLVVEDNRSNRELAYELMTDLGINVEVACDGLEGFKRAVQEPFDLILMDIQMPGMDGYEATRRIRSMDHRTEKMGQTSEVAEGIHESFSSLVPEPLNPGIPIIAMTAHAMAGDRDKSLNAGMDDHLTKPIEPEVLKNMLLRWMPEDRSHGAENTSQSDKSSSQVAQKASTAFQTPLPSSLPPFDISAALKRCNDNPELLRRLIKSFGREYAGAAERLRSLLQAEKLSEARILAHSLKGSAATLEAAQLMEAARDLEMVLQTEGSDNQQELLKTLENSLHPALAAAESLSGSLPEVETRQEGREDRKPGVLTPELKHALDELRHQLEFNSLKARKSFAAVQEQLRDIVGDSQVLRLAQSLEILDYQGAIKSLDELEAELGRNRDPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM44</accession>
    <name>D6SM44_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868884.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3185"/>
    <dbReference type="EnsemblBacteria" id="EFI35755">
        <property type="protein sequence ID" value="EFI35755"/>
        <property type="gene ID" value="Dthio_PD3185"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="301791at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018821">
        <property type="entry name" value="DUF294_put_nucleoTrafse_sb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005105">
        <property type="entry name" value="GlnD_Uridyltrans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03445">
        <property type="entry name" value="DUF294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10335">
        <property type="entry name" value="DUF294_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="156"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="221"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="620" mass="69412" checksum="A2FB3E1F1906415E" modified="2010-08-10" version="1">MSSEIADFLAGVHPLSGLSAEELKKAGARAGRKEVSPGEMILLDQKDHDYLYLILDGVMQILSDNEVVDTLVSGEFFGYESFFFLPPQGQAAIAIRESTLCAISGDDFRLFLGHDRMNSFFQSKAGILRNRIQDIRQWRSFSRMDPYMCLTLQDVSVKAPVTVQMDTSVSLAARIMLQEGTTACLVRQEGKFLGIVTQQDILKKVVARDLDPGSITVEGVMSSPLITVASHELLFQAFSRMVSRGIHRLVVQDSGTDPRGIIEERDLLSVKGENPVYLSREIVRAGDFSELKRVFQQVRNMVLRSVAEGVGVFQLGRLISEMHHQIQVRVHDLILAEMEQPAPASFCILALGSEGRREQYLATDQDNALIYSEASGKTQLSFFEDFSSKFIGALLDLGFPACPHEVMLSNSKWRMSIDQALDLVDDMAQSADMNSIIVTSLLLDMRHVAGDGTLAGMLKSYLFKRIRRSNLLLKYMAHEAVRFKPPLGFFNKLVVDKSGRNKGRLDIKMGGVFPLTHGIRTLAVEHAVLETPTEERISRLHEQGVFSTGFAAGLRQSFEFLQTLRVRTQAQQINSQAIPDNFISPDRLSIMERDRLKDCFKVVMEFQSLLSNKYSLRLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM62</accession>
    <name>D6SM62_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HicB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3207"/>
    <dbReference type="EnsemblBacteria" id="EFI35773">
        <property type="protein sequence ID" value="EFI35773"/>
        <property type="gene ID" value="Dthio_PD3207"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8157" checksum="328D08F1C2FCF4E7" modified="2010-08-10" version="1">MMFKYETIIYWSEEDQAYLAEVPELPGCMAHGDSYEAALANVKEAIQLWIDTAREFGDPVPEPKGRRLMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM67</accession>
    <name>D6SM67_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sodium symporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868907.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3213"/>
    <dbReference type="EnsemblBacteria" id="EFI35778">
        <property type="protein sequence ID" value="EFI35778"/>
        <property type="gene ID" value="Dthio_PD3213"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019899">
        <property type="entry name" value="Na/solute_symporter_VC_2705"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03648">
        <property type="entry name" value="Na_symport_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="591" mass="63591" checksum="04295406DD09530F" modified="2010-08-10" version="1">MSILAWTYIMVILSFGLYIFIAWRSRVKETKGFYVAGSSVPPLANGMATAADWMSAASFISMAGLVSFMGYAGTVYLMGWTGGYVLLALLLAPYLRKFGKFTVPDFVGDRYYSSTARIVALICAIFVSLTYVAGQMRGAGIVFSRFLEVEVSTGVVIGMAVVFFYAALGGMKGITWTQVAQYCVLIVAFILAAAAISYKLTGMPVPQLGFGSTLIEGERAGQYVLQAIDGIHEDLGLHRYTEAFHPGGMGMLSVVSITLALMVGTAGLPHVIIRFFTVPSVKAARISAFWALLFIALLYTTAPTVAGFARYNMIDTINDTPYTEAPSWFKNWEQTGLVAWVDKAGDGIIRFRDGDPFVGSPDLTGERGEHGERLVSNELTDNDNELYIDRDIIVLASPEMGNLPAWMVGLVAAGGLAAALSTASGLLIVIASSISHDLYYRILNPQATERQRMAVGRIMIAIAVLIAGYFGINPPGFVAEVVAFAFGLAASSFFPIIILGIFTTWVNREGAIAGMIAGISFTMMYIIQTKFMGMDPWFFGIVPEGIGTVGMLINAAVTLTVSSFTKSPPAHIRELVQNVRTPRGSGEASGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM78</accession>
    <name>D6SM78_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868918.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3224"/>
    <dbReference type="EnsemblBacteria" id="EFI35789">
        <property type="protein sequence ID" value="EFI35789"/>
        <property type="gene ID" value="Dthio_PD3224"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014433">
        <property type="entry name" value="CooC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005647">
        <property type="entry name" value="CooC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="27462" checksum="D70C3772223FD991" modified="2010-08-10" version="1">MKLAVSGKGGVGKTTISACLARLFAGHGYRVLAIDADPDSNLASALGIPPEKAEQILPISRATELIEERTGAKPGQSGSMFKLNPRVDDLPDSMSVEHDGVRLLVLGAIEKGGHGCICPQSALLKSLVSHVVLRRKELVLLDMEAGIEHLGRGTAQGVDALLVVADPDRQSIQTARTIDRLARETGIEKVLVILNKIRSSEEEELLRQGLKDMHILGVVQDSPGVRLASLKEAAPDPGDAAFTRQIEVLVNGLKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM88</accession>
    <name>D6SM88_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868928.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3234"/>
    <dbReference type="EnsemblBacteria" id="EFI35799">
        <property type="protein sequence ID" value="EFI35799"/>
        <property type="gene ID" value="Dthio_PD3234"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="203" mass="23055" checksum="2AE7AB11E5868A4D" modified="2010-08-10" version="1">MSTENYVEEKPKKLKDIRKEAEERACPVQQMQYFIDEFLDKPMCGKCYPCALGTGEAQIRVARLASRGAEVDSRDLDLLRRIGDNMVRGSLCKRGKDTGEFILELLENSRDEIMEHVDRSCPSRECKSLVRYEIVPELCTMCGECKKVCRYNAVLGETKKPYFTGYQPFEIRLKRCTGCGECVDVCPEGAIVVGSNPRKEDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMA0</accession>
    <name>D6SMA0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fhs</name>
        <name evidence="7" type="ORF">Dthio_PD3246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868940.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3246"/>
    <dbReference type="EnsemblBacteria" id="EFI35811">
        <property type="protein sequence ID" value="EFI35811"/>
        <property type="gene ID" value="Dthio_PD3246"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="177859at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="587" mass="64225" checksum="F6C62D71E308CB34" modified="2010-08-10" version="1">MALDPTKHKDWEIAEEAESRMKTVYELGEQLGLAKEELLPHGHYVAKLDYRKILESRQSKPDGKYVDVTAITPTPLGEGKSTCAMGLVQGLGRRNKSVMGAIRQPSGGPTMNIKGSAAGGGLAQCIPLTPFSLGLTGDINAIMNSHNLGMVALTSRMQHENNYTDEELAKRGLKRLDIHPKKVEFNWIIDFCAQALRNITIGQGAKMDGPMMQSRFDIAVSSEIMAILSVAKNLEDMRNKIGKIVVAYDRQDRPLTTADLEVDGAMTAWMVEALNPNLMQTLEGQPVAVHAGPFANIAIGQSSVIADRVALKLADYNVTESGFGADIGFEKFWNLKCRYSNLKPHCAVVVATIRALKCHGGAPIPVPGRPMPEEYGKENVGWVEEGCKNLLHHIETVKKAGINPVVCINAFYTDTDNEIKAVRRLCEEAGARVAVSKHWQYGGDGALEFADAVTDACEEKNEFRFLYDLETPLEKRIELIAREVYGADGVSFGPDAQAKLKRMEKDPDMKDMGTCMVKTHLSLSHEPSLKGVPKNWTLPVRDILTYKGAGFVVPVAGTISLMPGTGSDPAYRRIDVDTETGKVKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMD3</accession>
    <name>D6SMD3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868973.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3282"/>
    <dbReference type="EnsemblBacteria" id="EFI35844">
        <property type="protein sequence ID" value="EFI35844"/>
        <property type="gene ID" value="Dthio_PD3282"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="66"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="285" mass="30982" checksum="66F379514897F052" modified="2010-08-10" version="1">MRSNFARKRNQFIAFSIFRAAIYLNVLALALFLGFIAINGISAISWEFLTEHPRKSMTEGGIWPCIVGTVYISLGSILVAFPLGVGTAIYLNEFSGGGRWTRIIRMGIINLAGVPSVVYGLFGLAFFVLYLNMGVSLLAGSLTLGAFILPLIIGSAEEALRNVPQSYREASLALGATKWQTVYRMVLPAALPSMLTGMILGVSRAAGETAPIMFTAAVFYTGKIPSSIFDEIMAMPYHIYVLATAGVNIDQTRPLQYGTALTLMFLVLGLNLVAILVRNKLQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMD5</accession>
    <name>D6SMD5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868975.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3284"/>
    <dbReference type="EnsemblBacteria" id="EFI35846">
        <property type="protein sequence ID" value="EFI35846"/>
        <property type="gene ID" value="Dthio_PD3284"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027142280" description="Phosphate-binding protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="271" mass="29442" checksum="7E9FBEC303391DF3" modified="2010-08-10" version="1">MNRVLVLLGSLVFGLCLLAAPVKAGEIKINGSTTVLPVSQVVSEAFMEDNPGFNFSISGGGSGNGIAALIDGTTDIAQTSRWIRDSEVERAVENGIYPVPFVIAYDSIIPVVHPDNPVDELSLEELRKIYNGDITNWSEVGGTDRDITIISRDSDSGTYVVWSDEVLKGDRLTPRAQMLASNGAIVQTVQDNRHAIGYIGLGYLTDRLKSVKVDGVMPTSTTTASGEYPVSRSLWLITNNWPSGDVLRFINYIQHPDNAELIEEGGYVPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SME4</accession>
    <name>D6SME4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868984.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3294"/>
    <dbReference type="EnsemblBacteria" id="EFI35855">
        <property type="protein sequence ID" value="EFI35855"/>
        <property type="gene ID" value="Dthio_PD3294"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="384" mass="43061" checksum="7DD5E75925DBC148" modified="2010-08-10" version="1">MSEASIAERCSGIKPFYVMEILERAKEMEKGGRDIIHLEIGEPDFDTPECVKEAAHEAMHKGCTHYTHSLGIPELRQAISRHYQNNYSVQVDPDRILVTSGTSPAMLLLFSTLLHPGDGVILPDPHYACYPSFICFAGGRQIKIPTSREDGFQLHPDKVRKHLSRDVKAIFINSPSNPTGNLLTDQVLQELAELGPWMVSDEIYHGLVYEGRERSILEFTDRAFVLNGFSKLYAMTGWRLGYLIAPEPFVRTLQTLHQNFFISANSVAQWAAVAALEKARADVSHMKEVYNQRRKYMLERLKGMGFGIGAEPTGAFYILADAGFLSMNSYRLAFDILEKAGVGVTPGIDFGDCAEGHIRFSYANSLENIEKGMDRLQQYVNENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMG2</accession>
    <name>D6SMG2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3312"/>
    <dbReference type="EnsemblBacteria" id="EFI35873">
        <property type="protein sequence ID" value="EFI35873"/>
        <property type="gene ID" value="Dthio_PD3312"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02790">
        <property type="entry name" value="MopB_CT_Formate-Dh_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041925">
        <property type="entry name" value="CT_Formate-Dh_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="3">
        <location>
            <begin position="12"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="4">
        <location>
            <begin position="427"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="540" mass="58928" checksum="A77B1F417B7D6BEF" modified="2010-08-10" version="1">MAGLARVFGSGAMTNSINDIEQAGVLLVTGSNTTETHPVLAAAIKRAVKHRGAKLIVADPRRIRLTQFAHIWLRQNPGTDTAWINSMLHAIINEDLLDHEFVDNHTSGLDRLREHVSKYTPEYAAGITGIPPEDLIKAARMYARAPAASILYTMGITQHTSGTGNVMALADLAMLCGNLGIPGGGVNPLRGQNNVQGACDMGALPDVYSGYQKVEVPENREKMARAWNVKSLPDKPGMKLTGMLAGSGENAVKALYVIGENPALSDPDAQHTRKALQDLEFLVVQDIFLTETASMADVVLPACSFAEKDGTFTNTERRVQRVRKAIEPVGHSRPDWMIIQDLASRFGFFMHYQSPQDIMQEIASVTPSYAGINYSRLEKKGLQWPCPHQDHPGTPILHSQGFAAGRAGFQCVEYTPPEETIDEAFPLWLTTGRSLYHYHTGSMTRKIRGLNALERECCLEVSPQDAHKAGLKDHDRVSVRSRRGEITTRVRISSAAVPGAVFIPFHFAEAAANVLTNPALDPVAGVPEYKVCAVRIGIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMK5</accession>
    <name>D6SMK5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869044.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3357"/>
    <dbReference type="EnsemblBacteria" id="EFI35916">
        <property type="protein sequence ID" value="EFI35916"/>
        <property type="gene ID" value="Dthio_PD3357"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1674498at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="32433" checksum="F11711FE62DBB759" modified="2010-08-10" version="1">MEISVSLIRQLDQVDPDLRNILFAILEEFERQSKERVTKDEFRELRQTVHELAQAQARTEARIDELAQAQAKTEARLDSLVQRVDELAQAQARTEARLDSLVQRVDELAQAQAKTEARIDELAQAQAKTEAEVRKLAMSHRELKTQVAGLSDSVGYGLEDRLMPYIPEYARLEFGLEVESLDRKNVIYPDGRYDEVNILARGSLNGETACLVGECKAKPGKKDADRFASLLERLSTVLEGRLIPVLIGYTFAPEVERHVSRKHPHIRLVKTYALEMRARGDRKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMR3</accession>
    <name>D6SMR3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869102.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3416"/>
    <dbReference type="EnsemblBacteria" id="EFI35974">
        <property type="protein sequence ID" value="EFI35974"/>
        <property type="gene ID" value="Dthio_PD3416"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="195" mass="21816" checksum="0EDD92A1CEF2BBB0" modified="2010-08-10" version="1">MADSRVMVLGCSPRKEGNSDKAAGEIADTLEGRGCRVESIFLRDKKILPCMGCRKCETTKNNRCILAGKDDVQEILDKMQESDLVFFSCPIYYYHVPSTFKALIDRGQSVYEAWAAKGEPGLELKQAYCVLIAGRKKGERLFEGSLLSLKYFLYPLGFALKDLCLRGIDLREDLAGDQDSREKIREFARSAAGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMU6</accession>
    <name>D6SMU6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869135.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3449"/>
    <dbReference type="EnsemblBacteria" id="EFI36007">
        <property type="protein sequence ID" value="EFI36007"/>
        <property type="gene ID" value="Dthio_PD3449"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="575" mass="63129" checksum="3F7ABC45E687D0C8" modified="2010-08-10" version="1">MKTIFGIDLGTTNSCISRLSQGVPEVISINGSPLVPSVVSFDQGETIVGTRAKNREVLYPETTVSSVKRIMGTRQTIPVQDSEYTPENISTFILTYLKEQAREICQEEVENVVITVPAYFSDAQRRATQQAGEAAGLNVERIINEPTAASLFYNHVDTPGKQDRPESRVLVYDLGGGTFDVSVLRMGELSEVLASTGNTSLGGDDFDQAIVNLCLEQIMSTYGTDLRGHRPALARLKDAAEKAKIALSAHPFTFIEESLIPSPSSEDINLSLEITREEFESMISPYLETTRQEMQKALQEASLAAGDIDSVLLVGGSTRIPAVISLLEEYFGPSCLPPVDPDLSVAKGAAIQGGIISGSHIHQVLIDVNPHTLSTEVLEDPVSMKLKCVPIIPRNTQIPVTRSELFYTVFDSQPLVRVSVYQGESTQSGENTHIGSIDLQLSPAPSGTPINIEYSYDLNGIIRVRVEQKGYSVKREVDLDSSRQDQMFLKVDLDSDPDMDDQPDESPRGSQQTTNYILHKARGMLDELSGDASRNTLKSLIKDYEDALQGDDEDAVDEAEETLVDYMDELQEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN04</accession>
    <name>D6SN04_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869193.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3510"/>
    <dbReference type="EnsemblBacteria" id="EFI36065">
        <property type="protein sequence ID" value="EFI36065"/>
        <property type="gene ID" value="Dthio_PD3510"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HPA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2002372at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="192" mass="21671" checksum="6A9E71739550D49D" modified="2010-08-10" version="1">MTYEIKEHKHRYAAWAASRASSVKGCRFSVLQGKMIIENSGLSTFVDSPQNLPETNSFDKVHSDWRESVILQAEKLGLNFTHGVAAKLINVYMKTIFVCGGYAENERVAPIHPPIDGLLLKSLRDNDVGGLKKEWRKAVTKRWSKFDSDEYQSVIGNIRKALNGSPMWKIEKYWQGYQGSTAMKSMQPTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN31</accession>
    <name>D6SN31_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869217.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3539"/>
    <dbReference type="EnsemblBacteria" id="EFI36092">
        <property type="protein sequence ID" value="EFI36092"/>
        <property type="gene ID" value="Dthio_PD3539"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032GKV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1832080at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="259" mass="30029" checksum="44D80C8626C4EADB" modified="2010-08-10" version="1">MLQAINQGKSNFYKRYVGHREKGERVSEEDELTSLILGPLELIPGHLSAIFWGTLLSEFKIPSVPSNFPEKAEIAFWKSRKNFMTGKPIEPDIVVDLKWPSGESFLLLIEMKWHSPLSGKDQLQIQWTEFLSEEERSKALHLFIAPETSEASKARRARDVWSGRLLAISWFDILCILQDKIRKRDPVYEPLMPWMTQVVALLDKLGIRPFRGFKNLKLPEYSISKESKHLFWNGFIGFTYLAQPALITTNDQIFFNNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN39</accession>
    <name>D6SN39_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869225.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3548"/>
    <dbReference type="EnsemblBacteria" id="EFI36100">
        <property type="protein sequence ID" value="EFI36100"/>
        <property type="gene ID" value="Dthio_PD3548"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2031781at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="125" mass="14107" checksum="F919DCB179260A6F" modified="2010-08-10" version="1">MNIISSSDMEIYRKSARKRLQALRESRRIRHEHAWDVARRAASLLREHFAASRVVVFGSLLRPEVFDERSDVDLAVWGVADEKYLRAVAAVTALDKEISVDLIKMEPGLQSNTAISSQVETGVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN56</accession>
    <name>D6SN56_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0472</name>
        <name evidence="6" type="ORF">Dthio_PD1530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0472"/>
    <dbReference type="EnsemblBacteria" id="EFI33149">
        <property type="protein sequence ID" value="EFI33149"/>
        <property type="gene ID" value="Dthio_PD0472"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34182">
        <property type="protein sequence ID" value="EFI34182"/>
        <property type="gene ID" value="Dthio_PD1530"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="60" mass="7185" checksum="7B0BA37FF06D0846" modified="2010-08-10" version="1">MKRHQLIKHLQVHGAYLLREGSKHSIYQLDRKKTQVPRHNEIVDDLARKICKDLNIPFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN60</accession>
    <name>D6SN60_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0081</name>
        <name evidence="8" type="ORF">Dthio_PD0089</name>
        <name evidence="9" type="ORF">Dthio_PD0454</name>
        <name evidence="10" type="ORF">Dthio_PD0486</name>
        <name evidence="11" type="ORF">Dthio_PD1535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869516.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0081"/>
    <dbReference type="EnsemblBacteria" id="EFI32784">
        <property type="protein sequence ID" value="EFI32784"/>
        <property type="gene ID" value="Dthio_PD0081"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32791">
        <property type="protein sequence ID" value="EFI32791"/>
        <property type="gene ID" value="Dthio_PD0089"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33136">
        <property type="protein sequence ID" value="EFI33136"/>
        <property type="gene ID" value="Dthio_PD0454"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33163">
        <property type="protein sequence ID" value="EFI33163"/>
        <property type="gene ID" value="Dthio_PD0486"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34186">
        <property type="protein sequence ID" value="EFI34186"/>
        <property type="gene ID" value="Dthio_PD1535"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="105"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="322" mass="37012" checksum="D4E51FC205511297" modified="2010-08-10" version="1">MKKFESFLAGHLNDFIQYRKELGYVNKSLANQLRALDYYVRDNARGWEDLTPAFFLGFRDGIKGSPATVNNVIQATRNFFAYLHRTGCCEHNPVQDLPAKTENAFIPFIFSPEQVEQLLQGVQSQIRRSREKCFLVDMGIYIALMLQARCGLRMSEPLNLGLEHFDPVQGTIYIQKTKFHKDRLIPIPWEAQKELDNFLSLRDALCCTSPYLLPGFKNALRTNQVYPVFHRAVRETGIHAPRRIIANMVFGHPTPHSLRHSFAVNTLKAARDRGRDPQAVLPVLSAYMGHSKYRYTALYLKVMDAEKRQGFVDFAISRLEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN63</accession>
    <name>D6SN63_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1538"/>
    <dbReference type="EnsemblBacteria" id="EFI34189">
        <property type="protein sequence ID" value="EFI34189"/>
        <property type="gene ID" value="Dthio_PD1538"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032T9N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1455603at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="148" mass="17651" checksum="5E8DD4D488D54F20" modified="2010-08-10" version="1">MSKKRCRYCRCLFPLTKRNPDQKYCSKPDCQRARKRRWQRKKMQVDQAYRLNKRASDQRWSARNPDYWNNYRENNPGYTRSNREKQRYRNRRRRAIESISSEIAKLDALSAENSDISGTYAMISVQDLLIAKMDAKIVKITEVSMGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNJ7</accession>
    <name>D6SNJ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869651.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1674"/>
    <dbReference type="EnsemblBacteria" id="EFI34323">
        <property type="protein sequence ID" value="EFI34323"/>
        <property type="gene ID" value="Dthio_PD1674"/>
    </dbReference>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002322">
        <property type="entry name" value="Cyt_c_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020942">
        <property type="entry name" value="Cyt_c_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02085">
        <property type="entry name" value="Cytochrom_CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00609">
        <property type="entry name" value="CYTOCHROMEC3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrom_CIII" evidence="4">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="160" mass="18265" checksum="5E54AC496B0ED5C3" modified="2010-08-10" version="1">MRKSVVIGTVVAFFFGFLVLPSIYAGLTTQHEEKDQDMEYEFGSYADEWMLYAPEEYVEEEGEMEYDPVPFSHTVHGDYDCGECHHDEQGDPLDETNEITGCMSEGCHDMAVAEDADDERDIRYFEKAYHDQCMDCHRDMTREGEETGPVACNDCHTGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNM5</accession>
    <name>D6SNM5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenium metabolism protein YedF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869679.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1702"/>
    <dbReference type="EnsemblBacteria" id="EFI34351">
        <property type="protein sequence ID" value="EFI34351"/>
        <property type="gene ID" value="Dthio_PD1702"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019870">
        <property type="entry name" value="Se_metab_YedF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03527">
        <property type="entry name" value="selenium_YedF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="205" mass="22211" checksum="8DF547A1BF1180A4" modified="2010-08-10" version="1">MSRHEKVDCRGLPCPQPVLKSREIIDSINPDTLQVQVDNEPALENVSRFLSTQGYALEKPEKNGDIWTIHASRGEAPATGSHEAAAPGPGAGETLRTMVFVSTSRLGTGDDELGSKLMQNFIKTLPEMGSSLWMLVFVNSGVKLAVKDSPVLETVQRLEENQVKILVCGTCLEFFGLTDAKDAGQTTNMLDIITAMSHADKVITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNP7</accession>
    <name>D6SNP7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869701.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1725"/>
    <dbReference type="EnsemblBacteria" id="EFI34373">
        <property type="protein sequence ID" value="EFI34373"/>
        <property type="gene ID" value="Dthio_PD1725"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="661935at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019065">
        <property type="entry name" value="Res_endonuc_III_NgoFVII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09565">
        <property type="entry name" value="RE_NgoFVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="677" mass="79219" checksum="C704915C33691F47" modified="2010-08-10" version="1">MTKKQARPGQLPRQGAQPQTLYLQKPKDFEGLISGYKEIRAVSYVASPTLMLSIFEKFQFEYMQLLVGENISVKHYKKDLENKQISLIQKLMHLVKEQKLTVFFPRGKTIHSKFYILKNEDMYRVIVGSANFSEPAAKATKQHNYVVYWDLKSPDPLLEKFVQDYKEHLKNSRLFLDDLIKLAENRDEDEEKVIRTWLSQDVGEVKDLAESETSRVFTDLTRQALSTVDNNEHSENPDTGEPDEEQPASGEIRVIIPSDVKTQEGIEKKLQPLKPSIVKSELRLSARDFSDYVKRSCGVPLMGTHRSSRQVFLHMGDYRGVLSRPVHSREEVRQGLEYIEEYVESYGFGESIDHKRIQANVFEALLYVLSAPFAHEFKKLKKQVDMYSRGPSYLYLYGPSFNGKTNFLRFCLKLMAGRHLEPIAQEYFNKTRIMSAKMFGTVFPLMFDDVNIGSGSNIETVLKNYWEVWWNPGHPVPQIIMTTNRFNPPEWANTRIKRINFDVKFDQKNIQASETLNRILNTDCDFFKLFAHSYLEKLDQPIDNIKEDLLVDELSLSRKIFADFYRFAERSVPDYFPQVPVDKLYDIDKMEWQELFATKVLTQEEHGNKIFVHADKTVHTYEVERFMRLLPQGVKAKRKAHTIIIEGRDKYLEWINAGKRDQGFWKNLMNRFKRTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNT8</accession>
    <name>D6SNT8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869736.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1772"/>
    <dbReference type="EnsemblBacteria" id="EFI34414">
        <property type="protein sequence ID" value="EFI34414"/>
        <property type="gene ID" value="Dthio_PD1772"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10958" checksum="7BC2D3AA2C23EF23" modified="2010-08-10" version="1">MIEFDWDPQKARANLEKHGISFEEAKSVFFDEYARQFFDEEHSSSEERFIMLGLSNVLRVLVVCHCERSGGGVIRIISARKATANERKHYEGPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNY4</accession>
    <name>D6SNY4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869782.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1819"/>
    <dbReference type="EnsemblBacteria" id="EFI34460">
        <property type="protein sequence ID" value="EFI34460"/>
        <property type="gene ID" value="Dthio_PD1819"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1209463at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="314" mass="35734" checksum="C1C5DF4371ADAB0E" modified="2010-08-10" version="1">MLTYTPLTLDPDRILDVDPCIFWAGECTKPLFDSLQGQGQLQPVLVQKSSTGYTLVAGYSRFQGLKKLGKKIYALQTEDPGPWEKGLIYLSSNLGRIPDTLMLVRAMRYFSPLGKDLQQIYLLLGISRGSRQERQLQAWTRLPHEWDGALQHTPQLLTCAPDLANISHSDLDTLLPFFQDLSWSLNNARKFLDLLRRTQQPENLPIEEVVTRLALDKILAGELSPKDKIRLILDSLGRAAYPEYFRLMDEARQNINSLVAGTAWNCTHSDNFESPGLELRVRVHNRDELQEVSRQLKSIASSTHLSPWPVYPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNZ9</accession>
    <name>D6SNZ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaA</name>
        <name evidence="14" type="ORF">Dthio_PD1834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869797.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1834"/>
    <dbReference type="EnsemblBacteria" id="EFI34475">
        <property type="protein sequence ID" value="EFI34475"/>
        <property type="gene ID" value="Dthio_PD1834"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="144"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="13">
        <location>
            <begin position="357"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="152"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="449" mass="50873" checksum="869B5B654015CE04" modified="2010-08-10" version="1">MTDAWERIQIILEKSLKSGIFQLWIKPLQGSFDPDAKILRLQAPNEFVASWVRERLQSMILEAGQDVLGVTPELEISAFRADEAASPLGSPEKAGASETRMHLPIQSNIQVVSRFRYSFQDFVVGPSNELAFVASRSFCREQVSSDQLFLCSSTGLGKTHLVQSMGNNLAGSSNKEALRVAYLTAEEFACQLIQAIKSKQVERFKARYRDQIDILMLEDIHFFQGKEKIQGEFLSTINSLQGQGKKVVLSSSFLPKELNDLDSNLVSRLCRGFMAVIDKPDLGTRQEILRQKASSLQISLPQEVSHLLAERIQTDIRQLESCLSNLVFKARMLKERITLEMALEVLKNYDLKEQNLDLEEIIRSVCRVFDLPREKVCSKSRKKQHVLARNLAFYLARKYTGHSLKDIGRRFNRRHSTVLKGVANVEKEVNTDTPLGRQLKDAASRVMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPA2</accession>
    <name>D6SPA2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <shortName evidence="6">UDP-N-acetylglucosamine acyltransferase</shortName>
            <ecNumber evidence="6">2.3.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lpxA</name>
        <name evidence="8" type="ORF">Dthio_PD1950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:67812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="2.3.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transferase hexapeptide repeat family. LpxA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.129" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869898.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1950"/>
    <dbReference type="EnsemblBacteria" id="EFI34578">
        <property type="protein sequence ID" value="EFI34578"/>
        <property type="gene ID" value="Dthio_PD1950"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="971098at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00387">
        <property type="entry name" value="LpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="7">
        <location>
            <begin position="177"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="270" mass="29270" checksum="0437F83197E7F382" modified="2010-08-10" version="1">MKTQIHPTSIVHPEAELGPGVVIGPYVIIEESTSLGEGTRVDAFAQIKKFTSLGRNNHVYSYACIGEGPQDIKYQGEETWLRLGDDNKIREYTTLNRGTPDGRGVTSIGSGCFLMAYTHVAHDCILEDGVIMANGATLGGHVHLGQKAVIGGLCAVHQFVRIGEYAFIGGKSGIAQDVPPYMLAVGERARLVGPNLIGLRRAGFPREEISALKKAFNLIWKSDLSHVQALEKAGQDFSGLRLTDNLVSFLKSSSRGVVSLERNPERNGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPB9</accession>
    <name>D6SPB9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869915.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1967"/>
    <dbReference type="EnsemblBacteria" id="EFI34595">
        <property type="protein sequence ID" value="EFI34595"/>
        <property type="gene ID" value="Dthio_PD1967"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1958004at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="12152" checksum="AE75F2D745DAFAF9" modified="2010-08-10" version="1">MNERYLIQKIATCDKCHGHGKVENPLWTELIEEVGEDYLKNLSKQDYNQLLIEKGLLSFGRYEPREMKCKNCKGSGEFFNNVNLEDVPVVQDLMKRLENLENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPF7</accession>
    <name>D6SPF7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NIL domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869953.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2005"/>
    <dbReference type="EnsemblBacteria" id="EFI34633">
        <property type="protein sequence ID" value="EFI34633"/>
        <property type="gene ID" value="Dthio_PD2005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="16275" checksum="1FE7C57F5F1C2A02" modified="2010-08-10" version="1">MQTAEEFSKIISLHFSPEVVRKPMMYNLAKKFDLTFNILKAKISPREEGHMILELSGDLEDYKKGVSYLQEHGISIRDVAQSMTRDESLCTHCGVCTALCFNRALRLDKATRKILFDEDKCTACSNCTRICPVGAMQVESNGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPH2</accession>
    <name>D6SPH2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="11" type="ORF">Dthio_PD2020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869968.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2020"/>
    <dbReference type="EnsemblBacteria" id="EFI34648">
        <property type="protein sequence ID" value="EFI34648"/>
        <property type="gene ID" value="Dthio_PD2020"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="42703" checksum="4F893CAEDFBE88F5" modified="2010-08-10" version="1">MQFIDDLDVSGKTILMRVDYNVPLKDGRVQDDSRIQASIPTIEYALRQNARIVLCSHLGKPKGQVRSELSLAPAAERLSAILGRDVALAPDCIGEKALEMVRSLEPGQILMLENLRFHPGEEKNDDEFSRELARMGDIYVNDAFGVSHRAHASVVGVTRHAPSCSGGLLLKKEWEYLSKVGDPARPFVLIAGGAKVSSKLGVLENLMHKVDTMLIGGAMANTFIKAQGYSVGTSKVEDDLLDKAREIMQKAIENKVQFYLPVDFMLGEGPDAESAEGVCPFQGIPGHLMALDIGPATCTLFSEVLHKASTVIWNGPMGAFENRPFSQGSRNIAELVSGLKATTMVGGGDTDSLIHELMLQDKFSFISTGGGSFMEFLEGKTLPGFKALEECSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPM3</accession>
    <name>D6SPM3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type uncharacterized transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870019.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2071"/>
    <dbReference type="EnsemblBacteria" id="EFI34699">
        <property type="protein sequence ID" value="EFI34699"/>
        <property type="gene ID" value="Dthio_PD2071"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="859404at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088259" evidence="1">
        <location>
            <begin position="29"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="352" mass="39666" checksum="1C56403CD198B5C2" modified="2010-08-10" version="1">MLKFFRLQNMAFICLILAGILLASPALAQEKNYRVGYIEGGSYWLFSDSLQAVKDSLQARGWLEKIDFPGDAHYSPGWDRDELLEQEARELMQRDDLDLVLAAGTDATRAILAANNHETPIVAMAVSDPVDSGFVQSTQDSGVDNFTVRLDPERYPRMFDIFHQIVEFDRLGVIYPDTESGRQFTNLGAARRIAAERGFELLEYDRITTESVQDCLEGIRHLLDKGMDAFFIPSLLAFDWESSDVDKILSFLREQGIPTFARNGSRDVEAGALMGFSTVDFSRRGNFLSQMIIDILEGKKPRSLNMVDRGAPKISFNIQVANEIGFNPPFELLAATDELYREISLPEDRLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPN0</accession>
    <name>D6SPN0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870026.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34706">
        <property type="protein sequence ID" value="EFI34706"/>
        <property type="gene ID" value="Dthio_PD2078"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XT2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="375" mass="42212" checksum="701875B5B47B8273" modified="2010-08-10" version="1">MRIYESEAEVLIWPYHGMKSPGHAALKIRTNKDGEVYQTYVSWWPAGGEGKNTPFSYRPAEAQPGYYKDKFLEMSASTRNRLNDGEINRDPRRFQKVSQNPNTALEFVTSANKKFNLPGLFSRVGRTRKSGAGIDGFDNVAGRSSLADGEYTYWGLNLPGMVKWWMDFSDTPKGYSFVSTKYNCAAVVAQCLLEGCADAYIDIKQPKMYYTPNDISALADKLVNRLDDLNIESRRLINNSRQSLDRPGIWTSEEFYKASYAGRFARRKGQVASIDDLLKEYHKAGPWDENNFPQKFKALGRMMRNVLDHRQKKAGSDRGGAVETLGLQILAELSSEELLIAQNNNAGGSLAALLSLCEEGNNRTLDQSFKKAKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPP6</accession>
    <name>D6SPP6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870040.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2095"/>
    <dbReference type="EnsemblBacteria" id="EFI34722">
        <property type="protein sequence ID" value="EFI34722"/>
        <property type="gene ID" value="Dthio_PD2095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="137" mass="15669" checksum="2AB29D36C474F325" modified="2010-08-10" version="1">MQQDFQDKEQKNKGWSGEDKKQELFSIDKLRKRWSRNSIGSDCLDTAPACLGNHCGFLLTLLEDLRIMVRRELVGSDSLEILEERIDAMSAMIQLPQEEIQEPEASIHESNLDYQALGKMAAELEDLLEAVLFDQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPR7</accession>
    <name>D6SPR7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870061.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2116"/>
    <dbReference type="EnsemblBacteria" id="EFI34743">
        <property type="protein sequence ID" value="EFI34743"/>
        <property type="gene ID" value="Dthio_PD2116"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087912" evidence="3">
        <location>
            <begin position="28"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="32"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="372" mass="40985" checksum="E86298B9F5870B57" modified="2010-08-10" version="1">MKSFLPVQLLLIMLLLLNLPSCGGSSAGDEELADKVGQMLMIGFRGLVVDENSPIVRDIQNGLVGGVVLFDYDVALESPARNVQSPDQLRKLVADLQAAGPDTLLVAVDQEGGRVARLKEKYGFPPTVSQQWLGTADDPELTYEYASKTAVTLKDMGINLNLAPVVDVNVNPDNPVIGRLERSFSSDPEKVAVHAAEVIKAHRDKNILTALKHFPGHGSSTRDSHHGFTDVTNTWQELELKPYELLFDSPGMDMVMTAHVFNARLDPQWPATLSPAVLTGMLREDLGYEGVIISDDMQMGAIHDEYGLETALEQTIKAGADIIIFGNNLVYDQDIAWKARDIILDLVRAGQIPRERIDESYERIMQLKSKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPX8</accession>
    <name>D6SPX8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870120.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2185"/>
    <dbReference type="EnsemblBacteria" id="EFI34804">
        <property type="protein sequence ID" value="EFI34804"/>
        <property type="gene ID" value="Dthio_PD2185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088146" evidence="1">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="432" mass="47568" checksum="61FF080DE58CA811" modified="2010-08-10" version="1">MKTFKLFIVLMLCIVSISIAVSGWGDAPGAGEETEDPEDFTTAKEMMEHGDVPSGFDKELEFTTQEEFEFLVENGLNGRNTEDITLDNGYTIKEGKFTMSWGEKALLAPGAITDENGNEIGGGEMDISEIMDGNIPAANELEHQTPEGDISSGQGIGGFSMLGSDYTIDYADYWETDSHKIVEGHGIQKKGGNIYVDEGHAIDSDDEFVSYANSYESSGNEFSIGEAKAVLLDGTLFTDIKDSYFKTKDGAITEASVTSSTDDNSFTLDGITVEMDENDTFNAKLDEETGKFDLSLDSEQGKIEATYPNVGCVEISPGSRFEYTGSDFDDFALFVPSYGGVYELCIRTLPEENYTSDCSRCGVKDFVNKTAEFNGIYQYEKPSVFEDDIFRNMIDASGNYSMEADNHKFNNTYIFRRSHGDAALEHKAPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ04</accession>
    <name>D6SQ04_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2220"/>
    <dbReference type="EnsemblBacteria" id="EFI34830">
        <property type="protein sequence ID" value="EFI34830"/>
        <property type="gene ID" value="Dthio_PD2220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="47" mass="5381" checksum="86AEE0F853740215" modified="2010-08-10" version="1">MTQIKEGSIAIDFSQALKVRRFDDINRGLSFCMKAVDFIVELEKSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ64</accession>
    <name>D6SQ64_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870204.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2281"/>
    <dbReference type="EnsemblBacteria" id="EFI34890">
        <property type="protein sequence ID" value="EFI34890"/>
        <property type="gene ID" value="Dthio_PD2281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="147"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="414" mass="46953" checksum="25D22EE93E42A5B5" modified="2010-08-10" version="1">MGRILVDDIKPGMVLDDDVRDFNGRFLLGKGLSVQEKHLRIFKIWGVSEVTVQGDGAEQDDEPEEFSREERRQAASQILERFPHYDPQHKVSRKLLEIFILWKCRYPGGFYTSDAWHEALDNHTPPSERNRGEPVDPSVIIRDETRMPSLPDIFFQIQEAIQDPRTSARHLADIISKDQGLTSRLLKLVNSAFYGFPSQIDTISRAVAILGTRQLSMLAMGVTVLSGFKSISPDIIDMKGFWKHSLACAIGAKTLAQYRHLSNTESIFICGLLHDIGRLLMLRYFPRETLWSMHLAATEKLELARAEKKFFRQDHAQLGAAIMKNWKLPLKLEQSIRHHNSPGKSSFPIETTLVNMANVLSSGCLMGFSGEYMIPAPDLESWDALNLDPAVLLQTAKLMQSQADNLFQLFFDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ65</accession>
    <name>D6SQ65_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl transferase family 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870205.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2282"/>
    <dbReference type="EnsemblBacteria" id="EFI34891">
        <property type="protein sequence ID" value="EFI34891"/>
        <property type="gene ID" value="Dthio_PD2282"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PMT_2" evidence="8">
        <location>
            <begin position="50"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="496" mass="56384" checksum="E632322BCF0A5577" modified="2010-08-10" version="1">MNYIQARDFFYFALFLSLPLKLILAGTLPLTGDEAYFVIWAQHPAAGYYDHPPLIGWLIHLCMYISGHEILVRLPSILASYVLVWGVYRILSDHDRTKALLAASTLLLTPVFLLGVLVTTDTALILSMFLSVLALHRAETRNSNLLYILSGILLGLAFLSKYFAALLLLAYIFYFLTGGLKKLPRLGLVLLGCLPLVAFNLYWNYTHCWVNIMFNFIGRGGDAEFSPMQPLILLGMLAWVVSPVLLVQLFRHRSQVLSRIRSSGHGLFAFAALVPLAVFFAASLFYSVGAHWILGFVPFLYVIYAALPGKSLILGRKFMLGYALLHIVLVAAALLVPLEIIKERPGLYRDAVFYLRPAQVAEKLDSYRADYYATPSYSRSAVISYYSSHYWGILGTGSRYGREDDRITDFRKLDGRDILFLSRDDELDKDRLSPYFEFLEPSRIQVRETSFAVALGRGFDYSSYQSQVLAQIKKRHYDIPDFLPLGRCFFHERYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ93</accession>
    <name>D6SQ93_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisC</name>
        <name evidence="8" type="ORF">Dthio_PD2310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870233.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2310"/>
    <dbReference type="EnsemblBacteria" id="EFI34919">
        <property type="protein sequence ID" value="EFI34919"/>
        <property type="gene ID" value="Dthio_PD2310"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="7">
        <location>
            <begin position="36"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="368" mass="41185" checksum="97694ED050731155" modified="2010-08-10" version="1">MSENFSPFIREEVKSFKPYSPGLGIDEIKHKYGLSRVIKMASNENPLGVSPVVQETITRNSGLAFRYPGANNPELCRAVAGHLELDPACIVCGNGSDELIDLLIRMLLVPGRDNIVAFDPCFSIYRLQARLSGVEFRQAKLNPDFSFNLKELLKLVDANTRVVFLTNPDNPSGYAAPASELDRFASQLPHGCCLVVDEAYIDFAMPREHYSMLSFFKNDSNLVVLRTFSKMHALAGLRLGYAILPVILADYMRRIRLPFSVNILAEKAGQAALKDSDFTRESLSIITRGRKFLSVELENLGCSVYPSQANFIMFQPPVNAGHIFQELLKRGVIIRPLDSYGFSHLLRVSIGTREENETLIKYMQEIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ98</accession>
    <name>D6SQ98_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fimbrial assembly family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870238.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2315"/>
    <dbReference type="EnsemblBacteria" id="EFI34924">
        <property type="protein sequence ID" value="EFI34924"/>
        <property type="gene ID" value="Dthio_PD2315"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1673053at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="195" mass="22548" checksum="24829551A84BF5E4" modified="2010-08-10" version="1">MIKINLLPHSKRARVKPAEKQLILGLGLIVCISLVCAVFILWSGSRVSSLENRVADLDEQRHELLQQVRHINEIKDKMEQMQSNIRAIKDIRTIQPLPVRYIETLVINLPDQRIWFESMDLDPDSTLEIRGVVLDNQVFARYVDDLRQSPYVHKVNTRRTSRRQVQDLDLVEFDFLVQAGEPLPGELTLQGSNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQA0</accession>
    <name>D6SQA0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870240.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2317"/>
    <dbReference type="EnsemblBacteria" id="EFI34926">
        <property type="protein sequence ID" value="EFI34926"/>
        <property type="gene ID" value="Dthio_PD2317"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="145" mass="15782" checksum="A9E370CA77F3E0F8" modified="2010-08-10" version="1">MAEVKKILCAVDFSDMSSKVADYAQTIAKSMNSSVKVVYIAPSLSQYVGFHVPPTSIENFVGEIVSGAEKTMDIFIQENFSEVDATGQVLTGYAAEEILKYADQEDMDMIIMGTHGRKGIDRVLFGSVAEKIVKSAPIPVLTIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQA9</accession>
    <name>D6SQA9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic dehypoxanthine futalosine synthase</fullName>
            <shortName evidence="6">Cyclic DHFL synthase</shortName>
            <ecNumber evidence="6">1.21.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dehypoxanthine futalosine cyclase</fullName>
            <shortName evidence="6">DHFL cyclase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mqnC</name>
        <name evidence="8" type="ORF">Dthio_PD2327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33083"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="1.21.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.1" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2327"/>
    <dbReference type="EnsemblBacteria" id="EFI34935">
        <property type="protein sequence ID" value="EFI34935"/>
        <property type="gene ID" value="Dthio_PD2327"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046992">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00992">
        <property type="entry name" value="MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022431">
        <property type="entry name" value="Cyclic_DHFL_synthase_mqnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03699">
        <property type="entry name" value="menaquin_MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="59"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="362" mass="41561" checksum="D58E6E51A191387E" modified="2010-08-10" version="1">MYSLNPESLFPHENRLDRGKSMQRINLDQAQKLWQEQNLFDLGRMAHEARKKLHPEDVVTYIVDRNINYSNICISGCKFCAFYRPPGHHEGYLLTFEQLEQKILETIELGGMQILLQGSINPDLDLDWYEKLLRFIKDRFPDLAVHGFSPPEIFYLAGRENISVSRVISRLKKSGLDSIPGGGAEILVDRVRRKLAPRKCTARQWLDVMHEAHNQGLKTTATMMMGHVETMQERLEHLQKIRDLQDMTHGFTAFIPWTFQPGNTLMNVSEASSVEYLKFLALSRLYLDNIPNIQASWVTQGAHVGQLALMWGANDFGSTMIEENVVAAAGVSFKLPEDKLRLLVQKSGFQPRKRRMDYTLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQD9</accession>
    <name>D6SQD9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD2357</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870279.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2357"/>
    <dbReference type="EnsemblBacteria" id="EFI34965">
        <property type="protein sequence ID" value="EFI34965"/>
        <property type="gene ID" value="Dthio_PD2357"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2086136at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02473">
        <property type="entry name" value="flagell_FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="159" mass="19146" checksum="8DB585EC06F7F282" modified="2010-08-10" version="1">MRKNFIFSLQKVLDLRRQQEDKAKEALALARKRYQEQNQVVQEILEERVRARQSMEEKQDITQADIWLYNLYRDRLNLDLVKAEEKLGRLSRDINQKRQELVEKSKQKKVLERLKHNRKVKFDHEQQQEEQKEFDEMAVLRYQPEALQAVADDHGIGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQP0</accession>
    <name>D6SQP0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870380.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2460"/>
    <dbReference type="EnsemblBacteria" id="EFI35066">
        <property type="protein sequence ID" value="EFI35066"/>
        <property type="gene ID" value="Dthio_PD2460"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="589228at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="363" mass="41047" checksum="714C4D25011EA606" modified="2010-08-10" version="1">MTKHDIRPIDKLQNPDELGFKALEPLDPDNIQDFDQLLQAMEKTAFSGRSLGEALNVLQEMVTDPDCLVVGTFSGAMTVAKMGKLLCKMIDEGWINVVISTGALMAHGFIESIGLKHYKYEKHRMNDQELFKMGFNRVYDTLEPEINFMRAEDIVHQVMQGIDKEEQLSSEILCRKIGRYLDENIPGPGILKSAYQQNTPVYIPAFTDSELALDIATHILRQQEKGPTLEPDTYPPFPFNPFLDLFSYTKKITESKKIGLFTIGGGVPRNWAQQVSPFLEIASQRLENLELPLRRFQYGVRICPEPVHWGGLSGCTYQEGVSWGKFTPREQGGKYAEIYSDATIAWPILIKGLQDRLAKKGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQT7</accession>
    <name>D6SQT7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheW protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870427.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2507"/>
    <dbReference type="EnsemblBacteria" id="EFI35113">
        <property type="protein sequence ID" value="EFI35113"/>
        <property type="gene ID" value="Dthio_PD2507"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="96"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="27233" checksum="674AF0A1CD206D40" modified="2010-08-10" version="1">MKTPEQYFQEQVFDSDALLDQKEVSDQEQAFIQKYLGELAENLPDVGPQARQTHAFPPPAKEESVDAGDDEQTFEGGREEKYGAAGLSEDLRRRQEVQLVSFFMGQQEYALPIDAVQEVIKYIQPSRLPTAPAHVEGVINLRRKITPVVDLPGFMRIKKSDRDEHRFMVVCRHSGFQVALLVERIATMYRISDSDIEWNVDSALGGGSGVVEALIKNRERIISVLSIEKIVQHLLGDHKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQU4</accession>
    <name>D6SQU4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">nnrE</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="18" type="ORF">Dthio_PD2514</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870434.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2514"/>
    <dbReference type="EnsemblBacteria" id="EFI35120">
        <property type="protein sequence ID" value="EFI35120"/>
        <property type="gene ID" value="Dthio_PD2514"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748633at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="11"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="132"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFI35120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="525" mass="57866" checksum="C3D6A46C5D519E27" modified="2010-08-10" version="1">MYLPLPTPQEMAAWDKRSMDDFDLRPELLMENASREAFSQIKHRFADLAGRSALLFAGPGNNGGDAFALARHLWISGVKVMTLHSKRLKEYDGASGYHLSVLRKLEVPYAHLSEYNFDFIRDVDIIVDGLLGTGFTGELRQDYVDWIKSINKMGEKAYVISLDIPSGIDGITGEPSPVAVRADDTVAFEEAKLGLMQPEAREYVGCLSIKKIGIPQSIKHDSPPEHYVLDVDILDRLVIPRRTMHKGEGGHVLVLGGSQALSGAAVLTCLGALRAGAGLVTLACPADLARQIRCGWPEIMTIPLGEGFDWRREMFSQLKDELPRFDSVVVGPGMGRDDDTRAFFCDYLENVHQRTLFDADALYFLAGDDSLMQRISRSSEVILTPHPGEMARFFHVSAAQINQERSRFVREFSEKYNVNLVLKGASTLISGVDRHFYISPFATSNLAVGGSGDVLAGIIGSLMAQSLSTLDAASLGVYWHGLAGKDLENTYPFRGNLAREIADILPGVLARYKGKKVGDRVFFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQW4</accession>
    <name>D6SQW4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Siroheme decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ahb/Nir family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2535"/>
    <dbReference type="EnsemblBacteria" id="EFI35140">
        <property type="protein sequence ID" value="EFI35140"/>
        <property type="gene ID" value="Dthio_PD2535"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg2" evidence="8">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="17046" checksum="98844110FA3DC305" modified="2010-08-10" version="1">MELSATDKKILDIIQTDFPIDPSPYATVGRMVGLTQAETLARVRSLKQKGVIRRIGGNFNSRQLGWHSTLCAAAVPEEKLQEFITEVNQHPGVTHNYLRRHRNNVWFTYIGPSKEKVQESLQQITAVTGIEILNLPARNMFKIKVDFPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQY1</accession>
    <name>D6SQY1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ORF">Dthio_PD2553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870471.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2553"/>
    <dbReference type="EnsemblBacteria" id="EFI35157">
        <property type="protein sequence ID" value="EFI35157"/>
        <property type="gene ID" value="Dthio_PD2553"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="11624" checksum="A5FE46DF862DF0D1" modified="2010-08-10" version="1">MMVLVSYDVSFEDPSGKKRLRRIAKVCENFGQRVQYSVFECVVDPVQWTAFRDRLLKEYDEEKDSLRFYFMGKNWQRRVEHHGVGEIYDPENDALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQY9</accession>
    <name>D6SQY9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870479.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2563"/>
    <dbReference type="EnsemblBacteria" id="EFI35165">
        <property type="protein sequence ID" value="EFI35165"/>
        <property type="gene ID" value="Dthio_PD2563"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="8175" checksum="0368E7FB0F8F9760" modified="2010-08-10" version="1">MQALKEDRHGLDSRLKVLAFEIESPRNLPSWAAGVRGVPTFIIFKDGQEVDRLVATGRDDIVARLSEWIKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR76</accession>
    <name>D6SR76_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">Dthio_PD0518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0518"/>
    <dbReference type="EnsemblBacteria" id="EFI33192">
        <property type="protein sequence ID" value="EFI33192"/>
        <property type="gene ID" value="Dthio_PD0518"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="280" mass="31183" checksum="987AFFF8211FDF19" modified="2010-08-10" version="1">MSIDKILLATKMESRGARNMAQEIMAWMEKRNCSSCMAAFPYEKDMEDLPWNTPDLILVLGGDGTMLSVVRTLLDWQVPFLGINLGKVGFLAEVSPLTWKEQLSMVLESGGRISRRMLLEYSIFRGGRKRDTGVAVNELVVSRGELARIISLDLESSQGALESIRADGLIVSTPTGSTAYCISAGGPLVHPEMQAMILTPVCVFLHDFKPMVMPASESILLRIGNSTQEAYLTVDGQTGFVLKPGDELRVKRYHVDLQLLMCRDEGFINKLRYKKFFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRB9</accession>
    <name>D6SRB9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase containing von Willebrand factor type A (VWA) domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870593.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0561"/>
    <dbReference type="EnsemblBacteria" id="EFI33235">
        <property type="protein sequence ID" value="EFI33235"/>
        <property type="gene ID" value="Dthio_PD0561"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2141484at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="577" mass="65635" checksum="A9BE46BE9A1554FB" modified="2010-08-10" version="1">MAQKQKKSQDEEIIDLTEVIEEGNPEMAPPPKDREQESDDDFDDDLKDLFDSLGSDDEQDDQDSDLDKEFEDLFKEHSEQETGSKEKAGEEESEADDFLEELMQETGGSSEKDADKTGSRQEDPDLEDLFGDEDFEQESAEKTQTEDEPPLEPEPSLKEDMPQESEKQAETDFEPEPEAPPAEPPEEDLEPAEKPEAESPADEPADQAAPARETGEVDKSAPSGVEHLAQQMENMEERMDKLQAQMDLAEEEFAGRVLQTLEEKGSQLGFIQEMIPGIVNQAVEKGEEKIQEKLDELKEGELQDILSRLALLEEKVAGIQLPDIQELQDKLEQKIDQKIQNALSEQKEGPEQDFEALKQELHQELENKIQESLPDTEDSAAKKNTEQLQQEMDSLRQNELQDLNSRMKNLEDQVGSLDTPDVESIKNELEQKINQALDAVNNPQQEQPDLSGLKEEVVQSVEGRIQELVSTWQNEKKSLAAELENALTFWGRMQEKLTELSQDIGELKDRERQPDPELQEKLDSLYQDSVSREDLRHLASQLRHELEEHVQKQVPAAAARVIRDEIMAMLQEDQEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRQ3</accession>
    <name>D6SRQ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system F domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870727.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0697"/>
    <dbReference type="EnsemblBacteria" id="EFI33369">
        <property type="protein sequence ID" value="EFI33369"/>
        <property type="gene ID" value="Dthio_PD0697"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="71"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="274"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="404" mass="44548" checksum="B5B8CEB44DFE2179" modified="2010-08-10" version="1">MPPFKYKAINDQGATVSGTIDAADPGEAQEKLVRQGLIPQQVSTSREVFGDLSGRINLFLARVRLTDLVIFTKQFRTLMKAGLPMGSLLDVLEEQTENLKLKRTAARMKKDIQEGGTLAEAFEKEPQIFSQLYCNMIRAGESSGRMVDVLDRLIYLMQHEHKVKSDIKSALRYPVIVVIALFAAFLFLLTFVIPQFVGIFEGAGIELPLPTRISLALYQWIVVYWPVSVGTVISLAAGLYIFLRTEKGQYVKDLVLLRIPVLGPVLLKAAMSRFASIFSILQASGVSVLNAMDVLTGTIGNKVISGEFQRIQAELRQGRGISGPLGQSRFFTPMVISMVATGEEAGNLDEMLSEVSIHYDDEVEYAVSRMSETLGPVLIAMLAGVVGFFALAIFLPMWDMVQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRR9</accession>
    <name>D6SRR9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0716</name>
        <name evidence="2" type="ORF">Dthio_PD0738</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870743.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33385">
        <property type="protein sequence ID" value="EFI33385"/>
        <property type="gene ID" value="Dthio_PD0716"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33406">
        <property type="protein sequence ID" value="EFI33406"/>
        <property type="gene ID" value="Dthio_PD0738"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HNQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1967165at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8540" checksum="383F65419FF467F3" modified="2010-08-10" version="1">METRRYEQVLSDIQALPLSEQLLLLEQTASLVRNKAASSSKARSIMELKGMGKDLWKKIDVDNYIAEERASWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRT0</accession>
    <name>D6SRT0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870753.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0727"/>
    <dbReference type="EnsemblBacteria" id="EFI33396">
        <property type="protein sequence ID" value="EFI33396"/>
        <property type="gene ID" value="Dthio_PD0727"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1909198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="20022" checksum="43BD1478659E9216" modified="2010-08-10" version="1">MSTEPFTQEQISFLKEHMSQWLAEQSLGKPPMVYEIELRERMVRVEEELRNQRELIQYIIEQMDKRFEQVDKRFQQVDKRFEQVDKRFEEMRQDMNARFEQVDRRFEEMRQDMNSRFEQVDKRFEQADQRFLALTKRMDRLLIWSFGTTVTVGALIVAILKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRW8</accession>
    <name>D6SRW8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870786.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0768"/>
    <dbReference type="EnsemblBacteria" id="EFI33434">
        <property type="protein sequence ID" value="EFI33434"/>
        <property type="gene ID" value="Dthio_PD0768"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="423" mass="49061" checksum="E4614375E7501E74" modified="2010-08-10" version="1">MNTTVIHRHALEDLRRDIHRPEVAFLIGPRQAGKTTLMQIIQKELKDAGENTVFLSLDYDQDRVFFDSQQHLLKKIELETGKSGFVFIDEIGRLDNAGIFLKGLQDMGLPYKFIVSGSGSVDLRAGIRESMLGRKRIYEISPLNLLEFVNFKTDYQYSERLSDFFALEHARSEDILLDYMNFGGYPRVVLESLAREKNREMDEIYQGYIIRDIAYLLKVEKIESYSRLIRTLADQAGQIINYSELSSTLGISLPTVKNYCWYAEETYILQRISPFYRNLRSEITKAPTVYFHDPGLRNFALGIFGNLHRPDDLGFVFQNLVYLILREKIRFTGASIHFWRTTAKTEIDFIVDTGREVIPIEVKFQNMDKPSVPRAFDSFISRYSPSCCLVVNKKLQTTIRRHGTEVRFVTIWDLLLEDLPINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRW9</accession>
    <name>D6SRW9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870787.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0769"/>
    <dbReference type="EnsemblBacteria" id="EFI33435">
        <property type="protein sequence ID" value="EFI33435"/>
        <property type="gene ID" value="Dthio_PD0769"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032NQ5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1978887at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="17"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="149" mass="17151" checksum="F8FBC78F67E94709" modified="2010-08-10" version="1">MSSSIENNTGSREEHLAVICRQFSISIMYAFGSRAKETLSWLRQEIQEMCASQSDLDIGVLPIPGFYPSPREKVELCIRLEDFFQVSRVDLVILPEAPPFLASRVIQGERLYAADEYQADEYDLYVLRRAGDLMPFHRERLRLLFGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS00</accession>
    <name>D6SS00_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870818.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0800"/>
    <dbReference type="EnsemblBacteria" id="EFI33466">
        <property type="protein sequence ID" value="EFI33466"/>
        <property type="gene ID" value="Dthio_PD0800"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1838235at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="38"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="245" mass="26275" checksum="42E223C6A24BAFE5" modified="2010-08-10" version="1">MQAFLTGMGWLTSTGPGRGMQEFASPGESLRAPSREQVLESPDERFGRMDAFSKIGLAAAAKSLEDAGLAGKVDKHPAGIAAATRFGCISTDVDFLGTVFDTQGRWPSPHLFTYTLPNCFLGETALRFGLTGPSYVLHRSSPFSLGGVKAALYDLNDGEAEMMLAGSCDLQPPGGIDPWLDSCRHDAAGAVFVVLEAELRSQSRPYALVRLESDSIRLGSKQVHTMDDLVLQCQVLENSLSTTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSD8</accession>
    <name>D6SSD8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0939"/>
    <dbReference type="EnsemblBacteria" id="EFI33604">
        <property type="protein sequence ID" value="EFI33604"/>
        <property type="gene ID" value="Dthio_PD0939"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="34156" checksum="44E968DAC5D29C4D" modified="2010-08-10" version="1">MSLEITAKKIIGLFFVCVALYLGLYTWNARTEVLDRLGAYTGLEFVGWVLKPGVRVHSMAQDFWERYVYLVDVHQENRELRRELDSLKLELAAKSEKAAFAERLEDLLEFTSPPGWSSSGLRVVAHNYGPLGVLESIIVDKGRLQGISSNMPVVAPEGVLGRTYKTGLNFSTVLLLSDPNSRIPVVSSRSRTPGIIAGQGQNKPLAVQYVHLNAPLQEGEYLVTSGTAGIYPKGLPVARVSRVERSEIRLFQLVEAEKLVSAMDREEVMVLDNITKLRTDYLDFDGIIRDFSGEDMLLDERGGYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSE0</accession>
    <name>D6SSE0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870956.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0941"/>
    <dbReference type="EnsemblBacteria" id="EFI33606">
        <property type="protein sequence ID" value="EFI33606"/>
        <property type="gene ID" value="Dthio_PD0941"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005911">
        <property type="entry name" value="YhcC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF1">
        <property type="entry name" value="PTHR11135:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01091">
        <property type="entry name" value="uncharacterized_CHP01210-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01212">
        <property type="entry name" value="TIGR01212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="14"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="320" mass="35921" checksum="4C20D00FE013A954" modified="2010-08-10" version="1">MDIYNTLSSHWRKKFNTRVQKIPLDAGFDCPNRDGTISDKGCIFCNPAGSGTGLYSSGMSLEQQYQYWRTKYLSRHPEALFAAYLQSFSNTYGPAFRIKNCLKELASLPGLEVLCTGTRPDCLDQEKMRILAGFQAKETWLEMGLQSSRPETLKRINRGHTPDDFAHACRMAHREGLKVCAHVIAGLPGENLEDFLETVDFINLLPVQGIKVHNIYVCKNTPLAGWWRQGLFTPLSREEYVNWAVAALSRLRPDIVVHRLTGDPSGDELLTPEWSRDKTTTINSIKKSMQSRDLKQGADCRLSADVASADALSTCASRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSL5</accession>
    <name>D6SSL5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871030.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1018"/>
    <dbReference type="EnsemblBacteria" id="EFI33681">
        <property type="protein sequence ID" value="EFI33681"/>
        <property type="gene ID" value="Dthio_PD1018"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10575" checksum="3C0F5341A24F81EE" modified="2010-08-10" version="1">MKPLGELKEEILKDPDVKREYDRLQDEFGFASMLIEARTKAGLTQTELARRMGMKQAGIARLESGRHNPSMKTLQKYAAATGHELSVRMLPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSX6</accession>
    <name>D6SSX6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">17 kDa surface antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871141.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1131"/>
    <dbReference type="EnsemblBacteria" id="EFI33792">
        <property type="protein sequence ID" value="EFI33792"/>
        <property type="gene ID" value="Dthio_PD1131"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1671945at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032635">
        <property type="entry name" value="Anti_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016364">
        <property type="entry name" value="Surface_antigen_Rickettsia"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16998">
        <property type="entry name" value="17kDa_Anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002721">
        <property type="entry name" value="Surface_antigen_Rickettsia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Rick_17kDa_Anti" evidence="4">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="17kDa_Anti_2" evidence="5">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="16191" checksum="4CDC53C819D7594E" modified="2010-08-10" version="1">MRYLVVLTLAAMLLAGCTTQKHTVGGAALGGIGGGVIGSQIGKGTGQTAAIIGGTLLGAALGGYVGSYMDRMDEMDRRNMNQTLETKPTGTTSQWHNPDTQTAYAVTPTETYQRDDGRYCREYTTEVQIGGETEKAYGTACRRDDGAWEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST04</accession>
    <name>D6ST04_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871169.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1159"/>
    <dbReference type="EnsemblBacteria" id="EFI33820">
        <property type="protein sequence ID" value="EFI33820"/>
        <property type="gene ID" value="Dthio_PD1159"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738475at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="141"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="251" mass="27943" checksum="D6A673306E042203" modified="2010-08-10" version="1">MRDGEFFNTQKPSVLNLGGDTDIFVQGEAADCFYVLLSGQADLLRGEQKVMQLGSGTVLGTETLFRPDKGYLYTARTRGEARVARHGYQEFLDQAMSGPRLLRRVLDTHIREIEELWLRMDAAFKENQDYYFPGGIKSCAPGEWVIREGDRDDAIYRIVSSDQGLEVVKQDKVLALLREPGDFFGEMAAILGEARTAGVRSVGESVLEVYPGDRLNQMIADYPGMSARIISNLAQRLASTSRELACDSQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST70</accession>
    <name>D6ST70_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.1.2" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871235.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1225"/>
    <dbReference type="EnsemblBacteria" id="EFI33886">
        <property type="protein sequence ID" value="EFI33886"/>
        <property type="gene ID" value="Dthio_PD1225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1812068at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="204" mass="21514" checksum="BD95B10E8B42DD30" modified="2010-08-10" version="1">MLPQEIEQKSMEIIASEAGGHSFSAGQWAVVSRMIHTSADFEYMQSIRFHPLAVESGVEAIKSGRTIVTDTNMVLAGLRKKDLAGMGCRAVCYMDDPDAARLAREKGTTRAEAAVDMALDDMQGGIYVVGNAPTALLRLILLIREGKARPGLVVGLPVGFVNAAESKAELAGLDIPFITNLGRKGGSNVAAAVVNSLVIMAGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST86</accession>
    <name>D6ST86_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliP</name>
        <name evidence="13" type="ORF">Dthio_PD1241</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1241"/>
    <dbReference type="EnsemblBacteria" id="EFI33902">
        <property type="protein sequence ID" value="EFI33902"/>
        <property type="gene ID" value="Dthio_PD1241"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="236" mass="26240" checksum="0CACE8BE677BDD40" modified="2010-08-10" version="1">MWPVLAQAQDPVLPSLSLQLSGEEAQPDNIAVALEILFLLTILSVAPAIVLTITCFTRIIIVFSFIRHAIGTQQMPPNQVLAALAIFLTVAIMAPIGSEINQTALQPYLNEEIGHEEALSRAEGPMREFMFKHTRERDLSVFYSITGMERPESREDVPTMLLIPAFMISELKTAFQIGFLIYIPFLILDMVVASILLSMGMMMLPPVMISMPFKVLLFIMVDGWNLLVGSLVNSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STC8</accession>
    <name>D6STC8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871293.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1283"/>
    <dbReference type="EnsemblBacteria" id="EFI33944">
        <property type="protein sequence ID" value="EFI33944"/>
        <property type="gene ID" value="Dthio_PD1283"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065826at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10651" checksum="8A2351EFEBF526B5" modified="2010-08-10" version="1">MTSRIDFQSEIETLPPDLQKEVWEFVQFVKRRHGLPSERPEPSSAATTSDSALFQALDEIGFVGCIESDEQLSKTYKTKVDFSKKYGKYHDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6STE2</accession>
    <name>D6STE2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871307.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1297"/>
    <dbReference type="EnsemblBacteria" id="EFI33958">
        <property type="protein sequence ID" value="EFI33958"/>
        <property type="gene ID" value="Dthio_PD1297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="360" mass="40622" checksum="45B9D2704FAE95F0" modified="2010-08-10" version="1">MAQIDAFFKMMHELGASDLHLSTGSQPIIRLHGELQRIKYKALENEELKKMLYEITPENKVKVFEETGDVDFSYEVPNVARYRVNFFWQRLGVAAVFREIPQKILSIEDLGLPGIMKRLAMLPKGLVLVTGPTGSGKSTTLAACIDYANKTRKDHILTIEDPIEFVHQPENCLINQREVGRDTQSFKSALRGALREDPDIILVGELRDLETIELALEASETGHLVFGTLHTISASKTIDRIIEVFPGEMQGQIRSSLSESLRAIIAQSLFKRIDKPGRVAALEILIATPAVRNLIRENKNFQINSVIETGKKFGMQTLDESIMKHLQQSRIDPEDAYNKAVNKAKFKDYLKDTPQDFTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STH6</accession>
    <name>D6STH6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian cell entry related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871341.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1331"/>
    <dbReference type="EnsemblBacteria" id="EFI33992">
        <property type="protein sequence ID" value="EFI33992"/>
        <property type="gene ID" value="Dthio_PD1331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="505" mass="56443" checksum="ADCFA66F426F0DF5" modified="2010-08-10" version="1">MAKTASVEIKVGIFVLIAIVLLGYLTTVLTRDRIITRDTYEIHAYFDNVTGLRTNSPVEIAGIDVGTVKDITLHENRARVTMAIRPDIDVHADSQATIRTRGVLGDKFVEVNPGSATEPTLEDGGVVSRGVQPTDLDQVMARIGDIADDISEVSRSVSNVFGGPEGEQDMREFFDNLREAAVHMNQIVQTNARGIEKIVANLQDFSGDLKTISETNKEGITHIVDNFSQASSQLNVSLEQLGEIMDTAQHGEGPVATLLEDRQMSEDMRRTAASLESLTRKLDEGEGTLGKLISEDDTGRKIDDALDGINEFLDRYDRFQTVVDFRSEYMASTGDMKSYLDLTLQPAEDRFYMLSLIDDPKGRTRTTETVERERVDGGQWTVTETEEEKTYKDRLKFSAQLAKRWNDFILRGGLIESTGGFGMDYFLWDERIKLYTDVFDLGADRPHVKSGANLYFLDNFYLTAGFDDYLSKHGDSSFFGGLGFYFTDEDLKYLMSSVPVPDGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6STM7</accession>
    <name>D6STM7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flg_bbr_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871392.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1382"/>
    <dbReference type="EnsemblBacteria" id="EFI34043">
        <property type="protein sequence ID" value="EFI34043"/>
        <property type="gene ID" value="Dthio_PD1382"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1870921at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bbr_C" evidence="2">
        <location>
            <begin position="66"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="124" mass="13578" checksum="91DAD94C6F5D6B74" modified="2010-08-10" version="1">MVDSISGMGAFQSFGLRQQASAHNVANVNTRGFEPSRVVLEEAPEHQGVRPLSVEKVRDQALEHAREMQEDEAARVQEQALRPSNTDLISELVVMQQNEAAYAASAAATRTQSDMLGHVMDMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6STM8</accession>
    <name>D6STM8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbon monoxide dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:21040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.4" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871393.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1383"/>
    <dbReference type="EnsemblBacteria" id="EFI34044">
        <property type="protein sequence ID" value="EFI34044"/>
        <property type="gene ID" value="Dthio_PD1383"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="136177at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018492">
        <property type="term" value="F:carbon-monoxide dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043885">
        <property type="term" value="F:carbon-monoxide dehydrogenase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01915">
        <property type="entry name" value="CODH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016101">
        <property type="entry name" value="CO_DH_a-bundle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010047">
        <property type="entry name" value="CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005023">
        <property type="entry name" value="CODH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01702">
        <property type="entry name" value="CO_DH_cata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0533">Nickel</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005023-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="624" mass="66750" checksum="3E80C12EBCACBE71" modified="2010-08-10" version="1">MPKKKKSIEEKTLWPDAARMLDKAEKDGVETAWDRLEQQTPHCKFCQTGLTCRNCTMGPCQIRKNAPLGVCGADADVIVARNFGRFVAGGSAGHSDHGRDCIEALHSVALGKSTDYSIKDEAKLLRIARELGIAVEGKGVSEVALELSDLFFADFGSRQHEVSFLVRVPEKRKKLWNELGITPRGVDREIAEMMHRTHMGCDNDAPNLMLHSARTCLADGWAGSMIATEISDILFGTPKPGKSKVNLGVIQEDMVNILVHGHNPIVSEKVLEAVNDPEMISLAREKGAKGINLAGLCCTGNELMMRQGIPLAGNHLMTELAIVTGAVELIVVDYQCIMPSLVTAGNCYHTKMVTTADKARFTGAEHVPFDMHNASHQARKLVQTAVEGFSRRDSSRVEIPQGPMEMITGFSNEAILEALGGTPGPLIEAIKAGKIRGAAAIVGCNNPKYRQDYGNVNLAKELIKRDILVLVTGCVTSAVGKAGLLMPEAADEAGAGLHEICKALGVPPVLHMGSCVDNARILQLAGILANELGVDISDLPLAGSSPEWYSEKAAAIGTYCVASGIFTHLGHPPNITGSETVTNLALSGLESLVGASFGIEPDPFKAAEMIDERITSKRKGLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6STM9</accession>
    <name>D6STM9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34045">
        <property type="protein sequence ID" value="EFI34045"/>
        <property type="gene ID" value="Dthio_PD1384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="43" mass="4910" checksum="1787AB16FA50ACC3" modified="2010-08-10" version="1">MVTEDDSPCREWIHFDHKLLSVKFACLQKGVTIQGMPGEFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STP6</accession>
    <name>D6STP6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphonate ABC transporter, periplasmic phosphonate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871411.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1401"/>
    <dbReference type="EnsemblBacteria" id="EFI34062">
        <property type="protein sequence ID" value="EFI34062"/>
        <property type="gene ID" value="Dthio_PD1401"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="988224at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088074" evidence="1">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="307" mass="34750" checksum="6010F41FE756B580" modified="2010-08-10" version="1">MHKKSVLCLMLLVLSLGFLFSCGEDETPVKVSLEKREEISIRPQAAALTYAYLPQYSHTESFQRHNRLVEYLSQETGLSIRQVFPDTFDDHINKFGQGKIDISFSNPFVYAKLAGRFGGEAFTRIIEEDGRAEFRGKIIARRDNQEIQTLEDCKGTSWVAVDPSSAGGYLFVLGHFVEHEITLDDFAEVVFAGGRQENVILGVYSGLHDIGAIREGSLSVVEDKIDTRQIKVIDHSRWYPGWVYAHSPRLTDETVAKIKEAMLKLDYDDPEHRDILEAARFKGFVPSSDEDFDPIRDLSKKVGLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6STQ3</accession>
    <name>D6STQ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1408"/>
    <dbReference type="EnsemblBacteria" id="EFI34069">
        <property type="protein sequence ID" value="EFI34069"/>
        <property type="gene ID" value="Dthio_PD1408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="10176" checksum="7D96F1D6C22DE94F" modified="2010-08-10" version="1">MKKHRARKHPDHKPPVTIQWVPVITSESRRQAYSPTVCGEAARVQPTAASAKKSSPAREAYRLHTRLKYALLSYGILAGRQVLRTHGFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6STZ5</accession>
    <name>D6STZ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871508.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1504"/>
    <dbReference type="EnsemblBacteria" id="EFI34161">
        <property type="protein sequence ID" value="EFI34161"/>
        <property type="gene ID" value="Dthio_PD1504"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="14704" checksum="7710653FFC3A3324" modified="2010-08-10" version="1">MGYKYFEELPCWQVARELCQEVQQIIHQERFRRDFSLKDQISRSSGSIMDNIAEGFDDGSSREFVRFLGYSQRSCGEVQSQLYRAWDCQYLNRDQFSRVYHLAGECRKQIKGFRRYLRENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUA1</accession>
    <name>D6SUA1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871574.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0195"/>
    <dbReference type="ESTHER" id="9delt-d6sua1">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32881">
        <property type="protein sequence ID" value="EFI32881"/>
        <property type="gene ID" value="Dthio_PD0195"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="61"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="326" mass="37028" checksum="AF52DA6935B72327" modified="2010-08-10" version="1">MPVLPSPGYTPVHLFRNGHVHTVYPALFRPVPHTDPDRERIDTPDGDFLDIDWHMSRRSDKRTAVVISHGLEGNSRKKYPLGMARHLTRLGMDAVCMNFRGCSGTPNRLPRLYHSGVTDDLDTVIHHVIRQGYENVFLVGFSMGGNQLLKYLGEDPGQVPCQVRAACSFSVPCDLSASSARLDSTVSRIYVMHFMRSLRAKIRLKAKMFPGIFDAKGLNITWSFHDFDNRYTAPLNGFRDAEDYYARASCLQFLKNIRVPSLLVQAGDDPFLTPSCFPLEQASKNDHLFLEIPEYGGHVGFHLPNRENIYWSEYRAGEFLLEKKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUS6</accession>
    <name>D6SUS6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871749.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0370"/>
    <dbReference type="EnsemblBacteria" id="EFI33056">
        <property type="protein sequence ID" value="EFI33056"/>
        <property type="gene ID" value="Dthio_PD0370"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2185914at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="145" mass="16533" checksum="6A430314F04FA21C" modified="2010-08-10" version="1">MSLKNFGGVLDYAIAMEKQDGGFIQQAMNNPDMQDCSELLQALAKENLKNAKNLARARQENISEMILEPVQGLEEKSYQLSQPDAEGISRPEIMQLLQRMEERAQQFYTDAAEKIRPVSDVFSTFQKLAKKRKARIEKLNPVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUW7</accession>
    <name>D6SUW7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871822.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32723">
        <property type="protein sequence ID" value="EFI32723"/>
        <property type="gene ID" value="Dthio_PD0006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088209" evidence="1">
        <location>
            <begin position="37"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="23672" checksum="AEAC08A84E2E9EA6" modified="2010-08-10" version="1">MTKRSKALCNKAYLVPTLPVFMAILAVMLSTTVANAQRAPEDLLNQNTYTEESYSIETYNFAETGGNAYFMLQVKNPRYEHFQLEFDMSHSIISMLPASEIMPGSKDKAAWELIKDGGVLVAEEVLPPVLSAAEIMDEFFEELDRRRDVEADNFELRNIPQGDSVMYFVWTSGDDPLNVWYSAEYARSGEETISRSRGTVPMSADRKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV10</accession>
    <name>D6SV10_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32766">
        <property type="protein sequence ID" value="EFI32766"/>
        <property type="gene ID" value="Dthio_PD0057"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="16442" checksum="833E148CF7685AB7" modified="2010-08-10" version="1">MEVMQFLNRTTLELDTKIHEIYDLLEKLPDNDKLTDYLFIIVRYVMASGAIPEKRLLEHTKRFSGGEEMIGVAAREIREDVLQKEKPYWEKHAKLEYARENLIDVATEAYGPLPDMLHEKIKSIQSLENLRALNRKVIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJW6</accession>
    <name>D6SJW6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3625"/>
    <dbReference type="EnsemblBacteria" id="EFI36169">
        <property type="protein sequence ID" value="EFI36169"/>
        <property type="gene ID" value="Dthio_PD3625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="9033" checksum="C82C904B51DF4845" modified="2010-08-10" version="1">MKFSDVVTEAGQYKVTVTGPDHRGFIRFVNSKDQVMSWMVRTDGRVWKGFTRQPSTTRIKKGSKAFVADWCLDWAANGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJX1</accession>
    <name>D6SJX1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869296.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3630"/>
    <dbReference type="EnsemblBacteria" id="EFI36174">
        <property type="protein sequence ID" value="EFI36174"/>
        <property type="gene ID" value="Dthio_PD3630"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZPW6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8980" checksum="59AADFEF96CC6703" modified="2010-08-10" version="1">MQMFGRDVSDMNIHEINKLFRQYDESHKWPVCNQFNATDRAIGRLRRNVLPHVGPTGGIEYAYMLDEEISQIVNSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJX8</accession>
    <name>D6SJX8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869303.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3637"/>
    <dbReference type="EnsemblBacteria" id="EFI36181">
        <property type="protein sequence ID" value="EFI36181"/>
        <property type="gene ID" value="Dthio_PD3637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8515" checksum="95F25CC77351BB70" modified="2010-08-10" version="1">MQCVRCNRQLRLQDFVLLEENESDPHDSLVMGLCECSEMMVLSEELEHEYWQQRILHAQMERSRELHHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJY6</accession>
    <name>D6SJY6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869311.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3645"/>
    <dbReference type="EnsemblBacteria" id="EFI36189">
        <property type="protein sequence ID" value="EFI36189"/>
        <property type="gene ID" value="Dthio_PD3645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="246" mass="29105" checksum="7F56BCEAD994933B" modified="2010-08-10" version="1">MNDPQNMPATKDLKVGFYFYWKWQYQLRNDYLHNDNETEQAIDINSYLDIVDQDKSYVKKSEEIIRSWLNGDIRLDSLLTCVPRFYRSGYHFVESYYKDNVLSLSISIDTSNFDIKKIKKNITNELDGIFQLIEDEQNGDGIVPERILCIGHEHYWRGAALKEVKDLRLDFLARAVGLWIWDQKNKSPDKSPDKSISQLMDELADLFPDIVEIDEGKPDAWHLESKWYKRYYTTDKCIKKIEVINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK04</accession>
    <name>D6SK04_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4168 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869329.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36207">
        <property type="protein sequence ID" value="EFI36207"/>
        <property type="gene ID" value="Dthio_PD3664"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031CUR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025433">
        <property type="entry name" value="DUF4168"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13767">
        <property type="entry name" value="DUF4168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4168" evidence="1">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="99" mass="11259" checksum="4F2DA53FB112B0B2" modified="2010-08-10" version="1">MQDSKNFMGSDIGESEMDKVAEAYKSIKSIKENVHKEMTALNDSDETLQKLEKAGEDMVRAVEQQGLDFETYNEAMEAVKTDDELRRSLNKRLQSSGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK29</accession>
    <name>D6SK29_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869354.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3689"/>
    <dbReference type="EnsemblBacteria" id="EFI36232">
        <property type="protein sequence ID" value="EFI36232"/>
        <property type="gene ID" value="Dthio_PD3689"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879806at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14670" checksum="8C7BDC6C470B1A3D" modified="2010-08-10" version="1">MKHEDLTRKIIACAYNVHNKLGFGFLESVYRRAMMIELARMGLKAEEEKPLKVHYDEHIVGDFSADILVEDEVIVELKSVQQFAIGHELQLVNYLNGIKLDVGLLLNFGPRNVDVKRKYRKKEIEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK54</accession>
    <name>D6SK54_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1770</name>
        <name evidence="4" type="ORF">Dthio_PD3717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869376.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1770"/>
    <dbReference type="EnsemblBacteria" id="EFI34412">
        <property type="protein sequence ID" value="EFI34412"/>
        <property type="gene ID" value="Dthio_PD1770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36257">
        <property type="protein sequence ID" value="EFI36257"/>
        <property type="gene ID" value="Dthio_PD3717"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1363223at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="205"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="378" mass="43294" checksum="6D9A9C99F7878DB5" modified="2010-08-10" version="1">MSKKTKLPKLVLTPEQRIKLETISNARAASLRDVQRAKVLLLYADGKPITHIQKQAGLSRPSIYKCIEKALAAGPEAGLKDYYHRPFDPVIDDAAKAWVVNLACTKPKDYGFAAELWTYQELARYTREHAPKEGHHCLANAAKATIWRILNEHDIKPHKIKYYLEKRDPDFEQKMNDVLVVYQEVNMQNDQGDIAVPSKTITVSVDEKPGVQALETIAPDLSPAPGRHQCTGRDYEYKRHGTVSILAGLDLHTGEIIAQVHDRHRSREFIELLKEIDSRYPKENTIRLVLDNHSSHISKETMKYLASLPNRFEYVHTPKHGSWLNLIESAFSKMARTFLRHIRVSSKEELKERILKGIAEMNSAPVIFRWKKFDLECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK84</accession>
    <name>D6SK84_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869406.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3750"/>
    <dbReference type="EnsemblBacteria" id="EFI36287">
        <property type="protein sequence ID" value="EFI36287"/>
        <property type="gene ID" value="Dthio_PD3750"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="13"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="511" mass="56680" checksum="C0BEA41B503D2792" modified="2010-08-10" version="1">MDQAQTQKVLVLGASGYVGGRLVPLLLEKGFQVRAAARNTDKLSCRDYASHPGFEPFRVDVMDQDSLDKACQGCRAAFYLVHSMGPDKDKKSDFESKDRQAARNMVAASEKAGLKQIIYLGGLGEDDEDLSHHLKSRLEVGRILQDSSVPLTFLKAAMILGSGSASFEIMRYLVERLPVMITPTWVHTDCQPIAITNVLGYLAGSLDNPDAMGKSFDIGGPDILSYAKLFQIYAGEAGLAPRLIIPVPVLSPRLSSYWIHLVTPVPASIAAPLAQGLKNTVVCRENTIREVIPQELVSCREAIKRALEHSGRDRDSTCWRDAGEISVPEWTTCSDSRYAGGSIYEIAYQVHLGAPPEKVWPVIEGIGGENGWYYANSLWRLRGLADKIMGGSGYRKGRRSREELRFGDTVDFWKVIQVQKNEHLKLLAEMKMPGEATLEFELQPEGTSRSILVQRTRFYPRGLPGIAYWKSLVPFHNQLFKGMLRGISRKTGARIIKGPIRAGKKDSCRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK94</accession>
    <name>D6SK94_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0173 metal-dependent hydrolase Dthio_PD3760</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0173 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869416.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3760"/>
    <dbReference type="EnsemblBacteria" id="EFI36297">
        <property type="protein sequence ID" value="EFI36297"/>
        <property type="gene ID" value="Dthio_PD3760"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00457">
        <property type="entry name" value="UPF0173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022877">
        <property type="entry name" value="UPF0173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="9"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="231" mass="24436" checksum="F4481BA5703F89FA" modified="2010-08-10" version="1">MSSKLIWHGHANFEIVTSGLNILIDPWFEGNPSAGSASGDVKKADLVLVTHDHADHIGQAVDICQKTGAYLGAIVEVAGKCKSMGVDPGKIVNGIGFNIGGTIDFEGVQVTMTQADHSADQGSCVGFIVTLPGGGPCLYHAGDTGIFATMQLWGELYDIDVAILPIGGVFTMDPRQAALACRLLGCKKTVPMHWGSFPVLEQNTENYKKELQARAPGTELLAMQPGESIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKB2</accession>
    <name>D6SKB2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869434.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3779"/>
    <dbReference type="EnsemblBacteria" id="EFI36315">
        <property type="protein sequence ID" value="EFI36315"/>
        <property type="gene ID" value="Dthio_PD3779"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="301" mass="34812" checksum="F12CF3D9EBDCFDC6" modified="2010-08-10" version="1">METMPAGNEQRVFRARYKIDTPGLISHITQRAAGKEPLFLDDRDYLTMLGLFKESSEKFSLDYYALCLMPNHTHALLKPKERNLAVAMRSIFSRYAAKFNRRYERRGHLFGGRYRQSVCLDDTYLLTASVYIHLNPVRAGLVDDALQYRWTSSALYCQDNPKESFIDPGPILELVDDDGQKARRKYRRILKKARGEEPENALEHQGAIERFCIRLSEIFPGLFKRLGGKKDAGQDHTPSLLELTELEQRLQDLGNARARNEESKMVRKYIVEQLIARGYKKTEIAEKLGISLRNVYYILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKE1</accession>
    <name>D6SKE1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869463.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3812"/>
    <dbReference type="EnsemblBacteria" id="EFI36344">
        <property type="protein sequence ID" value="EFI36344"/>
        <property type="gene ID" value="Dthio_PD3812"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="374" mass="40677" checksum="84F27A41EC017556" modified="2010-08-10" version="1">MGLKNSLQRVYICSAAYDDRLDEVVEKILEVFPRERKDRLILVKPNILGPHAPEKAVTTHPMLVKSVVRVLEKKGARVIVGDNPGMGGYGKALHSARKCGVLECAGQCFVNLGHNPVRKDIHSKYFSQATISREVLEADEVINLPKLKTHSLTVLTGAVKNTFGYVVGADKMYLHASCPSAADFARGLLDIYQVRPPELNIMDAVLAMQGNGPSNGTPVYLNRILASDNAVSLDAAATHMLGIRPSQVPHLDFAGKMGLGETDPEKMNIKGSLEKIPGFKFPGTFIPGITGLVLNRYLSRWANCLPEVVSSRCISCGICAGHCPVGAMSMSSSGPVLDRDKCINCYCCQEMCPEDAIRLSGRFLRLLGRGSRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKJ4</accession>
    <name>D6SKJ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2613"/>
    <dbReference type="EnsemblBacteria" id="EFI35205">
        <property type="protein sequence ID" value="EFI35205"/>
        <property type="gene ID" value="Dthio_PD2613"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031B2K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="137" mass="15757" checksum="C867A25EE0F18573" modified="2010-08-10" version="1">MGTGSSGTHLSQKMRYFKHKMMLKWVPECLSPAFLKSAKQIQQIVEKDQHRFTLHALERMIERKIQPAAIKETILNGEIIEFYPEDKYGPSCLIMGSSGLDTFHVLCSLNPVWIITAYNPAFYSEKCDKSFKKRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKU6</accession>
    <name>D6SKU6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2722"/>
    <dbReference type="EnsemblBacteria" id="EFI35307">
        <property type="protein sequence ID" value="EFI35307"/>
        <property type="gene ID" value="Dthio_PD2722"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="315" mass="35373" checksum="655BC8AAE8E4BAC7" modified="2010-08-10" version="1">MKKDLKDIMLEGKSKTPLKVSVIIPVYNDSYRLEACLRALSVQSYPKHLYEVVVVDNGSNDLPEKVADCYKGVILTKEERPGSYQARNRGIHLAQGEILAFTDSDCIPDKDWISAGVACLVEAEKTGIVGGSIQFFFNDNLNPSVPELYDSITYLQQKDAITLKKFAATANMFTWKEVMRHAGLFDVTLKSGGDREWGQRASALGYYLAYAPEAVVLHPARKSFSQIYKRNIRINGGHHQLRKRLREGKSDITVLLSELARDLCPPVRFGFRIINDERVPGLRNKLLVTCFHMLIKMGNAGARVSHQMGREPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKX5</accession>
    <name>D6SKX5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dxs</name>
        <name evidence="12" type="ORF">Dthio_PD2751</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868468.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2751"/>
    <dbReference type="EnsemblBacteria" id="EFI35336">
        <property type="protein sequence ID" value="EFI35336"/>
        <property type="gene ID" value="Dthio_PD2751"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="630" mass="68488" checksum="2967FE1DA8F42118" modified="2010-08-10" version="1">MTSQEEPILAGLASPEDIRGLSLTQLNRLAREVRELIISVVSTNGGHLAPSLGTVELTLALLKVFDPSKDKIIWDVGHQAYAYKILTGRRDSFHTLRARGGISGFPRPVESSFDHFAVGHSSTSISAGLGMAVAGDILDKDQKVLSIIGDGSMTAGLAFEGLNQAGDLDRDLVVVLNDNEMSIAKNVGALSSFLSSNLSSRWMVRFKKDFESFMRQIPRIGDDILNYARKSEESLKNFFTPGILFEALKFNYIGPVDGHNITSLSRILEQTKTLQGPVLVHVMTRKGKGYKPAEENPTFYHGVGCFEPETGLARKKPDGECLPSYTDVFGRTLCELGEKDDSIVAITAAMPEGTGLGAFAERFPERFFDVGICEQHAVTFAAGMATQGLKPVVAIYSTFLQRSYDQVVHDVCLQNLPVTFCLDRGGIVGEDGPTHHGNFDFSYLRHIPNMICMAPKDEAELQRMLATALVHPGPVSVRYPRGVGTGADLGETAPLDMGSSEVMKEGTHGVILAIGSRVYPALEAALEMEKDGLSLRVVNARFVKPLPLQELREAAANYKGLLVVEENALAGGFGSAVLEFLADEDLLQGVRVKRLGIGDFFVEHGPPQELRQNLGLCKNGIKKAAMEFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKY3</accession>
    <name>D6SKY3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent 7-cyano-7-deazaguanine reductase</fullName>
            <ecNumber evidence="1">1.7.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADPH-dependent nitrile oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queF</name>
        <name evidence="2" type="ORF">Dthio_PD2759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:13409"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="EC" id="1.7.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.13" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868476.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2759"/>
    <dbReference type="EnsemblBacteria" id="EFI35344">
        <property type="protein sequence ID" value="EFI35344"/>
        <property type="gene ID" value="Dthio_PD2759"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0780">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1675155at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046857">
        <property type="term" value="F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033739">
        <property type="term" value="F:preQ1 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00818">
        <property type="entry name" value="QueF_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029500">
        <property type="entry name" value="QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016856">
        <property type="entry name" value="QueF_type1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14489">
        <property type="entry name" value="QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027377">
        <property type="entry name" value="Nitrile_oxidored_QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03139">
        <property type="entry name" value="QueF-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimide intermediate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="15975" checksum="D6DCCD42A4D8F419" modified="2010-08-10" version="1">MRDDTSGLTLLGKTRPEYPSRVDPGVLETFANKFAERDYEVVMVTDEFTSLCPVTGQPDYGTIELRYVPGKECIESKSLKYYLFSYRQEPTFMETVVNRILDDLVQACSPRQMKVVGRFKARGGIAIDVSAQYRREDQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL30</accession>
    <name>D6SL30_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868523.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2807"/>
    <dbReference type="EnsemblBacteria" id="EFI35391">
        <property type="protein sequence ID" value="EFI35391"/>
        <property type="gene ID" value="Dthio_PD2807"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="278" mass="30630" checksum="A5AD00D3DDA76CD0" modified="2010-08-10" version="1">MVRWSVRGGGVIGPAPFLIAGVVNITPDSFYDGGRHYSLEAAAHHGLELLSQGAHILDLGGESTRPFSERVEADTEMDRVMPVLQKILKARPEATISVDTYKASVAARCLEAGACIINDISACRFDPQLLDVLVQYKPGYVLMHTLDRPESMQTDPRYRDVTREILSFFETHLARLVQAGIPESHIVLDPGIGFGKNLEHNLEIMRNMECFHILGRPLYVGLSYKSLWSGLLEVELEGRGMPTQVGTALMAAKQVGIHRVHDVADTANTLKIVENICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL49</accession>
    <name>D6SL49_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868542.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35410">
        <property type="protein sequence ID" value="EFI35410"/>
        <property type="gene ID" value="Dthio_PD2826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="83" mass="9609" checksum="DD0652FF540A06A5" modified="2010-08-10" version="1">MTLSVRLDENTRHKLQKTAEALRVTRTEVVRRSLQEYCERTLKEIEQSPYELIKDLAGSAASGQGDLSTRGEEIMRRRFGRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLG6</accession>
    <name>D6SLG6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2951"/>
    <dbReference type="EnsemblBacteria" id="EFI35527">
        <property type="protein sequence ID" value="EFI35527"/>
        <property type="gene ID" value="Dthio_PD2951"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="77"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="448" mass="50070" checksum="4FCB6089D161DCC1" modified="2010-08-10" version="1">MYHPQNRISTRSMKRRDFLWLASVSTLGLVSGCAVNPVTGERQFMLMSESGEISLDQKHSPHQFSADYGEVQDSNLNSYLDRKGKDLAAITHRPDMPYSFRCVNATNVNAYAFPGGSIATTRGILLEMENEAELDALLGHEIAHVNARHTAARMSRAIMAQALLAGASLYLESQQEDYAAVAAGLGAVATGALLASYSRANEREADELGMQYMTDAGMNPQGMVGLMDVLQGVNSRKPSAIERMFSTHPMSQERYDTARYRAENEYAHARDFPVHRERYMDNTADLRRMRGAIEDMQEGEEHMGRQRFHEAEDSFSRALSQAPEDYAALVLMSKCQLALNRPQRARNFSDRAVRVYPQEAQAHHISGVAAMDLGRYDAALEGFRRYEDMLPGNPNTIFLKAVCLEGMGRKSDSAGEYERFLHSSGAGEKADYARKRLQEWGYMDSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLI2</accession>
    <name>D6SLI2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868675.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2967"/>
    <dbReference type="EnsemblBacteria" id="EFI35543">
        <property type="protein sequence ID" value="EFI35543"/>
        <property type="gene ID" value="Dthio_PD2967"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1513561at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="366"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="431" mass="47603" checksum="FFE62ECF3A237A37" modified="2010-08-10" version="1">MNIPAFIMFAGFIFWLLAFPMDGILLTEEGGRPLILYFLFPHIAALYLLSFFLRKRLRFLADAGVILAGITTLAFPFHPEYAHVLLFLCGPAAAPVMIRMGVLLKAEPNFLKHIFLGLILGNLLTIGVTIAPAGYWAYVLTAICLGLSLGRPTIILDAPLKKILLHQPLIFVLYTLAGLMYGFLAPGYFAGDPLPGMEIFFYMAAIFLAWYFFSRELNSLIYIAVALAILSQPALYDLNPLFFTSGIFSMQASMGFADFFVLALAISHCDPARGIGINSATLCLGIAAGVMVSMTHLEMVTMVAVMGNVALALSIVLLMVIRRKKSAQEHETSSVQVFQDPLYTPESTETAEEIPELETRKEVQLPAKVTGMLSQREKEVLEKVLVNGRLYRDAAQEMGISESTVKTYMKRIYIKTGVKSRKDLDELCGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLM3</accession>
    <name>D6SLM3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868713.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3010"/>
    <dbReference type="EnsemblBacteria" id="EFI35584">
        <property type="protein sequence ID" value="EFI35584"/>
        <property type="gene ID" value="Dthio_PD3010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="118"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="338" mass="39629" checksum="7614A425AAD98E32" modified="2010-08-10" version="1">MNLGSCLHTFFDQYLPRTKGVSSNTILAYRHTFSLFLPFASKTLGRDINSLEIGHLSTQLILDFLDHLESGRNNSARTRGHRLAVFKSLARMIRFLYPEHKLLADRIISIPQKRFPKKLAAFLTHEEVLLVLDSINLKKSGAFRDYTIIHLLYNSGARAEESASLRLDYFDPHKKTLAILGKGNRYRQIELWPKTVQLMSMYIQKYRPRPKPLHQNTLFLNQRRQGFTRNGIYRLCRKYLSLVFEENRFQGLNPVHCFRHSCAINMLGTGFSLTDIKNHLGHENLQSTMVYLKLSLNRKRELQQKFIEYTQNQTQDPKLDELLDWEKEQETLDWLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLM8</accession>
    <name>D6SLM8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868718.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3017"/>
    <dbReference type="EnsemblBacteria" id="EFI35589">
        <property type="protein sequence ID" value="EFI35589"/>
        <property type="gene ID" value="Dthio_PD3017"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="11648" checksum="4C3628E71D21C3A7" modified="2010-08-10" version="1">MKVVNIFEEGTFSDKAMKKNLVHDSPYFRIINFNFRAGQELPIHSHELEGELSIQVLEGEGEYLAKDRTLPARAGDILVCAIEESHGIRAVTDMRVLVTIAPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLN7</accession>
    <name>D6SLN7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Filamentation induced by cAMP protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3026"/>
    <dbReference type="EnsemblBacteria" id="EFI35598">
        <property type="protein sequence ID" value="EFI35598"/>
        <property type="gene ID" value="Dthio_PD3026"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="323"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="414"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="596" mass="68024" checksum="6009EBF45C32946E" modified="2010-08-10" version="1">MAKILIVDDVPANIKVPCRLLKEYHQLMVASNGEKASFISTGITTRVKSRILLTHKGYWLKIKFQNYIYKGIFFMARNQFSGPATFFQDRRLPVKATPAGYSALIDYFDLRVPLPRTLFAIGDRHRTIQEQGWHILTPRHTPSPDIQSHLKFAIKYEGLDLAVLKRLFQATGPKPIEAMVKSRPTGSYARRSWFLYEWLLGEELNLPDARTGRYVSVVDPNMQFAMQGKGSPRHRVRNNLPGTSAFCPMVFCTQVLQEFMDQKLKQKTLEIIDDVPRDILARSSVFLLLKDSKASYAIEGEGPSHDRVQRWARAIGEAGQNDLDQDELVRLQKIVIGDSRFVDLGLRTGEGFVGEHDRNTGEPIPVHISAKADDLPELVQGLIEFEHSSGLELDPVVAAAVLAFGFVYIHPFEDGNGRLHRYLMHHVLSSRGFNPPGLVFPVSAVILERIEEYRKVLEDYSARLMPAIEWKPTDKGNVQVLNDTADFYRYFDATPHAEFLYDCVRRTIEKDLPEEALFLRRYDQFKARVQSLVDMPENTLNLLFRFLRQNQGKLSKRARSKEFNALTDDEVQSIEEIFQENAGNASPTLKRRAQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLT3</accession>
    <name>D6SLT3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868773.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35644">
        <property type="protein sequence ID" value="EFI35644"/>
        <property type="gene ID" value="Dthio_PD3073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="75" mass="8690" checksum="6AF4DC198ED76AA6" modified="2010-08-10" version="1">MFFSRKQEGFSFLGFVVVLALIAFLLMIAIPQYLEYRDRDQDNTGLLDDPVKISQAWDKEISNNNLYVVLSSTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM37</accession>
    <name>D6SM37_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868877.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3177"/>
    <dbReference type="EnsemblBacteria" id="EFI35748">
        <property type="protein sequence ID" value="EFI35748"/>
        <property type="gene ID" value="Dthio_PD3177"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="11441" checksum="A3D7DDBA61CAD1B1" modified="2010-08-10" version="1">MIRSIQDKETKRVWNGQGSTRLPQDIQRIARRKLRMINNAQNINDLRIPPGNRLEKLKGKKHHQYSIRINDQWRICFEWGEGDAYNVEIIDYHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM82</accession>
    <name>D6SM82_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868922.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3228"/>
    <dbReference type="EnsemblBacteria" id="EFI35793">
        <property type="protein sequence ID" value="EFI35793"/>
        <property type="gene ID" value="Dthio_PD3228"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="151" mass="17243" checksum="F8FBA48206B5C08D" modified="2010-08-10" version="1">MIDAQMLKKQILLQDMDEYELGKIAKIVEKVSIKQGEVLFQEEDDTRGLWLIHSGKIQISKMAADGWRQTLVVLGEGHFFGELAIVEKRKHVSKAEAMEDTELFLIPKESFEELVADDCALAMDFFKSMVVALSSNLRRMNDKFLSVLISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMC7</accession>
    <name>D6SMC7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3275"/>
    <dbReference type="EnsemblBacteria" id="EFI35838">
        <property type="protein sequence ID" value="EFI35838"/>
        <property type="gene ID" value="Dthio_PD3275"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="51"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="274" mass="30939" checksum="B710EF660C527638" modified="2010-08-10" version="1">MLNQTGNFACPGQGNGSRFLFIRRGQETQKITTETDRLKARIEQRDRFFSILAHDLKAPLAGFLSFLRMMVEDIDSFTREELQVALKDMQECAENQYMLLENILQWSLMQRGELSFMPERILLSDLLKNNASLASGPARQKGIKVESRVVHEIEIVADKNMLQAVFRNLVFNALKFTPENGLIQMSCRQHNGVAEVVVRDNGIGMDQKTLSGLFRPEKKTRRNGTNGEKGTGLGMVLSREFVSMHKGRIWAESSPGQGSVFYVQLPVIFHETAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMH9</accession>
    <name>D6SMH9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3329</name>
        <name evidence="2" type="ORF">Dthio_PD3336</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3329"/>
    <dbReference type="EnsemblBacteria" id="EFI35890">
        <property type="protein sequence ID" value="EFI35890"/>
        <property type="gene ID" value="Dthio_PD3329"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35897">
        <property type="protein sequence ID" value="EFI35897"/>
        <property type="gene ID" value="Dthio_PD3336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="48" mass="5257" checksum="36E5750DFF362BF1" modified="2010-08-10" version="1">MDKEKNHFVLAGSQAKRLSLQHSLFSGSHESQKKVSAGWLMQSAASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMP8</accession>
    <name>D6SMP8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869087.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3401"/>
    <dbReference type="EnsemblBacteria" id="EFI35959">
        <property type="protein sequence ID" value="EFI35959"/>
        <property type="gene ID" value="Dthio_PD3401"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02038">
        <property type="entry name" value="FlhG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033875">
        <property type="entry name" value="FlhG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="273" mass="30429" checksum="31CE34FA12C62FDA" modified="2010-08-10" version="1">MPKQTKLPIVLSLTSGKGGVGKTNMSVNLAYCLSRLGKKTLLLDADLGLANVDVILGLNPRFNLFHLFHENMDLQKIILPTDYGFDILPSASGVTEMLSLSTGQKLELLEVMDTLENELDYLIVDTGAGINENVIYFNLAVQERIIILTPEPTSLTDAYALIKVLKIQHGIERFRVVVNMAKSQEEAREVFKKLYNACDHFLSGISLDLSGIVPMDLNVRKGVASQQPFCHYAPNSKASKALMHTAESMTKWKPAENLDGNIKFFWKKLLFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMS4</accession>
    <name>D6SMS4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease M5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869113.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35985">
        <property type="protein sequence ID" value="EFI35985"/>
        <property type="gene ID" value="Dthio_PD3427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="83" mass="9487" checksum="11CCC0A5A5041844" modified="2010-08-10" version="1">MLVPSYFQISPKSRHEIQTQLQKAGREIRIDSDDRREGLGQKQKSEYGRKKREKSAVSGIGKTYAEVHEVYNKKAEIVRVAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMV2</accession>
    <name>D6SMV2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="8" type="ORF">Dthio_PD3455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869141.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3455"/>
    <dbReference type="EnsemblBacteria" id="EFI36013">
        <property type="protein sequence ID" value="EFI36013"/>
        <property type="gene ID" value="Dthio_PD3455"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="217" mass="25325" checksum="3CC848FB2F82663E" modified="2010-08-10" version="1">MSREDYNKEQKPKENETRDKSREEYPRQEEDSWEQEGEYLDFSGEEAGSHISEQEMKDLCRQNICPDCELLREQKNQALKAIADSENYKKRLAREKEEYCKYAVSSFIEEVIPVIDNLELALEHGRKNEACKDLAQGVEMTLNLFYQVLEKNNLKQVGSEGEDFDPNFHEAMAQQEREDMDEGKICQVMQKGYLLGDRLVRPAKVLVSKQCSPEKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMY7</accession>
    <name>D6SMY7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar hook-length control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3491"/>
    <dbReference type="EnsemblBacteria" id="EFI36048">
        <property type="protein sequence ID" value="EFI36048"/>
        <property type="gene ID" value="Dthio_PD3491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="7208" checksum="6CE111CFE1A552CE" modified="2010-08-10" version="1">MLTYGELLEILQSFDEEQLRQPAMIHIKDSEYMQQAQQVFVSDDDSAPVIIADICIQFEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN09</accession>
    <name>D6SN09_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869198.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3516"/>
    <dbReference type="EnsemblBacteria" id="EFI36070">
        <property type="protein sequence ID" value="EFI36070"/>
        <property type="gene ID" value="Dthio_PD3516"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1945747at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="87" mass="9797" checksum="6581B0EFE359DC8E" modified="2010-08-10" version="1">MQITIDIPDSLLKEISFGTQEPEREIKFILAARLVESGRISTGRAAEWLGISKPRFLQEMGRYGISAIPIDEQTLEQDVVNARHDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN55</accession>
    <name>D6SN55_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0473</name>
        <name evidence="2" type="ORF">Dthio_PD1529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869511.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0473"/>
    <dbReference type="EnsemblBacteria" id="EFI33150">
        <property type="protein sequence ID" value="EFI33150"/>
        <property type="gene ID" value="Dthio_PD0473"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34181">
        <property type="protein sequence ID" value="EFI34181"/>
        <property type="gene ID" value="Dthio_PD1529"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1970357at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8518" checksum="D47FC0BB5DA1D4B2" modified="2010-08-10" version="1">MHYRAVIKRTDDWWIGWLVDLPGVNAQERTREELLESLREGARDMLETEVPFEPGFEMEKVEVPEPEWVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN65</accession>
    <name>D6SN65_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869521.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34191">
        <property type="protein sequence ID" value="EFI34191"/>
        <property type="gene ID" value="Dthio_PD1540"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="36206" checksum="E162E9A45B97CD0C" modified="2010-08-10" version="1">MPRNARFTLPDRPAIYHIISRTALSGFPLGDIEKDKLLDIIRYFSRIYFVDILGFAIMGNHWHLAVKVYPHEYAYRDEVKERFARRYGEDVHFGDQDMEKFSKKWTDLSEFVREIKQTFSRYYNKRHNRRGFFWGERFKSMIVQEGHTLVNMLAYIDLNPIRAGIVKKPEDYRWCSLGYHTQTGNKDGLLSIDFGMKEWNEFNPSEIVRKYRQFVYETGAVDAGKGKVMDKKIVEKARKKNYKISRSDRFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDERKFTPVGGVEGLYSMKRLGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN73</accession>
    <name>D6SN73_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869527.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34199">
        <property type="protein sequence ID" value="EFI34199"/>
        <property type="gene ID" value="Dthio_PD1549"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891199at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="213" mass="24738" checksum="4D6D039D54A314C1" modified="2010-08-10" version="1">MTRKVIIFTDGMFMRRRVLERNHFLYKPREIREYCQKHLRPNDYLVRIYYYDCRPLQARGTSPLNGKEIDFSRLESARLRHQLFEGLRHAPNFCLRLGNMDWNGRDWNIVGSKVSPLLKKEITVDDLSDSDIRPGSETTQISVKMALDMVTLAARKAGDMFVLITDRTDLVPAMEMVRQEGVQVCLDNMHAPVSIELSEQADFISTQLNNKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN82</accession>
    <name>D6SN82_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869536.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1559"/>
    <dbReference type="EnsemblBacteria" id="EFI34208">
        <property type="protein sequence ID" value="EFI34208"/>
        <property type="gene ID" value="Dthio_PD1559"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="697026at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030916">
        <property type="entry name" value="ELWxxDGT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04534">
        <property type="entry name" value="ELWxxDGT_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1894" mass="206018" checksum="5D1ED94AC1A1E4BB" modified="2010-08-10" version="1">MPPSSHYKQDSVDKSQADALGNQSDSIAQHSTVDSGQTGVSSGRVVFAASDPEYGRELWISDGTSQGTSLLKDIQPLDSSNPGHLVRLSDGLVLFSANDGPGTSDDTHGFELWRTDGSESGTVLVKDIDPHSERGSQPASITPLGDGQAVFSATQTAGSGRELWVTDGTQEGTSLVKNLRPGTDNDGQPLSSNPQDFMALGNGHVLFTALDSDKGRSLWSTDGTAEGTHRLIEADTGFQLVRTGSATGSEPTAMGSGKALFTAIEPEPAIWTTDGTPSGTRVVQEVEEVTVEGSKDQSQLLQGGVVYDWHAGWATDGTSEGTWRLGGASQEAPDPVYFNNWDNIHSGPVEGPLQDVEANDSRLREVPPIELSDGTLLYEASAVEGHPDYWRFDGPEEYDYYNREWSLLWTTDGTHGGTQLVTDPYDDTLKVAKSWDPVPEFFNLGNDRILYHARGEGLFNESLAVTDGTSQGTEIITSEVSYADTFVPFYDNVWLFNGHRDGIWRTDGTATGTERLVADAWLNQDWFVELEDNRWLIEAEFYESYFGDFIKSELWITDGTPSGTGSVMDNLPGGTYIHDTVLLDNQEYLLSVEYTDPREIHSLYRLDADTFELERIQGAEEGSAASFYGFAKIDEPVQESIISDQISLEFNVETLSLDDYFSSILGSELSYQVSAMPEGMLFDAETGTITTDEDIGPGEHTISVESSNVEGDSVTDEFDWTVVDTGQLRIDSTGDWGRPHEDGSIISEEGSTIHVGHKDGSDWLFRLEQGRMIIREDILEVTGGGLWSGGVEFDAPLMAGDSGFEVNMQTLEVTGFEDDNSEDSARLVGDTIQMKFSDMEIEPEGLSLETDLLFGGSFVTLDTQDAPLLLSTSPQGPMFSPRIDGVGTGRWFKDDDALNLSVPGGSLSLELSNFGVYYDAVEDTFDFSGKAELSWGGKVQDQFRVIGVDTARSMELDLAGDAVDDDAGLFTRGENFLRFSPGSEEEPWSWDVSGSISYSAKSVPGYVETTRPLISELGLELDTTESSFGGNIKGQAPFLASGVELEIELGAFWDPIELEKLKLGLDGLNAPLGSTPFFIQGGELGVDGLSGRDEESALSYQGRIKTTLGPDTTVTPSPLHGSLGGEFTTGDIGLDFKIDSKVGYFVPGVVQSFTDPLVRWFGVNPARINDFTLLEATGDIEYDLAYGDIQTSLGIELLEGVVSAQAQLELYTRGDISHVDASMVATLHMPEAVPLIGGRGTSGTAMLEYVGDGNGQNSSVAAWRTIDLPFGLKTGVGLRADFAGNVELLGQRQIEEIGSWELHEDLSVVVLTARWEEAATDRTLELITPDETVLGEAEWSDHEDIVLVQELSDDYGRAVALQNPARGTWDLRLSDESGLGEVTYDASEMFQGPSTEILSVEVDAGSDQVHIVFDTELQDADSGVVQLYASLSPETVDELGRRITTDAIEVVQGQQEYVWDYREMAPGTYYVNAVTTAEGLAPDHAFSDEPVEVVGSADLVLSVEQEKGPIEETFLLTFTVSNEGERDSGSGILSIDVPESLVGNQPDSEFQSFTDKVTEVNFENIAAGDSADFEFLIPADFEDPAAPLQAQVQAAAYDADPSRNQILYGLFPASEEEQDDDDDPLLQDFEFHTQVDIAVGSPFSELFTDVQAMYTHYQVWTGRIEDGIVLDGNSTGWISAEHLADYRVGYENLEHNTLYVQGWKQGAPPGDWHSNAWRDGDYFDFPGPPGIEFNVDSDISVGTSFSQLFTDQDDTTTWYQLWTGELDQDGVVQGSLVDTQSGGGWVRAEDLNGLQVTGDQAGHNTIYVQAYSPELGMRDWQSNEWQNQEYFGFPEPWGYELAAQQKQIVHLDDGSKGNVADLPVAVADYVNSGDSGSLALQGVQDEQDSGDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNF1</accession>
    <name>D6SNF1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS/PAC sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869605.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1628"/>
    <dbReference type="EnsemblBacteria" id="EFI34277">
        <property type="protein sequence ID" value="EFI34277"/>
        <property type="gene ID" value="Dthio_PD1628"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="424"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="640" mass="72472" checksum="DAA15225AC664722" modified="2010-08-10" version="1">MTTKDDNNPSGHDAGRAGLQDLLQVFHGVNEALFVHDSKGGILELNERAMRMFGVDRNRALDLDFGRDFFAPHAPMRKLSRLCSRIDAGGNLLFSSTARIPGEGRQFSVEVYMKKIAWRGREAVLTTLRDITRHKEYESRLRIRRKQLEAILDAVPIATFVIDHEHKVVIWNKACEAFTGVLRDKTLGRAVDSRIFYPGPGRQVLADLVLEGNVEKMCTLYGDKNLASCLYIPDAYEARDTLNIQGEARDIYFLAAPYQDVQGRVLGAIETIQDVSDRTRVERALKSSERRLREITSNIPGVVYQYYVQDRDTKMFTFISDGVRWMFGLDPYKVLEDQELFFQSMDEDIRATFLQALESGGESDELQEFIFSMPGGPDGEKVWIKNRALCRVREEDGAVVWNGVLTDITQEKRLEIMRSEVERIVRHDMKSPLIGIAGLGRHLLKEDLSEKQRNFVVTIYQSGIKLLRMLNNTMSLLRIEQGTYTLKEERVNLAEVFCSLHEELLPSAENKGVKLEYYLNGAAMTRSDSVETKGERILLESLFANLLHNALEASPTGESVQVVIKRSKDSCLVDIHNQGAVPANIRDRFFDRYVTHGKQYGTGLGTYSALLIARAHGGDITFTTSEEEGTHLFVTLPIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNF3</accession>
    <name>D6SNF3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869607.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1630"/>
    <dbReference type="EnsemblBacteria" id="EFI34279">
        <property type="protein sequence ID" value="EFI34279"/>
        <property type="gene ID" value="Dthio_PD1630"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011973at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087990" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8272" checksum="DBB9833EDA61F7C4" modified="2010-08-10" version="1">MDKKILCLLAVLIFLLASCTRHHVTADTTHKVEIAPIHVTVDINLKVQKALDDALAFQGGMEDIFSEEELKQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNJ3</accession>
    <name>D6SNJ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain containing 21-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869647.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1670"/>
    <dbReference type="EnsemblBacteria" id="EFI34319">
        <property type="protein sequence ID" value="EFI34319"/>
        <property type="gene ID" value="Dthio_PD1670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="7417" checksum="1549D2AA89D43E53" modified="2010-08-10" version="1">MSIRHLAQEIYRLEKEISRLEKVQAAASGQDMQDLSFEISRLKKQRDELKARLESRKEKPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNK3</accession>
    <name>D6SNK3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869657.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1680"/>
    <dbReference type="EnsemblBacteria" id="EFI34329">
        <property type="protein sequence ID" value="EFI34329"/>
        <property type="gene ID" value="Dthio_PD1680"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1435688at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="18368" checksum="549E6E1382595988" modified="2010-08-10" version="1">MIIKKLRLRLTKFRRYWQHYVFQSLAATVALFALMMIINIQEKPVIIASIGATTFIVFTMPGYLTAKPRNVIGGHIIGMLCGFLASAAIMILENPPTIPMAMILSLAVGLSIFAMVVLDMEHPPASGTALGVALHGISVTVTLTILVSILFLSLVHKLFRHRLRDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNR3</accession>
    <name>D6SNR3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CRISPR-associated helicase Cas3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869715.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1742"/>
    <dbReference type="EnsemblBacteria" id="EFI34389">
        <property type="protein sequence ID" value="EFI34389"/>
        <property type="gene ID" value="Dthio_PD1742"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149839at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="7">
        <location>
            <begin position="92"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1095" mass="123908" checksum="8B0A829A6A262F95" modified="2010-08-10" version="1">MFVTIVSHCQGKARNRSFSLIDRYATRIGDNVWTTQITMEALKELCRGLKSKVSKFTSVAIYRNKGYNYQELYALIGSKKGYDRYGRYAIGTSTQTQRWPMFFRHAALLAAASGMSHDFGKMTEYFQGKILDNSIIKDPIRHELISAWIFDYLSNKGSWDDKTFINAWEELKGCLNSLQNGVINLWQGNESVQDAIKYNIITHHKMFGPTIKDMGNTPQAIPHQFNYSTFVNEDKRITEKMKLDMNKIKTAQIAAILKKIESKQNRLENIKSSPDYLNGLSFISRAALILADHEISSKDEGEVAKNELIANSKKKYSQDEKEKLEKGLEKQADQAKKDKRRKKITDSKHRQIKAEIEAQKQEIEAKKPKQSLDFHLKGVSKRASELVAHFNPEANGLPALEYYSYENLLLPGDTNSRFAWQDKAVDFLKEYKNTQTLVLNVASTGAGKTFMNVRALMALREGEPVRISSVLNLRSLTLQTHSAYKKDLGLQNDECVCTIGDLTIRKLHEAEHQDAEGVSASDKEDSETDYEEDVEVTATSLEANVPSWLNDLSKQKKGSTRDVIGAPLLVSTIDYLIAAGEPHRQAHHAVALLRAASSDLIIDEIDSYDVKAFVAVLRLITVHAMLGRNIVISSATLMPESVQAIADAFNTGLRMRKSAFSDTSMAIVTISDTVGPEDMGADSNVYNSYQSYCQQIAQAKTGTTKKFKIAKFNPDKASLHEAIANSVLDLHNDQGFAINDSQYEKVSVGLVRVANIKACMEIASYIKNTFSGNSEYEVRVCTYHAREVLSRRFYKESYLDHILNRKDKNNPNARIESFIKDELKSGKDSETRKNLILIVVATPVEEVGRDHDFDWAIIEPSSMHSIIQTAGRVNRHRLQIVSNPNIILLQYNVRYVEGEKTGRGVFVKPGFEIRDNQVSTHNQQYDLTELLKTKDDLAGIDFQNTPLDYSYIFGTPARSRSLFAEYDAGSIAGRINKIKDILSFEDRLWASKWFNEAFPLRSKEHKTQYHFKDVGKGNLGLFERRDTGQTPKMYIDSVLNDHEDLDNTFLSPTLQESLVFVHNKDKTLKIEHITTFDVYGNSDEISISWKGVETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNX8</accession>
    <name>D6SNX8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division ATP-binding protein FtsE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869776.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1813"/>
    <dbReference type="EnsemblBacteria" id="EFI34454">
        <property type="protein sequence ID" value="EFI34454"/>
        <property type="gene ID" value="Dthio_PD1813"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="25145" checksum="9057E376406F9091" modified="2010-08-10" version="1">MIQVKHLSHSFGRYWALKNISFSLDKGDFLFLTGPSGAGKTTLMRILHGSLPVQRGIASIAGFDLKSLPEKRLYQLRRQVAIVFQDFKILPDETVWDNVALPLQVRGMVPGQVHKRVRAVLRSLRLDNKSWCQCREISGGEQQRVAVARAVVINPKVLLADEPTGNLDKKLSMQLVEVFRQFHLHGTTVVLATHNEELINSLPGAKILCLREGAEAGCNWESAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNY0</accession>
    <name>D6SNY0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48 Ste24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869778.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1815"/>
    <dbReference type="EnsemblBacteria" id="EFI34456">
        <property type="protein sequence ID" value="EFI34456"/>
        <property type="gene ID" value="Dthio_PD1815"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="76"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="319" mass="35909" checksum="39C35BDC9D1A5C08" modified="2010-08-10" version="1">MNINTYTSHKWLNLLHSVLILTGMAVILCLLGWLIAGRPGIVWAFIIGTAVVIITSRISPQAVLKMHNARLLDYSHAPRLHTMTRELSSRAGLSFQPALFYIPSPVVNAFSVGQKKNAAIALTDGMLRSLSYREILGVMAHEISHVRNNDIWIMNLAEAANRVTGLLSLTGQFLLLLNLPLILTQDYHISWWIIFLLIFAPTLSTIMQLSLSRTREFDADMDAAMLTNDPMGLARALAKLEYTTRSWLDRFMRPGQKYGLPSFLLTHPRTEDRIQRLISLAGDINEQPWQTPDHSYMDLKAARLPAGAGPLRRLLGNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNY3</accession>
    <name>D6SNY3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869781.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1818"/>
    <dbReference type="EnsemblBacteria" id="EFI34459">
        <property type="protein sequence ID" value="EFI34459"/>
        <property type="gene ID" value="Dthio_PD1818"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="6"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="686" mass="75522" checksum="52578A243BB5E4EF" modified="2010-08-10" version="1">MLDKLEKQRTYALVGHGGTGKTSIAEMILYQSKAISRLGSIEDGTTSLDFEPEEIKRRGSIQPGFFVYTWEKNRHFLVDTPGDNNFIGDISYLLKAVDGVVFVVDAVDGAKPLTKKLWTEVQDAGLPALVMVNKMDRERADFRMAYDSLVNLLGIKPVVLYMPIGAEADFKGLVDVLEEKAYYFDQEGRLTPGDIPEDMQESVAEMRELAMENIAESDEELMEKYLEEGSLEMQELYSGLRKGVLSGEVVPVCSGAALENKGGAKLLQAVQSLLPSPLEHPDWEGEDGRQRRSHPEEEPAAFVFKTITDPFSGHLSVMRVLSGTISSDMILANPVRDEKEKLGQLLLLEGKKQTQFKEAAGPGSIVAAAKLKSTVTGDTLCSEKDPFVLKKPQLSPCILSYALAAQEKGEEDKVFAAVHKLLDEDINLQLTRNEETKDMLLSGMGQLHIEMAVEKARRRYKAAVVLKTPKIPYRETIKGKTEVQGRYKKQTGGRGQFGDCWIRLEPLQRGEGYDFVDAIVGGVIPRTYIPAVDKGIQEAAARGVLAGYPVVDFKVTLYDGSYHSVDSSEMAFKIAGSMAFKKAVEKCSPVLLEPIMLATVFVPDEYMGDVIGDLSSKRGRVLGSESDKGITSVRAHVPMAEMLQYAQDLRSMTGGQGTFTMEFAHYEECPGPIAEKVIAENSAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNY5</accession>
    <name>D6SNY5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869783.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1820"/>
    <dbReference type="EnsemblBacteria" id="EFI34461">
        <property type="protein sequence ID" value="EFI34461"/>
        <property type="gene ID" value="Dthio_PD1820"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1341636at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="376" mass="43120" checksum="6789045038ED5C27" modified="2010-08-10" version="1">MNDTREPCLPAHLEPPQHILVDPEVIHSPITARVLSRLPGIPWSVCRNYQEKLQKHGPGARILYLKNYKGRFMRFCPGTSRYHCCGYRIIHIGENCPLNCSYCILQAYFQDRVLKVWANQQDLFRELEEHLADKNRLFRAGTGEFTDSLALEAITGYTGDLAAFLGQYPNICLELKSKIVDLGWMSRVSDPARVLPAWSVNTPEIIALQEKGSAGLQERMQAARECVRQGFRICLHFDPVIHYPGWQKGYALAVETIFDYVNARDIAYMSLGSFRFMPELEKILMHNHPGADYIYNEFITGLDGKKRLLLPLRLKQFRFLARKLKNAGMGTNMYFCMESEHVWQDVLGYTPRDLGGLDNHLLRLSFQADQFSALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP05</accession>
    <name>D6SP05_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(Uracil-5)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869803.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1840"/>
    <dbReference type="EnsemblBacteria" id="EFI34481">
        <property type="protein sequence ID" value="EFI34481"/>
        <property type="gene ID" value="Dthio_PD1840"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="43080" checksum="368ED3AFCCD6A86A" modified="2010-08-10" version="1">MQELELTVERLIWRGRALARLESGQVVILEPGVFPGERILAQVTKSTGDHLQARCTRLLEPAEHRQEHPCPLGDLCGGCRFGVLPYQVQVKIKHQVLQTEIRRALGRKWSGHAPEEILVFSSPESWGYRWRGQTEVLDGRPHVKALGRNHPLHCPRCLLHAPVLAVELPRICQDLPPGRYTMAASPLDHKVLAHTSPEWLKLPLEKSGISLQVRPGSFFQANWRLNQDLVQYVLSRLAHLDSLADLYAGAGNFALPCAAGGHKVLALESDSRAAKGALRAAREGGLNNLRIHTGDLRRREAMQTLKKFAPQGLILDPPRSGAGRNLQSLAGLESLQRLAWISCDVVNTCRDLKPFLEAGWRIREAAMFDMFPQTWHMEAVFVLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP97</accession>
    <name>D6SP97_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBA/THIF-type NAD/FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869893.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1945"/>
    <dbReference type="EnsemblBacteria" id="EFI34573">
        <property type="protein sequence ID" value="EFI34573"/>
        <property type="gene ID" value="Dthio_PD1945"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="60"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="279" mass="30284" checksum="C7166906C6AA050C" modified="2010-08-10" version="1">MHTKGLVQDLAGHSHALDNYPFACILDAPLLDLAGKYNIQPWQAQVVALENQVCPERYIRNFKTMSLDMQLDLARSKVLVVGAGGLGGYVIELLVRSGAGRLFVADGDVFELSNLNRQLLGTTHLTGRPKVEAALQRARDINPFARVETFGTYLQPDDLPGLLPETDLVLDCLGGVEFRQELLQAAQGHHCPLVTGFVAGNTGLASTVFPGDKSPAAFWQADNDQGAEITLGNVSYTVSMIATLQAREAIHILTGQAPCLRNRVFLADMHTCSFQSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPD6</accession>
    <name>D6SPD6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulf_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869932.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1984"/>
    <dbReference type="EnsemblBacteria" id="EFI34612">
        <property type="protein sequence ID" value="EFI34612"/>
        <property type="gene ID" value="Dthio_PD1984"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1518604at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="38"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="175" mass="19142" checksum="49DFFE2FB3CA5116" modified="2010-08-10" version="1">MKLIIIGLITGILFGFLLQKARVVRYDKQLGALRLLDMTIIKFMFSTVLVSMVGIYLLYDLGQVDLSIKTTIMGANIIGAILFGLGWGMLGYCPGTSLGALGEGRLDALWGILGMIAGAAVFAQAYPVLKNTVYAWGDYGKITLPQVLNISHWPVILAFIIIGLLLFVWFERKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPK8</accession>
    <name>D6SPK8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative adenylylsulfate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2056"/>
    <dbReference type="EnsemblBacteria" id="EFI34684">
        <property type="protein sequence ID" value="EFI34684"/>
        <property type="gene ID" value="Dthio_PD2056"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="217" mass="24694" checksum="0EA17DE54513557C" modified="2010-08-10" version="1">MQTLAAVATGLFCAASWLNGNTGRDPQQPGTVIWFTGLPGCGKSSICDFVLSMLRDKGFDPVLLRMDDRRKQYFPRPEYTREEREKAYGLFAREAVEYARQGRLVLMDATAPRLEMRKRVRDRVPVFAEIHIYCTLDTAMHRERSRPGGQVMAELYDKALERKKTGRDFPGLGMVIGVDQEFEVDPEAEMTLENDHLSLQEAGQKVSNFILENILCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPQ4</accession>
    <name>D6SPQ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VI secretion protein, EvpB/VC_A0108 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870048.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2103"/>
    <dbReference type="EnsemblBacteria" id="EFI34730">
        <property type="protein sequence ID" value="EFI34730"/>
        <property type="gene ID" value="Dthio_PD2103"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="683477at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010269">
        <property type="entry name" value="T6SS_TssC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044032">
        <property type="entry name" value="TssC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044031">
        <property type="entry name" value="TssC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35565">
        <property type="entry name" value="PTHR35565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05943">
        <property type="entry name" value="VipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18945">
        <property type="entry name" value="VipB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03355">
        <property type="entry name" value="VI_chp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VipB" evidence="1">
        <location>
            <begin position="83"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="VipB_2" evidence="2">
        <location>
            <begin position="393"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="503" mass="56581" checksum="14D66A84036B05B6" modified="2010-08-10" version="1">MAEEKQQAEKTEEQTQEAIDLKRFLSSMRLSTEVSEPVPMVQDGLSSVQENISDEDRFISGLAALLMNVDPSTGRFDKALIQDIVAQIDEMVNSQLNEIIHHDNFKQVESNWRSLNDLIQNTNFKANVMIDILDVSKDELFEDFESNAVDITGSALFKKVYVSEYDQFGGKPFGGIIGLYEFTHTPQDEFWLKTMGKVAAASHAPFLSSVSPSFFGCDSIEELAGIKDLEGLMNHPKYGSWNQLRDSEEAAYLGLTLPRYIVRLPYDPAKNPTGDLNFYEDVKGDNNEDYLWGSSAILFAQNMVRSFVQSGWCQYLRGPKGGGLVTGLPVHAFNIRGEEEIKVPVEMVVPDYRELEFANAGFIPLVYRKGSAEAAFFSAQSLKKAKKFKDPKDTENSQLVTNLSYTFSVTRVAHYVKSIMRDNIGTSADAAYIKQALEKWIFKYVTTVVNPDDLTLRNYPFKAATVDVVPREGMIGWYDCSISILPHIQFEGMDVELKLDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPW3</accession>
    <name>D6SPW3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870105.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2166"/>
    <dbReference type="EnsemblBacteria" id="EFI34789">
        <property type="protein sequence ID" value="EFI34789"/>
        <property type="gene ID" value="Dthio_PD2166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="255" mass="29322" checksum="20F48725A9E4AA5B" modified="2010-08-10" version="1">MDKTEGENAGHLAARAAELVEKLRFHEIRAAVLKGSIRQYSIKVVLPQGQLVIHYSSKKNAFKYQLENVSDIELQQKIKECLDDSAKTVEAGKANGHFSAQEHQKDFTDMVSAFQEYLKSHEVDSFIKQAFYLPVPRVQMAVGSKDAGWGYLNIYQTKKGTCPKFHEIREAGKRELLKTLWDSFSQPADDDLLEVEYYLSVLKPYKHLDFDFLVLAQSLAKAWNRRMADPLDADDLRYDFFRMEKCIDKLFSKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ88</accession>
    <name>D6SQ88_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2305"/>
    <dbReference type="EnsemblBacteria" id="EFI34914">
        <property type="protein sequence ID" value="EFI34914"/>
        <property type="gene ID" value="Dthio_PD2305"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="43"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="155" mass="18191" checksum="0F6035B75F0B91DB" modified="2010-08-10" version="1">MMERLLPTRRTNAPERRTAMRTPMDMFEMFEDMWRSPFRGIEELDQQFTPAIEVSEKENEIVVRAEVPGMSPEDMDIRVENNHLILSGEKKHEHKDEKENQIHREFTYGRFYRTIPLRGEVDPGNVKAKYKDGVLTVNVPMNPESTRAKKIAIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQA2</accession>
    <name>D6SQA2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870242.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2319"/>
    <dbReference type="EnsemblBacteria" id="EFI34928">
        <property type="protein sequence ID" value="EFI34928"/>
        <property type="gene ID" value="Dthio_PD2319"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="12"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="682" mass="75999" checksum="82B3DB63C6A4A037" modified="2010-08-10" version="1">MAAKKPSSSRLEKIRNIGIIAHIDAGKTTLTERILYYTEKIHRMGEVHEGTATMDFLPEEQERGITIASAFTSCLWREKIINIIDTPGHVDFTVEVDRALRVLDGAVAVFCAVGGVEPQSETVWRQSTKYHIPKLAFINKMDRPGADFEAVLTAMQEKLGAVPLPVQVPLGEGEDFKAVLDVISGQKLVFENQSLGRTIERLHPDSQEQQLVTKWRSILVEALADHDDQIMEDFLEGRDIPAEKLLSTIRTLCLQLKGVPVLSGTALKNIGVQPLMDAICEFLPSPWDVPQVQGLDPATHKSRSFPVKSSAPLSALVFKVSMETGRKLVFLRIYSGTIKAGDMVFNSTQNIQERAARLFTVHARHREKLEQAGAGEIVAAAGMKDARTGDTICSEKDPILLEKISDYVPVISLALEPRNSQEEEKLTFALDRLLQEDPTLFFERDQETDQIIISGMGELHLDVVLHRMRREYGVDFRAGNPQVVHQETIQEKARSHGEFARELGEEFHYGWVEVQLEPRGRGQGNRISLEVDYESWSQAWLDAVYEGVEDALQAGEMQGFPITDVHVRVKRLKSEKGADSIGFRLAAVQAVKSAMNQAGPVMLEPIMNLEIQTPADFVGECINLLGAKSARVENMFDRGEQKIIHSLAPLRNMFGFSTDLRSATQGRAGFTMKFHSFDTMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQE7</accession>
    <name>D6SQE7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870287.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2365"/>
    <dbReference type="EnsemblBacteria" id="EFI34973">
        <property type="protein sequence ID" value="EFI34973"/>
        <property type="gene ID" value="Dthio_PD2365"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="393" mass="41981" checksum="E85BE140589A45F7" modified="2010-08-10" version="1">MAVREQVYGFFIPSVTLIGLGAHKEVPAKIKALGGNKPLVVADKGITAAGITEQITSLLKAEGMDCVVYDDTIPNPTDNNVHDGVEVFKKNNCDSVITLGGGSSHDCGKGIGLVVSNGGKIHDFEGIDKSEKPFLPYVAVNTTAGTASEMTRFCIITDTSRKVKMAIVDWRCTPGVAVDDPLLMMGMPPALTAATGMDALTHAVEAYVSQAATPMTDACAEKAISLIFQYLRPAVANGQDVDAREGMCYAQYLAGMAFNNASLGHVHAMAHQLGGFYDLPHGECNAILLPHVEQFNLIAKMDRFITMAELMGENIEGLGRREAAEKALEGIRKLSKDVGIPSGLIELGKRYGKDVKKEDIKTMTANAQKDACGFTNPRCPTDKDVEAIFEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQP8</accession>
    <name>D6SQP8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polar amino acid ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870388.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2468"/>
    <dbReference type="EnsemblBacteria" id="EFI35074">
        <property type="protein sequence ID" value="EFI35074"/>
        <property type="gene ID" value="Dthio_PD2468"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="15"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="229" mass="25734" checksum="BC73F4D7DC1AC040" modified="2010-08-10" version="1">MEIIIESLPRLLGGAVITLEITFLSVLLGFVLAVPLAVMRVSRLRCLWMPVYAFTFYFRGTPLLVQIFLIYYGSGQFQVFLDSVGLWHFFKSPWFCSVLALTLNTAAYSAEIFRGGIQGVPRGEVEAARACGMSGLLLYRRIVIPKALRIAWPAYTNEVIFLLQASSLVSIITVMDITGVAREISARSFAFYELFLAAAAIYLVLVYGILWIFKRIENRINAYLQVGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQS1</accession>
    <name>D6SQS1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870411.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2491"/>
    <dbReference type="EnsemblBacteria" id="EFI35097">
        <property type="protein sequence ID" value="EFI35097"/>
        <property type="gene ID" value="Dthio_PD2491"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1665714at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="175" mass="19893" checksum="9BFE0AE165C08FF5" modified="2010-08-10" version="1">MLLSDWLPLSEIPDQGVKYFFQDDSRWILLWEKFGLDCGMEKSLVSNLEVLPQPDGVYFRGRIQGQVAMTCSRCLEPGTVDIDYNIDVYESFEADPEDPPGYSPLKFEDGQWWFSPEQLAWEHFVLALPDKPLCSGDCKGICPACGENINTGLCACPEESFDPRLAVFRNLKINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQT5</accession>
    <name>D6SQT5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly PilZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870425.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2505"/>
    <dbReference type="EnsemblBacteria" id="EFI35111">
        <property type="protein sequence ID" value="EFI35111"/>
        <property type="gene ID" value="Dthio_PD2505"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033GSS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1865358at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="131" mass="15339" checksum="2D813269923F0264" modified="2010-08-10" version="1">MQKQEERRQYVRIPKNYRVELQPLEFPLAAQKKIRVESADISSGGLRLSCDEKFGEGQTVQVRVYISGLNKHHPGFFKVFESDAGQYLQAVSEVSWVREKVAFELYEMGLKFVDVYEDDWQALKTMLDRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQY5</accession>
    <name>D6SQY5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870475.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2559"/>
    <dbReference type="EnsemblBacteria" id="EFI35161">
        <property type="protein sequence ID" value="EFI35161"/>
        <property type="gene ID" value="Dthio_PD2559"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="251" mass="28560" checksum="8BE5AC6D5BFE8F41" modified="2010-08-10" version="1">MSFYWPAYNELAWTEELLADPAEYEYEAGFYVELIKGTAKGDTPRTLLHLGSGAGMHDCVFKRHFTVTGVDLSPGMLEKARAKNPDVQYHKGDMRSIRLGQKFDAVAIPDSTDYLVTRDDLYRAVNTAVEHLKAGGVLLVTAKPKETFQNNNFSYTGEKDGLHLTLLENNYINPYRHDTYEAVFVYLIRQQGELTIHTDHHVLGLFSKRTWEQAFRDAGLDMQEKKLHGVYERYIIDGGSYPLTVFAGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQZ4</accession>
    <name>D6SQZ4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="7" type="ORF">Dthio_PD2568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870484.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2568"/>
    <dbReference type="EnsemblBacteria" id="EFI35170">
        <property type="protein sequence ID" value="EFI35170"/>
        <property type="gene ID" value="Dthio_PD2568"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="201"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="209"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="613" mass="68494" checksum="47167A78D6B8CDC9" modified="2010-08-10" version="1">MQDKQKQQKPDFRNDTFLHVLILLFLVLLFWNFAGPMWQPAQISYSDFLAQLREDNVEEVTVRGDRIEGSVHEEVEKDDITYTDFVTYTPAFGDDQLMPLLQEKDIQVYTQPERSPIFWYLLLSTIPLLLIALLIYSQYRKMQGGGGMFGLGKSQAKKFDQGKQSTTFQDVAGAREAKVELMEVVDYLKDPGKIHEMGGKVPRGVILVGPPGTGKTLLAKAVAGESGVSFLSITGSDFMEMFVGVGAKRVRNLFEEARQNAPSIIYIDEIDAIGRRRGSGMGGGHDEREQTLNQLLGELDGFEEHENIVVMTSTNRPDILDPALTRPGRFDRRILVDLPTVQDRVELLQVHSKNKQLGQDVDLERLARETPGFSGADLENLMNEAALMAARDGRSHINSQDIETARDKILMGLKRHGLVMTHEEKRMVAYHEAGHAIVGAVLPHADPVYKVSIVPRSQSMGATQQFPDREQYIFAREYLLDRLAVMMGGRCAEVQVFSTATSGAANDLQEATKIARRMVMEWGMSEAFEHMAPGGPGKEIFLGEDLGKTREYSESTAQKIDLEVEAILKKAYERANEVLSSRRQAMDELAESLMQNDEVSGETVYAIVEGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR39</accession>
    <name>D6SR39_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na-Ca exchanger/integrin-beta4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870518.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0478"/>
    <dbReference type="EnsemblBacteria" id="EFI33155">
        <property type="protein sequence ID" value="EFI33155"/>
        <property type="gene ID" value="Dthio_PD0478"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="973373at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0401">Integrin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="5">
        <location>
            <begin position="199"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="338" mass="36626" checksum="0147B13F99CBDCFE" modified="2010-08-10" version="1">MKKFDTTLTSHEAWSGVAKVSDGYKQGSSVLHESGIFIITAGHVVEDFHLSGGSVDFGTDTREIIGYGKHPGYAITDSGMYHDIGLFVLDRAAPRDAQRYELYREHDEAGQQVDLTGYGGSSFWSGSNTVAGLAGEYVTHGSVYHQLAFKRDTGDMIAGGDSGGGMFIDSKLAGVHSYTSGDIGVSTRVSTYTHWIDQTTGTVQDPEARSSEPPSRDSVPMEVSEGEGVWFLVELDSPASREVSVDFYTRDGTAEAGYDYIPTEGTLTLAEGDQWARVWVQTLANSNQGERDFSLVLENPEGAKFPEGKEELTAQRVVHDDQVGLAGVTQLEPELFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR83</accession>
    <name>D6SR83_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FlgN family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870557.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0525"/>
    <dbReference type="EnsemblBacteria" id="EFI33199">
        <property type="protein sequence ID" value="EFI33199"/>
        <property type="gene ID" value="Dthio_PD0525"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034BQG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1890021at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007809">
        <property type="entry name" value="FlgN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05130">
        <property type="entry name" value="FlgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="156" mass="17827" checksum="DCAFF156B9F56933" modified="2010-08-10" version="1">MDIMAGLKRQKLALKLLHLLLQEEYAALMNNQPDKVSSLEFSLQELVRQMIREKEDVINAVQEAGFEGLGDYISSLDKKRAQKHMDLMNQLQDEEKKMALQAMKNATMAKALSDQSTALAREFFQQVSPRKPDTYSADGRRYAELSREGGFIRGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR87</accession>
    <name>D6SR87_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagella basal body P-ring formation protein FlgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0529"/>
    <dbReference type="EnsemblBacteria" id="EFI33203">
        <property type="protein sequence ID" value="EFI33203"/>
        <property type="gene ID" value="Dthio_PD0529"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017585">
        <property type="entry name" value="Flag_basal_body_FlgA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039246">
        <property type="entry name" value="Flagellar_FlgA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36307">
        <property type="entry name" value="PTHR36307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13144">
        <property type="entry name" value="ChapFlgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03170">
        <property type="entry name" value="flgA_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChapFlgA" evidence="1">
        <location>
            <begin position="206"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="327" mass="37369" checksum="2398798CBAB9E37C" modified="2010-08-10" version="1">MNKEKFMKTKILSCCMAAAMFFLLLSSPAWAGEGLFWIDEHVAVSGDVITFGEIATPRNSEAEQYWSDIKDTELWRAPNAGQRIVLDRARVQERLEVTLGELAEASIIPREIIFQRGRRVLDDDKLERMVRDYIGPKVTSQGERIEFRDFRMPSPIFLENPYEEVEIESVRDPGPGRNSLRFVVRDGHGEVVRRHTGNVFVDVWVTVACAERPLNRGDVIEPGDVRFEEKNLAYIRREVWDGESGPWRIRSSIGQGQPIYKRHLEPVPMVSRGAKVDMVYEGNHLTLVVPGEVLEDGQRGDRIMVRNMQSEKEVRATVESSGRVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRD3</accession>
    <name>D6SRD3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870607.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0575"/>
    <dbReference type="EnsemblBacteria" id="EFI33249">
        <property type="protein sequence ID" value="EFI33249"/>
        <property type="gene ID" value="Dthio_PD0575"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1258500at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="37292" checksum="D7F7FE792109A193" modified="2010-08-10" version="1">MKKKKQQSTEAVSPESSAWSAPLLHAALLLAALGLGLDLIVRRTMGVSICPTEGCLIVGEYVRIGEENLVLLGFVFLLVLWLAYFFARRYNRAWLWGLATVMLMGALSFDGSLMGFQFLVIQEPCLLCIIVACSLFLILALFALVRKKAFLFLLGLCVWIAGGAAGSILQPPATTATDRPDLENTAVIQWSHTGAQDWPRFHFFFSMHCPLCTEIMLHLAQEGSEPLDYTWNFIPLDTEPDDLKKIAALKKMDLSDKNPFYEILLMEQYPGTPDVEIPGHLQELILQARFYFQVQGFRGVPITIVQKGPDEKKVLTGAQEAMQYFRDKGILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRL1</accession>
    <name>D6SRL1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNF2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0654"/>
    <dbReference type="EnsemblBacteria" id="EFI33327">
        <property type="protein sequence ID" value="EFI33327"/>
        <property type="gene ID" value="Dthio_PD0654"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="40"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="324"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="638" mass="72483" checksum="F45F9DAAABBD62F5" modified="2010-08-10" version="1">MHNRVDEYLLKQEVDELSREELPSLEGISTALYPYQIEGVRFGLYRKAALIGDEMGLGKTLQAIALGILKKEVFGFNRVLVITLASLKEQWKREIEKFTREQAVVVAGSAGMRQQTYFQDESLFKITNYEAVLRDVSTLRRFKPDLVILDEAQRIKNFATKTADVVKSLPRKHALVLTGTPLENKLEDVYSIVQFLEPHMLAPLWKFAADHFMLSREKKDKILGYRNLDLLHEKLKPLVIRRRKEDVLKDLPDQVTNTYYLDLSEVQAKMHDGYKQYLLPLLNKKFLTPMDVRRIQELLLQMRRVCDSTYLVDRNTRISPKLKELEGILDEIVVQSGRKMVIFSEWTTMTYLIAKQLSRMGINFVELSGKIPVHKRQALIDEFTNNPECKVFLSTDSGGTGLNLQAADCVLNFELPWNPARLNQRIGRVNRIGQTSTSINVINLVSKNSIEEKILAGIHLKTELFSGVFDGGVDMVEFSREKRNQMLNELRAMMGQEMEEDLGGKESRVSEDIPEDTPHFLNPQALAESQQEDFPGTQVQGASEPEDRPGGEQTAMAEESQAANDAGQSRHDTGSEPGVPDKSPEKMEAVLNQGLEFMSGLLEMATGQKLNKTEEDKPMLKVDRETGEVTMKFRLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRV7</accession>
    <name>D6SRV7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870775.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33423">
        <property type="protein sequence ID" value="EFI33423"/>
        <property type="gene ID" value="Dthio_PD0756"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="338" mass="39806" checksum="20A3E8A57E7AA847" modified="2010-08-10" version="1">MSTTNIHDSTIKYFLSDRLNAISLLKSMLPEEIVKQLDFNKIYYEKDSYLPKSLQGYYSDLVVSVPTKCGSYVAKVFFLLEHKSTFKKNTPLQFLRYILEFWEQYQKNTGETRLPVIIPILIAHPEEGWKPTKVSDLVDLPSDDFKIFVPDFNFLLYDAVNDDPEDYDFDETLKALFTLWRYSRSPEFMQGVQKAFQLIKKVDPKARLLDFVQMILHYLEVTRDEKEYIDIQKIAETEIDEGEEYMGTIAEMFRREGDERTEQRFLQEKPIWEKQSELKATQETLIDIATEAYGPLPDILHEKIKSIQSQENLRALNRKVIRTQSMEEFTELVNRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRY6</accession>
    <name>D6SRY6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">atpB</name>
        <name evidence="14" type="ORF">Dthio_PD0786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12 13">Cell membrane</location>
            <topology evidence="12 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 13">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870804.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0786"/>
    <dbReference type="EnsemblBacteria" id="EFI33452">
        <property type="protein sequence ID" value="EFI33452"/>
        <property type="gene ID" value="Dthio_PD0786"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="7 12 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 12 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="226" mass="26257" checksum="03D7D4C56999CB8C" modified="2010-08-10" version="1">MEDLYQWMFLREFFHALGLNIPQHVLYSWFFIVILVLVGWMATRRMTLVPKGVQNFFEFLIKAVEDFVVANMGEQGRRVFPVLFTLLIYIWVLNVSGLVPSIDAATANINTTACMALFVFVYYNYWGIRIHGAAYIKKFMGPYWWFAPVMLPIEIVSHLARPLSLALRLFGNIRAEEITIAVMFILAPILGSLPIFILFLLLKTMQAFVFFMLTMMYLKEAFEEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS75</accession>
    <name>D6SS75_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="8">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Alpha-IPM isomerase</fullName>
            <shortName evidence="8">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">leuC</name>
        <name evidence="10" type="ORF">Dthio_PD0875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870891.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0875"/>
    <dbReference type="EnsemblBacteria" id="EFI33541">
        <property type="protein sequence ID" value="EFI33541"/>
        <property type="gene ID" value="Dthio_PD0875"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749418at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011823">
        <property type="entry name" value="IsopropMal_deHydtase_lsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02083">
        <property type="entry name" value="LEU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="44915" checksum="A50BD18DB2036A16" modified="2010-08-10" version="1">MGKNLAEKILQKHSPEEIKKPGQIIPCRVSLVLANDITAPLAVDSFRKMQAPRVFDADKIALVCDHFTPNKDIASAEQVQKVRRFAREMNITHYYEGGNVGVEHALLPELGLVGPGDVVVGADSHTCTYGGLGAFATGMGSTDIAAAMALGETWFKVPETIRVNMNGSLDEFTTSKDLILNLIGRIKVDGALYRALEFAGDTLPELDAEARMTMANMAIEAGGKAGLFPVDQVTLDYCREHGRLGDHLLEPDGQAGYCMQVDMQVSGMPPQIACPHLPDNVTGVDDLEEIKVDQVVLGSCTNGRISDLRQAAHILKDRKVNKNVRFIVLPATPKIYAQALEEGLLEIFLKAGGIIGPPTCGPCLGGHMGILASGETCLATTNRNFKGRMGSLESKVYLGSPYVAASTAVAGRIIHPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS85</accession>
    <name>D6SS85_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase (Ferredoxin)</fullName>
            <ecNumber evidence="16">1.4.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Dthio_PD0885</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="16"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870901.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0885"/>
    <dbReference type="EnsemblBacteria" id="EFI33551">
        <property type="protein sequence ID" value="EFI33551"/>
        <property type="gene ID" value="Dthio_PD0885"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5568at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016041">
        <property type="term" value="F:glutamate synthase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="13"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI33551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1521" mass="166190" checksum="5DE77A913B4201B2" modified="2010-08-10" version="1">MFSTPRIQEKDACAVIALVDKQGSPTHANIVQTIDALRKMGHRSGDINGEGDGCGLSTDLPRGVWMKRLSRSGLNPYLAESRGFFAGHFLIPLDLKDKWSHIQEKARAILKDEGFDLLTEIEGNTRNQELGPRASSEAPLFWQLAGIAPDGSRRAAARRLFLAQMRLEEELPRLETASLSLDNAIYKLQGMPDMLPKVYPELRDPDMASVMTLGHSRYSTNTLPTVLRSQPFSMLGHNGEINTIEKLESTARMLGIRPVPEGSDSQNLNRILEGLVHQHGLDIMEALDMVFPPIHSLVKNYPDELKNLYSLYRWFFPCSAQGPAAIVSRYGDMCLGSVDALGLRPLWFGESETHYFLSSEKGVVDLKYNVRDPRPLAPGEKIAIRCGREARAQVMDYNTCQEQLLKIMQGRPGSNEKLAFLYSMFNHEPAFCSDHEALELVRQFMSQPMNTDHSGRLSAYGWQKYDINIRKRVAQEGREAIGSMGHTGPLACLMTHALPNLADFFKENVAVVTNPAIDRQREAEHFSTRVVIGSGPDIRPQSSRQALGLELGTPVLLGGRGLEDTLTLKQEQNLARKFNSALLEEVMAFFTGQGHDTARAAVLDCTYVPGQGLNLALDSLAHQAAEKVSSGSMLLVLDDSGSFQEERVHMDPGLATAWVVEKLVRAGLRRKASVVVRSGAVRNLHDIMFLVGLGAEAVNPYLLWRISADFATEKLSPEKAVENTMQVLQAGMEKIMSTMGIHELCGYGRIFSSVGLSRHLAEQMQVANFCESENTGIGLDFLEKQDSLRLQRAGDTTETGLYSEPSRNQKVGRTLRKVAQGRTGYAEMAASLEEIDREIPTGMRHLLSLREAPSDDQLTQDQVDISVGRHDLPLVIAAMSFGSQGENSFRAYAMAAMKANIICMNGEGGEIPDMLGGFRHNRGQQIASGRFGVFMGLLNSTDFLEIKIGQGAKPGEGGHLPGSKVSPMVAQARKCKPGITLISPSNQHDIYSIEDLAQTITELKTAHPRARVSVKIPVTSGVGTIAVGIAKAGADIINLSGYEGGTGAAREHAKRYVGLPVEIGVSRAHQALVESALRHKVELWCDGGVRNGHEIIKLILLGANRVGLGTLALMGIGCISCRRCHLDRCPMGISTQLRTSEEAKEKGVKSFRPRTAEVEAENLARLLGAIGDEMRMRLARMGQKNLSDLTGRTDLLFQEQGHDQVDLSDLLRTADHPVEDEVSEQGRVVRKPLNYLTRLISDLAMDHFSAGDLRVNFAEEGVSSSDRAVGTYLAGAMERRYPERRDLLAALRLGDSVPGNGLCAFGTSHLEVVVQGGSQDGAAKGFFGGQLGVLKGNNYQGRYIDGSTGKSFAYGAIDGLLMIQNMADSRACVRLSGADVVFGGRITAPVNDQSGNLAVNSHLKGFAFEYMTGGRAVVLGDPGPWLCSGMTGGVVYQCLYPEYDFGQDNIKRRLARGANVVITPISDQGIKDVQELLGPYIQELEKSLQMEEAAIVKDILEHAQTRFAAIVPKPLWVKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSB7</accession>
    <name>D6SSB7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integration host factor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0918"/>
    <dbReference type="EnsemblBacteria" id="EFI33583">
        <property type="protein sequence ID" value="EFI33583"/>
        <property type="gene ID" value="Dthio_PD0918"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13835">
        <property type="entry name" value="IHF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005684">
        <property type="entry name" value="IHF_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="11167" checksum="E8D20D439E5A3809" modified="2010-08-10" version="1">MVNTLTKSDLVDRVYEQSDRKRAEVKGQIEHLLDIIKQAIKKDHSLLISGFGKFETYDKKPRKGRNPQTSEAIILPGRKVVVFRLSRKFRSEINQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSC2</accession>
    <name>D6SSC2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tyrS</name>
        <name evidence="11" type="ORF">Dthio_PD0923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870938.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0923"/>
    <dbReference type="EnsemblBacteria" id="EFI33588">
        <property type="protein sequence ID" value="EFI33588"/>
        <property type="gene ID" value="Dthio_PD0923"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02007">
        <property type="entry name" value="Tyr_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024108">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF1">
        <property type="entry name" value="PTHR11766:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="10">
        <location>
            <begin position="338"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="227"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="400" mass="46372" checksum="6E4B3B6C1D9C24DB" modified="2010-08-10" version="1">MSWNHQEAMALIRRGSVEIVSESELLKKMDRKKPLRVKAGFDPTAPDLHLGHTVLIQKLKHFQELGHHVLFLIGDFTGMIGDPSGKSETRKKLTRQEVIQNAETYKRQIFRILHPEKTELVFNSTWMDKFHAADFVELCSRYTVARMMERDDFDKRFRENRSIAVHEFLYPLIQGYDSVELKADVELGGTDQKFNLLVGRDLQREYGQEPQVILTVPILEGLDGVQKMSKSLDNYVGIEEPARDMYGKLMSISDELMWRYFELLSDKNLNDIEAMRENVEQGRLHPKYCKEELAMEITARFHDRQAAEKERENFNRVFSAHEMPQDMPEFSVSPAENKRLADILVESRLCPSRSEAKRLCRQKAVGLYNGEKLTDPEAVFGAGEYTLKVGKKRFLKLKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSC7</accession>
    <name>D6SSC7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpC</name>
        <name evidence="15" type="ORF">Dthio_PD0928</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10 11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870943.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0928"/>
    <dbReference type="EnsemblBacteria" id="EFI33593">
        <property type="protein sequence ID" value="EFI33593"/>
        <property type="gene ID" value="Dthio_PD0928"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696893at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="SSF46604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="14">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="13">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI33593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="142" mass="15806" checksum="C0C6C071EF04FA16" modified="2010-08-10" version="1">MANLIRLEIVTPDRNLLSEDVEYVGAPGVSGEFGVLHNHTPFLTALSIGSLFYKKEGRKYFVFVSGGFTEVTPTKVSILAEVAEKADEISIERARKAKERAEQRLQQEKEQIDYARAKAAMARAMHRLRCRDDAVSAGTCSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSE3</accession>
    <name>D6SSE3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent Clp protease, ATP-binding subunit clpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870959.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0944"/>
    <dbReference type="EnsemblBacteria" id="EFI33609">
        <property type="protein sequence ID" value="EFI33609"/>
        <property type="gene ID" value="Dthio_PD0944"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013461">
        <property type="entry name" value="ClpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02639">
        <property type="entry name" value="ClpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="743" mass="83270" checksum="FA6B783A419384CE" modified="2010-08-10" version="1">MLSKELERIIARAIREVKVRHHEYLTLEHILYAYLMDDKGKEVLSDCGADLFKLKNQLERFFTDHMEVMPPSGDREVVQTIGVQRVMHKALSQIQSSGKNMIQAGDLLAAMFEEEEAFAVYYLQSQGLSRLDILEYISHGMEKDRPGSACSGCKPKEKNEKSALAQYTQDLVEKAGKKLIDPLVGREEELKRVIQVLLRRRKNNPIFVGDAGVGKTAMAEGLALQISQKKVPEPFFDTRIFALDMGALLAGTKFRGDFENRLKGVIKEIKEIPGAILFIDEIHTIVGAGATSGGSMDASNILKPVLASGEIRCIGSTTYEEFKNHFEKDKALSRRFQKIELPEPSTSESLEILKGLQPYYEEFHHVKYMPSALKAAVDLSARYINDRYLPDKAIDVLDEAGSIFVLSGSGKTKKQISPKDIEQVVSRMAKIPSRQISSSDKEKLFSLDQHLQDAIFGQDKAIQALTRAVKRSRAGLREENKTIGNFLLIGPTGVGKTELSRQMAQVMGVSFIRFDMSEYMEKHAVARLIGAPPGYVGFDQGGLLTESIRKNPYSILLLDEIEKAHPDMFNILLQIMDYATLTDNSGRKADFRHVTLLMTSNAGAREMSSPSIGFGQENQEDLTAKGVKAVENMFSPEFRNRLDAIIPFNALSKEVMQQVVDKSIRELNQQLKGKKVQVQLSAPAREWLAEKGYDPTFGARPLARLIQEQIKDPLAEKLLFGQNNKKSVVKVEHDKKNDQLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSG7</accession>
    <name>D6SSG7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870982.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0968"/>
    <dbReference type="EnsemblBacteria" id="EFI33633">
        <property type="protein sequence ID" value="EFI33633"/>
        <property type="gene ID" value="Dthio_PD0968"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="152"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="361" mass="40469" checksum="464AA682DC10CBA0" modified="2010-08-10" version="1">MNNHQDKKNIMIIDDTPANLKLLQEMLQGRGYRVMAFPQGEMALKAAARKPPDLILLDIRMPGLDGFQVCTRFKEQEGLKDIPVIFISALNDPSDKVQAFAAGGVDYVTKPFHPEEVHARVATHIRLRGLQKQVEDYNLHLEKQVEEKVREISESQLATIHAMSELVELRDVETGGHIARTSNLCKALAHQVSRESACASQVNSDFIDNISRAAPLHDIGKFGIPDSILLKPDKLTKEEFENMKSHCEIGGRTLQKALERYPKNTFLSMGVDIAWYHHEKWDGSGYPLGLSGESIPLSARIMALADVYDALRSSRPYKKAFSHQESLRIIQEGSGTHFDPELVQAFTAIEDRICSILTQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSQ9</accession>
    <name>D6SSQ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the mannose-6-phosphate isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871074.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1064"/>
    <dbReference type="EnsemblBacteria" id="EFI33725">
        <property type="protein sequence ID" value="EFI33725"/>
        <property type="gene ID" value="Dthio_PD1064"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006375">
        <property type="entry name" value="Man1P_GuaTrfase/Man6P_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01479">
        <property type="entry name" value="GMP_PMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="7">
        <location>
            <begin position="313"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="468" mass="52128" checksum="A03EDF1A1D08BF26" modified="2010-08-10" version="1">MFLPVILAGGSGTRLWPLSRKLYPKQFLAFGGELSMLQQSVRRLDGLQCAPPLLVCNEEHRFLAAEQMRLMGHEDVSILLEPEGRNTAPAIALAALHATSSGEDPVLFVMAADHHIHDQQAFQESVTMAAEQAGKDWLVTFGIVPDSPETGYGYIRRGENIQGQVYRAGRFVEKPDSDTAAAYLKAGDYYWNSGMFMFRAGRYLEELEKFEPAILECCRAAMQNARRDMHFVRVDKDAFNSCPGNSIDYAVMEKTQDAALVPMEAGWSDVGSWSSLWDLLPRDAEGNSCKGDVMAMDTSNSLLFSDYRMVATLGVQDLVVVETKDAVLVAHKNRAQDIKSLVDRIKSSGRSEHVTHREVFRPWGSYDGIDAGGRYQVKRITVKPGAKLSLQKHHHRAEHWVVVSGTAMVTNGEESFLVTENQSTYIPLGRQHSLENPGKIPLELIEVQSGAYLGEDDIVRFEDIYGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSY7</accession>
    <name>D6SSY7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="10">NN:DBI PRT</shortName>
            <ecNumber evidence="4 10">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobT</name>
        <name evidence="11" type="ORF">Dthio_PD1142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4 10"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871152.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1142"/>
    <dbReference type="EnsemblBacteria" id="EFI33803">
        <property type="protein sequence ID" value="EFI33803"/>
        <property type="gene ID" value="Dthio_PD1142"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="354" mass="36813" checksum="3CDE80F1253C5BEC" modified="2010-08-10" version="1">MTLLEQSIQHITQPDQEIKSAALKRLANQARPRGSLGRLEPAAARLASICGRLDVKLDRKTIVTCAGDHGVVEEGVSLFPSEVTAQMVYNFVQGGASINVLAAHAGARVRVADLGVSHDFDPGLDILHKKIRKGTANMATGPAMTREEAAASVEAGIGIANQLADSPGLDLLGTGDMGIGNTTASSAIIAVYSGLPLKELVGPGTGLDEQGLDLKARVIKRALDLNRPDPADPMGVLARVGGLEIGGLAGLVIGAAARQIPVVCDGLISTAGALIACELCPAAGQYIFAGHRSRETGHEYMLRHLGLTPLLDLEMRLGEGTGAALAMHILDACTRILADIKTFEEVGIENAHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST03</accession>
    <name>D6ST03_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871168.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1158"/>
    <dbReference type="EnsemblBacteria" id="EFI33819">
        <property type="protein sequence ID" value="EFI33819"/>
        <property type="gene ID" value="Dthio_PD1158"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="274" mass="30814" checksum="C9E326F6937A4A86" modified="2010-08-10" version="1">MGKNKNRPLPQEMALPPGGADSHAHLDFKTLAGNLDQVLDRAKKCGITTLGQVFLGPDAYLKGRELFSSQPGIFYILGVHPHEASTLDTETSGRLYSLARDDKRIKAVGETGLDFFYNKSSPQEQRQAFRTQLELARDLDLPAVIHSRDAAEETLEILKQMGFRDRKVLWHCFGQDLETARQILDHGWFISIPGSITFAKNTRLREIVREIPVDRLMLETDCPFIAPEPYRGKQNEPALMVFTALEAARSKDMDAGELWMTCGDNCRSFFGVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST19</accession>
    <name>D6ST19_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate dehydrogenase gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871184.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1174"/>
    <dbReference type="EnsemblBacteria" id="EFI33835">
        <property type="protein sequence ID" value="EFI33835"/>
        <property type="gene ID" value="Dthio_PD1174"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1612137at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="8"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="235" mass="26793" checksum="0575AA8D14516516" modified="2010-08-10" version="1">MQEKMIPRHDKGGIFIHWFNAVCWITLTLTGLGLINEHWNPLGGWYPAMMRTIFGSPEMLLNVHMYLGLFWAIVMIIYVLGRITESLAFAKEAFTLNPSRDMTWMVKKNIQLTMGDKMLKKLGMTTDIPPQGFYNAGQKLFAQISIIAGAILIVTGVIMFLSTMVLDNPTPVAWSRTIHYLFATLALAGLIVHIYMAAISREERPAFKSMFTGKVPESYAKHHHELWYNQIKDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST52</accession>
    <name>D6ST52_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TspO and MBR like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871217.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1207"/>
    <dbReference type="EnsemblBacteria" id="EFI33868">
        <property type="protein sequence ID" value="EFI33868"/>
        <property type="gene ID" value="Dthio_PD1207"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1679387at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="148" mass="16936" checksum="E792AE627903FD5A" modified="2010-08-10" version="1">MYSFIIFLALVLITSSFGAIFRPGPWYNELIKPALTPPGWIFTPVWMTLYLMIAIAGWLVWQKTRSIKHPAIVCWGCQIVLNALWSWLFFGLQSPALALVNIFLLLILILAFIRFSWPISRPASILFMPYALWVAFATYLNLGIVLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6STH4</accession>
    <name>D6STH4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component transcriptional regulator, LytTR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871339.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1329"/>
    <dbReference type="EnsemblBacteria" id="EFI33990">
        <property type="protein sequence ID" value="EFI33990"/>
        <property type="gene ID" value="Dthio_PD1329"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="181"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="287" mass="33222" checksum="16FEE2983464BDFD" modified="2010-08-10" version="1">MSTLKALIVHPDREVTLKLREFFAGEKRIKILGEAVSSNEALELLESISYDVFFLGIDLPDGVSGMELTQMLAQRKFRPHIVLIALDQQHAYKAFELGVADYLIWPFETGRLENTVDRLLRYTEMPHTAEKEVYDSQGSERSRDEGTVHLPMADADEDSFLNALRQAWDVSPRKQLEIEKLPINQEGKLLLVPYNQIVFVEAYEDYSFVHTFKEKFLTSYRLKSLEERLNKHGFFRVHRKYLVNLEMVTEIASMPGSNFMLRTAGKTKIELPISRRRINDLKQILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6STI8</accession>
    <name>D6STI8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">Dthio_PD1343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871353.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1343"/>
    <dbReference type="EnsemblBacteria" id="EFI34004">
        <property type="protein sequence ID" value="EFI34004"/>
        <property type="gene ID" value="Dthio_PD1343"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1940160at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8367" checksum="BD6BA27984A5B873" modified="2010-08-10" version="1">MKELIEYIAKSLVDNPDQVEVAEVEGEQTSVIELKVAKEDLGKVIGRQGRTARAMRTILGAASTKAQKRTVLEIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6STK4</accession>
    <name>D6STK4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1359"/>
    <dbReference type="EnsemblBacteria" id="EFI34020">
        <property type="protein sequence ID" value="EFI34020"/>
        <property type="gene ID" value="Dthio_PD1359"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031AFA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="34008" checksum="3B5CFC83B3F7D2BA" modified="2010-08-10" version="1">MNRKITLHIGMPKTGSTWLQHEILPKMKSIDVCYKEELRKCMLHWSNKNILISYENYVGFPHIKEADVQQGWIDSRKRSLCNLSSFFPDSDIILIVRKQTELLKSLYNQYIKVGGSISFHEYISGEHPYSININALKYIELLNQIQQKFSGSVLIVDYNFMKSHVEEFGKVFLSFVGCNDLIDFNKHSGRKVNTSLSNAQIKNMLRFNRQFHTYYSPNGYKMFRRKTYKKIRTIILRLTDFAYGNKQYDIFHKDDIEKLENFYDDDWRDTQQITKGRFKIINNKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6STQ0</accession>
    <name>D6STQ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dual specificity protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871415.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1405"/>
    <dbReference type="EnsemblBacteria" id="EFI34066">
        <property type="protein sequence ID" value="EFI34066"/>
        <property type="gene ID" value="Dthio_PD1405"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1145711at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="4">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="352" mass="40396" checksum="52F2B4B7D6F401EB" modified="2010-08-10" version="1">MQLWPFRKKQKKSSLVSWVTPYLAVGPAPMSHAHLQHLKQAGIDAILNLCAEFPDLPEIERRAGFDVYYLPVEDEETPDMETMDNALEWMDESIYLGKKVLVHCRHGIGRTGTLTAAYLLRKGLTSRKVNKLLNPLRSQPANYNQWSLLRQYGRLQGRLQIREPSLEQKNIVDLTPFFKDLEVLLNRVEINLEGRRLCGREHILCCSLDVRVSLVEAVYISHKINTVLTRESRQELIRKACGTNGTGEGDEPLECSLCPLNQNRKCSFFHHRPLACRLFDYSDLGSKEYADIMDQVGQLSRNLFLAFGGQFLQQDINFDLTRVISGKYVQDFFHILMQCAEGNNRISPEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STS6</accession>
    <name>D6STS6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871441.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1432"/>
    <dbReference type="EnsemblBacteria" id="EFI34092">
        <property type="protein sequence ID" value="EFI34092"/>
        <property type="gene ID" value="Dthio_PD1432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="68" mass="7646" checksum="E91021CF4AD150BA" modified="2010-08-10" version="1">MPKDFAKVVELYQPQEKDLRAKQDCQEQPSDNPYVDQSQLPLAIRCPQLGRLITSKDKDPGGGPQECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6STU9</accession>
    <name>D6STU9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, GSU0054</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871464.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1456"/>
    <dbReference type="EnsemblBacteria" id="EFI34115">
        <property type="protein sequence ID" value="EFI34115"/>
        <property type="gene ID" value="Dthio_PD1456"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAU8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1326452at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019089">
        <property type="entry name" value="Cas_GSU0054"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02165">
        <property type="entry name" value="cas5_6_GSU0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="478" mass="54804" checksum="7C9DF17A27303679" modified="2010-08-10" version="1">MLALEFTFPAGRYHANPWGRNVNEGEAEWPPSPYRLARALIDIQKRRFPDWEQARIESVLQGLSGKPFYLLPQATTAHIRTYQSSNEKDVTKKQLIFDSFVALDKGDSLYMAFENSMQEQHLVDLGTLLEELNYLGRSESWVKVNIRDNVPSFSWDCLPSDSAGQSSVYEDEKIACVLPRSEYESLPVSSDLSWFEAICLSTRDLLNQGWAHPPALEWIDYSRKKSRLNRTIPSRAGFESRREYRLFKYEIHSRVRPMVQESIHFAERIRLKLMGIHRKIQGDDPGLVSSKFSGKSADGSPLEGHGHAFFLPLDEDHDGRIDSLVITAREPFDSSELMALDRLRSIWQSNGKPDASLILSSMREQPNFKLSRTWVSATPFVTTRHHRKGRGSYLDWLTQEILLECEYHGLPEPASVNWIQWTITGPKPLRWMEFARGKRDERPFRGHGCIIHFNTAVPGPFALGARCHFGLGLFQPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6STW8</accession>
    <name>D6STW8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871483.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1476"/>
    <dbReference type="EnsemblBacteria" id="EFI34134">
        <property type="protein sequence ID" value="EFI34134"/>
        <property type="gene ID" value="Dthio_PD1476"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="344" mass="38343" checksum="66B7CC7584FAC554" modified="2010-08-10" version="1">MSFRRIGIWQTAFLGDAVLTLPLLQNLARAFPGAHMTYFVRKGLGPLFEPDPGLQVQEVDKYGRDSGPLGMIRTLASIRRQGFDLWVSPHTSFRSAAISAFSGIPTRIGYDSPRFNRAAYTHTCSRRFDQLEEIERVLQLLSPISVPALETWPGLHLHPLAREKAGEFRAKHTTGPVLGVHPGSTWATKKWPGAYFAEVIDMVHDNLDMQVMLFAGPGEEKAAREIKDLVRRQDLLLDLSGRLDLPGLAAFLQGLDCYLCNDSGPMHLAWTQNTPVAALFGPTTRSLGFFPRGEHSTVLETDLECRPCGLHGSKSCPQGHHRCMLDLTPKKVFDVIREKIHARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6STZ8</accession>
    <name>D6STZ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871511.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34164">
        <property type="protein sequence ID" value="EFI34164"/>
        <property type="gene ID" value="Dthio_PD1508"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="228" mass="27202" checksum="BAC39A5175728592" modified="2010-08-10" version="1">MSKIKQAHDKIFKNVFADRKNALNLLGNFLPANILNRLDLKQMVYEKDTFVQKQLKGYYSDLLVTIPLIDSDESVKVYFLFEHKSFSDPDLPLQLLRYIVEIWTHYRKQHKHVKLPLIIPLVVTHAEGSWKKARLSDVVDIPGEPFKAYLPDFEYLLFDCIQEDLNVYDLEVELKSLFMLWKYAHRPNFFEIVREVYRMLRQAYPEMEPRDFLIALAQYLYFTRGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU12</accession>
    <name>D6SU12_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module component, TIGR02574 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871795.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0418"/>
    <dbReference type="EnsemblBacteria" id="EFI33103">
        <property type="protein sequence ID" value="EFI33103"/>
        <property type="gene ID" value="Dthio_PD0418"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033AKF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2060697at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013406">
        <property type="entry name" value="CHP02574_addiction_mod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09720">
        <property type="entry name" value="Unstab_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02574">
        <property type="entry name" value="stabl_TIGR02574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8429" checksum="F44D547276C034ED" modified="2010-08-10" version="1">MSTITADILELSVAERLQLVEDIWDSIAAVPEAVPLNEDQKKELDRRLEAYHLDPEAGSPWIEVRERLRTRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU14</accession>
    <name>D6SU14_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0420"/>
    <dbReference type="EnsemblBacteria" id="EFI33105">
        <property type="protein sequence ID" value="EFI33105"/>
        <property type="gene ID" value="Dthio_PD0420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="46" mass="5746" checksum="D2643DE70ABEE990" modified="2010-08-10" version="1">MRGSVVEPLEIFWTEYMKYRVELRGYDFAMVEDILRYSPERYVDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU75</accession>
    <name>D6SU75_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871551.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0162"/>
    <dbReference type="EnsemblBacteria" id="EFI32855">
        <property type="protein sequence ID" value="EFI32855"/>
        <property type="gene ID" value="Dthio_PD0162"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="35644" checksum="606D934C447D2AAC" modified="2010-08-10" version="1">MPRIARFIRNDRQTVYHVISRTALPGLPIKDTDKDYLLGLIKRLSRLYFVDVLGFAVMGNHFHLVARMHPEDEISNSDIIKRWQDYYGDKVEMPTDRMAEVKKRLCSLGAYVKDIKQNFTRYYNKKHRRKGFFWGGRFKSMIVQEGSTLVNLLAYVDLNPIRAGIVKKPENYRWSSLGYHTQTGNKDGLLDIDFGLKEWNELDPKEIVRKYRQFVYETGAVDAGKGKTIEKKVVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDTRKFTPVGGVEGLYSMKRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU83</accession>
    <name>D6SU83_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871557.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0171"/>
    <dbReference type="EnsemblBacteria" id="EFI32863">
        <property type="protein sequence ID" value="EFI32863"/>
        <property type="gene ID" value="Dthio_PD0171"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50334QD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1820646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036782">
        <property type="entry name" value="NE0471-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143880">
        <property type="entry name" value="SSF143880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10248" checksum="8D9B8F4163675A5D" modified="2010-08-10" version="1">MNSIYLVEAKYVDNYRIFLKFNTGESGVVDLEDLIMKYKVAAPLQDPQKFSEFFLDSWPTLAWECGFDVAPESLYYRLTRNVAPGLKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUD1</accession>
    <name>D6SUD1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polar amino acid ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871604.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0225"/>
    <dbReference type="EnsemblBacteria" id="EFI32911">
        <property type="protein sequence ID" value="EFI32911"/>
        <property type="gene ID" value="Dthio_PD0225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="218" mass="23927" checksum="87C0E60C6587801C" modified="2010-08-10" version="1">MDFQYEFVLSTLPQLMQGVKLTIHITVYGLLGGMALGVLTGLILAYRIPVINYAGAIYVWIVRGTPIVVQAMFVYFALPLAMGIRMTGVYAAILVLAINAGAYIAEIVRGAVLSINKGYVDAGLALGLSRFQVTRYIVGPLAFRRMIPPLGNQFIIGLKDTSLFIVIGVGELTRQGQEIMASSFRALEVWTAVAIIYLVLTTVLALSLRWLERRMKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUK7</accession>
    <name>D6SUK7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ORF">Dthio_PD0301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0301"/>
    <dbReference type="EnsemblBacteria" id="EFI32987">
        <property type="protein sequence ID" value="EFI32987"/>
        <property type="gene ID" value="Dthio_PD0301"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="215" mass="23882" checksum="B6579A5A83DA5CBB" modified="2010-08-10" version="1">MRHRKSGRSLSRNWEHRKAMFRNMAKSLVTHEKIKTTLPKAKELSRVADRLVTLALRGDLSAKRQAYKVLGNHKLVKRLFDEIAPRFEKHSGGYTRVVKYAKPRVGDSASLALIEFTYKTSEGPEVTKAGLPKDKAQTKGAPAAAPAGPAASEPVPEKDSSITPEDQKQVEPEAQFPEAEDSTAADREADEQSQEDKSEESRPHDDPGEDPEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUM1</accession>
    <name>D6SUM1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">Dthio_PD0315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871694.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0315"/>
    <dbReference type="EnsemblBacteria" id="EFI33001">
        <property type="protein sequence ID" value="EFI33001"/>
        <property type="gene ID" value="Dthio_PD0315"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456375at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="179" mass="20205" checksum="DAA17BD6D9D8CC0A" modified="2010-08-10" version="1">MLRLEKYFKDEISPKLHKEFNYKSPMQIPSVKKVTLNMGLGEGSQNNKLIQDAVEELSRIAGQKAVVTRAKKSIAAFKLREGMPVGCTVTLRRARMWAFLDKLLNIALPRVRDFRGLPDRGMDGRGNYTLGIKEHTIFPEINLDKVDRNKGMNITVVTSANTDKEGKSLLTLLGMPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUT6</accession>
    <name>D6SUT6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.7" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871759.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0380"/>
    <dbReference type="EnsemblBacteria" id="EFI33066">
        <property type="protein sequence ID" value="EFI33066"/>
        <property type="gene ID" value="Dthio_PD0380"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="889365at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008789">
        <property type="term" value="F:altronate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GD_AH_C" evidence="3">
        <location>
            <begin position="3"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="387" mass="41874" checksum="BB0A779D8B0F93DA" modified="2010-08-10" version="1">MNIWGYMRPDGQVGIRNMVAVIPTVVCASETAKHIAERTRNTIYLPNQHGCCQLGNDMQLTTQTLINLGKNPNIAAVLVVGLGCEGVPIKKVADEIAAGSRKRVEHLIIQEQGGTLKTEEKGLRLVRDMIQETQSQHREQTDLSRIILALECGGSDATSGLVSNPVTGYVSDKLISLGGTTIFSETTEIIGAEHIFSRRAKSDEVKKKLLDTVAGCEQKARDLGFDMRGGQPTPGNIQGGLTTIEEKSLGCIYKGGKKQPLNGVLNYAQIPREKGLHFMDTPGQDIESITGMIAGGAQVVIFTTGRGTPTGSPIAPVIKITGNKTTYENMKDNIEFDASPVIDGRESIAQAGERLFQELIEVINGKQTKAEALGHREFGMYKLHSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUT9</accession>
    <name>D6SUT9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">Dthio_PD0383</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871762.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0383"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="EFI33069">
        <property type="protein sequence ID" value="EFI33069"/>
        <property type="gene ID" value="Dthio_PD0383"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="213" mass="23350" checksum="EB8B7ED1A4A9B53E" modified="2010-08-10" version="1">MKYTPMVIHSEGRNERSYDIFSRLLKDRIIFIGVPVDDQLANLVCAQLLFLESESSEMEINLYINSPGGSVTAGMAIYDSIQYISAPVATLCMGQASSMGALLLAAGQKGMRYALPHSRILIHQPLGGFQGQAADIDIHAREIIRIKQEINAIMAHHTGKDMATVEHDMDRDYFMGPAEAKEYGIIDHVLTTRAGLEGRQSQDKGRSARAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUV6</accession>
    <name>D6SUV6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871779.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0401"/>
    <dbReference type="EnsemblBacteria" id="EFI33086">
        <property type="protein sequence ID" value="EFI33086"/>
        <property type="gene ID" value="Dthio_PD0401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="99" mass="11353" checksum="C52E094FFEAF15E0" modified="2010-08-10" version="1">MNRFKNRVSKAGHARNPRNKDSLTARSHALAWSLKTQRSQRKAGRFFSFAGLAANEKAALSKTVSRFWTIDLLRVYNFAYLAALRFKGLPREARGYCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUZ0</accession>
    <name>D6SUZ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SapC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871840.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0034"/>
    <dbReference type="EnsemblBacteria" id="EFI32746">
        <property type="protein sequence ID" value="EFI32746"/>
        <property type="gene ID" value="Dthio_PD0034"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ZZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1512520at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010836">
        <property type="entry name" value="SapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07277">
        <property type="entry name" value="SapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="177" mass="19650" checksum="DA7765BB96620469" modified="2010-08-10" version="1">MPNWIALSPSQHANKHYLPRQGYSFAADQQAVPILLAELSKLLPHYPLAFIQQENTYQPVALTGLGGGQNLYVNHDGKWLATYVPAFLRSHPFRLLTAENKQQVLCIQEDHLVDDSQGQPLFDQEGNLTKPVQDTLNFLNECEKNRRVTLAACAALDNGLGLWVCLGLGSDLIKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUZ9</accession>
    <name>D6SUZ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871849.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32755">
        <property type="protein sequence ID" value="EFI32755"/>
        <property type="gene ID" value="Dthio_PD0044"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1767996at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_ParB" evidence="2">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="351" mass="40875" checksum="81DC1EE361C72F47" modified="2010-08-10" version="1">MSTEVSQLNPLLIISENPEAKELDQRLNCMVTEAIPEGMDERAKANRFIVWIEQKDTGEHDALIYYGTDEEKNLTAKKEYAETLQNALKLNADIVQEEEPNLLAQWHRDNRPQTKSKHAIKLETKEFDLDILTTALSDTFGIQEQEEDQQLVKEAYEEVYNIMNSHFSKAVEDVGQYLIEKFYNNNIDRARKNKPVKQKSLRALIQSLEHNNYSQAWFYNAVKIALDKKELEGTHYNQLSVSHRRALTKVKNTQQKAKLAEEVVNNDLSVRALEEKVKKQKTEKEGFSLKKLPNKNKLKLKRLDELESIKTKIEHRINSLETKIEKFREEKKNYNNNLKKVEALISEKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV20</accession>
    <name>D6SV20_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0069"/>
    <dbReference type="EnsemblBacteria" id="EFI32776">
        <property type="protein sequence ID" value="EFI32776"/>
        <property type="gene ID" value="Dthio_PD0069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="47" mass="5143" checksum="8CFCC218B262D2B8" modified="2010-08-10" version="1">MKCKLKRLKVVVGATALSRNETTLGLSHLCYPKNIHLQTKSQGGGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJR8</accession>
    <name>D6SJR8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869246.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3574"/>
    <dbReference type="EnsemblBacteria" id="EFI36121">
        <property type="protein sequence ID" value="EFI36121"/>
        <property type="gene ID" value="Dthio_PD3574"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="148"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="233" mass="26198" checksum="4D26ED13F89ACB46" modified="2010-08-10" version="1">MVENGGLQQEQGIKEARELAKAYESIAGRMNGFMFRCRNDEQYTMLVLVGMVEMITGYAQKDLLYNRKTSYVSLIHPDDVPKVDTAIEKGIKARKNWAVDYRIICFNGKEMWVNEHGGAVYNQEGQVEYLEGVVVDISDRLQEIERRKSMEQVGELSKKIIKETKNILHLLQALKTLGLNARLEAGRAGEAGKGFSVIADQVKELAKETGTSAQSINDLIAELEKRLKDASEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJU0</accession>
    <name>D6SJU0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869268.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3597"/>
    <dbReference type="EnsemblBacteria" id="EFI36143">
        <property type="protein sequence ID" value="EFI36143"/>
        <property type="gene ID" value="Dthio_PD3597"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2170543at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10281" checksum="9E4BFD2F19333282" modified="2010-08-10" version="1">MRTPFDPLKFLQSLRLNVELDSKGQVTVHGIRFLEPHKAQQARNVLQIYDKLLRMQLDAPSKTMRPSVRKLLALGKVEIRDGQYTIPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK09</accession>
    <name>D6SK09_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869334.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3669"/>
    <dbReference type="EnsemblBacteria" id="EFI36212">
        <property type="protein sequence ID" value="EFI36212"/>
        <property type="gene ID" value="Dthio_PD3669"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337H4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1806294at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="111" mass="12997" checksum="0985BB4B6E736097" modified="2010-08-10" version="1">MRSYMIQDIRPQDMDTFTAHLKETGYKSPMDGIFWIPLPESLQGKAQQEHNSQCGPYYLALEVGQDWLRLELLVRSEQRLRCDCIMYADPGQREAMIEFLDDLIKNRDIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK93</accession>
    <name>D6SK93_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869415.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3759"/>
    <dbReference type="EnsemblBacteria" id="EFI36296">
        <property type="protein sequence ID" value="EFI36296"/>
        <property type="gene ID" value="Dthio_PD3759"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1956590at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038756">
        <property type="entry name" value="CheX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39452">
        <property type="entry name" value="PTHR39452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="46"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="158" mass="16592" checksum="0EC624BB52798692" modified="2010-08-10" version="1">MDQKVQKVIKTFVGSVINVLGTMAMVDAKPGKAYVKKDNTARGDISGVIGFSSPNGKNKGTMSVSFTQSSVLGIINNMLGENYKEVTNEVTDAVGELTNMISGQARKGLAEIGMQFEGAIPTVVTGKDHSIRHVSSSAILAIPFDTDGGPLTVEICIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKE9</accession>
    <name>D6SKE9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnA</name>
        <name evidence="3" type="ORF">Dthio_PD3820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3820"/>
    <dbReference type="EnsemblBacteria" id="EFI36352">
        <property type="protein sequence ID" value="EFI36352"/>
        <property type="gene ID" value="Dthio_PD3820"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="336" mass="36717" checksum="1DA7E980A304A4FE" modified="2010-08-10" version="1">MQHVYFDEKQSVLMLLDQRYLPDSEQWFKCAGTQDIVYALQQMVIRGAPAIGVTAAYGCVLAALEARGSSNWEEDLEKSLQTIEHARPTAANLAWAVRGMRHAWRSGSFFSPAQLAEFWLPEALHVHEEDIRINKMIGAHGRDLIFSGDTVMTHCNAGALATGGYGTALGVVRSAVEQGKDIRVIANETRPFLQGARLTAYELARDNIPVRVACDNACGLLMHKGLVHKVVVGADRIAANGDTANKIGTYTVAVMARRHGIPFYVAAPFSTFDVQTSSGEDIPIEQRDPAEVKCMTGQMIVPPDVQVYNYAFDVTPHELITGIITEKGVFAPGEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKG9</accession>
    <name>D6SKG9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869488.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3843"/>
    <dbReference type="EnsemblBacteria" id="EFI36372">
        <property type="protein sequence ID" value="EFI36372"/>
        <property type="gene ID" value="Dthio_PD3843"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1994547at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10408" checksum="42F402022A93913E" modified="2010-08-10" version="1">MSIDFLVHEKGDGVGVVVVEGLKAGQEITGWIMKEDQTIKTKIVSDIPIGHKLALQDFNAGDTVYKYSTDIGKVVAPIKKGEHLHVHNVKTKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKH3</accession>
    <name>D6SKH3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP dicarboxylate transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3848"/>
    <dbReference type="EnsemblBacteria" id="EFI36376">
        <property type="protein sequence ID" value="EFI36376"/>
        <property type="gene ID" value="Dthio_PD3848"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="18"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="442" mass="47064" checksum="56E2897B7B0F2685" modified="2010-08-10" version="1">MEVSIFTLEISILTMVLLSLGAMFLLGMPVFMSLAVASALALSYGGYLPMSVIHNTMFDGLNIFPLLAIPCFVIAGTLMEYGNITKQIVDVVKQLVGRMYGGLGLTTIVACTFFAAISGSGPGTVAAVGTILVPAMIRTGYSKDYAASVASSGGTIGLLIPPSNPMIIYAILGNVSVTAMFTAGFLPGFIVGFSMCMTAWLIARQKGFGRSEELPPFNLRHFLLSCVKGFFSLITPIIILGSIYTGLATPVEASVLAIAWALFVGFLINRALTLSAVYKSLLEGSLICGAVLLIVGTSTLFGRILTFEEAPQLLAEMALSVSENPYIILLMIVGVLLILGMFMETLSTIIILVPVFMPMIHIIGIDPVHFGIILVLTNQIALSTPPLGVNLFVASRISKVSVERISIGVLPYIIAMLICTLLIVFFPKISTILPELILGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKV9</accession>
    <name>D6SKV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35320">
        <property type="protein sequence ID" value="EFI35320"/>
        <property type="gene ID" value="Dthio_PD2735"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2162682at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022472">
        <property type="entry name" value="VPLPA-CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03370">
        <property type="entry name" value="VPLPA-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="20898" checksum="4E9DE858FBBCB4A7" modified="2010-08-10" version="1">MVSILKKVTTGWVLGIFCVFLFPLAVHAGKINFYQLGVSGGASPYYQGVLSEDLTLTITNNKEGSLLSHFYFYGLGDIKVADVDGFKNPATPGFLPGLYSPPVTPDRSFGFSSPAYRVAAGDQIAFALSDGNYEDVFSLIRNNDLIIGLFVQDFDGSESAQFASVPLPASVVLLFSGLAGLVFFRRFKKDEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL46</accession>
    <name>D6SL46_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868539.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2823"/>
    <dbReference type="EnsemblBacteria" id="EFI35407">
        <property type="protein sequence ID" value="EFI35407"/>
        <property type="gene ID" value="Dthio_PD2823"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="PTHR23264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="6">
        <location>
            <begin position="324"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="426" mass="45887" checksum="B22B50DD33C491A7" modified="2010-08-10" version="1">MSDKACGSCSTASDCQSRSKEQEKNRKLAHSLSRIKHKVVVLSGKGGVGKSSVAANVAAELSLSGCRVGLVDVDVHGPSIPRLFGLEDSRPVTRDQKLVPAMWNGQLLVMSLGFLLQSKEDSVIWRGPVKMGLIRQFLEDVDWGDLDYLIVDCPPGTGDEPLSVVQLLGHEAHALIVTSPQDVAVDDVRRSVNFCRHTGNQVLGIVENMSGFVCPRCGEEAHIFSSGGGQKLAQEMQVPFLGGIPLDPDMVKAADEGMPFIARQAESPALSALQKILEPIKQLQGQKDFFQDQLSNLQASPSNTPDSVRPQNGAVKIAIPLAQGRLCQHFGHCELFALFSVNTEDKTILHQEQLTPPPHEPGVLPNWLAEKEAGLVIAGGMGSRAQDLLREKGIRIITGAPEGTAEEIVKSWLDGNLVTGQNACDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL75</accession>
    <name>D6SL75_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0751 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868568.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2856"/>
    <dbReference type="EnsemblBacteria" id="EFI35436">
        <property type="protein sequence ID" value="EFI35436"/>
        <property type="gene ID" value="Dthio_PD2856"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1959295at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016772">
        <property type="entry name" value="UCP020408"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10087">
        <property type="entry name" value="DUF2325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="99" mass="10930" checksum="091B9370D83977CE" modified="2010-08-10" version="1">MTAAVIGGMDRLQPHYQKTARKAGYKIKMFTGTENTITERLGSIDLMIIFTNKVSHSARKNAFEAARSENIPVIMCHSCGVSTLRDCLNNPKPDCPMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL89</accession>
    <name>D6SL89_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ion transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868582.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2870"/>
    <dbReference type="EnsemblBacteria" id="EFI35450">
        <property type="protein sequence ID" value="EFI35450"/>
        <property type="gene ID" value="Dthio_PD2870"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7ZD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1280139at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="PTHR10037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="6">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="271" mass="30381" checksum="F0763F2936E2C2F1" modified="2010-08-10" version="1">MQQEIHKPEGLQSRALALVENQKFQRLVIAVIILNGIVLGLETSDRIMSLAGPVLLTIDKLCLGFFVVELLIKMYAQRRQFPRDGWNVFDFLVVAVSLVPEQAGLAVLRSLRVLRVMRMISALPSMRRVVGAMLHALPGVSSVAGIIAIVFYVGAVMSTKLFGQEFPDMFGSIGASLYTLFQVMTLEGWSEDVVRPVMEVYPHAWLFFVPFILVTTYTVINLVVGIIVGAMEDRAIEEGSKQDPAVVLTRLEKRLDDMDSKMEELLREKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL98</accession>
    <name>D6SL98_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868591.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2879"/>
    <dbReference type="EnsemblBacteria" id="EFI35459">
        <property type="protein sequence ID" value="EFI35459"/>
        <property type="gene ID" value="Dthio_PD2879"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="186" mass="21668" checksum="0C28F7E347BC7FD4" modified="2010-08-10" version="1">MGEAHPVQPMTAAEYLDWEPAQLEKYQYIHGEVFAMGGASRRHVTITLNLASSLDQALEGSPCRVYMADMKLEIKKEEIYFYPDVLVTCDPEDHKAEQFMRSPVVVGEVLSESTAAFDRGDKATYYRSLPSLKEFVLIDPERRRMELYRRTQQDTWELLDIPPEHHLPLHSLELEIPWQRIFRNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLD7</accession>
    <name>D6SLD7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; Fe-Mo cofactor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NifD/NifK/NifE/NifN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868630.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2921"/>
    <dbReference type="EnsemblBacteria" id="EFI35498">
        <property type="protein sequence ID" value="EFI35498"/>
        <property type="gene ID" value="Dthio_PD2921"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="363662at2"/>
    <dbReference type="UniPathway" id="UPA00782"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000318">
        <property type="entry name" value="Nase_comp1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005973">
        <property type="entry name" value="NifE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01283">
        <property type="entry name" value="nifE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00699">
        <property type="entry name" value="NITROGENASE_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00090">
        <property type="entry name" value="NITROGENASE_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="7">
        <location>
            <begin position="39"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="459" mass="51078" checksum="67C9FEC514E802FA" modified="2010-08-10" version="1">MQPGLLKDRQKQVYQKGTTPFDLDCNKGSLAGAVSQRACVFCGSRVVLYPIADALHLVHGPVGCAAYTWDIRGSLSSGPELYRLSFTTDLQEKDVIFGGEKKLYQALVELIERHDPRAAFVYSTCIVGLIGDDLAGVCKKVSREKDIPVIPVQSEGFKGNKRAGYQAACKAMFELVGSADTSDISPVAVNILGDFNLAGETWIIRDYYRRMGVEVVANITGDGRVDDIRRCHGASLNLVQCSGATVELARMMQEKYGIPYKQVSYFGMEDMARALYETADFFQDKDPGIAARTQEIVRRELQAIHPEVQKYRWDLEGRKAAIYVGGAFKAFSLIKCFRHLGMQVEIVGSQTGTKEEYQEMADMCHEGTIIVDDTNPSELARFIKEKDVDILVGGIKERPIAYKLGIGFCDHNHERKLALEGFEGMVNFAREVHSTVMSPVWNFVPRRAGGMTNHKNMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLG4</accession>
    <name>D6SLG4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyrrolo-quinoline quinone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868657.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2949"/>
    <dbReference type="EnsemblBacteria" id="EFI35525">
        <property type="protein sequence ID" value="EFI35525"/>
        <property type="gene ID" value="Dthio_PD2949"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="560"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="661"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="799"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="891"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="924"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="957"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="1631"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1670" mass="182045" checksum="7059FF2E578C218C" modified="2010-08-10" version="1">MKNLNFYKKMFLSFFFCFWAFILCLSGPEKSIARETAANKQQELQDLAVQGELTVRAMRAWGMLPERFMHLALELRSQGINLLDADMQTLSELLDRAVEDELLNAFAHPLEELAEYMHEFVLAAQSFETKAGINDVQKTAKKESLSVSQQQNMARTLFARIDALDDDELDEMEKLYHQVMQKAPDTGYAQESYWRLSNMYMRAYSPSRNLDAIDILETYVQRYPGSTFLDDQFAMFATPGMPTAKKRLLYLYETEELWSEAADLYGQLIVDLDASGQDLLEHYISYGRVLENLDRNEEAVAVYKAYLQNTEKDSRTLQNAARTRLSALGAEVPETRVRVSFDNLFDAAQAGSLAEVKRLVQEGADVTSRRIVGAPRYGRASEENPIGPGDMGTESIDPLHFAVAKGHIEVVKYLLEQGADPGSAGEQNWRLPLMLAAENSDLEVAMVLLDAGADVDATGRGGAAALHFAALMADSDFVQVLIDAGASIDKKCRRGQLPLHYAAGNPAKNVAEMLIEAGSELEARDNAQRTALHLAVVSNNLAVGELLISSGSDTGAAMSSGDTALHMAATLEDNARPWVEMLLEEGADVLATNNDGAHPFDYAVRYSQPFVMESLFVEGIDLDQEFVQQMTYLHSAVLQNRYAVAEKLLQLGANADAVNYLQMTPLMLAAQHGSKESAAVLLKYDADISLVDGQHRTALQLAIGYREAPVVSLLLENGADPEYSHHENLTALLQILNHYYAEADEVKTITEVLLAAGADTNVKDGRGNTPLHLAAGKGNTQMVKQLLEKGLKVDEPGPGELTPLHLAAQGGHLDIVELLVQSGADIQVQNRRGNTAMELAHSNGHSEVVLMLEKSGASLHGDLLQAAAQGDAQDIKRHIDSGADVNAVDDDQNTALHLAIAAGHKDAAETLLKAGANVNALNKRHETPLHKAAMTGEEDLLEILLENGAEIEVPDRHGFTALHVAVVFGNTGIADKLLELGAELQAQQIGLELMFEAVYQGQIPGLEYLLEHGVSINAQDEDGWSVLHVAAYEVGNPETVEYLINRGADIDLEDAQGHTPLDLVGEIISHEIYLNIAEMLIAHGAKADPRVMGWPELRIAAVRGEVDQVRQVLADSPEQLTEDEDWAWPILHSAARAGRADVLEILIESGADLEYSIGWGAHYTPLVSAAMEGKRDAVQVLLQKGADPDPLQRILLSAIGHNRDMEILTKFAAAGVDLDAGSDSWDPPLFQARDQEMLQHLLDLGADVNVRNLHGETRLNVAVADKKSELTGLLLQYGADPDLQDHDGNTPLHSAVDEGNVAMAALLLENGASADVTNDEGLTPLQVVEENTWISNRSELLDLLAALLPTADLVWKFGTGGPVDSSARYSNGHIFIAGQDNYLYSLDQATGSKIWSFKTADTIFSSPAVVEGVVYTGSLDGFLYAVHQETGEEKWRFNADKDIVSSPYHWEGSAFISNLQGDVFAVDAETGDKIWKFESGSRSISSAVILDGVVYFGSGDGELIALDGKNGEKLWSFETEAEILSSPALTEDMVVVGDWQGNVYALDAESGQELWSTQAGRDLLTVPVIARDRIYVGSLEGYMYALDLHTGKEIWKFDSGGGIQSSPAMAGNTLYFGDSKGILYALDSESGREKWRFSALATIISSPLILNDIVYFGSYDGHVYAVSYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLP7</accession>
    <name>D6SLP7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868737.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3037"/>
    <dbReference type="EnsemblBacteria" id="EFI35608">
        <property type="protein sequence ID" value="EFI35608"/>
        <property type="gene ID" value="Dthio_PD3037"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="6">
        <location>
            <begin position="710"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="706"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="796" mass="87630" checksum="C98ED26FF8BE30A5" modified="2010-08-10" version="1">MSLVINTNMMAMNAARNLDHHYGDLATSTRRLSSGLRIDTAADDAAGLAIRELMRADIAAMNQGVRNANDGISAIQTADGALEVIDNKLIRMKELAEQAATGTYTTDQREIIDQEYQQMKAEINRIANATEFNQVKLLDGTLGEEDGNPMKLHFGPRNNDGEDFYYVNMGDATARGLDIGNSYLQSNLEERLIENQNSLKAINSQINREKPDNPEELMEEIDDIKYYLEGMRDDLLRAYEEEEVTEEFSELKDSLENAINQLEQAQDEYENPDNEEPDWQNIDENISSAYSFLNGKERAVEGLAGALTGEVSSGKVYHATVDGETFEYEAGSGDTASDVVQGLASLIDQSDDYEAEVKNGDLVVYGASQVGAFELVEGSGNTALDVSSGNGDTTLKFGGPEPEVGMIYNLEIVSGDINETVEYVAREGDTLQDVMQGLTQNINEQTGLDATYIDLEDGEIKIEGQEFDDSDITFYHSESLIYEERKISSISDQLYNIDSGQTYHININGEAFTYTTEGNDNSGDVIDGLVEAINESDIYSARYIDDEIIINGAASSDIMVYELSSGNDVVKTTSNEEDNELQIKIDSGPLWEGAVYAIDVEASGGDTERYEYIVQEGDDHDDVMKALAESIDLDNHVQGASFDEHKGIVIQEEGIEGDDATIFASTRLEGDIEINNPSAQIGEPNIQEDAERFDSHVNDTKPTMFAQNALEEIDAAIEKKDRIRADLGAFQNRLESTISNLQIQAENLQAAESRISDADVAYEMTQFMRNQVLSQGATAMLAQANTLPQMAMQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLS2</accession>
    <name>D6SLS2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35633">
        <property type="protein sequence ID" value="EFI35633"/>
        <property type="gene ID" value="Dthio_PD3062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="41" mass="4828" checksum="154BD0F8A9FA4A39" modified="2010-08-10" version="1">MKFSPIQVIVPVKITKPSKLLIWRLYQCLQVDDIGFQGNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLU5</accession>
    <name>D6SLU5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ORF">Dthio_PD3085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868785.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3085"/>
    <dbReference type="EnsemblBacteria" id="EFI35656">
        <property type="protein sequence ID" value="EFI35656"/>
        <property type="gene ID" value="Dthio_PD3085"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="166"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="313" mass="35861" checksum="C50F17DA5D94DE5F" modified="2010-08-10" version="1">MSKDNADRLPRIICILGPTGSGKNRLALELSGFFPVQIINFDSRQVYQGLPIITAQPGKHELEVCAHHLYGFLSPDKSISAGRFVQMARECIQGVRRESGIPVLVGGTGLYLRSLIHGLAEIPPVGDDVRRALQLRCMHEGPEILHRELQEIDPEYAARISCRDRQRITRALEVYQDTGFNMTAWHRSQPSGPFFRVLKLGVYTQWEYLEQGLHRRIQDMLRAGAVEEVQEVCRVYGFNRDLPAMTGIGCREVMDFLAGDTDMKSCIQRWFKNTRDYAKRQMTWFRKESDVHWIQAGDFSEARGMVEKFVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLV7</accession>
    <name>D6SLV7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DivIVA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868797.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3097"/>
    <dbReference type="EnsemblBacteria" id="EFI35668">
        <property type="protein sequence ID" value="EFI35668"/>
        <property type="gene ID" value="Dthio_PD3097"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="875822at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="36"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="166" mass="19486" checksum="1A3FEB6AFD548FDE" modified="2010-08-10" version="1">MDISKIDILNKKFSTSLFGYKKNDVEMFLQEVADYVGELAEKKSQLDQEIKHLEEKLQEHRSREEVLQNTLLTTQKMTDDIKANANKQAKVIVQEAQSKAEDILRQAHKRLAQIHEDISELKKQRAHFEIKLRSMIESHLKLLESHDEEHLHLEEAESKLKFLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLZ8</accession>
    <name>D6SLZ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868838.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3138"/>
    <dbReference type="EnsemblBacteria" id="EFI35709">
        <property type="protein sequence ID" value="EFI35709"/>
        <property type="gene ID" value="Dthio_PD3138"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10515" checksum="9B5C874A534395CB" modified="2010-08-10" version="1">MNKSELIKRLAEERDLSLEEATEIVTIFFDSMKEALQNGDRVEIRGFGSFKIKEYDGYQGRNPKTGKPVNVSPKRLPFFRAGKELKEYLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM05</accession>
    <name>D6SM05_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868845.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3145"/>
    <dbReference type="EnsemblBacteria" id="EFI35716">
        <property type="protein sequence ID" value="EFI35716"/>
        <property type="gene ID" value="Dthio_PD3145"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZDQR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2033866at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8474" checksum="FE499F59BFE45A74" modified="2010-08-10" version="1">MAYFLRNPDNYPLEEQVKILGDEELLDFWEESQFLDRFNDDEAYKTPGPRINYEEVILKELQIRTCMKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM48</accession>
    <name>D6SM48_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3189"/>
    <dbReference type="EnsemblBacteria" id="EFI35759">
        <property type="protein sequence ID" value="EFI35759"/>
        <property type="gene ID" value="Dthio_PD3189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="31" mass="3918" checksum="E34EC0BDC8334B8B" modified="2010-08-10" version="1">MYVGNKFKRLNLTDPYRESRDRHSSNYYYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM54</accession>
    <name>D6SM54_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35765">
        <property type="protein sequence ID" value="EFI35765"/>
        <property type="gene ID" value="Dthio_PD3196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9108" checksum="11A6C53D140F0AA0" modified="2010-08-10" version="1">MSTRKIVPVHHKTLIRLFELEGFTVKRQRGDHIIMTKPGINRPLVIKTSPGNVPTTHIRTNLTTAGISRTRYFELLDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMD8</accession>
    <name>D6SMD8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3287"/>
    <dbReference type="EnsemblBacteria" id="EFI35849">
        <property type="protein sequence ID" value="EFI35849"/>
        <property type="gene ID" value="Dthio_PD3287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="100" mass="12009" checksum="5D2D9D8611349717" modified="2010-08-10" version="1">MYYMLEKVTGFDWDEGNFDKNLIKHDVQNWECEQVFFNKPLIILDDHRHSLVEKRLAAFGKTDGGRLLTMIFTIRKSLIRVISARDMNKKERIYYHEKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SML6</accession>
    <name>D6SML6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3369"/>
    <dbReference type="EnsemblBacteria" id="EFI35927">
        <property type="protein sequence ID" value="EFI35927"/>
        <property type="gene ID" value="Dthio_PD3369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="8105" checksum="5E7275DD1F178E3D" modified="2010-08-10" version="1">MLNMDSNSYIIPYLNPCQTYFNTSKRDFLFRLQDLAHIPERDVTTTKCKIPSLLPTPREVFLCFIAYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMN2</accession>
    <name>D6SMN2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3385"/>
    <dbReference type="EnsemblBacteria" id="EFI35943">
        <property type="protein sequence ID" value="EFI35943"/>
        <property type="gene ID" value="Dthio_PD3385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="33"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="376" mass="41521" checksum="07F64E20862617D5" modified="2010-08-10" version="1">MQSPFPELQLFITGPIYVRPEVRQAGLWPEFGHRDAENRKRFEPIMKNLKILAGAPDDYEVIIFNGSGTNAMEASIRSLVADGEKVLNVSVGAFGDLYHKIATVNGKDAVQLKFDPGSCIDTARLQQALDEHRPAVVSLTHNETSTGVTNDIKAACEVIRRSGALALVDGISIFGGSPSHIEDTRCAMYITSTQKSLGLPAGFGIAFVSPEALAKAEKVSNRGFVSDILAQLPRARKFQTLTTPNCTLANQMYLQMEYIVNEEGVESRFKRHLQMRDAVHEFVSGLEGFELFAPEGYRSPTVTCVRVPESMTAARLKEIKETLREKGYLFDPGYGKLNDALEQAGKRAVFRIGHMGDMNMDMLEEYLQTLKGILQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMP3</accession>
    <name>D6SMP3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869082.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3396"/>
    <dbReference type="MEROPS" id="M23.009"/>
    <dbReference type="EnsemblBacteria" id="EFI35954">
        <property type="protein sequence ID" value="EFI35954"/>
        <property type="gene ID" value="Dthio_PD3396"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="200"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="34467" checksum="89F225A518967700" modified="2010-08-10" version="1">MLFKKYQLVIFKDKHGSCSSITLRGWVFMFALLLILAVAGTNVYLWKHYQEYRTVSQQLNRSQDTVQSQKIQLTTLFHKFHDLEQNLERVQEFDDKLRVMLNLEPPRELNPNPIGGTSENTSPSSFPFYRQEMLTRQMHNFLDQLSKEARLEEIKQQEILQALHQQKDLLSSTPSIWPAQGWVSSDFGYRSSPFTGQREFHKGLDISAPEGTPIYAPASGKVTFTGRDGGYGITMVIDHGRGITTRYAHLQRYVADEETKVSRGELIGYVGNTGRSTGPHLHYEVRLNNMPVNPKRYILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMT7</accession>
    <name>D6SMT7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ORF">Dthio_PD3440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869126.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3440"/>
    <dbReference type="EnsemblBacteria" id="EFI35998">
        <property type="protein sequence ID" value="EFI35998"/>
        <property type="gene ID" value="Dthio_PD3440"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="263" mass="29456" checksum="4E2ED28C099C7D10" modified="2010-08-10" version="1">MLQHPNFDPVAIAIGPLEIRWYGLMYLAGFTLAWLLARHRAKKPGSGWDVKELPDMVVFGALGIILGARLGYMLFYDFFGLISQPWTAVMIWQGGMSFHGGLIGGIIAMYWYARKTGRGFFTVTDFVAPMGALGVMCGRIGNFINAELWGRPTDVPWAMVFPGSDMVPRHPSQIYQALLEGLLLFIILWIFSSRPRPTMAVSGLFCLGYGVLRFLVEFFREPDAHLGFVLLDWMTMGQILSVPMIILGAVLLYLAYGFRGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMX7</accession>
    <name>D6SMX7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3481"/>
    <dbReference type="EnsemblBacteria" id="EFI36038">
        <property type="protein sequence ID" value="EFI36038"/>
        <property type="gene ID" value="Dthio_PD3481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="45" mass="5274" checksum="9AEA24184BDEC0C6" modified="2010-08-10" version="1">MGCDCQKCEFPQKLKDRPEDCTPEQIRECHGESREQETESKNQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNF7</accession>
    <name>D6SNF7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GYD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869611.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1634"/>
    <dbReference type="EnsemblBacteria" id="EFI34283">
        <property type="protein sequence ID" value="EFI34283"/>
        <property type="gene ID" value="Dthio_PD1634"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1774162at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014845">
        <property type="entry name" value="GYD/TTHA1554"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08734">
        <property type="entry name" value="GYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10618" checksum="8149BBE7B67CC3C4" modified="2010-08-10" version="1">MPEYVVLSKLTDEGRKTLKKKPERIMEVNKELEDMGVKVKQQYALLGNYDFLNIVEAPDNEAMMKMSVELGSRGSVELLTLPALEIDAFVKQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNK9</accession>
    <name>D6SNK9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M1 membrane alanine aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869663.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1686"/>
    <dbReference type="EnsemblBacteria" id="EFI34335">
        <property type="protein sequence ID" value="EFI34335"/>
        <property type="gene ID" value="Dthio_PD1686"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="1">
        <location>
            <begin position="292"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="692" mass="78411" checksum="BCC94C1AD3FC883C" modified="2010-08-10" version="1">MQKIILTTTAVLLGFVMILAGSPAMGADRHVHHELEITLVPQEQKLEGRARVSLPEAERKQRLHLSPQARVASVRLNGQKLEHSFSRSVLEVELPREAAGSRATLQIDYEAEFDDETPGPAMHTEDPTYGVAGAITTEGTFLSGGSGWYPDPRQGPATWDLRVQAPAGYLAVTAGRLKEHTTGEDYSLSKWQVDVPLPSLTVSAGPYEVKTDDSGDVPVSTYFYPESQDLAHDYLQAARSHMDFFQAILGPYPFEKFAVVENFFPTGYGLPSWTLLGSRVIRLPFILETSLPHEIAHSWWGNGVRVDYSQGNWSEAVTTYVADYLLLERESEEEAQQYRERLVRGFSSLVSQDNDFPLEEFTRRDSRESQAIGYGKGAMVFHMLRSEVGEQEFWEGLRRMVREYMFESAGWSDFARVFSEVADKDLKPFFEQWVQRSGAPFISLDDVDVSGLPGRWTISGTIRQEEPVFDLHLPVHIETPTRRLVHKLHLDGRETTFEFQARSRPSKFMVDPYSDVFRRLHPEEMPATVERIRGSRDLNAVAAQGMSEQELEAARMLLQTLNRQDVSVISEDEAGDKDLLGRDVLFLGMPEKELARENFEQAGKASMQQGRSFFEQKSLDDPENALFMAVNPGQDPETVWAYFMFGSEEAARDAVRRIGHYGSDSYLLFRDGENRARGTWEEMDLPLQYDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNL1</accession>
    <name>D6SNL1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869665.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1688"/>
    <dbReference type="EnsemblBacteria" id="EFI34337">
        <property type="protein sequence ID" value="EFI34337"/>
        <property type="gene ID" value="Dthio_PD1688"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1985749at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="9008" checksum="ABE3FFF4F3468AD9" modified="2010-08-10" version="1">MPRLYPTSWRTQLKIFEIFGCTYIRKKGSHHILRCPKAKRAVVIPEYDEIDIDIIKSNMQTAGMSRETYFELMARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNQ8</accession>
    <name>D6SNQ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1736"/>
    <dbReference type="EnsemblBacteria" id="EFI34384">
        <property type="protein sequence ID" value="EFI34384"/>
        <property type="gene ID" value="Dthio_PD1736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8124" checksum="A696DB2F7E09EBC6" modified="2010-08-10" version="1">MLRQDRLKRVAIGAGRIFDFAGSYDLDVCNKFLRTDSDTLDHDAVRSDWDQVGNDLKEALSREADTHRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNU4</accession>
    <name>D6SNU4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1778"/>
    <dbReference type="EnsemblBacteria" id="EFI34420">
        <property type="protein sequence ID" value="EFI34420"/>
        <property type="gene ID" value="Dthio_PD1778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7602" checksum="EB4ED6FEAB2EC4DB" modified="2010-08-10" version="1">MLAERGEYGSEKVAIEIETLRILEGHLAPRALGLVIEWASQHRDELIQNWELARNNQAPRKIEPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNV6</accession>
    <name>D6SNV6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Malate synthase G</fullName>
            <ecNumber evidence="10 12">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glcB</name>
        <name evidence="13" type="ORF">Dthio_PD1791</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 12">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10 12">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the malate synthase family. GlcB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="10 12"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869754.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1791"/>
    <dbReference type="EnsemblBacteria" id="EFI34432">
        <property type="protein sequence ID" value="EFI34432"/>
        <property type="gene ID" value="Dthio_PD1791"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="322024at2"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00641">
        <property type="entry name" value="Malate_synth_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006253">
        <property type="entry name" value="Malate_synthG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42739">
        <property type="entry name" value="PTHR42739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01345">
        <property type="entry name" value="malate_syn_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 12" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0558">Oxidation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="10">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyoxylate binding" evidence="10">
        <location>
            <begin position="459"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 11">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine sulfenic acid (-SOH)" evidence="10">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601465-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI34432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="727" mass="80861" checksum="0CB4176C85AE8690" modified="2010-08-10" version="1">MEYVRWAGLQVAEPLAELVENVITPGTGISSLQFWKALQEIVQDLGPRNQALLDRRRELQDSIDQWHLQRRDLEHPGQEYKKFLYDIGYLLPEGEDFTISTTGVDPEIASIAGPQLVVPVNNARYAVNACNARWGSLYDALYGTDVIPDMQGAQRGQGYNPVRGEMVVKSAAGFLDRAAPLEEGSYSQAVGFELQDSPRGKALMVRQQDNSTSGLANAEQFAGYAGEDRLESILLKNNGLHIEILIDPDDPVGGRHPAGVKDVVLESAVTTILDCEDSVAAVDPEDKTLVYSNLLGLFKGELETAFYKNDQLIKREMHPDRSYVSPDGQSFCLPGRSLMLVRTVGHLMTTDAVLDGQGGEIFEGILDTMITALAGMHDLQGQGRFGNSRSGSLYIVKPKMHGPEEVQFTCELFARVEDALGLPRNTLKVGVMDEERRTTLNLKECIRVARERIIFINTGFLDRTGDEIHTSMEAGAMVRKGDMKKEPWMLAYEDWNVDTGLACGFRGRAQIGKGMWPKPAEMREMVMDKLSHPMAGANCAWVPSPTAATLHATHYHQVNVDARQAELEGQRRAKLDDLLNVPVIKDKMPSSEEIRQELETNAQSILGYVVRWVEQGIGCSTVPDISDTGLMEDRATLRISSQHMANWLHHGLCTREEVLEVLRKMATVVDRQNAHDLMYRPMSRDFDSSPAFQAACDLVFEGRSQPSGYTEPILHSKRREAKSRFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNZ2</accession>
    <name>D6SNZ2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF364 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869790.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1827"/>
    <dbReference type="EnsemblBacteria" id="EFI34468">
        <property type="protein sequence ID" value="EFI34468"/>
        <property type="gene ID" value="Dthio_PD1827"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1905652at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007161">
        <property type="entry name" value="DUF364"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04016">
        <property type="entry name" value="DUF364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF364" evidence="1">
        <location>
            <begin position="104"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="26838" checksum="A436DDA90B9D4E30" modified="2010-08-10" version="1">MQITQQQIISEIVHEARTRPDSAVRELVQGQLLVGVQAEQGAGICSRVPLDDVPLDSGHEPGQNQSLHQLLPGLQNQDTVQASFALASANCILNSRRGEIQAKAQELILELGQGKNVAVIGHFPFVSKIKNAFKNFWVLEKRPRDFDLPSTEMPRILPRAQLVAITATTLLNGSLAGILNLCDTGSIRVLMGPSTPMACCLGRMGIDYLAGSRVLDSRQVFTGIKNGLCFRSLSGVENFIQPTGRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNZ7</accession>
    <name>D6SNZ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869795.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1832"/>
    <dbReference type="EnsemblBacteria" id="EFI34473">
        <property type="protein sequence ID" value="EFI34473"/>
        <property type="gene ID" value="Dthio_PD1832"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="280" mass="31645" checksum="0015BEB2589F1540" modified="2010-08-10" version="1">MLVSVIIPTYNRAGYIGSAVRSVLTQSFRDLELIVVDDGSTDATREILSGFDDKRLKAVYQENSGVAAARNLGLDLAGGRYVAFLDSDDFWLERKLEMQLAFMHKSGFCISQTQEAWIRKGKRVNPGHRHQKFAGWIFARSLKMCLVSPSCVLMHSDLVRQGFLFNESLPACEDYDLWLRISLSYPVGLLSRVLTVKQGGRGDQLSRSIIGLDLWRIQALLDILNGERLQPEKKALVLQALLEKSRVYIAGCQKRGRLEEAARIKQKLDSCLNQVNLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP08</accession>
    <name>D6SP08_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869806.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1843"/>
    <dbReference type="EnsemblBacteria" id="EFI34484">
        <property type="protein sequence ID" value="EFI34484"/>
        <property type="gene ID" value="Dthio_PD1843"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="5">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="160" mass="16699" checksum="05E48D0877B261C0" modified="2010-08-10" version="1">MQILVLYYSKSGNTRKLAEAVARGVDSVEGAQAIIKSTSEVTKDNFLNCSGVIAGSPVYFGVMAADLKRVIDEFISLRKKMEGKVGAAFATSGDPTGGKETTMFSIIQALMIYGMVIVGDPMSATGHYGTACVGEPDEKAGENGAKLGARVAEIALKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP23</accession>
    <name>D6SP23_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD1858</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1858"/>
    <dbReference type="EnsemblBacteria" id="EFI34499">
        <property type="protein sequence ID" value="EFI34499"/>
        <property type="gene ID" value="Dthio_PD1858"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="423"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="689"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="842"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="12">
        <location>
            <begin position="1058"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="998"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="998"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="891"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI34499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1154" mass="127335" checksum="505782852C60D1E6" modified="2010-08-10" version="1">MMTQSERHPPAFEPGSSPARPLSRGPRANGRFVTLILAVVWLLVLGGSLAWNWRHVGVSLTDLAETEAHSAFMKDVTYRLWASMHGGVYVPPTEATPPNPYLSHLPHRDVVTADGRELTLVNPAYMTRQVHELGRQEYGLVGHITSLQPLRPANAADPWETEALQTFLDGADRAVTVEQMDGQPVFRLMRPLVALPSCLTCHSEQGYQEGDPMGGISVSVPLRPYLDAAGQQRLFLLVAHGLIGGLGLSGLVWAGRSLRRSGAELLRSETRFKTMFHDSPVAIYINDAQSGTILDANQAACNLCEYASLEELQTGNIWLDPQYSFAEAQEWIRKAVEQGPQVFEWHMRSRSGRSFWVQIHLRCIEVNAAPCVLATAIDITERRQAEEKLHETARQMERKTVELDAALTRADAASKAKSEFLANMSHEIRTPMNGVIGMTGLLLETDLNETQRRYAETVRSSGQALLALLNDILDFSKIESGKLELEALNFDLRDTLDNFASMMAFKAEEKGLEFICSADPDVPDNLIGDPGRIRQILTNLVGNAVKFTERGEVVVRVSIQESGVRRQETGDKSQETGDKSQETGDKSQESEEFCMLRFSVRDTGIGIPEDKIGLLFQSFSQVDASVTRKFGGTGLGLAISRQLAELMGGEVGVESIEGQGTTFWFTVPLSLAETCDQIPSMSADLRGLRALVVDDNATNREILLTRFLDWGLRPDEAKDGPTALGRLYTALAEDDPYHLAIIDMQMPGMDGEFLGRTIRADQKLQDVRLVMMSSAGMQGDARRMKDIWFAAFLAKPLRHDELFDCLSLVMAGDEPQDLVTRHSAREEKSRSGKIDFSDRKARILLAEDNITNQQVALAMLKNFGLSADAVANGLEAIKALKTVPYDLVLMDVQMLEMDGLAATRRIRAAEIRGRELEVRDQRLKSESQNSSIPESLNPLIPQSLNSRIPEFRIPIIALTAHAMQGYREQCLEAGMDDYLTKPLEPVQLAEMLDKWLGKEEAESRDHSHGDEPGSAGWPEGKAGEEAGGNTGEERAAAQGGGDLPVYDREKLLEQMSGDQEFIQVIVQMFVEQNTERLEVLLRAIIDGDLAAVRDHAHAIKGSALSVSANALAEMASRLEVAGRDEDLAACTSLGPRVEWEFQRLLSELGVMKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPJ4</accession>
    <name>D6SPJ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869990.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2042"/>
    <dbReference type="EnsemblBacteria" id="EFI34670">
        <property type="protein sequence ID" value="EFI34670"/>
        <property type="gene ID" value="Dthio_PD2042"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="133139at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="874" mass="102086" checksum="CDA3711236EE0631" modified="2010-08-10" version="1">MKFKYLTAILLFLVQLCLMHGLAGAMEYYWGSHPDHERIVFEFQEEMPDYSAFRSARERIDVVLPEDIRQHIRIPEEVDFSAADLIQNVQFLDHRIQIYTGSAEFGFISFTIPEENKIVLDIFEDRLGDKWEAPVEFPELADEARRQPEEPEEPPAPEEDALDDPGLEPEPGHRMRQQVQRVGPEEAGLVLHEADADRVEAPQETEELFDPPEVPDREPDDPGVTPAELQEEPPPAEMDRYEEMIAAGQMAMSGAEYAIAADIFEELKNDPQLPEEHTEEVLYSYAQANFQEHSHDIPGNFQDVLRPFERAVSANPGSDRLPEALLNMGYIHLQVGNEPEARGYFDLLRDRFPEHEAVPATHYYMGEHYKDRERYEEAADEFEEVVQEYPQDDLVKPAAVALTRVLNELNLDEQAGDMLEYIDNRWPRYHLDDPDFLVLAGNILYRNEDYQDAREKFMHYINLLPDGDQVDVSMARVGDILYQQGHEDSAREMYEQTARQYSDDEGGLIAQMRLADRFGDETIRPRLLYERISEEFPDSPLAPVALLRLADWNLDNGLYDEAMDNVEDFYDRYSHREMWPRALQTGVDAFESLVAENFPDQEYDDIIDAWERHDYLNENKDMLDREALLALASAYWDMENMQESLRLAEPFLDMDKIDEHNIAALSLMLTIALDTRDWERILDLADQVEGWDLPENKELQLKYATALAKQNQGLEDEARPLWRELAVETDLPDRQRAFALFFMAEHSIQREEYENAYVFAQESLALFRDQDDPDVSRIRSNLEFLMDATAYTGRHREALGWALEFEDYIEEDDPDWPAYRYRLANLYRLNGEHQRWERILQELAEDYPQDLHGRMAELDLNAQRLDREVDRFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPR3</accession>
    <name>D6SPR3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid stability-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870057.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2112"/>
    <dbReference type="EnsemblBacteria" id="EFI34739">
        <property type="protein sequence ID" value="EFI34739"/>
        <property type="gene ID" value="Dthio_PD2112"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="8813" checksum="550EFF9AD1514F0E" modified="2010-08-10" version="1">MFLLDANVVSELRKIRRGKADPGVMPWAEGAVSSAFYLCVITAQELEIRILLADIRDPEKGKILRFWLKGRTLKALDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPV5</accession>
    <name>D6SPV5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870097.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2157"/>
    <dbReference type="EnsemblBacteria" id="EFI34781">
        <property type="protein sequence ID" value="EFI34781"/>
        <property type="gene ID" value="Dthio_PD2157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7359" checksum="5D03726078D7A8B4" modified="2010-08-10" version="1">MNRRSVLDASFDRSRGGNIHAEGDAADIIGYAVAATIVFTGTAWAYVLTRKKNDNHGKPARKKRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPV9</accession>
    <name>D6SPV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870101.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34785">
        <property type="protein sequence ID" value="EFI34785"/>
        <property type="gene ID" value="Dthio_PD2162"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2165417at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="194" mass="21606" checksum="527955F7842EAE75" modified="2010-08-10" version="1">MNKGFSSLRDKVTSAVDKAGEFISKERSIQLSQKVINQALQAEEETVKGLRQKGLSRVQVDIEKDRIDATGLIQDKNMQFEIGLVPKEVSWNRQEQLMHFQVDGLKIKSTVQGVFPAIKTAFIHMVLTVIGAHRALKLTGLDIQEGSIRLDVRDLLKSAAGIAGLVQIKSIHAEPATLRIVYKPDIENVFNPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPZ5</accession>
    <name>D6SPZ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PglZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870135.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2209"/>
    <dbReference type="EnsemblBacteria" id="EFI34821">
        <property type="protein sequence ID" value="EFI34821"/>
        <property type="gene ID" value="Dthio_PD2209"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="467452at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PglZ" evidence="1">
        <location>
            <begin position="405"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="667" mass="75592" checksum="2112A7B626F38C17" modified="2010-08-10" version="1">MTGWREHILADFSPGTVGLTLVADPDGLLLEAGMLERIQERGFALIPFESHVEFRFAFESSFRSKWDENLEKEQAVVVHVTQDDLQTLPYDLLQAGRRLHFSLAGIFPNFSYPVLAALDKSDLDALYLAQKDLASERLGDRSSKDFILRHVYSIAPELLKHTADLLRMLLRMHYRQIHLPSLFQEHLIQEIEKNGRFSDWPLGTIVPDREAFLAFLQERWEYFIQQKSSQQIASLQENRGVFNPVYPGPVDLPFEHHDVRVYLDTLFLDGLLEPVDHPQSQALSETWVSLGVRIDPEADRIKRLEKLYSSLRDDLPGQQARHGKWLTFARSWAELLALWLQTDKEPVPGIEDKIRAVQLELDNTLAVWAENKLGGLINLPPVPPVMLHHIPRFLARSLEQTQGGKVALVVLDGLSFDQWVTMRKVLALNTDFLFRENAVFAWLPTTTSISRQALFAGRPPVFFPDSIHTTGKEAYLWRQFWADHGIKEQETVYARGLGDDITDELHHQLVSPQTRVAGLVVDKVDRIMHGMELGLSGMHNQIRQWAGQPFLGYLLDVLLQAGYQVFLTSDHGNIQAAGCGRPAEGALAASRGERVRIFRDPALRERVASSFPEAIAWSGSGLPEDVFPLIAPHRQAFVSNTRQLVCHGGISLEELVVPLVQIERKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ06</accession>
    <name>D6SQ06_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870146.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2222"/>
    <dbReference type="EnsemblBacteria" id="EFI34832">
        <property type="protein sequence ID" value="EFI34832"/>
        <property type="gene ID" value="Dthio_PD2222"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10194" checksum="E0B47B5AD3DF9A64" modified="2010-08-10" version="1">MAIQTTYTHARAKLSSLLDAVTQDREVVIIQRRGQEDVALISADELAGIFETAHLLRSPKNAERLYAALDRVKKPSGSPQTIEELQSEVGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ50</accession>
    <name>D6SQ50_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870190.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2267"/>
    <dbReference type="EnsemblBacteria" id="EFI34876">
        <property type="protein sequence ID" value="EFI34876"/>
        <property type="gene ID" value="Dthio_PD2267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="PTHR43306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01100">
        <property type="entry name" value="methyltransferase_(Class_D)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="103"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="534" mass="60805" checksum="C4B155500158AAE8" modified="2010-08-10" version="1">MFLDKIWGKKTEQTVENLPLSTRSLCPECRETIEAQLVEENGQVLMYKTCPEHGEFREIISADRDFFMKMRRTHYERPAGLDRPQTKVEQGCPHDCGICPSHRSFPSMVNIDLTNRCNLNCPICFANSNAMGRVYELDWEQINHVIDSVAALGPHPVICVQFAGGEPTIHPHFLDAVRLAKSREFAQVQAASNGVLFAGNYGFAEKAAEAGLDVVYLQFDGMSDDIYRDTRGRPMFETKMQAIDNLGRAGIRVALVPTIVKGFNDHQVGDILRFAVRNPEVVTAISWQPVSFTGRIDESRRQEMRFTTADLARELQEQTGLLDMHRDWYPFSIVSPLSRFLEAVTGEKKAHTNCHPHCGCVTYLVVDKQTGQAVPFPAFLDVEALAASLNKKAGRLEHYPWLKNALSLQFKGELKKHFRRENAPEGWDHETLMQFVDSLIHLGEGHKVDKKVQKEAIQGRRFEIIMSAAMHFQDLYNYELDRVQYCAVHYADPEGRLYPFCTWNSGPCHRYRVEEMYARALNKNRQAETETAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ51</accession>
    <name>D6SQ51_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870191.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2268"/>
    <dbReference type="EnsemblBacteria" id="EFI34877">
        <property type="protein sequence ID" value="EFI34877"/>
        <property type="gene ID" value="Dthio_PD2268"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="179"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="447" mass="50831" checksum="F580A26ADD9C3AA3" modified="2010-08-10" version="1">MRILLINTPFHSAYKKFTQEFPPLGIAYIAGMLRKSGHDVHLLDLNASDTGEYPGFRRFDLIGISADTPRHDKALALAAQAREHQVPVALGGPHVSFLPEESLKSGYVDYVVRGEGEYPMLYLAEFLAGERSLEDVPAVSYLLEGEAVHNPDQCIAKDIDSLPFPARDLLPMDKYRTHLNKKRATSMISSRGCPFNCSFCASSQLFGARWRAREPEAIFDEIEHVQQRYQVSNILFVDDNFTLDPQRTVRISELICKKDLNIQWLCFSRVNTIVENEDMVQGMAESGVRMMFLGVESPDPRVLESYNKKITAETSFRALEILKKYSIDALASFIIGNLNEDSRMIKNTIRFANKLNPKTAQFSILTPYPGTRLYNEVKDRILTFDWSRYDGMHATIKPDRVRAEELERLIKKAYVSFYLHPGKILAHPVAGMRNLFMVPRLLKAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQC3</accession>
    <name>D6SQC3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870263.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2341"/>
    <dbReference type="EnsemblBacteria" id="EFI34949">
        <property type="protein sequence ID" value="EFI34949"/>
        <property type="gene ID" value="Dthio_PD2341"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZGVQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1921194at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="115" mass="13253" checksum="3541D986885C5716" modified="2010-08-10" version="1">MGEIIQIRVMAQTFDPEEAKKRWSDLAEAAFDMDSLQIKAEKDFHIKLVDALVDRNKLGQLSPNLKEAIQKDLQTAGQLRDKLQRSLSDWDPRAADRAAYELEDVLDRMQQNVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQI8</accession>
    <name>D6SQI8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH/Ubiquinone/plastoquinone (Complex I)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870328.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2407"/>
    <dbReference type="EnsemblBacteria" id="EFI35014">
        <property type="protein sequence ID" value="EFI35014"/>
        <property type="gene ID" value="Dthio_PD2407"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="112"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="620" mass="68668" checksum="E12CD9AA849B90CC" modified="2010-08-10" version="1">MMTFNIPPFLILLLGGLLLPLLPGRIRTWFFLVPPLLALWTIFNLEVGTKVAIDFLQFELIFLEVTQLNWIFGIIFSLISIIAGVYALHMDDLRQQAAAAFYATGALCVTFAGDFLTLYLGWELMAVASTFLIWARGTPESIATGIRYFLFHILGGVVLLGGILLHVADTGSLELTSFADGQSLAAWLILIGVAVNVAIPPLHAWLSESYPMATVTGAIFMSALTTKSAVYVLASLFAGWQILIFMGVLMALYGVVYAVLANDIRGILAYHIISQVGYMVAGVGIGTEMAINGTTAHAFSHILYKALLFMGAGVVLYTTGKSKLTELGGLYNKQKLVFWLYMIGAFSISGFPLFNGFISKSIIVASAGYESMDVAALLLILASIGTFLHTGLKLPYWTWFGQDSGLTPSRTPRNMIWAMGITAFLCTFFGIYPWLLYANLPFPEVVYNPFQVYHFIEMTQLLIFTYIAFWVFRKKLAGEPYVAVDFEYFYRLAGKACLKIAYVPVATVDNWLSELYARTSRRMVRFSRAIIAPGEDKYDIAINRKIPDGIKHFSFIVVADRMERGADSACHSIMPRFIVRTGNSLLNLIRADSKDLSSNLVYIIALTIILISLALIRMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQJ6</accession>
    <name>D6SQJ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870336.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2416"/>
    <dbReference type="EnsemblBacteria" id="EFI35022">
        <property type="protein sequence ID" value="EFI35022"/>
        <property type="gene ID" value="Dthio_PD2416"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1987527at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="211" mass="23911" checksum="317EF1F5B6D6C266" modified="2010-08-10" version="1">MAQISSGDRSHPGFLVQHRGIIIQAVLLMALWLVLSGRFYPEPIFYGIISVAFVVWLNMGVRHIPLSSGEYLSGHQIYFSRLLLYIPWLLWQIAKSAAFVAYLTLHPRMPINPMVVTFESRLPNPIAKVILGNSISLTPGTLTLDIYENQFTVHAIVDEVEEDLVSGDMESRVGRLYLRRCTPEEMCNGVCILKRGKEIKKAMEHQEEDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQX2</accession>
    <name>D6SQX2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_37 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870462.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2543"/>
    <dbReference type="EnsemblBacteria" id="EFI35148">
        <property type="protein sequence ID" value="EFI35148"/>
        <property type="gene ID" value="Dthio_PD2543"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1946648at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_37" evidence="1">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="109" mass="12458" checksum="BCC98F1EEDDF8873" modified="2010-08-10" version="1">MNEDIEVVRGSGNVFRDFGYQGSDVEQTKSILAARIIGVLNDMELSTRKAETLTGINHSEFARIRRVKLDRFTIDRLITILNRLNQRVEFDIKLFPRENANSGFSLVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR25</accession>
    <name>D6SR25_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0461"/>
    <dbReference type="EnsemblBacteria" id="EFI33141">
        <property type="protein sequence ID" value="EFI33141"/>
        <property type="gene ID" value="Dthio_PD0461"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YHH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2039087at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9942" checksum="89647B13E25BDFE3" modified="2010-08-10" version="1">MPTYLYTKYFEEQVLKKRPYLKKEWCVEVVENPIKSEPQEHNRYRFWGRIPELDNRILRVVTLDDKVTIHNAFLDRRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRA5</accession>
    <name>D6SRA5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870579.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0547"/>
    <dbReference type="EnsemblBacteria" id="EFI33221">
        <property type="protein sequence ID" value="EFI33221"/>
        <property type="gene ID" value="Dthio_PD0547"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2035652at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009577">
        <property type="entry name" value="Sm_multidrug_ex"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06695">
        <property type="entry name" value="Sm_multidrug_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17168" checksum="9D1C3A6652C4EC7F" modified="2010-08-10" version="1">MEALWQYFLVFILSATPWIEILLVIPAALAMSLDPWLVGILAFAGNTAPIFIMVYGYELWRKWRAGKAKGYARPASRRRRRALRIWNRYGLPGLSLLAPALTGVHLAVLIALTFRTSKKDLLVWMNISLVVWTTGLTLGVYYGIEGLRFLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRB4</accession>
    <name>D6SRB4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870588.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0556"/>
    <dbReference type="EnsemblBacteria" id="EFI33230">
        <property type="protein sequence ID" value="EFI33230"/>
        <property type="gene ID" value="Dthio_PD0556"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="154"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="311" mass="34702" checksum="F115765DD982BD03" modified="2010-08-10" version="1">MPKTESHIFLISSDAELYTTLKSICSHAQWTVFERGRGAIELLFNSPPDLLIVDNKMPDLQGTELIRIFKSENVYRQVPVVLCLDREEVDAGPDLAALEVDDFLVKPLDPGESRLRLELIMARASWELDANPLTKLPGNTSIIQKIQDMLDRQQEFALAYADLDNFKSFNDKYGFSRGDEVLMMTARVIVNTIRAFAGMESFVGHVGGDDFVFIVPPDKAESVCSMLVQNFDGIVPNFYDPEDLKQGGIHSTTRDGKASFFPLMAVSIAVVFNKKGELTHYGEASEKAMNLKSIAKKEPGSSYVLDRRQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRF5</accession>
    <name>D6SRF5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ORF">Dthio_PD0597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870629.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0597"/>
    <dbReference type="EnsemblBacteria" id="EFI33271">
        <property type="protein sequence ID" value="EFI33271"/>
        <property type="gene ID" value="Dthio_PD0597"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI33271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="170" mass="17906" checksum="0851AD6F4A591262" modified="2010-08-10" version="1">MTSSSSGLVILGIDPGSRCTGYGVVRETSGCLELLGTGTIRTNGQDDLSTRLDTIFTRICSLIHEFSPDQAAVEEVFTSKNASSALKLGQARGAVIVACSHQKVPVYSYEPTLVKKSLVGGGRAGKEQVAFMVAQMLGCKPRWAQDASDALAVAIAHLNQRRAAGFGGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRJ4</accession>
    <name>D6SRJ4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2179 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870668.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0637"/>
    <dbReference type="EnsemblBacteria" id="EFI33310">
        <property type="protein sequence ID" value="EFI33310"/>
        <property type="gene ID" value="Dthio_PD0637"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747063at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="225"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="287" mass="32024" checksum="FC62F980EA6E0972" modified="2010-08-10" version="1">MSSYLLRFTYTIWWNLLLIALGSVIFAIALKGIMVHHKFIPGGAFGVSLLTYYSTPVISAGVLYFLINIPLFVLGWLYVSRRFFGYSLFAMVVATLAYEGISIDLGIQDQLYAAIAAGAMGGFGCGIVLRSLGSNGGLDVIAIMLNQKFNFGIGKFYFVFNFFLFSISLLILDIDLVIASLILVFIMSYIVEYTLSMFNNRKLVLVISDKNEEIAEDLMHRLKIGTTFLRGRGGYTGQDKNIIMAITNNIMLKRLEQAVFSVDPQAIFIVENTFSVLGTSFSQRKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRK6</accession>
    <name>D6SRK6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870680.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0649"/>
    <dbReference type="EnsemblBacteria" id="EFI33322">
        <property type="protein sequence ID" value="EFI33322"/>
        <property type="gene ID" value="Dthio_PD0649"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711992at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="274" mass="31251" checksum="81D5250FE77FF3DB" modified="2010-08-10" version="1">MSKAEIKNIYPEELAEFSARHKESEYVLVDVRQPQEYTQEHIPGARLIPLHELEGRLGELDPGRQAVFYCRSGKRSMTAAVLARDSGVFDTDILNLEGGITAYQNRVLPDYPRVDIFSGSSDLKTVLSRAVSLEKGAEKFYTGFLESIRDESLKDQLQKLAGLERAHARVIFAQGKHLFDEDFDSFFSKAEDSIVEGGLNVSGWAQKFKHLNQSELCLYFLEVALEIETMAYDMYRNLAENKDYPREAAECFFRLSEQEKGHMRLVARLFKDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRL4</accession>
    <name>D6SRL4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870688.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0658"/>
    <dbReference type="EnsemblBacteria" id="EFI33330">
        <property type="protein sequence ID" value="EFI33330"/>
        <property type="gene ID" value="Dthio_PD0658"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10019" checksum="A1B29FDB021C2DFC" modified="2010-08-10" version="1">MWRVVFAKQAQRDAKKLSAAKLQSNAQILLEILRKNPYQSPPPCEKLAGDLTGACSRRINIQHRLVYQILDDEKVVKIIRMWSHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRP1</accession>
    <name>D6SRP1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly PilZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33357">
        <property type="protein sequence ID" value="EFI33357"/>
        <property type="gene ID" value="Dthio_PD0685"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DMC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="53"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="173" mass="19748" checksum="1A5C1BFAB6E4EFA8" modified="2010-08-10" version="1">MTRYLEKTVYIKENILDKLEMLAKKNSLSLSTLLNHIFTKYLESRNGYDQLEEKRKSARKKVVIPALVYEKTQNGGNGEDFDMGRYISTTIFDISRGGLRLVVPAGKNGGMQFAKPQSEFEVISYLSGNSTLFRLKCRAEHIEQNENGVKVGSSFVEEANFQMDKLEVYCLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRQ2</accession>
    <name>D6SRQ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870726.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0696"/>
    <dbReference type="EnsemblBacteria" id="EFI33368">
        <property type="protein sequence ID" value="EFI33368"/>
        <property type="gene ID" value="Dthio_PD0696"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="567" mass="62671" checksum="A18D1E4B0B960E29" modified="2010-08-10" version="1">MRTKMRLGEMLIQEGLLTQQQLEKSLSANRGTGLKLGQFLVRNNICREDNIVDMLSRQLRIDRYDPSRYPVDSSLADLITSDQAREYNTVPLARSGKLLRVATPDPLDLESLDALEVVTGLEIEPVVCTESDFEQVYGSLYGMYWNIDDVLEDVEQEELSVEDQQGGGGETQDIHTLEEEADQGPVIKLVNSILAQAVKQGASDVHLSPEKNRVQARFRVDGKLREVPSPPLNMMPSIVSRIKVLAGMDISVSRMPQDGRFTVGMKGREIHVRASCIPTIHGENVVLRLLDLSARTFELEELGMNSDDYQKMSEAIDTPYGMILASGPTGSGKSTSLYAILRRINQPDINIITLEDPVEYRVQGVRQVQLNTRSGMTFASGLRSILRQDPDVIMVGEMRDAETARIGVQAAMTGHRVLSTLHTNDAAGAVARFIDMGIEHYLVSSVLVVSFAQRLMRKNCSKCAKPYTPSDRALKAMGLENSTDCTFMQGQGCYSCMNTGFSGRTAAFEVLRVDDEVREMIQTGTTGTQMGRSLSRSGKLHDLRSDAARKVCQGMTTVEEAMTVVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRT9</accession>
    <name>D6SRT9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0737"/>
    <dbReference type="EnsemblBacteria" id="EFI33405">
        <property type="protein sequence ID" value="EFI33405"/>
        <property type="gene ID" value="Dthio_PD0737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="6967" checksum="9F34588E8EDD04DE" modified="2010-08-10" version="1">MNRNNIFNTIKKYREKSGDEFGILRIGVFGSLAKGQENSASDVDVVVDFEASKYLILLKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRW2</accession>
    <name>D6SRW2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0762"/>
    <dbReference type="EnsemblBacteria" id="EFI33428">
        <property type="protein sequence ID" value="EFI33428"/>
        <property type="gene ID" value="Dthio_PD0762"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="185" mass="21382" checksum="F9D21D7231608936" modified="2010-08-10" version="1">MKSFKWNTEKNQLLAKERGITFEEIVQGIEAGNKVVEVDHPDQKRYPGQKIMIVDMQGYAYLVPFVFDGQGDIFLKQLSRAERRPKNIWEGWMSEDNKKMNLDGYESEILEAYEQGRLSPSYSQTDFQAVARNTMKKTRKINIRISENDLNALQRKAAREGIPYQTLIGSVLHKYASGFLKESPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRY5</accession>
    <name>D6SRY5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">F-type ATPase subunit c</fullName>
            <shortName evidence="12">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">atpE</name>
        <name evidence="15" type="ORF">Dthio_PD0785</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870803.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0785"/>
    <dbReference type="EnsemblBacteria" id="EFI33451">
        <property type="protein sequence ID" value="EFI33451"/>
        <property type="gene ID" value="Dthio_PD0785"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2078221at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088171" description="ATP synthase subunit c" evidence="13">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="12">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI33451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="10739" checksum="1AB85D9995ECB7B2" modified="2010-08-10" version="1">MRKSLLIIFHTVFFVGLASVAFAGEVAPEVIGNIALATGLGMGIAAIGTGIGQGIGLKGACEGTARNPEAGGKITVTLLIGLAMIESLAIYALVINLILLFANPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS97</accession>
    <name>D6SS97_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870913.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0897"/>
    <dbReference type="EnsemblBacteria" id="EFI33563">
        <property type="protein sequence ID" value="EFI33563"/>
        <property type="gene ID" value="Dthio_PD0897"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15368" checksum="713B8D3F9773A72A" modified="2010-08-10" version="1">MKGLLVDSNIILDVFLDDPVWAEWSEAALSEYAHHAPLYINQIIYSEISIGFNKIEELEAAVSKSGFQMLEIPRESLFLAGKAFFKYRKHKGAKKSPLPDFFIGAQAAVLDLELITRDKNRYQTYFPTVKIISPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSA8</accession>
    <name>D6SSA8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase, subunit ChlI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870924.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0909"/>
    <dbReference type="EnsemblBacteria" id="EFI33574">
        <property type="protein sequence ID" value="EFI33574"/>
        <property type="gene ID" value="Dthio_PD0909"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="581802at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="214"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="510" mass="55910" checksum="A257992F89ED11C0" modified="2010-08-10" version="1">MFAKITTAALLGIDAIRIELEVDYSRAGMPAFTLVGLAEGAVKESKERVFSALKNSGYKLPPARITINLAPADVRKEGSSYDLPLALGLLAASGIVPAENIQNIFMSGELSLTGELKAINGSLPLALKARNDKARAVMVPAVNAQEAAVVQGIPVYGMDSLGQAVRFLSGEIDQEPVHFDIDTLWQRGADFLVDFSEVKGQDNAKRAIEIAAAGAHNLLFIGPPGSGKTMLAQRIPTVLPGLSFEEALEVTKIYSVSGQLDPQQAMIVQRAFRSPHHTISDAGLIGGGHYPRPGEVSLAHRGVLFLDELPEFKKHVLEVLRQPLEDGEVTISRAAMSLRYPADFMLVAAMNPCPCGYLTHDQHPCTCTPTQIQRYRYRISGPLLDRIDLHIEVPSVPYEELKKARSSMDSGEMKASINRARQIQEKRYQDLPFLTNSQLSGKWLSEFCSLGQEEHAFLEVAVQRLALSARAHTRILRLARTVADLEGQEHISTAHLSEAINYRSLDRQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSE4</accession>
    <name>D6SSE4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="4">2.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L/F-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Leucyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phenyalanyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aat</name>
        <name evidence="5" type="ORF">Dthio_PD0945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:50416"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64719"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133044"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:12340"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12670"/>
            <dbReference type="Rhea" id="RHEA-COMP:12671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65249"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133043"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:43632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10637"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83561"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the L/F-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870960.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0945"/>
    <dbReference type="EnsemblBacteria" id="EFI33610">
        <property type="protein sequence ID" value="EFI33610"/>
        <property type="gene ID" value="Dthio_PD0945"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1670846at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042221">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="244" mass="27249" checksum="9F5E9BBADAFCB105" modified="2010-08-10" version="1">MTITFLSRNLEFPHPGQAGPDGLLAVGGDLTPERLIAAYSRGIFPWYGPGSPILWWSPDPRLVLFPGSLHIPRSLRRVLNSGKFTITADQAFEKVIEYCAGIKRAGGHGTWLVPEMISAYIRLHHMGIAHSVEAWHRGQLAGGIYGLALGSIFFGESMFYRVPDASKTALVYLCRIMQNKGYLLMDCQQTTRHMLRFGAQEVSRAFFLEELGKGKNQTRDRTEKWDFSCNPSGFFIPENGRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSG6</accession>
    <name>D6SSG6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0967"/>
    <dbReference type="EnsemblBacteria" id="EFI33632">
        <property type="protein sequence ID" value="EFI33632"/>
        <property type="gene ID" value="Dthio_PD0967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="39" mass="4568" checksum="A12F3680AABE6AEF" modified="2010-08-10" version="1">MYISPKVHDAADFSQVPHLPLFLWKMPVNRRLSPFTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSQ1</accession>
    <name>D6SSQ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871066.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1056"/>
    <dbReference type="EnsemblBacteria" id="EFI33717">
        <property type="protein sequence ID" value="EFI33717"/>
        <property type="gene ID" value="Dthio_PD1056"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="185" mass="20802" checksum="AC0C2740129D4CCD" modified="2010-08-10" version="1">MISNMKFITVFFVAMVAFLFLPPGSKASVQEGDSLEGVTFPAPATQEAAEQLGLEKMEPFSLDNLDREYVLFKVVDVYCPVCHEQAPEFNRLFNRIQDNTSLAESMYIFTLAPEASPGEVEHLYQAWETPYPILGDHEYILPGKIGSLDTPYTIMVNREGKVVYAHGGVMPDTREMMGKLRELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSS4</accession>
    <name>D6SSS4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CheW protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871089.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1079"/>
    <dbReference type="EnsemblBacteria" id="EFI33740">
        <property type="protein sequence ID" value="EFI33740"/>
        <property type="gene ID" value="Dthio_PD1079"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="173" mass="18919" checksum="2029AF904DC7DD07" modified="2010-08-10" version="1">MDNAKAGLSNTYLTFYLDQDLFGLNIDSVREVLEYTSITKVPRTEDYMLGVINVRGHAVPVVDLRVKFGLGQGEKTVDTCIIIVELSIHEESSIMGALVDGVQEVLDIPPEQIEKAPRLGSKIDTQFIRGIGKLEDKFVIILDIQSVFSVEELSSITEKSDQVSAESVASGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SST2</accession>
    <name>D6SST2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxylyase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1087"/>
    <dbReference type="EnsemblBacteria" id="EFI33748">
        <property type="protein sequence ID" value="EFI33748"/>
        <property type="gene ID" value="Dthio_PD1087"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="612" mass="68527" checksum="96D597522852473C" modified="2010-08-10" version="1">MGYTNMRHCLEDLEARGDLVRISTEVDPYLEAGAIQRRVFQNKGPALLFTNVKNTTFPMAGNVFGTMQRARYIFRDTLDTLDRLFKLKIDPLLFFKAPWKYLDVLPMLARTMPKRVSQGPISRGETTIERLPQLVSWPMDGGAYVTLPQVYSENPARPGIMQSNLGMYRVQLTGNDFRTNREVGLHYQIHRGIGYHHKLALEAGEPLRVNVFVGGPPAMTLAAVMPLPENVPEVVFAGSLGGHRIKMVQAANGLPMPAEADFCISGRIVPGRELPEGPFGDHLGYYSLRHDFPVLRVEKVHHRVDAVWPFTTVGRPPQEDTVFGDLIHELTAQLIPTVFSGVREVHAVDAAGVHPLLLAVGRESYVPFARQRQPQELLTNAMNLLGQSQTSLAKYLVIAALEDDPGLSARHIPRFLQHVLQRMDFARDLHFITRTTMDTLDYSGISLNQGSKLIMAAAGEVKRRLGMKLPRDLPLGEFSRPRFMAPGIMAVQGPRSTQERDTHDPEVEKLGERLNNAPGMQEFPLVVVVDDSDFVTRCWDNFLWAVFTRSDPATDTYGMGAFVHCKHWGAEKGIVIDARLKTYHPPVLEPDPQVEKRVDELGARGGPLYRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSU9</accession>
    <name>D6SSU9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1104"/>
    <dbReference type="EnsemblBacteria" id="EFI33765">
        <property type="protein sequence ID" value="EFI33765"/>
        <property type="gene ID" value="Dthio_PD1104"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="6">
        <location>
            <begin position="4"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="382" mass="41741" checksum="31853270C95DFE64" modified="2010-08-10" version="1">MRKTAYFIEGDGIGPEVWQATRPVLDKALDKAYSGQHSLEWVELLAGEKAYKETGEYLPARTLDTLREAELAIKGPLATPVGGGFRSLNVTLRQVLDLYACIRPVRYFQGIMSPLKRPELVDMVVFRENTEDVYAGIEWAAGSPEAEKVASFLRDEMKADIAPGSGIGIKPISEKGSKRLVRKAIDYALYKKRPSVTLVHKGNIMKYTEGAFRAWGYELAREEYADRTITEDEAGQGKTGLVIKDRIADAMFQQVLLKPDLYSVIATTNLNGDYLSDALAAQVGGLGLAPGVNMSDRLAFFEATHGTVPSYAGKDVVNPGSLILSGAMLLEHAGWEKASDLIHASIEKVVSSKRVTQDLARQIPDAVTVGCKEFGELIGENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSV7</accession>
    <name>D6SSV7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, MucR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ros/MucR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871122.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1112"/>
    <dbReference type="EnsemblBacteria" id="EFI33773">
        <property type="protein sequence ID" value="EFI33773"/>
        <property type="gene ID" value="Dthio_PD1112"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1797085at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041920">
        <property type="entry name" value="ROS/MUCR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008807">
        <property type="entry name" value="ROS_MUCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05443">
        <property type="entry name" value="ROS_MUCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="15750" checksum="8F45909F5AB0E0FC" modified="2010-08-10" version="1">MEDHVKQALEIVKAQASVRNMTEEEINSMIKSLSEGIQKASQGAAEEQVSEEQHPAVDPKKAIREKSIICLECGKSFKVITKKHLAKHDMTPEEYKEKWGYKKNQSLVAKSLARERRKKMQEMELWKKREIKMPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSX2</accession>
    <name>D6SSX2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD1127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871137.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1127"/>
    <dbReference type="EnsemblBacteria" id="EFI33788">
        <property type="protein sequence ID" value="EFI33788"/>
        <property type="gene ID" value="Dthio_PD1127"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="10">
        <location>
            <begin position="267"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="510" mass="55038" checksum="1B2332F44A268EA7" modified="2010-08-10" version="1">MGKVYLIGAGPGDPGLLTLRARDLLSMADVVVYDYLANEDFLKFCRKDAELIYVGKKGGDHTLSQEGINQLLVDRAGSGNHVARLKGGDPYVFGRGAEEAQELLQAGIDFEIIPGVTSAVAAPAYAGIPLTHRRYASSVSFITGHEDPDKPESAHNWASLATGTSTLVFFMGVKNLQHISHSLIQAGMDPQTPAALVRWGTTCMHRSMVSTIQDIPGQAVDQGFKPPSLLVVGHVVRLRDELNWFEKLPLLGRGVVVTRAREQASGLLEQLRELGACCYEFPTIEIQSLPDYSDVQQAISHLSGYDWLVFTSVNGVLYFWAELERAGLDSRALGGRKVAAIGPATAQALEHRGIRPDFVPDKYVAESVVQGLLDLGVQGKKVLIPRAKVAREVLPQELEKAGADVHVLPVYQTGLAQESGQSILEAMQEGSISYITFTSSSTVENFFSLVQPGEVARHQDQGLRLVCIGPVTAGTLNGFGLEADIVPEDYTIPGLVNVLLEDAGKRGDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSY0</accession>
    <name>D6SSY0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871145.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1135"/>
    <dbReference type="EnsemblBacteria" id="EFI33796">
        <property type="protein sequence ID" value="EFI33796"/>
        <property type="gene ID" value="Dthio_PD1135"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="341" mass="36610" checksum="C578BC61B77D2B29" modified="2010-08-10" version="1">MRIRTSILLVTLAFMLLGMIIASVSMGYVQVPLSTTFQMLFYKITGQQELLLQADPLVYTVIFEVRLPRVLTAAIVGAGLALAGVIFQGLLLNPLADPYTLGVSSGAAFGASLVLLFNLQFLGLYTLPLFAFIAGCLTLLFVVYLSATAGGLSSNNLILSGVIVSAILSAGISLFKYLAQERVSVIIFWLMGSFASSTWPELILTSSMVFLGFMVFMFYSRDINLICLGSRAAASLGVDTTKLRIILLITASLVAAVCVSISGIIGFVGLLVPHMMRSLTGPEHRSLLPVSLLCGAVLLLAADTLTRTMLPAEVPIGVLTALIGGPFFCYIFRKRQMQFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSZ5</accession>
    <name>D6SSZ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871160.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1150"/>
    <dbReference type="EnsemblBacteria" id="EFI33811">
        <property type="protein sequence ID" value="EFI33811"/>
        <property type="gene ID" value="Dthio_PD1150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="100" mass="11904" checksum="A95631D1370C23B8" modified="2010-08-10" version="1">MSIKDFFDREKISPLLKLPDEMREKLFSGTHLSRREKYVMANLYYLDSWNKLDEYQNLLPAMADLELSECLESIDILEEEGFISRKGQKIILRIKPITYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST21</accession>
    <name>D6ST21_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytoplasmic chaperone TorD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871186.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1176"/>
    <dbReference type="EnsemblBacteria" id="EFI33837">
        <property type="protein sequence ID" value="EFI33837"/>
        <property type="gene ID" value="Dthio_PD1176"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1940639at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="220" mass="24772" checksum="A3F4D2E1C57CBEB1" modified="2010-08-10" version="1">MSNDNILPGSITGLDSAGRQQILQAVEHLIQVFWSRDGRKNWEELWENSISVWNGLQGVVFKGTPRIAAYLDEIQSRGQKPETLQELESVFVETFINTHGGVSAPLYHSCYHGEEQLLMQQPALEMQKRLSEAGLEPQNPGEPVDHLCLELEYLYFLMSLYLQDPDPETAAEIADFSGNFMLPWIQEFMQRIPADAPGAAFFANTAEAMQDLLQLLGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST64</accession>
    <name>D6ST64_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC_trans_aux domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1219"/>
    <dbReference type="EnsemblBacteria" id="EFI33880">
        <property type="protein sequence ID" value="EFI33880"/>
        <property type="gene ID" value="Dthio_PD1219"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005586">
        <property type="entry name" value="ABC_trans_aux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03886">
        <property type="entry name" value="ABC_trans_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088199" description="ABC_trans_aux domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_trans_aux" evidence="2">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="251" mass="28512" checksum="5D46C2907384563D" modified="2010-08-10" version="1">MMTNSQKLLLCLLCLLLLAIAACAPKKKPPERNFFVLETKRQAGETWDEPRGILSVRGFDVSPGFRGKEIVYRTERGRSQSDFYNQYFISPGPMLTDVSRQWLDDSGMFEAVISMGSHKEADYILEGSVTSLYGDFQEGDEPASVLRMQFLLLEDDRLDYHMLMHRTYKERVTLTGSGAEHVVQGLNKALTRILTRLEKDMAAAMENRRQSRHPGGFFLKNAPVGLPLLDIGDEELSFYSWMIKTSSTIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST79</accession>
    <name>D6ST79_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="4">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nuoD</name>
        <name evidence="6" type="ORF">Dthio_PD1234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871244.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1234"/>
    <dbReference type="EnsemblBacteria" id="EFI33895">
        <property type="protein sequence ID" value="EFI33895"/>
        <property type="gene ID" value="Dthio_PD1234"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="3 4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="5">
        <location>
            <begin position="140"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="5">
        <location>
            <begin position="312"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="44069" checksum="B594433A3528FC13" modified="2010-08-10" version="1">MNLDLRLDTKGDFYSQRFQPTEREDTLVLNMGPQHPSTHGVLRILLEIDGEYILRAEPVLGYIHRMHEKMAEVMSYPQYLPNPGRTDYLHALAWNWAHVAAVERLMGIEVPERAEYIRVITCELNRISSHLLWWGAILLDLGAFTPIMYAFDDRERIQDIMQRNTGSRLTYCYYRFGGVSADIDDKFIEATRAECARLKDRAKMFKDLVTDNFILRKRMEEVGEIPIDTCRKYGATGPVLRGSGQAYDVRRAEPYSIYNRFDFNIPTYDTCDSMGRYLVRMDEIQESIKIIEQALDTLPEGDYILPKAPKRPKPPAGDVYFALEGARGKIGMHLVSDGGKSPYRLKLRAPGFSNLSLFSEVAQGTLISDAIAILASLDLVIPEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STF0</accession>
    <name>D6STF0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871315.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1305"/>
    <dbReference type="EnsemblBacteria" id="EFI33966">
        <property type="protein sequence ID" value="EFI33966"/>
        <property type="gene ID" value="Dthio_PD1305"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50341XC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="916465at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="28661" checksum="DB28312547F8FFAA" modified="2010-08-10" version="1">MNQFTFPVILVLALILLTPGCGGITELRDRYWPTGPSEYEMKVSDKDMDRLQLELVQNIYPVDTELSMLLRRLSVQDDYPPLQWKENLVQDFPWLNGIAVLDTEKNVQAEHPRDGIKQLEYSPLFPRALELPLGQTMLAVEDTPLGPEILLASAVYRDFEIEGLTVVHFDPRSFIADSADPDEIVIICREKVVWPGQYQDLKEEMNEVEWGELTRKKISGTIEVDNSRFFWFARSVGQDWLIYLLKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6STF5</accession>
    <name>D6STF5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871320.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1310"/>
    <dbReference type="EnsemblBacteria" id="EFI33971">
        <property type="protein sequence ID" value="EFI33971"/>
        <property type="gene ID" value="Dthio_PD1310"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="185"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="412" mass="44282" checksum="3F30A45FA877AB41" modified="2010-08-10" version="1">MDDFFNVLQVEELTRILQQMPALGTQELGLENCRGRFLARDLHAPGDLPATNRCSMDGYAVRAGDTFGAGESNPAYLEKVKDLGICDIPDFSIDQGGCAGVVTGGILPQGADAVVMQEYTEELGAGTVEVRRPVAPWENVMFRGEDVAGGDVAVSAGQRAGFRQTAMMAALGVDKWAFFKTPRVGIISTGDELVDISSPLQAGYIRDVNSYALAHLVRGCGGEATVYGITRDREEDLNKALLRALEKNEVLLVSGGSSVGQRDFTLKAMQGIQGLEVLAHGLAISPGKPTIFARRHDKYIWGLPGQVGSAQVVMLVLVLPFLNHLQGAADAFSEDAKGMVRARLSRNLASSYGRKDYVRVRLQEDEQGLTATPVLGKSGLLKTVFQADGLIWIPSNCEGLARGEEVRVMTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6STH0</accession>
    <name>D6STH0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871335.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33986">
        <property type="protein sequence ID" value="EFI33986"/>
        <property type="gene ID" value="Dthio_PD1325"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1108674at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016907">
        <property type="entry name" value="UCP029033"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029033">
        <property type="entry name" value="UCP029033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="237" mass="26015" checksum="3C11EE2B9347ECFA" modified="2010-08-10" version="1">MRENWTSNFSAGLLIGVALVISSLVLGGAVKDFRSYDRYVSVRGFAEREVPADLAYWPISFSAAGNDLQKIQEELDTSADKVMAFLDRQGLGEAEASISSPRINDQHAFGASPQHLPANRFTAQSVITVRTGDAKAVKEAMSAAGELLSEGVVLVHSYEFQPRFEFTGLAEIKPEMIAEATRDARSAARQFARDSESSVGAIRRASQGLFTINDRDDFTPEIKRVRVVTSVDYFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STJ1</accession>
    <name>D6STJ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1346"/>
    <dbReference type="EnsemblBacteria" id="EFI34007">
        <property type="protein sequence ID" value="EFI34007"/>
        <property type="gene ID" value="Dthio_PD1346"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZJ9Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043707">
        <property type="entry name" value="DUF5647"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18882">
        <property type="entry name" value="DUF5647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10001" checksum="4898D3DBC91215AC" modified="2010-08-10" version="1">MTREELFKKNQQLSTEFELYLLEHPEVEEKIPDNAVLVLLPDYDQELASRNMEIAQVQKEAGQVVVYVRVEKLRKSRIDGLSLKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6STN9</accession>
    <name>D6STN9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Desulfoferrodoxin Dfx domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 2 irons ions per subunit via 4 cysteine residues per iron.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871404.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1394"/>
    <dbReference type="EnsemblBacteria" id="EFI34055">
        <property type="protein sequence ID" value="EFI34055"/>
        <property type="gene ID" value="Dthio_PD1394"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2084237at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00974">
        <property type="entry name" value="DSRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004462">
        <property type="entry name" value="Desulfoferrodoxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038094">
        <property type="entry name" value="Desulfoferrodoxin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012002">
        <property type="entry name" value="Desulforedoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06397">
        <property type="entry name" value="Desulfoferrod_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000075">
        <property type="entry name" value="Desulforedoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00319">
        <property type="entry name" value="desulf_FeS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrod_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000075-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="37" mass="3930" checksum="4D3DCE3981A0D2D6" modified="2010-08-10" version="1">MPETGEIYKCEICGNVVEVKEAGGGELVCCGQPMVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6STP9</accession>
    <name>D6STP9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoenolpyruvate synthase</fullName>
            <ecNumber evidence="5">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871414.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1404"/>
    <dbReference type="EnsemblBacteria" id="EFI34065">
        <property type="protein sequence ID" value="EFI34065"/>
        <property type="gene ID" value="Dthio_PD1404"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="299030at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="9">
        <location>
            <begin position="127"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="9">
        <location>
            <begin position="349"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="8">
        <location>
            <begin position="431"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="797" mass="90680" checksum="25FED3594FF0D301" modified="2010-08-10" version="1">MWLTQLLGYWSRQVFAPGAQLRRKYQYFRDLLAQDRHCLEKMAEIEEIHYRGLHCDYARVARLCRELLRDVDMLVKSLVALNPLRYRVLKDYKKKVSFYVELALDVQSGPDERPWFLNLDSPHASQELLGGKAHNLALISKKGFPVPRGFCITTRAFNHFLNANNLRPRINEILGNICLDSADLEEYSRQLQQLVLDAEIPQDLYLALQDRLQEMPQGRLAFRSSAFGEDSELSFAGQYESLLNVDRENWVQAYKEVLAGKYSPRALSYRIRAGFPDELLSMAVLVLEMLPARESGVIYTSDVNHPEHMGIYTVSGLGDKLVGGEARAREYFLEKDKEPAPSSDHPAYLPDLHRFALELENYFEFPQDIEWVADQQDRVILVQTRPFHSASEGQKGLEPDLPVLCKGQWASPGMAQGPVFRLRSRENISQIPKDVIVVTPGLYPELTAVLDRISAIIALEGSAASHLATIAREEAVPAVINVDKDMPQWEDGLWVTVDGYRGTVHEGRSQAAQSAPTQRQTWMGEKMRSVLKSISTLNLKDAQSEDFIPQNCRSVHDIIRFTHEMGVREMFSLSGSRGKGLGSSRILELEIPMSFRVLDLEEGLHPSAEKQERITLDQVASKPFQALFQGLTWKSIKWDHSTWHFDWQEFDRMSAGIFDPAKSAALSSYALVARDYMHAQIRFGYHFAVVDSLMSSNRDQNYAQFSFKGGGAREEQKILRLEAIKIVLEQFGFTCFIKGDMLSAETAREDEQAIWRSMLVLGYLLGRTRLLDMSMHRLDVNDLARQIIEEIDAALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STS4</accession>
    <name>D6STS4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871439.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1430"/>
    <dbReference type="EnsemblBacteria" id="EFI34090">
        <property type="protein sequence ID" value="EFI34090"/>
        <property type="gene ID" value="Dthio_PD1430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="7965" checksum="A12B465679C80AA2" modified="2010-08-10" version="1">MATTTCPECGRVNDVASLVEFNEYVEGQAVAALCSCGELHDLSPEMETEYWMQRLLDAQMEWSREAHHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6STT3</accession>
    <name>D6STT3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871448.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1439"/>
    <dbReference type="EnsemblBacteria" id="EFI34099">
        <property type="protein sequence ID" value="EFI34099"/>
        <property type="gene ID" value="Dthio_PD1439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="145" mass="16974" checksum="1AFB166EA6E6F6C7" modified="2010-08-10" version="1">MMLLSLQWANPYTQPPAGQDWVLYWSVASKTGLGVGEELIQKAKAEGYDVSGYRLTFTPKAFTQFKPLKPESLASMRYKRLRTKLKKKISMPGFVEEILDWKKDYYDLETCRKQYERKVQINKELEQDLAEKYPPHKYVEIQGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6STX4</accession>
    <name>D6STX4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HicA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871489.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1482"/>
    <dbReference type="EnsemblBacteria" id="EFI34140">
        <property type="protein sequence ID" value="EFI34140"/>
        <property type="gene ID" value="Dthio_PD1482"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50333Z2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9337" checksum="074CB7570A4C7FB7" modified="2010-08-10" version="1">MTRQAKLIKKLQDPKAAWTWDELCALLRGLGYQKLEGSGSRVKFDNGNPGNLINLHRPHPDNQVKAYVIRRIREKLQSGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6STX7</accession>
    <name>D6STX7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871492.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34143">
        <property type="protein sequence ID" value="EFI34143"/>
        <property type="gene ID" value="Dthio_PD1485"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033I4Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2059862at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013406">
        <property type="entry name" value="CHP02574_addiction_mod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09720">
        <property type="entry name" value="Unstab_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8759" checksum="23ADC903F706BCD8" modified="2010-08-10" version="1">MKVAELASEALQLDPHDRALLAEAIWESLEDPFVSGRELSDVESIHLAIRRDEEIERGEVKPLSHSELMSRLHRNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6STZ3</accession>
    <name>D6STZ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1502"/>
    <dbReference type="EnsemblBacteria" id="EFI34159">
        <property type="protein sequence ID" value="EFI34159"/>
        <property type="gene ID" value="Dthio_PD1502"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10923" checksum="678AD3A643D6D723" modified="2010-08-10" version="1">MARRVSAYRFSNTFKKQYQGLPAEIKKSFRTKLALFLEDMDHPSLRIKKIQGTKNRWEGSVTMKYRFTFHVEGDLVVFRAIGTHDILLRESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU17</accession>
    <name>D6SU17_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0423"/>
    <dbReference type="EnsemblBacteria" id="EFI33108">
        <property type="protein sequence ID" value="EFI33108"/>
        <property type="gene ID" value="Dthio_PD0423"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1629654at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011396">
        <property type="entry name" value="UCP030850"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030850">
        <property type="entry name" value="UCP030850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="210"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="36601" checksum="43C03DCAD8A879CF" modified="2010-08-10" version="1">MTSDYLQKLARLRTDANRSRWTEVTAHRAPHKPFLLLSVMDLAAQGELTSPFIEPGFDLIERFARYWDLVRPPSGKCNMAYPFFHMRSEGFWHLVPGPGKENQVHEGITSSITRLKTVVLGAELDPELFQLISEHKSREELRAVVLHTYFAPEVREKLLLEASENQQAYEYSRKLLKAAEKTLPYGSDKPANIRDQGFRKAVMTLYAHRCALCGIRMLTPEGHTIVEAAHIRPWSDTSDDRPANGMALCRLCHWSFDRGFMGVGKEYEVLISPLSRQEHNNPGPIMTLDHRPIFKPSDERHIPDQECLGWHRREVFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU43</accession>
    <name>D6SU43_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871519.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0129"/>
    <dbReference type="EnsemblBacteria" id="EFI32823">
        <property type="protein sequence ID" value="EFI32823"/>
        <property type="gene ID" value="Dthio_PD0129"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2089718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="190" mass="22051" checksum="FFB1CA2EF19294F5" modified="2010-08-10" version="1">MDAKEAMLSAMKEWMLPELNSIREDYKNIKTTLDLTNKRLDDINAHLVDQGRRIDETRAELSSRIDETRAELSSRIDETRAELSSRIDETRAELKAEIQKNTERIDETNKRIDDTNKRIDDTNNRIDNTRAELKAEIQKNTERIDYTNARIDNLAREVAEARGDLNKALRDKVVVQDLVERVGRLETRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU89</accession>
    <name>D6SU89_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0178"/>
    <dbReference type="EnsemblBacteria" id="EFI32869">
        <property type="protein sequence ID" value="EFI32869"/>
        <property type="gene ID" value="Dthio_PD0178"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI32869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="102" mass="11914" checksum="AED2F9DE22C5F1A8" modified="2010-08-10" version="1">MSKTYFAGLDKNVITTYSYKMTKREKLLSRAKNNPKDLTFDEFQTLLRHAGWTFDHQKGSHQIWYSPNRRRLPVQPGKNGKAKGYQVEQFLVALMEETDGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU93</accession>
    <name>D6SU93_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871567.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0184"/>
    <dbReference type="EnsemblBacteria" id="EFI32873">
        <property type="protein sequence ID" value="EFI32873"/>
        <property type="gene ID" value="Dthio_PD0184"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI32873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="7173" checksum="233875242CB8EAE7" modified="2010-08-10" version="1">MSVKRRDLVKYFEQNGFKLLREGANHSIYTNGTKAIPVKRHRQLDRITANELCKQAGLDPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUF2</accession>
    <name>D6SUF2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrite reductase (NAD(P)H)</fullName>
            <ecNumber evidence="8">1.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871625.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0246"/>
    <dbReference type="EnsemblBacteria" id="EFI32932">
        <property type="protein sequence ID" value="EFI32932"/>
        <property type="gene ID" value="Dthio_PD0246"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017220">
        <property type="entry name" value="Sulphite_reductase_assimil"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037487">
        <property type="entry name" value="Sulfite_red_assimil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="7">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="6">
        <location>
            <begin position="84"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="220" mass="23672" checksum="325BF6B47A7F0DBB" modified="2010-08-10" version="1">MLKDGEKGAILQNDKKTYAIAPHLPCGVVSPDTLRRIADVAEKYNCAALKVTSAARIAMVGLKEEDIDAAWEDLGIPPGAAVGVCVRSVKACPGTTFCRLGQQDSLNVGLELDKKYHGRELPGKLKFGVSGCPHQCAETCIKDIALVGKKKGWTLLTGGSGAGKPRLADEIASELETDQIMQMVEKVIEVYTAQAKKHERMGKMMDRIGVDSFKQMVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUJ4</accession>
    <name>D6SUJ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871667.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0288"/>
    <dbReference type="EnsemblBacteria" id="EFI32974">
        <property type="protein sequence ID" value="EFI32974"/>
        <property type="gene ID" value="Dthio_PD0288"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCR7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902499at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15643" checksum="7C4CB0DC48F0F22F" modified="2010-08-10" version="1">MLYRNIYCATQKKISGSYYTTPIRCVRYCRYFPCSFFTQDDIEGYISRELIAREFTGFKIRRTKMYLFKKNDGSLVEAPEDFDPKEPDWNSMQEVEEVLVISKILVPQMKLVPKTQGSAEKNSSGTAAKPPKTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUL2</accession>
    <name>D6SUL2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">Dthio_PD0306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871685.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0306"/>
    <dbReference type="EnsemblBacteria" id="EFI32992">
        <property type="protein sequence ID" value="EFI32992"/>
        <property type="gene ID" value="Dthio_PD0306"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="17"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI32992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="28364" checksum="3E782EDCD816CF0C" modified="2010-08-10" version="1">MKKFRGIFLKNDHEISLLREANQIVARILDDIESRIRPGITTMDLEERANELCAQYQVKPAFKGYQGFPYTLCCSLNDVIVHGFPTLDELKSGDILSIDMGVQYRGFFGDSARTFAVGDISSEAGRLMQVTMDALYKGIQQARAGNDLYDISAAIEMHAKKNACSIIKRFVGHGIGASLHEKPELPNFVPSRMLGVPLKKGMVLAIEPMFSLGSEQVEIMPDNWTARTADRSLAAHFEHTVAITKDGPEILSTLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUM4</accession>
    <name>D6SUM4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">Dthio_PD0318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871697.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0318"/>
    <dbReference type="EnsemblBacteria" id="EFI33004">
        <property type="protein sequence ID" value="EFI33004"/>
        <property type="gene ID" value="Dthio_PD0318"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10448" checksum="969E3C36BD2EC9BE" modified="2010-08-10" version="1">MTSKTKASGSKRRMVGFVISDKNDKTIVVRVETLIKHPLLKKYIRRRKKFMAHDPENDSKIGDKVQIIEHRPLSARKKWHLNKVLERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUX0</accession>
    <name>D6SUX0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871825.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0009"/>
    <dbReference type="EnsemblBacteria" id="EFI32726">
        <property type="protein sequence ID" value="EFI32726"/>
        <property type="gene ID" value="Dthio_PD0009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="121" mass="14025" checksum="D9D8A20F442865B3" modified="2010-08-10" version="1">MGKEKLVTLLEMAEEIDVNYRTLISCKRELSEFVFGTSEGRLMKYAPEYTDFFVLIFALKDQGYTVDQIRMMLNGDIPDNIDNKLIEWVTIWKNRIKAAYLQMDGLTDGWMDGLRDEGING</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV27</accession>
    <name>D6SV27_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871873.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0080"/>
    <dbReference type="EnsemblBacteria" id="EFI32783">
        <property type="protein sequence ID" value="EFI32783"/>
        <property type="gene ID" value="Dthio_PD0080"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="118"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="338" mass="39759" checksum="9A431B6F55682619" modified="2010-08-10" version="1">MNLGSCLHTFFDQYLPRTKGVSSNTILAYRHTFSLFLPFASKTLGRDINSLEIEHLSTQLILDFLDHLESDRNNSARTRGHRLAVFKSLARMIRFLYPEHKLLADRIISIPQKRFPKKLAAFLTHEEVLLVLDSINLKKSGAFRDYTIIHLLYNSGARAEESASLRLDYFDPHKKTLAILGKGNRYRQIELWPKTVQLMSMYIQKYRPRPKPLHQNTLFLNQRRQGFTRNGIYRLCRKYLSLVFEENRFQGLNPVHCFRHSCAINMLGTGFSLTDIKNHLGHENLQSTMVYLKLSLNRKRELQQKFIEYTQNQTQDPKLDELLDWEKEQETLDWLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV59</accession>
    <name>D6SV59_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0117"/>
    <dbReference type="EnsemblBacteria" id="EFI32815">
        <property type="protein sequence ID" value="EFI32815"/>
        <property type="gene ID" value="Dthio_PD0117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="14213" checksum="CED7BF7429F16A55" modified="2010-08-10" version="1">MSITLNQTLLTKRFEGHFVFSDEYPKQIRKRINQGLSTLKKYPNLEEAKEEIVKLNHKPVTIMDRTFTPMEGLTGFINELQACYEHYHENTGALRMLWNALTGKTPWIYPDYEVGKGCKPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJQ8</accession>
    <name>D6SJQ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869236.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3563"/>
    <dbReference type="EnsemblBacteria" id="EFI36111">
        <property type="protein sequence ID" value="EFI36111"/>
        <property type="gene ID" value="Dthio_PD3563"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBF5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661416at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014858">
        <property type="entry name" value="BrxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08747">
        <property type="entry name" value="DUF1788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="184" mass="21296" checksum="619FE91563D16A79" modified="2010-08-10" version="1">MSRTKQLIEVYSNYISIPWRRDEAPAQRIIFCVYNEAEELKIRARIDEFELATRQAGHDWYLFDLTESFACWMLSQKYAGKYFQNPDLLKTLLPENYQQHITRSFAEFYEKNNIDDNSVVTLMGVGSLFGFSKVRDVVDSLSSIVAGRLVVLFPGSYENNNYRLLDGYDGWNYLAVPLTADASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK37</accession>
    <name>D6SK37_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869362.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3697"/>
    <dbReference type="EnsemblBacteria" id="EFI36240">
        <property type="protein sequence ID" value="EFI36240"/>
        <property type="gene ID" value="Dthio_PD3697"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2092219at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8384" checksum="68F8EE76E96C0821" modified="2010-08-10" version="1">MQNIDTILDQAMALPYETRLDLIRIIKKRTMEEERIRIAEECRNVEQEYAVGSIKSGSVQDLMYYLENDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK52</accession>
    <name>D6SK52_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869374.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3715"/>
    <dbReference type="EnsemblBacteria" id="EFI36255">
        <property type="protein sequence ID" value="EFI36255"/>
        <property type="gene ID" value="Dthio_PD3715"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="176"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="43843" checksum="F54CE8916D56DFC6" modified="2010-08-10" version="1">MIARNNEINLLLEALATYPAVGIIGARQVGKTTLAAMLTRKWSGPVHHFDLENSEDMARLFDPMLTLKELRGLVILDEIQRMPEIFPALRVLIDKKLDDLRFLILGSASPQMLRQSSESLAGRIRYHRLSGLGLDEIPSGQSEQLWLRGGFPLSFLAQDDAKSFEWRKAFVSTFLERDLPQLGINVSSTTLRRFWNMLAHYHGQIWNASEFARSFGVADTTVRQYLDRLTDALVVRQVQPWHENISKRQVKSPKVFICDSGLTHALLNLPAKHDVLGHPKSGATWEGFVIEQIIRLLRADESECFHWATHSGAKLDFLHVRGSTRTGFEIKRTSSPRLTRSMRIAMHDLKLKHLFVIHAGEHIFPLAENIKAVPISRLSETLMGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK72</accession>
    <name>D6SK72_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsO</name>
        <name evidence="8" type="ORF">Dthio_PD3738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 7">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869394.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3738"/>
    <dbReference type="EnsemblBacteria" id="EFI36275">
        <property type="protein sequence ID" value="EFI36275"/>
        <property type="gene ID" value="Dthio_PD3738"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10679" checksum="09F5D1D5521A2044" modified="2010-08-10" version="1">MVMEPKDKSKIIEEFKQHENDTGSPEVQVALLTERIKYLTEHFKTHKKDFHSRTGLLKLVGKRRKLLTYLKEKNVERYRQLISRLGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKB0</accession>
    <name>D6SKB0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, MucR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ros/MucR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869432.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3777"/>
    <dbReference type="EnsemblBacteria" id="EFI36313">
        <property type="protein sequence ID" value="EFI36313"/>
        <property type="gene ID" value="Dthio_PD3777"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1797085at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041920">
        <property type="entry name" value="ROS/MUCR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008807">
        <property type="entry name" value="ROS_MUCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05443">
        <property type="entry name" value="ROS_MUCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="139" mass="16137" checksum="300E1AB92ABFA4A7" modified="2010-08-10" version="1">MEDHVKQALEIVKAQASVRNMTEEEINSMIKSLSEGIQKASQEVAEPQAEQEQQPATDPKKAIREKSILCLECGKSFKVLTKKHFAKHDMTTEEYKEKWGYKKNQSLVCKSLARERKKKMQEMELWKKREMKPKGKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKC5</accession>
    <name>D6SKC5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG domain protein DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869447.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36328">
        <property type="protein sequence ID" value="EFI36328"/>
        <property type="gene ID" value="Dthio_PD3794"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1950900at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9814" checksum="C07C80989A4ADAF8" modified="2010-08-10" version="1">MRSVKTAISIEKPLFEEIDNLADEMNMSRSRVFSLAAKEFIQRHKNKDLLDAINSAYGDVTDEKEASLKTVMRSRHRNMVRDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKE2</accession>
    <name>D6SKE2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding S1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3813"/>
    <dbReference type="EnsemblBacteria" id="EFI36345">
        <property type="protein sequence ID" value="EFI36345"/>
        <property type="gene ID" value="Dthio_PD3813"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="109"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="197"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="286"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="373"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="476" mass="52345" checksum="3E4307E276C6F6BC" modified="2010-08-10" version="1">MEERDEEQSFARMLAESEMESGPELEPGDRVRGKIISIGKDHVYVDTGTKTDGVADREDLLDSEGNLALEEGDSVELFVVSRHQGEIRLASSFGAHGGVQQLMQAMEQEIPVQGKVKETCKGGFRVQVMGNHLAFCPMSQMDNRMVEDSQSLVGESMTFLVSRVEANGRNIVVSRRALKDKEQAESLHEFSRNYKPGDVLQGTVTRVEPYGVFVEVAPGLEGLVHISEMSWSRSLAPEEIVSVGDTVSVHLLGIEEKDKGQVRIGLSMKQAQADPWESITENFEPGSVVEGVVTRVAPFGAFVEISPGLEGLVHVSEMSYLKRVSKPEEEVQPGQKVRVKVKGIDSLERRISLSMRDAQGDPWEGVSTRYEKGTLVEGKMEKQEDFGMLVALEPGVVGLVPRSILHQNQDSSLTNKKPGDRVNVAVESVDEANRRISLQPADSVQSEEWQSYAPARDNGLGSLGLELKKAMEKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKI7</accession>
    <name>D6SKI7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35198">
        <property type="protein sequence ID" value="EFI35198"/>
        <property type="gene ID" value="Dthio_PD2606"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="8312" checksum="4978EFF55DC08478" modified="2010-08-10" version="1">MSSLHYPEKRDKIHEALELLFKGLGAKEAHEIFAILIKYLLIATDETPEEAEEKVKHLPRGGETVRTTAEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKP0</accession>
    <name>D6SKP0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868384.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2662"/>
    <dbReference type="EnsemblBacteria" id="EFI35251">
        <property type="protein sequence ID" value="EFI35251"/>
        <property type="gene ID" value="Dthio_PD2662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088092" evidence="1">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="156" mass="17990" checksum="7D7D70F4CFAB93D6" modified="2010-08-10" version="1">MFKWIISLSCLGLFCTMLVLAGDSHRQVQSARDRIESLQTAKGELLRLDEKHQEKQKRAEQWNIFWEQAVEAGLHPDKWQAYPVNIEDTLTLNEAENILTILSSKMNESDSFWFSPGSVRVIPEIDSGENREDMEVLVEMHIQGKIMTMIPESARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKT8</accession>
    <name>D6SKT8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2713"/>
    <dbReference type="EnsemblBacteria" id="EFI35299">
        <property type="protein sequence ID" value="EFI35299"/>
        <property type="gene ID" value="Dthio_PD2713"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="449" mass="49265" checksum="90AEC92743CE1E00" modified="2010-08-10" version="1">MIILDTALKKRQQENNPVRVGVIGAGYMGRGTVFQAERAVPGMRVSSVYNRHIDEAARAYEQAGINDFSIVETKSQLEDAIVKNRYSITENPELICQAQGIEAVIEATGEIDFAAKLCLIAMEHGKHIILMNAELDATLGPILKIYADRAGVVFSNADGDQPGVLMNLMRYVQTIGCRPVLAGNVKGLHDPYRTPETQKGYARKYHQKPRMVTSFADGTKISFEMAVVANATGFKAGQRGMYGPACAHVSQSAPLFPLDQMLDTGLVDYVLGAEPPGVFVLGYNDEPLTRQYMDYYKMGTGPVYVFYTPYHLPSIEAPLTAARAVLFKDPAITPMAGPVCEVVTTAKRGLKSGDVLDGIGGFDTYGVLENTPVAMEQNLLPMGLAGDCRLKRDIKKDQVITYNDVQVPAGRVGDMLKNEQLIYFTDRKTAHHRSVSDWKSLSLDERCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKU0</accession>
    <name>D6SKU0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35301">
        <property type="protein sequence ID" value="EFI35301"/>
        <property type="gene ID" value="Dthio_PD2715"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13701">
        <property type="entry name" value="DDE_Tnp_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="32"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="375" mass="42678" checksum="1BFD5D69E125D0A8" modified="2010-08-10" version="1">MQLFCNCTQQVKEAIILKISKVVNKDDLQTGPAGLILLGEMVRAVELDKIAKAITSGNPQITAADILKTMIGLLSQGKSDFDHAKAIIGDEFFMNSMGIDRVPSAETYRQKFQELALNNDLETILPELSIKLWKKSGVENEYIEKDQKKWVRVDIDPVIYDNADTKKEGAAYTYNNQFGFSPVFAHFAGGWMINAKLYPGNFSTHSPEAMDFVLQSLGFKDRMVEETKLLVMDCGFDNQQMLQNLWNRTNTDFLVKHNIRRESPESWLEVAKEKGELVFSDEKKGYDLYRGSTYRHIDGCDEPVRLVFEVREIFKKKGQLLLMPQAKVFSVWTSLDQAFSDKEVLKLYRMRGITPHGVMNTAFLLMGMLTCHAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKV7</accession>
    <name>D6SKV7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase involved in chromosome partitioning-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868450.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2733"/>
    <dbReference type="EnsemblBacteria" id="EFI35318">
        <property type="protein sequence ID" value="EFI35318"/>
        <property type="gene ID" value="Dthio_PD2733"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="211" mass="23514" checksum="7A012AACB986F93F" modified="2010-08-10" version="1">MLEKIMQLTELKRIVPALTQGADPMFPGHFVVTSSLAGEGKSLVASGVAVQMASNSSSRVLLVDFNWRSPVLHRHFGRDQDFDYQKLQGSSNPMNLVQKTDYKELDLLPAPRTEKNDRFPDGQELCVDILKKAREQYQNVIVDTGPLFPENRFMLDPLRLGQSAIGTLLVYLAGVTPRSIAKKSVAMFREHDIGLTGVLMNDYQNPLAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKZ5</accession>
    <name>D6SKZ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">Dthio_PD2771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868488.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2771"/>
    <dbReference type="EnsemblBacteria" id="EFI35356">
        <property type="protein sequence ID" value="EFI35356"/>
        <property type="gene ID" value="Dthio_PD2771"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="445" mass="47587" checksum="6425EEA5429A27C0" modified="2010-08-10" version="1">MHKTITLKAPPSKSVSHRALLAAGLAGGTSVLENVLVSEDILRTRDCLAALGAKFSGDDSTPVVQGLGGRIKAPSLDPVKLDVGESGTTCRLLAAIVSAGQGSFEISGAGRMHERPIKSLGQSLEGQGVRFKYLGLDGCPPVRIESSGLPGGVVTVGLDESSQYLSGILLASTMATTSLVINIGGKKVVSWPYVHLTLQTMQRFGNPARLQTLQEGHWRHADPDQVQRVEPGKIRFVVHPGVLNPVRYRVEGDYSNASYLLAAGAVGEFPVEVSGLDLESRQGDRRILEILELMGAKISETKNGVMVSPARLHGVDLDMGTCPDLVPTVAVVASMATGTTRISNVAHLRIKESDRLAGVQQEVSRAGCRCGLKEDGLEIEPAELLRGSQVQFKTYGDHRMAMSLSLYELAGIQTALDNPACVNKSFPGFWEEWENIRRAYAGKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL20</accession>
    <name>D6SL20_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868513.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2797"/>
    <dbReference type="EnsemblBacteria" id="EFI35381">
        <property type="protein sequence ID" value="EFI35381"/>
        <property type="gene ID" value="Dthio_PD2797"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2006350at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="124" mass="14316" checksum="C3EE088A96E1821A" modified="2010-08-10" version="1">MSDSPLDTLEDKLSEQAERIRELEKKADKILEESYDLDQHRSLLEQKAQILAGLPETAEPFLDQLSHQTRSAVEQRLNTFAHNAQQAMGVGSVFFMRQLLYPEDYREGQANDLESFIQALKQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL78</accession>
    <name>D6SL78_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868571.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2859"/>
    <dbReference type="EnsemblBacteria" id="EFI35439">
        <property type="protein sequence ID" value="EFI35439"/>
        <property type="gene ID" value="Dthio_PD2859"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="17"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="462" mass="52397" checksum="EC00083B6D8B74BA" modified="2010-08-10" version="1">MYRHHLQFLDSWLKDSRRKPLVIRGARQVGKSTLVQLFAKEYGKDLLELNLERYPELSEIFNTKDPDHIIQQIEFLPGMKQVSQNSLLFLDEIQSVPEAIPALRYFYEDKPWLPVLSAGSLLEFVLSDHSFSMPVGRIQYLHMGPMTFSEFLMGIGEEKLGSFILNYEPGQSIGEIVHGRLLSLLRSYYFVGGMPEAVSVFAATKSYKQVSRVHNSVLETYLEDFPKYIGSRNLNRMRRVFHFIARNVGRKIKYSNISFEDQSGTLKKDIDLLSMARVIGKVIRSHCSGLPLHADIDEKVYKPLFLDVGLMNAVCGLDWRAVSQMDDAQLINEGAIAEQFAGQHLQNMFSDALNQELTYWLRQGRSSNAELDFVVQTGGHIIPVEVKAGAAGSLKSLHQFMGSKEAPLAVRLDASFPSVTRIDTKISTGKTFRRVQYPLLSLPLYLIERLGTVAAYYCENQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL97</accession>
    <name>D6SL97_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868590.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2878"/>
    <dbReference type="EnsemblBacteria" id="EFI35458">
        <property type="protein sequence ID" value="EFI35458"/>
        <property type="gene ID" value="Dthio_PD2878"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="216" mass="23919" checksum="439DDFB06B1B295D" modified="2010-08-10" version="1">MSNKGIIFDLDGTLLNTLQDLADTVNSVLKGRGWSTHPVDAYRNFVGDGLTMLIRRAVPEDVQDQSVINECILAAREEYSRRWANRTAPYPGVLEALEELARNEIPMAVLSNKPHEATLHTVGHFFPDGYFQVVQGALPNGAVKPDPEPALEVAARMGLKPDQVYFLGDSNVDMYTALRAKMTALGAAWGFRGREELLQAGAHYILESPQELSEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLB7</accession>
    <name>D6SLB7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868610.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2899"/>
    <dbReference type="EnsemblBacteria" id="EFI35478">
        <property type="protein sequence ID" value="EFI35478"/>
        <property type="gene ID" value="Dthio_PD2899"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2100386at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="7149" checksum="0BC035FF5DDD5254" modified="2010-08-10" version="1">MAEKGDDPQTKALTWDEVSYSNMIQHEALISLLLEKGVITEEEYLDKVRQVTRELQDRQAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLE2</accession>
    <name>D6SLE2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868635.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2927"/>
    <dbReference type="EnsemblBacteria" id="EFI35503">
        <property type="protein sequence ID" value="EFI35503"/>
        <property type="gene ID" value="Dthio_PD2927"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="136"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="469" mass="51691" checksum="98396760DC4E51D2" modified="2010-08-10" version="1">MPRVLVVDDDPEVQSTMASLLSRQDIPHHLAKDLVSTKQALQEDCFDLVLLDVGLPDGNGLDLLPEIKALKNAPEVIILTGRGDSEGAELAIEGGVWDYLLKPSPIKEIKLSISRALKYRQQKESARPRALDLSGVVGSSPAMQSCYDLLACAAGSDSNILITGETGVGKELMARTIHANSSRSGHPFVVVDCAGITDSLVESTLFGHCRGAFTGALADHTGLISQAHQGTLFLDELGELPLLIQKSLLRVLQERKFRPVGSSREQKSDFRLMAATNRDLEGMVSEGTFRNDLYFRIKTMHMHLPPLRDRVQDIRPLAMHFADELCTRSGIASKGLGADFLETLEAYSWPGNVRELCNVIEQALVACAGETNLYSMHLPKEIRIKVTRSRLEKCPPDESSHGTPPWAQKGDSPPMPDISDFKSYKQECEKKYLQCLLQKYPGNVPAILRLSGLSRSHFYTLLKKYGLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLK0</accession>
    <name>D6SLK0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868693.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2987"/>
    <dbReference type="EnsemblBacteria" id="EFI35561">
        <property type="protein sequence ID" value="EFI35561"/>
        <property type="gene ID" value="Dthio_PD2987"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="134" mass="15135" checksum="EB3487F562557857" modified="2010-08-10" version="1">MKKVGPKIRALREELGLNQKEFGKLVLVDHNTESKWEQREEVPGGAHKKKVEFLLQVGEHQELKEVIKETIESDGGISAAAGLVGMLFGIANAQGISVNNLWQQLSFDSYLMVGINKLKQRRMNEKPPENRRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLQ7</accession>
    <name>D6SLQ7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">3-deoxy-D-manno-octulosonic acid transferase</fullName>
            <shortName evidence="9">Kdo transferase</shortName>
            <ecNumber evidence="3 9">2.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 9">Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD3047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2-&gt;6)-lipid IVA + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28066"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58603"/>
            <dbReference type="ChEBI" id="CHEBI:60364"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.4.99.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.12" evidence="3 9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868747.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3047"/>
    <dbReference type="EnsemblBacteria" id="EFI35618">
        <property type="protein sequence ID" value="EFI35618"/>
        <property type="gene ID" value="Dthio_PD3047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1163086at2"/>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043842">
        <property type="term" value="F:Kdo transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007507">
        <property type="entry name" value="Glycos_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038107">
        <property type="entry name" value="Glycos_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039901">
        <property type="entry name" value="Kdotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42755">
        <property type="entry name" value="PTHR42755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04413">
        <property type="entry name" value="Glycos_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_N" evidence="10">
        <location>
            <begin position="41"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="47241" checksum="1A21FC86489E1FD6" modified="2010-08-10" version="1">MKTRKISFCHWALLVLYSLLWVIALPILLIVRRETPIDSGRLGFGMPRGPFRVWIQAASVGEARLAAALVRELNRKGIRNILVTTNTRQGMDFLDSEIKEDAQKAYFPFDNMCIMAMALCRARPEKLVLLETEIWPSLLNACRRKNVPVVLGNGRLSLKSFCRYYPLRRFLASIGPDRIAAVSERDRERFSSLFPSAQTSVMSNIKFDLLVDKEPMAYVQNPLSSFFKPKHALIALGSVRREEEPQIARVIQKLYSARPKTTIALFPRHMTRIRPWQKILDSEGVPYTLRSSLESGTAPAGVILWDSFGELEAAYAMARSVFVGGSLMPCGGQNFLEALGQGVVPCVGPFWDNFTWVGREIVHAGLLIQVRDKNELSSKLQQPQSMSREQVEKKFKEYLQSRRGGTQELAGIVARHGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLR4</accession>
    <name>D6SLR4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868754.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3054"/>
    <dbReference type="EnsemblBacteria" id="EFI35625">
        <property type="protein sequence ID" value="EFI35625"/>
        <property type="gene ID" value="Dthio_PD3054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="7710" checksum="4BDE167A5E4C72F8" modified="2010-08-10" version="1">MDDPSILVFVLVSFVIGFLCGLLPYLVGSVYGMRRHAKAGMILCIVGGLLGGIVVALPVALIFTGVILFKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLT6</accession>
    <name>D6SLT6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3076"/>
    <dbReference type="EnsemblBacteria" id="EFI35647">
        <property type="protein sequence ID" value="EFI35647"/>
        <property type="gene ID" value="Dthio_PD3076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="51" mass="5779" checksum="19B1840A5881ED3D" modified="2010-08-10" version="1">MGKMAWSMGHGKEVCRYGSIGVWEWEKAVFGCGNLGFLEYVNLDFEMETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLX1</accession>
    <name>D6SLX1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit</fullName>
            <ecNumber evidence="8">4.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868811.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3111"/>
    <dbReference type="EnsemblBacteria" id="EFI35682">
        <property type="protein sequence ID" value="EFI35682"/>
        <property type="gene ID" value="Dthio_PD3111"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="972093at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="278" mass="29813" checksum="3FD18D5C9E7E63CF" modified="2010-08-10" version="1">MRSIDAREVTRQVSQMVVEANMVLPGDVSTALEKAWENEDNPSGREILGQLLENARLAREMSLPLCQDTGLAVFFVELGQECRLRGDLYQAVNAGVSRGYEEGFLRKSVCNPLSRKNTGDNTPAVIHLDLVPGDRLKIRFMPKGGGSENMSGLAMLTPSQGLEGVKEFVLQRVAGAGPNPCPPGIIGIGIGGSFDQAPLLAKKALFRPLDDIHPEQEVRDLEAELFEAVNALGIGPMGMGGRTTCLGVKIQAAPCHIASLPVAVNIQCHAARHKEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLY0</accession>
    <name>D6SLY0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868820.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3120"/>
    <dbReference type="EnsemblBacteria" id="EFI35691">
        <property type="protein sequence ID" value="EFI35691"/>
        <property type="gene ID" value="Dthio_PD3120"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="112"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="312" mass="35484" checksum="EAD0FBC7418E7D93" modified="2010-08-10" version="1">MKTWLTSILICPACLPLEKGLQLKADSQEDDDVLEGTLNCPECLKEYPIREGIAMVHPQQDTIKDSGSKYENSSVVSSYLWSHYCDLLEDPEGSSAYKDWAEQMHADTGGCLDMGSAVGRFTFDMASRFDFALGIDNSVAFIRAARELMTRRQVQFELVQEGILSRKETLTLPDEWQTRNIEFIVADAMALPFATGTFSALASLNMVDKLPLPLKHLQEAGRLAHRKKAQFLLSDPFSWSEQSADRQYWLGGKPEGDFAGYGLDNIAKWLERPRDNPGPGWNIEKKGHVWWKIRTHRNHYELIRSCYVKAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM10</accession>
    <name>D6SM10_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3150"/>
    <dbReference type="EnsemblBacteria" id="EFI35721">
        <property type="protein sequence ID" value="EFI35721"/>
        <property type="gene ID" value="Dthio_PD3150"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4115" evidence="1">
        <location>
            <begin position="223"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="297" mass="33945" checksum="5EB32DDC9D18A129" modified="2010-08-10" version="1">MEMQELGRKLYEERTRRGLSLEQVQDETKISLNFLKALEDGDVEQLPHPVYAKGFMQNYARFLGLDWQSMGEEFSKIYHAEEETESLEELPTVLKEQKEARLFSYTVKASVIILALVIIVGFGWFLYSSFQEEPAQEEQAELAEEIPEYDHVQEEPLEDDILEDRAVTPEEPEIPGDAVPQEDVLLREDVDELQPRVTQLDLEAFAVEPDEPEEEEIPDTVLVHIEAHEECWLMYETDDESRDHFLRPGDSIEVEYTGSMSLRLGNAGGVSISLNGEPYDLDAASGEVKTLEFNDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM24</accession>
    <name>D6SM24_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ORF">Dthio_PD3164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868864.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3164"/>
    <dbReference type="EnsemblBacteria" id="EFI35735">
        <property type="protein sequence ID" value="EFI35735"/>
        <property type="gene ID" value="Dthio_PD3164"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1165356at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="15"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="273"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="374" mass="42295" checksum="6CEA72796B253E6C" modified="2010-08-10" version="1">MNSIGRFRLEHTDGQARCGCLQTLHGEVPTPVFMPVGTQGSVKSLCPMDLDNMGAGMILGNTYHLYLRPGDELLAQMGGLHRFMNWKGPILTDSGGFQVFSLSDLRKITPEGVEFKSHLDGSRHFFTPEKVIRIQKNIGSDIMMVLDECVPYGADLEYTRNSMHRTVQWAWKSRDFYSGETGKQLMFAIVQGGFFMDLRRESAARTCEIPMDGYAIGGVSVGETKQEMLDTVYFTAPLLPRDRPRYLMGVGKPLDILEGINAGLDMFDCVLPTRNARNGTLFTSSGKVNIKQARYRNDETALDPGCDCYTCMNFSRAYLRHLYMAGELLSFRLNTIHNLRFFINLARKARSAIQEKRFAQLISRYRNVEKEQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM52</accession>
    <name>D6SM52_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG domain protein DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868892.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3194"/>
    <dbReference type="EnsemblBacteria" id="EFI35763">
        <property type="protein sequence ID" value="EFI35763"/>
        <property type="gene ID" value="Dthio_PD3194"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046257">
        <property type="entry name" value="DUF6290"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19807">
        <property type="entry name" value="DUF6290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8842" checksum="20AEFDF82EBF85AC" modified="2010-08-10" version="1">MPTSIRIPDDINRRLTELAEATGRTKAYYIKEALNEYLEDLEDIYLAQKRSEDLRAGRSETYSLEEVGRELGFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM64</accession>
    <name>D6SM64_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868904.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3210"/>
    <dbReference type="EnsemblBacteria" id="EFI35775">
        <property type="protein sequence ID" value="EFI35775"/>
        <property type="gene ID" value="Dthio_PD3210"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016418at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9091" checksum="CB3BC6EA657A611E" modified="2010-08-10" version="1">MAASKIAITIDDKTLKRLDLLVKSKVYPNRSNAIQQAVAEKLQRIDKSRLARECAKLDPGVEQSSAEEGFAWELEEWPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMK0</accession>
    <name>D6SMK0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3351"/>
    <dbReference type="EnsemblBacteria" id="EFI35911">
        <property type="protein sequence ID" value="EFI35911"/>
        <property type="gene ID" value="Dthio_PD3351"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029150">
        <property type="entry name" value="dCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14827">
        <property type="entry name" value="dCache_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="359"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="403"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="576"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="689" mass="75469" checksum="1D163FB63614B73B" modified="2010-08-10" version="1">MNFFRNLRLSFKVFIPLTIILIVFIGVLFWVLNDQTQKVSDEFISQISKNKRAEIESSVDLTIQEAQSVASTFSRLPEVIQAYNLALEGNINDPESPESQEAREMLREKLSAQMEGYQEFSDQQLTLHFHLPNGRSLVRLWRDHNAMQDGEWVDISDDISEFRATVMHVNQQQEPAQGIEVGRGGFTLRNVLPVSDQNSDHLGSVELLMDFEPIVEAAGAAAGEEVMIYMNRELLDIATGLQDESQFPLIDNRYVEAIGDSRYSDLITADLLDMGREELSLVQEGHYALSFFPIKDYAGNQVGVTAYILDISDEQGMISQMTQILMGVTAGLLVILLLVVRFVMGWAVLSPFSKGVGFAQQISQGDLTQRLDIKQRDEVGILADALNDMADSLRNMFGDINSGVETLASSSTELNAISEDMSQRSETTASKVQGVASAAEELSTSMSSIASAMEQASSKVNTVATSSEEMGATISEIAQNTENAKDITGNAVEKSRQSSQRIDRLGNAAQEISKVTDTITAISSQTNLLALNATIEAARAGEAGKGFAVVANEIKELAQQTAQATEEIRDKVENIQSETSLTVEEIQEISQIISDIDSIISTIAASVEEQNIATQEIAENVSQASQGNQQVNENVSQVSSVAEDVARDISEVNMDTEEMKSSGVQVKQSSEELSRLAERLKELVSKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMT5</accession>
    <name>D6SMT5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869124.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3438"/>
    <dbReference type="EnsemblBacteria" id="EFI35996">
        <property type="protein sequence ID" value="EFI35996"/>
        <property type="gene ID" value="Dthio_PD3438"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="252" mass="28019" checksum="9DBE8F51DB78E8F8" modified="2010-08-10" version="1">MNENAIEIQDLSFAYNHHPVLEDVNMQVKQAEFLAVLGPNGGGKTTLMRILLGILQPSRGIIRVLGKPPGALPHLVGYVPQSQSGADKFPITVHETVLVGRLGHLGRWRRFTARDSDLARQALEQVGMQDFSGRNIGSLSGGQRQRVLIARALVARPQILFLDEPTAAVDQAFHTRFYDLLKELNDRGTTILVISHDLSVLSSHVKAVACVNRSLYYHDAAEISKEMLEKVYHCPVELITHGDVPHRVLRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMV4</accession>
    <name>D6SMV4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3457"/>
    <dbReference type="EnsemblBacteria" id="EFI36015">
        <property type="protein sequence ID" value="EFI36015"/>
        <property type="gene ID" value="Dthio_PD3457"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="694" mass="81080" checksum="29875A1A6B6C71D3" modified="2010-08-10" version="1">MRSLPFSDVVPKGPLFLRRVAEKTQYLFSKQTPSFSKYIYLYLSGLITMHKTRFIIALLLLFFIAACAEKKVVTDPPRPDLQQRAAQAWEAEDHPAAQDLYSQLLEEFELEEDHEIMAWKRLAVSAGENRDYRQSMQALEKWAQMDPEAADKWKWHHYYSMALKETETEQKYVRYLQNLYRDESRPVELRLKTALTLAEHHLESQRYPEGMDVLRDIRQFAYTDEQKVWIEEAGSRLFLKMDLEELEKAAEFMDREKKLHFPDNLFWWSYFHARLQDDNDQWESLRPGMIEIARQSELVYRTPFNKVLEKWEEKLGKPTPVMALLLPLSDSYSSVGWKVMRGAGQAHWDLLSNGLDVRVKTINTNNPGWIEELKKLQNVSLAGGPLSGEAWEKIREADLHREMVFLTFLPTMEEEGSQGWRFFSSAGDQVRALLKIGTQEMDIENFAVMYPEEDFGRSYAETFWEKARDMDAQVQGIQSYPTDDHASWNRIVSSFLDITDPNDPFLDPDPGFEAVFIPDTLSRAQGLIPQFFYFNVDHLVFMGPMLWYQGYSPGTLEQQFFSLALSCGAWNSHNPSPPARQLSEGLEDSLQGEADFWVALGYDFVRFASRLGNMPSPENNDEVNRILSGNEFDSWSMAPINWDDEGKASQDLFVFRMDRHELQPVEPEAMKWTIESRKQRRAMWLERLREQERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMX3</accession>
    <name>D6SMX3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3476"/>
    <dbReference type="EnsemblBacteria" id="EFI36034">
        <property type="protein sequence ID" value="EFI36034"/>
        <property type="gene ID" value="Dthio_PD3476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11253" checksum="DBB7423F2072E9C7" modified="2010-08-10" version="1">MDIPVLCILEHNPHKHRLALNHGIQTVKRVPTFNMCLDRFGVVSKACVIKIVKIFFLVQEGNLGVIVTPGMHQAFTGFLQQGIPVLFLGDELVDISYGLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN05</accession>
    <name>D6SN05_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AIG2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869194.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3511"/>
    <dbReference type="EnsemblBacteria" id="EFI36066">
        <property type="protein sequence ID" value="EFI36066"/>
        <property type="gene ID" value="Dthio_PD3511"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1984556at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="19547" checksum="2FD9A8825410AF8C" modified="2010-08-10" version="1">MLVFQYGSNMSSKRLNSPERLAGDAQRFGIAHTLHPYRLCFPVWSKTNSCAAASICLASDGRPIFGVLYEIPESLVYRQKASVLNRKSLDAIEGEGVNYDRTEIYVVQSDGAVISATTYIARKPGPERKTSAGYASYILTGLAENDMPPAYREYVAACIVQSNPELAGMVEEWHVTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN25</accession>
    <name>D6SN25_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IstB domain protein ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3533"/>
    <dbReference type="EnsemblBacteria" id="EFI36086">
        <property type="protein sequence ID" value="EFI36086"/>
        <property type="gene ID" value="Dthio_PD3533"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="16"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="117" mass="13666" checksum="757A0324EC1E8092" modified="2010-08-10" version="1">MTNKHQSEVHRLEENLQLLKLTCIKEQYRPAADKAARQNWDHLGYLARLVQAEADARHDRSIQRRIRMARFPGIKTMENFDWTWPTKINRPAIQNLFRLGFMKDKANIIILGGVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN42</accession>
    <name>D6SN42_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1516"/>
    <dbReference type="EnsemblBacteria" id="EFI34168">
        <property type="protein sequence ID" value="EFI34168"/>
        <property type="gene ID" value="Dthio_PD1516"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="99" mass="11635" checksum="5970A1938C00CCB6" modified="2010-08-10" version="1" fragment="single">MSKIKQAHDKIFKNVFSDRKNALNLLGNFLPANILNRLDLKQMVYEKDTFVQKHLKGYYSDLLVTIPLVDSDESVKVYFLFEHKSFSDPDLPLQLLRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN91</accession>
    <name>D6SN91_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1568"/>
    <dbReference type="EnsemblBacteria" id="EFI34217">
        <property type="protein sequence ID" value="EFI34217"/>
        <property type="gene ID" value="Dthio_PD1568"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013445">
        <property type="entry name" value="CDP_4_6_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02622">
        <property type="entry name" value="CDP_4_6_dhtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="12"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="371" mass="41499" checksum="5148AE74F2204B78" modified="2010-08-10" version="1">MFNDIYAGRRVLVTGHTGFKGSWLCLWLEMLGAKTFGFALEPETDLSHFYLSKPEVLCRTADIRSLQEIREAVKYARPDVIFHLAAQPLVRRSYFAPLETLHTNVMGTANLLEACRHIDSVRAIINITSDKCYEDQGNGRGCMENDPMGGSDPYSASKGCAELVIRAYRDSYFPVHTYGANHHTLVASARAGNVIGGGDWGADRLLPDIIRAAAAKKQLKVRNPGHIRPWQHVLDPLCGYLILGKYLLEGRSEYAGAWNFGPAGDTRVTVASIVEMVQNHWDDFSYTFAHETEPLPETATLHLDSSRARKSLNWEPVWDVSDSVQKTVDWYRSFYHNGGILSRKQLQDYCLEAERTGACWVERSGSEGPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN97</accession>
    <name>D6SN97_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869551.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1574"/>
    <dbReference type="EnsemblBacteria" id="EFI34223">
        <property type="protein sequence ID" value="EFI34223"/>
        <property type="gene ID" value="Dthio_PD1574"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HVS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1626243at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="253" mass="30512" checksum="7A4F41058669785E" modified="2010-08-10" version="1">MLIVNNDFVYIHHPKTGGTFVTEMLRNIAFETDDLNILEVPVPKHAGVRTIPPEFQRLPIVINVRNVFEHYVSRYTFRWWAEPNRAKNIFDLDKVEREYPGFPDLSFSDFLRMFNQWHLRLNESKNRAQILTNRELGYNSREFIRLSSYDPMKLLETFDALTDQELKEKFKEFHFLRTENLSQDLYNLLKTYGVRENYLTLFLNAQPILPKKGGRGELKQTWPEYFSPEDIDFVLRRDRLYFRLFPYMQPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SND5</accession>
    <name>D6SND5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAS modulated sigma54 specific transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869589.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1612"/>
    <dbReference type="EnsemblBacteria" id="EFI34261">
        <property type="protein sequence ID" value="EFI34261"/>
        <property type="gene ID" value="Dthio_PD1612"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="450" mass="50476" checksum="837DF5454BA099D0" modified="2010-08-10" version="1">MQSLKPPEKPCNGFNCDILESISDGVFTVDDKWLITSFNRAAEQITGISRNQAMGRPCWEVFHSSLCESECALRYTMESGKPVVGKTCYFVDSRGRRITVSVSTSVLSNDQGEITGGVETFRDLSALESLRLQLKGGFDMGELISHSPAMQKVLELTPAVAETSSTVLIQGETGTGKELVARAIHSLHRGREAPFVAVNCAALPDTLLESELFGYKAGAFTGAEKSKPGRFAQARGGTLFLDEIGDMSLNMQTKLLRVLQDRSFEPLGAVQPEKTDARIIAASNKDLEQLVEMKAFRQDLFYRINVVRIDLPPLRERKEDIPFLVDQFIERFNRLYNREITGVDPQVLSLFMAHDWPGNIRELENVIERAFVLCRSGEIQRSHLPRELIIRERRENAPTDLHTTKQALEAANISRALKQTQNSMTRAARLLGMHRSTLYRKMKQLGLIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNK5</accession>
    <name>D6SNK5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tripartite ATP-independent periplasmic transporter DctQ component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869659.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1682"/>
    <dbReference type="EnsemblBacteria" id="EFI34331">
        <property type="protein sequence ID" value="EFI34331"/>
        <property type="gene ID" value="Dthio_PD1682"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1947990at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="188" mass="21033" checksum="7BF6492DD6FF2208" modified="2010-08-10" version="1">MTGKIINGVDALCSRIDAVVGIIAFCALLTMITAISMQIVFRVYFQALPWSEELSRYMLVWLTFLGATMAYRRGLHITVTFVVGLLPDIVRRLIRTATIAASIFFFAAGMWYALSYIEFQSGQVTASLRLPIPLIYSVMPFSFAVMILYGLHALLLEMFPGHQPGYRGKKAEGQGQDSQPRDGNKQWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNM2</accession>
    <name>D6SNM2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869676.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1699"/>
    <dbReference type="EnsemblBacteria" id="EFI34348">
        <property type="protein sequence ID" value="EFI34348"/>
        <property type="gene ID" value="Dthio_PD1699"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="175"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="390" mass="44148" checksum="EA9474B5D7FEA5A1" modified="2010-08-10" version="1">MIRRDAEATILRLLQGFPAVTITGPRQSGKTTLARAIFSQKPYFSLEDPDMRQLALDDPRGFLSRTAQGAVLDEIQRAPDILSYLQTHMDEHGRMGMFILTGSQHFGLMSDVTQSLAGRTAFVQLLPFSLEEVKRSSASSLELDDLLFAGGYPPLYDRNLTPDIWMPAYITAYLERDVRQILEVQNLEAFQRFLRLCAGRSGQILNLSALATDCGITHNTARSWITVLETSFILFRLYPHHANFRKRLVKSPKIYFYDTGLMCRLLGIQNAQQLAFHPLRGAIFETFVVSELKKACFNFLLNVELYFWRDSNGREIDVIADFGGSLMPIEIKSGQTVNRDFFTNLEHWLKLAGKTAFSPVLIHGGKAEMIRKEIKVTGWQNAARILTTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNU0</accession>
    <name>D6SNU0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869738.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1774"/>
    <dbReference type="EnsemblBacteria" id="EFI34416">
        <property type="protein sequence ID" value="EFI34416"/>
        <property type="gene ID" value="Dthio_PD1774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="88" mass="10268" checksum="62655AA08F1A315E" modified="2010-08-10" version="1">MGGFEFDEGKSKANLEKHGIDFQSAQEFWKDPDLLEIQAKSEGEPRFLLIGRIGAKHWSAVVTYRNDRIRLISVRQSRKKEVELYESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNV9</accession>
    <name>D6SNV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869757.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1794"/>
    <dbReference type="EnsemblBacteria" id="EFI34435">
        <property type="protein sequence ID" value="EFI34435"/>
        <property type="gene ID" value="Dthio_PD1794"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1561024at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="523" mass="56756" checksum="F41F12229A607ECB" modified="2010-08-10" version="1">MIINHSDHGLTALQDRIRENAASPPQRSRESFFDLVMNKNLSTAPPSTVPAVSTPGASGILQGGEQTSSRDENLPPGPRVQKPGPGASQGMEASGTSSGDASTSGSHTMRQKIDFGATHPHMQKSPGPRIETADPAQETTRQVIASVSPAIIKNSVVSSAPKSPAMPEFIDSMLAREKADPLSRDDGAAGHTPPSTQRPAVNSAALEAAGEEKVRVSTLTLEQDQGFSSIKPTVTLAGLESSSNPHDADMKVSRLELKNELPTQKTEATVSSLQPEAGQPGPEQRKAASRAYQEHAAFKSPEINSRTRETESEDHRPGRLAARFESANRSDAIGYDRRGGTCYGIYQLSSNMGTMGEFLDFLEDREPELASRLRQAGPMNTEGRTGSMPEEWQRIDRENPELFSELQHEFIHHNFYLPAARGVESRTGLDMQQASPALREVLWSTAVQHGVHGSMNIFQKVAGEIGYENVESPDREMIEAVYAERSRRFTGSTEAVQSAVQSRFQEEMKQALAMLPGSMETQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP78</accession>
    <name>D6SP78_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1926"/>
    <dbReference type="EnsemblBacteria" id="EFI34554">
        <property type="protein sequence ID" value="EFI34554"/>
        <property type="gene ID" value="Dthio_PD1926"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="846643at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="260" mass="29763" checksum="023169115584945A" modified="2010-08-10" version="1">MNPTDRLRKHLLSLSPLAIALSGGVDSSTLTFFCLENHIEFTAYTFCGDHLTSFEAEHVQKVVTENSIPHLFIPCQPLKDPKIAANSRERCYYCKNDLYFRLKRCVEPGRTIIDGSNASDLSKYRPGQKALKEQGVMTPFASLGFHRMMVEDLAQELGLNIPRFSRSCLLTRFQYGYQLDSDLVQRLGRAEDYLLRAGLSGFRTRVLLDETVLVQVDASEKVGFLNIEPGFQSLMQELFFYPYRVQYMEFSMISGYFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPB8</accession>
    <name>D6SPB8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1966"/>
    <dbReference type="EnsemblBacteria" id="EFI34594">
        <property type="protein sequence ID" value="EFI34594"/>
        <property type="gene ID" value="Dthio_PD1966"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="10948" checksum="EF35BDB27F6C4820" modified="2010-08-10" version="1">MLENFDLLFAVTILLMTLVTYFTRAGGLFVVSRITPTPRVRAFLNHVPASILVAIIVPSLADKGPAEFISAAVTVAAAACTRNLLLSLLAGLLCVSALRAFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPE2</accession>
    <name>D6SPE2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonopyruvate decarboxylase-related protein</fullName>
            <ecNumber evidence="6">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869938.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1990"/>
    <dbReference type="EnsemblBacteria" id="EFI34618">
        <property type="protein sequence ID" value="EFI34618"/>
        <property type="gene ID" value="Dthio_PD1990"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1293048at2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="3"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="436" mass="47138" checksum="2146324EC50CE3CB" modified="2010-08-10" version="1">MSKKFILVLLDGLGDKSFAELDRQTPLQAAHTPFLDHLAARGCNGLYHAGFPGQALPSENAHFAMFGYDPADFPGRGALEALGAGISLDRDQVAVLAHFVCVREEEGKLRLIRDKVEASQEDAGQAFDRVARYSAHGVHIRLVPAKGLFGVLVLTGAVSPFITDSNPILDGRFLSAVMPFEKKAGDEKCINTAAALTSYLSWSYGRLKDAPFNLARENAGKFPLNALVTQRAGRLRDREPFHVRNGIKGVSISSGVVYQGLGCYLGMDVIPGAEKDDPGQEIQARVNAARRHVDQYDFIHVHTKAPDEAAHKKDPLLKKKVIESLDQGLSASLPGLLENDEVILAVTADHSTPSGGPLVHSGEPVPLVITGPGVRVDNVHKFDEISAACGGLGPVRGKEFMYLVLNYLERSRLAGLMDAPVDRPYWPGAGRPFILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPH4</accession>
    <name>D6SPH4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD2022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869970.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2022"/>
    <dbReference type="EnsemblBacteria" id="EFI34650">
        <property type="protein sequence ID" value="EFI34650"/>
        <property type="gene ID" value="Dthio_PD2022"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="117" mass="12344" checksum="A84C043290BDDB84" modified="2010-08-10" version="1">MQTLIVTLHLISCVVLVVLVLLQSGQQGMGVIFGGGGGSLFGSGGAGGILAKLTVAVAIIFFCTSLTFTYMTAKQHETQPSEIVQQHEEESSRDFPLQSMRPDSEDGRETSGPVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPP9</accession>
    <name>D6SPP9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870043.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2098"/>
    <dbReference type="EnsemblBacteria" id="EFI34725">
        <property type="protein sequence ID" value="EFI34725"/>
        <property type="gene ID" value="Dthio_PD2098"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50340VR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1479040at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="196" mass="20904" checksum="01653E918545F363" modified="2010-08-10" version="1">MAALACRIELDKEKGVTVTVENEDGKITQTLVMDGTSIILTCKGQDDTSSITQKQDSIDIKCKNFNLDAESITCQSEKDTVHKSQQKYEIQSTKDMLLKSESNFSAKSDSKAEVSGKSLELSADNKAALSGADVSVKAKNKTDVSGNKLGLSGKMQADMDAMSVKVAAKGKMDVQGKLTTIKGSITNVQGKMVKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPT5</accession>
    <name>D6SPT5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870079.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2137"/>
    <dbReference type="EnsemblBacteria" id="EFI34761">
        <property type="protein sequence ID" value="EFI34761"/>
        <property type="gene ID" value="Dthio_PD2137"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1840881at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="219" mass="24582" checksum="09EC71295094694F" modified="2010-08-10" version="1">MNTYWIIDYRIRLLSDFHAGAGITLVTGNTHGLRLDEESQPYLPATQVRGLLRQAGHNIKRSIPELQGLFKQNFPDGSADIAAEKNYAAVNSPRGWSFTRAMVKDAESREDGLQPWSRQAHVHIDPVSGVVLNLFGYEKAGAKKPGESMELVGRIYSNTPAEEKDAALMLACMRFEDRIGHRRSRGYGKVDWVWDSVRSFTPGSSLEAKTPKDIFEKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPX0</accession>
    <name>D6SPX0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2177"/>
    <dbReference type="EnsemblBacteria" id="EFI34796">
        <property type="protein sequence ID" value="EFI34796"/>
        <property type="gene ID" value="Dthio_PD2177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="158" mass="17982" checksum="8A35F86FCCE4CBA1" modified="2010-08-10" version="1">MDEDDTFNAKLDEETGKFDLSLDSEQGKIEATYPNVGCVEVYPGSRFEYVGSDFDNLALFVPTFGGVYELCIRTLPEENYTSDCSRCGVKDFVNKTAEFNGIYQYEKPSVFEDDIFRNMIDASGNYSMEADNHKFNNTYIFRRSHGDAALEHKAPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPX5</accession>
    <name>D6SPX5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870117.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2182"/>
    <dbReference type="EnsemblBacteria" id="EFI34801">
        <property type="protein sequence ID" value="EFI34801"/>
        <property type="gene ID" value="Dthio_PD2182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="25137" checksum="11F5612D2FCC61F8" modified="2010-08-10" version="1">MKKPTKKSTIPALVLGGMLAYGTIGDKVNSEYQNTTQENAQLETAQTDYKASALENLTNALAPAKAFAQTNQNYQRPDDATLKEWMNQPVEETLAGTNYTKVNDHNYQREVKQSDQPVMVLFYTNAGEASAGLTALTKTLHEKFPEIKLCAYKVTDGSGVHMSKVNEMRNKYPLEKIPSLLFYDTKDFGSGTEYLSQLHGGIKTLDFLKGEIEFYSEAIPKQFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ07</accession>
    <name>D6SQ07_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870147.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2223"/>
    <dbReference type="EnsemblBacteria" id="EFI34833">
        <property type="protein sequence ID" value="EFI34833"/>
        <property type="gene ID" value="Dthio_PD2223"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10979" checksum="F2FB6652BB47B4E7" modified="2010-08-10" version="1">MPQTKIKRESVFQPEFREDLKFWVETDRKTALRIFQLIEAVMRDPFQGMGKPKPLKYLGPGAWSRRITQEHRLVYVVGHERVDFVQARYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ54</accession>
    <name>D6SQ54_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable chemoreceptor glutamine deamidase CheD</fullName>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheD</name>
        <name evidence="4" type="ORF">Dthio_PD2271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870194.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2271"/>
    <dbReference type="EnsemblBacteria" id="EFI34880">
        <property type="protein sequence ID" value="EFI34880"/>
        <property type="gene ID" value="Dthio_PD2271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1863047at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="185" mass="20325" checksum="E93DE8185374F727" modified="2010-08-10" version="1">MRKNVNIHIGEYHASASPSIIHTVLGSCVAACLFDPRSLIGGMNHILLPGKADLNHFDVSARYGVNAMELLINRMMKLGAKRNSLQAKVFGGAHVLPSISRENGVGDKISAFVIEFLQMENIRLINSDIGGSDSRKVFFYTDTGDAYVKKLPSLQLQKIARKEKKASRRVKDIAGKPGDITLFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ66</accession>
    <name>D6SQ66_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870206.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2283"/>
    <dbReference type="EnsemblBacteria" id="EFI34892">
        <property type="protein sequence ID" value="EFI34892"/>
        <property type="gene ID" value="Dthio_PD2283"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="244" mass="27280" checksum="C51989528DAF3BA0" modified="2010-08-10" version="1">MSKPVLILGAGSDIARALAHQLGAAKYDLYLAGRNLEELQKDARDLEIRYAIKARGVYFDALDFASHEDFYDSLETRPYGVVLAFGVLGDESLARSSREQWEKIIHTNYTGCVSILTVAANRLEQAKEGFVAGISSVAGDRGRAANYVYGSAKAGLSIFLSGLRNRLHGSGVRVITVKPGFVRTRMTRDLELPPRLTATPEQAARDIFQAITKKRDIIYTLWIWRWIMLVIKSIPEKIFKRMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ94</accession>
    <name>D6SQ94_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870234.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2311"/>
    <dbReference type="EnsemblBacteria" id="EFI34920">
        <property type="protein sequence ID" value="EFI34920"/>
        <property type="gene ID" value="Dthio_PD2311"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2062650at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10743" checksum="B7D01E0B993E5716" modified="2010-08-10" version="1">MELKLPSSRDLRSIWQESFLGQKGFFIPGERKLPIGREMKIDLVVEGSSWGSLKMVPVWANLSGPESSDLPRGTFLLLTSCEQELEKRIKSCCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQC1</accession>
    <name>D6SQC1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870261.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2339"/>
    <dbReference type="EnsemblBacteria" id="EFI34947">
        <property type="protein sequence ID" value="EFI34947"/>
        <property type="gene ID" value="Dthio_PD2339"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="280225at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin_N" evidence="2">
        <location>
            <begin position="42"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="452" mass="51413" checksum="312F9D982DBF376C" modified="2010-08-10" version="1">MDDKAFQQEIQDRVRKTIAPVFSKYGMDVNWLDSTMKWKPLILVIGSYSSGKSTLINELLEIDVQRTGQAPTDDSFTVITNDGENVPGETPGSTLVNDPRYPFAGLKAYGENLISHLCLKNVPSPLLENTAIIDTPGMIDSTAERDRGYKYLEVIGELAAMADMIVLMFDPHKAGTIKENFSTIRNILPGRTGEDRVVYVMSRIDECDNLSDLIRSYGTLCWNISQMTGRKDMPHVFLTYSPREARLDQSNQEWPQERQELKEKIGSAQAMRINHILENIDRKTGELELVCEALHRFSRRVRQLLSGTFKWTLAAALAVFALGFVLLQGHQPLQDQGLFSGITQTSLLSMEVIVPAAAALLTFVLGWVIFARVRFRNLLQKTLRNPDNLVHLDSDYRRSLWAKVKSHVLDQLRQRTVRQHLFQSGASLDRVRKFIRRDLKEYYSKIGRPRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQD6</accession>
    <name>D6SQD6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870276.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2354"/>
    <dbReference type="EnsemblBacteria" id="EFI34962">
        <property type="protein sequence ID" value="EFI34962"/>
        <property type="gene ID" value="Dthio_PD2354"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1262717at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="27589" checksum="C017CF4E91109C78" modified="2010-08-10" version="1">MSLIALLTDFGIEDPYVGQMKGVVYSRCPGADIVDLTHGVQAFNIHQGGFLLACSLDFFPPGTVFIAVIDPGVGSDRGIVLAETRTCWILAPDNGLLSQALDAGLLKTCRRFLGNPPSSTTFHGRDIFAPLGADLAEKQKVPADFEAFDPQELVRLYLPEPAACSTGVKCVVLHRDHYGNLVLNLDIDPWAGRLQGARMRIGGYEMVLVAYYAAIPEGCLGLVTGSQGKLEIAAREYSAARLLGLAPGDEALFSFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQE4</accession>
    <name>D6SQE4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870284.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2362"/>
    <dbReference type="EnsemblBacteria" id="EFI34970">
        <property type="protein sequence ID" value="EFI34970"/>
        <property type="gene ID" value="Dthio_PD2362"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="383" mass="41292" checksum="040259D918626E09" modified="2010-08-10" version="1">MSENRITKFAIPEIIFGHGSLRYVAQCAMRLGAKRALLVTDEGLIHSGWAGHVQEILKDDNLDYIPFDQVDSNPRDYQVHEGAKIYDREKADVIISLGGGSPMDTAKGIGTIVGNGGRIGDYEGANKIMRPLPPMIFIPSNAGSGSDISQFCIITDVERQVKMSIISRSLVPNVSIIDPDLLMTKSDEMVVASAVDALAHAIESYVSPLASPFTENQAMKAIELIAAYLQPALESRSCEAMEQLSIASTAAGMSFSNAGLGIGHALAHSLGGIFDTLHGLVHPIVLPSVMRYNLPACPEKMCIIGRIVQGSCTTCSSDQGQEGISRLEELFAGLGIPVHLRDIVPDASRLEQICKMAVHDACMLTNPRKAGWEDLFSICQEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQH0</accession>
    <name>D6SQH0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2388"/>
    <dbReference type="EnsemblBacteria" id="EFI34996">
        <property type="protein sequence ID" value="EFI34996"/>
        <property type="gene ID" value="Dthio_PD2388"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="233" mass="27058" checksum="4B2F9D95218C94FF" modified="2010-08-10" version="1">MQETLPRHIAIIMDGNGRWAGRHGLPRVEGHKQGTRSARAIVEESRRLGIQHLTLYAFSRENWSRPRDEVDFLFNLLGEFLNGELPTLMRQDIRLNILGETGELPLATRKILQMACNRTRSNQSMQLNLALNYSGRLEIQRACRLMQEKGLDACQMDPREFGQYLYTAGQPDPDLVIRTSGEYRISNFLLYQSAYSEFYFTETLWPDFDSGELHKALEDYRRRNRRFGGVEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQN4</accession>
    <name>D6SQN4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ORF">Dthio_PD2454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870374.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2454"/>
    <dbReference type="EnsemblBacteria" id="EFI35060">
        <property type="protein sequence ID" value="EFI35060"/>
        <property type="gene ID" value="Dthio_PD2454"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="199"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="227"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="516" mass="57563" checksum="F0E4E85CFD32DAB8" modified="2010-08-10" version="1">MQVQNKVIILDFGSQYTQLIARRIRESGIYSEIHPCTVSLEDLKAMQPSALVLSGGPSSVAGEESPQVDQGVFQLGLPILGICYGMQLMAHLFGGQVEPARNREYGRASFEFVSDCPLWEGLGDKDGLTVWMSHGDTVLTPPPGFEVLGRTSSVEIAAVGDSQQKIYGLQFHPEVAHTEEGYRILHNFLFKVAGLVPDWSMTSFIQDCIQEIREMIPDDEQVVCGLSGGIDSTVVAVLLHKAIGKRLHCILVDNGVLRHNEALEVVESLTKHFDLNLKHVEAQDLFLSRLHGVKDPEEKRKIIGHTFIEVFEKEAKSIPDVKWLAQGTLYPDVIESVSFKGPSAVIKSHHNVGGLPEKMDLKLVEPLRELFKDEVRKVAVELGIPDTIVWRHPFPGPGLAIRVIGTITPERLEILRKSDRIVQNELFASNWYTRVWQGFAVLLPLKTVGVMGDERTYEHVVALRIVDSIDAMTADWSRIPPEILARISNRIINEVQGVNRVVFDISSKPPSTIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQV9</accession>
    <name>D6SQV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870449.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2530"/>
    <dbReference type="EnsemblBacteria" id="EFI35135">
        <property type="protein sequence ID" value="EFI35135"/>
        <property type="gene ID" value="Dthio_PD2530"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="940042at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="29816" checksum="11C0DFD34297068A" modified="2010-08-10" version="1">MLEELKSVQEQARVMAGKYSLGFYTRYSREHARSKEIFFSHPLIQRLREDVVPFLNDGFGHGIEHCKKVSIDAGTLALIETRSWLDVKAGKRITLLAQMAGLLHDISRHERDHARKGAEFSRIILQYYPLGPEELDGLAFAVRNHEAFREVLEPADQRQAVLSDVLYDADKFRWGPDNFVTTLWEICSCEEWSLEDIIDRFPKGLSYIEKVQETFRTSTGRLYGPEFIQCGLEMGRALYRNLRDQYSDSLEHNLLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQX1</accession>
    <name>D6SQX1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2542"/>
    <dbReference type="EnsemblBacteria" id="EFI35147">
        <property type="protein sequence ID" value="EFI35147"/>
        <property type="gene ID" value="Dthio_PD2542"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="143"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="322" mass="38079" checksum="655EDC37AB21D489" modified="2010-08-10" version="1">MRNFVFFERIIWLHVRIRADEYPSAGDLAREFELSERTAQRTIANFRDRLGAPIEYDRARKGYYYTDKDYEFSPARVSQEEILAVVLARSLLDKSTGGYVSRIIKKFSRRLMNMTSLLGFGQDMMDKAFSAVWNQYSPAQAQVFDIVSQSLLNCRILAFDYTSPATAEPTTRKAEPHHLQHYMGSWVLIAFCLEKYDWRKFYLSRMARVTQTQDWFQPRPESEWSYQVESSFGIFQDRTSRPVVLRFSPFRARWIREQVWHPDQKMRELEDGSLELEIPVADFREIKLKILSFGADVEVIRPESLRREVAAEIQKMKKIYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQX8</accession>
    <name>D6SQX8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2550"/>
    <dbReference type="EnsemblBacteria" id="EFI35154">
        <property type="protein sequence ID" value="EFI35154"/>
        <property type="gene ID" value="Dthio_PD2550"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1256698at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026354">
        <property type="entry name" value="4helix_suffix_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04258">
        <property type="entry name" value="4helix_suffix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="189" mass="21567" checksum="B58485A38C0A2817" modified="2010-08-10" version="1">MTSKQEPPQLIPAHGGYQDLKSYQMAELVYDGTVKFCQRLVNPRSRTHDQMVQAARSGKQNIVEGSMASGTSKKTELKLVGIARASLEELLQDFQDFLRLKGYSLWGKDHPLSKTVRGLCYKKDRSYATYRTYIENAPPEVAANTMICLIHQTNYLLDQQLRALEKEFLEGGGFTERLYRTRSQARRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQY6</accession>
    <name>D6SQY6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35162">
        <property type="protein sequence ID" value="EFI35162"/>
        <property type="gene ID" value="Dthio_PD2560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="56" mass="6868" checksum="875B5B38C4BA6C96" modified="2010-08-10" version="1">MKELKIEQAGEFWAVYRYSKSKGEWIILGEWPEKDHALQDMETWRKYLERCSTDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR05</accession>
    <name>D6SR05_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870495.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2580"/>
    <dbReference type="EnsemblBacteria" id="EFI35181">
        <property type="protein sequence ID" value="EFI35181"/>
        <property type="gene ID" value="Dthio_PD2580"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="453" mass="52750" checksum="AC88F0179CCBE3FD" modified="2010-08-10" version="1">MDLKEIFKQLILDAQQAEQPRILPRTCCFPLVRGKVIALTGPRRSGKTFLFQAMIQDLLKQGIESTDIISVNLEDNRLFGLETPGLESLLQAYFEMWPEKKDRDTYLFLDEVQAVPGWDRFVRRVLDSERMYVFVTGSSSSMLDRELSTVLRGRTLSFRVMPLSLPEYGLFHGSDLSDAFSSRAVAAWGNRQEQYMRYGGFPEIVSMPESLKRRTLRDYLDLMLYRDIVERFDVKNTTLFRHVLNMLLYNMSGLVSVNRLFNTLKSQGHALSRDTLYDYFSYLEEAMLFYFVPVRSASVRKRQINPRKVYVLDQGFFWMASTGLTRDQGRILENMVFIELVRRENKVMYIKGRQETDFLAVSPEGRKQLIQVCLNMYDKTTRKREMDALSQAMDEEGLDRGLVITASELGEECKSNKRVDILPFWKWALSRDDNQDEHGYTAGRLPESRLFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR61</accession>
    <name>D6SR61_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870535.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0500"/>
    <dbReference type="EnsemblBacteria" id="EFI33177">
        <property type="protein sequence ID" value="EFI33177"/>
        <property type="gene ID" value="Dthio_PD0500"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120305" checksum="A8CC1D9602B5B9DA" modified="2010-08-10" version="1">MSKGRELTAMLNEQLELGMDPLVKDFMGSRFDSAFFEEDEDVDPLGAQLYLTSWDDNVDFLDIQNLQNDPDFSGYFKSEAEFDVVYTVTAADDGSSLDADSVREEPANSVQFDFEPFPNDGATVRIDNFGSEDQLKTNVDIDDDKYVWDTPESDQIQIGFDWEEVPDSYLVYLRGVDEDLVDEVSSAIEAEDSTQKIINLIGQHEDFSTDWLKHELDQAGLSIQSIDVTPEEPELGQRFTVDVTLEELVGVETENLTVNLAIAGTEIDETIEVDSLQGAQASVTFEELVIDEAGEYAIEVTADADNADAVTSSSVIEITPEIRDDFALTAEQYDLTDTDLENLVNQEFEQEVAIADWYDIVDSYEEEGIALFDSLGMDPDGIRSAGVLRDGEQFYGTGESRAYFVRLGEVSGSFMVHDSTEVDGLPLNLGSWDVTNHVLVELDVDDPPAQISVDNIEIDPSSPSVGEDFTIDATVSEIAGVETEDLAVLLTIHDEDGRGVLGKYKYPGEIRGESIDVEFDTLDDGSSISLDDPGEYEVVVSAQAENADPDFDYDSTFFTVYEEGYSQLLIDYVEVNPSSSSVGEELTVNFGVSEIAGVETEDLEVILNIYDENGNMMGSNFTRPGELQDESIDVEFDTFIDGSSISLDDPGEYEVVVSAQAENADPDYDYDSTYFTVRSDSIPDTITVEKHELYEAASDGSFTVERHNTEYTFWKSDKNIDTSNITNMSELFAGTDFDEDIGHWDVSNVTDMSYMFYNAYNFNNGGSGSIDEWNVSKVTDMSGMFQNSNLRQDIGSWDVSSVEYMNWMFHDAEHFGHSMFNDTIGDWDVSNVQGMSGMFWGANVFDQDIGNWDVSNVEYMYAMFYQTIFDQDISDWDVSNVENMVWMFGHSDFYQDISGWSVPEISEEPQYFAYGSPLEGKEEWHPQWGGNPYLDDLVFTETTGSENSEHQIYEASELGMTFSYQEKLPLEEDLDLDAFVIQISDVEGNLENIGIDSADVDGAHLTLNFSDELNLEWNGEQYVMFSEDWELTAESLDDFGVAVDYEDGNISDQEDFNKKVDLQGIAQEFEELCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR84</accession>
    <name>D6SR84_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870558.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0526"/>
    <dbReference type="MEROPS" id="M23.009"/>
    <dbReference type="EnsemblBacteria" id="EFI33200">
        <property type="protein sequence ID" value="EFI33200"/>
        <property type="gene ID" value="Dthio_PD0526"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019301">
        <property type="entry name" value="Flagellar_prot_FlgJ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10135">
        <property type="entry name" value="Rod-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rod-binding" evidence="3">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="248"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="359" mass="39791" checksum="ABA1B6DC816A8546" modified="2010-08-10" version="1">MSSAISNQGMDQLHQGRSSSRDAEVKSLQDRFGSGKGDKEELRKASQEFEAIFIQRMWEQMRETVPQDGYLHSDEKEMYMSMFDEKVSVEMAKSGGIGLADMIFDQLSGQVEKSNMDASSDTLPSMGQEPQGQNFPTLEEEDNPRDDTEHNLRVQRILDMNIPSDRKAEMLAGQIEAAFGGKKPEVPELKPASEPPDSLESLEAAQPVEKDGEDDPQSLPPLQYPVQGQVSSDFGWREDPFTGEQAWHAGIDFAVEEGTPVKAGWPGEVVFADKDGGYGNKVILEHPNGWKTVYAHNSKNLVQEGDRVDQGQEIARSGNTGRSTGPHLHFEVRQGDMAWDPNLIKDRMLAGLDIGHTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRB7</accession>
    <name>D6SRB7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ORF">Dthio_PD0559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870591.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0559"/>
    <dbReference type="EnsemblBacteria" id="EFI33233">
        <property type="protein sequence ID" value="EFI33233"/>
        <property type="gene ID" value="Dthio_PD0559"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="493793at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="45364" checksum="1C95B9BF7E03C3C7" modified="2010-08-10" version="1">MSISQDLFNTARELIPGGVNSPVRAGSVGMHPLFIARAQGAYMYSQEGDPYIDYVMSWGPMILGHNHPRVRKALEDALQNGTSFGAPCKPEIDLAQEIIDALPGVEMVRMVNSGTEATMSALRLARGYTGRSRVIKFTGCFHGHVDAFLASAGSGAVSIPGTPGVPDEVVAQTLLADYNNLEQVQELFTRYGSDIAAIFVEPAAGNMGLVPPQPGFLEGLRRLADEYGALLVFDEVITGFRLSYSGAQGYYNVIPDLTCLGKIIGGGLPVGAYGGKREIMNKIAPAGEVYQAGTLAGNPLAMTAGLTTLQALKEHDYNYLEEKTSELAQKLKEVLAEKGLPVQLNLLGSLFTLFFTPDPVTDLTSAKKSDQELFRKFYTGMREQGIYLAPLNYECAFNSFAHGPKEWEKTLESAKNLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRH4</accession>
    <name>D6SRH4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook-length control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870648.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0616"/>
    <dbReference type="EnsemblBacteria" id="EFI33290">
        <property type="protein sequence ID" value="EFI33290"/>
        <property type="gene ID" value="Dthio_PD0616"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1131105at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="2">
        <location>
            <begin position="582"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="718" mass="80409" checksum="7827495EB867C9A3" modified="2010-08-10" version="1">MQNFPLMDISQSSGDLLPGMNSSRFGGGEFNDGFRDVFQDALQSPQNNKSPLPSDYNPLPDAGEGRHEQELSREEFAGVKDFLRQQGVSEQEIKNLEESFNESGLTWSELGDELGLDQEMTEMLMQAVKNASREGDSRKYESAGLRLDQKISEEDMDAVKTMLREQGISEQKIQKLKDSFQESGLTWSELGDELGLDREMTEMLMQSVKQEGWGSEDLMSGEMDDMWDEKITPEELDAIKEMLLEQGIDSSELQKLQEKVDNSELSWRELVSRLDMADSHPPMELSSGQRQDLVSFLSELGFNAQERKDLIRDVEQGRLDRVAEQLASRLDKMEDGQRVSLSRSQLESLLQGFRAQSRDRSEYSAFADKELGRSDLKNLLGMIRQDSRESRADGLLQGLKNAAGDSGSRLSREENSLLRMIEAAKEEGKGRSAERGNASANPEAEKKLKDTREKSERSQSMHSGRENSERSEGSKSSRENQDSRNERSGYSAVKDSQELRDQALSGEASRDGGRDSGSNNQDPWEKFLSRVRSDTSQEVRTAAAAAGAREASEAARQGGQAAQREQISQQVMEQVRSGTFKDMGQGKSKMTLQLNPPNLGMLSVVLKMQGSEVRAMVSTSNHEVAQVINDNLPQLRSSLEQQGLRVGKIDVHTQQPDNQPGSWQGREEHNKARDRMKKAMEKARLREMEQEGKGLFKPQKQETVFGKNMSSTGLSIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRT2</accession>
    <name>D6SRT2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870755.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33398">
        <property type="protein sequence ID" value="EFI33398"/>
        <property type="gene ID" value="Dthio_PD0729"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZV8Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2084394at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="118" mass="13726" checksum="C758F8DDF63C188F" modified="2010-08-10" version="1">MIRQIYDSRFKELENVLLDEGLCMKYYGYIMKGDHMQRTTIMLPRELKIRAYSKSRKMGVSLGQLIREALQKEIDSTEAGNGLQDCFYADKAVYQGDSPPDFSAEHDEYLYGESHDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRU6</accession>
    <name>D6SRU6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870765.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0744"/>
    <dbReference type="EnsemblBacteria" id="EFI33412">
        <property type="protein sequence ID" value="EFI33412"/>
        <property type="gene ID" value="Dthio_PD0744"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2169960at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="107" mass="11688" checksum="64B4F4A1AD1380B6" modified="2010-08-10" version="1">MCFAAWLLSGSAPAENSLLVFYQALTVVFFIFGAAIAVIGVVVTIRPSALKPLEKKSNRFISKEDIINLLKRLRQGYLNLTARHPRVFGLLAALGGLLLIFLALQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRV3</accession>
    <name>D6SRV3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arm-DNA-bind_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0752"/>
    <dbReference type="EnsemblBacteria" id="EFI33419">
        <property type="protein sequence ID" value="EFI33419"/>
        <property type="gene ID" value="Dthio_PD0752"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arm-DNA-bind_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="10914" checksum="5F5E869EC363A268" modified="2010-08-10" version="1">MPRQNLTPKFVTNPPKPTDKPKTDYFDTQVSGFILEVRSSGKATYYLRYRDVAGQLKQVKLGTPETLSLDGARSRVSLAPKNSPCLPEDYALFSLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRW0</accession>
    <name>D6SRW0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870778.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0760"/>
    <dbReference type="EnsemblBacteria" id="EFI33426">
        <property type="protein sequence ID" value="EFI33426"/>
        <property type="gene ID" value="Dthio_PD0760"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="147" mass="16482" checksum="F49526C9C5B735D2" modified="2010-08-10" version="1">MKRCFIDSNIVVYANDTRAKSRQSRAIETISACMRAGNGFISIQVLQEYANIALKKLNQDTPVVMRQLRLLEILRMVTPAPRLVRRAVELSKSYQISFWDAGIIAAAESADCEVIFSEDLSIAQYYAGIVVLNPLEDGFDLSEYISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRY7</accession>
    <name>D6SRY7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870805.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0787"/>
    <dbReference type="EnsemblBacteria" id="EFI33453">
        <property type="protein sequence ID" value="EFI33453"/>
        <property type="gene ID" value="Dthio_PD0787"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50346E9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1864857at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005598">
        <property type="entry name" value="ATP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03899">
        <property type="entry name" value="ATP-synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="15383" checksum="FAA0B1DBB9E63522" modified="2010-08-10" version="1">MNTLVENFLYKRGFVLPKVRFLVRNQFYLSILGLFVFIIFFPVPWIVGFGIGALLGSLNFYFMARLAQELVHIAKGAATPLLFSFYVRLILTGLVLYVAIVYWNANIFALLLGLSVILLNVLIFGITLVGQKFKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS47</accession>
    <name>D6SS47_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase IS66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0022</name>
        <name evidence="4" type="ORF">Dthio_PD0847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870863.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0022"/>
    <dbReference type="EnsemblBacteria" id="EFI32736">
        <property type="protein sequence ID" value="EFI32736"/>
        <property type="gene ID" value="Dthio_PD0022"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33513">
        <property type="protein sequence ID" value="EFI33513"/>
        <property type="gene ID" value="Dthio_PD0847"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1272226at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="193"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="530" mass="60325" checksum="30DC1EF7B6455D8F" modified="2010-08-10" version="1">MKKKVQSIDLDQEQIDALLQRASKNELEETDLDIIKALVQAIQLLHQAVDDKAASIKRLLRTIFGASSETKKKLFQEDDQQNKDQKSSQDPVQKPPDEKPPKGHGRNGKDDYTGAAKCIYPHQTLKPGDICPLCGQGKVYPIKPKFRIRITATAPLTAKIHELKSLRCNCCLEVFTADPPEDIGEKKYDEPARSMIAILKYGSGFPFHRLEKLQESLGIPLPAATQWDLVEQTGTQLLPVYDELIRQAAQGEVVHNDDTNMKIQQLIKENKEAGPKRKGMFTTGIVSVLQGRHIALFATGRQHAGENLEEILKKRDHNLPPPIHMCDALARNIPKGLQIILANCLTHGRRNFVDILDNFPDECRYVIEQLAIVYKNDDMAKKQEMSAQERLVWHQQESAPVMSELKSWAWAQLEEKKVEPNSGLGKALAYMQKHWDPLTLFLREPGAPLDNNICERALKKAIQHRKNSLFYRTLRGARIGDLFMSFIHTCQLNKVNSFDYLTQLQKNIEEALAAPQKWMPWNYRENLPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSA7</accession>
    <name>D6SSA7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0907"/>
    <dbReference type="EnsemblBacteria" id="EFI33573">
        <property type="protein sequence ID" value="EFI33573"/>
        <property type="gene ID" value="Dthio_PD0907"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50332K1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1852084at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="12283" checksum="BFFF246F86CFEBA6" modified="2010-08-10" version="1">MSRQDHEPVKLDLNNPVFQRHLFRLQKNEQLAVLGTLRKISKMSWQQVYQDRGLNWEVISSRSGPHGARLYTFRIGQGFRGVAFHEQTWLRILSLHPDHDTAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSD0</accession>
    <name>D6SSD0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpA</name>
        <name evidence="17" type="ORF">Dthio_PD0931</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870946.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0931"/>
    <dbReference type="EnsemblBacteria" id="EFI33596">
        <property type="protein sequence ID" value="EFI33596"/>
        <property type="gene ID" value="Dthio_PD0931"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="16">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="14">
        <location>
            <begin position="149"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="15">
        <location>
            <begin position="371"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="13">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI33596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="502" mass="54834" checksum="D5410E2619747FB4" modified="2010-08-10" version="1">MQIKAEEISQIIEGQIKNYEKRVEMSETGVVLSVGDGIARVYGVENAMAMELLEFPGGVMGMVLNLEEDSVGCALLGEDTHIKEGDMVKRTGRIVQVPVGDAVQGRVIDPLGNPLDGLGPIEAKEHRLVEVKAPGIVPRKSVHEPMNTGLKAIDAMTPIGRGQRELIIGDRQVGKTAICIDSILAQRETDVHCIYVAIGQKKSTVAQVVDTLRKYGALDFTTVISATASDPASMQFIAAYAGCTMGEYFRDKGQHALIMYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKMSDEHGAGSLTALPIIETQAGDVSAYIPTNVISITDGQVYLEPSLFYAGVRPAINVGLSVSRVGGAAQIKAVKKVAGTLRLDLAQYRELAAFAQFGSDLDKATQKRLTRGERLVELLKQPQYQPMSSEEQVISLFSGTKGYLDDLAVEDVSKFESEVLEYFRSQKPEILKEIKDTGDLSSDLENRITAAMDEFKKTFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSF8</accession>
    <name>D6SSF8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTS system sorbose subfamily IIB component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870974.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0959"/>
    <dbReference type="EnsemblBacteria" id="EFI33624">
        <property type="protein sequence ID" value="EFI33624"/>
        <property type="gene ID" value="Dthio_PD0959"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696140at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.35.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004720">
        <property type="entry name" value="PTS_IIB_sorbose-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036667">
        <property type="entry name" value="PTS_IIB_sorbose-sp_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03830">
        <property type="entry name" value="PTSIIB_sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52728">
        <property type="entry name" value="SSF52728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51101">
        <property type="entry name" value="PTS_EIIB_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-4" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="154" mass="17602" checksum="46ADC80DE5E75118" modified="2010-08-10" version="1">MFWVRIDNRLIHGQVIETWLPYAGSSTILVVNDELAADPVRQEIMGLAVPSHIDITFASIQESPRVLHTTLKDRLSSVFILFDNCPDARQAFDQGLNFDWINIGNIHYSPGRKQVCAHIALSQDDSLCLEYFYRQGVKLDFRCVPHKSVQVDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSK4</accession>
    <name>D6SSK4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysulphide reductase NrfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871019.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1006"/>
    <dbReference type="EnsemblBacteria" id="EFI33670">
        <property type="protein sequence ID" value="EFI33670"/>
        <property type="gene ID" value="Dthio_PD1006"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="42648" checksum="3351982099FE2ED4" modified="2010-08-10" version="1">MLEKAIKGSALYWIWLLVLLAVIGVGFGAYLQQLDQGLSVTALNRDISWGLYIAQLTFLVGVAASAVMMVIPMYLHNHKAFARMLILGEFMAVATIIMCLLFVVVDLGQPQRLWNVVLYPTPSSVLFWDMVVLNGYLFLNILIGWVTLQAERKRVGPPRWIKPFIYLSIPWAISIHTVTAFLYAGLPGRDFWLTASMAPSFLASAFAAGPALLILLAFAVKIFAKWDPGREAIQSLAKIVTYALAAYLFLIGCKIFTAAYSMVPDKLAHWEYLYFGLEGHTMLSVFMWVSTAAGVSALLILLFPKNRQAENILAFACVLVLISTWIEKGMGLITAGFVPTPMKEVLTYAPTGPEILITLGIYGIGFLIITVLWKVGIGVRKEIEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSN7</accession>
    <name>D6SSN7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871052.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1042"/>
    <dbReference type="EnsemblBacteria" id="EFI33703">
        <property type="protein sequence ID" value="EFI33703"/>
        <property type="gene ID" value="Dthio_PD1042"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="99" mass="10706" checksum="0BBD014EAB127E27" modified="2010-08-10" version="1">MQDFRYLEDVLTLEYDPGLCMGCGSCVQVCPHRVFDVGEQKAVLLDPGGCMECGACALNCPAGAIKVRPGVGCAQAILNSWLAGMPVLRRFFRRDSCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSU6</accession>
    <name>D6SSU6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="1">IOR</shortName>
            <ecNumber evidence="1">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871111.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1101"/>
    <dbReference type="EnsemblBacteria" id="EFI33762">
        <property type="protein sequence ID" value="EFI33762"/>
        <property type="gene ID" value="Dthio_PD1101"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342322at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03336">
        <property type="entry name" value="IOR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="POR_N" evidence="2">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="394"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="610" mass="66542" checksum="BE481659242EEB5B" modified="2010-08-10" version="1">MNLLDPKSGARELLLGNEAIVRGALEAGVGFISCYPGTPSSEVPDTFFRLSDRGDYYFEYSINEKVAMEVAGGAALGGVPTLVTMKHVGVNVAADPLMTLAYIGTPGGLVILCADDPGCHSSQNEQDNRYYVRLAGLPCFEPATAQECKDMTREAFELSVRWQQPIMLRTTTRINHMRGPVTFGELPPAKISGEFVKNPQRFVSVPAVGRARHKALLTNLEKIRPEINSSPWNRVYGQGNDGVIVSGVSRAYLSDVLKLYPDLKVKVLELGLGYPFPQDLVADFVQSVDRVLVLEELEPILENEVRLVCQKRGLSTHVQGKDQDLPLFDEYSTSGVTAALHRFLGRDVPDQQICSIEQEKLPARPPNLCAGCSHRSVYVRVRKIFGDDAVYSSDIGCYTLGMLPPLKAADFLLCMGSSVSSGCGMSRAVKNPVVAFIGDSTFFHSGITGLANAVYNQHDLLLVILDNRTTAMTGHQPHPGVDQSLYNKKPGHLDIEPLVKACGVEQVKKVKALNQKALDQALNEMKDAPGVRVLIAEEPCPLYARRVLGQKRTQKAKVAVSDESSLECLHTLACPAFYLEGEEVRISPVHCAGCMVCVQLSSSIKPESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSV5</accession>
    <name>D6SSV5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1110"/>
    <dbReference type="EnsemblBacteria" id="EFI33771">
        <property type="protein sequence ID" value="EFI33771"/>
        <property type="gene ID" value="Dthio_PD1110"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="22126" checksum="1158C07A18F60A4C" modified="2010-08-10" version="1">METSDDEIKAPKIRIREMGIDDLAPVYHIGEEVFTAEFSTSLYRTWDEYEIINLYSSDNELCLVAELDDHIVGFALATTVEKPRSAWKYGYLTWLGVRKNLQHAGVGNRLFKEVVRRMEQMGVRMVIVDTAGDNVSAIRFFQKQGFDDMKEHVFLSMNLSRKSKAKGGKKKRPKSGRKSIVQKKKTPKRTGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSW7</accession>
    <name>D6SSW7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-1,6-bisphosphate aldolase, class II</fullName>
            <ecNumber evidence="4">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871132.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1122"/>
    <dbReference type="EnsemblBacteria" id="EFI33783">
        <property type="protein sequence ID" value="EFI33783"/>
        <property type="gene ID" value="Dthio_PD1122"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="307" mass="33722" checksum="D3F472CFB3D2E087" modified="2010-08-10" version="1">MPLTSPKEMFDKAYQDGYAIGAFNVNNMEIIQGIMKAGEAEQSPLILQVSAGARKYAGQNYIMKLMEAALKESDLPVVLHLDHGQNFEICRDVISDGFTSVMIDGSHLPFEENIALTKQVVECAHGQGVWVEAELGRLAGVEDEVSSAENVFTDPDEAVEFVERTGCDSLAIAIGTSHGAYKFKGEPTLDFDRLEQISSRLPGYPLVLHGASSVLPEFIDMANRYGGQVSDAKGVPEDFLRRAAKSGVCKINIDTDIRLAMTAVIRKFFHEKPQEFDPRKYLGPAREAVQEMVQHKIKNVLGSSGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSX4</accession>
    <name>D6SSX4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purN</name>
        <name evidence="4" type="ORF">Dthio_PD1129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871139.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1129"/>
    <dbReference type="EnsemblBacteria" id="EFI33790">
        <property type="protein sequence ID" value="EFI33790"/>
        <property type="gene ID" value="Dthio_PD1129"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1815747at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="226" mass="24336" checksum="D3BE557962E803F3" modified="2010-08-10" version="1">MPYKIAVLISGSGSNLQAIIDRIEQNVLDARITRVISNKPGVSGLERAERHGLSTTVIEHKDYPSREDFDAALVRVIQDSGADGVILAGFMRIITPVLINAFPGNILNIHPSIQPAFPGVHAQKQAAEYAVKLSGCSIHFVDEKMDHGPIIIQAAVPALAGDDEKSLGSRILALEHRIFPQAVQWLAQNRLEINGRTVNVLNAPSPAVVEADTYPALVSPGLEDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSZ6</accession>
    <name>D6SSZ6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">carB</name>
        <name evidence="17" type="ORF">Dthio_PD1151</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871161.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1151"/>
    <dbReference type="EnsemblBacteria" id="EFI33812">
        <property type="protein sequence ID" value="EFI33812"/>
        <property type="gene ID" value="Dthio_PD1151"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48855at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="683"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="941"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="941"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="845"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="847"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI33812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119176" checksum="C747C772CAE34E41" modified="2010-08-10" version="1">MPKRTDIKKIMLIGSGPIIIGQACEFDYSGTQALKALKEEGYQVVLVNSNPATIMTDPDLADQTYIEPIEPDTVARIIAREKPDALLPTLGGQTGLNTAVALSENGVLEKYGVELIGASLPVIQKAESREQFRRAMENIGLKVPKSGIARNMDEARQWTSTIAFPIIIRPAYTLGGTGGGIAYNLEDLEEKAAYGLSCSMTHEIMLEESVLGWKEFELEVMRDKNDNCVIICSIENLDPMGVHTGDSITVAPSQTLTDREYQVMRNASLDIMREIGVETGGSNVQFAVNPDDGDLVVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDEIPNDITRETMASFEPTIDYCVVKIPRFTFEKFPGSQDMLGTSMKSVGETMAIGRTCKEALQKGLRSLETGHIGLTTDLPSGEPDLEGIRSRLRFPHSLRLFALYEAFMADMDIQELYDLTSIDPWFLRQIQELVQMEKKLRNFSLEQSLSLDNPYLKPVLTEAKTLGFGDRHLARLWKKDEIFVRTLRCELGIEPTYYLVDTCAGEFEAYTPYFYSTYEKGREVFPKNTRKIMILGGGPNRIGQGIEFDYCCVHAAYSLKEMGLGSIMVNSNPETVSTDYDTSDFLYFEPLTFEDVMNIIEFEKPEGVIVQFGGQTPLNLAVPLLQAGVPIIGTSPDSIDRAEDRERFQALIAKLGLMQPANGTARSIEEARIIAADIGYPVVVRPSYVLGGRAMEIVYDEEHLITYFKNHVVVAPEHPILLDKFLEGAIEVDVDALSDGQDTYVAGIMEHIEEAGVHSGDSACVIPPHTIEQDLLREIEAETISLARELSVVGLINIQFAIKEGRVYILEVNPRASRTVPFVSKATSVPLAKLATRVMLGEKLKDLDPWSMRKQGYYSVKEAVLPFGRYPGVDVLLGPEMRSTGEVMGIDKGMGLAFMKGQMGAGQMLPEKGCVCISVTERDKKDCMEPARIFHEMGFSIKATRGTAAFLQDNGIPAQVVNKVYEGRPNIIDHIKNKEIDLLINTSSGKKTKHDSSSLRQAAVLYRIPYTTTMAAARAMASAIKERAGEGLQVQSMQEYYRNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST34</accession>
    <name>D6ST34_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sel1 domain protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1189"/>
    <dbReference type="EnsemblBacteria" id="EFI33850">
        <property type="protein sequence ID" value="EFI33850"/>
        <property type="gene ID" value="Dthio_PD1189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088068" evidence="1">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="203" mass="23488" checksum="3802B7FFD35DB0EC" modified="2010-08-10" version="1">MKYARSSCMYSAVFFFLLLAWVPHAWCSDLEEAHEAYRSGNWHEAAELYRPLAEQGCDEAQNNLGELYSRGSGVKQDYDRAMEFFYLAAEQGNAYAQTNLGLHYSQGLGVRQNFARAHKWFEKGARQDNFVAQNALGLFYLHGRNLEKDYVLAYKWFYLSAQKGFDQAQENKRWTASRLSQEDLDKARKLAREFEPGFESGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST81</accession>
    <name>D6ST81_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="4" type="ORF">Dthio_PD1236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871246.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1236"/>
    <dbReference type="EnsemblBacteria" id="EFI33897">
        <property type="protein sequence ID" value="EFI33897"/>
        <property type="gene ID" value="Dthio_PD1236"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="75"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="182" mass="20344" checksum="F4D741E1F8EC26A2" modified="2010-08-10" version="1">MAQENQTLTHAYADTSYDEPIIDHAPVQKILNICRAMSLWPMTFGLACCAIEMMGFGMARFDSARFGAEVFRPSPRQSDLMIVAGTVNKKLSPLVTMLYEQMPSPKWVIAMGNCAISGGPFVYKNQYGIVEGVDRIIPVDVYVPGCPPRPEGLLEGLFQVQKKITGRRWWPVPETATKSEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST93</accession>
    <name>D6ST93_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OmpA/MotB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871258.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1248"/>
    <dbReference type="EnsemblBacteria" id="EFI33909">
        <property type="protein sequence ID" value="EFI33909"/>
        <property type="gene ID" value="Dthio_PD1248"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="113"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="274" mass="31790" checksum="F363341BECD15627" modified="2010-08-10" version="1">MPRSNRKKKEEDDDVEPWLLPFLSLMLLLLTVFVLLITYASFEDRRKIEMVMGAIQGTFGKGMGPGKVDVLDLMEIEGALEPGPFDEDVGDLKQLMPLLWDDKRKDLNFLEKRFVQIFSINTELLYEPGETELSSEGIEVLDKVVPVLKDLEYPVLLAGHTSLVRDEFGAGWQALKDDVIINPTWRLSLDRALNVYRYIMEQGVDPEMVRLEAFGEFQPRYGTRTEANRRQNRRVEIVLDRRNPSWKHLEAEEAGRRVPDDPDEVEYRDFIFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6STH9</accession>
    <name>D6STH9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Dthio_PD1334</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871344.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1334"/>
    <dbReference type="EnsemblBacteria" id="EFI33995">
        <property type="protein sequence ID" value="EFI33995"/>
        <property type="gene ID" value="Dthio_PD1334"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="467393at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="156"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="259"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFI33995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="589" mass="66519" checksum="438ED9075408E4FC" modified="2010-08-10" version="1">MASKIFKGIPVSAGLAIGRTYFLNREAGTSIVRINIVPEQVPQETARLKQGFNSALEELESILRKVPGDLKEQAAIIDSHIMILRDEKFQQSACDYVHSRLINAEWALDNAVSDIEKAFSRIEDEYIRSRTQDVRLVAGRVRSKLYGQSKSYDSKPERMILLAHDLSPADTIELKLDKIMAFATATGGKTSHAGIIARSLQIPAIVGAEGLEEIQDDHVVILDGFSGKIIVEPDAEELTHYTDLKQRFSEYYSQIKRNCYLPAETIDGYQMQVLANIELFEEVTSVIDNGGEGIGLYRTEYSFLNRNSWPSEEELYEEYRDMASIVYPQKVVFRTLDLGADKISPHFGPLEEVNPALGLRAIRFCQQNLGLFKAQLRAILRASTLGNVAVMFPMISGLQELREVKEIYFDVREEMRRQGQPFNEEVPFGIMIELPSAVFIADVLAREVDFFSIGTNDLIQYSLGIDRTNRYVSYLYQPLHPAILRSIKYVVDAGHEAGIEVNVCGEVAADPYCIPILMGMQLDSISLNPQAIPGIKRIIRQTTMDECKDLLKQVLSCSQVQQSNRLVREKIFTRFPEELMFYTSLIEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STS2</accession>
    <name>D6STS2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871437.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1428"/>
    <dbReference type="EnsemblBacteria" id="EFI34088">
        <property type="protein sequence ID" value="EFI34088"/>
        <property type="gene ID" value="Dthio_PD1428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1763493at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="215" mass="25450" checksum="2789A92BAB7A0FAC" modified="2010-08-10" version="1">MGCEIRIARTDSEKERIFRFRYKVYIEEMNRPAHADHDKRMITDWLDDTGTLIYAVDNGTVVGTVRVNLKRHGDIEFENEYDVRMFNPYYPKRLSSTTKFMVDPKYRGGTIMNRLIQYLYAYGLENGIYFDFINVNEPLFKFYSRLGYRSYKDNFHHPEFGEVVPMVLAMNDRHYLETVKSPLARFAAKYAASDRAGEDVRFFYREILGTDIPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STU1</accession>
    <name>D6STU1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gp157 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871456.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1447"/>
    <dbReference type="EnsemblBacteria" id="EFI34107">
        <property type="protein sequence ID" value="EFI34107"/>
        <property type="gene ID" value="Dthio_PD1447"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DHI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1870508at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008840">
        <property type="entry name" value="Sipho_Gp157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05565">
        <property type="entry name" value="Sipho_Gp157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="18842" checksum="7703B12D54BD8F77" modified="2010-08-10" version="1">MTTLADIEMEIANILATAEELSEDQQEVALEYLDELAIAEYEKIDAVGYAVRKRQSEIQFLKDEEVRLRNKRQAMEKRLSDFKAYLVELFQREEIHKIKGVSTTAYLRRSSSVEVTDISQLPSDYVETRIDFVPRKSQIRDALKQGQEIPGARMQEKQSLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6STY6</accession>
    <name>D6STY6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1494"/>
    <dbReference type="EnsemblBacteria" id="EFI34152">
        <property type="protein sequence ID" value="EFI34152"/>
        <property type="gene ID" value="Dthio_PD1494"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503343T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1954291at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="8409" checksum="8DEE40A2C9C21424" modified="2010-08-10" version="1">MKCHVCGGRMDSIRSDLPFKLDQHKIIVVKDMPVEQCQSCYEFLIQDPVMEYLDCLLDSVDSGIELEVRRFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU48</accession>
    <name>D6SU48_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871524.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0135"/>
    <dbReference type="EnsemblBacteria" id="EFI32828">
        <property type="protein sequence ID" value="EFI32828"/>
        <property type="gene ID" value="Dthio_PD0135"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032WJU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="139" mass="15912" checksum="7D5183DF93868846" modified="2010-08-10" version="1">MKIQTFEDLNAWKACRALRIFVSKQVKPSLPRYELYRLGDQLSRSSRSTTANIAEGYGRFHYMDNAKYCSNSRGSCWETLDHLITAHDEGFISDDILHQGRELVYTAVKLINGYMNYLQKAGKSNASTTKEDFAQYHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUG1</accession>
    <name>D6SUG1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871634.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0255"/>
    <dbReference type="EnsemblBacteria" id="EFI32941">
        <property type="protein sequence ID" value="EFI32941"/>
        <property type="gene ID" value="Dthio_PD0255"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="426"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="486"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="542"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="589" mass="66595" checksum="50EEFC71E714B801" modified="2010-08-10" version="1">MPLRFLWIFPAVFLLLSCASTPRDDSADLKPRTLEQSRILSHPELEVDADGISKEAEAAESMFRDEMDDLSPEEKAELQRTPLTEAEKEALETEIEFDFVLDARETQAMENYFKLYTHRYRNNFQAWLDRSEKYLPYIKEVFQERGLPEDLIYLPFAESGFNPRAYSRAGAAGIWQFMPGTGRMYDLRVDWWLDERRNPFLSTYAAADYLAKLYDEFECWYLALAAYNAGEGRVGRAMQRSGHDNYFDLINGPYLAMETRNYVPKFLAILKILRNLEELDFDPIDWDRAPDYRELEIPPGTDLIALSRAAGMEFDEFKEYNPAFRREVSPSDTRTQVMLPDTKAQAAAEFLDSPEAEQHAGYHRYQVSSGDSWWRISNRFGVPVSVLQEMNNTTSDMLRPGQYVFVPASGSTHAGSSTQDYAQRRGNYEVQSGDTLWDISRKFNVEMQTLIAANGLSGNTIRPGQKLYIPGHTQAGGGDEGSRVQTTYSVSSGDTLWEIARKFNVGMDDLRNANGLSGNTIRPGQELDIPGGGSGDSGGSVTTYQVRRGDTLSEIASRFGVSTRDLQNWNNLSSGQVIRPGDSLEVRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUM3</accession>
    <name>D6SUM3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">Dthio_PD0317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871696.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0317"/>
    <dbReference type="EnsemblBacteria" id="EFI33003">
        <property type="protein sequence ID" value="EFI33003"/>
        <property type="gene ID" value="Dthio_PD0317"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="13322" checksum="24F4A2DAE716818D" modified="2010-08-10" version="1">MIQVQTKLDVADNSGAKSVACIKVLGGSKRRYASIGDIVVVSVKDAMPRAKVKKGDIYKAVVVRTKKEVGRNDGSHIRFDNNSAVLLNKNMEPIGTRIFGPVARELRGRNFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUU0</accession>
    <name>D6SUU0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871763.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33070">
        <property type="protein sequence ID" value="EFI33070"/>
        <property type="gene ID" value="Dthio_PD0384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="228" mass="25858" checksum="9400091B9B21B7ED" modified="2010-08-10" version="1">MSQEAKILICGDPHGYFDYAARSAEEHGARAVIFAGDQCPPRPLEEIVAESGFTCPVYYILGNHDSDREEWLVNHLGMQEQNLHCRTVEIAGIKVAALGGVFRASVWHPRQEKAPRFYSRQAFLEHARPQTRFRHWLPRKHWTTIFPEDMDALRQQGNADILLCHEAPTTHRHGFEEIDQLAADLGVKMIIHGHHHRYYRSGLENGIQVTGLGISADGVFAFSREILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUY8</accession>
    <name>D6SUY8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871838.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0031"/>
    <dbReference type="EnsemblBacteria" id="EFI32744">
        <property type="protein sequence ID" value="EFI32744"/>
        <property type="gene ID" value="Dthio_PD0031"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="196" mass="22752" checksum="463DF8F13D8710DE" modified="2010-08-10" version="1">MVMPNQPRKGTSTKVEPIRRLEDIRAIKNLLQNEPRNLLLFTMGINNGLRIGDLLQLKVRDIQNLKVGDVHRVIEQKTGKENILLINKSTHKALRNYLEYKPGPDEYLFRSQRDKSSPITVSYANQVIKKWCKQINLTGNYGTHTLRKTFGYIQRVHYGVGFEILCKRFNHSSPTTTMRYLGIENKEVNNILMNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV18</accession>
    <name>D6SV18_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0067"/>
    <dbReference type="EnsemblBacteria" id="EFI32774">
        <property type="protein sequence ID" value="EFI32774"/>
        <property type="gene ID" value="Dthio_PD0067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="34991" checksum="E38FA901962E9DC5" modified="2010-08-10" version="1">MDSRWLSDYEQELIQQCKGLQPGRVKGWLVSEVSKFDNPPLRMTAEKIPYNVTWDGLAKKTRFLFRLCSSPEEKEFINAFYGALPFIRPPGHVVKSRSKYLNSLNYFDKFITCSLCWRIVPVCSENLKKPPFCDVHNPQFNRLEYQRAYRILGGKNKDHGKIVHLKSEVRDRLQDFMPDPGNMLYFFNDNFFRAPAPKKIIKKEHDLGEIMNRLPYLDSYIKNHALNPHCIEDLVHILSPPSTYETEEIPREKLNDCFIRDLGLAKKNILLAEAWIMATTKRRKSHGGYRKGAGRPQKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV33</accession>
    <name>D6SV33_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871876.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0087"/>
    <dbReference type="EnsemblBacteria" id="EFI32789">
        <property type="protein sequence ID" value="EFI32789"/>
        <property type="gene ID" value="Dthio_PD0087"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="35630" checksum="90A6E350ABCB7343" modified="2010-08-10" version="1">MPRIARFIRNDRQTVYHVISRTALPGLPIKDTDKDYLLGLIKRLSRLYFVDVLGFAVMGNHFHLVARMHPEDEISNSDIIKRWQDYYGDKVEMPTDRMAEVKKRLCSLGAYVKDIKQNFTRYYNKKHRRKGFFWGGRFKSMIVQEGSTLVNLLAYVDLNPIRAGIVKKPENYRWSSLGYHTQTGNKDGLLDIDFGLKEWNELDPKEIVRKYRQFVYETGAVDAGKGKTIDQKVVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDTRKFTPVGGVEGLYSMKRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV51</accession>
    <name>D6SV51_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32807">
        <property type="protein sequence ID" value="EFI32807"/>
        <property type="gene ID" value="Dthio_PD0109"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZZMJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025639">
        <property type="entry name" value="DUF4338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14236">
        <property type="entry name" value="DUF4338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4338" evidence="1">
        <location>
            <begin position="16"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="166" mass="19093" checksum="6C3F440763D6E7D4" modified="2010-08-10" version="1">MRLPPLVVGLCVGNCQMPYGARLQYLIHTGRPRRELVACVQFSSPAWRIKVRDQWIGWDDSTRSKRLQHVVNNSRFLILARIKNLASMALSRALQHLSVDWFERYGLEPLLVETLVDRQRFLGVAIWLPTGNCLVIPVAGAVRIELANVMAQQLKRCWSFPWSRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV60</accession>
    <name>D6SV60_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0118"/>
    <dbReference type="EnsemblBacteria" id="EFI32816">
        <property type="protein sequence ID" value="EFI32816"/>
        <property type="gene ID" value="Dthio_PD0118"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031IUH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="65" mass="7877" checksum="1A83C15082FAE8D4" modified="2010-08-10" version="1">MNHNDTLRPEYPSELIKSGERGKFAKKYREERTNLVYIEPDLFKFFPDSESVNRALRKYFNEHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJQ0</accession>
    <name>D6SJQ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36103">
        <property type="protein sequence ID" value="EFI36103"/>
        <property type="gene ID" value="Dthio_PD3552"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033JPR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="11109" checksum="C3787A0A86556BCA" modified="2010-08-10" version="1">MLYYDYGIEMVFFKINLKICNGQESGDRDQGSGDRRQETGDRSQETGIRDQETGIRDQETGIRDQETGIRGQGTRVRNQWSGSRNIIIRDGEMVVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJR9</accession>
    <name>D6SJR9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869247.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3575"/>
    <dbReference type="EnsemblBacteria" id="EFI36122">
        <property type="protein sequence ID" value="EFI36122"/>
        <property type="gene ID" value="Dthio_PD3575"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031BBY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635639at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015207">
        <property type="entry name" value="DUF1931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09123">
        <property type="entry name" value="DUF1931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="17120" checksum="3FD4BA2C7A34F895" modified="2010-08-10" version="1">MTQIFGGKKFEALFRNAAGLDMDKSDLKRLYEVVNQKMHDMLEMGVVTAQANGRDVIQFYDLPITMAFKEQLREVREYDETLNLEPILEQLATLPKLKLDYSSEVENALPELTGAITVALAKMFKAVNPELKNPKPQDWEKVISVFNILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJU7</accession>
    <name>D6SJU7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869275.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3604"/>
    <dbReference type="EnsemblBacteria" id="EFI36150">
        <property type="protein sequence ID" value="EFI36150"/>
        <property type="gene ID" value="Dthio_PD3604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="16391" checksum="57F46F75F75CFCD2" modified="2010-08-10" version="1">MQDETGITLVEVLISLLILLVGILAVLTMHTTSVQNNKVAREMTEAMHHANKELEIIIAKDFLDLDTNIYPKQIQSNISNIKYEIDIEADDKDLNNILFSSLDIDDIDYLFAFELIVSWRSFGKEREIVFPFKKSSVGMSPTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJW1</accession>
    <name>D6SJW1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869286.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3620"/>
    <dbReference type="EnsemblBacteria" id="EFI36164">
        <property type="protein sequence ID" value="EFI36164"/>
        <property type="gene ID" value="Dthio_PD3620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8029" checksum="D187F1A3267B3EAA" modified="2010-08-10" version="1">MDTILFRDKRVAAVDFDDPESVIVCLQNGWCVFEPGLHIFGEDSIAQAVQTLQDFVQPCNCPDCRQGLVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJW2</accession>
    <name>D6SJW2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869287.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3621"/>
    <dbReference type="EnsemblBacteria" id="EFI36165">
        <property type="protein sequence ID" value="EFI36165"/>
        <property type="gene ID" value="Dthio_PD3621"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2098459at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="65" mass="7773" checksum="273798F6125196D5" modified="2010-08-10" version="1">MAYTPELSRIHSRTLKRIAWATGKPMTRTLELIFDWLPDRMDEVKVCSHCRDREFCNECPFNKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJW7</accession>
    <name>D6SJW7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869292.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3626"/>
    <dbReference type="EnsemblBacteria" id="EFI36170">
        <property type="protein sequence ID" value="EFI36170"/>
        <property type="gene ID" value="Dthio_PD3626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="10887" checksum="9BA4BAEDA6CEB1A3" modified="2010-08-10" version="1">MQTINPMDTGYSFRGFYIPAYMLDALERYIHQGQPPGDFLSAVISNDLTKAIARADDHNQVNLPAYIAYLHNEAPGVCWGSPEKMKTWIEAKKLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK25</accession>
    <name>D6SK25_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869350.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3685"/>
    <dbReference type="EnsemblBacteria" id="EFI36228">
        <property type="protein sequence ID" value="EFI36228"/>
        <property type="gene ID" value="Dthio_PD3685"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1986748at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="12082" checksum="5608E525408E0662" modified="2010-08-10" version="1">MDDKLHSATQVVQECFWGDYLVTPQDILERLEKKDAAFGRFLFSKIIENSRHPSKHLKVLFPMEDLLPMLDRYLSMSGGKKRVRLVAANITGDHSLVPELQWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK38</accession>
    <name>D6SK38_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3698"/>
    <dbReference type="EnsemblBacteria" id="EFI36241">
        <property type="protein sequence ID" value="EFI36241"/>
        <property type="gene ID" value="Dthio_PD3698"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="161" mass="18046" checksum="B46213B90DB5A538" modified="2010-08-10" version="1">MPSYNYFPESKSSCQGLTLIELLVILAILGIIISIMGMNLRPFGNDLENATQETAGFFKQTRVKAISSTSAYRVIFNTDNHLIVEHAIFCKDEEGWQRDAKLDLELREGVVFNSKDFTNEEVLLCFNSRGFSTENIELEIVDAKNNSKALEVYLGGAVVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK56</accession>
    <name>D6SK56_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869378.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3722"/>
    <dbReference type="EnsemblBacteria" id="EFI36259">
        <property type="protein sequence ID" value="EFI36259"/>
        <property type="gene ID" value="Dthio_PD3722"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8332" checksum="25DCECEC69D175E9" modified="2010-08-10" version="1">MMVNVHEAKTNFSNLLEMAHAGQEIILAKSGKPYALLTPLPSGGVAQRKPGRLPGKVTESFFEPLPEEEIAAWERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK69</accession>
    <name>D6SK69_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbfA</name>
        <name evidence="3" type="ORF">Dthio_PD3735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RbfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869391.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3735"/>
    <dbReference type="EnsemblBacteria" id="EFI36272">
        <property type="protein sequence ID" value="EFI36272"/>
        <property type="gene ID" value="Dthio_PD3735"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="109" mass="12561" checksum="04001CA107FE1185" modified="2010-08-10" version="1">MQPATSRRATRMADSIMRELGRIIVEEARDPRLNLVTITGVLMNKDLSIARVMYTHIQGPSPELEKALGSARGFLRSSLGQNLKMRYVPELRFEWDTYLQEMVYDSRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK87</accession>
    <name>D6SK87_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="6" type="ORF">Dthio_PD3753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869409.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3753"/>
    <dbReference type="EnsemblBacteria" id="EFI36290">
        <property type="protein sequence ID" value="EFI36290"/>
        <property type="gene ID" value="Dthio_PD3753"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="30"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="36"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="273"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="415" mass="46673" checksum="B67A503C67F23E39" modified="2010-08-10" version="1">MNFFEYRNGELYAEDISIKELVQEFDTPLYVYSAKTLRRHYEAFDSAFEGTRHMTCFSVKANSNICVLKLLGQMGAGVDIVSGGELFRALKAGIDPQKIVYSGVGKREHEIREALLSNILMFNVESRQELERINQVASEMEVQARISLRINPDVDPQTHPYISTGLKKNKFGLELEQAWESYKLARELSNIEPVGIDCHIGSQLTSVEPFLEALERIKSFYGRLQELGLDIKYLDLGGGLGITYDQEEPPHPAEFGRAVKESLKDTDLTLILEPGRVIAGNAGIMVTRVLYTKGTPSKNFVIVDAAMNDLMRPSLYGSYHRIEPVQEKSGRLYTADVVGPICETGDFLAQGRELPRLEQDDLLAVHSAGAYGFTMASQYNSRPRPAEVLVDNDQAVLARRREVYFDLLQLEEQCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKI8</accession>
    <name>D6SKI8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35199">
        <property type="protein sequence ID" value="EFI35199"/>
        <property type="gene ID" value="Dthio_PD2607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="75" mass="8994" checksum="568A0B7542670598" modified="2010-08-10" version="1">MWSYQMKNDSIILKEALDLLNEKMNPAEVERFIMLVNNQGFDYTKWRENLWEDVDSLETLSSKAQKFYERNEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKJ2</accession>
    <name>D6SKJ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868337.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2611"/>
    <dbReference type="EnsemblBacteria" id="EFI35203">
        <property type="protein sequence ID" value="EFI35203"/>
        <property type="gene ID" value="Dthio_PD2611"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033BH9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2057405at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032568">
        <property type="entry name" value="DUF4926"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16277">
        <property type="entry name" value="DUF4926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8234" checksum="6D9A6BA8804C3864" modified="2010-08-10" version="1">MIKEHENAVLTVDLPSTGLMAGDVGVVVHVYELGKAYEVEFIALDGNTVAVETLDAGKIRPVQEREMLHVRDMAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKK0</accession>
    <name>D6SKK0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopG domain protein DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868345.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2620"/>
    <dbReference type="EnsemblBacteria" id="EFI35211">
        <property type="protein sequence ID" value="EFI35211"/>
        <property type="gene ID" value="Dthio_PD2620"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2054325at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038733">
        <property type="entry name" value="Predicted_DNA_bind_prot_RHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12651">
        <property type="entry name" value="RHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9800" checksum="CF6D5481EC154868" modified="2010-08-10" version="1">MQMTIRMPDEYRSRIEEVSEKTGLKKSDIARMAIKKFLEDFDVQARGDRTSAKAQDLIGVVNSGIPDLGTNHRRHLLNLMRDQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKP1</accession>
    <name>D6SKP1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system F domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2663"/>
    <dbReference type="EnsemblBacteria" id="EFI35252">
        <property type="protein sequence ID" value="EFI35252"/>
        <property type="gene ID" value="Dthio_PD2663"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="75"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="277"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="409" mass="46069" checksum="00062923E4F90E97" modified="2010-08-10" version="1">MAVFQYKMLNTEGLLERKTENLPLEALEEAVRYLERQGATVLTIRRLPYWLNPVVQAYMHGFSRIKRAELAEMFNSLAVLLGARVNVLTALNEVSQGIKNPRLLSIVNFIIVDISNGQTFSKAIARHGRTFSPIICQMARIGEETGTLDQMLRKVADYLRQVDHVVGETKRALIYPALVLLVISGAVIFWLWYVVPQIVELFHEFGVEVPDITRFLIFMSSLVQNWMGPAVVFALFSAALLMGLRRLYRPRYAMDWLILKMPVISGIIHASSVARITENLGVLTASGVTVLRSLEIIRDSIENEVIKKRFEHVEHEIILGNNLSGALKRASAVEAMVVRMIAAGEATSSLEQQAFYVARQYRQRLDYLVQNMSKVLEPALLIVMGLFFALIVAGLLFPLYEMIGDTGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKQ9</accession>
    <name>D6SKQ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35270">
        <property type="protein sequence ID" value="EFI35270"/>
        <property type="gene ID" value="Dthio_PD2681"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RQ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022265">
        <property type="entry name" value="CHP03790"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03790">
        <property type="entry name" value="TIGR03790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="222" mass="25097" checksum="9427273457B6907E" modified="2010-08-10" version="1">MFINRYGFVFLMIVVVMAVSFLQQKEAGASLKPEEILVVANKIQTEEAGLQGRAYFDARWPMPDERPQGGYGLYDYSLHQAALHLQSNDIMPVTVEETSALFQPGDCPEAALYAGWYSLARYVPAFEWQPGSVGYHIASQECQSLRRGEYWCKRMLEEGVAATLGPVGEPYVQAFPPPEIFLPCLRTGVLVWQKSILIPYHPGPGRWSWWEIRCTGRSRISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKT4</accession>
    <name>D6SKT4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system F domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2709"/>
    <dbReference type="EnsemblBacteria" id="EFI35295">
        <property type="protein sequence ID" value="EFI35295"/>
        <property type="gene ID" value="Dthio_PD2709"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="288"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="46788" checksum="998C32598F79A468" modified="2010-08-10" version="1">MEFTYRASTLEGRVHQGRIDASDKKQAAASLHARNLIPLSIEPLDRQAINSEFRSQNRIKYAWLYLHSLDAFARGKIGTKDLTAFTEHLGAMLKAGITMNKSLALLGDLTENRSLARVIKDVHSRIREGSHLYQALEEHPEVFPEVFINMVRAGESGGILDVILERLSEFMNEMARLREHLVSSMIYPAILGLTAAASMLVMLVVVIPRFADIFVDMGIEMPQATRVMLWCGNFIVHYWWALGLGAVLCLLMLKYLRSTSGGRLFWDRLRMRLPLLGTIFLKLELARFSRTLGTLLNSGVSILEAMNIVSGVVGNTVLKNRLAVVYDDLKQGRMLSGSLEQHGIFPPLAVNMLRVGEESGEMAVMLEKVGDMYDRDLRRAVKSFTSIFEPAVILVMGLVIGVMVVSMLMAVFSLNEMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKX3</accession>
    <name>D6SKX3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868466.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2749"/>
    <dbReference type="EnsemblBacteria" id="EFI35334">
        <property type="protein sequence ID" value="EFI35334"/>
        <property type="gene ID" value="Dthio_PD2749"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="442" mass="50240" checksum="56CD018C1ADA1BD6" modified="2010-08-10" version="1">MSEAATAKRIADPGLDQSIEKLTPDRIEATILRVINQENSARLKTFVDTCVHCALCSEACHYFMSYDRNPRYAPVGKVKNTLWEMIRCKGKVSKEFIRDAAQIAYTECNLCKRCVHFCPFGIDTAYLMTIVRRICHLLGVTPQYLQDTSHSHSATFNQMWVKDDEWMDTLQWQEEEARDEFPGLRIPLDKEGADIMYSVIAPEPKFRAQLIYQAAAIFHEAGSDWTMPASPGWDNSDMAMFSGDAEMMGRLKRKHFDTARRLRVKKIVMGECGHAYRSVYDMGNRWLGYKEMPIPIIHAIQFYCELLRAGKIKVGSKIKELCTFHDPCNTVRGMGLHEMGREVARAFCPNMVEMHPNREHNYCCCAGGGVINCGPPHKMTRVHGNSIKAEQLKATGAKIVIAPCHNCHGGLEDIIHHYKLDMKLMFLGDIIFEHMQKPGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKY8</accession>
    <name>D6SKY8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="13" type="ORF">Dthio_PD2764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868481.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2764"/>
    <dbReference type="EnsemblBacteria" id="EFI35349">
        <property type="protein sequence ID" value="EFI35349"/>
        <property type="gene ID" value="Dthio_PD2764"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="50"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="388" mass="41918" checksum="505B744614F32BF6" modified="2010-08-10" version="1">MRKGYFGAFGGRFVPELLVPPLAELEEAVDNILPSEAFVKDMDRVGREFVGRPTPLYPCRNLSGELGFDVYLKREDLAHTGAHKINNTVGQALLARHMGKRCLLAETGAGQHGVATATAAAMLGLDCIVFMGALDVQRQSINVHRMELMGAKVEPVESGTRTLKDAINAALRYWIAHQSDTHYCLGSAVGPHPFPLLVRKLQSVIGRESRQQMLEQTGNLPDTVVACVGGGSNAIGMFHPFVEDRQVELVGVEAGGRGGPEDYHSATISRGTPGVLHGTHTFLLQSTEGQILPSHSVAPGLDYPGVGPEHSFLKDSSRARYEVIHDREALKAFNLLSRKEGIIPALESAHAVAWAVENKESIKQGSKVLINLSGRGDKDLDIVRDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL15</accession>
    <name>D6SL15_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868508.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2792"/>
    <dbReference type="EnsemblBacteria" id="EFI35376">
        <property type="protein sequence ID" value="EFI35376"/>
        <property type="gene ID" value="Dthio_PD2792"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="142" mass="16460" checksum="12D5D5C05DD52816" modified="2010-08-10" version="1">MKVLIAEDEFYNRWVLSKMMASYGNCIETDNGEEAVQTFCWACRKKEPYDLVLLDIMMPALNGFEVLERIRAFEKESGIENLQKTKIVMLTSLEEPEYIDQALNEYGADSYLTKPVQLETLRQVLTDLGFFPQELDMQQEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL21</accession>
    <name>D6SL21_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868514.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2798"/>
    <dbReference type="EnsemblBacteria" id="EFI35382">
        <property type="protein sequence ID" value="EFI35382"/>
        <property type="gene ID" value="Dthio_PD2798"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="84"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="28368" checksum="7DD29FD7582B5CFF" modified="2010-08-10" version="1">MEVLFVLKKVVSRLVFPLPLALQVILLGLIFIIFKRNRTGFVFILAGTVFLGAISVEPVADRMLRPLEQKYQPLQYDDTSAPSYIVVLGSGHFLQEGLPPNALLSQSSLSRVVEGIRIKNMYPDSTLVFTGGRFRYPVASSELAALASVELGIDENDILVVAEAKDTEDEASLARDIVGDESFVLVTSASHMHRSMIIFKSEGMDPIPSPTDFRAPDKLYNLWDYFPSAGALAKTERVFYERLGLAWAMIRGIVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLA4</accession>
    <name>D6SLA4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD2885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868597.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2885"/>
    <dbReference type="EnsemblBacteria" id="EFI35465">
        <property type="protein sequence ID" value="EFI35465"/>
        <property type="gene ID" value="Dthio_PD2885"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="577"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="617"/>
            <end position="624"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI35465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="916" mass="100808" checksum="C87D2122EF08B881" modified="2010-08-10" version="1">MENSIRISGARQHNLKSLSLEIPRNKLVVLCGPSGSGKSTLAFDIIYAEGQRRYVESLSVYARQFLPQMDKPLVDKIEGLSPAISIEQHTLSRNPRSTVGTVTEVYDFLRVFYARLGTSTCPECGLEVQAQSASRIIEHIMDMPQGTKFMILSPLVNNKKGTHQELLKKLKSQGFVRVRINGEVQSLDTLPALDKNRKHRIELVVDRLVHKPDMRKRLADSVELALAYGQDSLLVSIVDGRDIFYSTQAVCPDCKISMPAPSPQLFSFNSPQGACPECSGIGSVEYFEPDLIAPNKGLSLNRGAIIPWKKPAVFARYKDDLLALGRKYGFDLDTRLADFPPEALEALFAGDKELGFEGVLSLLEEGFAIGPVWRDELARYRQSRPCPVCRGARLRPESLSVHVNGKNIYEFTRLSIHKALEWLQSLKFEQSQARIAEPLINELSHRLKFLVNVGLDYINLARNMSTLSGGEAQRIRLAGQLGSGLVGVTYVLDEPSIGLHPRDNDRLLSTLRELQGRGNTVLVVEHDEATIRSADHVLELGPGSGALGGEVVHQGSVDALLGSNTLTGKYLRREMTIPRPDKRRNSGRCLTLRGVSTNNLKNVDCDIPLNQLVVVTGVSGSGKSSLVVDSLYKHLALARGLKVDEPGSIAGIEGAEHIAKVVPIDQSPIGRTPRSNPATYTKVFDEIRNIFAETKDARKRGYKPGRFSFNVRGGRCESCSGDGQIRVEMHFLPDVFVTCEVCGGQRYNRETLDIEYRGYNIAQVLDMSVAQARVFFQNYPVLERKLGILEEVGLEYLRLGQPATTLSGGEAQRIKISRELSKKSLPGTLYVLDEPTTGLHTHEVGKLIQVLNQLVDKGASIIVIEHNLDVVACADYLLDLGPGGGDSGGYIVARGTPEEVRDNPGSVTGRFLSLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLC3</accession>
    <name>D6SLC3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2907"/>
    <dbReference type="EnsemblBacteria" id="EFI35484">
        <property type="protein sequence ID" value="EFI35484"/>
        <property type="gene ID" value="Dthio_PD2907"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016468at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087862" evidence="3">
        <location>
            <begin position="27"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="186" mass="21066" checksum="B382CF7678A2A09F" modified="2010-08-10" version="1">MSSMFKPVSVLIICLVLSACSMPRIAVLSDPLTAGEHNDLGVSYELMGEMELALKQYELAYENDREWDQPLINHGNVHAGLENWERAEESYRKALERSPDNPEAMNNLAYVLMKQDKNDDALDWSAKAVKIQPENPAFLNTHARACLKTGNPDKAKRIFTRALSQLPDEDPLRERVKEGLKEVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLE5</accession>
    <name>D6SLE5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycolate oxidase iron-sulfur subunit</fullName>
            <ecNumber evidence="4">1.1.99.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-lactate + A = AH2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15089"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>A + glycolate = AH2 + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:21264"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="1.1.99.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 2 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.14" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868638.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2930"/>
    <dbReference type="EnsemblBacteria" id="EFI35506">
        <property type="protein sequence ID" value="EFI35506"/>
        <property type="gene ID" value="Dthio_PD2930"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012257">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000139">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="423" mass="46096" checksum="36C505D15CA7EF31" modified="2010-08-10" version="1">MADIKQLSRMLQELDDLLTRCMRCGMCQAQCPVFTKSGKETDVTRGKLALLSGLSQEMLKDPKEVQDNLNRCLLCGTCEANCPSGVKVTDIFLKARAILNGYLGLSSTQRLIFRRLLTRPKLMNALISMSSAFQGVFSKDADQIIGTSCARFNAPLIRDRHFKKLAGKPLHRQVPSLDTPAGSSGIKVAFFPGCVTDKVFPDVGQAVIKILKHHQVGIYMPENQACCGIPALSSGESDAFSTMVRQNVELFSAGKWDYLITPCATCTATMRKLWPEYHKGSLGRVITENILDVSQFLVDVLGVKPETSDNRKTPVAYHDPCHLRNSLKVSAQPRAVLEAGGTYKTAEIPGGPSCCGSGGSFNIKHYQLSKDIGQEKARNIKASGAEMAATACPACMLQLADMLSQEEASMPVKHVLELYAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLH4</accession>
    <name>D6SLH4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868667.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2959"/>
    <dbReference type="EnsemblBacteria" id="EFI35535">
        <property type="protein sequence ID" value="EFI35535"/>
        <property type="gene ID" value="Dthio_PD2959"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="83"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="TSPc" evidence="3">
        <location>
            <begin position="142"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="456" mass="50017" checksum="6E8CF6A1DEA3EEAE" modified="2010-08-10" version="1">MKKHLPWLFLLLFFFPADLAAKPLLEEIRQVLRQHLPDPPDEALLQSLSKDTLQDDLQSLDAYARYFAKGESVHQTALEAQYTGIGAEIFSRDEEILVSPYQDGPLARAGVTERSVLLEVNGIRVAGEELEKAAAMLQGPPGKMVDLKLRPLSGEDMVELRVKREAVRPLHVELLQPQDQAVLRIRDFAAGRTRASLRVSIDYLGAGSSPVFIDLRESTGGDLFEALDCAALFIEPGKSLGGLWTKKSGKTLVNSPPGEKLSGRIVVFTGPDTASAAEAFAAALKFHGKALLAGEPSYGKCSTQTRISLSDGSVLQMTNGYVLGPEETPCSPEGLQPDIKVAGSRLYDTAYLVREGLAALEAQDALPETRQQYTLQQLAEEDLLTVRALRAWDRLPSGYVSLVLNLVEHDMDLLGANQVQVRIWSDKARNSDDPDLARHAGELESLAEYMEKSSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLH5</accession>
    <name>D6SLH5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868668.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2960"/>
    <dbReference type="EnsemblBacteria" id="EFI35536">
        <property type="protein sequence ID" value="EFI35536"/>
        <property type="gene ID" value="Dthio_PD2960"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ANP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016729at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="185" mass="21033" checksum="2D71B2CD5B349F05" modified="2010-08-10" version="1">MRYLYLPVLICVLLFAGCGASQDPREGGFFGGISGLGSGAYEERVEEREQRLSRLQQIQKDLDAESREIDAQKTDLREQIELERAHLEEMQNSTARLEQEVSRMSAGDAAGEKKVNELRSRLNDLQSGLQKQEQELSALDQLEGTHGHGDAGEEVDLRRRQLEEQRRYLQEEYELLLELALELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLM5</accession>
    <name>D6SLM5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS66 Orf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0845</name>
        <name evidence="2" type="ORF">Dthio_PD3014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868715.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0845"/>
    <dbReference type="EnsemblBacteria" id="EFI33511">
        <property type="protein sequence ID" value="EFI33511"/>
        <property type="gene ID" value="Dthio_PD0845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35586">
        <property type="protein sequence ID" value="EFI35586"/>
        <property type="gene ID" value="Dthio_PD3014"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1680806at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="13910" checksum="B733A6BDFAD2A890" modified="2010-08-10" version="1">MIQLTPQMRILVAVEPVDFRKGIDGLTKICRQRIKSDPFSGCVFVFCNKKKTAIKIITYDGQGFWMCQKRLSQGRFQWWPDKSQSGICPLAVHELQLLIWNGNPQNAQVAPQWRKILTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLN0</accession>
    <name>D6SLN0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrite reductase (cytochrome; ammonia-forming)</fullName>
            <ecNumber evidence="2">1.7.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:13089"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome c-552 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868720.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3019"/>
    <dbReference type="EnsemblBacteria" id="EFI35591">
        <property type="protein sequence ID" value="EFI35591"/>
        <property type="gene ID" value="Dthio_PD3019"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042279">
        <property type="term" value="F:nitrite reductase (cytochrome, ammonia-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00548">
        <property type="entry name" value="NrfA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003321">
        <property type="entry name" value="Cyt_c552"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30633">
        <property type="entry name" value="PTHR30633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02335">
        <property type="entry name" value="Cytochrom_C552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000243">
        <property type="entry name" value="Cyt_c552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087973" description="Nitrite reductase (cytochrome; ammonia-forming)" evidence="9">
        <location>
            <begin position="20"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="522" mass="60846" checksum="094C96BA8368C6D9" modified="2010-08-10" version="1">MSKKYLSWVLALMLTLVFAGCSEIPEAETPDYETDLTEEEAERNSAFKEYFPKQYQTYQRLKAEDFDYGEGQMTEYGGSVAHEKHLCGDLPQAYKYCQPYLKNLWLGYPFSYEYNRARGHANAVHDLLDIDRINRYSEEAGLPATCYNCKSNKMPGYIEEYGDDFWAMEFHDFREEHDLEDHAIGCNTCHDPEDMSLRITSVPLTEALERQGEDWRDASRNEMRSLVCAQCHVEYYFEHEEIGVAQKPVFPWDKGKNPDDMYEYKKSFGVTDREGFEGWFIDWTHPVSDTPMIKVQHPEYEMWHDSTHGAAGVACADCHMPYTRMDGKKKISSHFQTSPLRSMEAIENTCGQCHTDKSAEYLKDRVIYSQERTWEQLMEAQRESVRAHEAVRLASEYEGDVRNDFDDLMIQARERVRKGQWFWDYVSAENSAGFHNPAKAIDTLSKSQKYSRQAVQYAMQATNYGIAPDLEGDIKDIVPPIEEHSRELHMDPEHLETHEWLQYLEPHPEGDLIWDLNEKVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLV0</accession>
    <name>D6SLV0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868790.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3090"/>
    <dbReference type="EnsemblBacteria" id="EFI35661">
        <property type="protein sequence ID" value="EFI35661"/>
        <property type="gene ID" value="Dthio_PD3090"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="433"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="538" mass="60035" checksum="104B34A39DBE0D81" modified="2010-08-10" version="1">MERVLVTGYGYPAYKAAQLVKKLKPEVDLLWITEYSEEKYPLEMVELLLGLGESPADWSRIRARVKTDFEKNTRMPVIAPVRVKKIRFDLQAREVSFLSNTGNMNYFFDQAFIFPEPAFQAPRFAPSGGLLWPQSSCVEHVVNNWGHLEAIQVVGNDMSAVQALACGEKSFEWVRSQNFFSRQVQFFVDEYLKSRGGSISICSDLDRESPETEHEETGRTVVYCSRPVLDLERLKAMGIDSPVEYLQDSGVYIQDNICIAAPYAARDYPRHPTSMEYSLQTGLFAVQSLLGDDPPRPPQKNTRSWNMAGLHAGSAGLNPQQALEKGFSPEWAIVSGADHPLKEAGHVLHLTVDKDSRRILGAECAGREAAAWVDMVGHLVQENAVLEDLVKQEMVSFGFGLHPLKKCARILENKLGSRILGINPTELEESYNQGAEFFLLDVRSPEEYQRIRISGAENIPLPELKKKAVQIPRFVPLVLYSRCSGRAYQGARLLQSMGAKQLYVLDGGMELWPLANETEQEAGSGPIVVPSGCSISCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLW8</accession>
    <name>D6SLW8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Succinate dehydrogenase or fumarate reductase, flavoprotein subunit</fullName>
            <ecNumber evidence="13">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="13"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868808.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3108"/>
    <dbReference type="EnsemblBacteria" id="EFI35679">
        <property type="protein sequence ID" value="EFI35679"/>
        <property type="gene ID" value="Dthio_PD3108"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="7"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="468"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="606" mass="66221" checksum="665AB55A57C3CD9D" modified="2010-08-10" version="1">MRIIYTDLLCIGAGLAGERVAIEAARAGFETICLSLVPPRRSHSSAAQGGMQAALGNCIKGDGDCPDVHFQDTVKGSDWGCDQEVARMFADNAPLAIRQMDHWGVPWNRVVPGKSCYYKGGEKLEKEESEDKSGLITARDFGGTAKWRACYCSDGTGHAMLYTMDSVAVQHGVQVHDRTEALSLIHDQERCHGAVVRCLKTGELRAYISRATLIASGGFGRIYRASTNAVINEGGGQIIALDTGVVPLGNMEAVQFHPTGIVPTDILVTEGCRGDGGTLLDVNLERFMPQYEPEKAELASRDVVSRRMQEHMVKGMGVKSPYGEYLWLDIRHLGREHITTKLREVDEICKNFLGVDPAESLIPVRPTQHYSMGGVRTDKNGAAYGLKGLFSAGEAACWDMHGFNRLGGNSLAETVVAGMLVGRSVAGFLQEEDMRVDTALVRGELKKQQERIDGLKSSTRGEAPFEVRNRMQDILMDYVGIFRNEKDLHLAVEKLQQVLQSAENLKLSSSGAGASPELSLALRLPGMVRLALCVAFGALERRESRGSHAREDYPARNDRDWLVRTLAFWPGGRALPRLEYEPATKVVEIPPGDRGYGGCEVISAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM21</accession>
    <name>D6SM21_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polynucleotide adenylyltransferase region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868861.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3161"/>
    <dbReference type="EnsemblBacteria" id="EFI35732">
        <property type="protein sequence ID" value="EFI35732"/>
        <property type="gene ID" value="Dthio_PD3161"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="324"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="388"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="898" mass="101840" checksum="3A36BF5482B6616C" modified="2010-08-10" version="1">MQKKDKLKAPTVITCHVNADFDALSSMIAASKMYPEAVLIFPGSQEKNLKNFFIQSATYLYNFKSFKDIDPESVQRLVVVDTRQKSRVRHVEQLLDKEDLSIHLYDHHPDSEEDLKGDLEEVHPWGSTISVISRLLKDQQIQLTDDEATIMGLGVYEDTGCFTFRSTTTHDFSAASWLLSQGMDLNVVSDLITRDLSAEQVSILNSMLEAATTHKIKGIDVVVTEISLDHYVGDFALLAHKLLDMENIRVLFALGRMHDRVHLVARSRTADVDVGQICSSMGGGGHSFAASANLKHKTLTQVKDELFGLLYSQINPQILVSDLMSRPAVTIEENKSINLASEVMTRFGLKAIPVTDKNGRECVGILEHQLADKAIGHGLGEIPLSEYMISNVFSLTPGDDIYQVMEIIIGQRQRLIPVMENGAITGVVTRTDLINNLINEPARIPESLLPEKKRERNIRRMLKERLPGEIYSLLKSAGHQARDMGYQVYCVGGFVRDILLGRSNLDVDLVVEGDGIKFARALAEKLDARVREHQKFRTAVIICADGRKIDVATARLEYYEHPAALPMVELSSIKMDLYRRDFSINALAVHLNPQNMGRLVDFFGGQRDLKDKVIRVLHSLSFVEDPTRIVRAIRFEQRFGFRIGAQTEKLIKNALELNIFHQLSGSRIFHELQMIFEEDTPLPCLIRMENYGLLKHIHPMLKLSSNVKNILTETEKVINWFQLLYLEEKIDKWILYMLGLLNHINEVQAGIIMQRFNFSQKKTRHIFSLRSQINSAMSSISAWHQDQGKLSSLYFILNPLPLEGLLFLMARVQKEELRKYVSHYITHLRDIQPQISGRDLKKMGLTPGPEFGRILKELKAAQIDGVACDRQEQKEWVRQKIAEQSLQGGKEKRASGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM34</accession>
    <name>D6SM34_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ste24 endopeptidase</fullName>
            <ecNumber evidence="12">3.4.24.84</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD3174</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="12"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868874.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3174"/>
    <dbReference type="EnsemblBacteria" id="EFI35745">
        <property type="protein sequence ID" value="EFI35745"/>
        <property type="gene ID" value="Dthio_PD3174"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="11">
        <location>
            <begin position="31"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="209"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="428" mass="48285" checksum="F4E63519648F2EB2" modified="2010-08-10" version="1">MQTIIFLGAAALLAARACWQTVLAVLNRTRVLSLRHHPPESVFRVMDRETYDKSVDYTLAKNRFELWSIWYGTVILAVLLFSGIVPWFYHNLFESGSELHILNESLFLAAVYVVFFLAGLPLDFYSSFRLEERFGFNKSTMGLWISDQFKSLVIALVITVPLLSLIIWLIIMAGSLWWVWAFALVSLFQLVMMVLYPMLILPLFNRLTPLPDEELRQRLMNLADRAGFKARTIQVMDGSKRSGHSNAFFTGFGRFRRIVFFDTLIEQLEPRELEAVLAHEIGHYKKGHVPRMLAISAAMFLAGFALAAWLLETPAFIQAFGFQPEHAGPGPALLLFALLAGVVAFWLSPLMGALSRKHEYQADSFAAKQLGDVQPMIRALTRLGTENLANLTPHPLYSGFYYSHPTLMERIGALEQAAEGKEKAPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM79</accession>
    <name>D6SM79_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868919.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3225"/>
    <dbReference type="EnsemblBacteria" id="EFI35790">
        <property type="protein sequence ID" value="EFI35790"/>
        <property type="gene ID" value="Dthio_PD3225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="875842at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046356">
        <property type="term" value="P:acetyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016041">
        <property type="entry name" value="Ac-CoA_synth_d_su_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016218">
        <property type="entry name" value="AcylCoA_decarb/synth_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03599">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000376">
        <property type="entry name" value="AcCoA_decarb_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>5-methoxybenzimidazolylcob(I)amide</name>
            <dbReference type="ChEBI" id="CHEBI:157765"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>5-methoxybenzimidazolylcob(I)amide</name>
            <dbReference type="ChEBI" id="CHEBI:157765"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>5-methoxybenzimidazolylcob(I)amide</name>
            <dbReference type="ChEBI" id="CHEBI:157765"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000376-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000376-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="447" mass="48644" checksum="C57BD1A0515E6728" modified="2010-08-10" version="1">MALTGLDIYKKLPQTNCGECGVPTCLAFAMKLASGGASLDSCPHVSQEAKDALSEASAPPMREVTIGQGDNALKIGGEQVLFRHEKTFFNPCGFALVIDDSMEAAEVDSRLESLKKMRFERVGYELKTDLAALKCSSGDKSSFAGLVEKVKGSCDLPLVLMSDDPDVMSAALDVCGTGKPLMASATPENCDAMAELAKKHQCPLVVRAGSVEELSGLTDKISKAGVQDLVLDSGSRDLSKTLENLVMMRRSALKKKFRPLGYPTITFPCQETQDEMLEAIHASVYVMKYGGIMVMNNLEPWSALPLFVLRQNIYTDPQRPMQVKEGFYDFASPDESSPVLVTTNFSLTYFIVSSEIESSKRPAHLGIVDSEGLSTLTAWAAGKFTAEKIAAFIKKSGIEDKVKHRKVVIPGYVAQIKGELEEELEGWEVMVGPREASEIPGFLKSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMB2</accession>
    <name>D6SMB2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868952.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3259"/>
    <dbReference type="EnsemblBacteria" id="EFI35823">
        <property type="protein sequence ID" value="EFI35823"/>
        <property type="gene ID" value="Dthio_PD3259"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="169" mass="19163" checksum="E18ACEE24258D794" modified="2010-08-10" version="1">MDVIEAIMNRRSIRKYKDKPVTDEQIKTILEAAMVAPSAGNAQPWHFIICRDKETQSKVKEINPYAAMADKAPLGILVCADLSLEKFPGYWVQDCSAATQNILLAAHSLGLGSVWTGIHPIKEREEGFQKLFNLPDQVIPLAYVVIGYPDQDHKTPSRYKPERIHYDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMG3</accession>
    <name>D6SMG3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase (Ubiquinone) 24 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869003.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3313"/>
    <dbReference type="EnsemblBacteria" id="EFI35874">
        <property type="protein sequence ID" value="EFI35874"/>
        <property type="gene ID" value="Dthio_PD3313"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="173" mass="19555" checksum="F4B343D8F4078A8D" modified="2010-08-10" version="1">MQEYITHTDSSDYFRPMHSDITPDMWQDIDRIIQESLDIPGAVTQVLRRCQDLVGYLPVELLDYIARGMNIPASEVFGVASFYSLFSLKPRGRNIIRVCTGTACHVKGADLVMRRLKQTYHLDDGSTTPDRRFTLESVRCMGACGLAPAMTINQTAHGHITPDQALKLLQEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMJ1</accession>
    <name>D6SMJ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3341"/>
    <dbReference type="EnsemblBacteria" id="EFI35902">
        <property type="protein sequence ID" value="EFI35902"/>
        <property type="gene ID" value="Dthio_PD3341"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007434">
        <property type="entry name" value="FemAB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04339">
        <property type="entry name" value="FemAB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="388" mass="45674" checksum="A7C9F1BBBDD5CA6A" modified="2010-08-10" version="1">MHDLMDTEQGFYFKWHDSIQQIPGTDWDTLTRDLDTPFLDWEWLHLLEESGSVSPEAGWQPCHLGLYSSHRLIAAAPLYIKYHSQGEFVFDQQIARLAMRLNRAYYPKLVGMSPFTPLKAYRFLVHPGQDQDALVRLMQEEIENFCLRHNLSGAHYHFVDHPWMKLLNTKNFASWLHPGFVWENHGYRDFDAFLAGFKSSRRKNIKKERSKLATQGIRIQALTGDDIQPEHLQSMYNFYLHTNQKYFPWSCKYLTREFFLGLTRDLKKQVLLLAALGEEHQEPLGMSMLLFSKDRLFGRYWGGMDNLPFLHFSLCYYEPINWAIQQGIQTFDPGMGGEHKLPRGFRLVPNYSLHRIFDPQLQHILSTCLQEANMHLQQNMDELNRTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMS8</accession>
    <name>D6SMS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3431"/>
    <dbReference type="EnsemblBacteria" id="EFI35989">
        <property type="protein sequence ID" value="EFI35989"/>
        <property type="gene ID" value="Dthio_PD3431"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="727074at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="PTHR10606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PF2K" evidence="3">
        <location>
            <begin position="27"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="432" mass="50544" checksum="E798445B2E00D124" modified="2010-08-10" version="1">MPFNLKDQAFEHLKGTETERKGLFVLMNNGYLNKLYIAMVGLPARGKSTVAAKLKEGLKKENIKVRIFNNGDLRRKLLSENSSRPDFYNPENKTNAEQREQIALTNIKNASRYLQGDGQVAILDATNVSLKRRRTIQNMLTDHPVLFVECINNDDEILKASITKKTEQPEFSRMDFQEAFESFKKRIQYYEHIAQPLQEERNYYVLDSLNNQILGERMTDNIFCNVQIRDLLVSDWVKNLFLVRHGESYFNLENRIGGDSELTPNGWAQAQALAAHFKQTNIPNIYTSTKKRTVQTARPISEMQKNAQVMQLKEFNEINAGTCEYMSYDEIRREKPEVFYSRTKDKYNYIYPEGEGYVTLKHRVDRGLKKAIYLSGNATYIMIIGHQAVNRMILAHFLYRRKEDVPYIYTPQDRYFHIVSTQSKKLFELKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMU3</accession>
    <name>D6SMU3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869132.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3446"/>
    <dbReference type="EnsemblBacteria" id="EFI36004">
        <property type="protein sequence ID" value="EFI36004"/>
        <property type="gene ID" value="Dthio_PD3446"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="325071at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013663">
        <property type="entry name" value="Helicase_SWF/SNF/SWI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08455">
        <property type="entry name" value="SNF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="618"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="906"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1068" mass="123983" checksum="C202054AA05B9963" modified="2010-08-10" version="1">MLSPEEQKAQDIIQKFIHDNIPEYILENAQELYSENGIHKINVNQRDQYLDLEGRIQGEDFQVYNSEIGLNLDSETINFHCNCPESFTGICKHIGATALKFLAGLREETGEDTPVTRTEWRHTFRIYFATELEPEPGQHYLVYRFFPEPGRLQVEFYRARQNKNGLSSVLNPVTLEQIIRNPNWCEISPQLPDVVTQIGYSLDYFGHRVEIPPGLLTWFFWSIRNEYYLFWEDTEQPVRVETTSMRLQLSPRLTDEGLGFDIMLGREGKLPFSISGEKAFFYGQLPLWVCWKNSFYPVQTGLNPALVQELVSEQPVIPHSEISEFLDRVWTRIHTSDLYGHEEFLERMSPIFVPAVFNPKLYLDEEGSLLTLQIQNVYETEHGEITLPGPNQDLQTGSYQFEGKSFLVRREQAKEEELLSNLQNIGFQSRNNNMWFLEPEEAITFLLDSYPRLVEQYRVYGEKNLTRYRVRLSPPNVVAKVDTSKDDKWFNLDIKVEYDDIRVPIEKIWKAWIQGKRYIQLKDGSYTSLPESWIKKLEHKLQTMGLDPQKAPKKKFQNHEVPVLENILDDIDNVQADSFWNELREKIHSFKEVRQIDPPQGLNAELRPYQQQGLSYLNFLYEYRFGGILADEMGLGKTIQTLAFLQKLKEQGKKGPSMIVVPTSVLTNWEREAQKFVPSMQRLLIYGSRRSGMFKKIKQSDLIITTYALLRRDLEELQEHEYNAIILDEAQNIKNPNTITARSVRKLQADFKLCLSGTPIENNLLELWSLFEFLMPGFLGSQHAFQKGFVKPIKDGDEESLAYLRNRVKPFIMRRTKIEVAQELPPKVENVYYSALMDDQLDLYSALAKKLKEQVLQRVDEKGISASQMSILDALLKLRQICCHPRLLRLNMPGLNNNIPSGKFEAFKDLTTNIIEDGHKVLVFSQFVQMLHIIRSWLNMNEIPHAYLDGSSKDRLEQVDLFNNNPDIPVFLISLKAGGTGLNLTAADYVIHYDPWWNPAVENQATDRTHRIGQTKQVFSYKMICENTVEEKILKLQEQKKGVAEAVIPGQNAWKSLTRDDLEMLFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMY6</accession>
    <name>D6SMY6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869175.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3490"/>
    <dbReference type="EnsemblBacteria" id="EFI36047">
        <property type="protein sequence ID" value="EFI36047"/>
        <property type="gene ID" value="Dthio_PD3490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="7635" checksum="B3BE23E7C3264EE5" modified="2010-08-10" version="1">MDKEKIILPWPEARPKGYHSSTHFFPALMKKKVSAGWLMQSAASGLPCEIPKDSAADFTGAADCLSCLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN74</accession>
    <name>D6SN74_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869528.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1551"/>
    <dbReference type="EnsemblBacteria" id="EFI34200">
        <property type="protein sequence ID" value="EFI34200"/>
        <property type="gene ID" value="Dthio_PD1551"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="299750at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="3984" mass="432018" checksum="1819B6AC69D24962" modified="2010-08-10" version="1">MATHEFFSDLFEFPEGVTHVRLWTGEMEGENLLGGSAVESDMSLGRGWFNVNDLDKISLSDIPSGHNKLYSQFHFEDGTTEEWQSQTIGNTPASDDSADSYTFEDLIDYSTDVTHVRLWTGEMNGNDVIDGSVVESTSGLGRGWFSVEDLKSLDLSSIAANHNSLYVQAHYDDGTTGDWSNHAVDFKQFNGDSPASDDFPTVDIQAEEQSDKVSVLDSIDRNTTLDQMFTYTQDVEWFKITIGDNELNNGKWFRADTLSSYTYTLNQARDGVPISYQYYDGQDISEWYSHDVEPVLPTQKFTLTEAIGEKEDVYVDVDPITETHIYWGYSLCSDCDDPKGISLTRLFQSLGGEDGDGILGALDGIFGFGEPMKIESFQPILDQIKAITEAGVLDDLQGAGAIGEENDNVQVVEGDSNIIFFEDDGTVVVEQVQGKEGDYTGNYEIVLNIDSADVVDGEVTLKLEAFNFLHNLLFDEDGYSRLFEKEVTYMPQVKLSELYPDAEITKYGEDADQDIMVDLHEVKVEGGKYFKPIVLTPDTNNGGTIEEGNTSDNDTLIEAGRLDLLHQAYIDGGGGYNTLEVDAKGHFAQPLQMMNIQHVSIENLPNIYTYDDVDADNIGDDFNYGRDGDGDFPDPGYGLSDNQNSILDLARALDLEKLTITEGGYQGLFDDENLNAGNLTVSGIRNAAELHLQGGFNNHLNLHYGRDNTGDGIDIVLHNVDFNPSGDAAEEGPDGALGFNIAHNANTFNFDSQGGDNHLGNISSLYNATLTTINVTGSAHLHISGDLNNIFRDDRPATFNASENEGGVDINFDGQERIVFTGSQADDEFTAENTREVIVNNAAGSNRYIVESNADAYEDGHSKLLIDITDETGNNKYDLTTTEGGHVLVSAEGDGSNELELYVNTPEENGSEAEKVDIYLAGDHNDVEIEGDIELADIVLGGDYGVVDIDGEVETLNVTLEGGNGQVYAEEVTEAKVEAFGGDNTVDLYGEDISVSLAGDGNNVFLNGSYESDGLGYGEFTNGALINIEFTEDGSNDVILGHPDDDREGGDAGVTALEGSSITGDDVALTVLEASDLRAAELDGINSVVMNDELTLTVEQFLEIGPEGFEAYREVFGAEQTLNLIVKDDTDLSGVDLSSLRDFNFHVGGEVAQASGIELNFLITKGAELTLTAEQLHYHVDEIESEKDTVGNDLLGSVKIVGAGPTFDPYTGFESDYDFGGSLSSDFDGSGNVTVIRDGDFERPGVSDTEDTLTLVSDEVSPISEDFTTLAQTLEIVGDQDMVFDDGAVVNMTTNAKDGFTLDFSGLQGNMEGLTLAEIGGTRTIKEIIGNSSDTRIDLELDGNVGDEDDPLVTSGVETYVVTDMDGKDRFVFTSEVTRDVETLGLSGNYEQYLVYHNVERGVDFLMEVDLDKYDGYSVGTLIGNYARSGADAVVNVELAEGVDLPQGEVMKVAGIMLNNGDNATVNVTGGDTVIEGLVGLNEEIFEDFREFHPDNLAGLTDVTFTSDNDVTLNVYHFNSMLESLDASDVDGDMTLVIGKEFRGVELGAVNFSETDLTGIDKVVLEEGTELTLTADQIVDITVDDISGEGKLNVTGLSDQEIDLSAIDVDNIGTVTIADGDVITLNENTNLGRPEEVEIEAKESDTILEMTQEQFLQLKYAAEDEGYDMARVHSDNAERDPSTGRYYTSTLVLTSLSNDFGGDPLDLGGVETDKLVMQLDNFQGEEGTKIINFGDGMDADDRPDVRFELSGDNDITNVEEDNLYAPQNLEIHFASDGEFAVTADQLQAFTEAGAEFSTAEDVSATINIADYEDQVFYADLSEIYESGIVMDAPGVWVWDSTEEVEDGEEISVLNIFSDGLDYTEVAEIDPTHLNGAEDYDKLVITGDQDLSIVEPINFLGEDFTLDFSGLESKLGWDADDDRGASYVTISNFENVAEVIGNEEYTRLNVELKGDVAEAGMENGLKSSGVHTYVMTDLSEEDNDGVSHNFYVCDLTKDLQTLGLQKNGGDTIHFQQVNWGVNFLMEGDGAENWNDLPKADGNPNQSNIGTLKADFFHEGAPAVVNINNQGQELGVTSEDEARALVVDGIEMNNAKSLDVNVEDGNAQIGSIFGVNEGVDIGEDDFAGLEDVTFSSDYDVTLDVHHYNSVLKSIDASDVDGYMTLVVQDADEAPGVDFSSTELTDIDAIVMEDGSDLTLTMDQIQAIEPQNITVQDEDDDEATLNVADFSDEQVDFSDMGVGEGVNIGTVTILEGYVGALDTDTVLTGVDKLVIPEDSELTISGQQLLELFKSGAAVEGDGALNIEGITQDQLDEAVDALDNDAELNIGDDITPGTITFDGDVSIPEDLGLSNLDVGDGSFTIVLSDGQTIGIENFDLADGLKIEGEEGATDKPLVWFKFIEQPDFEDTIDVGHYHLVDLKIRDELINNFSDSQAIEDLLENLENASILNIESVPPEEIPYARFRDVVVEPDAVPDGLTFSAGKYDGADGENVEEVREVVLTLQADGEDAATVNGPVVINDGVHRDQYTMLTINTEDISGAQALTGDPVVIAGNIETDGDKSGEEGDLLDITINAVDVDLEIEGQIVFSAENVDEATATLTLTGDANVDIKGLDTTDSAIDHLVIDTDDYTGTLNIPGGSDSLEMANTETLTFTGGEEEASIVLDTVDGGDDLEEIDASDYAGDLDLGEVKNINSEDFTFTAGTGQTEMELNGNELDGVWSFDFSDAAENSVFEIGANAWIAGSVLNIDLGDETVLRISEDTDWTVLNRLDIDQNQEIDLNGAELTLTAAQADGLNIGGSGTVNIQDLGEAETDLSGIADNIAGEATLDSDVVELHEDTDLGDFTVVLGRLDDFSQVIGFATEEQADGREVIVLKDNGDPVGDSNAIAWLFDTITDKPIDASGYSGDIKRLFVRDELVTDDPEVEGYWEGLNRGIEIINIQYTGDLEETLDVVRPVDRIFEVAGFTQLESGLDLLEGEDKQFYKNVDVQMGGSVEIEDLTLNSFIDPTEVRNPEEAVFETLTITSGKFDTGRVFDRFDNVFAPEDWAAGGFDDDDNPLGEDGNPLVLPGANTIGNISSGDGLNLLNVVLETTPIAKDEDGDVVDPVPLYVGDITFDRAEDDDDNASLTISGSEDAEVFIDRLVLTDDSLTNEVSDDVYEVVFDIDGTGYLGKYDDEEEEIITDTVIEMDAAEEGATAILNTDMANVAYVKSIELGDNIEEYEIYNTDAHLHVIGGSAALTGDNLESLTIEGNVTIGSPDWDSVQTVNDDFYNVGADQAYGIDAGNLTEVTVGDAEESRLFFENINSEEFNLSGDGNVEVVLLDVELDADGEWTFQDTGEVRITGSTDLSNGGDLTIEGDLLVDGEVDLTDLDSFEGSQDKLTINYASVLTADREILNQFSEYETSGPVEDEDVEEGKLRQVDDEITARDGIGHYILDTDEVDDDITFDFDGQNPNLTREGDDDHVVTLTGLSGFLSETTWTGFEEDNDVLQVSSDIILTEVNEGDDFGGITILDIPEGETRVTMTADQHDELDEVTGEGELTIEIVGGVDTEGLEGVHRYILDKGEENVFTVADYNQTVEAGNEGDILNANTGADTFVLGDGEDTVVYDDAEQSLVVESLGEVERVSPGADQQAQITQLTFLTDPEVDWDEQNDWEYTFNIIAGEDSGVNDVTVPVTLVDPSDRAAVVAQIRDELNNDGDFSADYEAETTAAQGQLRIIGREEGEDQTFTVDLEIKNDLNEEQDNEDYIQNPGEEGEDVGEEIQSAADEEGGSIVISIDDDAAEKINGLNFQINEDDGEGFQRVDDYLPGFFENVDDVEKLYLELIADHNWDDGVSPFDQTIDFEDAYDEDEGELTLTLEDVGHSIEMADGYDAPFAFYYNDKVKGFEEGDSLDFSDLGLTEDNWLDEAIEIGDVESPYEAAHIAATELEDDDDKMFGFFELEGDTYIYGNLGDEDTVSSDDLMVKLVGVDGDDLDVENGSLVWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN77</accession>
    <name>D6SN77_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869531.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1554"/>
    <dbReference type="EnsemblBacteria" id="EFI34203">
        <property type="protein sequence ID" value="EFI34203"/>
        <property type="gene ID" value="Dthio_PD1554"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="697026at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030916">
        <property type="entry name" value="ELWxxDGT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04534">
        <property type="entry name" value="ELWxxDGT_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1826" mass="198778" checksum="A4C540782FFFDA0F" modified="2010-08-10" version="1">MSNSTQQNSVFQVSSANNQSPRFVFVGNDGQDGHALWLTDGTEAGTELVKASDQDSYTRIFSMELLTDGQVLFDAGTRGLWITNGTQDGTRPVFDPGITYDSGPLEPADLTQVTDGIVVFSARSRGEPYLVRELWVSDGTPGGTRLLKEINPTKDNEGNALGSRPLHFHRLGDQVLFSAIDEGDMAANRSLWATDGTQGGTIRLLDSDTFYMFSPRSIGTDKLLFQCLSTDEDGTSYWVTDGTIAGTVPLGDFGLQPGSRFHTYAEPDGRVSFWSNGQWNLTDGTNAGTRVMGSAPGLTDEGPEPITFFRGGGEGPYPSQIFYSHAVTDHLTLYSARTQEISAEGNFIYGGNGLWLTDGTESGTDLVRLFDGRPRDFFTLDDGSTLFAVEGGSDGGLWVTDTTTNVMQKLAEGVFDLSGTHFRPTHLGDNRILFRTGEHLWVTDGTIAGTEQLRDDSRGVRLSLPDGTVLFTGTDSSLWSTDGTGDGTYQLIEEYEPFQIRDLLSYLEENVHSVELGGGRYIVPYATPEVGMTTEPFLMDTGTGSFNLISEINPDGWGTRALFMRLDSSAIDNILPPLRFSLEGMVSTLALDEFFFDPLGEELDYQVGGLPEGMQYDADSRAVTTLEGIAPGEHTITVTAANPQGDSVTDEFDWTVVDTGQLLIDSTGDWLIPQEDGPIYSELGSTILVGHKDGDGWLLRLEEGRVAIEDGTLEIMDGQFWSETLNLDSPLMEGSFNVDMQSLEVSEFEDTNSPDSYRLVAQMIGLEFADLTIRPDELLFDTDLRFGEGFVTLDTDGTPLLLSTLPEGPMFSPRMAGVGTGRWFKDDDALNLSVPGGSLSLELSNFGVYYDAVEDTFDFSGKAELSWGGKVQDQFRVIGVDTARSMELDLAGDAVDDDAGLFTRGENFLRFSPGSEEEPWSWDVSGSISYSAKSVPGYVETTRPLISELGLELDTTESSFGGNIKGQAPFLASGVELEIELGAFWDPIELEKLKLGLDGLNAPLGSTPFFIQGGELGVDGLSGRDEESALSYQGRIKTTLGPDTTVTPSPLHGSLGGEFTTGDIGLDFKIDSKVGYFVPGVVQSFTDPLVRWFGVNPARINDFTLLEATGDIEYDLAYGDIQTSLGIELLEGVVSAQAQLELYTRGDISHVDASMVATLHMPEAVPLIGGRGTSGTAMLEYVGDGNGQNSSVAAWRTIDLPFGLKTGVGLRADFAGNVELLGQRQIEEIGSWELHEDLSVVVLTARWEEAATDRTLELITPDETVLGEAEWSDHEDIVLVQELSDDYGRAVALQNPARGTWDLRLSDESGLGEVTYDASEMFQGPSTEILSVEVDAGSDQVHIVFDTELQDADSGVVQLYASLSPETVDELGRRITTDAIEVVQGQQEYVWDYREMAPGTYYVNAVTTAEGLAPDHAFSDEPVEVVGSADLVLSVEQEKGPIEETFLLTFTVSNEGERDSGSGILSIDVPESLVGYQPDSEFQSFTDKVTEVNFENIAAGDSADFEFLIPADFEDPAVPLQAQVQAAVYDADPSRNQILYGLFPASEEEQDDDDDPLLQDFEFHTQVDIAVGSPFSELFTDVQAMYTHYQVWTGRIEDGIVLDGNSSGWIPAEHLDDYSVGYENLEHNTLYVQGWKQGAPPGGWHSNAWRDGDYFDFPGPPEIEFNVDSDISVGTSFSELFTDQDDTTTWYQLWTGELDQEGVVQGSVVDTEAGGGWVRAEDLNGLQVTGDQAGHNTIYVQAYSPELGMRDWQSNDWQNQEYFGFPEPWGYELAAQHKLIVHLDDGSKGNVADLPVAVADYVNSDDSGSLALQGVQDEQDSGDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNF2</accession>
    <name>D6SNF2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869606.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1629"/>
    <dbReference type="EnsemblBacteria" id="EFI34278">
        <property type="protein sequence ID" value="EFI34278"/>
        <property type="gene ID" value="Dthio_PD1629"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1714881at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008309">
        <property type="entry name" value="UCP025560"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07027">
        <property type="entry name" value="DUF1318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088120" evidence="1">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="134" mass="15460" checksum="A2E2F9D15D5B7347" modified="2010-08-10" version="1">MQNKIWTVLLICLLSFMLGSSAAWAQNRSKDEVVQSMKDRHSSLVQAKDQGLVGEAWNGMVALVDQGAPSRVQDLVDSENYDRRELYQIIAADTDTSVQEVALQNRIRMYRLADDNHYVQDQNRNWVRKKDFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNF9</accession>
    <name>D6SNF9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869613.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1636"/>
    <dbReference type="EnsemblBacteria" id="EFI34285">
        <property type="protein sequence ID" value="EFI34285"/>
        <property type="gene ID" value="Dthio_PD1636"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1356187at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="306"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="469" mass="53950" checksum="94F148E8B15E8E47" modified="2010-08-10" version="1">MSEEISIKEITNRCLEESRAFKVQKRLLEKIDDYADYAFSPIQSSALNVFFDLSQEYESFHDLLAVCVLVPKVFFNLECNLFLLRENRVEMVATCKGNCPEVTEGRMDNLQICPEPQVIKDCLYLPIKANRDMLDQLPFSLPQGLIGMLEVYPARKINEHGRFFFQKYANRVGFQLHMRMISWKNEEHLQFINSLVKDIGHNVIVPNMFFKIFYRRLEAQINALGNLKDDMAAIARAAGDDPDKGLVDSRELLPRLEYIHNGLREQYSEILNHYEQTSLFLETLLRRSHFEQGKYVLEKKVCNFKSQIIDPQVERFTPQFREKGIDIALAGVPDQEIEVVVDKGLISQVYANLFSNAVKYTREVTDFSGHKAKFISYGWEYKPDYFGPEKPGIKLNVFSSGPHLSPEEQASLFREGFRAGNVGKEQGTGHGLFFIKEIVEMHGGEVGYEPTPLGNNFFFILPLTESADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNI4</accession>
    <name>D6SNI4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formate dehydrogenase, beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869638.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1661"/>
    <dbReference type="EnsemblBacteria" id="EFI34310">
        <property type="protein sequence ID" value="EFI34310"/>
        <property type="gene ID" value="Dthio_PD1661"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015944">
        <property type="term" value="P:formate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014603">
        <property type="entry name" value="Formate_DH_Fe-S_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036298">
        <property type="entry name" value="FDH_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="240" mass="27609" checksum="EBCA4BB7B3870825" modified="2010-08-10" version="1">MGKGFFIDLTKCTACRGCQVACKQWHKLPAEDTHNWGSYQNPEDLSFITYKLVRFEELVENGQVKDWLFFPDQCRHCISPPCKMVGDMDDEQAILQEYETGTVMFTGRTKNLFPDEIRDSCPYDIPREDEESGVISKCDMCFDRVINGMLPACVLACPTGSMHFGDLEDMKAMAEERLEEVKQIYPDAVLGDPNSVRVIYLFHRKPSDFFHSAVASLHGPKRFTRKEAFARLFRNNRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNK8</accession>
    <name>D6SNK8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formylmethanofuran dehydrogenase subunit E region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869662.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1685"/>
    <dbReference type="EnsemblBacteria" id="EFI34334">
        <property type="protein sequence ID" value="EFI34334"/>
        <property type="gene ID" value="Dthio_PD1685"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1454794at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026328">
        <property type="entry name" value="FmdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003814">
        <property type="entry name" value="FmdEsu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02663">
        <property type="entry name" value="FmdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006578">
        <property type="entry name" value="FwdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FmdE" evidence="5">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DksA C4-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="204" mass="23096" checksum="D9BFFAFDA0A048A2" modified="2010-08-10" version="1">MSCSLSSQQIEGVTSFHGHWCPGLAIGIRAGEWALQEMGRSGDEEIVAVVETDMCGVDAIQYLTGCTFGKGNLIYRDLGKNAFSFYRRSDGRAARLVTRPEVYGDIRRTLSRLHAKMQEHGLTPEEEKELGEARSMLSRRIMESPLEEVFEIKTPEHKAPRKARILNSQTCETCGEQVMETRTRRLQERTLCIPCFERLENPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNT3</accession>
    <name>D6SNT3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869732.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1767"/>
    <dbReference type="EnsemblBacteria" id="EFI34409">
        <property type="protein sequence ID" value="EFI34409"/>
        <property type="gene ID" value="Dthio_PD1767"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10945" checksum="9EE2DA23C8D868FA" modified="2010-08-10" version="1">MSDRNIGQEILEGIKEVKRFKKGDVELKAWHLNEPSPAKTIRKKLKLSQSAFASLMGVSPRTIQDWEQGRRRPQGPAKSLLRIAEQHPEIFIEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP74</accession>
    <name>D6SP74_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">DNA gyrase subunit B</fullName>
            <ecNumber evidence="4 12">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gyrB</name>
        <name evidence="14" type="ORF">Dthio_PD1922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4 12"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869870.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1922"/>
    <dbReference type="EnsemblBacteria" id="EFI34550">
        <property type="protein sequence ID" value="EFI34550"/>
        <property type="gene ID" value="Dthio_PD1922"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="423"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="800" mass="90770" checksum="A34DA8D9C8A8E45F" modified="2010-08-10" version="1">MDNKDRQENSGEYTAQSIQVLEGLTAVRKRPAMYIGSTDVRGLQHLVYEVLDNSIDEAMAGYCDNVRITVHMDNSVTISDNGRGIPVDWHEKENRPALEVVMTVLHAGGKFDNASYKVSGGLHGVGVSVVNALSEYLEVTVRREGEKYFQKFERGIPVTKLRHEGPSSSRGTTIKFRPDEEIFSTLDFDYDTLSKRFEELAYLNSGLRIEFQDERYQKSDVFQFDGGLLSFIKNVNKDSGLHKVIYASGEVHNVSMELTLQYKTGYKEHIYSFANNIRTVEGGTHLNGLRSALTRAINTYIQHAQDLPRKLKQKLTGDDVREGLTSIISVKVPDPQFEGQTKTKLGNSEISGYVSGIAYEKITTFLNENPKDARIIVEKVVDAARAREAARKAKELVRRKGALSDYSLPGKLADCQSKNPSESEIFIVEGDSAGGSAKQGRNPKHQAILPLRGKILNVEKTRFEKILENNEIKALITAMGAGIGDKELDLSKLRYHKIVIMTDADVDGAHIRTLLLTFFFRQFSQLIENGYLYIAQPPLYRVHKGNFEQFISDEKTMHDFLLNRVYDEISIKTENGLEYTKDEMVELIKNLISLKDSFEDAGNMGIKEELFQSLLEYGPRLHPVHFVYEDSSEFISFMSGRGFETTLEKEESEIEKRYFLVFTDRNEHSTRIGIEFFNSGLYKKAHQVQQQILHNNPGLGFEILSQKDTIQVKGIFPLLDKVFELAHKGINIQRYKGLGEMNPEQLWSTTMDPDKRTMLQVNVEDAELADDLFSRLMGDKVEPRREFIEKNALEVADLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP88</accession>
    <name>D6SP88_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ORF">Dthio_PD1936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869884.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1936"/>
    <dbReference type="EnsemblBacteria" id="EFI34564">
        <property type="protein sequence ID" value="EFI34564"/>
        <property type="gene ID" value="Dthio_PD1936"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="10"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="190"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="192"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="400" mass="43823" checksum="F9F1DA6923F431CA" modified="2010-08-10" version="1">MIFDQYQGQRVHLGITGSVAAYRTLDLVRLLQKSSLSVSATITSSGCAFIGPLTLSALGADPVYTPDYSPVEQPFAHLSSQFSPHVFMVAPATANILAKASSGIADDLLSTQILSYPGRVLFAPAMNPNMWNNAATRHNIRQLRDFGHEIIEPDSGKVACGEQGQGRFPDIASLYYICLRELTSKDMVSTKVLITAGPTHEYFDLVRYWSNPSSGRMGLAIALALWLRGAEIHFVHGPMQPLLPLPGFHIYPVTTARDMYDKCSALWPDCTLGVFSAAVADFAPEKATDLKFKKQGRSALQVKMNPTLDILAEMSASRARDQKIVGFAAEAENLEANASAKLSTKSLDMIVANQVTSDCTPFGSDENQVLIMDKTGRMEYLPKLSKQKIAWRMADWILEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPD5</accession>
    <name>D6SPD5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869931.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1983"/>
    <dbReference type="EnsemblBacteria" id="EFI34611">
        <property type="protein sequence ID" value="EFI34611"/>
        <property type="gene ID" value="Dthio_PD1983"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="202" mass="22531" checksum="95901D8DD24ADB23" modified="2010-08-10" version="1">MQVHEAIEKRRSIRKFADDPVSRDEIMKLLEAARLAPSAMNAQPWRFKIVDGREDIQWLSGSPTRGQKWVAGAGAVLICCADITRFLEDARAAVRFLRDSAVLPPEMQAGVEDYVEKAQNAPTEVLRGAVGMNCSIALTHIMLRATEMDLGTCWIGMYDEEALRQRFNLPQQAAVMALLAVGRPAESPEPRPRKAMEEIILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPG6</accession>
    <name>D6SPG6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GAF sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2014"/>
    <dbReference type="EnsemblBacteria" id="EFI34642">
        <property type="protein sequence ID" value="EFI34642"/>
        <property type="gene ID" value="Dthio_PD2014"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="15"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="181"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="37382" checksum="B26BC5A9B3712C90" modified="2010-08-10" version="1">MPECKAQNGKYPPMNNDKWLSRILGLVCSVFDGYSTVLFLRDPGRDICRIAASFSLGDSISTGYEIKTGTGLVGWIAKNDKPLLINNFDRDEGCLGYYPRESESKIKAFMGCPLPQEAGVLCVDSKKTYSFSDKDQKILYQFAQLVQDIRQGLMQADHSLKSREYYRYLALIQELRQRVPKWRSFLQQLLELLSQSTGFSHCFMAARDERGEGYFIEGLQQEILPRVNLKEHKFNIDSGLLGWAFKHGSPVFSGLHEGPAGLPLFGKEVPAKQFKSVICLPLVVHRKTRGLLVLADTGALPIDEELKGFVYMVGDYLGLFLENLYLKSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPH7</accession>
    <name>D6SPH7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869973.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2025"/>
    <dbReference type="EnsemblBacteria" id="EFI34653">
        <property type="protein sequence ID" value="EFI34653"/>
        <property type="gene ID" value="Dthio_PD2025"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1580474at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="30002" checksum="692FCC4D0A331DE1" modified="2010-08-10" version="1">MTHQQSTAEVRSPQINGVFSSTSKITVGYGHTKKKTTQYILIYATEREDGNINIQTLNEKYVPTGASRVISKDNLMTNYLPEPELYMNKVYPVIRELSKTVARGERHLRNSENYSAEMEFKKALRVDEENIRATFGLGLSYLRRGETDNGKTVFKRLVSLKNAFEPEHKHMFNEFGIQLRKNKMFVQAIKYYSRAMQYSQRDENLYFNMARTYYEYGKTSMAVKFVQKALEINPQMSQALEFKSYIVKKMPTYHLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPL6</accession>
    <name>D6SPL6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870012.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2064"/>
    <dbReference type="EnsemblBacteria" id="EFI34692">
        <property type="protein sequence ID" value="EFI34692"/>
        <property type="gene ID" value="Dthio_PD2064"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8088" checksum="960EEB298D5F31D2" modified="2010-08-10" version="1">MPLHEFVCVDCGQEFEELILKEDETVTCPGCRGSNAQKLISACKFRTGGPVVQGSPSANAITSRSSGCGGCAGGNCSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPQ2</accession>
    <name>D6SPQ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870046.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2101"/>
    <dbReference type="EnsemblBacteria" id="EFI34728">
        <property type="protein sequence ID" value="EFI34728"/>
        <property type="gene ID" value="Dthio_PD2101"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496911at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010263">
        <property type="entry name" value="T6SS_TssK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35566">
        <property type="entry name" value="PTHR35566"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05936">
        <property type="entry name" value="T6SS_VasE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="414" mass="47320" checksum="CADB15A45F5C9995" modified="2010-08-10" version="1">MNQKLARVRWEMGQTLLPGHLEAQEESLATEVDARLRNMGLPYYGLVRLQWNETMLPEGVLAVQSLTAIMPSGLFLDIPGNTRAEPMNLNNIGSVQVPVYMHLVIPGHEQQASSPHLDEPGDIPRKQHFIIFSSDQAQSDALESLRLGLFYKDPQGTWQLSSGSIPPFLQVGRCPFLQQELKELEQLLEVFQQKLSQEIAASYLSGDSMFSARECLKSSIRTGRMLANISAQYQPHPFYLYEALKEFLTDVALYRDMQPEHVLAPYDHEALGKCFQNILEPLKEHMRQFQRRATFLPFEFKDGLHQVDLPGQVKEAKEFYLLVQKSHVHAAVSLQNLKLGGRSRLSTIHRLALQGIPLKKIERPPFQHKFGPEVDFYQLQPGEEWDQALRDLSLAFYDMPAFSGVRFFVYWRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPV1</accession>
    <name>D6SPV1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2153"/>
    <dbReference type="EnsemblBacteria" id="EFI34777">
        <property type="protein sequence ID" value="EFI34777"/>
        <property type="gene ID" value="Dthio_PD2153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="32" mass="3638" checksum="74BBB3D2A698AABC" modified="2010-08-10" version="1">MNGIVMVLSKVARDPSAQKIAIEIIRRMLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPX6</accession>
    <name>D6SPX6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2183"/>
    <dbReference type="EnsemblBacteria" id="EFI34802">
        <property type="protein sequence ID" value="EFI34802"/>
        <property type="gene ID" value="Dthio_PD2183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="395" mass="44060" checksum="7BC83012FF8D245A" modified="2010-08-10" version="1">MKNIFFVFKIVLFVFIFSTYFVFAMTEDRGAETDEHIDDITTVEELIEYGEVPPGFDKELEFTTQEEFEFLVENGLNGRNTEDITLDNGYTIKEGKFTMSWGEKALLAPGAIVDENGNEIGGGEMDISEIMDGNIPAANELNFESSEGDSSSGQGIEGFSMDGPDYTIDYADYWETDSHKIVEGHGIQKKGGNIYVDEGHAIDSDDEFVNYADSYESSGDEFNIGEAKAVLLDGTLFTDVKDSYFKTKDGAITEASVTSSTDDNSFTFEGITVEMDENDTFYVELNKETGKFDLTFDSDQGRIKATYPNVGCVEISPGSRFEYVGDAFDNLALFVPSYGVVYELCIRTLENEDFDSDCNNCGVVDYKNKTAEFNGIYQYEKPSVFEDRLLEETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ17</accession>
    <name>D6SQ17_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ORF">Dthio_PD2234</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870157.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2234"/>
    <dbReference type="EnsemblBacteria" id="EFI34843">
        <property type="protein sequence ID" value="EFI34843"/>
        <property type="gene ID" value="Dthio_PD2234"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1419568at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="53"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="219"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="293" mass="33018" checksum="DE216CBFF15F58B6" modified="2010-08-10" version="1">MSSEQVLKLGIPKGSLEEATRRLFARAGWKIKPHHRNYFPEINDQEMQCSLCRAQEISRYVENGTMDAGLTGKDWIMENESDVVVVSDLVYSKVSNRPARWVLAVAGDSPYRRPEDLSGKKIATELRNFTHNYFHNAGIPVEVEFSWGATEAKVVEGLADAIVEVTETGSTIKAHGLRIIAELLQTNTQFIANKEAWEDPWKRNKIENINTLLHGALRADRLVGLKMNLPADRVEDVMALLPSMTAPTVAHLYNTDWLSVEIVVEEDRVRELVPRLQEKGAEAIIEYALNKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ47</accession>
    <name>D6SQ47_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/carnitine/betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870187.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2264"/>
    <dbReference type="EnsemblBacteria" id="EFI34873">
        <property type="protein sequence ID" value="EFI34873"/>
        <property type="gene ID" value="Dthio_PD2264"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1217683at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="556" mass="60900" checksum="947ED53A364832FA" modified="2010-08-10" version="1">MAFQKESGIFKGMNARLTVISTAIILAALVYGAFYTEILSDNLSAARDFLNPFLEWYYVILVAFLLFFMVWLGIGHYKDVRLGHDDERPEFSFVSWVAMLFAAGMGVGIIFWSVAQPVLQFHDNPFVEEGGTPEAAIAALRLTFFHWGLNGWAIFAFVGLVLAYFSFRRDLPLTIRSALYPILGERIRGVSGDVVDTLAVFGTVFGIVTTLGLGVQQLNSGLGAVFDLEATLFLQLVITACIMGIAAVTVVSGLNRGVRWMSELNLWLSVAAMAFLMLWGPTNHLIAMTVEAAGYYAQNLLVMNLYTHAALEDGWQAEWTVFYWGWWLAWAPFVGMFIARISRGRTFSEFIMGVLLVPTVVTMVWMGLFGGSALYQELFGSGGIIDAVEEDVAVALFAMLQGLDLGLVGIAASIGMLLLIATFLITSANAGTLVVNTILSGGDPEPPRIHRVFWAVVLALLTAILLAAGGLEVLQSAVIMGALPFSLVVVAMTAGLLRALEDEKCAHRRGKRTETPREPWADLDDAGIKPVRAVPEKIRDSCRTKGKKPEYWRSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ91</accession>
    <name>D6SQ91_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870231.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2308"/>
    <dbReference type="EnsemblBacteria" id="EFI34917">
        <property type="protein sequence ID" value="EFI34917"/>
        <property type="gene ID" value="Dthio_PD2308"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="164"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="30035" checksum="2C4C9A16976BF074" modified="2010-08-10" version="1">MSSRSAVDDLQEIIEKLLGPGGCPWDREQTPKSLCDYLVEETFELVEAIRCDNPDEVKEELGDVVFLLAFISRLYGGGSFLQQAMHQGARKMVRRHPHVFDEKEINSLQELTRNWEEIKKTEKNHTRGYILDSVPKSLPPLLLAYRINSKAAKIGFTWARDEDLEDKLAEEWQEWQEALESRDRDRMLEEFGDYLFTLVEYGRRHKIKANSALAETNAKFARRMHQMEDLALEKGWDISKLDMEHLEELWQKAKGHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQD7</accession>
    <name>D6SQD7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870277.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2355"/>
    <dbReference type="EnsemblBacteria" id="EFI34963">
        <property type="protein sequence ID" value="EFI34963"/>
        <property type="gene ID" value="Dthio_PD2355"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="315" mass="34106" checksum="94500B81F8BAEC63" modified="2010-08-10" version="1">MAKTFIMYDQICKTHLAGSGHPENPARLDAIVSALQNEDQNSELVWQSPEPAREEDLFGNHEAGYVDLVRDSVAAGRHSLGYPDTGISNGSWDAALTAAGGLINAVDLVMEGKAANAFCPVRPPGHHARPGMGMGFCLFNNVALAARHAMKKYGLDRILVIDWDVHHGNGTQEAFYQEQEVFFFSTHQEAWFPFTGERHETGSGKGRGTNMNFPFSAGAGRDEILPAFTGHLVPTMDEYKPQLVLVSAGFDAMQGDLLGRFNLTEDDFARLTEIAMEIAGKHASGRLVSTLEGGYNLDGLARACAAHVKTLMQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQQ4</accession>
    <name>D6SQQ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2474"/>
    <dbReference type="EnsemblBacteria" id="EFI35080">
        <property type="protein sequence ID" value="EFI35080"/>
        <property type="gene ID" value="Dthio_PD2474"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="323" mass="37487" checksum="463007383A6A944D" modified="2010-08-10" version="1">MSRPGFYFFFCPDAGLVKRQIHKTLEPYDPDSWEINTLWSDDPELDQKLWKALNMANMMGPSRVVVVRNCQVFKDAQWKALAPALKGFKSGIWPFFCLEGQWDKQKPKIPAVLENKKFFKIARERGWIWQFPGITRQNLPRYLEKRARETGLVFAPGVQEKLVNILPLNSLGVDQELEKLLLLANDQGKVEAEHLDIVEPRADLDIFAQMQSIQQGKNITLVWQKFFRDQQTGQEALFPFLGLLLHEARVLWHLAAGEEDRVFLYPRTKNEKKRLARQLGPRNIARLWDMILEAEAGVKSGTILQDQALEKLTADLYQLFRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQS7</accession>
    <name>D6SQS7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870417.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2497"/>
    <dbReference type="EnsemblBacteria" id="EFI35103">
        <property type="protein sequence ID" value="EFI35103"/>
        <property type="gene ID" value="Dthio_PD2497"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="172" mass="19386" checksum="5B6DFE897140B77B" modified="2010-08-10" version="1">MLTPKMQEALNQQVNAEMYSSYMYLSMSGWFEDKSLAGCARWMRMQAQEELMHAMKIYDFIHERGGRAQLRAIEEPPGNWDSALAVFENVLSHEKKVTGLINELVDLAIQEKDHASNIFLQWFVTEQVEEEASADAVLQKLKLTADAPGGLFAIDQELGQRTMACPCGQGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQT4</accession>
    <name>D6SQT4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chemotaxis protein methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870424.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2504"/>
    <dbReference type="EnsemblBacteria" id="EFI35110">
        <property type="protein sequence ID" value="EFI35110"/>
        <property type="gene ID" value="Dthio_PD2504"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="216"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000410-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="293" mass="34374" checksum="0F8D2869F90426DA" modified="2010-08-10" version="1">MNSPFSQSITFKKELKIDDQEFKQLRDFIYEKSGIYIGDNRKYLLENRLGNRLKAHNLKSFKEYAYFLRYDSQRNEELAKLFEVITTNETSFFRNPPQIKIFQDQILKDIIKAKKARGEKKLTIWSAGCSTGEEPYTLSIVLHEVLQHELGSWKPKIIANDLSNAVLSAARRGIYTQYALRTTPPEIIKRYFVEESEGKFRVQDRVKDLVQFGQINLSDRFQLKKVERSDVIFCRNVIIYFDDEMKKNVINSFYDNLLPGGYLFIGHSESLHNISRAFKPLHYPGSIVYLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQT6</accession>
    <name>D6SQT6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870426.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2506"/>
    <dbReference type="EnsemblBacteria" id="EFI35112">
        <property type="protein sequence ID" value="EFI35112"/>
        <property type="gene ID" value="Dthio_PD2506"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="28941" checksum="62F28589502DFDCD" modified="2010-08-10" version="1">MPGEVLAIANQKGGVGKTTTALNLGSSLAGLKKKVLVMDLDPHACASIHLAFYPEQVTHSALDIFKAYPDFEGTYNTCVYKNRQGLLFDFVPSSIQLSELDADLRDVSGKGLILKKWIDGLRNDYDVIIIDCPPQMGIILVNSLVAADLVIIPTQTDFLALHGFKLIFDTMRLLNKALKRPIKYKVLATMYDRRASACRRVLNTLHRKMGPERLFETVINTDTKFREASARGRVIHDYAPRSRGALEYYKLAREILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQV0</accession>
    <name>D6SQV0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870440.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2520"/>
    <dbReference type="EnsemblBacteria" id="EFI35126">
        <property type="protein sequence ID" value="EFI35126"/>
        <property type="gene ID" value="Dthio_PD2520"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="15"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="138"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="298"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="427" mass="47858" checksum="4097D5D51F450BF9" modified="2010-08-10" version="1">MRNISSSPAAAKEKTILIVEDSKIFSHVLSNAVKKELGLEAVVCSCYQEARDYLEHGSQDLFAALLDLNLPDAPYGQVVDLVVGKGIASIVFTGEISDDLRDRMWSKHIVDYILKDNRHNVQQVVDIVKRLQLNTGIKVLVADDSSVSRKIIRDLLEVWNFTVLEAGDGREALDILNRQDRIGIVLADYNMPEMDGMELVKELRRTFSKTRLPIIGLSGAGGATTSAHFLKAGANDYMHKPFLAEELYCRVRHNLETTEYILTIRELAEKDFLTGLLNRRSFFNSGEKLFANALRGNLNLVVSMMDIDHFKKCNDKYGHDAGDEVICFVADRLKSSLRQSDLVARFGGEEFCVVGVNMHSENITEVFEKIRADIENSVIRSGEHEMRVTVSIGVCSTLKSSLEEMITCADDMLYKAKNQGRNQVCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR23</accession>
    <name>D6SR23_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870507.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0459"/>
    <dbReference type="EnsemblBacteria" id="EFI33139">
        <property type="protein sequence ID" value="EFI33139"/>
        <property type="gene ID" value="Dthio_PD0459"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="35463" checksum="E1E4244F3BF1D9C8" modified="2010-08-10" version="1">MPRIARFIRSDQATVYHVISRTALSGLPIKDTDKDYLLGLIKRLSRLYFVDVLGFAVMGNHFHLVARMHPEDEISNSDIIKRWQKYYGDEAQMPTDRMAEVKKRLCSLGAYVKDIKQNFTRYYNKKHRRKGFFWGGRFKSMIVQEGSTLVNLLAYVDLNPIRAGIVKKPENYRWSSLGYHTQTGNKDGLLDIDFGLKEWNELDPKEIVRKYRQFVYETGAVDAGKGKTIEKKVVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDERKFTPVGGVEGLYSMKRLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR46</accession>
    <name>D6SR46_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0090</name>
        <name evidence="8" type="ORF">Dthio_PD0485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870522.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0090"/>
    <dbReference type="EnsemblBacteria" id="EFI32792">
        <property type="protein sequence ID" value="EFI32792"/>
        <property type="gene ID" value="Dthio_PD0090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33162">
        <property type="protein sequence ID" value="EFI33162"/>
        <property type="gene ID" value="Dthio_PD0485"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1335357at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="209"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="45846" checksum="F4B2E769EF5A3595" modified="2010-08-10" version="1">MLDRQIQDYLEWMNNAGYAPWTMAQHSQILNRLLDFVVLNSIPWERTFARDTLQAFKDHVQVKYAGFVLRGFMRYLHQNGIICLPPGALPEGRGRSKLQRAQLPRLYEEYLQFYTQTRQVGHVQIYRVRGTLSALNDYLQNQGMELKDLDVLHMDAFLAERNRKYAPETRIHERSGLRGFLRYLYLERQILKKDLSALIQGPPVYAQSRPPRFLTLEQIKTLFQSIDKDRPGGLRSYAMIHLAYSLGLRPGEICRVTLDDILFRDKLIYLPDRKNSSPAKLPLPQGALRALAAYLAWDRPMDPGHRFLLCNTRTPYGPLTPLTVSQNISACFRRAGIKGSAYWLRHTYAQNLLQAEASIFEIKEMLGHDIIKTSKRYLHVHTRLMREVLFNEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRC4</accession>
    <name>D6SRC4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-6-naphtoate synthase</fullName>
            <ecNumber evidence="3">4.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnD</name>
        <name evidence="5" type="ORF">Dthio_PD0566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0566"/>
    <dbReference type="EnsemblBacteria" id="EFI33240">
        <property type="protein sequence ID" value="EFI33240"/>
        <property type="gene ID" value="Dthio_PD0566"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00996">
        <property type="entry name" value="MqnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="PTHR37167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="33583" checksum="AD86D1EC4D907D21" modified="2010-08-10" version="1">MPEIRTLNVAISPCPNDTFIFGAWILGLVPDLEGCRSRFAWRDVDLLNQWARKNYCSLVKVSAGQALDLQDEYFILSSGAAFGLSHGPKLVARRGLKTRPGVIAVPGLQTTACSLLKAALDYDFEALPMPFDQIVNCLEQGHVDAGLLIHETALIYQQYHLELLLDLGSWWGEEAGDLPLPLGCIIMRKDLGQALKDRVEEQIRCSLDTARQRQPELMPLISHLAQEMDTDVIDRHIRAYVNQYSRDMGRPGKEALQKLQQLKTSMSDPSDRSDTSDKSDKSDTSDKLRQNPLNPTHSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRD5</accession>
    <name>D6SRD5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aconitate hydratase A</fullName>
            <ecNumber evidence="3">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD0577</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870609.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0577"/>
    <dbReference type="EnsemblBacteria" id="EFI33251">
        <property type="protein sequence ID" value="EFI33251"/>
        <property type="gene ID" value="Dthio_PD0577"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="363064at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006250">
        <property type="entry name" value="Aconitase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01342">
        <property type="entry name" value="acon_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="13">
        <location>
            <begin position="520"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI33251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="642" mass="69142" checksum="A0E2B1D1FE9418D9" modified="2010-08-10" version="1">MHKNLTRKIIEEHLVAGSLTPGEEIQIKIDQTLTQDATGTMAYLQWEALDLPRVKTELSVSYVDHNTLQMGFKNPDDHRYLRTVAARYGIVFSPPGTGICHQLHLENFAVPGKTLIGSDSHTPTAGGVGSLAMGAGGLSVALAMAGEPYSLYMPRVVKVYLEGKLTGHAGAKDIILHILQRLSVKGGTGRVLEYTGPGVADLSVPERATITNMGAELGATTSIFPADETARRFLRSMQREGDFSELGPDPEASYDQELFVDLSSIEPMAARPHMPDLGTTVRELEGRKVDQVAIGSCTNSSYADLKITAKILAGRKVSEDTELLISPGSKQVLKMLAAEGLLEPLLDSGARILECACGPCIGMGGSPVSGGVSARTFNRNFEGRSGTQDAGVYLVSPVTAAHTALEGAFTSPEKWGEPQPRPSLPDNVPSIRDQFIFPEDADSREIYRGPNIVPLPQFEPLPQNLDLPVLIKCGDNISTDHILPGGAQVTALRSNIPAISEYIFSRLDEDFVPRAMQAGQGLILGGENYGQGSSREHAALAPRYLGVRVVLVKSFARIHRANLINFGILPLILTNPQDYDRLEQDQAIRVNTTDLVPGGECFLEAGAGDKIKAVNDLTPAELEIIKYGGLLNLVRERKKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRD6</accession>
    <name>D6SRD6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870610.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0578"/>
    <dbReference type="EnsemblBacteria" id="EFI33252">
        <property type="protein sequence ID" value="EFI33252"/>
        <property type="gene ID" value="Dthio_PD0578"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2070031at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10290" checksum="66F6E7E8A626DA46" modified="2010-08-10" version="1">MNIFKNQENGSVSREIERLDAELEEIRQQKDMCLKRKKTLMSEEKPSEGVFFNDEIHSMQMEALRLEVEAETRRKKINRLRLGYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRF2</accession>
    <name>D6SRF2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0594"/>
    <dbReference type="EnsemblBacteria" id="EFI33268">
        <property type="protein sequence ID" value="EFI33268"/>
        <property type="gene ID" value="Dthio_PD0594"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50300KJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015182">
        <property type="entry name" value="QH-AmDH_asu_heme-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09098">
        <property type="entry name" value="Dehyd-heme_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="87" mass="9618" checksum="BD98062048160C3D" modified="2010-08-10" version="1">MNRFLIFVCAVAVVLFFSLSMDLRAGSHEKGEELVSQKCSTCHGLSRVQDADKSLEEWDSTVDRMISYGAGISQDEKQAVVEYLAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRL9</accession>
    <name>D6SRL9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">Dthio_PD0663</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870693.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0663"/>
    <dbReference type="EnsemblBacteria" id="EFI33335">
        <property type="protein sequence ID" value="EFI33335"/>
        <property type="gene ID" value="Dthio_PD0663"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="403"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="707"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFI33335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="798" mass="89906" checksum="B81C6155821A6C40" modified="2010-08-10" version="1">MLLSLSWLREFTPYKGSIDELSHRLTMVGLEVEEIVRPFTHLAPMVVGRVVEKRQHPGADKLSLCSVDTGSGESLSIVCGAPNVQAGQNVAVALEGTELPGGQVIKKSKIRGETSQGMICSETELELGQDPSGIMVLDDSLVPGTGLCQALDLEEFVLDIGVTPNRPDCLSVLGLAREVAALFDLPLYKPDPALQEDKSRHCPDEVHIDIEDPSGCPLYQARIISGCSIKPSPDWMRYRLMAVGVRPINNIVDITNYVMLEQGQPLHAFDRHLLEGHKIRVDRSRPGFKFTTLDQQERELNDRDLLIWDSEKPVALAGVMGGANTEINDQSTEVLLECAVFNPLDIRQTARRLGLHSESSFRFERGVDQANAPFALDRAAKLMSELGLGRVYQGVSRAEPRPCKPVQVYFRRERANSLLALDVDQNYCRRVLTSLGCEVQEEGGGMQVTVPSYRPDITREVDLIEEIGRIYGLDKTPEHLPKVQKSLHQEAWDSEYRFLGDIKQWARGLGLQEVINYSFVGMSDLDFLGVPLEGRVKVFNPLSEEQDVMRTHLLPGLLQTLKHNLGQGNTRLKLFEVARSFEQDESSETGVRENNRLALLLYGRRHRGHWPHPEDDADFYDLKGLVENLLGVFVGHEGRFVLHKEHPYLDPAVECICREESLGMLGRVRQEKARAYKARKDIWYCDLDLDLLQSLGSLSRPQFQPLPRFPVVKRDMTVVTPMELGYDQLRQVVENAGLDILEDLSLVDVYLPPEQQEKKLTLRLTYRHPERTLKDSEVDKEQQKLADLLLKKLPVGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRP6</accession>
    <name>D6SRP6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870720.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33362">
        <property type="protein sequence ID" value="EFI33362"/>
        <property type="gene ID" value="Dthio_PD0690"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031KXS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1981116at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="115" mass="12959" checksum="4017CF5CE08CCF7A" modified="2010-08-10" version="1">MSQPASVIDLYDSLLAAEDERARARIIAGAFERLEDRYPELKDLATASGVRESELRLQKEIEQIRAEMKIEIERLRTELKTDIAAGNQKVLRWVTGLMFAQLVTIIAIILGSGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRU8</accession>
    <name>D6SRU8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/antitoxin, MazE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870767.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0746"/>
    <dbReference type="EnsemblBacteria" id="EFI33414">
        <property type="protein sequence ID" value="EFI33414"/>
        <property type="gene ID" value="Dthio_PD0746"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8790" checksum="1FCE9B68C0148CD6" modified="2010-08-10" version="1">MEAKAIKVGNRLAFIVPEPIAEKCGIFENTSVDISLRDDEIVVRPQRKKYILSELLAEITPDNIHKEVGSGEPVGQEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRX9</accession>
    <name>D6SRX9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
            <shortName evidence="8">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">serS</name>
        <name evidence="11" type="ORF">Dthio_PD0779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870797.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0779"/>
    <dbReference type="EnsemblBacteria" id="EFI33445">
        <property type="protein sequence ID" value="EFI33445"/>
        <property type="gene ID" value="Dthio_PD0779"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="171"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="8">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="425" mass="48074" checksum="867999586930AF61" modified="2010-08-10" version="1">MLDIKFVRKNPDLVAKSIKDRGAAQDLDDFLKLEQQRRELTQRVQDLKTRRNQASQEVALAKREGRDAAQAMEGLSELSDKIKELDGELKGLDRQVHEWLLSVPNIPAGDVPVGSDEDDNQVVRTWGEKPVMDFQPREHWDLGVELGGLDFEHAAKMTGSRFVMYVGWGARLERALINFMLDVQTGEHGYMETMPPMIVNRDSMTATGQLPKFADDLFKLENWEYYLIPTAEVPLTNIHRGEVLQEDQLPLAYTAFTGCFRSEAGSHGKDTRGIIRQHQFNKVELVRFAHPDDSFKQLELLLGHAEEILKRLGLHYRVVNLCTGDLGFGAAKTYDIEVWLPGQGKYREISSCSNFTDFQARRGDIRFKPAQEKKSRLVHTLNGSGLAVGRALVAIMENCQQKDGSIVIPEVLRPYTGGMDIIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS26</accession>
    <name>D6SS26_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ORF">Dthio_PD0826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870844.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0826"/>
    <dbReference type="EnsemblBacteria" id="EFI33492">
        <property type="protein sequence ID" value="EFI33492"/>
        <property type="gene ID" value="Dthio_PD0826"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="223"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="397" mass="43846" checksum="67CC9381FD2EEA50" modified="2010-08-10" version="1">MENTSLEQKTEKYLCPTYARYPLAVKTASGCRLYDFQGREYIDLLAGISVCNLGHSHPEIVQAICSQAGKLVHTSNLFYQEEQVLLSEKLVETCHLDKVFFCNSGAEANEAAIKLMRRYMSRVRGENRHELITFSGSFHGRTLATMTATGQDKIKEGFAPLPEGFRHVPLNDVQALEDAVNENTAAIMAECIQGEGGIKLMSPEFKKKINELQRSRDILLIVDEIQTGMGRTGSLWAFEQEGLEPDMFTSSKALAAGLPMGALLAREEVASAFGPGSHGTTFGGGPLPSVAALKSLEIIQRDGLLDYCRDLGQWAANRFRETGRKCPGTIREVRGRGLMLGIELEFPGKDVWQALLDRGFVLNLTQESVLRLLPPLTITGQDLEQFALALEQVLQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS99</accession>
    <name>D6SS99_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0899"/>
    <dbReference type="EnsemblBacteria" id="EFI33565">
        <property type="protein sequence ID" value="EFI33565"/>
        <property type="gene ID" value="Dthio_PD0899"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="263" mass="29338" checksum="FA96AF8E6D500576" modified="2010-08-10" version="1">MNAMNEPAPRFWEIFFEVYETLPRQGPGNRASAVRALALCRYLSKSPAILDLGCGVGGQTLYLAELTPGSIVAVDSHTPSIEHLQAAIAQHGLSKRVTAMVKDMDRLEQTPGSFDLIWSEGALYSIGLQHALYLCYGLLSPGGYLVFTDAVWRKENAPAEVKAGFDLDYPDMGWVGDDVASILDCGFDLVGHFTLPDEAWWEDFYTPMEARIESLRSKYAGDDEVSAILDQLAREPEMHRLYCDYYAYEFFVARRPLHIQGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSD9</accession>
    <name>D6SSD9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">Dthio_PD0940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870955.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0940"/>
    <dbReference type="EnsemblBacteria" id="EFI33605">
        <property type="protein sequence ID" value="EFI33605"/>
        <property type="gene ID" value="Dthio_PD0940"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="346" mass="37276" checksum="C25F04F264ABF480" modified="2010-08-10" version="1">MTRILDRLFGAVSNDLAIDLGTANTCVYVKGKGIVLREPSVVAVKRDLRGNNKVLAVGEEAKKMLGRTPGNITAIRPMKDGVIADFEVTEAMLRHFITKVHNSRRLVRPRIIICVPTGITQVEKRAVKESAQSAGAREVYLIEEPMAAAIGANLPITEPTSNMVVDIGGGTTEVAVISLSGIVYSRSVRVGGDKMDDSIKHHVKRKYNMLIGESNAEIIKNTIASAYPLDDEQQMVVKGRDLVSGIPQNITITSEEVRKAISEQVESIVQAVRIALEQTPPELASDIVDRGIVLTGGGALLKGLDRLLMDETSLPITVIEDPLSTVAVGSGKVLDNLDVLKEVTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSK7</accession>
    <name>D6SSK7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin, iron-sulfur binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871022.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1009"/>
    <dbReference type="EnsemblBacteria" id="EFI33673">
        <property type="protein sequence ID" value="EFI33673"/>
        <property type="gene ID" value="Dthio_PD1009"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="538" mass="60938" checksum="F421239CBE37183C" modified="2010-08-10" version="1">MATPKPDVLYRNISHHPPELDWMDVPLEIKPGRYCYAADPSALEAVGMPNARSWNPTDEDWKLPENWKETFLEGMKDRLERFRSFKVFMDICVRCGACADKCHFFIGSGDPKNMPVLRAELLRSVYRGEMTKAGQILGRMAGGRELNEKVLKEIWYYYYQCTECRRCSVYCPYGIDQAEITIIGRELLNLLGLQLDWIGKPVANCNRLGNHLGLPPHTFKDNIDFLCDDIEEATGIKPEPTFNKKGADILFITPSGDVFAEPGIFTCMGYLVLFHYLQEEYGLDITWSTYASEGGNFGFFTSHEMMKKLNAKMYHEAERLGVKWILGGECGHMWRVLHQYMDTMNGPPEFLDVPVSPITGTRFDHAASTKMIHIVEFVADLIKHKKLPIDKTRNDHLKVTFHDSCNPSRGMGFLEEPRYVLNNICNNFYEMPEGTIKEQTFCCGAGSGLNPGENEELRMMGGLPRANAVKFVRDRKGVNTLANVCAIDRATLSASMDYWVPDVTVCGVHELLANALILPGEDRQTDLRGEPLPGKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSM8</accession>
    <name>D6SSM8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma54 specific transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1033"/>
    <dbReference type="EnsemblBacteria" id="EFI33694">
        <property type="protein sequence ID" value="EFI33694"/>
        <property type="gene ID" value="Dthio_PD1033"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="186"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="426"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="730" mass="81325" checksum="9ED143A1949BB0EE" modified="2010-08-10" version="1">MQLSLKGTLILTIAGLVMLSILAVALLASHHYARSQEELLEAQAVNLGHTLGEESTDFVLTNDLVSLQRRLERYKQTTPQVSYLFVQRQDKILAAVFQGNGVPRELIDANQPLDKHTSSLKKIMSKEGDKYLDLAVPMFEGRAGVLRLGFSEEHLSMQVAQLWQGIFSLALVILVPALFIGLVLISRITRPLAALVKAAGEVEPGKKMDVQFNVQGQKEIQALSDAFRRMTSRIQEYTTRLEEQAEALEHAHRRMQTTCEVARNVSALSDMDEIGGYLMRRIKKIIHCPSNLILVFGPDRDVLFVITEKGTYPVSDRQTAQSIDAALQNLQGVETIDGRVFESLPLPEGFVLGEKQVVVPLYYEDILCGAMLASCSSKCKCDSDSMELISLVLSHASGTIRRAILHQEEIKKLKQGVSESAGFEGMIGRDYRMQTIYRLIQDVAPTDVTVLIQGESGTGKELVAKAIHARSSRRDNPFVVINCSAYPATLLESELFGHEKGAFTGAIRQRPGRFEQARGGTVFLDEIAEVDLSAQVKLLRVLQTQKFERLGGEKSIEVDVRILAATNKDLLEEVKAGRFREDLYYRLDVVPINLPPLRERGNDTALLARHFLERFAAVQDKRINEISSSAMRALLDYSWPGNVRELENVMEQAVVLCKGETIALEDLPDKLQGARPARRKTIEDQEKNLLLETLEACGWNKKMAAERLGIGRSTLYAKLKKHGIMDSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSP6</accession>
    <name>D6SSP6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1051"/>
    <dbReference type="eggNOG" id="ENOG50320QR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0711">Selenium</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="274" mass="29722" checksum="D7F7F34AA285CC03" modified="2010-08-10" version="1">MQGQGTQNSRRSFLKGMGTTMAGVAVAGTMGFASHSLLGAGQASAALSGDFPYKKLDKDIAAEMAFKAYMEKGGUGPGAADGLFGYLAQEVGEPYTHFPISMFWVFSSGVRTGWASICGALVPPLALIGAMPVDNQIKGKLCDELMAWYMKFPFPEYQPAGMDLPKVPVDSSLCHVSVTKWMKEAGVARGSEERKHRCGGLTSDCVIKTVEMLNKLADEGAFEVTSKPHESVESCMRCHDNMQPYTHGKENCNACHAMEPVSIDECEQHVDWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSY1</accession>
    <name>D6SSY1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1136"/>
    <dbReference type="EnsemblBacteria" id="EFI33797">
        <property type="protein sequence ID" value="EFI33797"/>
        <property type="gene ID" value="Dthio_PD1136"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="29163" checksum="B9E9F517A0F4B832" modified="2010-08-10" version="1">MAFSMKDVHFALGETSILEDINIDLPPGRIYGILGPNGSGKSTWLDLLIRHRVPQQGMVEYNGHPLGSYSRKQISKEMALVPQDYRLNFPFQVLEVLLMGRYPFLPRFASPGSRDLDIVREVMQKTGLEKFQDRMVTELSGGERQRVVFARALVQDTPVLILDEATASLDIKHGLHLLSLVRQKNQQARTTVFSVFQDINLAAAFCSHIIFFKQGRILLHGPTTEVLTPQNLERVFDVRAKVYFDDYAQSTQVVFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSZ2</accession>
    <name>D6SSZ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871157.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1147"/>
    <dbReference type="EnsemblBacteria" id="EFI33808">
        <property type="protein sequence ID" value="EFI33808"/>
        <property type="gene ID" value="Dthio_PD1147"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZGFC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077740at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="7825" checksum="42589CAE010EDCA3" modified="2010-08-10" version="1">MHIFADGISKVTLSSGNLRIKLTQQGTDNEQIQAGTLIIPASQASSFLNGLAGSLRELDEKLKAQKQEQEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST02</accession>
    <name>D6ST02_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein Dthio_PD1157</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871167.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1157"/>
    <dbReference type="EnsemblBacteria" id="EFI33818">
        <property type="protein sequence ID" value="EFI33818"/>
        <property type="gene ID" value="Dthio_PD1157"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1834382at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7390" checksum="07367059DD7728B1" modified="2010-08-10" version="1">MSLNKEILQILACPKCKSDLTLTGQEEGLKCSECALVYPIREEIPVMLIDEAIPVQDWENGVRAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST17</accession>
    <name>D6ST17_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871182.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1172"/>
    <dbReference type="EnsemblBacteria" id="EFI33833">
        <property type="protein sequence ID" value="EFI33833"/>
        <property type="gene ID" value="Dthio_PD1172"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="728" mass="82279" checksum="8321B1705228105C" modified="2010-08-10" version="1">MKDGKSPISRRRFLQTSMAAAAVGAGIQSPLVKGLVPGANAAGSRPDKDITSHYTACDMCFNRCGMIARKKNGVIKKLDPNPNCRKSRGMICAKGNAGIQHVYNPDRLKHPLKRKGKRGEGKWERISWEEALDHTAEQMQKIADEYSRCGIMFTPGVDAQSRFVEMFAEVFGSYNFTNHESLCLLSRNRAYLDTFGEVPTADVLHSRYIIIAGSNPLEAIMTPDTPDLVEARKNGCKVVVLDPRFTKTAALADEWHQIKPGTDMAFFLAMCHEIVKGERFCCPDNTHGYDKFVEHIKDYTPEWAEKECGIPAEDIKRISKEITEAAPRAMVYPGRRSSDYKQSTQIRRAMAIANVLLDNWDRPGGLMATREVGVRGWDYSPPFYPENPPDRADADQVPGLFSDIGSFQLLREAIIKQEPYPIRGWFSFKTNFLQTGANRQKTIKMLENIDFFVNIDIMMSDTAWYADIVLPGNSFLEREDPVTALQGSSACACAFLRDPVIDNMFESRPPLWILQELAKRMDLEEHFDFTMDEYREAQLRDLEGALEIMRQDGIYFNPSQAYGIYAGDPLKTLSGVKEIYNQRYEQWGIEPMPVYNPPQMPDKDEFRLIVGRPAYFTQSRTNNELLTEFMEENTLHMNPDAAQRLGLEDGDLVEVESSSGKGRLRLEIDGGIEKQTVYMVTGFGSLSPQMSQIYQKGASIAEIQEDAYDEICANMAMHETFVNVRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST26</accession>
    <name>D6ST26_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871191.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1181"/>
    <dbReference type="TCDB" id="9.B.102.1.8">
        <property type="family name" value="the yede/yeee (yede/yeee) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33842">
        <property type="protein sequence ID" value="EFI33842"/>
        <property type="gene ID" value="Dthio_PD1181"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1854883at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="12"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="239"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="398" mass="43748" checksum="66B0A32DCE6ABACC" modified="2010-08-10" version="1">MATTFWSSFREEARKVYIKVFQNSWPIWLAAVFLAILALMIFLWDSMWGITGGFRNWGDNFFYLIGLYSERPTEPWMSNMSMSNIGLVLGALAAALMAGQFKLRNSSWYEYLKGIAGGGLMGIGAAIASGCNIGGFYNAIGMFSMGGYAMMIGLGIGAYIGLRILIWEMMNVPQQFTAAPPSREMPGKAFINWGKISPFAGGLVLVLILTAFYLYSVQGETVLGGLLFFGALIGITMQRARLCFARAFREPFMTGDAEMVRAIALSLLIYGMGSAVIKYNWIQPETMGVFHPFWLGSLLGGIIFGIGMLLAGGCGSGSLWRAGEGHIKLIIAVVSFALFNSLGFAFLERFQVQDWLGSGVFMPDVFGWPLALAVFVLIPVAWALWAIWNEKSEKFVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST51</accession>
    <name>D6ST51_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871216.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1206"/>
    <dbReference type="EnsemblBacteria" id="EFI33867">
        <property type="protein sequence ID" value="EFI33867"/>
        <property type="gene ID" value="Dthio_PD1206"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="889"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="915"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="962"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111275" checksum="2B76952145173F04" modified="2010-08-10" version="1">MNKLSSFAVSRPVLVTMASLIVLLLGLVSLSRVAIDLMPDITYPTISVRTNYEHAGPQEVENLITRPLERAFSAVPGVDEIYSRSVEGLSDIRVSFAWGTDLDAAANDLRDRLDRVAPNLPTDADRPFLRKFDLASFPILILGASSRLDPIEARRLIEDEVRHRVERVPGVAALEIRGGLEREIHVDLLPGKIQALDLSLEEINRRIREANLNFPAGVREEDQHETTVRILGEFTDLQELSGTVIAQRDGSTIRLGDIADVQDSWERITRLVRVNGEPGIRLTINKQSGANTVEVAGQVLQEVERINREFPQLGISPIIDTSSYIQRSITNVAGTLLYGSFFAVLVLLFFLRSLRGTAIVAAAIPISIVATFIIIYFGGFTINLMTLGGLALGAGLLVDNSIVVLENIHRKREGGSPPPQASVSGAGEVAAAITASTLTTMAVFLPIIFIRGMAGVMFTQLAYVVGFSLLCSLAVALLLVPMLYSRCLGPMSCAGGKTGTVGGINAVSKRFFGSLESSYQSLLDTCLRHRALTILTALLLLISSMALVPYIGTEMMPETDEGEVRINIEMDVGSRLEVLDRAALQVEEIVKRQVPEAENVISFLGGVGWRFSGSHLGEVRISLVEESKRDRSSQEIANDLRRELNRIPGAQIRTRAGGGLFILRLGASDGDRVEVEIRGHDLDTSAALSQRVQELVEAVPGISDASISRETEAPEEIITVDRARAESMGVSVSQAGEALRTVLSGSTAGYFRDRGEEYSIRVKLKDAEFMPLDEILDTTVAGLGDTGIALRNLVDVRPGTGPMNIERKDQERIVTVSADFADTSLGEVVRDIRSQLELMPIPQGFSIGFGGDYEEQQEAFGELGLGLILALVLVYMVLACLYESLRDPLIVMFAVPMAIIGVCLMLFLTNTTFNIQSYIGCIMLVGILVNNAILLVAQTNLLRRRDGMLMQSAIREAGRRRLRPILMTALTTIFALTPLAIGAGEGGEAQAPMARAIIGGLASSTLVTLVLVPVMYSFIARKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST54</accession>
    <name>D6ST54_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871219.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1209"/>
    <dbReference type="EnsemblBacteria" id="EFI33870">
        <property type="protein sequence ID" value="EFI33870"/>
        <property type="gene ID" value="Dthio_PD1209"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335DA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2070736at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8286" checksum="65EE964174AED32C" modified="2010-08-10" version="1">MKTEMEIRMQGMQALINKLGLVETERFLAAVSRDRFNYTQWRRTELPELTIEAIAEQGNELADKLNETKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST61</accession>
    <name>D6ST61_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871226.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1216"/>
    <dbReference type="EnsemblBacteria" id="EFI33877">
        <property type="protein sequence ID" value="EFI33877"/>
        <property type="gene ID" value="Dthio_PD1216"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="8">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="379" mass="41370" checksum="3DF4156AC542D0F3" modified="2010-08-10" version="1">MHQTASVDNRSLDYTLKADAEGILHAVVRGRMEAGSIGPLWKELASKLKKNRAGLVLDVEKVDYMDMSGQALLLHFSRQMQDRNLSVEVRGLRPELREIQEEIDCFDCRPRPMQRKLSALEELGRAAVNLGRDTRQFFSFVGEFVSSFAYSLTHPGTVRWKDVLSHMEAVGGRAVFIIALMGFLIGVIIAFQTAITLRAFGAEIFVAKLLGLSIVRELGPLVTSIILAGRSGSAFAAEIGTMKTNEEINALQTMGLSPVRFLVVPRMLAAMLVTPLLCIFFLLFSFIGGALVMLSMDFTLTTYIHQLKTSVGMTDFLGSMVKVFVFSILVAWIGCVRGLQTGSGASAVGRSTTSAVVSAIVLIILADGIFAVVYYMLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6STD0</accession>
    <name>D6STD0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ThiI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1285"/>
    <dbReference type="EnsemblBacteria" id="EFI33946">
        <property type="protein sequence ID" value="EFI33946"/>
        <property type="gene ID" value="Dthio_PD1285"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1230735at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiI" evidence="3">
        <location>
            <begin position="10"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="351" mass="39733" checksum="1C106572A80F31E1" modified="2010-08-10" version="1">MTHKEIDQYHALALFSGGLDSILSIKTIQEQGLKVLGLHFCSPFFGNPQKLEHWEKVYGLDLLALDVSREYVQMLCSGPEFGLGKLLNPCIDCKIFMLQKTRDLLDKYGAEFVISGEVLGQRPMSQRRDALFVILKEAGLKDLLLRPLSARHLPPTRAEREGLVDRGQLQAISGRGRKEQMALARKYNITEIPTPAGGCRLTDQESCKRYLPLLQHHRPGPEDFVLANQGRQFWCESYWMTIGRDKQDNERIQEMVRDDDYMFWLKMHPGPTGLGRNITGSPWPGKVLQSAAALVGHYSPRARKCLRKVDVTVQHKGEQTELSVWPGPDLEGLSWAEPVWDQDAARGLFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6STE3</accession>
    <name>D6STE3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871308.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1298"/>
    <dbReference type="EnsemblBacteria" id="EFI33959">
        <property type="protein sequence ID" value="EFI33959"/>
        <property type="gene ID" value="Dthio_PD1298"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="133"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="389" mass="43190" checksum="F0EB4063D2F5D3FF" modified="2010-08-10" version="1">MLKSQLNHIIGQILSKHPDLSDIILTAGKPIQVEVHGQLADARISPDMGNLVPFQVEAMAMAMMGSDLRLYRDQARTGSCDLSYELPGQSRFRVNVFGQKGSLAVVMRKLAMHVPSLEDLALPQIFQDMAREKYGLILVTGGTGTGKSTSLAALINEINSRESKHIVTLEDPVEFTHPHKKGVINQREMGRDFDSFASGLRAALRQAPKVILVGEIRDRQTVGIALEAAETGHLVLGTLHTSDAGQTVNRIIAMFELSEEQLIRSRLADSLKYVVSQRLLPRTDGGRVAAFEILSSNLRIRDVIMNGETEEKTFYNVISAGETYGMATFDQYLMRLYKEGIIAEETAMLSASDKSRLKQMIDREKSLKGEKVTDIDGLELDLDYENRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUA9</accession>
    <name>D6SUA9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">Dthio_PD0203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871582.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0203"/>
    <dbReference type="EnsemblBacteria" id="EFI32889">
        <property type="protein sequence ID" value="EFI32889"/>
        <property type="gene ID" value="Dthio_PD0203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="105"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="216" mass="24169" checksum="00589F0103106DBA" modified="2010-08-10" version="1">MSELYNLKVEVRNEKGKSAARKLRKNDYVPGVYYDSSGETLPLKVRNGPFYKAWNQVGTTNVVELEYTHSGETHRKPCLIWSIDRHPYKKVYMHVDFYGVDLTKEVTIAVPVEVKGTPKGAEDGGIMRIFRQTLDLTCLPANIPSQVTIDVSKLDIGDNIYIEDLKMPAGAKVTFEENFAVVGLVPPMQEEPEAEAEEGSEEEGAREASEEEAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUF1</accession>
    <name>D6SUF1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0245"/>
    <dbReference type="EnsemblBacteria" id="EFI32931">
        <property type="protein sequence ID" value="EFI32931"/>
        <property type="gene ID" value="Dthio_PD0245"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="25297" checksum="9017761C482C45C4" modified="2010-08-10" version="1">MFIVIEAVINCQQLDVCMRACEIELAVFDYGGVLAEEGFMAGLNAMADRAGLDRDFVFQSAREVILSTGYLTGQGSEEVFWDQFKAATGIKGSPNGLRQDILSRFQLRPWMLELMQKLQTLGVGRIILSDQVNWLDELEARDSFFRYFDQVFNSYHLGKSKNDASLFDDLLKWTGVQAHRAVFVDDHLPHVERAISRGINGIYYTGRDDFLKRFAGFCPGIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUI1</accession>
    <name>D6SUI1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">Dthio_PD0275</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0275"/>
    <dbReference type="EnsemblBacteria" id="EFI32961">
        <property type="protein sequence ID" value="EFI32961"/>
        <property type="gene ID" value="Dthio_PD0275"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="186"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI32961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="360" mass="39614" checksum="8F72DF5351E86602" modified="2010-08-10" version="1">MLNKVLIATGGTGGHIYPALSVARKIKELYPSCRVVFAGGLYGSEKDIIPQAGFEFKAFPAKGVLGRGIKSLGSVWWVSRSLAKSYFLLRSLRPDVVVGFGGYAGFIPVLTARMMKIPTAIHEQNSLPGMTNRVLGRKVKKVMLSYEDIKNFFPPEKVVQTGNPVRTELLEHQYASHGMHQPGKRLLVLGGSQGASAINSAVLERLDELKAMEVRIWHQTGERDYEMVKEAYQEKYPEARVDAYIQDMAGAYDFADLVLSRAGASTISELCVAGKACVLIPFPHATHDHQMINARYLEDAGAAMVLDQSYLDQVNLARVITDLLAMPEKIRDMGRAAKKISHPEAAQNIVQELVSLKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUT5</accession>
    <name>D6SUT5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871758.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0379"/>
    <dbReference type="EnsemblBacteria" id="EFI33065">
        <property type="protein sequence ID" value="EFI33065"/>
        <property type="gene ID" value="Dthio_PD0379"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1994547at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="99" mass="10844" checksum="1759CE196CBA3878" modified="2010-08-10" version="1">MKSSAVLINKDDNVATATKDLDVGEKVLVQDDDSTFEIQVKEPVTFGHKFALSDISQGGQIIKYGEVIGVATRDISRFGHVHVHNVDSIRGTFTDRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUX4</accession>
    <name>D6SUX4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871829.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0013"/>
    <dbReference type="EnsemblBacteria" id="EFI32730">
        <property type="protein sequence ID" value="EFI32730"/>
        <property type="gene ID" value="Dthio_PD0013"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10555" checksum="2A2E12CAA5862206" modified="2010-08-10" version="1">MGKSIEEKHREMLDRDPGYALEYARMEEEFQFVRELIRARVRAGMTQQQVADKMGTTQSTVARLESGGTMPSLRSLQKYAWATGSKVKISLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUY3</accession>
    <name>D6SUY3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871836.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0025"/>
    <dbReference type="EnsemblBacteria" id="EFI32739">
        <property type="protein sequence ID" value="EFI32739"/>
        <property type="gene ID" value="Dthio_PD0025"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033GEX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2085932at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15078" checksum="4EAB63E3F60E3ADF" modified="2010-08-10" version="1">MLQQSAPATRPGLEEVKRQFEHWRETRHTRSPIPNHLWASAVSLAQDYSICKIAKVLHLNHSHLKKRVLAEQAQESLQPGPSFVEFELTSSLPCTEYHLETEARDGSKLKMQLKGPDLPNPLEILSAFWSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV21</accession>
    <name>D6SV21_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871867.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32777">
        <property type="protein sequence ID" value="EFI32777"/>
        <property type="gene ID" value="Dthio_PD0072"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2167472at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="324" mass="36455" checksum="C7AD139297024BF5" modified="2010-08-10" version="1">MTEKSLLTLRDIAELLGIRYRSVIDCKDYFSDYLSSLYDGRHYRYWSDNLDFFELVFTLREHGYTFAMIRDYLTEKQGLSGLQALNNLMSSLTSGAEEEGGRTRRDENEGGGTKRKEDEGGGRRILEEEGENGTRKDGVGECGECFIQNSQLKDELQQELYAAVSSQAELVVQKKIKGLADALEDTLLNLTAEINGSMVQVYKALTQVQEGMNNLEERLGQLENDLGADPAEGVELSDLDLEKMQVSHPSINLVDAESIPQEAQESAPLDDYAYADLEFVRNSIHNGKPDKAAVTQWIRMEKEKDPEISYVELANKLNEAKYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV43</accession>
    <name>D6SV43_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871881.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0097"/>
    <dbReference type="EnsemblBacteria" id="EFI32799">
        <property type="protein sequence ID" value="EFI32799"/>
        <property type="gene ID" value="Dthio_PD0097"/>
    </dbReference>
    <dbReference type="OrthoDB" id="92at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="2245" mass="233236" checksum="58447ECF98D86701" modified="2010-08-10" version="1">MATLVYLGENYNNETFTVNGQLDFRIARGMEYENIEFAIGGNSRDVEVHTDIAAEATFTLTEGIDYDYVVDEDTGSILVQDGDGNTMLSLEVGADLKTVAQVRIGDGEETQIELDPDTSEIKPETRPQHPEDVTINIDEIDPITEGDFLSFGGEVVNDSAIELDYDLTVYIDGDEYDVDESFTVAAGETKPFDFGEITGTEGLDVGEYTITIQYGEYGKTTTTFTVEPEELFTALEASGKKFEDDITVDREIEDEQAYNFSGLTSNSRIEITEDVDLTYVADFGDVTIDVSEGATLTISAAQATALAEAGGSVTGDGSVTVTGLDGDDIYDLSGITASASAEVDTVTLRPDTNLGDIEITVADTHTFTLTAAQADGRTIVGDDSEGAADDGNVFVTDIEGDIAYDFSAIGSENGTVTADDINADDYVDGEITFPAGIQLGDLDITLVSDPELTMAAADADGATIDGDGTVILTGDAAGADLSGISAAGVTIDLRQVTGDFELEGADADAGLMGNTTSPLILTSVQADGQELESAEDIDVHGNMNVDLREITDGGTLTVHVTESQSLSLASRMPGGTVIQLADGVVLTASAAVYESRLSGLNVNEPAEGTAEVKITGSAADVADVTKGGSNAQFSFTVTGDIAADAAAIDLSAITDSLTFESNSISVGENAELTLNVAQANGVTITGDGETKIITGAVEEDTDLTGIANLVDNPTTLTIKDGYTLTVTAEQAAALTSIVNDGDDTGDVEVIVGTDTPVDVDLSNVGVTGTDTFTLQVDATKDLTTAASVDTADIIQISGSYTLTLTPAQADATEITGGTVVVDGDIDGATADFTQVENLTFESDEVNLDSETLTLTASQADGVKITESGGKLNVIFEAGDDGTVNLATGSATAADLYGTAVVSGNMTLAAGEEDKWKEFTSVTVADDVTLTLSAEQADTIDNSSGIIQGAGSVMITGNADGDYDLSGIVTTGLSFQGNSISVDGGKTLTLTPAQADGVSVTGDGALDVIGDLAQDQTVDLTNVAADIEFDGDSPGDLDLDTGAEVQVTVAQADAVSFTVSNDGGTVVLSGTLGTETIDVATNTADLTGVTLNETQDTAEGHIEAITADTVTLSAEQANFVSDLDIDTGTFDLIVQLDAENTGVDLTGMTATGQAVTVQVTEDMELTQHDKLTSTDAVNADIELMDDAELTLTVAQAKVLAGTNKIVGEGTVEVTGTFADGDTAALAGLIGDTGGDAITLDLTQADLTADTDVEANLNAVGGDDLNKVILTADQLVDNITLDMDDFNLEIHANAAGSSIFTNNLENVGAQDVEVIVSEDADLAGNLTNVTDLIVGENTVGISAQNLGRAANVQSDATGTLNVTSASETAVDLTNSGEDTQFAGFAGTLNITEDVALTLDPSVYNETVGTADPTASFTTIDDSDLTDGDTVILAFKHDGNDYAVEVTSDGTRADLAEKLNTELGADFTVVDDGTNLDVTAEDGVNIADARLDVVSFSEITGDGTLVIEEYNADGVLVTQQMLDMISTAKVDVTGADTVPNDLVIPTGQTLIMTQEQLHEGEYTGTGTIQIALVDSEDLDLEDVAETLTLNATVDDSENITGDNIDLQRLDSIEVADTFTLTATAAQITGVTVVSSGEGDDDGSLTVEATTAAMTEDLDLSNVSLGEAGALTVEVTGIQDLDLTENANLGNMTHINITGVAETTYVHMTGDQAHEVDLTADANTQITLYNTAATEYDFSDFDHADAVIDVTDLEGTITFPATLDGDWTMTAAQAHEADFEVTGTLNIVDPHLTPAMDLSALTMTGTVNVEFDLSEYENEAINFTGDLGGATVNMGLGAVMIADADTVDDVTFEGPGTVQVMGDLTGNALSNVESSLDLTKADEGTEPTNMPATVAEGITITLTPAQADGFAVTGLGTVVVEGVSGENLDFSNIESSLNLRDADLTGEVELRDTIGDNLTLTADASLLDEVTIGGDGKVVVLGDASGVDLSGISADMDLTEAEMDETTTFPTVAADQTLTMNITDAEELDIPGNGTIELTGKVETDIDMEDFQVGDNTLEFGDEIEILDGYTLTAESRILHDVEITGQGSVVVKASAGRHILDLGEEVSANISFEIEDDNLTIKGFDAEDDVLNFSNMDLDNPNEPEEAFQQYTLGDDVYAEVVAVDSIWDEKGDIETAGSAFLNEQLAEGSEMIFMSATASEDGDTKIWHWDDTNDDGEIDEGELTLIGVLEDFGKDCLSNITEANFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV49</accession>
    <name>D6SV49_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Relaxosome protein TraY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TraY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871887.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0104"/>
    <dbReference type="EnsemblBacteria" id="EFI32805">
        <property type="protein sequence ID" value="EFI32805"/>
        <property type="gene ID" value="Dthio_PD0104"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008876">
        <property type="entry name" value="TraY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05509">
        <property type="entry name" value="TraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0184">Conjugation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI32805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="9191" checksum="22A3B521F2E8820F" modified="2010-08-10" version="1">MPTSVRLPNEYEQRLDYLAKQTGRSKAFYIKQLIMDHLDDLEDVYLAEQRLEQLRQGNDELIKGDEFWSGLDVDDKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV52</accession>
    <name>D6SV52_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871890.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0110"/>
    <dbReference type="EnsemblBacteria" id="EFI32808">
        <property type="protein sequence ID" value="EFI32808"/>
        <property type="gene ID" value="Dthio_PD0110"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="10809" checksum="A4C2EA89F2F84261" modified="2010-08-10" version="1">MHEKYTAIVRKSSSEYIAVCLELNLVAQGADLAEVERNLREAIESYLEELSSSPETVVEPMPIQEFIEFLNDTELESSTQPSGKYTLLEVHEAGSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJS0</accession>
    <name>D6SJS0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869248.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3576"/>
    <dbReference type="EnsemblBacteria" id="EFI36123">
        <property type="protein sequence ID" value="EFI36123"/>
        <property type="gene ID" value="Dthio_PD3576"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="281"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="362"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="577" mass="66111" checksum="EF1180189A375ABB" modified="2010-08-10" version="1">MTHPESDIKTFIPSRTALVYAVLAGLWIGLSDRAVALLVDDPQLLIQVQTYKGWAFVLVTAIILYCILRQQVLSWEKRTQDLIDREKQYHFLVDKSPLPIFIQTGGSFSYLNSQALNLFRASSQEQMLGKPVIDHVHPDFREKVKQRIQSLNRDKQEVPALEQVFTTIDGKNVDVNVQAVPFNFQGQDGAGVFVQDITGHKKNQEQLRAWHDLMQYIIRHDPSAIAVHDRNMNYIYVSQRYLDDYQVTRDVIGRHHYEVFPEIPDKWRQVHARALQGEVISSDDDHFIRPDGSIDYTRWQCRPWYKADGSIGGIVLYTEVITRLKQTEIQLRELNQSLEQKVRERTARLEELNRELEAFSYSVSHDLRAPLRSIDGFSQALLEDCHDQLDDEGKDYLQRVRSATQRMGHLIDEMLKLSRISKAELKPLPVDLSQLARKVCTELSQENPDHHVDIQIQETLTAQADPALMEILLENLLSNAWKFTKDNPDAAIEVGQKVLDSQEVFFIADNGAGFDMQYAQQLFAPFKRLHSADKYPGTGIGLATCARIVKKHQGRIWADSEPEKGTTFFFTLGGGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJX0</accession>
    <name>D6SJX0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869295.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3629"/>
    <dbReference type="EnsemblBacteria" id="EFI36173">
        <property type="protein sequence ID" value="EFI36173"/>
        <property type="gene ID" value="Dthio_PD3629"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032W1M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1912935at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="236" mass="27020" checksum="A88851F73E73A4DE" modified="2010-08-10" version="1">MKAHFVSEQEVRAVPEVQGTETWNPVHHSLVIDAVENAVRDKGLGIQDKRFELTTGGGNLFASYRLDQGRDGVNWQIGFRNSIAKRFAVGITAGTYTMVCSNLVFAGDFVEFRKHTKGLDTDELFSMSGRAIETTVNRLESLEAWQLDLKNIPLSQRHMRILSFEAMRKQAFPASRFHRFLEAYREEIALNGLTLYSFYHSITRTIRDQSLSRISTRSEVLNQLVQDYQHWLSTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJY5</accession>
    <name>D6SJY5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869310.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3644"/>
    <dbReference type="EnsemblBacteria" id="EFI36188">
        <property type="protein sequence ID" value="EFI36188"/>
        <property type="gene ID" value="Dthio_PD3644"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18450at213115"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9461" checksum="46ED10D5BB8F64F7" modified="2010-08-10" version="1">MQKTKVHYTRYQVDCWLRKTFPDIDWDEVKAELPPIIWRSRWDTLADRCGLPYTRKYIQNLDCEGRGPGSIQQSKGGDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK22</accession>
    <name>D6SK22_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General secretion pathway protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869347.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3682"/>
    <dbReference type="EnsemblBacteria" id="EFI36225">
        <property type="protein sequence ID" value="EFI36225"/>
        <property type="gene ID" value="Dthio_PD3682"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2195527at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025746">
        <property type="entry name" value="PilX_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14341">
        <property type="entry name" value="PilX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="PilX_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="435" mass="47876" checksum="70CD30BF3B06DBA9" modified="2010-08-10" version="1">MFTNIYQMEGSFGNAQKGSALIMALLILLVMSIVVMGMATDSDLDLKISRNLQLKNEAFNNAETGIALATEALRHTVSTCWEGDGADEVPEDFFDFSPKYRLTANSSFGDICDLSQGDSVNLRLYYTEDNDKDDLISVVDLSVFYDNPNYKKGVKLLAVNINEENRAEAIIKSTMIAQKAIHSSFNVGIVSESDITINGALDEDFKGSMHANGEVIQTGGGGGGKILGDVTIVKEEHGIYNEDDDSFEKVGAEIIGKKNYGEGFRKQIRKIEEDDLIFWREYAQDHGQYYSEDVTLDNISNDEEFIFVDGDLVISSQADMPRDITVIASGDIDFRGSPKWDDAEDDYDTVTTSVIAGGDITFAGSGEKHAIFWSNGSFTHNGSAKIKGSIVAADKIQNPDVELHGTFEFEHSENIDNAFLPNQICIDQVSWTELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK26</accession>
    <name>D6SK26_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869351.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3686"/>
    <dbReference type="EnsemblBacteria" id="EFI36229">
        <property type="protein sequence ID" value="EFI36229"/>
        <property type="gene ID" value="Dthio_PD3686"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="143" mass="16316" checksum="D30A54FAAC9DFF9F" modified="2010-08-10" version="1">MEEITCPYRKNLASRERDVLLRDLSTYLEPRPELVFAYVYGSFVSGMPFQDIDLALYVDLEHLGNVRSIEEEYAEILSNVFRQVFHVVIVNHAPAPFLCSVFSDGVRLFCKDDELLSSCIEQCSLDMLANEGVSRQSLEEIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK77</accession>
    <name>D6SK77_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3743"/>
    <dbReference type="EnsemblBacteria" id="EFI36280">
        <property type="protein sequence ID" value="EFI36280"/>
        <property type="gene ID" value="Dthio_PD3743"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="207" mass="22966" checksum="3375EF917C205FEF" modified="2010-08-10" version="1">MSLRDSSPGRLYYRGLENAVLPFIKNRGFTPNRVTFAGLVFAIMVPLGFSAHAFWGLLLIALAGIADSADGLLARDSGPKSSFGVFLDSTLDRIRDTFFLMGFWVLFWLDGRWILEATILFFLALLSMYLISYIKAGAEAAGLDCDTGLMTRSVRVVYMLVWAFLLVVVPGTAEALLWIGISVFLLACAFTVGQRIVHVRNQYSFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKL3</accession>
    <name>D6SKL3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868358.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2633"/>
    <dbReference type="EnsemblBacteria" id="EFI35224">
        <property type="protein sequence ID" value="EFI35224"/>
        <property type="gene ID" value="Dthio_PD2633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="87" mass="9542" checksum="64F2D31BA95F6E3B" modified="2010-08-10" version="1">MNNKETIKAPADANAPAGAKRRWARILVTSSLLLILGIGVAYLHSLPVVQEVKQAFRESGIDVSAFTYSDVEEYRDVKSGLRADPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKM3</accession>
    <name>D6SKM3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase orf1 for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868368.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2645"/>
    <dbReference type="EnsemblBacteria" id="EFI35234">
        <property type="protein sequence ID" value="EFI35234"/>
        <property type="gene ID" value="Dthio_PD2645"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2088406at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="113" mass="13369" checksum="DBBC87DF4DF7BD30" modified="2010-08-10" version="1">MQTKSQKYTPEERAGFWSAHINKWRQGSLTKAEYCRRAELSKHAFYYWCKKLGHTYSRKTQEENAIVPVPLKVVQEKTHTPLRLMVNNYRVDIPGDFQQEVLAKLVRTLEEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKQ0</accession>
    <name>D6SKQ0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868394.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2672"/>
    <dbReference type="EnsemblBacteria" id="EFI35261">
        <property type="protein sequence ID" value="EFI35261"/>
        <property type="gene ID" value="Dthio_PD2672"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1440645at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="102"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="205" mass="23067" checksum="98F5E15EC2FDC67F" modified="2010-08-10" version="1">MSQDNAGKAEHVLPPLPFAQDALEPVISARTLEFHYGKHHQTYVTNLNKFISGTDLEGKSLEEIVQATHNKADKVGIFNNAAQVWNHTFYWNSLSPQGGKEPPAALKQKMEEAFGSVDDCKKELHSAAVTQFGSGWAWLVLEGGRLKVTKTLNADMPLVHNMKPLLTIDVWEHAYYLDYQNRRPDYVQAVLDKLANWDFAASNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKU4</accession>
    <name>D6SKU4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868437.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2720"/>
    <dbReference type="EnsemblBacteria" id="EFI35305">
        <property type="protein sequence ID" value="EFI35305"/>
        <property type="gene ID" value="Dthio_PD2720"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="132"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="348" mass="39345" checksum="92618C908EDD43F4" modified="2010-08-10" version="1">MINTAVIGLGKMGISHCAIINAHPKFNLVAVSDTSSLLLRAIEKFSSFKPYSDYRKMIEQNVLDAVFVATPTNMHADMVMFALENKVHIFCEKPLGLNVTQSKDMADKVKKYKLIGQVGYHNRFLSTFNYMKKLLNKSLIGDIYHFTGEAYGPVVVKAENKKTWRSRKSEGGGCLFDYASHVINLIEYVFDNIQTVDSVMLKKVFSTSIEDAVYASLTLTNAISGTLSVNWSEETYRKMSTSLKAWGTKGKIIADAQEIKIYLKTQSSEFGLEKGWNTRYITDFTADSGFYLRGEEYSAQVDYFDYSIKNNLQDNINSFDQAYKTDLVIDLMVNNFKRERGDGQNITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKU8</accession>
    <name>D6SKU8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868441.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2724"/>
    <dbReference type="EnsemblBacteria" id="EFI35309">
        <property type="protein sequence ID" value="EFI35309"/>
        <property type="gene ID" value="Dthio_PD2724"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="359"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="605" mass="68072" checksum="E26B25882F2C9F48" modified="2010-08-10" version="1">MKTWYNLYSFFSASEKWKFLLVLAMILIMALLEVAAVASLMPFLAVLGNPEAIETNIWLNKVYVTLNFSDKDAFLFFLGMVVLCLLVVGSAFKSLTTWAKFRFIHMRGYSLSQKMLRHYLSRPYTFYLNRNSSDLIKNVLSEVDNVIRGIMVPGMEMATSMIVVVFMALLLFLVDPVLVFIIVTMLSLAYLIIYKFIRHKLNVKGKDRVTTNMERYSITQEVFGGIKDVKLLGLESKYQKRFSQPAREFYLKLAFQETAAKLPKFFMEAVVFGGIVILALYFLNRMSGLDSILPVLGMFAFAGYKIMPALQQIFSALTKFRFSAPALDLVHRELNDVKSNEVQNHKRDQKNGIKAQHTIMLDHIYFAYPGSANNTINDLTLQIRSGSVVGLVGSTGSGKTTLVDILLGLLTPDRGEFMVDKTLITPKNIANWQNMLGYVPQNIYLSDTSVASNIAFGLPDEEIDMQRVVSSSSKAKLHDFITHELPGGYNTVVGERGIRLSGGQRQRIGIARALYREPQILVLDEATSALDNITEKSVMEAIAGLEGNTTVIIIAHRLSTVEHCDMIHILEQGRIKTSGTYEELLSRDHGFQMMVMAARSHEHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKZ0</accession>
    <name>D6SKZ0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868483.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2766"/>
    <dbReference type="EnsemblBacteria" id="EFI35351">
        <property type="protein sequence ID" value="EFI35351"/>
        <property type="gene ID" value="Dthio_PD2766"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="253" mass="27816" checksum="00AF2ABCD847E436" modified="2010-08-10" version="1">MLDKFMQAKAGELKALRELKAGGGTLEEYQGPRPGFREAVAGPGPAIIAEYKRSSPSRGVINEELSPQKAVQEFMSGGAAAFSVLTEEEYFGGRIEYLEEFAGHGVPVLRKDFIFDYLQVEQTAATPASALLLIARVVKDLGLLSDLIRVSRIHNLEPVVEIFAPRELDMVRQAGADIIMVNNRDLDRLTVDLDMSRNLVPQKKPQEVWICASGIDNSAQVDELYGLGFDAFLIGTSIMSCDQPGEKLKELFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL13</accession>
    <name>D6SL13_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2790"/>
    <dbReference type="EnsemblBacteria" id="EFI35374">
        <property type="protein sequence ID" value="EFI35374"/>
        <property type="gene ID" value="Dthio_PD2790"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="152"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="375" mass="42444" checksum="EB2E2CCFE85828C2" modified="2010-08-10" version="1">MIPDFSGEALNNYLAEHAAIILMTLDVDGRIQQANRFTHNLVGKDVTGRLLSEVIVDFTGSFDLQNALQQEDEQHLFNVNSHSGLPQTFYFRFMEQNGKILAVGELNHLETEELRRNLVQLNNEFSNLNRELQKKNIELTKLNELKNHFLGMAAHDLRNPLGAIRNLSEFLLEEARDSLSDEYIQFLELIHTSSNFMLSLLDQLLDIARIEAGKLELDFQSTDLISLIKSVVDINKILAEKKKIQIRLEHFETIPYVELDSMKIEQVMHNLLSNAIKFSPEGNLIKVHVFLSGEHVTVAVTDKGPGIPEEDIQKLYQPFTKTSVKTPEGEKSTGLGLAIVHKIILGHMGKIWVESKVDQGTTFFFSLPVKAESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL33</accession>
    <name>D6SL33_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">Dthio_PD2810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868526.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2810"/>
    <dbReference type="EnsemblBacteria" id="EFI35394">
        <property type="protein sequence ID" value="EFI35394"/>
        <property type="gene ID" value="Dthio_PD2810"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="357142at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="399" mass="44637" checksum="C8F513832E668C42" modified="2010-08-10" version="1">MSGIDKVVLAYSGGLDTSVILKWIQKTYDCEVIAFTADLGQEEELDGLEKKALSTGASKAYIEDLQQEFVTDFIQPMFRAAAVYEGRYLLGTSIARPLIAKRMAEIALAEGAQAVAHGATGKGNDQVRFELSTMALAPSLRIIAPWREWDLHSRTELLEFARQNNIPVPVSQEKMYSCDRNLLHLSFEGSELEDPWLEPEKGSYHLAVPPEQAPDEPEVITLGFEKGNPVSINGAEMDPVQLFKRLITLGGRHGIGRLDMVENRFIGMKSRGVYETPGGTILYAAHRDLEGLCLDRESLHARNEMVPGYARLVYNGFWFSPEREAMQAMMDKIQENVTGEVRLKLYKGGIYPLGRRSSLSLYNPELATFEADQVYNQQDAAGFIRLQGLRLMSVNKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL38</accession>
    <name>D6SL38_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868531.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2815"/>
    <dbReference type="EnsemblBacteria" id="EFI35399">
        <property type="protein sequence ID" value="EFI35399"/>
        <property type="gene ID" value="Dthio_PD2815"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195920at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="682" mass="77221" checksum="749D893F85C69BE3" modified="2010-08-10" version="1">MPKQIKKRDGCMESWSTDRIAHAILKALKASGIKDPLLASRLARKVEGKLHEDIPEQETVQDMVEMVLMESRLYDAAKKYIIYREKRRELRCQDQAYLNIGEIIDSYVYKSDWRVNENANMTHSFQGLMLHLSGSVQARYALEKYPEEVRMAHEHAYFHIHDLSFGLAGYCAGWSLRDLLLEGFNLEGKCSSGPAKHFDSALGQMVNFLGTLQNEWAGAQAFNNVDTYLAPFIRHDGLNYHEVKQAMQKFVFNLNTTSRWGGQSPFTNLTFDLVPPKHIAGEGAIIGGRITDDAYGDFEPEMEMINRAFLEVMLEGDYHDRIFSFPIPTYNVTSDFPWDSSVGRLLLELTAKYGAPYFQNFINSDLSPEDVRSMCCRLQMDLRELKKRTGGLFGAGDLTGSIGVVTLNLPKLAFLAQGEEDFLDIITEYAGLARDSLEFKRKLIQDNMERGLFPFSRRYLKNGLTNHFSTIGLIGGHEACINLLGKGIESDAGTRLMQRVLNHLRDLTRDYQETTGNLYNLEATPAEGTSYRLAKTDKTLYGQIYASGNGTPYYTNSTTLPVGATRDVFRALEHQDGLQPLYTGGTVFHTFLGEAVSDLDALKNFIVKAMTMTKVPYISITPTFSVCKDHGYLPGEHELCLHCSREAEVYTRVVGYYRPVKLWNRGKQSEYQDREVYQVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL65</accession>
    <name>D6SL65_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868558.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2846"/>
    <dbReference type="EnsemblBacteria" id="EFI35426">
        <property type="protein sequence ID" value="EFI35426"/>
        <property type="gene ID" value="Dthio_PD2846"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1515392at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088095" description="Nickel/cobalt efflux system" evidence="8">
        <location>
            <begin position="24"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="312" mass="33505" checksum="2B331A1A446937AB" modified="2010-08-10" version="1">MTSRIFTLLLLSLILFSPWTSFAQSPFQAPPEKPEEKKEQGFQPGDLVPDWVKEKGQASMARIMAWQHQIRQNAGGYARQIREDPWGSAFWSYLGLAFAYGVVHALGPGHGKAFVGTYFLSRKASIKQGLMVGSVMSFLHVLSAIILVMGVYFIFKTGGMGPLDQAEARMQKISAGLIFLVGLFLAWKSGRAMLHGNAGECGCCSTRADNKSLLSLALAVGLVPCPGAALILFFSITLDIMFAGLVAMVFLAAGLTLVTASFALAALFARNLLAKATTAGSIISPRLYHLPAMIGAVLISLLGIALYFNPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLC6</accession>
    <name>D6SLC6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868619.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2910"/>
    <dbReference type="EnsemblBacteria" id="EFI35487">
        <property type="protein sequence ID" value="EFI35487"/>
        <property type="gene ID" value="Dthio_PD2910"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="26703" checksum="41E418C29193FC37" modified="2010-08-10" version="1">MSELKDSTMIVTGASMGIGRALALGLAHEGVNLVLNARSREPLHETAQNCSGHHVMVRTAAGDISRVETVKQCVEKAREMGGLSGFIHAAGILSPGAYLWEMQEESFNEVMDSNVKASFLLVRYAVPEIMNRQNGLAVFVGSGAAEITQPGIGAYCSAKAAQEHLARQLAAETDRITCFVFRPGIVDTRMQDQARQAQGGAAGHLHRVFRPWKERGELLTPEQSAAGLIKLLKGDLNKLHGGIFRAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLF2</accession>
    <name>D6SLF2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2937"/>
    <dbReference type="EnsemblBacteria" id="EFI35513">
        <property type="protein sequence ID" value="EFI35513"/>
        <property type="gene ID" value="Dthio_PD2937"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8298" checksum="D53E96B246F5938C" modified="2010-08-10" version="1">MSNVPAIRLYQSCGFKEVGRREKYYTDTGEDALVLQLELAHALKLPSVRKSNSGFARNPIKKRAFLTGLTGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLH7</accession>
    <name>D6SLH7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868670.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2962"/>
    <dbReference type="EnsemblBacteria" id="EFI35538">
        <property type="protein sequence ID" value="EFI35538"/>
        <property type="gene ID" value="Dthio_PD2962"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087971" description="FGE-sulfatase domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="552" mass="62540" checksum="645672E54251B25A" modified="2010-08-10" version="1">MHFCLFVSVFFILLLFRAEAGMAAPPAGPDNPRPDEADIVLPMPGDSVMVFRKVQVPGQGYWGDEEQIIQMGDASGGIFEGLQRTQISGSFPADDGRGQAIYLAKYELTRGQFASVMGLDTLIEASADPDASQLAELEGRALQEAMMVPLSFVSYQDIQEFIRSYNQWLFDAEHPERLENIPEIDGIPGFIRLPSEEEWEFTVRGGLPAIEDGTFNDRLPFAMQRINEYAWHLGNASHRVRPIGLRQPCRLGFFDMLGNVQEMTAGFFRPEVWQGKPGGVSVRGGSVSTPVSDMRSSLRQELDVYAWNQDQERVQERRSFNTGARLAIGSNVVVNTRVRAAMEDEYQEYKDMVRKAMPVGRTMDNLVAQAAGQLGDVEPILGRLMEEHPHLSDDLHTVQEFMDQARQRLDMAQRESARSLAQDAARNGVNLSVYISRLVSLENSLEAARRLAEMSSRYLEQVSAVEQRIKELSSAQKEQFQAYTDKVGELGDYEQDYIDQALESMREQEPLPREKAVLQLLTTHVEDFSQHRRADREGWFKEYEEVFKEFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLN8</accession>
    <name>D6SLN8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868728.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3027"/>
    <dbReference type="EnsemblBacteria" id="EFI35599">
        <property type="protein sequence ID" value="EFI35599"/>
        <property type="gene ID" value="Dthio_PD3027"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1822052at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="149" mass="17385" checksum="9CC1D6F324B4BCA3" modified="2010-08-10" version="1">MNRQELIKKAAEIKTPSKQAARQFQEASPSLVDELNQIMCSRSDLEKLIGKNNREMMLDNHNNHARFMSALLVDYRPEVLVDTVFWVLRTYRAHGFQPAYWPAQLNAWLQLFQKHLSPEAYEEVSPVYNFIIVNQAFFDRSNPACPEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLP6</accession>
    <name>D6SLP6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease 3</fullName>
            <ecNumber evidence="7">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribonuclease III</fullName>
            <shortName evidence="7">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rnc</name>
        <name evidence="11" type="ORF">Dthio_PD3036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868736.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3036"/>
    <dbReference type="EnsemblBacteria" id="EFI35607">
        <property type="protein sequence ID" value="EFI35607"/>
        <property type="gene ID" value="Dthio_PD3036"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="156"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="232" mass="26071" checksum="93175DA91AD5D5B0" modified="2010-08-10" version="1">MLDELQDKIGYRYQDPELLVRALTHSSYANERHMEHNERLEFLGDAVLELCISNVLFFRFPRAPEGHLTRLRAALVSEPTLARLARSLTLGDYIFLGRGEELQGGRDRDSVLADTLEAILGAVYLDSGYDGAFECIAALFEDFIPDRVEALPVSKDFKSRLQEKTQGLFRARPVYTLIDSYGPEHEKIYRVQVELPDGTGIEAMAGSVKKAEQKAASKALEYLDSVKTADVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLP9</accession>
    <name>D6SLP9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMMECR1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868739.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3039"/>
    <dbReference type="EnsemblBacteria" id="EFI35610">
        <property type="protein sequence ID" value="EFI35610"/>
        <property type="gene ID" value="Dthio_PD3039"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1812209at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="183" mass="20672" checksum="A6487BBC1ADFAD0F" modified="2010-08-10" version="1">MSSSVFEISTQEQEYLKELAFLSIKSRLEGSEPDYPLPPSDKLKENLGAFVTLKIQGKLRGCIGNIVGEGPLWKTIIRMAREAAFNDPRFPELTPGELEQVELEISILSPLEPVPDTTLIEPGRHGLVVRKGPYSGLLLPQVAQEWGWDRETFLAHTCRKAGLHENCHKDRDVEIFWFQAVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLU8</accession>
    <name>D6SLU8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3088</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868788.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3088"/>
    <dbReference type="EnsemblBacteria" id="EFI35659">
        <property type="protein sequence ID" value="EFI35659"/>
        <property type="gene ID" value="Dthio_PD3088"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="212" mass="23051" checksum="FB8621CE3E5ACBBB" modified="2010-08-10" version="1">MKTHNKIRCSLQEHKTDIGCNSSWTVPNALTLARFAMVPVFLGAFIHEAYLLSLAVFILAGITDALDGFLARTLEQRSRLGAVIDPVADKLLVLTAFLCLGHVGWIPWWLIVVVVLREILIVSGFAFFRFTGMDVRGKIAATLDSKLNTLGQIMLVLSVMSSIVFEAAALDPVSGILIYAVGGLTLISGLHYLLLGLGLVFFSGNDEKNTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLW3</accession>
    <name>D6SLW3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868803.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3103"/>
    <dbReference type="EnsemblBacteria" id="EFI35674">
        <property type="protein sequence ID" value="EFI35674"/>
        <property type="gene ID" value="Dthio_PD3103"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="594" mass="67079" checksum="5161F882A7499F5B" modified="2010-08-10" version="1">MQQAPSTEYSPENTKTGGRYAYLLNTGAISDHDLQQAMRVAKKENLRMDDVLVERLKVDKQALGRSLQEYYDTDFVSFDHSYVAPFELFEQKRLDPEFLKKYEWVPLEKEGGNIIVLVNNPYDLGRLDEIRFIFGTSNIVARVAIPGDIRRFIEHFHQQYLAEQSMAFLGEEDGSAAEESEATTDYIDEGELTEHDSEVVRLVNALLLEAWRRKASDIHIEPSPGSRYCLIRMRVDGTCHEFKKIRLALAKPLVSRLKIMSSLDIAERRLPQDGKLKIKLPEVSQVLEFRVATVPTTGGQEDVVLRVLTSGKPITLKELGLSSNNLEHFDKLIKKPYGLILVVGPTGSGKTTTLHSALSCINTPDKKVWTAEDPVEISQEGLRQVQVNPKIGLTFAHLLRSFLRADPDVIMVGEMRDRETAHIAVEASLTGHIVFSTLHTNTAPETITRLLDMDLDPFNFADSLLCVLGQRLIKTLCPRCKEKYNPDSAELQELEMEYGEGFNAWKEHYFHKKAVLYRGKGCRDCIGGYRGRLGIHELMLNTDKIKDLIKFRKSAEEIRQQATMEGMLSLKQDGIHKVLAGLTDIHQVRAATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLX7</accession>
    <name>D6SLX7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3117"/>
    <dbReference type="EnsemblBacteria" id="EFI35688">
        <property type="protein sequence ID" value="EFI35688"/>
        <property type="gene ID" value="Dthio_PD3117"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033CU6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942789at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087876" evidence="3">
        <location>
            <begin position="27"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="465" mass="52925" checksum="88DB75006CFCD745" modified="2010-08-10" version="1">MKKHLFFIAILPFLMCTLLFFASQHATNQEAGAEELNGSPADSQDALMDQESTRVMQLEDELHALERELSRKFSELEEQISRDQSLFREYLDIHRQDIHEVETGLEEHEASIKQLQDRLEKAESSLEELREIKDSLQQAVQGMEVSHEQVDSRLEELSKKLSGIDAEYSKQLERIGELGELQESLADFEKALQQKESELRSELESQAERISSELEQNLKNQQETVEGIETELRDKISQLSREIEYTDQGLADRLQETDAGLRDLEDAMDERILYTAGAAALALLLGLTGLAGAIGARRGRRKLQKLVEETSQELRNEFQEQQALQDSKLAELLESLSLVMPQPGQQQDGTQGDPGQQEIDHALALSLADELYKLVKRSRKLPEDETTRDIKSSLSRSYKALKEKGYEIVDLEGRQYKEDMEARVEFVLTHELLPGEQVVSRVFKPLVKYRGNTIQEAEIEVLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLY2</accession>
    <name>D6SLY2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="3">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3122"/>
    <dbReference type="EnsemblBacteria" id="EFI35693">
        <property type="protein sequence ID" value="EFI35693"/>
        <property type="gene ID" value="Dthio_PD3122"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="7">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="1-cysPrx_C" evidence="8">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14231" checksum="82C5414EA54E48F5" modified="2010-08-10" version="1">MFVHKMWDDHELCKMIEGGVPFPMLSDGGGRVGKVYGVYDEDAGVENRGRFIIDPDGVVQGYEVLTPPVGRNVEETLRQIRAFQHIRETKGGEATPSGWRPGKMTLKPGPDLVGNVWKDWKVEMAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM03</accession>
    <name>D6SM03_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3143"/>
    <dbReference type="EnsemblBacteria" id="EFI35714">
        <property type="protein sequence ID" value="EFI35714"/>
        <property type="gene ID" value="Dthio_PD3143"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="842" mass="91076" checksum="A7D350C62B2A55A8" modified="2010-08-10" version="1">MSEDKKTFGLDKPPESLKENSGKNNPPVILKITGMSCASCVRRVEKALTDIEGVRTAEVNLSTEKATVFLEDRVSLAELTEAVESIGFGAQPVDQHQAVLDIEGMTCASCVRRVEKALSDVPGVLQAEVNFASERALITYTGGPETLASLQKAVEESGYKVVHAGTEQKESEDREREVREKQMKRLVRDVVSGAAVTTVVLIGSIPHMMPMWSDWVPAFLSNVYVLLILSTYVQFVAGWRFYQGAYGALRHLTADMNVLVAMGTTSAWLYSAAMTLFPGFLTNLGFPYQLYYDVATVITTLILVGRLMEARAKGRTSEAIRRLMGMQARSARVRRNGEDIEIPVEEVQLGDVVLVRPGERVPVDGEITSGSSTVDESMLTGESMPVTKKPGHEVIGGTINKVGSFQFRATKIGRDTALARIIQLVEQAQGSKAPIQKMVDQIAAYFVPAVLSVALLSFVFWSIYGPEPQLTFALTTFIAVLIIACPCALGLATPTAIMVGMGRGAENGILIKNAETLQLTHKLQTVVLDKTGTLTRGEPQVMDLLPEQGTEAHDLLRLAASVEQGSEHPLGEAVVRHAREQGLNLGSAESFDAVPGQGIKAFMEGTEILAGNLRLMQQFKVSTGPWEERAMELAHEGKTPMYVARDGKMAGMIAVADPLKDTSREAVQDMRKMGLEVIMLTGDNQATARAIGRQLDIDRVFAEVLPQDKADYVTSLQQEGRRVAMVGDGINDAPALASADVGIAIGTGTDVAMETADVTLISGDLRGVPTAISLSRATTRTIRQNLFWAFIYNIVLIPVAAGVLYPFYGIILNPMLAGAAMAVSSVSVVTNSLRLRSFKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM74</accession>
    <name>D6SM74_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868914.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3220"/>
    <dbReference type="EnsemblBacteria" id="EFI35785">
        <property type="protein sequence ID" value="EFI35785"/>
        <property type="gene ID" value="Dthio_PD3220"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1425269at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="291" mass="31480" checksum="D1F8DD11D20EF466" modified="2010-08-10" version="1">MGFREAVESGKFLITAEVGPGKGTDMHELLEDAEAIKDRIHAINVTDLQSSVMRLGSLAVSHILADKGIEPIYQLTCRDRNRLALQSDLLSAWVLGIQNVLALTGDHPVLGDHPESKPVFDCDSVSLLQMMQTLNGGHDMAGNELKGVPDFFPGAVVNPGADAGAGLEMQLIKLEKKIEAGARYIQTQGVFELDSFEKFMKRVEGFNVPVMGGIIMLKSAGMAKFMNKNVAGISVPESQIKAMTDTDDKVKTSVEIASHLVKGMKDICHGVHIMAIGWEKKIPMVLDEAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM96</accession>
    <name>D6SM96_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868936.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3242"/>
    <dbReference type="EnsemblBacteria" id="EFI35807">
        <property type="protein sequence ID" value="EFI35807"/>
        <property type="gene ID" value="Dthio_PD3242"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1684509at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024264">
        <property type="entry name" value="DUF3786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12654">
        <property type="entry name" value="DUF3786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="5">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="273" mass="30825" checksum="653267FC2F657FE4" modified="2010-08-10" version="1">MSKNLNPMQIYQLLNQSNCRECGEPTCMAFAASVFKGHKQLSACPYVDKETLNKYSDLEPARTGTEENMQQAMHYLQQKIPETDLAEAARRTGGIFENQKLTLQIMGKNFSVDTKGGLDSEIHVNPWVSIPVLQYILHGKGKEPTGNWAPFKELPHGRPRAGLFEQRCEKPLKRVADNYPDLFYDILDLFDAMEVDKGFRADVSFLLYPLPRLPMIIAWWYPAEDLESALHIFFDETAKDNLGVDGVFALGTGLAMMVEKLALRHGVKGFIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMI2</accession>
    <name>D6SMI2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amphi-Trp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869022.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3332"/>
    <dbReference type="EnsemblBacteria" id="EFI35893">
        <property type="protein sequence ID" value="EFI35893"/>
        <property type="gene ID" value="Dthio_PD3332"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2082868at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20068">
        <property type="entry name" value="Amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amphi-Trp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="131" mass="14313" checksum="2386258A18EBB055" modified="2010-08-10" version="1">MSKNELKYKAVLGKDQVIEHLESLMHAVKEGRLNVQHEDQSLCLAPGENLKLEIKAGAKENKEKIEFELSWSENMELTDQVGQLNISSTEPEVESFSENPLQEGDASSRSPASSGPAIVAGDESSGEKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMI3</accession>
    <name>D6SMI3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3333"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <keyword evidence="2" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="2">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="8217" checksum="55378DD7FB408EE8" modified="2010-08-10" version="1">MKKEHIMPRTIIYGKSTUPFTNKAREAYKDHDYVDVVEKPEELQKMLELSGGKRKVPVIVQGENVTIGHNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMI8</accession>
    <name>D6SMI8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">Dthio_PD3338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869027.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3338"/>
    <dbReference type="EnsemblBacteria" id="EFI35899">
        <property type="protein sequence ID" value="EFI35899"/>
        <property type="gene ID" value="Dthio_PD3338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1371775at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="128"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="448" mass="50435" checksum="AEEF258AE793AC91" modified="2010-08-10" version="1">MAHIFNVSELTAAIREVVEMHFPFVWVRGQATNVSRPGSGHIYFTLKDEQAALQVVWFKNTQAASRKQNSDPAASLDNGQEVICAGRIGVYPPRGTYQLIAELVQEQGLGDLFLAFEALKARLQQEGLFEAERKMKIPFNPERVGIITAPTGAALQDFMRVADDMGHGSEIIVYPSLVQGDKAPADIVRAINRACREDRVQVLVLMRGGGSLEDLWAFNSEEVARAIAGSHIPVITGVGHEVDTTIADLAADLRAATPSHVPQHLWLQRKDLWVRLDEQEMLLVQAYKRFLKTREEQLQNMSRGLGWLSPARQMQRREEQLDSLEQALKREGGNFLDMYMRMVQELESRLRGKFSPDYWEVRHQQLDYLQQTLKARAVNFLEDRENKVSFAAEKLESLDPYAPIRRGYSLVTVAKSGKFLRSVHDVSPGDVLEITVIDGQIKSRVGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMJ5</accession>
    <name>D6SMJ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent DNA helicase, RecQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869034.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3345"/>
    <dbReference type="EnsemblBacteria" id="EFI35906">
        <property type="protein sequence ID" value="EFI35906"/>
        <property type="gene ID" value="Dthio_PD3345"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="309"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="520"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="1110"/>
            <end position="1117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1702" mass="191926" checksum="FC817D6230C86B36" modified="2010-08-10" version="1">MTTLTREKIIDLTLSREFQNIVVLDLEIHPERKTLIKIGATGPGWQPRLAFQGNFRADEALSRLEQSFGRASFMLGHNIIGHDLPWLRKHFPEFSLLKLPALDTLHLSPLAFPKNPYHHLVKDYKLVRTAKNDPIQDCAQAELVFQDEIQAFQALPREQLIFYGTLMHRSHPESGLGHFFAVLAGADLKDKEWCKSFWEENAGGHACVSHAQSAFETLWDDSRESCSLAYILAWLQVSGSNSVLPTWVWKRHAAIPGILRSLRETPCSDPACSYCSSAFDYRAQLQRYFGYPDYLPVKDEDPPLQRLVVETLIRGNDCLAVLPTGAGKSLCYQLPALMKAEQGKRLSIIVSPLQSLMKDQVDGLLRKGILQGCTINSTLTLLERSQALEGIRMGDLDLVWISPEQLRNTTVKDALRSREIAMVIMDEAHCFSKWGHDFRPDYLALASFLDEICPGPPHPEPQIACFTATAKKDVVDEILDYFRNEMGRDLVLFQGGHERSNLRFDVIPCAEPEKTQRMHSILQSVLVDKEDGGGIVFASTRRKTKEYAEALEHMGWNVEYYHAGRTPEERTSVQERFLAGEIQVIVATNAFGMGVDKPDVRVVIHASAPGSLENYLQEAGRAGRDHRPAVCCLLFDPDDLDTQFELCRASEISARDIRSMYGGLKSLASSRNNPDMVMTSGELLASEEFEEYGFDTLDSHEPMADTKVRTALSWLERRGKIRRGDNKTTAIQGRLLVKDKEEALKIMGGLNLSPSEHALWMALLDIIMQADPKELLNTDMLSARLGAEPDRILRSLGAMRQARILNHDLNMTAYLRKGIQDDSRSRLREYLGLEESLFALMEEDEPDARAGVVYNMPLRPVCQRLKERGHTEAAPAKLLHILKLLVDEKLLRLHQLSQNSYQVILQHEWDRIRQHASRRNQSARVLLVFLLDRIDTGVSGKDLLVSFRTGEAENALRANMITAHLSDHPSLCRQGLSALHHCRAVCLQNGLSIIRPAMSISVTDPKGRFSPGDYLSLSLFYRQKIAQVHIMGRFAELGAVFDGISQALRFVRDYFQKSRTAFVAEHLQDRRDILELPVTREQHAAILEKLSSVQRGIVEAPAEKNMLVVAGPGSGKTRVIVHRMAYLIKVLKVRPYRILAVAFNRSAVAEMRRRLKDLLGKSGAGVKIHTYHSMAMSITGHSLAGKGGDTSVFQGILQEAVDYLDGTSTQEDGSALHWRDRLLGIQHILVDEYQDINDLEYQLISLLAGRNEDEQSPRPSMLAVGDADQNIYSFQGANVRFIQRFAQEYQAEIVHMVHNYRSLPPVTLAANALIRHNQDRMNTPPVEAVRKDKAEPVGMIMAGSREAMLKAALDQARRLMVQDGLSPEDICILCRTNQEVFALANLARHAGMELSLMRRRNISLPLVREVHEIMDLLMRCPGSLCTGSEVYDLVMHLMVESSARSRLWLYHLEIMARDYRDECGSMRRPVYEFCEHVWDSSRDLRRMESRSPGALRAGTMHGAKGLEFPAVILAGTPGDRESPEEERRLYYVGMTRARDRLVLCCGPDHPFAPEILAAGPEAVSRISCDIALTPVEQNLAREELWEMSPEHVILSYPAWDNIHGETTAAIDALQDNPGKEFTFLPWANRYLVCTAGVPVTALSDRGSRIYENYLSRGFRVKQVIFLAALHRKASQEDQTLKELRCSSWYVPLFQVVWSRCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMM5</accession>
    <name>D6SMM5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869064.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3378"/>
    <dbReference type="EnsemblBacteria" id="EFI35936">
        <property type="protein sequence ID" value="EFI35936"/>
        <property type="gene ID" value="Dthio_PD3378"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="295"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="327"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="604" mass="68589" checksum="70414DD0972350DA" modified="2010-08-10" version="1">MSSTPLISCHGIKKAYSGRELFSELSLGFFPQERTGLIGPNGSGKSTLLKILAGMETPDSGELTVRRDTRLVYLPQTENFDRDQTVEQALMQVMESVDHDPESYVSLKKTAGQMGFFHLDTMVCTLSGGWLKRLSMARALLQEPDLLLLDEPTNHLDLEGILWLENVLKNPDFAFVLVSHDRAFLENVTNRIVELSRIYPEGCLRVEGSYSTFLEKRQEFTQSREKLEQRLASKTRREIEWLRQGPKARTTKAKHRKETALALQEELSQVRSRNAGNRAAEIEFSGTGRKTRKLLRCRNVSCKRQGRTLLEGLDLTLSPGNRLGIVGRNGTGKSSLLEILSGEMEPHSGTVQWAEGLKVVHFDQNREQLNQEQSLQESLCPSGDQVVYQGRALHVVSWARRMRFDPDQLPLPVSRLSGGEQSRLLIARLMLKPADVLLLDEPTNDIDIPTLEILEQSLEEFPGAIVLISHDRMFLDNLCDRLLYLDGQGRATFVADYVQYIREAAQTDKPEQKVQSGKKAKPRPRQQNKMSFKDQREYESIEGDIERAENEVAGLKEKMNRPEVMSDAKELERLCSELEQAEAALMRLYARWEELEEMAAKCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMN6</accession>
    <name>D6SMN6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869075.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3389"/>
    <dbReference type="EnsemblBacteria" id="EFI35947">
        <property type="protein sequence ID" value="EFI35947"/>
        <property type="gene ID" value="Dthio_PD3389"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1670015at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="249" mass="28153" checksum="9EAF52194AACBE4E" modified="2010-08-10" version="1">MIIYSSRELRENFHQLGPGDACVGHLSFSPGEEYKVVDLMHRGINFYPSLLSAFLSRSKVLQAEVLSQFMLPDTFVAYRSIDLCRNQAAYTRYGSVVSKRDRKHLGMGVGRWSSLEELQRLDSLGALPFPLVIQPFLEEARDFRVVIIDDHAEAYERINPYSYRKNLAQCGTASPVHMDSTLLAFCTNVMQRGDFPYALLDILQSPAGDLYLAEISLMGGLSGSSIGHEGFLQRKKLLQEKFCRRFEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMS9</accession>
    <name>D6SMS9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein, family 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869118.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3432"/>
    <dbReference type="EnsemblBacteria" id="EFI35990">
        <property type="protein sequence ID" value="EFI35990"/>
        <property type="gene ID" value="Dthio_PD3432"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="359" mass="40725" checksum="26C9D898D5D55CD1" modified="2010-08-10" version="1">MKGRLYYWIWLLLILFFPVVFGCAADEEMDDAEKPEETFSLSLATFWPATDFMVADAHKRWIEEVEKRTDGRVSINLHAGEALLGAREIYNGVAGGVADIGTTCPSYTPGMFPLMEAFELPGYQNVNAVSASMTAHEGYKRIKQDLGIDEFEDVKVLFFWATGPGDIMSQKPARNLDELAGMEIRAVGGTVPPLEKLGAVTHSMPMSESYLALDQGLVDGIVAPNDTLKGFRLAEVVDYVTHTPFLYNVVFMKIMNKGTWNSLPPDIQDVFREMNDEFAYEYGKSRADHRQEGLEYGMQEHGIEFFELDADEEQKWLDRIQPVVEDWIKKQENRGLPAEKTVELIRELDEKFSAEYPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMW4</accession>
    <name>D6SMW4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869153.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3467"/>
    <dbReference type="EnsemblBacteria" id="EFI36025">
        <property type="protein sequence ID" value="EFI36025"/>
        <property type="gene ID" value="Dthio_PD3467"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1580474at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="33537" checksum="FA1D94CC312B5590" modified="2010-08-10" version="1">MADTEKKVPDNGRAGAPEEEKSRIQGVFSTQNLVKVGTGSTQKKTVQKMYWYVNQLDDENVEIQPLNVNYVPSGPKKIVPRDEILEKFSPEPEFYTYTVFPKMRELNKTIARGDRHRKKGESYSAEFEYNNALKVDIENIRANFGLGLTYLERGEKEKAQDIFERLVKLDAAFEDEHKHLFNEFGINLRKQKMYQQALEYYTKALDMVENDENLHYNVARAYFEFKKYDKTFEHLLETLKLNPEMEHAKKFIMYMKKHNMLPQDADAKIKQALGKKSRQEPAEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN00</accession>
    <name>D6SN00_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">KWG Leptospira repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869189.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3505"/>
    <dbReference type="EnsemblBacteria" id="EFI36061">
        <property type="protein sequence ID" value="EFI36061"/>
        <property type="gene ID" value="Dthio_PD3505"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951208at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="323" mass="36781" checksum="0A7E72C227783CAE" modified="2010-08-10" version="1">MRYQVNLFPLLENKWGYINDKGEWVINPKYDHALPFSQGLAIVRYNNNNFVIDESGTILNQRGFDEAYGFSCDRCAVRIDKHWGYIDTDMNFVVKPKFSVASYFSDFLALVDIIDYDDALNQYGYIDYSGDFRIMPTFDFAFDFQEGLAQVEKESRDGTVKGYIDSEGNLKIDLSDAPEISGMRSFSEGLASLMWGDYCGCIDKSGQWQIDPRYEFIGEFSGGLAKFREKDKWGYIDHSGKTVIQAHFDFASDFSEGFAVIGMGSLLQRTLKKGYIDLSGRIVVEPKYDIANPFYQGLAYVGITDGCRGYIDQNENFVKKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN58</accession>
    <name>D6SN58_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869514.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34184">
        <property type="protein sequence ID" value="EFI34184"/>
        <property type="gene ID" value="Dthio_PD1532"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="264" mass="30966" checksum="365F51E59630B12D" modified="2010-08-10" version="1">MPRANRYFLPDHLWHITHRCHKKEFLLKFAKDRSTWIKWLFEAKKRYGLQVLNYTVTSNHIHLLVHGHEDKDVIPRSLQLVAGRTGQEYNQRKKRKGAFWEDRYHATAVDVDEHLVKCLVYIDMNMVRARVVKHPKEWSHGGYPEIVKPQQRYRIISRDLLKRLLDIDDDLSKVYSGWVQAAVDERTPRQPGWTESVAVGCKVFVEKIKELLGGKACGRRVHEVDKTGSYALKEPVSAYNDVFGGEMGLLRSENRLFWDIYPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN78</accession>
    <name>D6SN78_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cycloinulo-oligosaccharide fructanotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869532.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1555"/>
    <dbReference type="EnsemblBacteria" id="EFI34204">
        <property type="protein sequence ID" value="EFI34204"/>
        <property type="gene ID" value="Dthio_PD1555"/>
    </dbReference>
    <dbReference type="OrthoDB" id="697026at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030916">
        <property type="entry name" value="ELWxxDGT_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04534">
        <property type="entry name" value="ELWxxDGT_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8115" checksum="526B241B073FAAF6" modified="2010-08-10" version="1">MPSSANYKQDPVDKSQTDALVSQSDSIAQHSKVDSGQTGVSSGRVVFAAYDSGYGRELWISDGTYEGTGLLKDIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN86</accession>
    <name>D6SN86_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869540.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1563"/>
    <dbReference type="EnsemblBacteria" id="EFI34212">
        <property type="protein sequence ID" value="EFI34212"/>
        <property type="gene ID" value="Dthio_PD1563"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="PTHR40036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05711">
        <property type="entry name" value="TylF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="285" mass="32956" checksum="0A22AB58A0237B86" modified="2010-08-10" version="1">MFGFLKKKLLSKSAYSEKELISAILKQISDKKLKSLLRIYRKGKLDPKRFRSAMVLYNRATYLEDLLGTKANATFLEDSRFKEAYQAAASVSTWGRDIRWRVYNLIKFAGVALRLEGEFVECGVDRGGMSLALLTYYPEDLPYRRFWLFDTFQGLVYEQMNEMEREKSPFLKERNKDRYPPIYEEVCRTFSGYENINIIPGMVPETLEQFSGQKVAFLHIDMNVAYPEVKALEFFWPYLVPGGVVVLDDYGFPLHTEQKHAMDACVSRLGTDIILQPTGQGLIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNB0</accession>
    <name>D6SNB0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HipA N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HipA Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869564.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1587"/>
    <dbReference type="EnsemblBacteria" id="EFI34236">
        <property type="protein sequence ID" value="EFI34236"/>
        <property type="gene ID" value="Dthio_PD1587"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1293681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012893">
        <property type="entry name" value="HipA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017508">
        <property type="entry name" value="HipA_N1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13657">
        <property type="entry name" value="Couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07804">
        <property type="entry name" value="HipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03071">
        <property type="entry name" value="couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Couple_hipA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HipA_C" evidence="3">
        <location>
            <begin position="146"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="416" mass="46578" checksum="841252D7ECE6DAA1" modified="2010-08-10" version="1">MDESLLVYFNETLTGKLWLGENRTYHFRYFPEWLRDPHSIPLSVSLPLQDVTNSGDAVKFFFANILPEGSVRDRVAAKLGLSTENIFSLLRELGGDCAGAISLYPEGALLPERQKAYRKLSALELEKIAADLPKRPLLAGEDGLRLSLAGAQDKLPLRFDGKSFYLPVGGAPSTHIFKPSIPHLKRTVFNEAFCMALARASGLPAPECTVLNLGSNHALLVARYDRLVDYEEIRRVHQEDFCQALGQSPEIKYEAEGGPGLKDCSDLLRRHSASPARDLMLLLRWTLFNVLLGNADAHAKNLSLLYDQGKAPRLAPFYDLISTLMYQELSRKLAMKIGGENRPEWLMNRHWCRMAEELDLKPKFVLDELGLFCQAVREAVDPALEGFAEHSSAHTFLGKLAGAVKDRTERNMKEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNC0</accession>
    <name>D6SNC0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869574.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34246">
        <property type="protein sequence ID" value="EFI34246"/>
        <property type="gene ID" value="Dthio_PD1597"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZGFC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077740at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="7753" checksum="93BCB010B761B654" modified="2010-08-10" version="1">MHVFADGISKVTLSNGNLRINLTQRGADNESVDAGTLIVPASQANNFLNGLAGSLKDLDEKLKAQREAQGETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNF6</accession>
    <name>D6SNF6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiE</name>
        <name evidence="12" type="ORF">Dthio_PD1633</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869610.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1633"/>
    <dbReference type="EnsemblBacteria" id="EFI34282">
        <property type="protein sequence ID" value="EFI34282"/>
        <property type="gene ID" value="Dthio_PD1633"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="214" mass="23133" checksum="763647029C098B84" modified="2010-08-10" version="1">MTKEIDYSLYLVTDNGLCMGRDLTRVVLDAVQGGVSMVQIREKNSTAGEFLNTARALQQRLSDSGVPLIINDRVDVAMAAGAHGVHIGQEDLPYQVVREMLGPDKIIGVSINTYDQLWQASLTDVDYLSLSPVFPTQTKTDTKEPFGLEGLKKARAMTGKPLITIGGINRDNLADIMATGVDGVALVSAVCSADSPADAARELVRIIRDNKMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNJ0</accession>
    <name>D6SNJ0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PBP_domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869644.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1667"/>
    <dbReference type="EnsemblBacteria" id="EFI34316">
        <property type="protein sequence ID" value="EFI34316"/>
        <property type="gene ID" value="Dthio_PD1667"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2998">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087897" description="PBP_domain domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="33"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="284" mass="31235" checksum="C126E75903722A3D" modified="2010-08-10" version="1">MVRISLFLLLAALLGVSGCHGDQVQDRDRVLTMSTTTSTEASGLLDHLLPEFKADTGITVRVMSKGTGAALRDGMDVNADVVMVHDVERENQFVEDGYGTKRYYVMYNDFIIVGPEEDPAGIEDAADIAEAMRLIADAGEPFVSRGDDSGTHGREKQLWEESGLEITGSSEPADGAGWYFSIGQGMGQALLFAEEKNGYVLADRGTYLQYKYGRDAQYDLEIVYEGGDMLENPYGVIPVNPEKHPHVKYDLAKEFAEWLVSERGQEVIGSYELLGSQLFIPDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNL9</accession>
    <name>D6SNL9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1696"/>
    <dbReference type="EnsemblBacteria" id="EFI34345">
        <property type="protein sequence ID" value="EFI34345"/>
        <property type="gene ID" value="Dthio_PD1696"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="62"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="280" mass="31429" checksum="62450402D0850F8A" modified="2010-08-10" version="1">MPDNIHPMPILAFTADYSDSASRLERAAKASHGLEFSPDPLRPDLLPGSVLPFLRRDIPVRFHTRYFGWEMGHADRHEAEKALQVHLETIKKMHGLGEPVVTVHTGLGPAVPIRESHIRDNLSKLVEFAGKKGITVCLENLRLGHGSDPYKILEWAKASGAMITMDTGHARGCSMVRDNLITPADMVDLFGSSLYEVHVYGREDHLGHHPIKDIAPLQEMLTRLLQTDCKWWTIELQDLHLATSSRSILERFLGRNVTGTSLDYAPGKPAEQDPEHYERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP46</accession>
    <name>D6SP46_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34522">
        <property type="protein sequence ID" value="EFI34522"/>
        <property type="gene ID" value="Dthio_PD1889"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026354">
        <property type="entry name" value="4helix_suffix_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04258">
        <property type="entry name" value="4helix_suffix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="217" mass="24736" checksum="E7015186670E5D6D" modified="2010-08-10" version="1">MLLTESETLIPKHGGYRKLKSFQLAQLVYDLTVRFCGRYIDKRSRTHDQMVQAARSGVQNIAEGSEVSATSKKMELKLTQVARASLEELKLDYEDFLRQHDLPCWDRNHPLRQDLVDAQCRSVDDVAEWVMNAAKKIAWERGHSEQSRLGESDKDIESSTFTASSFYPEISANAALTLATVAGYLLDRQIQALAESFEKEGGFTERLYSVRTARRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPC1</accession>
    <name>D6SPC1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869917.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1969"/>
    <dbReference type="EnsemblBacteria" id="EFI34597">
        <property type="protein sequence ID" value="EFI34597"/>
        <property type="gene ID" value="Dthio_PD1969"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200399at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="67"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="375" mass="41667" checksum="CE56E706D45A7D1A" modified="2010-08-10" version="1">MKTVPGLRKKNSFVSLAFLAALTLLSWPGLDLNTPAAQEPDVFEAKKFQVTNYYQAAGTIRPWQEPVLSAQVQARVKEVLVAPGDMVESGDLLIRLEQDEFKSRLEQARLDLEGAQASIQRIRREIDEAGALLEETGPQFERMKRLHGQDVATQQELDQAASKYFQARAGHEQALMALQEAAYSRDALQEKISELQVVLDYTSIRAPARAQVVRKMVDAGDLAAPDKPLLKLQTRHLLRLEAHVPERLISRVSLGDVFDIRVDALDKKISGRAAEIDPAADADSRSFLVKLGIEAGPDLYPGMFARMLIPVETEEMLMVPESAVRMIGQLATVQVVENQQKQTRHVRLGRTVNQRVEVLSGLSAGEKVKLQHLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPD0</accession>
    <name>D6SPD0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the P(II) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869926.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1978"/>
    <dbReference type="EnsemblBacteria" id="EFI34606">
        <property type="protein sequence ID" value="EFI34606"/>
        <property type="gene ID" value="Dthio_PD1978"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2021322at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12300" checksum="D698556FDA903946" modified="2010-08-10" version="1">MKKLEIITRPFKVEAVKEALAGMGIKGMTLTDVKGFGRQMGHKEIYRGAEYDVDFLPKVKIEVILDDANVDQAVEAAIKAARTDKVGDGKIFVYSVENAIRIRTGESGDEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPG4</accession>
    <name>D6SPG4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">Dthio_PD2012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869960.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2012"/>
    <dbReference type="EnsemblBacteria" id="EFI34640">
        <property type="protein sequence ID" value="EFI34640"/>
        <property type="gene ID" value="Dthio_PD2012"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="262" mass="27837" checksum="115E2E8C40B29350" modified="2010-08-10" version="1">MSLYKCLLVDAGNSSIKLALAGKKGLGPSFELPTDIRETSDSLGLKILAFFEQEQVKPQDIHAWLAASVVPRLNPVIKRAGKKICSSEVYQVPGDLHPDINNRYQNPGELGADRLVSAFAARRIYPGEGIIVVDFGTATTFDCIIKKDYSGGLICPGIFSSVQSLSTLTARLPWFSTEEAGDTLEICRSTTRGLAQGTVFGLAAMTDGLISGLKELMPADTMAVATGGGAAAVTPFCTSVDKIHPALLLQGLMFTAIDSKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPK3</accession>
    <name>D6SPK3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2051"/>
    <dbReference type="EnsemblBacteria" id="EFI34679">
        <property type="protein sequence ID" value="EFI34679"/>
        <property type="gene ID" value="Dthio_PD2051"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="179" mass="20342" checksum="4B9BA03328591209" modified="2010-08-10" version="1">MEKLDAAAGDKPAGSWSGQAMHGTDGSRIKELLSQVKMPNPIFQLFAGASWEGMPELVPFEDSDRWKRLKNHVVTYLERNLEELTSLEDLSTFHAFEKLSAFRSSNLLNFSEPVPDAYTCVDTSRRYCENPGGSCQRFFLKSYCKKHHRPEHKTPGTPCLHGYFTAADRLDIITRRTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPM2</accession>
    <name>D6SPM2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870018.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34698">
        <property type="protein sequence ID" value="EFI34698"/>
        <property type="gene ID" value="Dthio_PD2070"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC34">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="603965at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="48749" checksum="4A492BF3DD30D1C7" modified="2010-08-10" version="1">MDKYFSFLDNQINDLLRVDIGFSTCPAADIYPLQPEVMQGYQKRHELIQKFQDITSDLFLASLAQEADPAIAGLIINELPQSFGWNWHRELHERAREMEISLQPAFFRTDEVVPGKISEIQSPGSLWCQCEQLYSFYEHFSQDFKGKPVFPGSMAGQFARDLKKHLDDQPLVHHLLDNASVQSGMRFFLQRTRDHGVRYFGYDKDVSAYDCNFIRAHAFHGLMSDNYFKTRFDAWQNKRLHYDLPPSIVFDEKIPLIFPFWEKTRDMYPDEIREIFPYTTLVDPENIVLEDGEHMDIHEFFQLPRKRRDYFLKYAGCDLDANWGSKGVYSMQAMTGNTAERIESLLTEGYKHNRYWILQKSYSVKEDIAYLDRSSGLQETTATAKYSGFYGPSGLMGILVMHRPFYKVHGAGDTIVSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPS9</accession>
    <name>D6SPS9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR_Cas6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870073.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2131"/>
    <dbReference type="EnsemblBacteria" id="EFI34755">
        <property type="protein sequence ID" value="EFI34755"/>
        <property type="gene ID" value="Dthio_PD2131"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1828479at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="1">
        <location>
            <begin position="205"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="334" mass="37653" checksum="DF40F1D7287C4873" modified="2010-08-10" version="1">MLENNHLEQLRIMTSGLHVLELEFTAVFRISGNLGDKKGEKVYLPQVLRGGWGHKFKEVCCDQEQWREVHSCPDECQCAYGTIFCSRPGNLLSSLGSGQQIPRAYRVSAPFISNRVDAGQVFRFHFNLYGKAIQAWEPCAAAWMQLSESGIGVNNRIPFQITSIVNKSDSNRLIWTMDQPDRIYPPESAVIETGAGRRAEMVHINFTSPSLFAVQNLGKKLPPWKLNPAQLAQTAINRIARLAEIWGENRVEPIRLDYNSDKQPRLMRYRQTGKMTDQRSSQQEKNRQQISGWTGNLLFRGDAGMFAEVMELAAPLGIGQNTTAGFGSYQVYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPW4</accession>
    <name>D6SPW4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870106.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2167"/>
    <dbReference type="EnsemblBacteria" id="EFI34790">
        <property type="protein sequence ID" value="EFI34790"/>
        <property type="gene ID" value="Dthio_PD2167"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="118" mass="13529" checksum="BCDECE4B408424B2" modified="2010-08-10" version="1">METPFGLYVREKRLELRKIDKKYSLRQVAGRISVEPSYLSRIERGWPVPLSEAKIISLAGDLGENPDLLLALAGKVSSEVQEVIRSRPEFFAELIKNLKNMPDHAVLRLVREVRDGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ10</accession>
    <name>D6SQ10_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2227"/>
    <dbReference type="EnsemblBacteria" id="EFI34836">
        <property type="protein sequence ID" value="EFI34836"/>
        <property type="gene ID" value="Dthio_PD2227"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="34"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="291" mass="32329" checksum="02F5F723CF872392" modified="2010-08-10" version="1">MAMPDAQTDMSPAGEAVQDKPGHTGDRTSAPALVQVKNLKVYFPVYGGLFRRVRGYMRAVDDVGFSVPEGSTVGLVGESGSGKTTTGRSMVRLIQPTAGEILYRGSDVVGLSKREFFPYRKKMQMIFQDPFNSLNPRMSVEKILTEPLGIHFPRMSADERHMRCARLMEMVGLKPDQLRRYPHEFSGGQRQRIGIARALAVEPEFIICDEPVSALDVSVQATIINLLQDLQEELGLTYLFIAHDLAVVEHISDYVLVMHQGRIVEQASSEVIYSAPQHPYTIKLLQAVPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ89</accession>
    <name>D6SQ89_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870229.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2306"/>
    <dbReference type="EnsemblBacteria" id="EFI34915">
        <property type="protein sequence ID" value="EFI34915"/>
        <property type="gene ID" value="Dthio_PD2306"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50335GW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1789183at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="13168" checksum="E094CE011A0C06B7" modified="2010-08-10" version="1">MSYDIQLVKLVNGDMVLGKWNAQENKITDPAILQMIPTQQGGVQMMLLPFGYPIENEVTGEIEGRHIIYFYKKIPEELKSKYMEASSNLTLSGANDLKNLGGMGGGGGQNVTDLGSLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQG2</accession>
    <name>D6SQG2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">Dthio_PD2380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870302.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2380"/>
    <dbReference type="EnsemblBacteria" id="EFI34988">
        <property type="protein sequence ID" value="EFI34988"/>
        <property type="gene ID" value="Dthio_PD2380"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="6"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="209"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="35390" checksum="BD40DBF37B28266B" modified="2010-08-10" version="1">MAGKQKRIVFMGTPEFARIVLEKLLQWPGGAVVGVYCQPDRPSGRGRRLSFSPVKELALDRCLPVLQPPNFKSLEEVEKLADFRPDYLVVAAYGLILPSAVLDTASEMPINVHASLLPLYRGAAPIQRAIIEGRSRTGISIMRLTPGMDEGPVLMEESLAIEEQDTAQSLHDKLALLGGDLVVKTLEALKHGKIDPVPQDHDQATYAAKLTKEEGRIIWDRPAKEIHDQIRGMYPWPGAYFDWTSPSGKTIRLKVYPGRVGGDRPPEINPGTVAGLEDEHLAIACRDKMYLTDRVKPENSREMSARSFYCGFMQQCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQL2</accession>
    <name>D6SQL2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2432"/>
    <dbReference type="EnsemblBacteria" id="EFI35038">
        <property type="protein sequence ID" value="EFI35038"/>
        <property type="gene ID" value="Dthio_PD2432"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="713168at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="47918" checksum="5EE9AE27F12CB81E" modified="2010-08-10" version="1">MFRHENIFYMLWDESHLWGLMLWRALKDLEIPARIVSSQDIRGEILSTRPPAGLLVPGGWARLKADSLGLAGMSSIRDYISAGGKYLGICGGAGMGLSSASGSPCLDLCHWSRKPMQDRLPNFSGHVRCRVRLPHWKESRRDICLPVWWPSQFEPGDNASDGVRALAEYLEPDQDFWTADLPYSDLKQADICKWEKVYGINLDPGLLRSEPCILHGTMGSGEFVLSYSHLETPQSRQANRLLRELLFTWLGWNIPREVKTRVSSWDLKNIEPVWEDDVLMRCRQGLEEIIELGRAHFLFYWRTPWLLGWRRGVPGSPVNFLYAMAGHAQGQRPGRKAQEFWKGEKESFARHLDSFLSRLKTYLTRERLAMSLAPSSPEASSDLDLQQEKLELFGSFPGYGGLYGRLIQPLDHLLYLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQM9</accession>
    <name>D6SQM9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c-type biogenesis protein CcmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CcmB/CycW/HelB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2449"/>
    <dbReference type="EnsemblBacteria" id="EFI35055">
        <property type="protein sequence ID" value="EFI35055"/>
        <property type="gene ID" value="Dthio_PD2449"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003544">
        <property type="entry name" value="Cyt_c_biogenesis_CcmB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03379">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="224" mass="23581" checksum="A2A2695EC1CE7E10" modified="2010-08-10" version="1">MTSRPLALMAKDLRLVFADGAGIVQPVLLGLILVFVFSLSTPVGEDVSPQAAAAIFWLATSFAVILVFNTLYSSEGANQSRIGLLLAPMPIQYIWMGKALAGGVLLLMAQAVFLPAIVVFLGQDQVVSWPGGIGSILLVDWGLVAVGSLLGAMSQGHSARDSLLSVVIFPLLIPVLLAGISMGSYFLGDGSGDDLRSWMGLVLAFNAMFTGAALLLFPFIYGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR97</accession>
    <name>D6SR97_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870571.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0539"/>
    <dbReference type="EnsemblBacteria" id="EFI33213">
        <property type="protein sequence ID" value="EFI33213"/>
        <property type="gene ID" value="Dthio_PD0539"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023807">
        <property type="entry name" value="Peptide_mod_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04082">
        <property type="entry name" value="rSAM_for_selen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="207"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="535" mass="60119" checksum="CB3CAAD3AD0DE936" modified="2010-08-10" version="1">MQPNETNLENIFPACKSLVTRQAWSALVARMDTKPGPEKFPAMISSLSHKLELPEYLAELAELETALYSCLQLADQVPSSVHQKMINPSLKMLELHWKGLDKALERAGDPKIQPASQPELMLVWFDPASGCSRAQPADHRTLTALKIVSEDQPMGSTALEYKVNLAELHRAVDQSASRGLILAPRTRLGRDPAIFQPHDKSFERFMHPRVFTLQWHITQVCDLNCKHCYDRSSRSPMSLESAYYVLDELEKFCTHNNVRAKVTFTGGNPLLYPHFDQLYLETVRRGFPVNILGNPASRQRLEQLLEIQTPSMYQVSLEGLREHNDFVRQPGYFDRIMEFLPLLRELGISSQVMLTLTRDNMDQVLPLGEHLRDMTDLFTFNRLSAVGEGASLLMPSYAGYESFLHEYIRATRDNPVLGLKDNLINSIRDENGHKPFGGCTGFGCGAGFNFATLLSDGELHACRKFPSPLGNIFQNGLIQSYESEAGRKYRAGSEACRDCRLLPACGGCQAVIYSLGLDPHKDRDPYCFYSNAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRE6</accession>
    <name>D6SRE6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870620.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0588"/>
    <dbReference type="EnsemblBacteria" id="EFI33262">
        <property type="protein sequence ID" value="EFI33262"/>
        <property type="gene ID" value="Dthio_PD0588"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="24527" checksum="3D64E60FCA5967F7" modified="2010-08-10" version="1">MIDLHTHTVYSDGGLIPAELARRARAAGYRGLAFTDHVDDSNLRHILESQQKVVRDYCLYTEIELLGGVELTHVPPPLMETVVKSARDLGAEIVLVHGETIVEPVVQGTNHAAIRAGADVLAHPGLITPEDVRMAAEKGVYLEITTRKGHSLTNGHVLNLARIYGAKLVINNDAHGPEDLVSREMRQKIALGAGMDMQEYEQAEQNSLDLLSRLRKSGNTGGSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRG4</accession>
    <name>D6SRG4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, MucR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ros/MucR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870638.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0606"/>
    <dbReference type="EnsemblBacteria" id="EFI33280">
        <property type="protein sequence ID" value="EFI33280"/>
        <property type="gene ID" value="Dthio_PD0606"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1797085at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041920">
        <property type="entry name" value="ROS/MUCR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008807">
        <property type="entry name" value="ROS_MUCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05443">
        <property type="entry name" value="ROS_MUCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15623" checksum="75A06046A2020AB2" modified="2010-08-10" version="1">MEDHVKQALEIVKAQAAVRNMTEEEINSMIKSLSAGIQEASKTDELQEKDSQEPSVDPKKAIKEKSITCLECGKSFKVLTKKHFAKHDMTPEEYKAKWGYKKNQSLVAKSLARERRKKMQDMELWKKREIKMPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS16</accession>
    <name>D6SS16_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870834.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0816"/>
    <dbReference type="EnsemblBacteria" id="EFI33482">
        <property type="protein sequence ID" value="EFI33482"/>
        <property type="gene ID" value="Dthio_PD0816"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="246" mass="26722" checksum="E8CE781C62BC5EA2" modified="2010-08-10" version="1">MHAQNKPRTALVTGGSRGIGAATAIMLARDGFDIWLNYRSNHQKASVVKDSIEILGRKCQLLPFDVADPEAAFLALEPVLEKETPFAVINNAGYAADKLMLTMDYHDDWRKVLDVHLDGFFLVTKLALEKMLRKRSGRIVNIVSTAGQSGMPGQTNYAAAKSGLIGATKSLAQEMGKRNILVNAVAPGFIETDMTTDLPWKEMLPRVPLNRIGQPEEVAGAVSFLCSDKASYITGQVIAVNGGIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS24</accession>
    <name>D6SS24_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucan phosphorylase</fullName>
            <ecNumber evidence="6">2.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870842.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0824"/>
    <dbReference type="EnsemblBacteria" id="EFI33490">
        <property type="protein sequence ID" value="EFI33490"/>
        <property type="gene ID" value="Dthio_PD0824"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="137158at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="5">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="853" mass="98262" checksum="4C5D23A6CAEA3AE7" modified="2010-08-10" version="1">MRPLKVYNVIPRLPGELAPLWELAFNFWFSWKHEISELFSRIDYQLWHKSGQNPVKFLNLLPKETLEDLAGDEFFRDRLHQVKASLDNYKASTKTSFEFEKSGGEPVVAYFSAEYGISLSLPIYSGGLGVLAGDHLKSASDLNLPLVAVGMCYQNGYFRQYLTNDGWQQERYPVNDFEQMPLTLVRNKDGSPLTVQVDLVERKVSMRVWKANIGRIDLYLLDTNISENEPQDREITAQLYGGDWEMRIKQEIVLGIGGLRAMHAMDLNPRVIHMNEGHSAFAGLERIKLFMQDHGMSFEAATELVASSSVFTTHTPVPAGNDRFAPDLMHKYFEPYARELGLAFKVFMALGREDPRDDQEHFCMTVLALRLSRFNNGVSQLHGTVSRNMWKKVWPQYPVDDVPIGAITNGIHITTWIAPDMSYLFDRYLGSDWREDPDCQRVWKQSQAIPDSELWRTHERLRERLVDYVRYRLKEQTVARGGRRSELHLAEEALDPSALTIGFARRFATYKRANLLLTDVKRLLEIVNHEKYPVQFIFAGKAHPKDVEGKKIIQQIVQHAREADLSHRLVFLEDYDMEIASYMLQGCDVWLNNPKRPLEACGTSGMKAVANGVLNFSTLDGWWDEAYTTDNRYGWAIGMGESYSDQEYQDLVESHYLYNVLEKEIVPTFYDRRHGSLPTEWVRKMKNGLRDLAPQFSSHRMVEDYVETAYLPAYKNFMALEKNNFEKAKSLADWRMELMTKWGSVQIRNVRAAAEDELYAGDEITVSAEIDVNGLSTEDIQVEIYAGDVDMDGSFLSRKTVLMQQKKKLDDGWILYEGKLETFETGRFGYTVRILPYHSLLLDPHCLGLIHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS57</accession>
    <name>D6SS57_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870873.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0857"/>
    <dbReference type="EnsemblBacteria" id="EFI33523">
        <property type="protein sequence ID" value="EFI33523"/>
        <property type="gene ID" value="Dthio_PD0857"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="211" mass="23838" checksum="E6DF5ED73B0FE4C3" modified="2010-08-10" version="1">MSGKEDPASAWLRWAREIQAISGIGLLFSKNHHDEKNFSRLQEIAAEMAEMHSNMDYTRAMNIFQDQSGYVTVKVDVRGAVIQDGRIMLVKEIKDGLWCLPGGWADVGETPSEMVAREVWEESGYNVVPERLVGVYDANRGGRPISFFHAYKIVFMCRITGGHARTSPETSAVDFFDFDDLPVLSSNRTNERHLEHVRACLMDPQRPAAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS77</accession>
    <name>D6SS77_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PP-loop domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870893.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0877"/>
    <dbReference type="EnsemblBacteria" id="EFI33543">
        <property type="protein sequence ID" value="EFI33543"/>
        <property type="gene ID" value="Dthio_PD0877"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1051352at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="50"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="299" mass="33890" checksum="44ABBA989C26241C" modified="2010-08-10" version="1">MKCTRCKKIAAVALPSHNAGFCPECFKVFFSRQVEKAIKERTLFSKEDRILIALSGGKDSLALARELHLLGYNTAGLYIDLAIPGSSETARDHVERFCRDLGISLHVLEMEKEGMPIPEVRKKFNRPVCSVCGRIKRYYFNRFALDNGFSVLATGHNLDDEAARLFSNVMRWDVSYLGSQGPDLPAEQGFVRKVKPLYRLSEFETANYSFLAGIDYCYAPCPYSKGASFTYYKYLLDELEHEQPGRKISFYEGFLNRGRQAFDHIDQEGGEKPGPCPRCGYPTTGDICGVCRIREVMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSA0</accession>
    <name>D6SSA0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870916.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33566">
        <property type="protein sequence ID" value="EFI33566"/>
        <property type="gene ID" value="Dthio_PD0900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZX9M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2120015at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="654" mass="77571" checksum="A7899D7A8AFAD3CB" modified="2010-08-10" version="1">MKRSVKEKQISIFLHALFESSDIAPAFKKNLNPIKILTHIYLYKTGCADIAKKIKFDSLPATKNNERHMVNKICNFFKDSDPHQKNDVASYLVQNYPDEVDCLCPDFILTKIRAIIKKINKNDLHEDHVEKLVWEHICDKKIYHKFLDNILLFIEDRSIENNNLAKFLTTKKADLKENTFYKWIIRQNFIQKLDYAELGLAHSAKMAEFVDQDKMLGTICFLDFATEDLKQKFHHMLVKKYKTSKMSDMFLELFSESRQKNELFGKAVVIFGFFIIMFKFDDFVDFYQTTMVPDDHRNDWTNYSYKDYCYKILEGFQSGIKSDYVSSHFRLSTLKDQDTMQKISFVFWKNTFLKEKIKHECCPVQSAQNKKIHKYKSITKDKINDRRLLKIIEHLFSKKINISVYSFKSNDPYINLECTPLKMENDGFLIFYNNKDLEFKMDSIPFSVKCRFHVFDDSLNKRYYVFETELMHVFPADDHNILKLNYPVEYNLSDRRLDRYIPAPSDIYTLSIWEANNEQPEMTIQKPPLCRNFKQDSMKILNISSGGIRLSFKTHHLEKIEHEFALQQAYIFKITLSYHDKPADIYLTAVVRNLNWFHEPEPEIEVGFQFIQEAFFSSNKKISWSDITKKGSWHIGSWIFGNNMEKCKDFSVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSA2</accession>
    <name>D6SSA2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase U32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0902"/>
    <dbReference type="EnsemblBacteria" id="EFI33568">
        <property type="protein sequence ID" value="EFI33568"/>
        <property type="gene ID" value="Dthio_PD0902"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="712" mass="79157" checksum="59D4D2A85B674EED" modified="2010-08-10" version="1">MAVGVGKISAGLSPGLVPAINTEKPLNGYAYSVLFAGSNTCGHGYFAVIRSVTGRLRHCLKPFNPPFTMTRPEILAPAGQEASFLAALAAGADAIYCGLKHFSARAEADNFSLSRLAALRQLAGEQNVRVYVALNTLIKPQELDKAGRLLDRLQRFVQPDAVIFSDPGLVDIARQAGLECELHLSTLGALTSRTGQRRLADMGVSRAVLPRELDIDEIRKTADKSPLQLEVFVHGALCYGVSGRCWWSSYLGGKSGLRGRCVQPCRRSYDYKGQRGNYFSCLDLELDVLVKTLLTVPNLSAWKIEGRKKGAHYVFYTTTAYRLLRDNPDDADTKKEAQGLLEQALGRKSTHYNFLPQRPFVPLSPAREPGSGRHLGVVKGSRSKSYINPAIQLLPGDLVRVGQEGETGHKLIKIKKTVPGKGRFDLPGSCRPGLPAFLIDRQETELTGLIQDLESKIIDPEIRPGASRFIYQLPAPLKKKSARALNLEVFRFAPRKKGPLGIHLSLDPQRGVISGPLRDNWYFLPPVIWPREEEEWQEIITGLQKKGARNFVLGSVWQVDMFKTPEKLNLWAGPYANIANPAALKILQELGFKGAVLSPELSREDFMQMAHKACIQVGIVIKGLWPVSISRTFAAEARPFLPFISPKKETFWAAKRDANIYIYPNWEINLTEFESDLRRAGFSLLLHLKEPLPRKITLKDRPGLWNWEQGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSD2</accession>
    <name>D6SSD2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="17" type="ORF">Dthio_PD0933</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870948.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0933"/>
    <dbReference type="EnsemblBacteria" id="EFI33598">
        <property type="protein sequence ID" value="EFI33598"/>
        <property type="gene ID" value="Dthio_PD0933"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1530385at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088284" description="ATP synthase subunit b" evidence="16">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI33598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="187" mass="21204" checksum="864546548C0921D0" modified="2010-08-10" version="1">MNTKTKLLILGAVLLAAALFNLADPLTLPDDARDQIWRVINFIIFLTIIYYAGGKKLFEFFPSRSNEIETEIKDLETRRQEAEKKLQDVEKSISNLEQERAQILEQAKTQGETLKQQIVAKAESQAEQIKEQAKVSAQQEAKLALQEIRAELAEKVVESTEAMIKKKLKAEDHKALINDSLTRVVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSE2</accession>
    <name>D6SSE2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="4" type="ORF">Dthio_PD0943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870958.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0943"/>
    <dbReference type="EnsemblBacteria" id="EFI33608">
        <property type="protein sequence ID" value="EFI33608"/>
        <property type="gene ID" value="Dthio_PD0943"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1829294at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="3">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="11662" checksum="A785218E670C98E0" modified="2010-08-10" version="1">MSKELTGTLPSPGTVSEEEIKEPQRYKVLLHNDDYTTMEFVVHVLQKVFHKTESEAMHIMLSVHKNGTGVCGIYTGEVAETKVAMVTSMARKKGYPLKCTMEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSG5</accession>
    <name>D6SSG5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0966"/>
    <dbReference type="EnsemblBacteria" id="EFI33631">
        <property type="protein sequence ID" value="EFI33631"/>
        <property type="gene ID" value="Dthio_PD0966"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="214"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="422" mass="47721" checksum="4ACE5A4DAB5C82EF" modified="2010-08-10" version="1">MIQDSRQVNSDEGTGPDNVYVARQPVFDREMNIWGYELLFREGAGSQSAAFQDGDLATSRVIADGFGLATEWLRENQRVLINYPASMLLGGSPRALPPETAVVEILETVRPDREILEICIQLKEEGYSLALDDFVGSPGYEPLLELADLVKVDVLGMHRDELERIVNDLQRHKCLLLAEKVEDLEMFDCCRELGFSYFQGFFFSRPQLVSGKKLSSSRISKVNLLQELGRPDLDFTRISEIIKGDVSLSYRLLRYINSPGMGLAYDVKSISQAVTMLGQRRIAAWLRVLVLADMDPSPRARELLFFCLQRAWFLEAVCDRGEAVCMESDSMFLLGLFSSLDALLAQPMEEIVQKISLDERLRDVLMGRNPEMQAWLDLAMAGERGQWDIVERTLKHLGVSREDAARIQNQATARARQFLDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSP4</accession>
    <name>D6SSP4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1049"/>
    <dbReference type="EnsemblBacteria" id="EFI33710">
        <property type="protein sequence ID" value="EFI33710"/>
        <property type="gene ID" value="Dthio_PD1049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="39" mass="4236" checksum="295E717398D90309" modified="2010-08-10" version="1">MLSQLKEVNLKSCNQKTANNSSKIRALCTAVRSLAMPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSR2</accession>
    <name>D6SSR2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD1067</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871077.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1067"/>
    <dbReference type="EnsemblBacteria" id="EFI33728">
        <property type="protein sequence ID" value="EFI33728"/>
        <property type="gene ID" value="Dthio_PD1067"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="276"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="345"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="416"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="654"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="811"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="14">
        <location>
            <begin position="1057"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="898"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1017"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="925"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1018"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="860"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI33728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1162" mass="130495" checksum="A4C96828D678BBF4" modified="2010-08-10" version="1">MQNEFYKDVLLELALSISGEFDLEKLLKKCMPQFLRKLDCTAAAVVNTADDKGIVLCLPRYMSRNEDFAAMLQQLAREADTDGFQDWLLLQEQDSFHYAFRLQDFGILVLSRSRSFEPFLINELLPLTAMLARACRSCLEVEKRRQAEEELSNSKALLEATLDSIPDIIGIQKPDHTMIRYNQAGYDFLGLTPEEVKGRKCYELIGRSVPCSSCTSARAVRTGRQGFKEKYLPEYDRYLECISQPVFDSQGSVHLVVEQLRDITQRKRSEKKLLTQKAQFESLFTNTSDAMVYFDADLKIFNVNTRFTEMFGHDLEEVRGRNIIDVVDPEGKETHYGAYRILAGEKVEMECTRYSRDGEPREVLLKGGPVLVDGNITGGFAVYSDISQRKNYEKEIIRARDAAEEASRAKSDFLANMSHEIRTPLNGVVSMMSLLEETSLGPEQREYVDMATISSESLLNIINDILDFSRIEAGRLELTRQNFDLEREISRVMLLLTKRARSKEVELLVDYDLQAPRRVRGDNLRLRQILYNLVGNAVKFTEKGYILVQVSLAEAGEEKARLKISVQDTGVGIPVHMQEKIFEHFTQVDYSSTRRHGGTGLGLAISRSLVRLMGGDLQVMSREGEGSTFFFELDIGYADDASEFIEDSELSGMRAMIVDDNAINRKILAGYLEKWGVEHESAADAYQALDILNQNHQQGKSFDFALVDHAMPGMDGIELASRIREQDQEKGMGLIAVSSLWGQVSSGEFFQKGFDSYLPKPVNSEDLLAGIKACLHGRKGDNKRPLQPAAPVRQENAHEVQAGPAAGAGPRILLVDDNHINRRSVQIMLKDTAGGLVSVENGQEALEKMQEDSFDLVLMDVQMPVMDGLEATRRIRSMEQGTEDKDLGVEVAEEILESPNPQIPKSPNPSIPESLNPQIPKSPNPSIPESLNSQIPKSPNPSIPESLNSQIPKSPNPSIPESRNPRIPIIALTANAMPSDREKCLSAGMTDYIAKPVQKIELLAMLKKHLPAGFFDLQDGKGRDERAGAEEDSGQPPGHDEYQVFNTRDFMDRYEQDLEIAAEIMQDFLSDLQVEPEHIQAALARHEAGDADRLAHKLKGSAGYTGAERIRLHCANIMHSSRQENWQEAHKEMQLLQREAQRFEAEARAFFQTQEVELQAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSR5</accession>
    <name>D6SSR5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Dthio_PD1070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871080.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1070"/>
    <dbReference type="EnsemblBacteria" id="EFI33731">
        <property type="protein sequence ID" value="EFI33731"/>
        <property type="gene ID" value="Dthio_PD1070"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088191" description="Histidine kinase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="14">
        <location>
            <begin position="259"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="312"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="14">
        <location>
            <begin position="390"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="14">
        <location>
            <begin position="520"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="588"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="834"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="15">
        <location>
            <begin position="1016"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="883"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI33731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124743" checksum="5ABCD4D9DD95FE0C" modified="2010-08-10" version="1">MLKTCTAITIFFLVLMTCGAGHIYADSHHLPGFEDLFEKHGSVMLVIDSDTGYIKRANQAALDFYGYSAQELGDMKIQDINVLSHREVQEEMRRASLQDRNYFQFTHQLATGEERSVEVYSWPYSTDEGNYLYSIIHDVTPRIEAEKAQQFFLFLGITTVLVVIIALLMKYIYSSRAAASRLQQSEEKLSAIFKAARNVGLVVTDMQSVVQEFSPGAEKIFGYSRDEIMGRYVGVLHLEDESSRFPEYIARLYEQQEGFSVETRLVRKSGEIFPALLNFEPYCDDKGRMVGTLGVTLDITERKKAEEALSKSEEMFRQMADNMGEVFWLRSGDNSRMLYVSPSFEKVFGRSRQDLYHDPNCFVDMVHGDDRSAVLRELDREVSGDEDASFNMEYRIVRPDGEIRWVWARSFPVRDAQGVIIRYTGIAVDITRIKEAENEFKALSREYETVFNGTSDALFLVQVLGEESFRFIRNNLTHEQLTGLTMEVIQGRTPQDVLGRDLGGQVSRNYQRCVQARAPISYEETLDLPGGERVWFTTLTPVFENGDISYIVGSAQDITERKNAEIELYQAKEQAEKASMAKSEFLANMSHEIRTPISGIIGALDMLASESADQSRKDLVDMTLESARSLEQIINDILDLSKVEAGKLDLVHEDFSLRSLVRRVLGLYSIQARNQGIALKVDADSRLPEYVRGDAHRLEQVLRNLVSNAVKFTQAGHVLIRVKAMDIDEHKATVEFQVEDSGEGISGDFLPSLFDSFTQADITYGKKHQGSGLGLAISQRLVQMMGGEIQVQSTPGRGSVFSFALTLGISSVEDKKAKELEDRAADAGISSPLSILVVEDVELNREYMGYLLESRGHRVQFASNGEEAVSAFEPGRFDLILMDIQMPGIDGLEATRRIRSMEGERLGERGMEHGARGGTPDVGSRDSARVPIIALTAYAMPGDREKFLEEGMDGYVSKPVDPSKLLQEISGLAVPGGGGVLQGDQSGTQEPETKKRDMVPDFISREDLDKRYAGHVDFWSGMFQRFLQEELQQYRENLQDAVDRQDMDAVSSLGHKLKGALGTLCVAGAAQKSSELDLAAREKDLEGVSRAWEELLQELHKLLEYRDQGNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSR9</accession>
    <name>D6SSR9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1074"/>
    <dbReference type="EnsemblBacteria" id="EFI33735">
        <property type="protein sequence ID" value="EFI33735"/>
        <property type="gene ID" value="Dthio_PD1074"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026354">
        <property type="entry name" value="4helix_suffix_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04258">
        <property type="entry name" value="4helix_suffix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="292" mass="32295" checksum="A90616EF8473D389" modified="2010-08-10" version="1">MPRKSTVAYPVTLQVKTDLALAAAFLGLISAQKSEYIQGMGKHMVIPAHGGFKKLRSFAVSLTVHDGTVIFCGRFIRKTSRTRDQMEQAARSTVQNIVEGSLASGTSKKSELKLTNVARASLGELIQDYEDYLRQNSLLIWDKDSRIVLAMRRRLAGKLPPPQNAPPPDKDPHQEQQVLDEPLLAALTAMRIKPAETCANIMLCLAHQASFLLGRQLKRLEKDFLEKGGFTERMYQARTRSRQGGVREPAAPWNPEARALGMSDTSDLSDTSDLSDLSDLSDLSDQSDTPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSU4</accession>
    <name>D6SSU4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871109.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1099"/>
    <dbReference type="EnsemblBacteria" id="EFI33760">
        <property type="protein sequence ID" value="EFI33760"/>
        <property type="gene ID" value="Dthio_PD1099"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="PTHR23264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="293" mass="31852" checksum="A6C732CDE4818BBD" modified="2010-08-10" version="1">MKDLKMAPTCPGAQDKQKEKQDKDAKLRSRMDRISKKLVVMSGKGGVGKSTVAANMAVGLSLQGYRVGLLDLDVHGPSIPRLLSLTGEKPHMDKDFMEPVPWSRNLWVMSLGFLLPSNQDAVIWRGPVKMGLIRQFLQDVAWGELDYLVVDCPPGTGDEPMTVLQLLGEGTGAVIVTTPQAVAVDDVRRSVSFCRDMDTPVAGIVENMSGYVCHSCNEHLDIFTSGGGESLAREMNVPFLGRIPIDPEIVRSGDEGYIYVKTHPQSPAALIISSMLESVTADNRKDAEATEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSZ0</accession>
    <name>D6SSZ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thymidylate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871155.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1145"/>
    <dbReference type="EnsemblBacteria" id="EFI33806">
        <property type="protein sequence ID" value="EFI33806"/>
        <property type="gene ID" value="Dthio_PD1145"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1155446at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016741">
        <property type="term" value="F:transferase activity, transferring one-carbon groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="2">
        <location>
            <begin position="102"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="224" mass="25834" checksum="E606A174DFBF2DD9" modified="2010-08-10" version="1">MVQHISITATDIPDAWFQALYAIIDHGCKYTIQHGSMVGEERQEFDYVSVLIENPYMEPWDRMLPQVPPHLGIPNPVENGYVEQYMPYLMSPHKEPGEDYTYGERIYQQVLYWIGKFNQTWATNQAILQVGRPEDHLLNDPPCLRHIDMRIRDGRLIFYPYFRSWDLWGGFPANLAGIAVLQKYMADSIEGVSPGPILASSKGLHIYGYAEELARIRTCRKDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSZ4</accession>
    <name>D6SSZ4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="9" type="ORF">Dthio_PD1149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871159.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1149"/>
    <dbReference type="EnsemblBacteria" id="EFI33810">
        <property type="protein sequence ID" value="EFI33810"/>
        <property type="gene ID" value="Dthio_PD1149"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="295"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="550" mass="60011" checksum="B924B64323390A31" modified="2010-08-10" version="1">MKIGLLQLNPVVCDFEGNARGIVQACMEASGQGADICVTPELAVIGYPARDLLLREDILEKCMQSVRFIARETSGVGPLLLGSPWCFPGRTGEVYNSACLLDKGRVIKVFSKVLLPEYDVFDEKRYFCAAEAPGVFEYKGKVVGVSICEDAWNDEDFWDRPRGGVNPMQELARQGADIIINMSASPFGLGKHGIRQAMMGSLAVKHRVFFIFCNQVGGFDDLVFPGRSMVFGPDGSIMGRGREFERDVFVFDTSNPAKSDSHEHDLDVPAEAWRALVLGTRDYVRKSGFSRVLLGLSGGMDSALTAAVAASALGPENVTGVLMPSPHSSPGSIDDSMKLAESLGIKTVTLPISSLMQGFDQALEDVFSGMHPDVTEENIQSRIRGNLLMAMSNKWGDMLLNTGNKSELAVGYCTIYGDMAGSLAVLADVPKTLVYDIARWLSTKGGPIIPEAIINKPPSAELRPGQKDRDSLPEYDILDEILRLYVEKGASMQEICTRGFEADVVQKVLDMVNRSEFKRYQAPPGIKITDVAFGPGRRMPLASRCLIKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST50</accession>
    <name>D6ST50_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871215.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1205"/>
    <dbReference type="EnsemblBacteria" id="EFI33866">
        <property type="protein sequence ID" value="EFI33866"/>
        <property type="gene ID" value="Dthio_PD1205"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="68"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="387" mass="42808" checksum="06930321169F14BD" modified="2010-08-10" version="1">MKKFVTLAIILSFLGLMGYKVYQDILFPEPASNGPGQRAQAVSVEPVRTETLLHRAEITGTLVAETSFQVAPRVSGRLEKLHVDIGDRVARGDIIAELDSEEFAQEVHMATAELELARAALVESSSELEVARKDLDRSQRLFERGNLSQSELDQAQSVFDVRQSRHDVAQAQVRQRQAALEAARVRLEYTTIRARWSGDDPTRRAARRFVDEGDMLQANEPIVTIICTRNLKAVINVIERDYPFISTGQSAVIKPDAFSDLQLEGTIIRLAPLLEDATRQARAEVLVPNPDGRLAPGMFVRVQIELGQRPQATAVPSAALARRNGSHGVFVAHRDTMQAHFVPVRTGLQDGRLVEIIEPELEGYVVTSGRHLLVDGADIVVPEGFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST62</accession>
    <name>D6ST62_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871227.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1217"/>
    <dbReference type="EnsemblBacteria" id="EFI33878">
        <property type="protein sequence ID" value="EFI33878"/>
        <property type="gene ID" value="Dthio_PD1217"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="260" mass="28823" checksum="AE180775BB5D9EDD" modified="2010-08-10" version="1">MVNSYNVPSPTEHPVCVRNLYMGFPGETLLENVSFDVYTGEIFVILGGSGSGKSTLLKHLIGLYSPLDGEIFVHGRNLTRATPTEKTQIMNSIGISYQSGALFGSMTLLENVRLPLEEFTDMPLEAMNLVCRLKLFQVGLEGYEKHMPSEISGGMQKRAAIARAMALDPSILFLDEPSAGLDPLTSLDLDELILSIARTLKITFVIVTHELDSIFKIADRMIILDKRNKNLAAQGSPLELSRTHTDPWVRSFLKREKIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST89</accession>
    <name>D6ST89_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD1244</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FliM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871254.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1244"/>
    <dbReference type="EnsemblBacteria" id="EFI33905">
        <property type="protein sequence ID" value="EFI33905"/>
        <property type="gene ID" value="Dthio_PD1244"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748746at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17908">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002888">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00955">
        <property type="entry name" value="FLGMOTORFLIM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01397">
        <property type="entry name" value="fliM_switch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="12">
        <location>
            <begin position="251"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="325" mass="36499" checksum="8C53BF33EF174A7A" modified="2010-08-10" version="1">MNKILDQGEVDALLQGLTGGEVETETDVPEEDSGVVTFDLSNQDRIIRGRMPVLEIINDRFARLATNTMANAMRKRVDFNPISIDMSKFGDFMRSLPVPTSINIFKIDPLRGNALMIIDTRLVFALVENFFGGTGSQPKIEGRDFTPIEQSIVVKVSKMLLSNLEDAWRPVHEVNIELTRSEVNPQFATIVPPSDVVVVVTFEVELENAIGSMVVCLPYATIEPIRSKLYASYQSERLEVDHAWLSRFKERLLEIPVDFNVTMGKTQITGRQLLNMEAGDILMLDTDQEDLLKAYVQGVLKFHGVPGFTKGNKAFQVVQEEETNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6STC4</accession>
    <name>D6STC4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871289.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1279"/>
    <dbReference type="EnsemblBacteria" id="EFI33940">
        <property type="protein sequence ID" value="EFI33940"/>
        <property type="gene ID" value="Dthio_PD1279"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12475" checksum="1C9E0B354674B670" modified="2010-08-10" version="1">MRQVEIWEIDLNPTIGSEIKKKRPAVIINNDSIGILPLKVIVPVTEWKDSFEGAIWLVKIVPDSDNNLMKLSAVDTFQIRSVSTKRFLVKTGSVSSRVLEEIKTAVKAVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6STE7</accession>
    <name>D6STE7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871312.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1302"/>
    <dbReference type="EnsemblBacteria" id="EFI33963">
        <property type="protein sequence ID" value="EFI33963"/>
        <property type="gene ID" value="Dthio_PD1302"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1484850at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="437" mass="49186" checksum="C8D430C9FCC311F2" modified="2010-08-10" version="1">MSQDRIDFYEQVLELEPGSKLFYTLARLYCEHDHLEKAQAVLESGLEKHPEHMQARLLLASVMERAGNSSAARGVYREIFDRVLDSPEFWSGLAAAFKEEGRDEPALAAAFLSSWISDHSLTWSRVFQNGLDHLKKSHVPETPPAEPAPAHPHPEPEPDESDPEPDESDPEPDTEPANDASRDFSLEPLDSEDTQIPGEEAAHEAPLESMDAVEEDAQPEASHEDFPELSEPQKAPEEEPDAVEHEMEHATTQAGEDAPLHEEANQHDELQEIEPGSIAGEEEFDDPEEVEDIKFEDDARTRSMADLLAAQEEYQKALDIYRELWVRSLPGPERLELESIISGLQQTLGLDHDSRDQSPVTAEMEEPSALNTDPAARQPDNTDEKEPQQFLEDREKNFLETDPEDAGEKEKSTDREASDKKEVMSFLSRLADRLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6STQ2</accession>
    <name>D6STQ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871417.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1407"/>
    <dbReference type="EnsemblBacteria" id="EFI34068">
        <property type="protein sequence ID" value="EFI34068"/>
        <property type="gene ID" value="Dthio_PD1407"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1936285at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40047">
        <property type="entry name" value="PTHR40047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09323">
        <property type="entry name" value="DUF1980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="36742" checksum="C4D7758274BFC1DA" modified="2010-08-10" version="1">MLKTIILFALAILQVKLIYTGDILYYLSPKMLPFFYFSTTVFLLLAAYRAMLILAESSGLETTSQACDCCAHDEDASKFSRTAMYILFCLPLLTGFLVPPKLLDSSLVDKKGIIYREVASTPSDQLPSETRQQYTDQPGEIDHEWWEEYEFETQEQNVQEEEQQALRDELGIWYDEDYYRDLADRLIDGDKIVVSDSGHLDVMLVIAAYQEEFQGREIELTGFVYRDDHMSRDEVALTRTAITCCLADATFYGTLIRGEDLHRLERDQWITVKGEIDLARVQGQNMIMINARQVQEIDPPDSPYVYPYLYQQYNPEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6STR2</accession>
    <name>D6STR2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871427.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1418"/>
    <dbReference type="EnsemblBacteria" id="EFI34078">
        <property type="protein sequence ID" value="EFI34078"/>
        <property type="gene ID" value="Dthio_PD1418"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="94"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="199"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="401" mass="45652" checksum="EEBBF1F14E8D882E" modified="2010-08-10" version="1">MSLTDVQVKGLKPGSTKYRVKDKDGMYLEVTPAGGKLWRFKYRFNGKNKLLALGKYPDVSLAKAREKLSIARQQIAEGKDPAYIKKIEKAEKENTFKAITDEWWRAKKSTWTPGHAEKVYRRLEIDVLPYLKDRPIKEITAREILEVLKKAEARGVTDTAYRLAQMCSNIFIFALASGRAEHNPAADISKALTAHPKTNRPAITEPDEIKELLLAIDGFTGSYTVLCALKIAILVFVRPGELRQASWAEINFDEALWYVPSQRMKMKREHLVPLSGQAVKILKDIHPLTGAGHYVFPSIRTNSRPMSENTLNAALRRLGYPQEKLCAHGFRTMASTRLHEMGWPSDIIEFQLAHVDQNKIRGIYNRAEYLDQRTKMMQAWADYLDDLKTGKTAKKFNNTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STT6</accession>
    <name>D6STT6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871451.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1442"/>
    <dbReference type="EnsemblBacteria" id="EFI34102">
        <property type="protein sequence ID" value="EFI34102"/>
        <property type="gene ID" value="Dthio_PD1442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="67" mass="7701" checksum="1CC0EA9013E5EB93" modified="2010-08-10" version="1">MSKTCRNCLNNQEFSDVMVNGVLLRDPQYCQRADEMLPRFGNAVVPVLDDRDVDVSTDCPYWEDADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STU8</accession>
    <name>D6STU8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871463.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1455"/>
    <dbReference type="EnsemblBacteria" id="EFI34114">
        <property type="protein sequence ID" value="EFI34114"/>
        <property type="gene ID" value="Dthio_PD1455"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031UCY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1584882at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="222" mass="24413" checksum="34B3E2C67482AA9D" modified="2010-08-10" version="1">MTRIYIPATSAEQWAQFLAEPARQWRKGYSARTLAYSWQDADGFPDEVGAVLGLKFPAAEILLAFPEHQVPLPGGSRPSQNDIWVLARSQGKLISIAVEGKVSESFGPTIQEWQAQSNPGKTARLEFLQRLLELDAVPLSIRYQLLHRTASALIEAQRFNAQHALMLVHSFSQSHEGFQDYAAFAELMGGRASKEILNSAGSLSGTLLHIAWVQGNPASLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6STV6</accession>
    <name>D6STV6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871471.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1463"/>
    <dbReference type="EnsemblBacteria" id="EFI34122">
        <property type="protein sequence ID" value="EFI34122"/>
        <property type="gene ID" value="Dthio_PD1463"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445933at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="736"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="901" mass="98720" checksum="D80902F867D33E84" modified="2010-08-10" version="1">MSLKQLDSLFRPKSVAVIGASNRPGSIGSVVMHNMLRGGLPGPILPVNPRYDAVAGILAYPGVRELPLVPDLALVCTPPDTVPGLMQELGIKGTRTVLIMSRDLNKQLDESGQTLQQRVLKTAKEHSMRILGPDCLGIIVPRSGLNASFGHTDIAQGKIAFVSQSDALGIAVLDWAGSKGIGFSHFISLGDCLDIDFGDIIDYLKGDPHSTSILLYMESVSNARKFISAARSASRNKPLVVIKGDKFNISAVRDASYIDSPVSTDDIYDGVFRRAGMLRVFDLAELFDAVEAMARYKPLRGDRLAILSNGGGPAMMARDVLKTRGGSLAELSEQTRQQLQHGLQAELSHQEPVRIIDHASSETYSRALEILIQDQNVDAIMVIHVPTAFASSQDIAGAVINSLGRTRKNVITVWLGEKDAAQARRMFALAGIPTYETPDQAARLFMDMVRYRRNQELLMETPDSVPSDFSPDPMAARAIIKNALDENRSFLSAPETNEVLSIYTIPVVPTRQAADAQEASLISRELGFPLALKISSPDIQDKKHSGALALDLESSGDVLKAAAAMQARLAAGYPQASLEGFIVQKMVHRPTAHELTAGVTQDPDFGPVLYFGQGDTAGRIYKDLAAGLPPLNMTLAREIIQNTRISSLLEDSKNRPAIDMQALRLILVQLSQLVIDLPEIQEVNLKTILADAGGAVVLDARISIASTASAGEERLSIRPYPKYLEEHAELPSGLRLLLRPIRPEDERSHQDFVEKLSAEDLRMRFMGFVHEFSHSQLAQLTQIDYDREMAFIAGAIEDGAWKETLGVVRCFFDPDNTNAEFAIVVRSDLKSRGLGTLLMDKMIRYCRQRGLKELTAFALRENTGMHALAKKFGFRMESDPEDPEITILKLEMTPRIIHPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STV8</accession>
    <name>D6STV8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871473.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1466"/>
    <dbReference type="EnsemblBacteria" id="EFI34124">
        <property type="protein sequence ID" value="EFI34124"/>
        <property type="gene ID" value="Dthio_PD1466"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="entry name" value="PTHR28630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="129" mass="14272" checksum="44A0675CD7947860" modified="2010-08-10" version="1">MQEKEQFLDDLGVKTAVVTFEAGFMARAYVEDTGLKWPLLVDEDRALYHGYGMLSAGIRELIGPATLWLYLKEALRGRLPRKSTGDVSQRGGDVLIDPGGTVRLHYIGKTPADRPGVESILKIVQESQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU33</accession>
    <name>D6SU33_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871815.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33124">
        <property type="protein sequence ID" value="EFI33124"/>
        <property type="gene ID" value="Dthio_PD0439"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033Z70">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879053at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17472" checksum="93E5851503E4CE42" modified="2010-08-10" version="1">MGQETIPHQSRMDAARKLVVDSAFVPCPAEDGDEIYPNGIFHFNITKMLEHINQNPGQYLLEEIPLENLSLFSSSLNEDYVSIADITQPLILAEISPGRYVVIDGHHRLERASRMRVKAVPAYRLHVHQHIPFLTEKRAYLAYVEYWNSKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUE4</accession>
    <name>D6SUE4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871617.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0238"/>
    <dbReference type="EnsemblBacteria" id="EFI32924">
        <property type="protein sequence ID" value="EFI32924"/>
        <property type="gene ID" value="Dthio_PD0238"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="301"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="460"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="575" mass="62762" checksum="2483D58EF6A9A928" modified="2010-08-10" version="1">MSWKNLSIKWKILAISLSAPIVVALIFAYMQISQVRQNAHESIVDTSRAITVMAEATRQDMANKLTMGIIRPFDELETREEILEAVPIVTAMNVARENADEAGYNFRVPKINPRNPDNEPNEIEREVLEGFQEEYQEEKVLITRDEIRYFRAIQLTQDCMACHGDPAGEEDPVGGTKEGWQVGEVHGAFVITTSLDETNQAIQRAQMNMALWTAAILAVLGTIIYIMIKFSIVRPLSMAGDFLRKISSGDLSRDIDSSKRDEFGNMINDLGQMSANLRQMLMGIAQKAQSLLESARSLDQVSGKLSDESGEMSARSNTVASASEETSTNMNSVAAAMEQASTNVSTVATAAEEMSSTLSEISGNADQARNITGKAVDQAQSASDRVKLLKDAAQEIGKVSETITQISSQTNLLALNATIEAARAGEAGKGFAVVANEIKELADQTGKATEEIKQKVEHIQASTSDTTQEIDMVMQVIREVNEFVDSVAAAVQEQTQTTRDIAENVGQASSGIQEVNENVAQASSVSQDMTRDISRLSESSNSISQSSSTLKQSSQSLSEMAEELQNMVEKFKFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUF9</accession>
    <name>D6SUF9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin reductase</fullName>
            <ecNumber evidence="1">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871632.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0253"/>
    <dbReference type="EnsemblBacteria" id="EFI32939">
        <property type="protein sequence ID" value="EFI32939"/>
        <property type="gene ID" value="Dthio_PD0253"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="33174" checksum="00B4F76D8BBD6C3C" modified="2010-08-10" version="1">MKEYESVVIGGGPAGVTAALYLLRAGIQVAWVEKLSPGGQVLLTETIENYPGFPQGIKGFELVDLFTAHLEGFEYDKIGDEATEIKASDGKFETVLSQESIISRSVIISTGANWKKLGVPGEGKFNGRGISYCALCDGNFFKDQEVACIGGGDTALEESLYLTKLVKKVYLIHRRDAFRGSRIYQDKVVNNPKIDILYNTVVREFAGDKELESVKLENVQTGEESDLEVQGAFVFIGLIPAAPSLPQEVETDELGFIKTDTEMSTSIPGLYAAGDIRSKLCRQITTAVGEGASAAHNVQVYLEKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUH8</accession>
    <name>D6SUH8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="9">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mraY</name>
        <name evidence="10" type="ORF">Dthio_PD0272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871651.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0272"/>
    <dbReference type="EnsemblBacteria" id="EFI32958">
        <property type="protein sequence ID" value="EFI32958"/>
        <property type="gene ID" value="Dthio_PD0272"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI32958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="358" mass="39566" checksum="12C8A0A776F96333" modified="2010-08-10" version="1">MLYHLLYPLSEDISFFNVFRYITFRSIYALLTALLLSLWLGPKFIKWLQRIKCGQYVQEDGPDHQVKQGTPTMGGVLVAFSLAVSVLLWGDLTNKLVWMCLFVFGGFFLVGFFDDYLKVIKKHNQGLSVKSKLLGQGIIALGAVSMLLTMPGYNTELLIPFFKDLRPDLFLFYVPFAAVVMIGASNGVNLTDGLDGLAIGPYIVSAGCLSIFVYVSGHYHLADYLQVPYIPGLGEVTVFCGALVGAGLGFLWYNAYPAQIFMGDTGSISLGGTLGFIAVLCKQELLLIIVGGLFVIETLSVILQVGYYKMSGGKRIFRMAPLHHHFELKGVPESKIIIRFWILSILFALAALSTLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUL7</accession>
    <name>D6SUL7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ORF">Dthio_PD0311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871690.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0311"/>
    <dbReference type="EnsemblBacteria" id="EFI32997">
        <property type="protein sequence ID" value="EFI32997"/>
        <property type="gene ID" value="Dthio_PD0311"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="12975" checksum="D05803D74586F6D7" modified="2010-08-10" version="1">MKLSKNQRRIKRKYRIRKKIRGTAEKPRLVVFRSNKHIYAQIVDDADARTLAACSTHNLDEHSGLNATAAQSVGSKLAEQATSKNISTVVFDRNGYYYHGRIKALADAARAGGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUN7</accession>
    <name>D6SUN7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ORF">Dthio_PD0331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871710.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0331"/>
    <dbReference type="EnsemblBacteria" id="EFI33017">
        <property type="protein sequence ID" value="EFI33017"/>
        <property type="gene ID" value="Dthio_PD0331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="156" mass="17947" checksum="35504382927C5270" modified="2010-08-10" version="1">MPRKGPIPKRAVLPDPVYHSRMVSKFVNRLMVDGKKSIAENLLYKAIEELGEKTSEEPLKAFNQVVENVKPHMEVKSRRVGGATYQVPMEVRPSRQEALAIRWLVLYARNRGEKGMDRKLSSELLDAYNNRGGAIKKKEDTHRMAEANKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUW3</accession>
    <name>D6SUW3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0001"/>
    <dbReference type="EnsemblBacteria" id="EFI32719">
        <property type="protein sequence ID" value="EFI32719"/>
        <property type="gene ID" value="Dthio_PD0001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="3">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="191" mass="22693" checksum="44802B50C36AC113" modified="2010-08-10" version="1" fragment="single">MLDRQIQDYLEWMNNAGYAPWTMAQHSQILNRLLDFVVLNSIPWERTFARDTLQAFKDHVQVKYAGFVLRGFMRYLHQNGIICLPPGALPEGRGRSKLQRAQLPRLYEEYLQFYTQTRQVGHVQIYRVRGTLSALNDYLQNQGMELKDLDVLHMDAFLAERNRKYAPETRIHERSGLRGFLRYLYLERQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUX2</accession>
    <name>D6SUX2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871827.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0011"/>
    <dbReference type="EnsemblBacteria" id="EFI32728">
        <property type="protein sequence ID" value="EFI32728"/>
        <property type="gene ID" value="Dthio_PD0011"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8908" checksum="D450C2310514C657" modified="2010-08-10" version="1">MITPAQIRAARGLLRWSQKDLSKKSGVSLRAVNRVESEECDPRMSTLKALEYTLEQAGVVFINEEHKVGVYLRSTGQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV11</accession>
    <name>D6SV11_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871859.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0059"/>
    <dbReference type="EnsemblBacteria" id="EFI32767">
        <property type="protein sequence ID" value="EFI32767"/>
        <property type="gene ID" value="Dthio_PD0059"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="7"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="341" mass="40021" checksum="EA48EC73B033A95F" modified="2010-08-10" version="1">MSFEIPNPHNACFKDFFKDPEFVKSFIKYHIPEEITSLLDLDTLQVDLSGFVSEEHREYYADVMVTVQLKGHTENVNIYILLEHKSAPEFLTRLQILNYEVQKWMDLKRKGQLQGYLPVIIPVVIYHGKGRWNYSRKFSDLFDLPSEVLRPFVPEFKHMIHDISSMEDDEFKTTAILEIFHLLFKYIHYPELETKLQEIYDLLETIPDQDKVKQYLQAIVQYVAVQGPVSLERLGEYTRRLPGGDEAMQTAAQQIRQEMYNEFKQEKEKVRLESEKRGELKATQETLIDVAGDCHGPLPKSLQDKIKSIDSIDNLRTLTRKVYKTQSLEEFTELVNRATQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV26</accession>
    <name>D6SV26_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871872.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32782">
        <property type="protein sequence ID" value="EFI32782"/>
        <property type="gene ID" value="Dthio_PD0077"/>
    </dbReference>
    <dbReference type="OrthoDB" id="973373at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="8089" checksum="3383726D5850CC00" modified="2010-08-10" version="1">MTLEEGDQWAKVWVQTLANSNQGERDFFLVLENPEGAKFPEGKEELTAQRVVHDDEVGLAGVTDLEPELFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV42</accession>
    <name>D6SV42_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SapC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0096"/>
    <dbReference type="EnsemblBacteria" id="EFI32798">
        <property type="protein sequence ID" value="EFI32798"/>
        <property type="gene ID" value="Dthio_PD0096"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010836">
        <property type="entry name" value="SapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07277">
        <property type="entry name" value="SapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="234" mass="26723" checksum="8C4619CC38329217" modified="2010-08-10" version="1">MQPLSTTRHAGKYFTQAKDYIFTRSRTTVPLVISELPRAVPAFPIAFTYSRNKYILSAVMGLKLEQNLFVTQEGKWRTSYIPSYFRAHPFYLAESQNGKQVVCVDENSGLIGDSGEPIFGEDSKPTQKTQQIIDFLEKIAKERAITDKACLVLNEHGLIEPWEGYGGLYRISEGKLKDLTGESFIQLRDTGGLKVMYGQLYSLTQMSRLRKLAEQETEPDWESMEELDFEKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJQ9</accession>
    <name>D6SJQ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3564"/>
    <dbReference type="EnsemblBacteria" id="EFI36112">
        <property type="protein sequence ID" value="EFI36112"/>
        <property type="gene ID" value="Dthio_PD3564"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="278" mass="31145" checksum="67249152EE1AD1E3" modified="2010-08-10" version="1">MLNKQVMPGTITDPHKTVLARMGFRLHGGGVHTARTIMLQDLKALLSYIDNPEAGKPDYRQAVVNDNCLGKRSGKTRTITFNHLSSLYGLDPGIFIFRNMLHFWKRDNEGRALLAILCACCRDPLLRLSSTFILKTPPGNTLKREDLEEFIDSHRQDCFSRATLKSAAQNLASSWTKSGHLRGKYNKVRTSVQATPGSIAYALLLGHISGLRGQSLFACDFFNILDCSVEQGLELARESSRRGWMVFKNIGEVIEVQFPGLITPTETERLNEQNQTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJT4</accession>
    <name>D6SJT4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869262.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3591"/>
    <dbReference type="EnsemblBacteria" id="EFI36137">
        <property type="protein sequence ID" value="EFI36137"/>
        <property type="gene ID" value="Dthio_PD3591"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2081614at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021377">
        <property type="entry name" value="DUF3006"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11213">
        <property type="entry name" value="DUF3006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="9185" checksum="C79DF5D76A881567" modified="2010-08-10" version="1">MSKQYVVIDVISTDMATLLIGEEEKEWVVRVDELPEGSKEGDWLILDDTGNLLPAPEKTTERRHKIRSKLERLRTSYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJT6</accession>
    <name>D6SJT6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869264.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3593"/>
    <dbReference type="EnsemblBacteria" id="EFI36139">
        <property type="protein sequence ID" value="EFI36139"/>
        <property type="gene ID" value="Dthio_PD3593"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="791672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="6">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="5">
        <location>
            <begin position="145"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="516" mass="58359" checksum="73D4EB1B214D43B3" modified="2010-08-10" version="1">MNRNGNQVEARLWAAADELRANSKLKPSEYSVPVLGLVFLRYADHKFKAAAKELECSGGGRRKIGPADYHARGVVYLPEKARFSYLIQLPEGSNLGAAINDAMRAIEAENTDLREVLPKTYNRFENYLLKELLKTMNSVPMDIEGDAFGKIYEYFLGNFARAEGQKGGEFFTPTAIVKLIVGIIEPYHGRIYDPACGSGGMFVQSAHFVEEHRKNPGSELSIYGQEKVAETVRLGKMNLAVHGLGGDIRQGNAYYEDLHNSKAKFEYVMANPPFNVDRVDKDRLKDDPRFPFGLPKPDNANFLWIQMFYSALNDKGRAGFVMANSASDARGSELDIRKQLIESNSVDVMVAVGSNFFYTVTLPCTLWFLDRGKKNTDRADKVLFIDARHIYRQIDRAHRDWTPAQIEFLANIARLYRNEEPENLHDSQGLMDENFPDGKYVDVPGLCKGATLEDIEAQGWSLNPGRYVGVAAREEEDFDFKERLEELNEELEGLNVEARELEERIAENVVRLLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJU8</accession>
    <name>D6SJU8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869276.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3605"/>
    <dbReference type="EnsemblBacteria" id="EFI36151">
        <property type="protein sequence ID" value="EFI36151"/>
        <property type="gene ID" value="Dthio_PD3605"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1697991at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="198" mass="22608" checksum="067BE9A2915464EA" modified="2010-08-10" version="1">MYIQNKQTGLTLVELLIALAILGVVMTAVVSLFISTIKVYHTNKAILEVQQNVRHVRTVLNNDLKMVGFELDESEIQADNHEFKIGDITYTTQEHTNGDGSQEYDFVRKRNEASNGVTSILMPNLSSKLNFTYYDKDRNEIEPNSNENGDSGNIDNPSEIRKVQFTLCGKAWGRTPFISDQFEHCAEDTIIFRNMYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJV9</accession>
    <name>D6SJV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3618"/>
    <dbReference type="EnsemblBacteria" id="EFI36162">
        <property type="protein sequence ID" value="EFI36162"/>
        <property type="gene ID" value="Dthio_PD3618"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1833204at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="143" mass="16267" checksum="90F1096ADCADB302" modified="2010-08-10" version="1">MEPRVRELLSELYAIESKHTDMLNSPEAVALKMLSYRDRKTEHFVTFLVDNKNHFLSKKLISKGTVDQAPVFPREILRYALLKQASGLILSHNHPGGDPNPSVQDREMTARIKKAAILLGIRLLDHVIVSRTGHYSFQEHGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJW9</accession>
    <name>D6SJW9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869294.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3628"/>
    <dbReference type="EnsemblBacteria" id="EFI36172">
        <property type="protein sequence ID" value="EFI36172"/>
        <property type="gene ID" value="Dthio_PD3628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="12059" checksum="E72B17719218ECE5" modified="2010-08-10" version="1">MALLITTQPYAQQEIIKGITRVICEHSPNSRRRFQEKLHNLAALPSTDVVVTGYNESFSHPEFTLAWYRQNGNPDLHPLERQEGPFMIGVMVFHDFEDCWCTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK11</accession>
    <name>D6SK11_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine synthetase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869336.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3671"/>
    <dbReference type="EnsemblBacteria" id="EFI36214">
        <property type="protein sequence ID" value="EFI36214"/>
        <property type="gene ID" value="Dthio_PD3671"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="98"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="434" mass="49721" checksum="EF42CFCCB9ACC061" modified="2010-08-10" version="1">MSNTDIEDMMEPTDSTEIIFTDLNGRIRRLPVNPRNIRQISVEGIGFDGSSVAGIATVEHSDRLLMPVLDSLKVLPFKEKKTSLFVGTIHNEHGERASTDPRYVLEKVVEEAEEMGFRFQASPEYEFFLFHQDQYSRDLNTDNAGYCEADPRDQGERVRNRIIDVLTSCGVPFEKAHHEVSPSQHEINFECADPLNAADRTLVFNYVAHMIASEHDLHASFMPKPFNNKNRNALHIHLSMQDLDGQNIFYQQGDEHNLSHVARQFIAGILKYARQTSILMASTFNSYKAYVIEREAPVVVGWGPRNRTSMVRIPYATNAQATRLELRSPDPAGNIYLQMAAFIKMGLQGIREELDCNSPDRGKAYFQSMKKKLWDTRLLPKTMFEALVEAEDSPFLKDLLGEQQYQNLMNIKTAEWEDHRTSVTAMEFDRYLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK16</accession>
    <name>D6SK16_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869341.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3676"/>
    <dbReference type="EnsemblBacteria" id="EFI36219">
        <property type="protein sequence ID" value="EFI36219"/>
        <property type="gene ID" value="Dthio_PD3676"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="127" mass="14034" checksum="11381CBB84CED784" modified="2010-08-10" version="1">MSKFSFMVVDDSLITQRKLSQLLEELGHSVAGTCVNGQQACEKYIQLKPDLVTMDITMPVMDGIEATKKIIESDPEAVVVMVTSHGQKQTVIDAIGAGAKGYILKPFYRDNVAQTLNKVINKYLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKC0</accession>
    <name>D6SKC0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid maintenance system antidote protein, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869442.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3789"/>
    <dbReference type="EnsemblBacteria" id="EFI36323">
        <property type="protein sequence ID" value="EFI36323"/>
        <property type="gene ID" value="Dthio_PD3789"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="13801" checksum="61142CB2DD8A8D7A" modified="2010-08-10" version="1">MPMKSKSQIATDAERRLPRNRPPTHPGEMLFEEFVKPLGLTQVELARCLGVSYPRLNEIIKGKRSVTPDTALRLSRVLGMSPDFWLGLQQDWDLWHVMNSPEAENINRLKPIPRNQHSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKC7</accession>
    <name>D6SKC7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869449.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3796"/>
    <dbReference type="EnsemblBacteria" id="EFI36330">
        <property type="protein sequence ID" value="EFI36330"/>
        <property type="gene ID" value="Dthio_PD3796"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAUV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1834457at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="25205" checksum="73724576993E9F3D" modified="2010-08-10" version="1">MYIFKPDLNILPPAQRNVWNRLGVIPKNFVLYGGTAIALHLGHRSSVDFDFFSHDSFESDRLCHMVSSLGTYEVLQAQEDTLTIVLTDNDPVKISFFGGIKTGRVKSPLETDDKVVLVASLLDLMGHKLKTVLQRVEAKDYIDIACMLKKGFQLEQGLSCVLSLWPFAPVQEIVRTLTYFQEGDFSELSNQDRQILIRACSDVSFESITKYPLNSERISDYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKD1</accession>
    <name>D6SKD1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869453.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36334">
        <property type="protein sequence ID" value="EFI36334"/>
        <property type="gene ID" value="Dthio_PD3800"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="83" mass="9418" checksum="C161475E0BB0747E" modified="2010-08-10" version="1">MRMKVFNKGQVVIPVEIRKALDIKPGDSIEVNFDHERRLIQLRKPDKNESRVLAGSLAAYAKGKQFPSRSGMHEALKQGMINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKD7</accession>
    <name>D6SKD7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cell inner membrane</location>
            <topology evidence="2 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869459.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3808"/>
    <dbReference type="EnsemblBacteria" id="EFI36340">
        <property type="protein sequence ID" value="EFI36340"/>
        <property type="gene ID" value="Dthio_PD3808"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="894"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="922"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="5">
        <location>
            <begin position="341"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1043" mass="113333" checksum="F37D3633A1E23DCE" modified="2010-08-10" version="1">MLRFFINRPIFASVISIIIVLAGTTALRVLPVEQYPEVVPPEVVVNASYPGASAEVVAEAVAAPLEQEINGVDDMLYMESTTTDDGTLQIVVTFEMGTDPDMASVNVNNRVEAALPRLPQAVRDQGVRAEDRSTNILMVPVLYSPDESRDSLFIANYAIMNVLEELNRLPGVGEASVFAPEDYSMRIWQDPDKLARHDLTPSDLADAIREQSAHYAAGRIGADPAPAGVDFTYSVSTDEMLAEPEEYEDIILRSGKNVSTLRLGDVARAELGPQRYGFSAEYNGQQAVGMGVFLAPGANAMETAEVVNEALEEMSVHFPEGLDYTMGYDVTEFIEASIQEVLITLLIAMALVVLVTFIFLQRLRATLIPVTAIPVSIIGTFAGMLAMGFSVNLLTLFGLVLSIGIVVDNAIIVMENVERLMRERSLKAREASIETMKQVAGAVLASTLVLVAVFAPSAFLGGMTGELYRQFAVTIAVSVVVSGVVALTLTPAMCALLLDRQRGRLPRPFVWFNRAFEMQTSAYVWVVSKMVRHAAVGVLLFAVFTGATVYAVTRMAPGLIPQEDQGGFIMAMELPAASSLSRTEQARDKVMDGLMEMEEVESFTGIAGVDIFDMALRSHMGMGFVNLTHWDERQEPGQDAQSMTEKVMGMGQEIQEANILAFVPPPIVGLSLAGGVEGYLEVRGDMDVEELEAMAWELMAAANERPELVNARTTLETDIPNYRADLDREKSRDMGVPVNQVYETMQSTFGTLYVGDFTMQDRNWQVNLQSEKDFRSRPEDLSKVFVRSEHGQMLPLTSLVSLERDVGPDVINRYNVNSAARLMADAAPGYTTGEAKEAVEEVAEKIIGNGETSLGWIGEAFQLDVAAGAGGTAFGLGLVMVVLILAAQYERWTLPLAVASAVPFGVLGASLAAMLRGFPNDIYFQVGLLVLIGLAAKNAILIVAFAAQNRENEGMNSTEAALSAARQRFRPIVMTAMTFIIGVLPLVFATGAGAASRQVIGTVVVGGMLLASTVAILFVPLFYKLMDDVSFYFHNRKMFRDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKF8</accession>
    <name>D6SKF8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-viologen-reducing hydrogenase delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869480.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3829"/>
    <dbReference type="EnsemblBacteria" id="EFI36361">
        <property type="protein sequence ID" value="EFI36361"/>
        <property type="gene ID" value="Dthio_PD3829"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="140968at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003813">
        <property type="entry name" value="MvhD/FlpD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02662">
        <property type="entry name" value="FlpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="940"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="978"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1168" mass="127372" checksum="96C3762730351625" modified="2010-08-10" version="1">MQQKTGAVAVIGGGIAGIQAALDLADSGFYTYLVEKSPGLGGIMAQLDSIAPTSDCSPCLLTTRLIACSRHANIEIHTRSRVLCVEGQEGNMQVHIRKSPAFIDPAKCIACNWCTEACLKAVPDEFNLELKTRKCAYIYYRQSIPSTYVIDQKHCLRLTRGICGICEKICPAGAIDFNEPEKTLVLQAGSVIMATGMNMQKSQDLHDLYSYKSCPDVITSLEYERLTSITGPGHGILKRPSDNTRPAKTAWIQCVLSRSLKHPAHRTCSSICCMHAVKQASSMGRHIGEKIPDTTVFYNEIRFCGKGQEKLLDRGRAMGVRFICSQPHSILPGKDGKGVRITYVHDDSKLITKFFDLAVLSVGMHAGRDSLQQVLAPGITISGNDSIGPISSTTPFESSRKGVYLAGSLASPGDIRHSITHGSGAAVAATERLTRSRFTLTCKKEWPPEKDVSMQQPRIGVFICACGGNISDIIDINALKEFASGLPGVVLAETNKFTCPQFIQDIISSRIIQENLNRVVVAACTPVTHQSLYQDTLKKAGLNPNLLEMANIRNQNSWMHQYNPALATAKARLQVSSAVAKAVIKKILKVRFRKIIPRALVVGGGLTGMTTALSLADQGTQCFLVERSAGLGGHARDTSSVCAAESSRNLVEETVARVQQHPLIITFFNSRVVSCKGSTGNFISNIQSMRNNGIRSTETIRYGAAVLCTGAMEAKPLEYLYAKAEGVFTQDEFCSLMQTGENTFKKAASVVFIQCVGSRETNRTYCSRTCCTRTLKTALKLKEINPGIQVYVINRQMNTCGDKELLYEQARQEGVIFIKYTRDNSPLVQQTPQGLNIKILDHVLKKPVGINTRHLVLATGIVPDPETTRLAAIFNCSLDSDLFLQDRHYFLHPCSLDREGIFAAGLCLQPGPMEESLVQARAAVSGVRNILFKKQLPLESSSAYLTAGCDGCGICIDRCPYAAIKYSACSGEKPGPDPGIWIDEELCEGCGACVSACPGNGVAIDESKMDRIRSQVLSMLHICKNEPSSKIPLVIAFCCSRGPYMAADTAGALKQQSSPCVIIIKVNCIGDLSREIILESLQQGIDGIMILGCPPGECRYRHGEMHIVNQTGNIRAYLKHNRINPDRLMLGWLSSVEGTRIAGIMNTFARRIRRMKVSAGKKARTSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKK9</accession>
    <name>D6SKK9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868354.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2629"/>
    <dbReference type="EnsemblBacteria" id="EFI35220">
        <property type="protein sequence ID" value="EFI35220"/>
        <property type="gene ID" value="Dthio_PD2629"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="146"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="470" mass="53280" checksum="96AE86EA43CB4EE0" modified="2010-08-10" version="1">MSKQRLMIIDDEKDMLQGLSRILPQELENIQVETFSSALSGLESIKRQPVDVLLLDIRMPEMDGMEVLTAVKEIDPWITVVMITAYGSIETAVEAIKKGAYDFITKPFEIPDLVRVLNKALERSLLIRENMNLRKKVSEKEPFADFVGQSPPMRRLYDGIQALAGTDYTVLIRGESGTGKELVARALHELSPRSSRRMVTVNCPAIPEHLLESELFGHKKGAFTGAEQNHTGMFLEADKSTLLLDEIGDLPVSIQTKLLRVLQEREVRPLGSDKSRKVDVRILSCTNQDLEARIQDRSFREDLYYRLNVVTLRTPSLSEITEDIPLLADHFLRSVCNELGLPLKRFSVAAIQSMMHKSWPGNVRELQNFVRRVALFSPEEEIGAADIRVAQDSLYGSAESRQDQDSNGKAVKPYQQAKEELLENFTREYITRLLGQTEGNVTRASDIAGISRTALQKIMRRYEIRSEDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKL5</accession>
    <name>D6SKL5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein family UPF0324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868360.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2635"/>
    <dbReference type="EnsemblBacteria" id="EFI35226">
        <property type="protein sequence ID" value="EFI35226"/>
        <property type="gene ID" value="Dthio_PD2635"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856009at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="600" mass="64856" checksum="A2C8E2675FD85090" modified="2010-08-10" version="1">MAEHDKKEAQEAIKEEMAAASSTGKGRDWSQLWKKEDWWANWLGLALLLFALVVFWGATPSDAPEQLAEHEAVVEYEEERAPFATIEQIKAQDELDSIRARDHGLGPAMGWLIQRPRGWDDNPVEAFYMSESRAAEMREEAKPAYEEAQQATEEALAEAEEAQAAAAEADFEDEALNEEAVNAIDAWLDARDAESSARSDANVSGYNLIPSMILLMIFTGLMFAIGISFMGGNVGTFLVGYPIVFIISIIGFFIGNHAIASEYGLSYVLWCIIIGLLISNTMSTPGWVKPAVQTEYYIKTGLVLLGGSILFGLILMIGAPGIVVAWGVTPTVLIIGYWVGNKYIKLPSKPLNICVAAAASVCGVSAAIAAAAASKAKGEELTIAVGLSLVFTALGMFLMPALVMAVGMNPILGGAWVGGTVDSTGAVVAAGELLGPGAMYTAATLKMIQNVMIGILAFGIAAYWATKVEREGSNVELTVGAALREIWVRFPKFVIGFVAASIFFTIVYEAMGHQMGETIVSDGVLGGWANPLRAWFFAMAFTSIGLATNFRELAKYFAGGKILYHYVFTQGFNVILTLFLAWLMFMVFFPGVTEHLMEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKM8</accession>
    <name>D6SKM8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Porphobilinogen deaminase</fullName>
            <shortName evidence="8">PBG</shortName>
            <ecNumber evidence="8">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="8">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemC</name>
        <name evidence="11" type="ORF">Dthio_PD2650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="8">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868373.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2650"/>
    <dbReference type="EnsemblBacteria" id="EFI35239">
        <property type="protein sequence ID" value="EFI35239"/>
        <property type="gene ID" value="Dthio_PD2650"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1450400at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="9">
        <location>
            <begin position="5"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="10">
        <location>
            <begin position="224"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="8">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="313" mass="34668" checksum="4921E25184DFB470" modified="2010-08-10" version="1">MKKVVIATRGSKLALWQAEHISSRLRERYSGLEVELLKVKTTGDKILDVPLAKVGGKGLFVKEIEEALMDGRADIAVHSMKDMPAELPRGLKLGIIPERESRFDVLLSTSYPDISSLPTGATVGTSSLRRQAQILHMRPDLEIQMLRGNLDTRLRKLKEGIYDAIIVAAAGMSRLNMHADYVTELSPPYFLPAVGQGALGIEYLQDRQELDELLGFMDDFSTRYCIECERAFLAELEGGCQVPIACYCRHEGNNIQATGLVCDLKGERMIRKSVSGKPKDARSLGVDMARQVLEAGGREILAELYACQDDNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKP5</accession>
    <name>D6SKP5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2667"/>
    <dbReference type="EnsemblBacteria" id="EFI35256">
        <property type="protein sequence ID" value="EFI35256"/>
        <property type="gene ID" value="Dthio_PD2667"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="24917" checksum="58F6931809EFB55A" modified="2010-08-10" version="1">MIKHKLPGRRNAHMKVPGRSNRSGGSLGFTLIEMSVVLVVLGLLVGAFAPLIVSQLRQEKVSEAREVVRTARDEVVGFARMNQRLPTRSEFSTRIGHTIDPWNNELFYLPAAETTTEDENNESSALCQENSIQGLSLALPGRHDVEGVAFIIGSKGANQQSNTYFTSDDTNFTLITSRTDDGLDDEGVEGKVVIKRHGEEDQTGDKYDDLVEFVTLYYLNNRACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKS1</accession>
    <name>D6SKS1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868414.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2696"/>
    <dbReference type="EnsemblBacteria" id="EFI35282">
        <property type="protein sequence ID" value="EFI35282"/>
        <property type="gene ID" value="Dthio_PD2696"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="277"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="471" mass="53271" checksum="00DFF4F2217296AE" modified="2010-08-10" version="1">MYRQQVAFIITVLMVLDGLAVIVSGYGAMHLRRIAGGGVWFMEDYLLVGIILFVMFANNFVMGVMGLYSDKRHHSILPVIKRLTGSVIVVFACLGVALYTLKLFDIPRGFLAGFALLVLAGTVMNRVVLDIILDRIHCNGFSARRILIVGSGERAEKAHEALMEQKSWGHKVIGLINPDNGGVQGLPAVPLLGSMSDFFQVITEQGVDEVVFALNPEFGQDIKAYLDVCEKMGVSYKIIPAMYNPSSTYRLSVEHIQGIPTLTRELNGINATGLLYKRIVDYVFGIAGFCMLCLMYPFVATAIKLDSPGPVFFKQKRVGRNGRIFNIYKFRTMHVDAEERKRELEAGNEMNGFMFKMQNDPRITRVGRFLRRTSLDEFPQFINVIKGEMSLVGTRPPTLDEVRQYEPWHRRRISMKPGITGLWQVSGRNSINDFNQVVKLDLQYIDQWRFLNDLKIIVLTLWVVMKRKGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKX7</accession>
    <name>D6SKX7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyruvate carboxylase</fullName>
            <ecNumber evidence="2">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868470.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2753"/>
    <dbReference type="EnsemblBacteria" id="EFI35338">
        <property type="protein sequence ID" value="EFI35338"/>
        <property type="gene ID" value="Dthio_PD2753"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="14"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="132"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="539"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1227" mass="138093" checksum="0D8093D551665350" modified="2010-08-10" version="1">MEIKSFEQVVKELEGQKILVANRGIPARRIARSIREVFNAVPVMTATDVDKTAPFTSGAQELLLLGEDSRAYLDMKKIISKAKAMGVIAIHPGWGFISEDFSFPSQCRKSGLVFIGPEDRPMEILGNKVAVRDLAKRVDVPVVPGSEGAVTVEQALDMAYEIGFPVMLKAEGGGGGRGIYEVFREEELERAYAKASALAQASFGNPRLYVEKLLTSVRHIEIQVAADRHGNVFAFDERDCTLQRNHQKLVEITPSPWPVMNEDLRAKLKEYSRRLVSEVGYHSLCTVEFLVDREGNPYLIEVNTRLQVEHGITECRYGVDLVEEQIAMAFGSELRFNDKDTLPNNHSMQVRINCEDPQQDFAPNAGLITRYQSPGGQGVRVDSCISAGYHFPSQYDSAAALLIVYGRTWNKIVGTMERALNEYIVGGLKTTIPFHRRVMANAQFRSGEYDTNFVGQTPELMVYRDREPEALRLSKLVAEISARGYNPHVELGEYRGVHDKRLGRIQPVLPSLKHDDYQYPYPRGDRDAVLDYIRDSDHIHFTDTTTRDITQSNSGNRFRLAEDRLIGPYLDRCGFFSLENGGGAHFHVAMMANMTYPFSEAREWNHFAPNTLKQILIRSTNVLGYKPQPKNIMRLTGEMICEDYDVIRCFDFLNHIDNMLPFAQVAMSHKKNIFEPAISLSYAQGFDIKHYMGVVDEIVNLMSRATAMAHDKVLKKFILGLKDMAGVCPPWFIRELVSKIRTKYPELIVHYHRHYTDGLFVPAVAEAARAGAHIVDTGIGASVRWYGQGEVLSTAAYIEELGMKTNLNKDMIRQCGFVLKQIMPYYDKYTAPYFQGIDYDVVEHGMPGGATSSSQEGAMKQGYIHLLPYMLRFLAGIRKIVRYHDVTPGSQITWNTAFLSISNVYKEKGDKGVRHLLEVLDKVVSTPEKELDEQTKEDRLEIYKHSNDAFRNLLLGKFGRLPQGFPPDWVYESAFGENYRDAIASRTEDSPLANLEDIDVSKEENNLYTNIGRIPTREELVLYLNHPGDALKNIQLKCEYGDPNQLPLDVWFEGLLPGNEIFFEDTNGMPHFLAVLDISAPDINGMSVVRYSLDSEFFSHQVKVKEGMGAALDALEMADSRDPNQVGSPSTGDLWVMHVKPGDKVKKGEELFNISIMKQEKAVLSPVDGVVKRVLKFADFQGDKKMVPVKEGELLVELGPVPSTCPGCGDHIMLDDCKFCPECGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL48</accession>
    <name>D6SL48_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868541.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2825"/>
    <dbReference type="EnsemblBacteria" id="EFI35409">
        <property type="protein sequence ID" value="EFI35409"/>
        <property type="gene ID" value="Dthio_PD2825"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="356"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="574" mass="65161" checksum="3E5EFB43BCE1746C" modified="2010-08-10" version="1">MKAYFISMEHTSNNQNSAVKQQPRLSRLNPANWSLQNKFMLGSAVIMLMCCLVAAIAIYYHQKKELEAQALARSELVMAGVEASRKYVREELRPRMYELMGEDHFVREAMSTSYVGRAVMDRFAPELPGVRYRRVALNARNPEYEANIIEQDMIDYFRKNPEAEEWQGIVDHDGYAHFQRFKPVVFESECLHCHGRPEDAPRELLEMYGSEHGFGRSPGEIAGVVSIDMPVQEALSQVKERAVSVFVVVFVALSLIFAAMGILFNRIVITSLRGLLKDFQEATGTQPGDHGRDELGRLGAGFDSIMQELHDSRSKLQNWNRTLEEEIARVRQDLENTQERLVHNEKLAALGRLTANITHAIRNPLTAMGGFARRLEKTAQKDKEREYAGIILKEMRRLEEILNDIVVFSQDRCCTDFELHNPREVLQEYLEEHRDQITGQHIEVLFDIAPDLPRILMDRKKIHLILDNLISNSMHAMPQGGQIHITAGSSRAQNGQDLVKISLTDTGPGLPEQVLAVLFEPFTTTKDHSLGTGLGLPLCKKIMEEHDGWIEGENLPDKGAAFYLYFPLPPENQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLG7</accession>
    <name>D6SLG7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868660.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2952"/>
    <dbReference type="EnsemblBacteria" id="EFI35528">
        <property type="protein sequence ID" value="EFI35528"/>
        <property type="gene ID" value="Dthio_PD2952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8174" checksum="F80596FF26285EA2" modified="2010-08-10" version="1">MGEILIGILVMAGFIGFVIWKNKGKEQREETLDDLHREQWWADREDERKQGPVIVSADSRNDKDDKDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLM6</accession>
    <name>D6SLM6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868716.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3015"/>
    <dbReference type="EnsemblBacteria" id="EFI35587">
        <property type="protein sequence ID" value="EFI35587"/>
        <property type="gene ID" value="Dthio_PD3015"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033GEX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2085932at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15093" checksum="5F4A93F217FE3ADF" modified="2010-08-10" version="1">MLQQSAPATRPGLEEVKRQFEHWRETRHTRSPIPNHLWASAVSLAQDYSICKIAKVLHLNHSHLKKRVQAEQAQESLQPGPSFVEFELTSSLPCTEYHLETEARDGSKLKMQLKGPDLPNPLEILSAFWSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLW6</accession>
    <name>D6SLW6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868806.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3106"/>
    <dbReference type="EnsemblBacteria" id="EFI35677">
        <property type="protein sequence ID" value="EFI35677"/>
        <property type="gene ID" value="Dthio_PD3106"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893707at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="254" mass="30174" checksum="E7916A18ADCFAECE" modified="2010-08-10" version="1">MIIYSWNVNGFRAVTGKGFWDWFQDRNIDVLCLQETKAHPDQLPAKDKEVSGYNIYWNPARIKKGYSGTACFYRLEPQYISTGLPQEHLNGEGRMILMEYESFYLFNVYFPNGQMSHERLKFKLNYYDRFLEYAQDLRRKKPIVVCGDFNTAHKDIDLKNPRANEDRSGFLPVERQWLDKFIDHGYVDTFRMFNQEGGNYTWWTYRFGARSRNAGWRIDYFFVSEELRSNVQNAWIEPQVMGSDHCPVGLKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM33</accession>
    <name>D6SM33_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868873.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3173"/>
    <dbReference type="EnsemblBacteria" id="EFI35744">
        <property type="protein sequence ID" value="EFI35744"/>
        <property type="gene ID" value="Dthio_PD3173"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="593" mass="66573" checksum="FDE50D46CB99B93C" modified="2010-08-10" version="1">MEIDTTWVWVFLSLYIIYCFSWGLKGFFTEKTSYGYSIGGRQIPMIAFLMAATAASFSGWTTIGHPGLIWQYGLAYGFVSFYALTIPLTGSFFAKRAWLMGKRYGFVTPGDMYAYYYNREGVRWLAVLTAILFGIFYAAIQLMAAGALFHWVTGFPLSWGAILMAFIVWFYVVTGGLKASTWVGVVQFILLMVAMLTVGAYVLVHFGGWSHMSQEIQNMPDKFLEIPSIMEFTVGQEKWTALMILTYLFSLMGIQSSPAFTMWQFANKNPRPFAWQQVFMSAFLVGFAMFFFTAFQGLGGQILDMQGLIDPARDSDVVPMLMAKFLPPFVLGICFIGLIAAMHSTAAPYIGTAGSMLLRDVWWLKIRNKQGGHAEQIWMNRLFVTILTILALIVGLTSQAALVILGALATALGFIMYIPLMGTLWGFRWPSIGTVLGILAGLIAVFITYYVFPNPLTIHCAAWGIGTGLLVAYLSRFLGGTDNQATMDRQKEVRSWLDNIEEPGPRGRTWRNSMKYIIPVWFLFAAGPLAMMSNWGLFSFAGFPAAWSWQIVWWILGIIMMWALCFKAEMATITNDQIRRAETESKIVVHEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM80</accession>
    <name>D6SM80_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868920.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3226"/>
    <dbReference type="EnsemblBacteria" id="EFI35791">
        <property type="protein sequence ID" value="EFI35791"/>
        <property type="gene ID" value="Dthio_PD3226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1148398at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016041">
        <property type="entry name" value="Ac-CoA_synth_d_su_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03599">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdhD" evidence="1">
        <location>
            <begin position="16"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="315" mass="34193" checksum="ED6679CA09CD240C" modified="2010-08-10" version="1">MSYSAPIDRYTGKINKVEIGTGDASVQVGGETTLPFYLFEGEMPNRPRLAMEVCDEAPGDWAKALEDVLGDVWDDPVKWAAKCKDEFGADLICLRLLSIDPNGADKGPDEALEVVRKVADSVEIPLIIYGCGNASKDGEVLKKVAEQMEGRAMVLGPAVEENYKTISAAAMGFGHNVAGETPIDVNMAKQLNILMTNLGMPAERILIDPSTGALGYGLEYTYSVIERDRLTALQQNDAMMQMPIICDMGREAWKAKEAKVGTDEHPEYGDPVKRGIMWEAIGVTSLLVAGADIVVVRHPETVKLMRSTMEGLGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMB6</accession>
    <name>D6SMB6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868956.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3263"/>
    <dbReference type="EnsemblBacteria" id="EFI35827">
        <property type="protein sequence ID" value="EFI35827"/>
        <property type="gene ID" value="Dthio_PD3263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="517836at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025841">
        <property type="entry name" value="CP_ATPgrasp_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016450">
        <property type="entry name" value="UCP005522"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14403">
        <property type="entry name" value="CP_ATPgrasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005522">
        <property type="entry name" value="UCP005522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="482" mass="54179" checksum="55F95D1F109DDCDE" modified="2010-08-10" version="1">MLTALEQNFRNYDPGPYYDEMFESFQRPRPGCRVLLDKLESLSFQEIQAMQAAAKQSFFDQGITFAVYGEGQGSERIIPFDMVPRIIEAREWAALEQGLKQRIYALNLFLDDIYNEQKIIRDKIIPREVIETSAGYNPKCLGLKPPQGVWCHISGTDLIRDQNGIFMVLEDNLRTPSGVSYVLANRQVMKNILPAAFSESRVRPVENYPSLLLDMLYSIAPASDHVPNVALLTPGIYNAAFYEHSYLAQQAGMALVEGADLVMLDGYVHMRTTHGLVRVDVIYRRIDDEFLDPLCFRGDSLLGVPGIMEAYRNFQVAIANAPGTGVADDKVVYSYVPEIIKYYLDEDPVIPNVPTYLCREPGQMHHVLSSLQHFVVKPANESGGYGMLVGPDSSREERENFAARIQQSPRNYIAQPVISLSRSPVIVNDRFEGRHVDLRPYILYGQDIQVVPGLTRVALKENSLVVNSSQGGGSKDTWVLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMF1</accession>
    <name>D6SMF1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bifunctional enzyme IspD/IspF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
                <ecNumber evidence="14">2.7.7.60</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">MEP cytidylyltransferase</fullName>
                <shortName evidence="14">MCT</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
                <shortName evidence="14">MECDP-synthase</shortName>
                <shortName evidence="14">MECPP-synthase</shortName>
                <shortName evidence="14">MECPS</shortName>
                <ecNumber evidence="14">4.6.1.12</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">ispDF</name>
        <name evidence="16" type="ORF">Dthio_PD3301</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 14">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IspF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the IspF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="14"/>
    <dbReference type="EC" id="4.6.1.12" evidence="14"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868991.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3301"/>
    <dbReference type="EnsemblBacteria" id="EFI35862">
        <property type="protein sequence ID" value="EFI35862"/>
        <property type="gene ID" value="Dthio_PD3301"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01520">
        <property type="entry name" value="IspDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026596">
        <property type="entry name" value="IspD/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9 14 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YgbB" evidence="15">
        <location>
            <begin position="238"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" evidence="14">
        <location>
            <begin position="237"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="14">
        <location>
            <begin position="243"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="14">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="14">
        <location>
            <begin position="296"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="14">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="14">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="14">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI35862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="398" mass="42973" checksum="FB26A5AD9F6D3BEA" modified="2010-08-10" version="1">MNIWAVLLAAGKSSRLQNQGQVQKKQFLKYHGLPLFWHSVQTFARNPQIKGLVAAFPAKDLQQSQSEVRDLQKKRDPGIALVCVGGGALRQNSVFNAMQALPPECTHVLVHDAARPFFSPRLITSLIREFSPGLGGVIPGIECKDTIKELDGDQVLKTLPRDRLTAVQTPQFFSMQALRDAHQQALKQDFTATDDASMLEECGYRVKVIPGEEKNIKITTSEDLQVLASQEKSALPCTGLGYDVHRYGGDRPMILGGQPIPGAPGIHAHSDGDVLVHALVDAILGCLGKGDIGDLFPDTDPANENLSSMVFLSEVLAMAQAEKLELVHIDITIIAQKPKLGPHKSSIRSNLAGITGIDPGRINIKATTEEGLGFTGSGQGIKAMALVSALRHKQESAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMI1</accession>
    <name>D6SMI1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869021.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3331"/>
    <dbReference type="EnsemblBacteria" id="EFI35892">
        <property type="protein sequence ID" value="EFI35892"/>
        <property type="gene ID" value="Dthio_PD3331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="665169at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027591">
        <property type="entry name" value="CofD-rel_GAK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04357">
        <property type="entry name" value="CofD_rel_GAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="402" mass="45435" checksum="B3C869428A977E76" modified="2010-08-10" version="1">MPSESAHKIHICRTVSLPDPVKLTRYLKVPEFGPRILFFSGGTALNPLSRALVRYTHNSIHLVTPFDSGGSSAKLRNTFKMPAVGDMRSRLMALADQSVKGNPEIYNLFAYRLPKDEDREKLKSILMRMADGHHPLVRSIHDPMRKIVCSYITAFARKMPEDFDLRGASMGNLILAAGYFSHNRHIDPVIFLFSKLAEVRGMVRPIMNKYLHLVSRLENGEILLGQHELTGKETPAIESPVQEIYLSSSLKKPAPIYPRLKEKVRRLIQDAELICYPMGSFYSSLMANLLPRDAGSAIARNECPKIYIPNTGHDPEEKGTNLRQRVEILLYYLHQSAGKKHKDSQLLNFVLLDKDHELYKGGVDVSGIERLGVKVIEAPLVDPENRPFLNADFLLERLLSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMR0</accession>
    <name>D6SMR0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="7" type="ORF">Dthio_PD3413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869099.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3413"/>
    <dbReference type="EnsemblBacteria" id="EFI35971">
        <property type="protein sequence ID" value="EFI35971"/>
        <property type="gene ID" value="Dthio_PD3413"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="9689" checksum="CF97BB882B8716BC" modified="2010-08-10" version="1">MAHKKAGGSSRNGRDSHGQRRGVKRYGGQKVRAGNILVRQLGTKIHPGANVGVGKDYTLFALSDGEVKYDKFTRKKKVRTRVSIVPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMT8</accession>
    <name>D6SMT8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrose synthase</fullName>
            <ecNumber evidence="3">2.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + H(+) + sucrose</text>
            <dbReference type="Rhea" id="RHEA:16241"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:76533"/>
            <dbReference type="EC" id="2.4.1.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869127.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3441"/>
    <dbReference type="EnsemblBacteria" id="EFI35999">
        <property type="protein sequence ID" value="EFI35999"/>
        <property type="gene ID" value="Dthio_PD3441"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016157">
        <property type="term" value="F:sucrose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000368">
        <property type="entry name" value="Sucrose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012820">
        <property type="entry name" value="Sucrose_synthase_pln/cyn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45839">
        <property type="entry name" value="PTHR45839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00862">
        <property type="entry name" value="Sucrose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02470">
        <property type="entry name" value="sucr_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sucrose_synth" evidence="8">
        <location>
            <begin position="14"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="7">
        <location>
            <begin position="558"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="793" mass="92373" checksum="0B48D6146A1327A3" modified="2010-08-10" version="1">MIDVEELDGLDPELRKSLYLFLREMIRKEKPFLLRSELQDMLADFFEDEEHGRHESALVFEVFRYTQVATIRNPWVYLAVRPEIAKWQYFRFHVEDVLFDEIGASDYLKFDEMQVNNSTQVDEFLLEIDLEPFNREFPKLNEYTYIGKGVDFLNRHLSGQFFQDKKRGHEKLFEFLRLHQIEGKQLMLNGHIETVSGLRSALRKALTFLKKQDPSQKWSGISRHMQTLGFQPGWGKDVERVRENLELLREILEAPTPNILASFLSRIPMIFKLVIVSPHGYFGQSNVLGRPDTGGQIVYILDQVRALEKEMRRQIKEQGLEIEPEIVVLTRQIPEAGDTTCNQRQEDIVGTSNARILRVPFRYPSGEIVPHWISRFHVWPFLERFALDSTQEVHSELKGRPDLIIGNYSDGNLVASLMSKKMNITQCNIAHALEKSKYLFSSQYWKDNEAQYRFSSQFTADLIAMNTADFIITSTYQEIAGTEESVGQYETYNAFTMPDLYRVVSGIDVFDPKFNVVSPGADENVYFPYYEKDRRLTELHDELSDYIYGPPGDWAKGELQDRTKPILFTMARLDRIKNLTSLVRWYGENPELRQEANLVLVAGSLDVRDSQDEEEKACIQEMHRLFEEFDLHEQVRWLGTRLDKNMSGELYRFIADSRGAFVQPALFEAFGLTVVEAMNSGLPTFATIFGGPLEIIEDGKSGFHIDPTHGDEAAGLMANFFSRCRADASYWDTISNNSIKRVEEKYNWRLYAQRLLSFSRIYGFWKYVSNLERDETRRYLDMFYSLKMRSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMU2</accession>
    <name>D6SMU2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="8" type="ORF">Dthio_PD3445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3445"/>
    <dbReference type="EnsemblBacteria" id="EFI36003">
        <property type="protein sequence ID" value="EFI36003"/>
        <property type="gene ID" value="Dthio_PD3445"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="36"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="344" mass="38744" checksum="B23C326528B849CA" modified="2010-08-10" version="1">MRYSKIQDLPTKWAHFCLNISSFVHRQAGVSLKGKKVLAGFSGGPDSAALVLAMHYLAPSLNMKLEAAYLDHGLRREAGEDLALVQDTCSQLSMKLHLGRSNVSRLAGRGRGGIEETARRLRYRYLHGVARKTGADYVLTGHHLNDLAEDILMRLQRGTGWPGLSGMRAYVPERRILRPLLMIPRKCIMDFLETAGQGYVLDATNKDKTFLRNRVRMSLVPEFEAINPGFLKSIANIWRLGRVDADYWDHILEEARQDVQEEDLVPGDLLSGMHQAARMRLYKKTLDSLGPGQALVENIFKLDELWQSRKTGARVQFPGDKEALISREGIEFRHISHGTEKKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMW7</accession>
    <name>D6SMW7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869156.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3470"/>
    <dbReference type="EnsemblBacteria" id="EFI36028">
        <property type="protein sequence ID" value="EFI36028"/>
        <property type="gene ID" value="Dthio_PD3470"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="220" mass="24349" checksum="0A73C0289208F648" modified="2010-08-10" version="1">MYSKSSLKVLILAIILLAGLYLQQSGIIDLSREIARAESLAELWWAPVVFIFAMGSLYTIAMPAAFFIWILGVIYHPWPATLMVIAGGALGSIGAYYFTGYLSTAVREKFARTQAFSLLRKNSGFFQLLAMRSLPGFPHVLINFSCGILQIPLAAYIYSTILGFAFKGYIYTTAVHNATHHVHESGNNIVSFQTVWPLLLLVVFSLGGIFIQKKILKNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN03</accession>
    <name>D6SN03_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869192.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3508"/>
    <dbReference type="EnsemblBacteria" id="EFI36064">
        <property type="protein sequence ID" value="EFI36064"/>
        <property type="gene ID" value="Dthio_PD3508"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="775" mass="88958" checksum="FB8EA458E542913E" modified="2010-08-10" version="1">MSDFCHLHCHTEYSLFEGCIRIEDLCSRAVEYKMPAVSITDSGNLFGAMKLYLKAREYGIKPIIGCEVNLSPEKITDRDSFNYHLVLLAMDLHGYHNLVRLVSAGWMQGFYYKPRVDKDMLQTYSNGLIALSACMEGEVQYLLRTKGFDHALEAARQYASIFPDRFYLELEASGLKDQAEVNGRLMEMSEKTGLPMVATNDCRYLAPQDAEAYAALRCIQKNERLDHHNLNSRELYFKSPEEMEKEFSHCPTALENVQKIIEQCGLDLEYPKRHLPKYTPSAEDTLDKELVALSEKGLEEKLANLPYEVDRDEYFTRLDKELKVICEQGESWYFLVVHDYVSWAKSRGIVVGPGRGFAPGSMTAYALGITGVDPIRHRLYFEKFFNTKTGLKDIDVDFCHERREEVFEYLREKYGQANAVYPSVFVASKARVVLRDVGQVMGFSLDQVEQITSLIPEKIGITVSKALEMEPALRNLMNDNEEMQRYLDICKRLDRLVRHVSIHAAGIVISNEKLQSYLPLYSDQNKAIVSQYDWDDLRRLGFIKFDFLGLKYLSLISRTLALIKVNKKQVPDMENLPLDDTLTFDLLDGGLTEGVFQLESSGMRNTLMDLTPTCFEDIIALHAIYRPAFLQNGIDKDFIKRKHGLVSVEYPHPDLEPILNETHGLIIYQEQLMEIAQTLAGYSLEEGDTLRRVLGKKEATTMAEQREKFIQKARDKGLDQLTAKHVFELMERFASYTFSKSHSVAYSMIAYQTAYLKAHYPEEFQRALSMVFNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN66</accession>
    <name>D6SN66_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1541</name>
        <name evidence="3" type="ORF">Dthio_PD1544</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869522.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1541"/>
    <dbReference type="EnsemblBacteria" id="EFI34192">
        <property type="protein sequence ID" value="EFI34192"/>
        <property type="gene ID" value="Dthio_PD1541"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34195">
        <property type="protein sequence ID" value="EFI34195"/>
        <property type="gene ID" value="Dthio_PD1544"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="304" mass="35828" checksum="63EFE04D3E509783" modified="2010-08-10" version="1">MPRNARFTLPDRPTVYHVISRTALPGFPLGDIEKDKLLDIIRYFSKIYFVDVLGFAVMGNHWHLAVRVYPQEYAERDEVKERFSDRYGDDIYFGDKEYEKCSKKWTDLSEFVREIKQSFSRYYNKRHSRRGFFWGERFKSMIVQEGRTLVNMLAYIDLNPIRAGIVKKPEDYRWCSLGYHTQTGNKDGLLSIDFGMKEWNEFNPSEIVRKYRQFVYETGAVDAGKGKVMDRKIVEKARKKGYKISRTDRFRYKCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDERKFTPVGGVDGVYSMKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN70</accession>
    <name>D6SN70_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0164</name>
        <name evidence="5" type="ORF">Dthio_PD1546</name>
        <name evidence="6" type="ORF">Dthio_PD2144</name>
        <name evidence="7" type="ORF">Dthio_PD2202</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869525.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0164"/>
    <dbReference type="EnsemblBacteria" id="EFI32857">
        <property type="protein sequence ID" value="EFI32857"/>
        <property type="gene ID" value="Dthio_PD0164"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34196">
        <property type="protein sequence ID" value="EFI34196"/>
        <property type="gene ID" value="Dthio_PD1546"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34768">
        <property type="protein sequence ID" value="EFI34768"/>
        <property type="gene ID" value="Dthio_PD2144"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34817">
        <property type="protein sequence ID" value="EFI34817"/>
        <property type="gene ID" value="Dthio_PD2202"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="362657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017895">
        <property type="entry name" value="HTH_IS408/IS1162_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50532">
        <property type="entry name" value="HTH_IS408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH IS408-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="136"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="515" mass="60026" checksum="437F01AD5D6D6C5C" modified="2010-08-10" version="1">MPQERLSMRKISEILRLKYGQGFSTRQIAKCCDIGKSTVATYISRAKNAGIFWPLPENMTEERLHELLFPPQQNEHKVSTPVPDWNLVHQEMQKKGVTKFLLWEEYKEANPDGFEYSWFCREYRAWRGKLDLVMRHNHRAGEKLFVDYAGHTVPVTDPGTGEISQAQIFVAVMGASNYTYAEATWSQNLWDWINSHVRTFKFLQGVPLITIPDNLKSGVNKPHIYEPDLNPTYQDMALHYNTAVIPARRKKPKDKAKAESGVLLVSRWILARLRNQQFFSLWELNLEIRKLLEKLNDKPFKKLPGSRKSLFEEIDRPALQPLPATHYEYALWKKVKVNIDYHVEIDRHYYSVPHHLVKKRLDARYTENTVELFHKNSRVASHKRSYNKRSYTTVKEHMPKAHREHDYWNPERLINWASKTGPATAKLIKTIMGKRIHPQQGFRPCLGVMRLGKQYGEERLESACLRALTLGSTNYKSVESILKNNLDKQPLPSPSENSEAPVLEHDNIRGANYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN80</accession>
    <name>D6SN80_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869534.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1557"/>
    <dbReference type="EnsemblBacteria" id="EFI34206">
        <property type="protein sequence ID" value="EFI34206"/>
        <property type="gene ID" value="Dthio_PD1557"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005046">
        <property type="entry name" value="DUF285"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011889">
        <property type="entry name" value="Liste_lipo_26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03382">
        <property type="entry name" value="DUF285"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02167">
        <property type="entry name" value="Liste_lipo_26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="536"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1234" mass="137668" checksum="6153435972D5B477" modified="2010-08-10" version="1">MSIQFNQDLEITLGTPFTDLFANTDEEQTSWYRLWTGKLDNEGEVVRGAMVGGGWVSKDGLEDLTVGVDQAGHNTLYVQTYTDEVNAWEHSTQMNFPEEIPFELAIEKDVVSEDTMLSDMFSFDTPVSSNEVWFQVKVDEEPVDTALGHGWVRGDRLGDEYFTAEHGGKELEVTPFYAGELHTDKARTQMVDRAEHYELSIDKAYVEEDTPLSEMFSYNLPTGFTADTIWFQVKVDGEPIDTALGNGWVRGDRLGDEYFFAEDTGKKLNVTPFFDGELQEVLSQEWTVHEELAELEINFMNVTPEEPEAGEEFSVDVNLEELAGIETEDLTVSLAIAGTGIEETIEVDSLQGSEDTVTFDNLVIEDTGEYTIDVTADAGNADAVSSRITLSLEDFVDGIEITTQPDLEYTEGQELDLSDLVVTKSYQEADDRTVAFSDFADYGLTAEPGDGTGLSLEDDGQTIEVEHSPTENTAETQPLSVSMQEVENHFPTDYEQYMITLINRARLDPEAEADLFGIDLNQDISPEDEISPDMKQPLAFNPDLTQAAREHSQWMLDNDTFDHTGEGGSSVEDRIKDTDYNTDPPWGWGENLALTGYTEGMDELIAQKHENLFHSSGHRENTMRESFMEVGVGSLLGDYTGDTGYMTTVKFAHTSDTPFLTGTVFQDLDGSGAYKPGEGLGDVQVQAGEQVTATWDSGGYAMQLEPGDYLLTFNHDEFEEKVEMDFTMPDENVLVDLVLEPDDLQNQTDSSDLSIQSIVITPEEPEAGQEFTVDVSIEELAGVETENLTVNLEINDTDIDETKYVDPLQETETTVSFEDLVIYEVGEYIIEVTTDADNASQATQTKEFAILEEDASQFLTVTEEQLRGAASGLIDGDGSFAIVHEDIEYTFEDSEYNIDTSQVADMSGIFAGTDFNGDIGYWDVSNVDDMRSMFFLAESFNQDIGDWDVSNVQSMSSMFSEAGSFNQDIGDWVAPNVQDMSSMFVGARNFNQNIGDWDVSNVDDMKAMFLGAEAFNQDIGDWEVSNVTNMKKLFENAGSFNQDLGDWETSSVQDMSYMFQDAESFDQDIVRWDVFKVQDMRAMFWGAETFDQDIGEWETSSVQDMSYMFRSAESFNPESFNQGIGGWDVSNVDDMRSMFDGAKSFNQNIGDWDVSNVQDMNMMFAGASSFYQDISGWHVPHIPEEPFGFAGGSPLAENEHLHPWGDEDDEGNSQAIEFMGLEKEKDILGDGEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN81</accession>
    <name>D6SN81_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34207">
        <property type="protein sequence ID" value="EFI34207"/>
        <property type="gene ID" value="Dthio_PD1558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="37" mass="4090" checksum="5F7FD5708627FE31" modified="2010-08-10" version="1">MPGFQPLTRKDHAESVPAPLQSAELASVEHIEGRQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNA6</accession>
    <name>D6SNA6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869560.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34232">
        <property type="protein sequence ID" value="EFI34232"/>
        <property type="gene ID" value="Dthio_PD1583"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031KXS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1981116at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="13875" checksum="A4349DE3DBBC21F0" modified="2010-08-10" version="1">MTRAASIINLYDSLLAAEDERARARIIAEAFESLEDRYPELKDLATASGLRETELRLQKEIEQTRLRIEEVRSELIREIEKLRSETSKEISAGNQKIIRWTTGLLFAQLVAIIAVIIGVGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNB2</accession>
    <name>D6SNB2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1589"/>
    <dbReference type="EnsemblBacteria" id="EFI34238">
        <property type="protein sequence ID" value="EFI34238"/>
        <property type="gene ID" value="Dthio_PD1589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="52" mass="5720" checksum="5467A62C5989F173" modified="2010-08-10" version="1">MKKGLPHQAGSLLFIYTGSVDMDIIPFPLVFSSSSLALRLKGRFGPGVRYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNC6</accession>
    <name>D6SNC6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869580.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1603"/>
    <dbReference type="EnsemblBacteria" id="EFI34252">
        <property type="protein sequence ID" value="EFI34252"/>
        <property type="gene ID" value="Dthio_PD1603"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047578at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="121" mass="13812" checksum="935430C8AEC85E59" modified="2010-08-10" version="1">MQERKRHGCLTIWLVVVIGANFLDAFRHYLMRDELMEQFPGTPEWVITGLFILALVNVACGIALFRWKKWGFWVLLLSSLAGAYLYLQLSFVNALVPLLVVAVLFGALHIGGERKGWHQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNC7</accession>
    <name>D6SNC7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869581.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1604"/>
    <dbReference type="EnsemblBacteria" id="EFI34253">
        <property type="protein sequence ID" value="EFI34253"/>
        <property type="gene ID" value="Dthio_PD1604"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="411"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="621" mass="70201" checksum="1066084459F84DF2" modified="2010-08-10" version="1">MNKKLLFPGVLLLAILYTAIGGLAYNAGQELEGVVTQQFNDQQLILAEKIADDIRGHFQFLETALATLSRQTVKILPEQPSHDYLHSTHDILKDWHVLSLGIAGNAPDNSLMAPDGSVSSWKDMGIDFPREEFQLWLDSDPDGQVFFSRTFRPDQGPYAGTWIMVMVKPLSRDLEMSFESGNFEGMPPAAFFVVDAMKVSRDYAHGVISGQTGYPWVINEEGYFLYHIEDDFDGRDSFTVRHERNPDISYERINTIVSQRLLAGDEGTDWYISGWHREVYTEMKKLLAFSPVFFTHQEKKRDSHLWSVGVAAPDEEVWGLIQPIVVRQWVVAGLFLVGATLGLFGLYFLSLRWNHVLTRKVEDKTRHLMESREQLREEKEKVEQSMQKLKDTQQRLVQSERFAAIGEAASHMSHEIKNPLMLMAGFAGQVRRRLSEDSPEAEKLDIIVNEAKRLEKMLVEVRDFTRPHKLSIKPCQPNDLIAETVKIFQDSLESSGIVCSQELSTDLTQVNMDPDQVKQVLVNLIKNAVEVMPEGGTLGISSKRQNQWVVVSVQDSGPGIPAEKLKNIFSPFYTTKDKGTGLGLAVSYRIIQDHGGDIFVDSQEGHGARFTIYLPLEEANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNI6</accession>
    <name>D6SNI6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869640.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1663"/>
    <dbReference type="EnsemblBacteria" id="EFI34312">
        <property type="protein sequence ID" value="EFI34312"/>
        <property type="gene ID" value="Dthio_PD1663"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="149"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="418" mass="45813" checksum="08D3A08DA7A77D81" modified="2010-08-10" version="1">MGLLSVDELKPGMVLERDVLAPNGRLLLGTGTELTPRNITVLKTWGVVDAHVQGDGQEHNSHQEPTLTRELLDHTRQQLQPFFACTDLSLPAMREIFKLALYQAAGQGKGHFVLPPSCNTGDQAPDPEKILAGHPLVTAADIIGEQTRLATFPDIYHQINAVLQSPRSSATHIAKVVGKDASLSGKLLRLVNSPFYGFPRKIDTIPRAVAILGTNELSTLALGISVVHYFSGIPEGSVDMKSFWRHSIACGVLSRLLADKQQGLSEETFFVAGLTHDIGRLVMFNHLPGPCGEILEFAARAGMPLFQAESRVLGFDHALLGGELLKKWHFPISLENPVRFHHQPCSALNILDPSIVHVADILVQALDFGSSGNLFVPPLNSTAWQELKMNKTVFTWVKSMALRQVYEIERIFLGGTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNK4</accession>
    <name>D6SNK4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRAP dicarboxylate transporter, DctP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869658.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1681"/>
    <dbReference type="EnsemblBacteria" id="EFI34330">
        <property type="protein sequence ID" value="EFI34330"/>
        <property type="gene ID" value="Dthio_PD1681"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00787">
        <property type="entry name" value="dctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088126" evidence="3">
        <location>
            <begin position="20"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="37380" checksum="DC186841F5F8E55C" modified="2010-08-10" version="1">MKKVLACLFSAVLMVVATACFTLKEPDLAQASTEIRLAHVVNEEDSFHIAAMKFKEIVEERTDGEISISIYPNAQLGDERNLLEGMRMGTVDMGVITNGPVANFVEEIAVLELPFLFPSREDAYDILDGPIGSELLDNLKRVNLKGLAYAERGFRNLTNSKRPVHTPEDVSGLKIRVMENPVYIDTFRALGANAVPMAWTEALTAMRQGTIDGQENPVNVIHAFKLDEQQDYLSMTRHTYAPAIFVMGQMNWQGLSPEQQEIFVEAAQEASEHARQVNFEMEEEQLQELQERGMQVIEEPDLEAFRSEVHSVYDKYGDDFGEYLERILDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNP3</accession>
    <name>D6SNP3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34369">
        <property type="protein sequence ID" value="EFI34369"/>
        <property type="gene ID" value="Dthio_PD1720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="36" mass="4060" checksum="5D095231683B8410" modified="2010-08-10" version="1">MIIINKTPEIELHLSQAHILMPEKTVTALKGEFSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNP6</accession>
    <name>D6SNP6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1724"/>
    <dbReference type="EnsemblBacteria" id="EFI34372">
        <property type="protein sequence ID" value="EFI34372"/>
        <property type="gene ID" value="Dthio_PD1724"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="6">
        <location>
            <begin position="370"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="6">
        <location>
            <begin position="481"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="610" mass="67533" checksum="92A71499014A8B8D" modified="2010-08-10" version="1">MSKNLTKLLILAVIASIVAAYFLLDIHAHLTLDNIRASRAEFETLLEERFLTVLGIYLLVYMVVVSLSLPGALPLGLLAGAMFGAITGTIIVSFASTIGATMACFLSRYLLRDWVKSRFSGFIEAVDRGVQKEGALYLFTMRMIPVIPFFIINLAMGITSIRLRTFFWVSQLGMLPGTFVFVNAGSHLGRIQSTEDIFSPGLIISLALIGILPLAAKKIVGILKKKYGSQEDHSELSVPVTNPAVSFAPQGMPSESLIHLAEANQQGCSRCEVCVSQCEFLKKYGMPGDIAQGILDGKNSTDPFECSLCDLCGAICPEKLSPADMFLDMRRQAVQEETVDLSRYSPLLKFEKLGHSNLLSRYPAQKAHTVFFPGCALPGTRPEITWRIYQELKKALPSLDMVLDCCHKPSHDLGRDDFFHKNLQEIMGKLRDLEVKEILVACPNCFKVLNAYAEDFKVKTVYQVMAEENSFQEVEKPGRLAVHDPCPLRYQDGIQDAVRRLLKARGIEISKMKNSGKKTLCCGEGGAVGFHNPGFARTWSLKRKKRAGQDMMVTYCAGCAGFLSRQGPTIHLADVLFEPEKALAGKSRVSRTPMTYLNRILLKRRLGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNY6</accession>
    <name>D6SNY6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="3 9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tig</name>
        <name evidence="12" type="ORF">Dthio_PD1821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869784.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1821"/>
    <dbReference type="EnsemblBacteria" id="EFI34462">
        <property type="protein sequence ID" value="EFI34462"/>
        <property type="gene ID" value="Dthio_PD1821"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_N" evidence="10">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Trigger_C" evidence="11">
        <location>
            <begin position="263"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="442" mass="49815" checksum="32080A52C311E7A5" modified="2010-08-10" version="1">MEYTVEDISPVKKKINIQVPTEEVHAALSAATAMYSRDVELKGFRKGKVPASVVEGRFKKQIYNEATTDLINVHINQIMSEMKFNPLSRIDVDAGLLEREKDFNYSVSFEVAPEFELPPYKGITIEEEEVLVNAEEVDQVINRIRNNMAELVVIDEERPPRDNEAVVIDFEAFDNGKPIEGVKADNFQMTLGEGGALPEFEELIKELKPGETGSREIPLPDDFLNEELAGRPVLMQVTLHSIKEKKLPDVDDELAQKAGGFDSVEKLREVIEQSYKSTRKELHKSSAQKKALDELKARVEFELPESLVQGRIQQKISDLQSQMEKKGKSLDSLGKSREELEEQFRPEAEDMAKSQLFLLAVARAEGLDVSEDEMDAYIQKQAQSGGQDPAQLKKFYQDNNLMFALKDSLLADKAMDFIYENAQVNLIPPQESEEGGQETASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP10</accession>
    <name>D6SP10_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869808.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1845"/>
    <dbReference type="EnsemblBacteria" id="EFI34486">
        <property type="protein sequence ID" value="EFI34486"/>
        <property type="gene ID" value="Dthio_PD1845"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1239195at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="138"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="202"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="459" mass="50723" checksum="338BEEC89742189D" modified="2010-08-10" version="1">MSSLMENITAMLENKEMNRLKEVLNQQEHYDLVEFFSELEAQGKRDELAILFRLLNKDLSLVVFEDLSLETQETLIQHLAGNWAVEIITEMEPDDRARLLDEVPAKVAKQLLNSIPADERKKTADLLNYPAETAGRIMTPEYVSLKADMSAEEALERIRSKRKSAETIYVLYVTDAKRRLLGVLSLGDLVTADKASRIRDIMNEKVIKVHTETDQEEAAVLLKERDLLAVPVVDREERLVGIITVDDAMDILEEETTEDIMSKAGLGTLTRQETGRSQRLIEGPVWDVWKVRLPFLVITLIGGMLAGAVIDAYEATLEAIAAVAIFIPVIMDMGGNAGTQSSTIFTRAFVLGHISVKRFGYHLTREAGIGLSMGAMMGLVAGIIASVWQGEPSFGLAVGISLALTMTLATALGFLIPFILVRLGMDQAAGSDPFITTIKDISGLFIYFTFVSIFLGHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP16</accession>
    <name>D6SP16_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869814.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1851"/>
    <dbReference type="EnsemblBacteria" id="EFI34492">
        <property type="protein sequence ID" value="EFI34492"/>
        <property type="gene ID" value="Dthio_PD1851"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="703"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="28"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="295"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="688"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="787" mass="86867" checksum="B98A1D919E54122B" modified="2010-08-10" version="1">MVRAINRKLFRDLWELKGQVAAISVVLGAGVMVLILAVTILDAVNLSKDRFYQTHNFAHIFCDLKRAPEFVSSRLEEIPGVSAVQTRVAAPVRLEVPAFDDPVRGRVLSIPNGDQPRLNRLYLRRGSLPEPDQPGQAVISEPLAQAHSLKPGDELRAIIRGRLETLTISGVALSPEFVYQLGPADLIPDYERFGVLWMNRRDLEAAFDMQGAFNSVLVSLQSGAHEASVLDALDEILAPYGGVGAYGREDQVSHRFLQDELDQLRVMAVVLPLIFLGVAAFLLSVLLSRIISTQRRQIAVLKAFGYTNQEIGLHYILFSGLIVTSGCILGVGLGLWAAGELAALYGEYFRFPELIFRLSPRILALAVFVALAAALLGIFRAVRGAVSSPPAEAMRPPAPEKFSLGSFQGPVWNRILDQTGRIILRNLARKRFKALMSVLGIALSGSLLLLGSYQFGSVDHMLDTQYRLVQKMDVHLVFTESVHEQSSRELEVLPGVLFVETYRSVPVRLKHGQRDYRTSIMGMEQKPALRGILDQDFSQVKLPLQGLVLTDYLAGHLGVEPGDTLQVEIMEGRRRNVEMEVARLVQEPIGVGAYMERRALNRVMGEGPAVSGAWLLTDHTRHFELYEHLWDTPAIAGIGVTSQAEVNIRSYIQDTALGFMAVLLVMAGSIAFAVVYNNARIAYEERYRELATLRVLGMTRVEVGWILVGEILVVTLAAIPLGWLLGAGFAYGLNQALSTDFFRLPFVLQPGVFAFSAAGVLLATFLSVLLILRRLLRLDMVEALKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP50</accession>
    <name>D6SP50_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative type I restriction enzyme, S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869846.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1895"/>
    <dbReference type="EnsemblBacteria" id="EFI34526">
        <property type="protein sequence ID" value="EFI34526"/>
        <property type="gene ID" value="Dthio_PD1895"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="827072at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="460" mass="52944" checksum="7A2B278E5ED5EBDC" modified="2010-08-10" version="1">MIDELKPYAEYKDSGLPWASKIPTHWKVRRAKNLFRCIDVRSKTGTEERLTVSAERGVVPRSSMKVTMFEAKSYIGHKRCWPDDLVINSLWAWGRGLGVARHHGLVSSAYGVYRLRPEFDEYAPFIHHLVRSKVYHWELRTRSKGVWISRLQLTDDAFLRAPILVPSVEEGKAITRFIRDIDRKVNAFIRNRRRLIKVLNEQKQAIINRAVTRGLDPNVPLKPSGVDWLGNIPKHWEKNRLKFLVRNVNEQTSTRQPDEVYVALEHVEGWTGRITLPSEDIEFGSQVKRFHVGDVLFGKLRPYLAKVTRPSVKGVCVGEFLVLRRKNEALLPEFLEQELRSKLFIDIINSATFGAKMPRADWDFIGNLLIVYPPTHAEQLEILSDTGKQTASLQAAIDKANREVSLIQEYRTRLIADVVTGKVDVRNVKCEGRSVNEEEFEDIEEVEKAVDLLEESEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP84</accession>
    <name>D6SP84_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869880.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1932"/>
    <dbReference type="EnsemblBacteria" id="EFI34560">
        <property type="protein sequence ID" value="EFI34560"/>
        <property type="gene ID" value="Dthio_PD1932"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2033912at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027588">
        <property type="entry name" value="XXXCH_dom_fam"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04358">
        <property type="entry name" value="XXXCH_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10614" checksum="6CE8A60B436313FA" modified="2010-08-10" version="1">MKTATLNTRIEAFIQDILNSQNDNQMPSLNEVQEFVRAARALPMKADESWLAEAEDFSHLADQLLLAVKNSQFEEAVQLMDSIREAWTFIAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPC4</accession>
    <name>D6SPC4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gamma-glutamylcyclotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869920.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1972"/>
    <dbReference type="EnsemblBacteria" id="EFI34600">
        <property type="protein sequence ID" value="EFI34600"/>
        <property type="gene ID" value="Dthio_PD1972"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1984556at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="PTHR12510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="3">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="118" mass="13818" checksum="07399CF6E6B9A785" modified="2010-08-10" version="1">MEYVFVYGTLRKGCSNHHLLKDARDIGPARTSEDYALYVHDYPYTVKSEAVGPIRGEVYLVDGRGLDRLDRLENHPHWYVREKKPVQLDEGREVQAWIYFFPEPRGHLVKSGDFVYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPE6</accession>
    <name>D6SPE6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NMT1/THI5 like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869942.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1994"/>
    <dbReference type="EnsemblBacteria" id="EFI34622">
        <property type="protein sequence ID" value="EFI34622"/>
        <property type="gene ID" value="Dthio_PD1994"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="317" mass="35387" checksum="E414DA5FCF518E92" modified="2010-08-10" version="1">MNKYLFSAFVFLLLSLFTGVQGLHAETWRIGTWKTAQTIQPFFYEDFSGSARVQVFPFTNPADQRSALLAGSLDMTGTTLVHAIAAASRGEPVVLVAALCNKSSALVVHKNSQVQDVADLKEMSIGYVPGTMHEVLLRETLEQHGVDPERDVNLRRVDFFDMGTALARGDIDAFLSGEPFPSLAVHQGYGRILTYPYFDDSIGHINAGLLVTSKTVKERPELVQSMVNAHMQATEHLTRHKDQWLQAAGDFGTPIEVLQTAADNMELAWDMDETFVRRVQKLGARMQELGMIDEQPDYEKLLNTTFVENARRQNGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPJ9</accession>
    <name>D6SPJ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2047"/>
    <dbReference type="EnsemblBacteria" id="EFI34675">
        <property type="protein sequence ID" value="EFI34675"/>
        <property type="gene ID" value="Dthio_PD2047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="PTHR31303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="215" mass="23272" checksum="D4225E0E4BDC6C7B" modified="2010-08-10" version="1">MPDPQKHDMHGRHDSGFLPLRRELMRKSLHVLALVIPAAMLLLGKPPSIVIFGGLAFLGIVLDIIRAGKAPLNYWIVNFFGSLMRPREKELPQGRVVVNGATWAMLSAFLLVLFFPVQVAAFAFTIFMLGDAAAALAGRRMGRIRLGKSPKTLEGSLAFLATALLISLVFPGIYFWHGAASSLAACIAEAAPLPLDDNLRVPLVAALTMLAVQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPK6</accession>
    <name>D6SPK6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ORF">Dthio_PD2054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870002.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2054"/>
    <dbReference type="EnsemblBacteria" id="EFI34682">
        <property type="protein sequence ID" value="EFI34682"/>
        <property type="gene ID" value="Dthio_PD2054"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="522981at2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="188"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <begin position="154"/>
            <end position="156"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="4 5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="420" mass="46067" checksum="E7BADF6C53C97D26" modified="2010-08-10" version="1">MDKGNHYEVKDMSLASQGHKNLELAELNMGALLKVRERFAKEKPLKDIRIGLALHVTKETAILVRTLIAGGADVAITGCNPLSTQDDVAAALADEGVKVWAYKGETKEDYYRYINKIIEFKPHITIDDGCDLVSEIHKNHAHLIPDIICGCEETTTGIIRLKAMEKDNALKYPMIAVNDNMTKHLVDNYYGTGQSTVDGILRATNVLLAGKNFVVAGYGSCGKGVAKRAQAMGANVIVTEVDQFCALQAAYDGYKVMRMEDAAKIGDIYCTVTGNKHVIRMEHVKNMKNGSILCNSGHFDNEIDIPALEKGAESKREVRTSMDEYIVGGKKIFVLGEGRLVNLAAAEGHPSEVMSTSFCGQALACEYGVQNRGKMENKVLQLPVELDDDISGLQLTAMGIEIDELTQEQKDYLDSWEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPL9</accession>
    <name>D6SPL9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870015.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2067"/>
    <dbReference type="EnsemblBacteria" id="EFI34695">
        <property type="protein sequence ID" value="EFI34695"/>
        <property type="gene ID" value="Dthio_PD2067"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004010">
        <property type="entry name" value="Double_Cache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08269">
        <property type="entry name" value="dCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="343"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="669" mass="75385" checksum="93C3818CBEB74B7A" modified="2010-08-10" version="1">MFKTMRSRLVAIIALILLLTAAVIIYFTHRDVGREVTRLEQNNAENILNSVFLNIQGVYRGLIFDRVSSIDRAKDRLHREVRMILSGLDLPEAPVETPAREFEKSGKDELLEWLQALGQGDTEFFVADPGQDIIFSSREGLKGRNLDQMQDLRGEPISDAVNREESPRRQYIVFSPESKETEKDQNLAYLSSFPGLEWVLGAFVDISSIEEAEKDRMQELIQELQDQFRQVSLAESGSLFIFREDGEMVVPPHEPAHEEELAPHLPGLARQSLQSETGRSTLDTGQGYMIVLTRYFRPLDWYLSAMIPEAEIRAPAQGMVQRQSWLIAGIFLLGALAAVFFVRHISRPLSLLAGHTRDLAGKDLASDDFESEKIIALTRKHHDEVGELAGSFVYMQEELKKNVRKLLETTAAKERYESELSLARDIQMSIVPRKFPAFPDIREFDLFAILEPAREVGGDLYDFFLLDEQHLCFTVGDVSDKGMPAALYMAITRTLIQSHAAKEKSPAGIMARVNNDLSRDNPKSMFVTLIIGILDMSTGEIRYANAGHNLPIHMDAQGGLSFVKGISGPVAGAMEDLPYRELLVTLNPGESLFLYTDGVTEAMNQKQELFSDERLLQTAMQAKNQELQKLLHDIRKEIRTFSADVPQSDDITMFVLRYYGPGASLKPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPM1</accession>
    <name>D6SPM1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870017.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2069"/>
    <dbReference type="EnsemblBacteria" id="EFI34697">
        <property type="protein sequence ID" value="EFI34697"/>
        <property type="gene ID" value="Dthio_PD2069"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1155949at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="342"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="737" mass="81422" checksum="F96D4AAB7C222EEC" modified="2010-08-10" version="1">MKPDLSLKVNVFLVAVAVIILGQAAYSYFNINAFQSSHVSTIREKAQSAGQNLKNDLEYVLDMGISLERIARLEDNLENILADLPEVEFMEITDTRDYTLFFADHDQALDIEPGTRKSDFVHKPYVSELSRKGLTPEDTDISLPLKAQGQLQGQINMHISGSVIHAQSRQIMWDMLTVMFTSLLLTFEFLTFFVIYYISHPLSVLRRDISRSYPRLMSVDSDKYASLGEISVLADYYNSIIKNQAQRFATGLRGFLPDLSQGLSAPPRQQTEKISGLVQELDGPESSRAQAPQAALQKIRACLQKVNTYWSDLAISMEGGSRTRAPAADRDEASGSVPYSLIRPLIFLFIMADGFSLSFFPMYVDSLYEPIMGLSREMIIGLPIAAFMLTMAVSMPLAGSMTDSRGWFRPLIIGLLLNAAGHFLTAMAQDILWLIVFRCLAAVGLGMVFMCCQRFVIDNTSLKSRSMGMAGFLAAFFSGDICGTVIGAMLAERIGYANVFYVSALFTCLALIFAVLVFRGEFRPAKPQSSGGFGLPFKASQLFQVFRDREFAAVLWLQAIPAKLVLVGFLFFFVPLYLSSIDALQSNIGRVIMCYGICLVFAGPLISHLFPQVYLRKYFILLGGLITAGAMLSFALFSGFIPILVMVIMLGIAHSFSVSSQASVISETDIVKKLGPGAGMGIYRFWERAGNVAGPLVMGFLIARVGYESSVVLFGILTLISSILYLGFLIRRNWLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPN7</accession>
    <name>D6SPN7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34713">
        <property type="protein sequence ID" value="EFI34713"/>
        <property type="gene ID" value="Dthio_PD2086"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50336XT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="571" mass="64878" checksum="D2E1DAB6C0745614" modified="2010-08-10" version="1">MINMGPGSENLEKTSRGYQYSTPGFLNPLTGEKKTERDPSRPNLFSVLGRSPRSSATGHRSFAEEAKGDTYRTDGFAGRVWGIGWDDNVTKVMNIILQLTLERRPPEIVNLVGWSRGAVTCLRIANRIFDDLKYQVKINILAVDPVPGGTTEVTYDMKMIPPNVQYYLAIIALDDDRKNFQPIDRTEIICPEPGAVINLKKYRGGEDKHKIHNPPSNPPLPPSIHFLPFPGNHSTVVGAFKKLSEVDPGSLAVSDMVRHISKNFLSYHGTVFSQSYMDDPIQNVEDILHYYKIINSSKELIRERSASSFYGGKIVGGGYQERKVRKMNRILHTSMPDLFLNDHEHYCYDILKKFGRYKSCRSQNDFDIDVKNSSYVILKEKMPGWSDKYVKKYFDIPPQAHPQSMGLVNQASDTQSVKSYGVNIKNGQHWVKRVGGTGTYVSLKNLNTIKMFIQGNSSNTETLLPEKYTKDSKIISQDEWVKFSRSGFFAKRKRIIHVDEALNVYRNSFEYMDSVSSKEKSLHLRQTVQKAFNVVSACNYYLAHGGDREVAVKCLLWVVVKDVEFIRSILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPN8</accession>
    <name>D6SPN8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870032.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2087"/>
    <dbReference type="EnsemblBacteria" id="EFI34714">
        <property type="protein sequence ID" value="EFI34714"/>
        <property type="gene ID" value="Dthio_PD2087"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="469277at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="83"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="584" mass="64740" checksum="61A2B26277ABBC70" modified="2010-08-10" version="1">MLEDQNPLDLAAIENSLCCPGIQGPDNIAWLESSWENPGSFWHGLVQAHQRQVPGRVKSELFRHYDFFYDLAGRFKDRPLQAMQVLDSKGRAQSLSYAELGRQAALLSRAWAGAGAKNGQLVALVLHPGPELAAALLAALKLGLVFSFVPPQGRWLVQRRLKALDPDHLVMDSLHAAQLRAYASRVLPWTVSSSSSDNYPETISSVYPSGSTAALLFDPSSMEPDMPRAVSSDTLYLGAMRDGLIALGLRPGEFFAAPGFNPLTTWPSMLLASLLNAGTIVHMTLEQIREDPRRILSVPCKVLGISRGLRDILLKEPLSLRKSCEHWFRHPGETVDITPWMDWIEAMDLKKSYASNLAWTPVLGGCCLISPRRMGIAHNHVLPAPGSLWHLRDITDPSTPSMGDWGVLVQSIARNLAGHDETQLETTLPAPAVIAPQGQVWNYIRPPHVDQDGLHFPENMVQEVAASALPRGVLCLLITLPGYAARDDSRRVLVVFTAACIRNDGTMNPGQAQIRDHLRRTISRELGAYYLPHKIEFLPLFPRMIQAGEMDQEWSRDQYLSGKLHKKAKNQLFRQIGRFQAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPR2</accession>
    <name>D6SPR2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870056.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34738">
        <property type="protein sequence ID" value="EFI34738"/>
        <property type="gene ID" value="Dthio_PD2111"/>
    </dbReference>
    <dbReference type="OrthoDB" id="600082at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088143" evidence="1">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="9980" checksum="6CD9B2EB5DE10626" modified="2010-08-10" version="1">MKKFIVAPLCMAILSGFLVFGLQGKSLQADDGQVIMENRCTTCHGAGRIERAGHDMDGWKDTVSRMEGKGNFGEPLSDAERQSLLKHLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ03</accession>
    <name>D6SQ03_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870143.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2219"/>
    <dbReference type="EnsemblBacteria" id="EFI34829">
        <property type="protein sequence ID" value="EFI34829"/>
        <property type="gene ID" value="Dthio_PD2219"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="340" mass="38855" checksum="255D2780BC5464C3" modified="2010-08-10" version="1">MTLTYLKFHRFTAFDRLELDLSPGINVFIGTNGTGKTHLMKAAYAACDITKSKLGLADKLVRVFLPSNRHIGRMVKRQKGSSRAKLDIRRGNKKLTLSFSNHAKLSRSATSTGEKDWVKDPVESVYIPVKEMLANAVGFRSLYAQREIHFEEIYADILDRAYRPPLRGPAEKSRKSLMNSLQKIIDGLVIVKEEEFFLRNKEGNLEFSLLAEGMRKLGLLWLLIQNGTLLKGSVLFWDEPESNLNPKLFGTMMEILLALQRQGVQVFLATHDYVILKELDLRRRKRDKVVFHSLYRDEETNEIALQVALNYQQVHPNAIADAFSDIYDREVERSLGAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ38</accession>
    <name>D6SQ38_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Calponin (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870178.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2255"/>
    <dbReference type="EnsemblBacteria" id="EFI34864">
        <property type="protein sequence ID" value="EFI34864"/>
        <property type="gene ID" value="Dthio_PD2255"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50344VJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2054700at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9855" checksum="2D877B202FC3F016" modified="2010-08-10" version="1">MLIQTKIQIEPEHYEFIKKVYKELNYKSLSEYMRQAVKTQVREDRKRLRALKRQQAMEMIGQGPYPNQFEDIEGEDFERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ45</accession>
    <name>D6SQ45_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family UPF0547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870185.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34871">
        <property type="protein sequence ID" value="EFI34871"/>
        <property type="gene ID" value="Dthio_PD2262"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50313Y7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1972420at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="15697" checksum="1F02576883EA0331" modified="2010-08-10" version="1">MDFFATWLLVGLISAIIAARKGHSGCGWFGLGILLGPFGLIMALLAPKNPENVRKIASAGHKWKKCPYCAEKIRAEARKCRYCGEAFGSGEGEKIVSAAYAGTGLEKVLEEIRYRLLDTNLGAFIVYFIIAAIIVFYIFGSGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ70</accession>
    <name>D6SQ70_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870210.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2287"/>
    <dbReference type="EnsemblBacteria" id="EFI34896">
        <property type="protein sequence ID" value="EFI34896"/>
        <property type="gene ID" value="Dthio_PD2287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1640364at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="228" mass="26173" checksum="66A1A683FC3C73E6" modified="2010-08-10" version="1">MQQKSQQHGYRELKKKVPLLLENRDIDQVLPELMQYPAQKLLGALYAALLSPRKLIKWHSVTAIGVTVSRLAQNDPEQARIVMRRFMWTLNDESGGIGWGSPECMGEIMARHQGLAREYRRILFSYLVQGDTGSDNYLEYLPLRRGAFWGLARLAQGDPVLSREATYQVQKALKQESDPEILGLICLYLRLSRRSKDEFPRPDPGSGTLEIYWDQQLQSIPARELCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQK3</accession>
    <name>D6SQK3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2062 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2423"/>
    <dbReference type="EnsemblBacteria" id="EFI35029">
        <property type="protein sequence ID" value="EFI35029"/>
        <property type="gene ID" value="Dthio_PD2423"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1672574at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="2">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="159" mass="18301" checksum="581A20B43A1E0012" modified="2010-08-10" version="1">MYSLKRFFRFWYLKLLRIRESPHNVAMGLSLGVLVGCLPIIPLQTVAAVILAFFFKCSKIAAAIGTWITNPLYAPFVFYGMYLLGRAVIPVGKKEFEPEDLTLLNIVNLGWDFFLLMLAGGVIVGLTLAFLTYLVSVRMVYLYRQKRSLRMQLKRLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQT2</accession>
    <name>D6SQT2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="4">3.1.1.61</ecNumber>
            <ecNumber evidence="4">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cheB</name>
        <name evidence="9" type="ORF">Dthio_PD2502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CheB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="4"/>
    <dbReference type="EC" id="3.5.1.44" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2502"/>
    <dbReference type="EnsemblBacteria" id="EFI35108">
        <property type="protein sequence ID" value="EFI35108"/>
        <property type="gene ID" value="Dthio_PD2502"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="8">
        <location>
            <begin position="188"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4 6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="383" mass="41263" checksum="17F6D160A4AC74A6" modified="2010-08-10" version="1">MPDDQCPVRIFFPEPCGPDNRVQRETKVAKVIRVVVVDDSAFMRKAISTMLQKDPEIEVAGVARNGQEGLDMVRKLNPDVVTLDIEMPVMDGLTALKHIMMEMPRPVIMVSSLTTEGGEATLKAMEYGAVDFIPKQLSKVSLDIVKIEKTLQSKVKTVVQKKGSQAGAVARSKPRTAKEVSRTIQDRPRGKVVRDIVVIGVSTGGPPAVQKVLCELPPDFPAGILIAQHMPGAFTGPFAKRLNDASSLWVKEAEDGDVLSPGRVFIAPGGRHLILNPRASRIELSVTAKPEDVIYKPSVNVLFSSAASGPGHRTVGVVMTGMGSDGLLGARDLKAKKGVLLAQSEETCVVYGMPRAVIEEGLADQVLSLDDMAQAITNHLYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQV6</accession>
    <name>D6SQV6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870446.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2526"/>
    <dbReference type="EnsemblBacteria" id="EFI35132">
        <property type="protein sequence ID" value="EFI35132"/>
        <property type="gene ID" value="Dthio_PD2526"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088272" evidence="3">
        <location>
            <begin position="37"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="30"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="171" mass="19368" checksum="6CEF15DB6757250B" modified="2010-08-10" version="1">MHKKYCRGTFQNLHAAALSACICLALLLALPLAATADDSSVPEEVDPEEIEKLVEDEKGKVLILNFWATWCAPCRAEIRDLVRIRQDYSPDRVSIIGISLDFNPRAVPDFMERKNMNYPVYISSQDVMDAYDITGIPYTLIYDAEGNLAEVHESLVDYEILQEELDRLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR17</accession>
    <name>D6SR17_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0003</name>
        <name evidence="3" type="ORF">Dthio_PD0084</name>
        <name evidence="4" type="ORF">Dthio_PD0092</name>
        <name evidence="5" type="ORF">Dthio_PD0451</name>
        <name evidence="6" type="ORF">Dthio_PD0483</name>
        <name evidence="7" type="ORF">Dthio_PD0749</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870505.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0003"/>
    <dbReference type="EnsemblBacteria" id="EFI32721">
        <property type="protein sequence ID" value="EFI32721"/>
        <property type="gene ID" value="Dthio_PD0003"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32787">
        <property type="protein sequence ID" value="EFI32787"/>
        <property type="gene ID" value="Dthio_PD0084"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32794">
        <property type="protein sequence ID" value="EFI32794"/>
        <property type="gene ID" value="Dthio_PD0092"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33133">
        <property type="protein sequence ID" value="EFI33133"/>
        <property type="gene ID" value="Dthio_PD0451"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33160">
        <property type="protein sequence ID" value="EFI33160"/>
        <property type="gene ID" value="Dthio_PD0483"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33417">
        <property type="protein sequence ID" value="EFI33417"/>
        <property type="gene ID" value="Dthio_PD0749"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032T9N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1455603at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="12379" checksum="B2B79A333C964561" modified="2010-08-10" version="1">MQVDQAYRLNKRASDQRWSARNPDYWNNYRENNPDYTRSNREKQRYRNRRRRAIESISSEIAKLDALSAENSDISGTYAMISVQDLLIAKMDAKIVKITEVSMGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRA8</accession>
    <name>D6SRA8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ruvB</name>
        <name evidence="8" type="ORF">Dthio_PD0550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870582.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0550"/>
    <dbReference type="EnsemblBacteria" id="EFI33224">
        <property type="protein sequence ID" value="EFI33224"/>
        <property type="gene ID" value="Dthio_PD0550"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="874197at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="41"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="319" mass="35267" checksum="F635854EAA30BB08" modified="2010-08-10" version="1">MNSSTNDEHVRPHTLDQFVGQEDVRSNLKVYLGAALERGLHLDHTLLYGNPGLGKTTMARILAGELGVNIVCTTGPVLERSADLAAILTNLSRNDVLFIDEIHRMPATVEEILYPALEDFKLDLILGQGPGARTVKIDLEPFTLVGATTRIGLLTSPLRDRFGVICRLDFYAPEELATIVERSARILGINITSDGALEIGRRSRGTPRIANRLLRRVHDFAVVGRQEVIDSQVASRALKRMDVDPLGLDQMDRKILDCIIRQFAGGPVGVKTVAVACSEEVRTLEDIYEPYLIQCGFLKRTPRGRVATPRAYEHLNLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRC8</accession>
    <name>D6SRC8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870602.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0570"/>
    <dbReference type="EnsemblBacteria" id="EFI33244">
        <property type="protein sequence ID" value="EFI33244"/>
        <property type="gene ID" value="Dthio_PD0570"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="142"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="410" mass="44891" checksum="EE7609B03EEC0552" modified="2010-08-10" version="1">MVDVTELNPGQVLESSVVTPNGRLLLPGGMTLTREHIAFLHKWGIARVHVQNQEGEPAALDQDLINAIESYLTPFYACNDIEEPVTRAVYEHAVKRLALKCQQGWTIPRKEPNLPVNDGNLLDSFYAGEFSLKDLVNHDVELSSFPDIYFKIHRAINSPHSTAEYLAGIISKDPSLSAKLLRIVNSPFYGLTSRVDSITRAVALVGVNELSTLALGISAISAFKDIPGELVDMRSFWTHSVAVGVLSRHLGRDFPEISGERLFVAGLLHDIGRLVMFRRLPAISTEAIIYAQSNLLPLVEAERDFLGFDHGLIGAALVKSWKLPQYLAHPLGGHHREDCLGSPMTAMVHLADFLAIAMAFSQKGSLIAPPLSPSACKTAGLTPEKLENIISGAEEEFENIVDIFFAKGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRI6</accession>
    <name>D6SRI6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870660.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0628"/>
    <dbReference type="EnsemblBacteria" id="EFI33302">
        <property type="protein sequence ID" value="EFI33302"/>
        <property type="gene ID" value="Dthio_PD0628"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50346K2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1829959at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="338" mass="39056" checksum="14CE29E474B5E960" modified="2010-08-10" version="1">MGKKVLISAVLAIVILGAGALVWYYQFREPPVEPDDPDITMHPVEKPDDPVDVTGLDPLREHLEREPEDPVEPREPEELPDDEVITDRFIRDLASLIFRNYHPAVSPAEEGGFTLSFRELNMHYATELTGLSYEEQDVLQAREEVLGHLLQPEVIDLVVRRYGPELFDRLVHLAETEPREVHTSQGLQERQLENRETVEMLEIVAQRLEHLAHVFSRTSSEEPVLERMRDYLDTVEELNSVYFEYWQLDESDDERRSELASRIKQLIMQRENIRGKIVDRVSTPQIAEAGLDVLYQVQWIFRRVEKGGFSRDSIQAMAEAGEDLASMARDRADELVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRJ7</accession>
    <name>D6SRJ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin B12-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870671.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0640"/>
    <dbReference type="EnsemblBacteria" id="EFI33313">
        <property type="protein sequence ID" value="EFI33313"/>
        <property type="gene ID" value="Dthio_PD0640"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="89"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="212" mass="22741" checksum="2D8D61CA4BBA157A" modified="2010-08-10" version="1">MSEKLGKIADGLLHGKIDEVGELTQELINDGMDPEEILQKGLFAGMDIVGKKFRDCEMFIPEVLRSAKAMHAAMEKLRPVLSEESSSKAGTVIMVTVQGDLHDIGKNLAGMMMEGAGFNVIDMGIDRKTEDIVEMVKKEKPQILGLSALLTTTMPKMGEVINALKEAGIRDQVKVIVGGAPVTDDFAQEIGADAYAPNASIGTEKALELVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRM9</accession>
    <name>D6SRM9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870703.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0673"/>
    <dbReference type="EnsemblBacteria" id="EFI33345">
        <property type="protein sequence ID" value="EFI33345"/>
        <property type="gene ID" value="Dthio_PD0673"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="16490" checksum="2D039C3875E00C09" modified="2010-08-10" version="1">MSIEKPCPSCGHPVAVFRNPVPTVDIIIHFPPRGIVLIERKNPPHGWALPGGFVDYGETVESAAVREALEETGLQVTLTDLTGVYSHPRRDPRQHTMSVVFVAHPLAGQELSPGDDAGRAGIFDLDNLPELAFDHKEILADFTCKLDRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRS6</accession>
    <name>D6SRS6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0723"/>
    <dbReference type="EnsemblBacteria" id="EFI33392">
        <property type="protein sequence ID" value="EFI33392"/>
        <property type="gene ID" value="Dthio_PD0723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10301" checksum="CF9987737C8129B0" modified="2010-08-10" version="1">MEKEVAEMRMKVQYILSVPVGFHNTVPVGFHNTKSKDIYKINAAEILDNLQKAVLFDIAQRQARQGCSSVSLLRLAQFSRTSSMFSICCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRY1</accession>
    <name>D6SRY1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="10" type="ORF">Dthio_PD0781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870799.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0781"/>
    <dbReference type="EnsemblBacteria" id="EFI33447">
        <property type="protein sequence ID" value="EFI33447"/>
        <property type="gene ID" value="Dthio_PD0781"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="551" mass="58467" checksum="159119D73024BD25" modified="2010-08-10" version="1">MSAKQVLFDVKAREKLQKGMDQLARAVKVTLGPKGRNVVIEKSFGAPTITKDGVTVAKEIELEDKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQAIFNEGIKLVAAGRNPMAIKRGVEKAVESVVKELENITKPTRDQKEIAQVGTISANSDPTIGNIIAEAMNKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYLSPYFVTDAEKMVSEMDDPMILICEKKISAMKDLLPVLEQVAKMSKPLVIIAEDIEGEALATLVVNKLRGTLQVTAVKAPGFGERRKAMLQDIAILTGGQVISEDVGFKLENATVNELGSAKRVVIDKENTTIVDGAGKAEDIKARVKQLRAEIDETTSDYDREKLQERLAKIVGGVAVINVGAATETEMKEKKARVEDALNATRAAVEEGIVPGGGVAYIRALPSLDSVKADDDDETSGVDIVRKAMVEPLRQICINAGFEGALIIEKVKDSKDGNGFNAATGQYEDLIAAGVIDPKKVTRIALQNASSVASLLMTTEAAIADKPEDKKEGGGAPAGMGGMGGMGGMGGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS05</accession>
    <name>D6SS05_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870823.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0805"/>
    <dbReference type="EnsemblBacteria" id="EFI33471">
        <property type="protein sequence ID" value="EFI33471"/>
        <property type="gene ID" value="Dthio_PD0805"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="769"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="800" mass="86647" checksum="E9ED861FCCDB2FB1" modified="2010-08-10" version="1">MSIQNLVSRLFEFLAHRKLLLLLALAACLSFAFITLKNLSVSEDISTMLPDDSSRTAEDFRKLSSAQLLSRIFVILEDQDGKAPDSLVQAGVNIRSEAGAPWFEPMPSSSDKMAPSEAMQHLMHLMPATVSVQDLDRMEKKVEPDAVRQSLEQAREDLAGLQGIGLKKVIRMDPLKLRTIVLEKLGFLDMFGNDAGAVLESSGVYQSADRKSVLVSLESPVDMTDARGSREMLRQLEEIISKQLPDHARAHIISGHSYTVANADTIQKDLVVVLAVSALGILILYLGFVRTWRGLMVYAIPFASLLAGIAAVAVTSSAVSGITIGFGAVLMGLSVDYGLHVYYAVQSGPTAVKALTRVCRPILFCWLTTCGVFSMLFLSSLPGQRQLALFTISGLSAAMLLALMVLPVFLSASGSVPQRKLFAAFRRQSYVGKWTAVTVFLGLVLSAALCWPGISFDGRLQALNKVPEELAEAEQAVTESWGDVRGMAMIFSEGDDLDMSLKNADNLFRHLSAELPGEAIISLAPLLPPESRQQEAMEGWQKFWSEHQTKLKEIIDRESRDLGFSAEAFDPFFDFIAAVPQPVTQKELHVLGLGDAMDMLVYTEENSSRVVTMVPDNPEVHALFASGVDSGVQPFQDARLVSQELLSQDIAADLRKDITGFLVAAGVFVLALAALLFRDLRRVFQALLPAVAGLSSLIIGAALLGLEFNLFSIAAMFLVLGLGVDYGIFMTLRITCRENAVTERAVLVSGLTTLAGFGALTLADHPALYSIGVTILTGIGPAMLAAIILVPALEKKHHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS12</accession>
    <name>D6SS12_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870830.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0812"/>
    <dbReference type="EnsemblBacteria" id="EFI33478">
        <property type="protein sequence ID" value="EFI33478"/>
        <property type="gene ID" value="Dthio_PD0812"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="409" mass="43493" checksum="7F5F5B22D5F4705D" modified="2010-08-10" version="1">MSLNRVVVTGMGAVSPYGMGADILYSSLKKGASAIRQVPDLETVKGLRCHIAGVVPDLDEKQIPRKFRRSMSRMSVYSTLAAMEALEMADVREEQRRSEQTGVIIGTTVSSPQTLQDFFSDYLQDFSVERVKSSLFFKIMGHSCAANVAQSLGITGRILAPSAACATGVQAIGLAFEAIALGRQDIVLCGGAEELHPLTVAIFDIINAASTQFNTVPDSSPRPFDERRDGIVCSEGCGILVLESLDSALSRGASILAEIVGFASNTDTSNISTPDSARIEQCMRMALASAGVGSDEVDYVNAHATATTLGDSAECRAIEHIFGADIPVSSFKGHFGHSLAASGSLEMIGMLNMLQEEVCLPTLNLNIPSEDCAMVRHVQTLESCAVKTALKNNFALGGVNTSLVVRKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS41</accession>
    <name>D6SS41_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ORF">Dthio_PD0841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870859.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0841"/>
    <dbReference type="EnsemblBacteria" id="EFI33507">
        <property type="protein sequence ID" value="EFI33507"/>
        <property type="gene ID" value="Dthio_PD0841"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="129" mass="14733" checksum="D53C330B966252EE" modified="2010-08-10" version="1">MTQSRKKSPSPMEQKLHHLAGALHEKKATDLYALDVTVYCSAFEGLILATAQSERHARSLADHLLEVAHGQNWDYLGMEGYQQAGWILLDFNDILVHIFQEEHRSFYNLEGFWNRGLSIALDLPENDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSC5</accession>
    <name>D6SSC5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870941.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0926"/>
    <dbReference type="EnsemblBacteria" id="EFI33591">
        <property type="protein sequence ID" value="EFI33591"/>
        <property type="gene ID" value="Dthio_PD0926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="59" mass="6928" checksum="242840EAB32805CA" modified="2010-08-10" version="1">MEAIEKLAEKVDRLLELKNRLEQENQSLRQELEAEKQKNNTVAAKVDELLQKIEDETSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSG3</accession>
    <name>D6SSG3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870979.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0964"/>
    <dbReference type="EnsemblBacteria" id="EFI33629">
        <property type="protein sequence ID" value="EFI33629"/>
        <property type="gene ID" value="Dthio_PD0964"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018818">
        <property type="term" value="F:acetylene hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02781">
        <property type="entry name" value="MopB_CT_Acetylene-hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037949">
        <property type="entry name" value="MopB_CT_Acetylene-hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088185" evidence="7">
        <location>
            <begin position="29"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="762" mass="86401" checksum="82811B8F9044D9FD" modified="2010-08-10" version="1">MAITRRRFLHYSALVTSSLAVSGLPLYAYDPNAGPEEHDEVRRSYCGLCHPRCGTLLHMKNGKVFEVSGDPDHPVTRGLICERGLLMPEHIHHPDRINYPLKRKGKRGEGKWERISWEQALDEVAEKLAGLRDEYGPETLAFTHGTSRTHHWDCRRFFNLFGSPNVCGVNNICMCPSYATEYATYGGMARGNPRQAQCIVVWGRAAANSSPVQTWPALKDARDKGVKFIVVDPRRIQEVEFADMWLQIRPGTDLAMMLGWIRLIIEEELYDPEFVSNWTVGFDELKEAVKEYTPEKVSEITWVPAEKIKAAARLYAESSPAQIPYGYGLDKQGINSNQCARARAILRAITGNLEIEGGETFSQTPEAAKVRGEFDLVRAEAISSEQRAKQLGVDTYPFFGFPGWERNLENNKKLPQGMVSPPSMYRTCVAHARDVFHAVSTGEPYPVKAMFSVASNPMLSFPDSKMVFEALKALDLYVVMEYYMTPSAALADYVFPSATTVEQPQLWTTGGFCMSCPPGIEPMYERKDTYHFYRGLGVRLGQEEDWPWENLEEVFDYCLEPVGLTFEELSRDYGFRGTPEFKRYEKHGFGTPSGKVELYSSIFEELGNDPLPRYKEPPWSPEGDSRVAGDFPLILITGSRFMPMYHSEQRQIEPAREQMPDPLVLVNPETAEELGLENGQWVKVISPQGETRVKLEKSAVMHPRMVDVQHGWWFPEREEARPELFGVFESNANTLCPMDEKFCSPEIGSWPHSALMCRIEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSI5</accession>
    <name>D6SSI5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871000.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0987"/>
    <dbReference type="EnsemblBacteria" id="EFI33651">
        <property type="protein sequence ID" value="EFI33651"/>
        <property type="gene ID" value="Dthio_PD0987"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="16446" checksum="21F0D798C6DA81AD" modified="2010-08-10" version="1">MKKSIVCIGSIWITEDMAGLQVYKRLQDTEHPRTVEVFFGGLSGLNLLPFLEQGGRVVFVDNVKGFAAPGRVVVLDQSQVIASRELRHYGHGAGLPFLLTVLPEVCTGTMPREIFLVGIEEKFTSESVQEAACLSLQIAENGRCCHGKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSK8</accession>
    <name>D6SSK8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nitrate reductase gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871023.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1010"/>
    <dbReference type="EnsemblBacteria" id="EFI33674">
        <property type="protein sequence ID" value="EFI33674"/>
        <property type="gene ID" value="Dthio_PD1010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1262541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="9">
        <location>
            <begin position="124"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="357" mass="40665" checksum="81C66EAC31109894" modified="2010-08-10" version="1">MKAIYSLILVVALILIAMVGAGALGMGALFGVIIPYLAVLVFIVGFVVRVVQWGKTPVPFRIPTTCGQARKSLPMFKDKWNRLDNPGTKLGVVGRMFFEVFLFRSLFRNTRVELHQGPHIAYSSSKWLWIFALIFHYTFLLIFLRHMRFFTEPVPELFVTMDHMDSMFQILSPALYLSSALILVALGYLLLRRLLVPSVRYISQPADYFPLFLILGIVISGMLMRYIGPFKTDLMAVKELTMGLVQFSPTVPEGIGATFFVHLFLVSVLLVYFPFSKLMHLGGVFLSPTRNLPNDSREKHHENPWNYPVKFHTYQAYEDENREVMVEAGLPVEKPLEEKTEEASGEETSDDNAEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSV6</accession>
    <name>D6SSV6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871121.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1111"/>
    <dbReference type="EnsemblBacteria" id="EFI33772">
        <property type="protein sequence ID" value="EFI33772"/>
        <property type="gene ID" value="Dthio_PD1111"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="329"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="433" mass="48200" checksum="6CDC37B8960D4F05" modified="2010-08-10" version="1">MKDTLVHKLDSGEARIGIIGLGYVGLPLALRYLAVGYSVLGLDIDPHKVNRLMKGESFIRHIPSEPLQEGVQQGRFQATTDFSRAGEADALILCVPTPLDRHREPDLSFVVNSLEEVLPAMRPGQVVSLESTTYPGTTDEELRPRIEAAGFKTGRDVFLVYSPEREDPGNPAFNTRSIPKVCGGVTPECLEVAMALYGRVIDQLVPVSSTRAAEAVKLMENIFRSVNIALVNEMKTAFMKMDIDIFEVIRAASTKPFGYMPFYPGPGLGGHCIPIDPFYLTWKAREYDVATRFIELAGEVNTSMPYYVVQRAMEVLNDFGRALKQARILLLGLAYKPDVDDDRESPTYKIMHLLEQKGADVSYNDPYVPVIKPSREYAHYAGRRSEQVSGEYDLVILCTAHKEYQNLDPADLGVPVLDTRGFFADLTGRVFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST84</accession>
    <name>D6ST84_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871249.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1239"/>
    <dbReference type="EnsemblBacteria" id="EFI33900">
        <property type="protein sequence ID" value="EFI33900"/>
        <property type="gene ID" value="Dthio_PD1239"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="470487at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088295" evidence="4">
        <location>
            <begin position="25"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Omp85" evidence="5">
        <location>
            <begin position="305"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="595" mass="67263" checksum="FE307AA2AE119118" modified="2010-08-10" version="1">MTTKISILFFLALLLYGLQGYASADQQEQDPAATSYETEFRGDIDSRMRQILNQVSDTVALKERPLVSVSQLKRRVRDDIPEFVGALRSFGYYAPDITYTIHEDETPVRVVFEVNQGPEFLIEDVEIIPKDSDWEGEVPDPEVLGLYKGERIRSSTVKESTRKLDSYLKARGHPFPRTRVQEVVIDHADNSAIVYLAFDPGPRAGFGDMEIVGLERVQEEVVLERVPWETGDEFRAPQMEGLRRDLMATGLFSVVEVNHGYELDEEDLLPMQVRVRERSPRTFRAGIGYQSDIGPELRLGWVHRNLRGKGETLEADLQLSDVERFLGGSYTIPSFMRPDQRLILKSGYREEYQDAYDATSISATGTVDRDLTRELSVGAGAGYRLAQVEQMGEKTDLGLLFFPGNLLYDARDNELDPSQGLRFNLRLTPFLDTMDLETRFLKTYASLSNYLELWPQRIVLANRVAYGAIGAEDKRKVPPDERFYAGGGGSIRGYAYQKVGPMEDGDPIGGLALAEVNTELRFKLSRNSGLVMFLDGGQAYEDSYPDFSENLRWGTGIGYRYYTDFGPLRADIAFPLNRRSKDSAYQLYLSIGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST88</accession>
    <name>D6ST88_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar motor switch protein FliN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871253.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1243"/>
    <dbReference type="EnsemblBacteria" id="EFI33904">
        <property type="protein sequence ID" value="EFI33904"/>
        <property type="gene ID" value="Dthio_PD1243"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875967at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="9">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="187" mass="20871" checksum="0103AC7E1D6BFCF9" modified="2010-08-10" version="1">MSPNNKEENDQDKLAEEWAKALEEQEDEPSADQEKETAQQQEDESSEMSQDDLADEWAKALASEEEESFKDEQKQKSLSSQSKEAQFKDLTEDAKKKPEGTKRDLDFILDIPLTVTAQLGGTQLLINELLQLGQGSVIELNKLAGEPMEVLVNGKLVARGEAVVINEKFGIRLTDIISPVERIKQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6STE0</accession>
    <name>D6STE0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lytic transglycosylase catalytic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871305.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1295"/>
    <dbReference type="EnsemblBacteria" id="EFI33956">
        <property type="protein sequence ID" value="EFI33956"/>
        <property type="gene ID" value="Dthio_PD1295"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="1">
        <location>
            <begin position="73"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="192" mass="21696" checksum="22FA9D01CDBCEE69" modified="2010-08-10" version="1">MSFIQAAGIMGAVYLLLAGQPAWAGQGTIYYYQDESGTHHFTDLPTSQKYRPFAFFGRTQEKTPGQLEQSIVTYSRRYQVDPDLIRAMIQVESNFDARAVSLAGAQGLMQIMPETQKDLGLKDPFDADSNVEAGVRYYRWLLNRFQDTELALAAYNAGPSRVEKYGGIPPFEETVNYVDRVLDIYNNSKQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6STU0</accession>
    <name>D6STU0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1446"/>
    <dbReference type="EnsemblBacteria" id="EFI34106">
        <property type="protein sequence ID" value="EFI34106"/>
        <property type="gene ID" value="Dthio_PD1446"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="160" mass="18219" checksum="040DC41978D466DC" modified="2010-08-10" version="1">MRRTCLFPHSTKEVFMKEREKAKTLLDQLYAMESSPDYVLSSPEAAVIQLLPFRKKKTENFVVLFVDNKNRMICKKVVAKGTVDQIPVFPREIIRHAILKQASGIILGHNHPGGASEPSKQDRELTSKIKRIAMELGIRVLDHIIICDSGHFSFQENGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STV5</accession>
    <name>D6STV5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871470.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1462"/>
    <dbReference type="EnsemblBacteria" id="EFI34121">
        <property type="protein sequence ID" value="EFI34121"/>
        <property type="gene ID" value="Dthio_PD1462"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="7">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="5">
        <location>
            <begin position="93"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="6">
        <location>
            <begin position="561"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="675" mass="76264" checksum="C8415425A185E26E" modified="2010-08-10" version="1">MSKQEHGSSTHYAVHWQEEQYYYPGPEFIGQANCTDPEIYQRFSLDKFPECYKEFAELLHWDRYWHTTLDTSDAPFWKWFAGGRLNASYNCVDRHLQKHKNKTAIHFVPELEDEPIEHMTYQELYRRVNETAAVLQEFCGLKAGDRVTLYLPMTPELPVTMLACARLGIIHCQVFAGFSGKACGDRMWDSESDILITMDAYYRGGRLLNHKANADQAVQAAESAGQKVSRVLVWRRFPGRYSSAEPMVENRDYFLDELVKQNKNATIQPVSMPAEDILFLMYTSGSTGRPKGCQHSIGGYLSYVTWMSKYVQDIHPEDVYWCMADIGWITGHSFIVYGPLSLGASTVIYEGVPTYPDAGRCWRIAQELDVNIFHTSPTAVRALRKVGGDEPARYNYHFKHMTSVGEPIEPDVWRWYYEVVGKGRAVIVDTWWQTETGGFLCSTMPAIDPMKPGSAGPGLPGIHPVVYDDEGNELKPGEGKAGNLCIRNPWPGAFQSIWKDRERYIKSYYGKYNRDPQSKDWRDWPYMAGDAAVLESDGYVRILGRIDDVINVSGHRLGTKEIESAALSAEGVAEAAVVAMPDEIKGMVPDLYVSLKPGIDPSHELEKKLISTVADVLGKIARPAHVYIVPDMPKTRSGKIMRRVLASISNRRDIGDVSTLANPEIVEEIRQQVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6STZ4</accession>
    <name>D6STZ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871507.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1503"/>
    <dbReference type="EnsemblBacteria" id="EFI34160">
        <property type="protein sequence ID" value="EFI34160"/>
        <property type="gene ID" value="Dthio_PD1503"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1668121at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8879" checksum="68C4F636AB085437" modified="2010-08-10" version="1">MKKFDRITIDPELMNGQPCIRNMRLTVRRVVEAAALYPDWQDVLKEYPELETEDIRQALEFAASTLDDRAIRLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU53</accession>
    <name>D6SU53_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0140"/>
    <dbReference type="EnsemblBacteria" id="EFI32833">
        <property type="protein sequence ID" value="EFI32833"/>
        <property type="gene ID" value="Dthio_PD0140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="29205" checksum="4A58593BEEE946FF" modified="2010-08-10" version="1">MKAVILAAGLGSRLGKSLPKCLNHIGSETILSRQMRFFHKHGIKQVIVVVGYKKDLVMEENPEALFKYNPFFSSTNTAKSLLLALENLDEDVIWVNGDVVFDIEVLQEVVCAEYSVAAVDTKKCGPEEIKYTADFQGNLLEISKHVQKPWGEAVGINKVLQKDLAEFRQALKICHNNDYFEKGMEIAINTGVIFKTLDISSHRCIEIDFPQDLIQAQSMFENMTQLESLPRIPYDIKQNKHLHFNADFDFAKKQVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUC2</accession>
    <name>D6SUC2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetylglutamate kinase</fullName>
            <ecNumber evidence="8">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">NAG kinase</fullName>
            <shortName evidence="8">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argB</name>
        <name evidence="10" type="ORF">Dthio_PD0216</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871595.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0216"/>
    <dbReference type="EnsemblBacteria" id="EFI32902">
        <property type="protein sequence ID" value="EFI32902"/>
        <property type="gene ID" value="Dthio_PD0216"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 8" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI32902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="292" mass="31284" checksum="8EE4BFD117D35E12" modified="2010-08-10" version="1">MESEANKAKILLEALPYIREFYSETVVVKYGGHAMIDANLKKSFALNIILLKYIGLNPIIVHGGGPQIGSMLEQLKIDCQFREGLRITDQATMDVVEMVLVGKVNKEIVSLINQCGGRSVGLSGKDGPTIMARKMEMVINRKDAPPEIIDLGKVGEVVNINTGLIQAVQARGFIPIIAPVGVDEEGETYNINADSVAGAMASALKAKKLILLTDVAGVQDPSGEIISSLTRRQAAQVMESGVVAGGMIPKLKCCMECVEEGVQKAHIIDGRVENSIILEIFTRGGIGTEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUC4</accession>
    <name>D6SUC4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="7">3.4.25.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hslV</name>
        <name evidence="8" type="ORF">Dthio_PD0218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Allosterically activated by HslU binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871597.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0218"/>
    <dbReference type="MEROPS" id="T01.007"/>
    <dbReference type="EnsemblBacteria" id="EFI32904">
        <property type="protein sequence ID" value="EFI32904"/>
        <property type="gene ID" value="Dthio_PD0218"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1129370at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00248">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039093">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 7" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="19403" checksum="472E3E4C94063BAF" modified="2010-08-10" version="1">MTFEGTTILAVKKNGRIAMAGDGQVTMGQSIVMKHTARKVRRMYKDSVLAGFAGATADAFTLFERFEAKLEEYRGNLLRASVELAKEWRMDKYLRRLEALLVVADKENVLIISGTGDVIEPDDGIAAIGSGGPYALAASRALVDNTELSAEDIVNQGMQIAARICVYTNNNIVTEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUC8</accession>
    <name>D6SUC8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0222"/>
    <dbReference type="EnsemblBacteria" id="EFI32908">
        <property type="protein sequence ID" value="EFI32908"/>
        <property type="gene ID" value="Dthio_PD0222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="39" mass="4803" checksum="EADD405D0F38AD42" modified="2010-08-10" version="1">MEWLCEKMILFFIRRLDNCQIFFNEEDVRDKSGQETGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUG4</accession>
    <name>D6SUG4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate/ketoisovalerate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871637.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0258"/>
    <dbReference type="EnsemblBacteria" id="EFI32944">
        <property type="protein sequence ID" value="EFI32944"/>
        <property type="gene ID" value="Dthio_PD0258"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1777574at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="13"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="181" mass="18962" checksum="26C734114CABF19C" modified="2010-08-10" version="1">MSVYQDVIIAGFGGQGVMLMGNLLAVSAMHSGLHVTYIPVYGPEMRGGTANCTVVISDQEVGSPIVKSPGTLIAMNRPSMEKFQPRVKKGGTVVFNASQVEPGLADSSRLQARGVKANDIANDLGNPRLANMVALGAYVETTGIVSLQTVKDSLAQVIPERYHNLLPQNAQALEAGAGGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUI9</accession>
    <name>D6SUI9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871662.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0283"/>
    <dbReference type="MEROPS" id="M23.009"/>
    <dbReference type="EnsemblBacteria" id="EFI32969">
        <property type="protein sequence ID" value="EFI32969"/>
        <property type="gene ID" value="Dthio_PD0283"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="355"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="495" mass="55209" checksum="BA023AD44DB68A1D" modified="2010-08-10" version="1">MDYYIPSYGKSRIRYKRRRNRKYLFLAAACVVLALTFVFSGFDFIETRKHEQSGQENFKGLTIEQSIPEASGLQTAGDSSSSADTASPEIVPGNTGDALAQEAQAPGTGDILDAGDQKEVRAKLSEKNIRVSSGDTLMGLLNGEGLPRTQAHEIIEELSEVYNPRRIRQGQEITLVFREEDDQEPIFEAMNLKLDVDRDVRVEKCPENGLVATEEKRELDTRTVVAQAEITSSLYNAAVASDMPLRVLMQMIRAYSFDVDFQRDIRPGDSFEVMFKEKLDQDGNFVRGGSVLYATLKTRGRDLPIYRYETTDGEVDFFNPDGESVRKTLMVTPIDGARLTSGYGKRRHPILGYSRMHQGLDFAAPTGTPIMAAGDGVVEYAGRKGNYGNYIRIRHPNEYHTVYAHLSRFGSGVRRGARVEQGQTIGYVGSTGMSTGPHLHYEVHHRGSHVNPSTVDTPPGRTLEGEELQRFKAAREDLETLFASLKDEDTMARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUJ5</accession>
    <name>D6SUJ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871668.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0289"/>
    <dbReference type="EnsemblBacteria" id="EFI32975">
        <property type="protein sequence ID" value="EFI32975"/>
        <property type="gene ID" value="Dthio_PD0289"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1100576at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009501">
        <property type="entry name" value="UCP020269"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020269">
        <property type="entry name" value="DUF1121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="217" mass="24418" checksum="3968E4B774ABAC64" modified="2010-08-10" version="1">MGNEIKDYWDMRLLRVQENLRANNFDCRLAENPGRAKSLVLEEIIPEARPASISWGGSATFKETGLYDTLKDRTDMQVMDTFDKSRGPEANLELRRQALLADMFITGTNAVTEQGYLVNLDMIGNRVGALVFGPRKVIILCGRNKIVGDTDQAMERIKSYSAPANALRLQKKTPCIKTACCHDCESPERICNVWSITEKSFPKNRICVILINEDMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUJ8</accession>
    <name>D6SUJ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0292"/>
    <dbReference type="EnsemblBacteria" id="EFI32978">
        <property type="protein sequence ID" value="EFI32978"/>
        <property type="gene ID" value="Dthio_PD0292"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="323"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="651" mass="74541" checksum="3E4F8A814D727CA1" modified="2010-08-10" version="1">MKITANNISRSYSGQELFSRVSFELEPGRRLAVTGPNGCGKSTLLSMLAGLTHPDSGSINRPQGLRTGFVAQDLDDSDLKIPLLEFVLSVLPDWSQFWRQWKKAVAEDDRQGLEKLSRRQAEMEQSCGYNPEYRAEKILTGLGFEKSRFHLPLEHFSGGWRERARLSRVLLQGADLLILDEPTNHLDMEAVLWLENYLLDFSGILVLVAHDRFFLDRVATHVLHLGFDRPYFRPGNYSSFEKWHQETQILREKEREKISSEIKHLKSFVDRFRYKASKARQAQARLARMDSLESRKKELQSDRAGKRLNFSWPAPARASRVAVTCSELFFRHPQGPELLNNVNFQLFDGHKIALMGQNGSGKSTLFKLITGRAAPDSGTIKLGHNTRPAYFTQHQTETLAAENTVLAEIKRLSSRDLTEEEVRSVLGLFLLDETFWDRKVQSLSGGEKSRLILSSLFLTRANLLLLDEPTNHLDMESREALIAALQDFPGAVFMIAHDRFLLSRVAGEVWTLENGHTVEHGMGFDEYYQRVVLKDQTGPELSRETGPGGSGRNNSPHKEKKRQEASLRNRIYRELQPLKKEYSEKEHSLEQSLLRQEELENAMSLPETCQDPDRIRELSREYREVCAQNDSLMHRLEELEQQITQLEAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUM7</accession>
    <name>D6SUM7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="12" type="ORF">Dthio_PD0321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871700.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0321"/>
    <dbReference type="EnsemblBacteria" id="EFI33007">
        <property type="protein sequence ID" value="EFI33007"/>
        <property type="gene ID" value="Dthio_PD0321"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="211" mass="24374" checksum="DECC53D097190AAA" modified="2010-08-10" version="1">MGQKVHPYGFRVGYNKNWLSRWYSKTSYPEFIIEDRKLRNYLKSKLYHAGISRIELERAADKVRIIIYTSRPGIVIGRKGAEIENLRSDLKKKFQNEFSIEVNEVRRPETDAQLVAENIALQLERRVAFRRAMKRSVSLAQKFGAQGIKISCAGRLGGAEIARTEWLREGRVPLHTLRADIDYGFAQARTTYGIIGVKVWIYKGDILNEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUX8</accession>
    <name>D6SUX8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871833.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0018"/>
    <dbReference type="EnsemblBacteria" id="EFI32734">
        <property type="protein sequence ID" value="EFI32734"/>
        <property type="gene ID" value="Dthio_PD0018"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029118at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009387">
        <property type="entry name" value="HigB-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06296">
        <property type="entry name" value="RelE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039032">
        <property type="entry name" value="HigB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="11969" checksum="7872DD0976D4B845" modified="2010-08-10" version="1">MVFIETPTFTQMITEFMHDEEYLGLQNLLSENPERGDLIKGGGGLRKIRYALQGRGKSGGIRVIYYWMKDRNHIYFLVAYPKSRKDTLSSKELAVLRKLVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUZ3</accession>
    <name>D6SUZ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32749">
        <property type="protein sequence ID" value="EFI32749"/>
        <property type="gene ID" value="Dthio_PD0038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="56" mass="6422" checksum="AE800782BF0D4980" modified="2010-08-10" version="1">MPDVLIQKYFYPAVAEWLGESKETVEEMAEQYTDDQILSILAKNVIIQGGSVEKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUZ7</accession>
    <name>D6SUZ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871847.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0042"/>
    <dbReference type="EnsemblBacteria" id="EFI32753">
        <property type="protein sequence ID" value="EFI32753"/>
        <property type="gene ID" value="Dthio_PD0042"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="204"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="384" mass="43940" checksum="E4BFA61202BFB47C" modified="2010-08-10" version="1">MSVKLLKQNYVNKLECLDGKEKLRVYDEKLKGLMLEVRPTGIKTYFLKYKTPRGGYKQIKLGRNSFLSVEQARDIAAKVLADVAMGKDPQDEKKTLKVVPTFEDFAWNSYLPYVQGYKRSWKSDLSFLRTHLVPKFGKLHLDQITRDDIMAMHQERLKNGAAPASANRLVILLRYMFNLAIQWETPGVTVNPTKGVPLAEENNQRERYLTEEEVQRLCKAVKESENPLLEPIISMLILTGARKSEVLNAKWEDLDLERKRWRIPYTKSGKPRTVPLSESALEVLRSVPKVEGSEYIFPSPVTGKPFNSIYNSWNTARIKSGLEDVKIHTLRHSFASFLVNAGRNLYEVGKLLGHTQMRTTMRYSHLSDETLAEAVNTVPLKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJR6</accession>
    <name>D6SJR6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HicB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3572"/>
    <dbReference type="EnsemblBacteria" id="EFI36119">
        <property type="protein sequence ID" value="EFI36119"/>
        <property type="gene ID" value="Dthio_PD3572"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="47" mass="5366" checksum="610BF0A58731F73D" modified="2010-08-10" version="1">MFKYETIIYWSKEDQDYPAEVPELPGCMAHGDSYEAALANVKEAIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJZ0</accession>
    <name>D6SJZ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3649"/>
    <dbReference type="EnsemblBacteria" id="EFI36193">
        <property type="protein sequence ID" value="EFI36193"/>
        <property type="gene ID" value="Dthio_PD3649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="146" mass="16952" checksum="33809215A248363B" modified="2010-08-10" version="1">MVLQNTREILSELGYRVLDLEEKSNEESDGTGAKPLSLYFRTPEKGVVRLACGLVNSLFSEFIQLKKKGRDYPASEAEGHRCEQWCRDYDFLLHELSSQNIRIEENWRESPALEQCRVMEVSEEYLKVGKRVAPIVRTKRENIQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK44</accession>
    <name>D6SK44_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869369.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3704"/>
    <dbReference type="EnsemblBacteria" id="EFI36247">
        <property type="protein sequence ID" value="EFI36247"/>
        <property type="gene ID" value="Dthio_PD3704"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1272226at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="193"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="530" mass="60309" checksum="39D585E58F7AECFA" modified="2010-08-10" version="1">MKKKVQSIDLDQEQIDALLQRASKNELEETDLDIIKALVQAIQLLHQAVDDKAASIKRLLRTIFGASSETKKKLFQEDDQQNKDQKGSQDPLQKPPDEKPPKGHGRNGKDDYTGAAKCIYPHQTLKPGDICPLCGQGKVYPIKPKFRIRITATAPLTAKIHELKSLRCNCCLEVFTADPPEDIGEKKYDEPARSMIAILKYGSGFPFHRLEKLQESLGIPLPAATQWDLVEQTGTQLLPVYDELIRQAAQGEVVHNDDTNMKIQQLIKENKEAGPKRKGMFTTGIVSVLQGRHIALFATGRQHAGENLEEILKKRDHNLPPPIHMCDALARNIPKGLQIILANCLTHGRRNFVDILDNFPDECRYVIEQLAIVYKNDDMAKKQEMSAQERLVWHQQESAPVMSELKSWAWAQLEEKKVEPNSGLGKALAYMQKHWDPLTLFLREPGAPLDNNICERALKKAIQHRKNSLFYRTLRGARIGDLFMSFIHTCQLNKVNSFDYLTQLQKNIEEALAAPQKWMPWNYRENLPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK70</accession>
    <name>D6SK70_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase RecJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3736"/>
    <dbReference type="EnsemblBacteria" id="EFI36273">
        <property type="protein sequence ID" value="EFI36273"/>
        <property type="gene ID" value="Dthio_PD3736"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="236"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="320" mass="34505" checksum="13EDB1A0D136DCA1" modified="2010-08-10" version="1">MIPVPSELTRALKTGDNFLVTSHVKPDGDSIGSMSAAGHILKSLGKKFVLYNESGLPGKYTWLDLPAKIHNRPPDNNFDWIVVLDSASPERPGEYIADRINQVPTINIDHHPDNPDFGSINWVDPGFSSVGEMMSLVARQLNLELKGPLAHGIYLAIVSDTGFFSFGNTTPGVLEVTAQMVRQGLDPGQINPLITNQWSVGRIRLHGLALQRSEFVDNGRIGIICITKDMLKNTGTGPEDCEGLVNMLLKVSGVKIACTLREDDEGGVKMSLRSAGQDDVSRIASHLGGGGHRNASGGIINAPLQEAREMVIAGARRSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKM1</accession>
    <name>D6SKM1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0191</name>
        <name evidence="3" type="ORF">Dthio_PD2641</name>
        <name evidence="4" type="ORF">Dthio_PD2653</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32877">
        <property type="protein sequence ID" value="EFI32877"/>
        <property type="gene ID" value="Dthio_PD0191"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35232">
        <property type="protein sequence ID" value="EFI35232"/>
        <property type="gene ID" value="Dthio_PD2641"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35242">
        <property type="protein sequence ID" value="EFI35242"/>
        <property type="gene ID" value="Dthio_PD2653"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033S0H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343325at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="537"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="851" mass="98327" checksum="2740681A7051F564" modified="2010-08-10" version="1">MSRPVESFTCYPLGNRIIPSKKCLHCGEFLRTISYILSRRFWTTIAYYFGYIDMVLTDTARQYFLSIQFRIRQAAVRSPASVPFTYEDEPFFSAYQAITDVWKNRKPQRVVAESFNISRNTLKDWDHSFALYGTVALLPEISHEQVDPALERLVILVKLSRPHERANHALRLAKALGIEDASLEHIRQIQRSYGYGQRMDEADICFWSGLQHILESVIKQKEKPPARPVHNLHDRPGTFFNYQRDHLQHRVELFKALSKLEKKRQIRPVLQEFGMAPNRFYVLKNRYMLYGVWGLADLVQKGQTGEKISPQLELQIIEERLMDPSLSTAKMIKKLNLKCSRANVQKIYARWKLSRFKKPVAIRGVISSPVPAQVTEKQSPVEASAKSRFPDLVDTSGLKVNRSFLQFIKHLAYRKVVISNPGTLIVAPFLDQLGVIEAWHTYGPNSLRTSEITNNIIVNVMRIIAGFPSIHDFTLNADRSVAVASGLVLNPGKTRFYDAFDEIRFSHLQFLRNDASCRARELGIIEGKEIAIDYHCDPSDSRFPEDKALSKAPDKNGDMTYAHRPQILWDSMTNTIINIAYCEGKSRAPSALYRFCERNLFMIIDPDVIKEIYADSEYTGEKQLIYLTVRSESDITMCLKQNPKIKRWKEATIQQGVWQDYREQYRIASKDFILPETKKPFRFVVKQNKETSEIRCFGSTHTDYSPTKILDAYHIRWPVETGIKDLIENYFLNKPTGTSPEKVEAHYYCIMLARLAVDYFRSQLCIPQWQSPEDWKCVLSTIRTSIFSNQNCELSLDDSGDLLITYLDGDRQGIKKRLAELLTSRKETGLNRVSWWGNRGVQIQVKDQYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKM6</accession>
    <name>D6SKM6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">Dthio_PD2648</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868371.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2648"/>
    <dbReference type="MEROPS" id="M48.002"/>
    <dbReference type="EnsemblBacteria" id="EFI35237">
        <property type="protein sequence ID" value="EFI35237"/>
        <property type="gene ID" value="Dthio_PD2648"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="83"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="295" mass="32168" checksum="AE8496D7117BD7C5" modified="2010-08-10" version="1">MKRVALFIGTNIAILVVLLIVTSILGVNNYLDETGTGLNLTHLLIFAAILGFGGSFISLVISKWMAKRLTGAKVIDRPNNEVENWLLQTVRRQASRAGIGMPEVAIFDSQAPNAFATGMKRDAALVAVSTGLLKNMNQDEVEAVLGHEISHVANGDMITLTLIQGVVNTFVIFLSRIVGHFVDRVILKNEEGHGLGFFVTTLVAQIVFGILASTIVMWFSRQREFRADAGGAQLAGSGKMISALEKLQKGAQEPLPDQMASFGINGKKDYGWKMLFMSHPPIEHRIEALKRSNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKQ8</accession>
    <name>D6SKQ8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">Dthio_PD2680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868402.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2680"/>
    <dbReference type="EnsemblBacteria" id="EFI35269">
        <property type="protein sequence ID" value="EFI35269"/>
        <property type="gene ID" value="Dthio_PD2680"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="125" mass="14517" checksum="960647A4FFE5197D" modified="2010-08-10" version="1">MILDTDVLIWYLKGNQNAFRIIEESEYFYISVVTYMELVQGMRNKQELATLRKALHAWKTQILYISEEISIKAMFYVEEHFLSHSVQLADALIAATAQVHAQPVLTGNDKHYRALKGLEIKKFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKV6</accession>
    <name>D6SKV6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868449.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2732"/>
    <dbReference type="EnsemblBacteria" id="EFI35317">
        <property type="protein sequence ID" value="EFI35317"/>
        <property type="gene ID" value="Dthio_PD2732"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1986623at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="261" mass="29746" checksum="AD65C6EA96780AE8" modified="2010-08-10" version="1">MLFHLRILVHAIMQRKKYLALILLPPFIFLVVQAFIPHRYHMTQDLAVEEGAMFVLGQNPLETVRLESLVQRPEILFTDTLALMDLRNHLLITEAAHRPEWSEWLPSTFAVFVQRAIYENLSLTMKDGHTLSLEYHGPDRDLGAALINFYSQRLMAGARRAAERSLVQLTLETGEPLGGRSALGKVYVEAPMQVSTSRVLYSRERAGPALWTLGVSTVIVLSFMCLAQYRRPRLYSVRQASRCLDARVLGSFPDLNKIKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKY2</accession>
    <name>D6SKY2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5-oxoprolinase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">3.5.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2758"/>
    <dbReference type="EnsemblBacteria" id="EFI35343">
        <property type="protein sequence ID" value="EFI35343"/>
        <property type="gene ID" value="Dthio_PD2758"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="327092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="53"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="259"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="728" mass="78772" checksum="20E7919AFC743969" modified="2010-08-10" version="1">MFPHSTAGKISRLELKLFSALPDTPAKKTKFIQQLIPKGNISIAMQSCDPVIIGVDTGGTFTDFIYHLGGAWVVHKTLSTPDDPSRAVLEGLEHIAPEGRTRPVESHSVGPPGAALGRVKVVHGSTVATNAVLERKGVRTAIITNAGFEDVIEIGRQNRDQLYNLFYRRPQTVVPPGLRFGLPARMDASGKEIQPMDLEVLSSIKKRLKELQVQSVAVCLLFSYLNPEHEQMVYRELADLNIPVSLSHCILPEFREFERLSTTVVNAYVAPKMSGYLQRIQDRLHPAPLRIMQSNGGSISAAQAMQEPVRTILSGPAGGVVGAVETAKRAGLEKIITLDMGGTSTDVCLMDKALPLSTETCLSGFPLKVPMLDIHTVGAGGGSIARLDAGGALKVGPESAGSDPGPICYGRGSEITVTDAHLFLGRLQADRFLGGGMTLDRKSLDAAFEELSGRAGLEPMDLAQGVLSVADTSMERAIRVISVEKGFDPREFTLVSFGGAGGLHCAELARMLSMPRVLVPANPGVLSAMGMVLADVIRDYSRTVMLGHGKATHGRLQKLFGPLEEQAREEMLQEGFNEDSLSLHRSLDMRYQGQSFEIMVPWRMGQDPGDGFEELHRQKYGYIHQGRDMEVVSLRLRAAGTPAKPALQPSTPGDEQVSDKAFYGQTQLYFEGGFISAPVLDRNELLPGNGFAGPAVITEYTSTVFVPPFARARVDNWGNIVLDILDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL03</accession>
    <name>D6SL03_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyanophycin synthetase</fullName>
            <ecNumber evidence="8">6.3.2.29</ecNumber>
            <ecNumber evidence="7">6.3.2.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyanophycin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD2779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13277"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.29"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23888"/>
            <dbReference type="Rhea" id="RHEA-COMP:13732"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.30"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.29" evidence="8"/>
    <dbReference type="EC" id="6.3.2.30" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868496.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2779"/>
    <dbReference type="EnsemblBacteria" id="EFI35364">
        <property type="protein sequence ID" value="EFI35364"/>
        <property type="gene ID" value="Dthio_PD2779"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071161">
        <property type="term" value="F:cyanophycin synthetase activity (L-arginine-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071160">
        <property type="term" value="F:cyanophycin synthetase activity (L-aspartate-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009059">
        <property type="term" value="P:macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011810">
        <property type="entry name" value="Cya_phycin_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044019">
        <property type="entry name" value="Cyanophycin_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18921">
        <property type="entry name" value="Cyanophycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02068">
        <property type="entry name" value="cya_phycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="221"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="888" mass="98097" checksum="1C5317C2D586DD3F" modified="2010-08-10" version="1">MKILESRALRGPNYWSSRRHNLIVIRVDLEEMEKYPSNTISGFPENMEKLIPSLYEHRCSRGYEGGFLERLREGTWMGHVMEHVALELQILAGMQCGFGRCTWDGEEGIYSVVFSYEEERAGFYAAEAAFEIVRAMIKGESYDLQKDIQALREIREQERFGPSTASIVHEAKKRHIPVLRLNSYSLVQLGWGIHQQRIQATVTGRTSSIGLEIAFDKEETKNMLHNNGCPVPYGLVVCSAGEVEAAVCRVGFPVVVKPVDGHHGQGATINVQNPENALAAFEAAREYSSRVIVEKCIKGSDFRLLVINYKLAAAAKRVPAHVTGNGRSSIQELIKEVNRDPRRGYGHEKMLTEITVDDMTKRLLELEGLSLDSVLSPGRTLYLKTTANLSTGGVSEDVTDTVHSYNVFLAERVARIIDLDVCGIDVIAPSLAEPLSETGGAIIEVNGAPGFRMHLSPVAGQPRNVAEPVLDMLFPLDHPGRIPIISVTGTNGKTTTTRLIAHIMHMSGKKVGYTTTDGIYIQNRLLYKGDCSGPDSARFVLRDPTVDYAVFETARGGMMRAGLGYDLSDVGVVTNVASDHLGLYGIHTLEQLTRLKCLVAENVQPSGYAVLNADDDYVYSMQENVSCNTAFFSMNAGNPRIKKHCSSGGTAAVYDEGDIILRKGDWSMLVDRVINIPLTYFGKAAFQVQNVLAACLAAFVQEVKVEEIRLGLQTFAPSSAQLPGRMNIFEFEKFKVLIDYAHNPSSMEAMGRFVSSLGMGVSTAILAGTGDRRDKDLQDYGRVAAEYFDRIIVWEDQDYARGRDSMKVMQLIQEGAASSSKKARVLSILDEDHAVDHALQEALPEAIICIFTGRIEAMTAKIKALREKELDLIIAREDIPNISPELRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL47</accession>
    <name>D6SL47_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868540.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2824"/>
    <dbReference type="EnsemblBacteria" id="EFI35408">
        <property type="protein sequence ID" value="EFI35408"/>
        <property type="gene ID" value="Dthio_PD2824"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1085290at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011460">
        <property type="entry name" value="DUF1566"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07603">
        <property type="entry name" value="DUF1566"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="334" mass="37811" checksum="9A9C9A075B169884" modified="2010-08-10" version="1">MTLNIIRTGLGKCYDVYGREIPCHGTGQDAAFRLGVAWPSSRFVSLSKNRVRDELTNLEWTLKANFFDFPLTWQQALDEVKEMNREGFDGYNDWRLPNRREIRSVISHGQRKPALPAGHPFTDVFLGWYWTSTSSALAPAYAWYVHLEGARMFYGGKEQRYLAWPVRGNSRHIPCTGQTECFNTRGEVIECAGTGQDPDISAGQPWPVPRFSRQGREITDHLTGLIWLDPGESAGRAVSWQQALDTVQQLKGDSEWRLPNINELESLVDASAHSPALPEEHPFTDLLDGYWSSTTSFFEPDWAYALYLKKGAVGVGFKPDSGFYVWPVRSLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL55</accession>
    <name>D6SL55_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipopolysaccharide 1,2-N-acetylglucosaminetransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2834"/>
    <dbReference type="EnsemblBacteria" id="EFI35416">
        <property type="protein sequence ID" value="EFI35416"/>
        <property type="gene ID" value="Dthio_PD2834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="57" mass="6884" checksum="5341D83F54AFCA1A" modified="2010-08-10" version="1">MDAFAERINTLAETHSCEAREIGEYNRDKVEQMFTLERMVREYEDLFQQVLEKKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL69</accession>
    <name>D6SL69_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Biopolymer transport protein ExbD/TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868562.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2850"/>
    <dbReference type="EnsemblBacteria" id="EFI35430">
        <property type="protein sequence ID" value="EFI35430"/>
        <property type="gene ID" value="Dthio_PD2850"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1537812at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="15137" checksum="40BDA1088E7F776E" modified="2010-08-10" version="1">MKLNRPLLKQARIEMLPLIDIIFLVLVVFIYAMLSMAVHRSLPVDLPLSSAVEIDPDVRLTITVQADRSIYLDKEPVNLDELTSLLQDKVAAGKDPEVTLVADQDLVYQQLFAVLDRIKEAGIANISLQAEEASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL74</accession>
    <name>D6SL74_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35435">
        <property type="protein sequence ID" value="EFI35435"/>
        <property type="gene ID" value="Dthio_PD2855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8841" checksum="47F51EE90F791D59" modified="2010-08-10" version="1">MYEMLALKINYKRRQAMTLKSSISSLDKQTQRVLQQKIDYLNSKNPVNFDEYLRCVSIIRKSFLKKKCAESDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLD4</accession>
    <name>D6SLD4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the P(II) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868627.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2918"/>
    <dbReference type="EnsemblBacteria" id="EFI35495">
        <property type="protein sequence ID" value="EFI35495"/>
        <property type="gene ID" value="Dthio_PD2918"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2021322at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="131" mass="14402" checksum="ED42B2412486C3B3" modified="2010-08-10" version="1">MKEVMAIIRANKINQTKKALVAAGLPSFTAVKCMGRGSRPVDFEMLEAMNRSPEDAGEILPILSQGGRLIPKRMLSLIVPPQKVQEVVDIIMQENSTGNQGDGKVFVLPISDVLRVRTEEEGLQAIDEMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLE9</accession>
    <name>D6SLE9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868642.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2934"/>
    <dbReference type="EnsemblBacteria" id="EFI35510">
        <property type="protein sequence ID" value="EFI35510"/>
        <property type="gene ID" value="Dthio_PD2934"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="719" mass="80543" checksum="4E16E42D0CB0A2CF" modified="2010-08-10" version="1">MLNADNLKDYLKEIEEQLQNDFQRKTLDTFAVAYRTGRANAFAGMDIDSLVKEIAEAKDSSLSRMDALYKEFKKNAEALGVKVHLAKDPKEANEIIASIAKENNCKNIVKAKSMTAEEIHVNTHLEKEGYRIVETDLGEWIIQLRNEPPSHMVLPAIHLSRYQVADLFEGVTKKKQDTDVHKLVKVARRELRKEYAYADMGITGANFAISETATLGMITNEGNGRLVTTLPRVHVALVGLEKLAPKLRDALRLLKALPRNATGQQITSYVSWITGPNECKSAPDNKKVMHVVFLDNGRRKLSTDRNFSQILRCIRCGACANVCPVYRLVGGHKYGYVYIGAIGLVATYFFHGKDKARLLVQNCVNCGACKEICAAGIDLPRLIKDIHARIQDEDGHPPKSKLLGMVMKNRRLFHSLLKNMRFAQLPFADTEARYVRHLPSIFMKDQDFRKLPVIASKPFRDRWEDLKPRVTQPRKKVALFSGCAVDFIYPEQMEAASKILSKGRGIAQEHPMDQTCCGLPALMMGEKKAAREVARQNLEAINPDDFDHIITLCASCASHLKHGYTKLLEKDKDLKDRLKAFTGKIIDFSSYIRDEMRLSSMLFEHSGKKVGYHSPCHLCRGLEVREAPRKNIALAHEYVPTDEEEVCCGFGGSYSMNFPAVSRTLLAKKMANLQAGQVSAVATDCPGCVMQIRGGMAKDGKDIKVKHIAELLAEQLKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLI7</accession>
    <name>D6SLI7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2972"/>
    <dbReference type="EnsemblBacteria" id="EFI35548">
        <property type="protein sequence ID" value="EFI35548"/>
        <property type="gene ID" value="Dthio_PD2972"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1226158at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="359"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="412" mass="47381" checksum="48F96A728E546977" modified="2010-08-10" version="1">MHKFVFVFISLLIALCIFSGCRDNKPAIYFSDVPSRDFSTAPEINIPPKDAVNPNKLPLHVTSAAEALARKIIGCTSSFSQAEFSTDGAHSWLFESLNEQDFQVSSIKIMRYSKDSKDMTVSLEMYMHFQDRMGRTASFLVQADYKRLADKIVIERSDIQEKSPLFPRVQAFILYEEELRSKDLSDMTFKQFYYWTLDRALSLTPDDEHRRTKLNIDRMSVYQRMSMMPEAQTEKYSIVVLTMDRLASNSGFKIEVSGTPHGTNWIEEVTYHDFQGWRAGIFSLSFILDWEIYYVRALYGAKQENWTAKNKLKLVGLFSTERDYTHWPAFDGRTALQGPIARLGIMLEPENADDAGMIASRLHELGFLKNADNKCEEKLEEALKIFQHTRGLNPSGQWSAETQKKLFHDTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLK5</accession>
    <name>D6SLK5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868698.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2992"/>
    <dbReference type="EnsemblBacteria" id="EFI35566">
        <property type="protein sequence ID" value="EFI35566"/>
        <property type="gene ID" value="Dthio_PD2992"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="239" mass="26569" checksum="751230AC2784CB2C" modified="2010-08-10" version="1">MKALILAAGPGKRLKAQTKEHNKCMFSVFGKPLIEHSLITAASLKEIDEIIIVVGHMAEQIINAYGTKYQDKTVKYRIQSPLKGPVGAIEAALLDLESEDFLLLFGSELVVQGRYQEMIKDFYHHKLSVSCGVVPASEKVPYSVIQDEKGFIYRLVEKPARLVNKWMGTGSCVFQSSALEYSASVPVHPVARERTLPDLIQTAVDNGHPVKSFNLGNDYVSINTKEDLDALEKPVTFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLS0</accession>
    <name>D6SLS0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868760.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3060"/>
    <dbReference type="EnsemblBacteria" id="EFI35631">
        <property type="protein sequence ID" value="EFI35631"/>
        <property type="gene ID" value="Dthio_PD3060"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_C554" evidence="1">
        <location>
            <begin position="35"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="155" mass="17288" checksum="A7CADD8D51DDD1DC" modified="2010-08-10" version="1">MKYMLVLVSAAMVLFLGLGLSLGDTFEKEYVGSDACMDCHIEEYENFMEYASKSNSDENVQLMLDKLTPDEQRECYECHTTGYGEPGGFISFEDTPELGHAGCEVCHGPGSEHAFTGDPHLIEADLNIEEHCAPCHDDERVRNINYKPLLYSGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLS3</accession>
    <name>D6SLS3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868763.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3063"/>
    <dbReference type="EnsemblBacteria" id="EFI35634">
        <property type="protein sequence ID" value="EFI35634"/>
        <property type="gene ID" value="Dthio_PD3063"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935037at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="PTHR43146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="175" mass="19244" checksum="BC96F6816C060ABB" modified="2010-08-10" version="1">MKNLNILITGSPGTGKTTLVRSLCHSLKDFNPAGFYTQEIREKGKRLGFELVSLDGPGMILAHTDLPGDFQVGRYGVDVSGFDRFLKRLRLDNTQTGLIVIDEIGKMECFSDNFAALVYTALDSPIPVLATVAAKGGGLITAVKKRPDVEVVELTLHNRNELAPELERRIRNFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLT5</accession>
    <name>D6SLT5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="10" type="ORF">Dthio_PD3075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868775.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3075"/>
    <dbReference type="EnsemblBacteria" id="EFI35646">
        <property type="protein sequence ID" value="EFI35646"/>
        <property type="gene ID" value="Dthio_PD3075"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="223669at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="4"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="45305" checksum="E7E128F1451FEA7C" modified="2010-08-10" version="1">MSLEQQVKDVSRKARDAGRLMARADSEKKNRALEILADLLEQNSAKIFEANIKDIQEAETRGLDKARVERLKLDSGAVKSMAGACREVAAMHDPVGEIESMHKRPSGITVGRMRIPLGVVAIIYESRPNVTIDAAILCLKAGNAIILRGGSEAANSNEALAGLISTALAQSGLPESGVCCLPSTDREAVRIMLKQDDCIDVVIPRGGEGLIRAVVQDATMPVLKHYKGVCHIYVHNDADLDRAVDIIQNAKVQRPGVCNALECLLVHSDVAGNFLPRLSYRLAGDQVEYRACERSLPLLGDAARPASPEDFGCEFLSLTMAVRVVDSQDQAQEHIDKYGSGHSEAILTRDYSSSMRFMREVDASAVFVNASTRFNDGGQFGLGAEIGISTSKLHAYGPMGVRELTSTKFVVLGEGQIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLW7</accession>
    <name>D6SLW7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fumarate reductase cytochrome b subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The fumarate reductase enzyme complex is required for fumarate respiration. This subunit anchors the complex in the membrane and binds a diheme cytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868807.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3107"/>
    <dbReference type="EnsemblBacteria" id="EFI35678">
        <property type="protein sequence ID" value="EFI35678"/>
        <property type="gene ID" value="Dthio_PD3107"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030YQC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1073274at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004224">
        <property type="entry name" value="Fum_red_B_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000177">
        <property type="entry name" value="Fumar_rd_cyt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000177-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="217" mass="24558" checksum="8F8433B1B530022D" modified="2010-08-10" version="1">MQYQDTMFSPASGSRAALLDLVQMLTGLALVVFMYLHALFVASILLGPQVFNTLADFFERYYLAQVGGPLLALVFLIHFFMAARRIPFSQQDQKKVLSFSRLLAHRDTWLWTVQVVTAMIILIMGAIHIWVVLTDLPITADKSAARIQTGFWLGFYLLLLPMVELHVGAGWYRLGVKWGVIKSSARKKAKRAEYYITGFFILLGLITLARFMFVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLX2</accession>
    <name>D6SLX2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3112"/>
    <dbReference type="EnsemblBacteria" id="EFI35683">
        <property type="protein sequence ID" value="EFI35683"/>
        <property type="gene ID" value="Dthio_PD3112"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="180" mass="19481" checksum="3625BDAD6B5BA435" modified="2010-08-10" version="1">MSREIKLSTPLQEEDVLHLRTGDKVLLSGHIYTARDAAHKRLLQDLDQGIEPPFNLQGAVVYYVGPTPAPPGRVIGSAGPTTSSRMDAYTPRMHQLGVRATIGKGRRSQEVRRVLQEQKAVYLGATGGAGALLSRCITGSRVLAFEELGTEAIRELEVLDFPLLVVNDAFGGELYVTAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLZ1</accession>
    <name>D6SLZ1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ORF">Dthio_PD3131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868831.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3131"/>
    <dbReference type="EnsemblBacteria" id="EFI35702">
        <property type="protein sequence ID" value="EFI35702"/>
        <property type="gene ID" value="Dthio_PD3131"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="10"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="401"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="631" mass="69976" checksum="31CB7B4816F641BE" modified="2010-08-10" version="1">MIKELPEIFDLIIVGAGHAGCEAAHAASKLGLATLVLTNNIDRIGHLSCNPAIGGLAKGHMVKEIDALGGIMGLWADESGIQFRRLNTRKGPAVQATRAQMDRSRYLFSAQSTLFSLDHLYIMEAFAEDLLVTSGRIRGVRTAFGEDFYAPAVLLTTGTFLQGQIHVGLRSSSGGRLGDPASAGLSHSLRKLGLDLGRLKTGTVPRLLKESIDFSVMQEQHGDDPPPRFSFRGAPRTLRQIPCHITYTSSSTHECINAGLDRSPMYQGLIHGTGARYCPSIEDKVARFPEKERHQIFVEPEGLDSHEVYPNGISTSLPLDVQKKMLQTIPGLEKAIIVRPGYAIEYDYIHPTQLTPHLETRAVQGLYSAGQINGTSGYEEAAAQGLWAALNIYARSHGTDFILKRDQAYMAVLVDDLITRGTSEPYRMFTSRAEYRLLLREDNADERLTPLGRELGLVDDAYWKIFTARQQQMQSLKEALRSMVIRPDQSTVKILEQIGAHPPKRSASLADILKQPSISIRELKPLWSGLDDYEDAILERVQTDIKFEGYISRQREMAERIRHLEDTGLPRDLDYTRVSGLSREAVEKLSAIRPETLGQAGRISGITPATLSALQIYLKMGKKDPQQDKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM18</accession>
    <name>D6SM18_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YHS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868858.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3158"/>
    <dbReference type="EnsemblBacteria" id="EFI35729">
        <property type="protein sequence ID" value="EFI35729"/>
        <property type="gene ID" value="Dthio_PD3158"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1964436at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="9945" checksum="ED630223D63DDC8F" modified="2010-08-10" version="1">MMKFIVIAVVLFILYKLLTNDQKKKKDAQLKEKEKLAASGIMVKDPVCGTYVDKDSDVRIKKDGQVYCFCSYDCRDKYLKKIKPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM35</accession>
    <name>D6SM35_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868875.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3175"/>
    <dbReference type="EnsemblBacteria" id="EFI35746">
        <property type="protein sequence ID" value="EFI35746"/>
        <property type="gene ID" value="Dthio_PD3175"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="516" mass="58649" checksum="743045BCC0268B3A" modified="2010-08-10" version="1">MLEHYSPKRVLKTFRFLLTVFLIFRQKQSLLGIKPLEPGDLKAVILELGVSFIKLAQVLATRADFFTEDYLRQLRAIHDEVEPMPEKDLSSMLSRAYSREFPFASFDRHPLASASIGQVHQAELKDGTRVAVKIRRLDIEKKVRIDAGLLKFFLKVFQPFFTSHTRNSLQAVLNEFSAMLLKEVDMAMELDNLRKFKETYENETISMPEYYPKYCSHDALVMSFESGLRVDDKAGIQQRGIAFKKVMENLISWYASQMLVKGLFHADPHPGNILVQDDASLTILDFGMVKRLPNSTRVAMIELVKSAHERDFEMFASACERMGLVTSTASPDEIRELAERMFDIFSNVNLSAANMQALAFEVLDSMKDFPFKLPQEVVYVMRASTLIEGLGTTYIENFNGIKDILPVLQNRLPEALGMEEGFASVARREITALPFTISRFKSVLTDMSDGNLNVRLSRKTLEALDEHIRALLRPLGVGLVLLAGSFFILFLEFHLSRVLAGFVFLVGAFKIWSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM65</accession>
    <name>D6SM65_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868905.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3211"/>
    <dbReference type="EnsemblBacteria" id="EFI35776">
        <property type="protein sequence ID" value="EFI35776"/>
        <property type="gene ID" value="Dthio_PD3211"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="301791at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018821">
        <property type="entry name" value="DUF294_put_nucleoTrafse_sb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005105">
        <property type="entry name" value="GlnD_Uridyltrans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03445">
        <property type="entry name" value="DUF294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10335">
        <property type="entry name" value="DUF294_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="169"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="234"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="636" mass="73252" checksum="91F831A624DA4423" modified="2010-08-10" version="1">MNEQTVKFLSSVEPFDILPENEISRAAQNLTHAGFPADRTLFVQNKSILNHIYIVSSGKMEKFILEEEDKKLREILGEKSIYGGLSVLFNKSISIRTVRTLEESNIYLLPKEHFLDICSRYPEFIQHFARNFCSHMLQAPYQALITGSMDDEKQVSPSAFLNLKLKDIFSREFASCSEYASIKEAAALMRDQKKSAVVTMNALDQSIGLLTDNDLRSKVVSQNYPVHNPVKEIASRPLITLPEDSQVFEAIIMMMKHSVKHLVITDDRDNVLGIATEQDLLLAQGRSPVYLMREIQLAQTLEELKHRQLQVPGMIKSLMDSGARAGHLNRIITEISDAILKKIAAWTIDEMGHPPARFAFMILGSEGRKEQTLKTDQDNAIVYEDVEPEREEEVRKYFLELGDRICTRLDEVGFSFCNFGIMARNPKWCQSLGQWKTYFWDWIHQVEPEDLLHSSIFFDFRLGYGDKGMVNELRQYLFESLGKWKGFFRHFAENALHFKPPLDFFGNLVIKNTKEKKNCLDIKQPMQLLVDFARLYALKYFIAETNTLDRLEKLRQQGVLSGQDFDELSHAYGFMMLLRLSHQARMIVDDGKPADNLIQPKMLTYIDRQSLKEAFKRIKTAQGKMRMELTQDIGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM73</accession>
    <name>D6SM73_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3219"/>
    <dbReference type="EnsemblBacteria" id="EFI35784">
        <property type="protein sequence ID" value="EFI35784"/>
        <property type="gene ID" value="Dthio_PD3219"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="143"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="31609" checksum="C5D8D5CA8EBF2E72" modified="2010-08-10" version="1">MGVRGPMKNTAIIGAGVVGTAMGYLLSNAGYNITGIASRSLESAVKARDFIGQGEASTDLAGTARSAGIVLITTSDDAVRLVCEDIAGRDGFRPGSLVIHTSGALSVEALASAKHKGAVTVSMHPLQSLPSVQEAIKNMPGSYFCLESEDETALDTARDMVRVFQGKELNIQLGGKPLYHAGAAVVSNFFVATIGFGLQLHESAGIDRQDSLNALLPLIQGTLKNIEKIGIPAALTGPIARGDAQTVEDHLAAISRESPDLLGLYCELGKYTVKLAREKGTLKEHDAQKIIEILRQYSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMC2</accession>
    <name>D6SMC2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional protein PutA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="2">Proline dehydrogenase</fullName>
                <ecNumber evidence="2">1.5.5.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">Proline oxidase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="2">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="2">P5C dehydrogenase</shortName>
                <ecNumber evidence="2">1.2.1.88</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Oxidizes proline to glutamate for use as a carbon and nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the proline dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2"/>
    <dbReference type="EC" id="1.2.1.88" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868962.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3269"/>
    <dbReference type="EnsemblBacteria" id="EFI35833">
        <property type="protein sequence ID" value="EFI35833"/>
        <property type="gene ID" value="Dthio_PD3269"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14333at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006561">
        <property type="term" value="P:proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025703">
        <property type="entry name" value="Bifunct_PutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000197">
        <property type="entry name" value="Bifunct_PutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pro_dh" evidence="9">
        <location>
            <begin position="132"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="554"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="759"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 5">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000197-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1203" mass="136401" checksum="3AB826025447CCDC" modified="2010-08-10" version="1">MPSHHEQILQDAVNLAVRWQNRANTLLTSEEKSIQEQMNRLLTHPMDKVVLTRLIDQCFRSHDHERVADQVNHLLSVYGVPDFFSRVERLLIQMFVGMGRHFPHFSVPRLVQQMRNSSSRAIIPGEEKALHNHLEKRKKQGVRMNINHLGEAVLGEDEAAHRLETYIQDMQNPDVEYISVKISTLYSQISSLAFEHTVEIMKDRLSKLFRVARENYFVRSNGQKVPKIVNLDMEEYRDLEITYEAFIRTLEQDEFRDYSAGLVLQAYLPDAFSKQKKLTEWALKRVAAGGAPVKLRIVKGANLEMELLESSHFNWPLATYDNKLDVDANFKRMLTYGMEPERIQAVHLGVASHNLFELAYAHELGHVMEVTDWFWFEMLEGMADHVRRSLQESVKDILLYAPVASREQFINAIAYLIRRLDENTSPENFLRYAPHLTTDSKAWSFLKNQFLQSCRHMQDAPDSPNRTQDRNEENFPEDMGSYWTRTFRNEADTDWSLRSAPVWAGSIRDKWMNDGQKPPLRIPVVVDGEEIFNGSETREIVDVSTLDEAKDRKVVSAVYCLADSGNIQRAIQVAKDDPDGWRNTSLDERHRILDLVSHELRRARGDLIGSAAANWGKLFTESDPEVSEAIDFTELYPHSARIYKDLNVSCSPKGTGLVIAPWNLPIAIPCGGIVASLAAGNTVLFKPASASVLVAWELVQCFYRAGVSRKVLQFIPCSGSTAGDELTKHPDVDYIILTGGTDTGMHILKNRPDVFLAAETGGKNATIVTSMSDRDQAIKNIIHSAYSNSGQKCSATSLVILEKEVYQDELFKRQLVDAARSCSTGSAWEFQNKVGPLIAPPQKDLLRALTELEPGETWVLEPRPSPANPYIWSPGIKWGVQPGGYTHMTEFFGPVIGVMRAENLEQAIELVNMTGYGLTSGLESLDQREQEIWKKGVKAGNLYINKGTTGAVVLRQPFGGMGKSALGAGIKAGSPNYVYQFMDFTETGYPESGAVQQESHLLRTVNEWEIDLRWNRIHEDIAEDITRTIYAVKSYLYQWEKEFSKEHDYFHLRGQDNVLRYLPKGRVAIRVHPDDSLFEVLGRSAACIVTGCKPVISLPAGLENAVTGFLDSTRGRLFNRDVQIIEQTDEELCEMIQELDRIRYAGPERVPEVVYARAAETGFYISRTPVFMEGRLELLQYLQEQSISNNYHRYGNLGERGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SME9</accession>
    <name>D6SME9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868989.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3299"/>
    <dbReference type="EnsemblBacteria" id="EFI35860">
        <property type="protein sequence ID" value="EFI35860"/>
        <property type="gene ID" value="Dthio_PD3299"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="335" mass="37685" checksum="0A5EBB99BBD9C10C" modified="2010-08-10" version="1">MQLDEFISTIEKDAPPGQALEWDNSGMQVATSRSHIKTVGMCLDPLPENISQALEKNCDFILCHHPLSIKPRLPDKVDTFHHVLSLLFQADTALYSAHTSLDVNSSGPVSWLLREMDLENPRIIMPTGRVHHEQLRFHPPVELSGRKKALLHDVEQIYEENGHISRVLVRSELADRFLQRLEADAGPVDCQRRYSPGDDMIFGLGLMGSWKEKVSFFSFMDRLQSVLGMENFVCMGQRPAYVQKVAYCPGSGGDLASRAFAMGADVFLTGDVKYHQALDIQGTGFVLDVGHFILEEKMMYSWYQSLERTVPGINFHYIKGKTPMHISGVHALKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMH0</accession>
    <name>D6SMH0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869010.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3320"/>
    <dbReference type="EnsemblBacteria" id="EFI35881">
        <property type="protein sequence ID" value="EFI35881"/>
        <property type="gene ID" value="Dthio_PD3320"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1239195at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="157"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="221"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="477" mass="51932" checksum="B2C82D13EB9F8311" modified="2010-08-10" version="1">MDNKILIEAKDFLDAALDSDDQGRQELISRLESLLEAGDHDSIRDFFYSLHPADGAQALELFSPEKACAFITLLNNETQAQIFNYLPPHFETRMASCLGRAQLARIIGAMSHDERADLYNRLTSEQQEEVLPALAHAEREDIRRLASYSEGTAGAVMTSDYAALSPDITAREALEKLRREAPDKETIYQCYVIDENRRLVGVISLRELLVASPRSLVSEVMNQQPIFAHARDNAEEVASTIAKYDLMAMPIINGDDKLVGIVTFDDVHDILEEEATEDFHRMGSISGHGESLVGVNFREASPWLIIQKRLPWLLALVFVNLLSGAGIAFFESTIEAVVALVFFLPLLIASAGNAGSQSSTLMVRALATGDVKASDWLYLLGKEVGIALTLGLGMALAVSMVGIFRGGPEVAIVVGLTMTVVVLFGSLVGCLLPFLLARMKVDPATASVPLITSIADIGGILIYFSIATWLLEVPAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMH6</accession>
    <name>D6SMH6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3326"/>
    <dbReference type="EnsemblBacteria" id="EFI35887">
        <property type="protein sequence ID" value="EFI35887"/>
        <property type="gene ID" value="Dthio_PD3326"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="391" mass="46217" checksum="B2848D37403370EF" modified="2010-08-10" version="1">MKTDMEQTHYEGDELKQDPGTAVPDITEMDQRILSEIVCVQITPEEMHKIIMPVKQQPHQKTVLAVHWHPEYIPMELIKKRIENTFPNKEQELIIPTQHNELLTYDDQYHGAEIDCYSRGFQRKVQLLLHCRLEDPDRAGVLRSMLNHTYEYRSSQLFELLDTFMDPKWEDYLQLAAEGTGVGEEVVHFARVQTYKLYRLLQEHKNSISRDFLKNKLLRDFIDGQRHLYPDQFINRVQVFVKSVKKIVKANFSLEYFYRTSEVIEEARSLGCGIVVPHPEQFWPILLCDYDIDGYEVWNPQSREYTEFLVNVINRQNKSRSRSQRPLLVFMGDDAHMGEKIKDPTKIEAAKYYREIGVQPAWDDLTIKKSLIIGNFDRRKVMNEYKTRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMJ9</accession>
    <name>D6SMJ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869038.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35910">
        <property type="protein sequence ID" value="EFI35910"/>
        <property type="gene ID" value="Dthio_PD3350"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2123774at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17107" checksum="574CA1EDAE01C367" modified="2010-08-10" version="1">MTRDTFMHILMAGTKGDNKFWKAMGLLEELSAKRIAVTDKESLFQALSTIPGPVMVLVLSSCLSEKLTKEEILRIREDYEAEIIVAGKFSTWRDELSARTAGIACYILLPDEAPVLAEQTRHLLNTCRRRLDNQPGRLRGNNRTGRNVPFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMV9</accession>
    <name>D6SMV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869148.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3462"/>
    <dbReference type="EnsemblBacteria" id="EFI36020">
        <property type="protein sequence ID" value="EFI36020"/>
        <property type="gene ID" value="Dthio_PD3462"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RQK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2010192at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025529">
        <property type="entry name" value="DUF4416"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14385">
        <property type="entry name" value="DUF4416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="180" mass="21307" checksum="BD91AAD282BE3994" modified="2010-08-10" version="1">MSHPEIPGPGKLFLSILSSRWELFEEELLPALSLRFGRVDFESPYIPLTETDYYNQELGTPIFRRIYTFYPLVELNRLPEIKLVTNSLEQDWLRDDKRLFNLDPGLLTLERLVLATGKNFTHRIYLDQGIWADLTLIFTRGDWVDLPWTFPDYASEKIKTHLREIRTSYRKQLQKASQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMZ4</accession>
    <name>D6SMZ4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869183.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3499"/>
    <dbReference type="EnsemblBacteria" id="EFI36055">
        <property type="protein sequence ID" value="EFI36055"/>
        <property type="gene ID" value="Dthio_PD3499"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432299at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021301">
        <property type="entry name" value="DUF2779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11074">
        <property type="entry name" value="DUF2779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2779" evidence="1">
        <location>
            <begin position="293"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="485" mass="55120" checksum="58009FF365E2DBD8" modified="2010-08-10" version="1">MTHRLSKSKILSGIQCPKRLWLEIHRPDLIEYDPNTLARMQTGHKVGEIACQYLAPGGVYVGLENGFGHALKLTRDHLDFSDLPIYEATFVHDQVLIRSDIVVPTGTGLKVIEVKSSTSVKDYHIWDCAVQAWVMQGAGRPVQNIEVAVIDSSFVYPGKGDYQGLLKTENVTKTAFEMRTQVEDWVRQFLKTLQGSTPDIEMGEHCRSPFECPFMEFCLPADRPAYPLECLPRIKSQLLQDLKQEGFEDIRDIPDGRLANPTQERVRRVTQSGEEELLLEADCSHEKFSYPRYFLDFETAQFAVPVWKGTRPYQQLPFQWSCHVQDRPDNLRHMEFLDLSGEPPMRDFAESLVSSCQELGPIFVYGSFEKTVLHGLIQHMPDLAHSLQALSDRIVDLLPIIRQCYYHPEMRGSWSLKAVLPCIAPELDYTVLPGIQDGGQAQEAYAEAIHPDTTPERIEEIRKGLAAYCEMDTLALVKIVEKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNA3</accession>
    <name>D6SNA3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1580"/>
    <dbReference type="EnsemblBacteria" id="EFI34229">
        <property type="protein sequence ID" value="EFI34229"/>
        <property type="gene ID" value="Dthio_PD1580"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="391" mass="43703" checksum="29610078B69CFDFD" modified="2010-08-10" version="1">MPKIGVYMVHAADKTGEPRRLANLVKGLADMGVSVCPIVSTKGVWNLEFEESGAHCLKIPPGTIRENISLKKLKKNPLLLFRCTADLVRSNLFAYRIVRQEHLSAVILRAPKGPLYMGIGARAAGSKIICDLDYVATYRMPVRLLTAYAILLSRLVTAQYKKTRKDLGLLSRSILRKKSFASILPGIDSEPLRSYREKRDTGYRSQKNHLTILTAATIFPRKNQLTLVHAVQQAAAACPQYSLTLILCGRVKDRAYEKNIQDLIKKSPPNARCLLLGWRNDIGEIMSDVDIFALPSQDEGVPNSVQEAMYIGLPVLAAPVGGIPEIIKDGVNGWLVHDNNAYGWKKAIVKSISHQELIKQMSLKAQKDADAFFSHREWAKRYWKTVCELIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNC4</accession>
    <name>D6SNC4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 3</fullName>
            <shortName evidence="5">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfC</name>
        <name evidence="7" type="ORF">Dthio_PD1601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869578.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1601"/>
    <dbReference type="EnsemblBacteria" id="EFI34250">
        <property type="protein sequence ID" value="EFI34250"/>
        <property type="gene ID" value="Dthio_PD1601"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="164090at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="16"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="542" mass="61541" checksum="4BCB7673886DFC2A" modified="2010-08-10" version="1">MSQTTPSESQLAQEVRKRRTFGIISHPDAGKTTLTEKLLLFGGAIQMAGSIKAKKAQRHARSDWMEVEQKRGISVASSVMKFLYQDCEINLLDTPGHQDFSEDTYRVLTAVDSALMVIDSVKGVEEQTRKLMDVCRMRSTPIMTFVNKLDRDGRDPFELLDEIENTLGIQASPLTWPIGMGKLFQGVYDLVNQEIRFFTPPDDKGRRPEERAVIKDLDDSKLDELIGSAAAESLRQDLELIHGAGYPFDRDAYLEGRQTPVFFGSAVNNFGVRELLETFVKEAPPPRPRPASTREVSPLEQEFSGFVFKIQANMDPAHRDRIAFMRICSGRFQRGMKVRHHRIGKDIQLSNAIIFMAQDRAGVEEAWPGDIIGVHNHGILKIGDTLSSKEELQFLGIPNFAPEFFQRVFLKNPIKSKQLEKGLVQLTEEGAIQLFRPVGGNDYILGAIGSLQFDVTAARLKAEYGVDAAYEPLDYSTVRWIWARDKKALEKFRKRYFNSLVQDVEGYPAMLFATRWRLERTREEWPEIEFLASREQQEAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNE3</accession>
    <name>D6SNE3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylylsulfate reductase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869597.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1620"/>
    <dbReference type="EnsemblBacteria" id="EFI34269">
        <property type="protein sequence ID" value="EFI34269"/>
        <property type="gene ID" value="Dthio_PD1620"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011803">
        <property type="entry name" value="AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02061">
        <property type="entry name" value="aprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="667" mass="75574" checksum="7AD1F6CD2B0D9F58" modified="2010-08-10" version="1">MPVIPSKSQNLGVPIGEPEIKEIDVDCLLVGGGMGCCGAAVEIKKWADKHDVSYLMVDKASLERSGAVAQGLSAINTYLGDNTPEDYARMVQNDLMKAVREDLVFDLGRHVDDSVHLFEEWGLPIWVTTDDGKRLDGAAAKKKGLQVREGAKPVRSGRWQIMINGESYKVIVAEAAKNAIGEDKYMERIFVVKLLLDANEPNRIAGAVGFSTRENKVFVFKANAILVACGGAVNVYRPRSTGEGMGRAWYPVWNAGSTYTMCSEVGAEMTMMENRFTPARFKDGYGPVGAWFLLFKAKATNAQGEDYMVKNDHLIQPYRDKGYATGKVMPACLRNHCTLEEMRQGRGPIFMDTATALQDTFKELSKKEQKHLESEAWEDFLDMCVGQANLWACMNIEPENKGSEMMPTEPYLLGSHSGCCGIWVSGPDEDWVPEEYKVRAANGKAYNRMTTVMGLWTCADGVGASGHKFSSGAHAEGRIAAKQMVRWCVDHKDFKPTLQESPQDLAKMVYLPWYNYEEHKNVSTAPDINPKYITPRNFMMRLIKYSDEYGGGVATYYTTSEALLEVLSQHLDMLQEDSLKLCARDLHELLRAWENYHRLWTVRLHTMHIRFRKETRYPGFYYRSDFMGLNEEEWLCFTNSKYDPQKGEMTFFKRPYIQIFDPKWDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNL4</accession>
    <name>D6SNL4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869668.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1691"/>
    <dbReference type="EnsemblBacteria" id="EFI34340">
        <property type="protein sequence ID" value="EFI34340"/>
        <property type="gene ID" value="Dthio_PD1691"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2085787at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="88" mass="9675" checksum="E94C3C7FC0F80930" modified="2010-08-10" version="1">MIWSNQAVMGMELIFVCPEQKTAFTTSKWKVDGGLTAVSDSSGNRSLKGRIEAWCPFCLVEHTFSPDELPCPFKSTQDKQSTGGGDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNN0</accession>
    <name>D6SNN0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869684.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1707"/>
    <dbReference type="EnsemblBacteria" id="EFI34356">
        <property type="protein sequence ID" value="EFI34356"/>
        <property type="gene ID" value="Dthio_PD1707"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="77"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="219"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="308" mass="34605" checksum="89D68B22B0B0DEBF" modified="2010-08-10" version="1">MINKVSGKSLSILALVLFLFLAGGCLNKEPATQAGYQPGQPIPSVEVEVDVPNPFHTYVDAYFVKSIVCDNLIQEEPRDDVLLIDSRPKRPRYDRGHIPSAVSLPDSEFEEKADQVLPDDKSVLLFFHCQDTACRLSHDSAWKAEEMGYENVVVYPEGNADWEDRGFKTWTIDDITEPDEADVAAKERAEEPSEPSDIKEGDFPGSIEEEFFKEVLATDPDSIQLIDVREEDEFEKGHIPGAVRMNVAEIREAMDDFDTSEKPIVLICATGARSGEAYFTFDDLRPELDVYYLDASISYKDDGSYEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNP9</accession>
    <name>D6SNP9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869703.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1727"/>
    <dbReference type="EnsemblBacteria" id="EFI34375">
        <property type="protein sequence ID" value="EFI34375"/>
        <property type="gene ID" value="Dthio_PD1727"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="13125" checksum="8951341291EF05E2" modified="2010-08-10" version="1">MQPEDRIRLKHIIEEAKEACLYVQGLSFEDFLHDGKTVRAVIRSIEIIGEAASKISMELREDYPDIPWKKIIGMRNRLVHVYFDIDHEVIWRTVQVNLPPLISKLEQVINSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNR7</accession>
    <name>D6SNR7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, Csy3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869719.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1746"/>
    <dbReference type="EnsemblBacteria" id="EFI34393">
        <property type="protein sequence ID" value="EFI34393"/>
        <property type="gene ID" value="Dthio_PD1746"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7PG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1210545at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013399">
        <property type="entry name" value="CRISPR-assoc_prot_Csy3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09615">
        <property type="entry name" value="Cas_Csy3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02566">
        <property type="entry name" value="cas_Csy3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="354" mass="39332" checksum="E30D3E7018118F71" modified="2010-08-10" version="1">MSIGNLPKLLSFQRGVAVSDGLMYNYTSKPQNGYSKVRVVRHGIRGTQNVSDASKEKLYQVQVTESAKTEANAEGLVIRFSFGLLPLKNLLFSSSEKSFSDHCQAFAERFGGSEELMEISCRYARNVLNGRWFYRNSELESGRQITVKFLPPGSETKDLPEADGVTVQSATSLGFRNDYTADEKKLGAEICKCLKGESKTRFHVEGVIKFGMKGVFEVFPSQNYVSSKPKGFARPLYKVGVVDSRELSDILKDSDPSSFRADMISMGHAALRDQKIGNALRVIDTWYERGDDMTPIAVEPNGASLKDNHYYRKKNGSAFVLMKKIDEMQPGNGELNKDAMFLLATMIRGGVFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNW0</accession>
    <name>D6SNW0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869758.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1795"/>
    <dbReference type="EnsemblBacteria" id="EFI34436">
        <property type="protein sequence ID" value="EFI34436"/>
        <property type="gene ID" value="Dthio_PD1795"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1714999at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="377" mass="42548" checksum="812857A7A495A71B" modified="2010-08-10" version="1">MKIAAFFPVALLVGIIVFSLSIFTVDEREYALVLQFGEHKRTIKEPGLHFKIPLIQSATLIDKRVQTSDVGADEFLTVDMERLLIDHVTRWHVKDALLFYMTVRNVREAQGRIQNVVVAELRDVVSNQSILNVIAEEREALMTLVSERARERIEDFGIMVNDVRMKRVDFPSEVEENVFARMEAERERIAARHRAEGEEIAMEVRAQADADRERILGEGEALATETFAEGFTEDVLMVTDQEGNAVAGAFVSINGRDVGLTDAAGRITIAFPKVDEVRVRAQVEIEDQLRRGTLEGDLEDGYTMDVSRSGDLHLEFEGRPATYLGYLADEEFFRFQKSLSTYRRVMLPSSTTMVMSTDADLFDYLGGPGMPVEIDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPA4</accession>
    <name>D6SPA4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lpxD</name>
        <name evidence="7" type="ORF">Dthio_PD1952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869900.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1952"/>
    <dbReference type="EnsemblBacteria" id="EFI34580">
        <property type="protein sequence ID" value="EFI34580"/>
        <property type="gene ID" value="Dthio_PD1952"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1602061at2"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="6">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="343" mass="36911" checksum="A48EE20948C479F1" modified="2010-08-10" version="1">MLLSEIAARLKLEYTGEDLDITGVNTLEQAGPDELSFLSDSRYLPRLETTSAGAVIVPPEKAEMVSRAIKSPNPYLDFARVMQLFHEPQGMQESFPGQEGIHSTATIDPTAIIHPMVFIGANARIGPGCRIFPHCYIGENVVLGRDCLVYPQVSIMAGCRINDRVIIHPGAVIGSDGFGFIQDGEERVKIPQVGRVVIEDDVEIGSCTTIDRATLGETRIGKGTKIDNLVQIAHNVQTGENCVLISQVGISGSVRLGSNVILGGQVGVAGHLEIEDNCRVAAKSGVGKSLPANTDAGGIPAMDHTTFLRNAVLLPRLSQMNKRIKQLEKQIQSSNRPNQGEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPC6</accession>
    <name>D6SPC6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine synthetase, type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869922.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1974"/>
    <dbReference type="EnsemblBacteria" id="EFI34602">
        <property type="protein sequence ID" value="EFI34602"/>
        <property type="gene ID" value="Dthio_PD1974"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="110"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="447" mass="50610" checksum="90F08353E95E5F0B" modified="2010-08-10" version="1">MDVPVFNCKNPDDVIKAVKEYDVSFIQFWFVDVLGTLKSFQVTPSELDAAFDEGMGFDGSSIEGFSRIHESDMVAIPDPCTFQMVSWRPAEKPVARMFCDIKNPDLTPYEGDSRYVLKRVLKRAAEKGYDFFVGPELEFFLFEDSTAPKGIDVGGYFDAPPLDRANDIRRDIIFALNKMGIQVEYSHHEVAPSQHEIDLRYQEALKMADQAITYRVIVKEIARKHGCYATFMPKPLFGENGSGMHVHQSLFKNGKNAFYDPKGEFNLSSDGKSYIAGLLTHAKELTAVCNQWVNSYKRLVPGYEAPVYVAWARRNRSSLVRVPMYKPGKEEATRVELRSPDPACNLYLAFASMLAAGLEGMEAGYSLPAPVEEDIFEMNVQERAKHGIDSLPGSLHEAVNELSKSSVIREALGDHIFNKFVENKIIEWDNYRIQITEYELNKYLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPC8</accession>
    <name>D6SPC8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869924.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1976"/>
    <dbReference type="EnsemblBacteria" id="EFI34604">
        <property type="protein sequence ID" value="EFI34604"/>
        <property type="gene ID" value="Dthio_PD1976"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8W3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1250894at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011435">
        <property type="entry name" value="UmpAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07556">
        <property type="entry name" value="DUF1538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="243" mass="26204" checksum="4689A73660A813BF" modified="2010-08-10" version="1">MTSLILEFLDVSHVLVNVLMAVGPLLAFFIFFQFAYLQLDRQYVINLFKGVVLAIAGLTLFLQGVEVGFMPVGAEMGEIMNNFENLWILIPIGFVLGLVATIAEPAVRILCYNVERASAGSLGQMFMLITLSLGVGVFVAMGMGKIIFGFSIYYILLPGYILALLMMKLSEQSFISIAFDAGGVATGPMTVTFVMAIALGLAEAMEGRSAIHDGFGLIALVALAPILSVMTVGVFLNLKTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPL0</accession>
    <name>D6SPL0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870006.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2058"/>
    <dbReference type="EnsemblBacteria" id="EFI34686">
        <property type="protein sequence ID" value="EFI34686"/>
        <property type="gene ID" value="Dthio_PD2058"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1706506at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="PTHR31005"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088258" evidence="2">
        <location>
            <begin position="29"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4140" evidence="4">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="3">
        <location>
            <begin position="213"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="513" mass="58562" checksum="CE18B08E96012BCB" modified="2010-08-10" version="1">MSAKLKKFMLCLTALVGISLVASFKAQASPREVLIFPDSARVWDAGKFEVQEREGRTAVRLELPAQADPSTLLVRPEAPEDLSVADVQWSRTDPEDSRRVRELRQKLQEHESSRQKQEAVLKAYQARTAFWESRRDHHEEADRMDQAAAKIFEALKLAYLEKSEAGNELEEIEKRIQELQDRLREITGPEHKTWEVLVFLEGADSLEAAGIAFDYILSGCGWEPEYRLQADSAEGGVQFTWNARVWQSSGHDWQDTRISLATLEPQTDLDPPRIPDWIVRPIPEAGLPGPRDVRMSVMEAAADKAPVQERRGQFSVWHLGEQDLAAGERPRIKIHEETWPAEFVRLLRPSRSNNAFLRAQLDLDKVQNIPPGEAVFFHDQAMVGRRDFSFTGAEKEIYFGEDPFVTAETITKASASGTRGIIRERQTYRWHFLVNVHNHHDHPVRIRLEEPRPVLGDDNMQASFDLTPEPSEETESLFIWEMDLGGGEKGEVDLQMQIQAPGDMDVDWGWRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPQ1</accession>
    <name>D6SPQ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPW/gp25 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870045.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2100"/>
    <dbReference type="EnsemblBacteria" id="EFI34727">
        <property type="protein sequence ID" value="EFI34727"/>
        <property type="gene ID" value="Dthio_PD2100"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918415at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017737">
        <property type="entry name" value="TssE1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03357">
        <property type="entry name" value="VI_zyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="124" mass="14106" checksum="453804BCCB644131" modified="2010-08-10" version="1">MGLFDKFAVGSNEKKSEELQDILQNLNSILNTKKHYGAPLGDLGMDDMNYHSSRGLLASKMAEQIKENVERYEPRLRIVSVEPTESENPLHLSFVLVCELRDKSQKLKVVFDSFSSVYSMEHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPQ7</accession>
    <name>D6SPQ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2106"/>
    <dbReference type="EnsemblBacteria" id="EFI34733">
        <property type="protein sequence ID" value="EFI34733"/>
        <property type="gene ID" value="Dthio_PD2106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="113" mass="13038" checksum="7A9E36313EC716F8" modified="2010-08-10" version="1">MMALLTTKDCLNDVAAKVTFCSHIYYEEMWEKCIKNQYLFSAFKESRGQALRDPLEHHFVLKKTQFLGQVGPGRASPRATCKALNKYKNQDVAMYLQHGETVILLFFADKMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ53</accession>
    <name>D6SQ53_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870193.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2270"/>
    <dbReference type="EnsemblBacteria" id="EFI34879">
        <property type="protein sequence ID" value="EFI34879"/>
        <property type="gene ID" value="Dthio_PD2270"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014576">
        <property type="entry name" value="Pesterase_YhaO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033091">
        <property type="entry name" value="Pesterase_YhaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="423" mass="47008" checksum="6B8241364B5DFC52" modified="2010-08-10" version="1">MLTFIHAADIHLDSPLHGLSRYEGAPAREIRQATRKALDNLVNYVLEHRIPLLLIAGDLYDGDCPDFQTPLHFSAQMSRLREAGTRVALIRGNHDAQNRMTKSLRLPDNVFTFSAARPATWKLEDLGTAVHGQSYDREAVLENLALNYPDPVPGMFNIGLLHTSLSGTPEHSGYAPCTLNQLLAKGYDYWALGHIHRHEILHRDPPVIFSGCIQGRHIREPGGKGCMRVDVDPSGRINIERVELDVLRWQHMELDVSGLKTRGAVLDLVSRELENISAARDSEKLLGLRLTLKGTTGAFSDIMHDFAGLQAEIRNLATDISGQTIWVEKIFNQCTPALDWEEIKASGTALAHLAGYMQALEQDPELFKSLDLDLTELRAKLGGTGVELPDLDDPHTRQEYVSRCRDMVMTLLARDMSSTGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ57</accession>
    <name>D6SQ57_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malto-oligosyltrehalose synthase</fullName>
            <ecNumber evidence="2">5.4.99.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.15" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870197.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2274"/>
    <dbReference type="EnsemblBacteria" id="EFI34883">
        <property type="protein sequence ID" value="EFI34883"/>
        <property type="gene ID" value="Dthio_PD2274"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="217555at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047470">
        <property type="term" value="F:(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="17"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="891" mass="101169" checksum="32183F43D50550C7" modified="2010-08-10" version="1">MFPEPRATYRIQLHQDFDFFAAAEIISYLAELGISHIYCSPYLQAASGSTHGYDVVDPTRVNAGLGGESGHRAMLQALKQASLGQVLDLVPNHMAIPGRENPWWWDVLENGPSSPYASYFDVDWDSSEDRWPNRVLLPVLGDHYGRVLEAGELRLVQDQGEFTLKYHEHSFPVDPCSLSGLLARAAHNCGSDLLGFLAGCCSRLPRPTVTKRREVMRRHRDKAVIAGLLTGLCAEPGPRMAIEGEVDRVNQDPDALDRILDEQNYRLAWWRTAGRDLGYRRFFDINSLAGMRVENEDVFAATHSLPLKWVREGSVQGLRIDHPDGLRNPAGYFQRLRDTCPGVWIVAEKILEPGEQAPPDWPIEGTTGYDFLNLVTGLFVDQSKEDLLTDFYVSFCGNDQDFKALVRVCKEKVIRELLGSELNRLTSLFVAVCEKHRRHRDYTRHELQEALVRVGANYPVYRSYVRTGSGEKEPVVSQADKYYVREAIALAAEETPEPDAELLSFLEALLLLEIPGVLEGELAMRFQQFTAPVMAKGVEDTAFYRYSRLLCLNEVGGDPGHFGTSLEKFHRQAGTARDKRPLSLLAGSTHDTKRSEDVRARLCLVSEIPEKWRNQVQAWHEQNRKYITDGVPEPNTEYFIYQTLAGAWPISPERLEIYLEKALREAKEHTSWTSPDKDYERRMQEFARSVMQDERFCRGMQEFIEPLIPAGRVNSLAQTLIRMTFPGVPDIYQGCELWDMSLVDPDNRRPVDFQMRQMFLAELPGLQVQEIMERMNVGLPKMWLIRQALGLRRRRPHAFGPDGEYRPVYARGKKSDHVVAFLRGEIVLTVVPRLVLGLGGDFEDTVLDLPPGDWENVLTGERLAGGKIELSRLLDKFPVALCARDREVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ59</accession>
    <name>D6SQ59_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870199.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2276"/>
    <dbReference type="EnsemblBacteria" id="EFI34885">
        <property type="protein sequence ID" value="EFI34885"/>
        <property type="gene ID" value="Dthio_PD2276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="413" mass="46169" checksum="EB1CAE2809720A26" modified="2010-08-10" version="1">MSSLLDAYAKVAGQDVVSHLKQLAAPLRGMKVVHVNSTRKGGGVAEILEKLVPLSAELGLDVRWEVISGNEQFYQCTKAMHNALQGLAAPISRPLLDVYEQINLENAQELRAVLEEADFVFIHDPQPAPLLGLCPGRKGRWVWRCHIDASRPYRPVWRYLRDHVSGYDASVFSLPDFAQALPHPEYIIPPSIDPLSDKNIDLPQEEIEDVRKEFGLDPERSLVLQVSRFDRFKDPVGVVEAHRLARKFTPGLQLVLAGGTADDDPEGEAVLTEVRAAAGDDPDVKILLLPPDAHRKINALQRMADIVIQKSVKEGFGLTVTEGLWKGRPVIGGDTGGIRLQVINYHTGFLVRTPQGAALRIRYLLHRRDRMQEMGDKAREFVRENFLLTRHLREYLTLMVGLENGAGYRIELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ90</accession>
    <name>D6SQ90_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Colicin V production protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2307"/>
    <dbReference type="EnsemblBacteria" id="EFI34916">
        <property type="protein sequence ID" value="EFI34916"/>
        <property type="gene ID" value="Dthio_PD2307"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="186" mass="20849" checksum="B4349C48245BA764" modified="2010-08-10" version="1">MNALDIFFVVVLGFFLFRGIYRGLVLEVASIGGLIAGFLTANRFYMDVFPWVHEIINNETWAQIISYLSIFLISMAAVALLAFFLRSLLRMIMLGWLDRLGGGVLGFIKAGLICSISLLLLTVFLPAEHALVADSQIAPYLFELSESLAGYLPEDLKETFSDKAGKATEMWEHGWQELFNQEAEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQA6</accession>
    <name>D6SQA6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870246.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2324"/>
    <dbReference type="EnsemblBacteria" id="EFI34932">
        <property type="protein sequence ID" value="EFI34932"/>
        <property type="gene ID" value="Dthio_PD2324"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="32"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="383" mass="41481" checksum="98EE8E36CC694294" modified="2010-08-10" version="1">MNKLTYLTPEKGPLPEQVRRAMSRDVWGLREQEIKEACIRIEAGLKALLGTKEPVTVSFAGAAEVLRRTLQAQFEPGDEVLVVEAGMQGLQLSDAAQSCGLEVVALPIPWGRAVKPGEVENTLSRWPGIKAVLLPAVESSTGVLHPMQDIAGLCRSFEKMLVLDATGLIGSHLCMADAWSADCVLSASGPDIMAPPGAVFTAFSHRAREKMHKIFQGDKSLWLDPGKISPGEVFRHPLLHVLPALDEALGIYMHQGLDHASQHSKALCLMARAGVEAMGLELLVHREFARSLTSIRLPPGIDEKRLLQMARDDYSVVMSGGQGQLAGRTVRMGHAGCTSWKDVLAGLVALHQAFVDCGGVSGSRDYLERAWLAYTSSSEHKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQF9</accession>
    <name>D6SQF9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="9">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisS</name>
        <name evidence="11" type="ORF">Dthio_PD2377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870299.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2377"/>
    <dbReference type="EnsemblBacteria" id="EFI34985">
        <property type="protein sequence ID" value="EFI34985"/>
        <property type="gene ID" value="Dthio_PD2377"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="47333" checksum="1EFDCE9198319399" modified="2010-08-10" version="1">MSRVNKIKGFFDLFPPESTSYTFMEDKAREIFARYAYQELRTPILEQTELFARSIGQDTDVVQKEMYIFPDRRGRSLTMRPEATAGVIRAYIDSPAASSGNVSRFFTLGPMFRYERPQKGRTRQFHQVNAEMLGEDSPYADAEILSMLWGYLQSLGLKELVLEINSLGCPACRPGFDAKLKSFLEGINRDVFCEDCQRRAGSNPLRVLDCKAAGCREVASEAPRIVDNLCPECKEHFDRVLGILKSFDIYYELNPFLVRGLDYYQRTTFEVISNDIGSQSAVAGGGRYDGLVKVLGGPEVPGIGFACGMERLALLLQGIQERPMDFYMAVLHEDALDKAMLMVRRLRSKGYRGEMSFQVRSVKSHLRQANKKNVKTCLLLGLDEMHKNQVQVKDMSTGVQRAVSQDDAEQALGLVFQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQL8</accession>
    <name>D6SQL8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotase</fullName>
            <shortName evidence="6">DHOase</shortName>
            <ecNumber evidence="6">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrC</name>
        <name evidence="8" type="ORF">Dthio_PD2438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870358.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2438"/>
    <dbReference type="EnsemblBacteria" id="EFI35044">
        <property type="protein sequence ID" value="EFI35044"/>
        <property type="gene ID" value="Dthio_PD2438"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="52"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="426" mass="45917" checksum="635101EA0BF42782" modified="2010-08-10" version="1">MAYTRISNAVLNGTAGTLFLHEGLVQEFVPGGLKDPGSADKDRELDARGCHILPSLIDVHVHLRDPGLEYKEDISSGLSAAASGGFGRVLAMANTDPVNDNAGITGHMLQKAREHHPVGPFLHPVGALTRGLKGRDLAPLAELAQAGCRAFSNDGLPVQDNELFRRAVEYASDLDLKVIDHCEDSFLSSGGVMNEGRMSDYLGLKGIPDVAESLQVSRDILLAAYLNTPIHLAHISCASSVELIYQARQKSIPVSAETCPHYLHWSEELVSGYNTLARVNPPLRTRDDVLALRQAVRENIIDAVASDHAPHADFEKEVPFADAPNGISGLDTSLSLMLDLVRQGVLETQDLVRLMASNPGEIFRLPVCSFAPGDPADFILVDPEKQWVPGPETMLSKGRNTPCLGQTLQGRVMAHFLGGAAVINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQP3</accession>
    <name>D6SQP3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="8" type="ORF">Dthio_PD2463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870383.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2463"/>
    <dbReference type="EnsemblBacteria" id="EFI35069">
        <property type="protein sequence ID" value="EFI35069"/>
        <property type="gene ID" value="Dthio_PD2463"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1766414at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="130" mass="14705" checksum="2137373816FD91F0" modified="2010-08-10" version="1">MKEEYFYGKGKRKTSTARTRLYSGSGQILVNGRPYQEYFPRATLQMVINQPLKLTQATGKFDIKINVDGGGLAGQAEAVRHGISRALLQVDQDNRPVLKKAGLLTRDARVKERKKYGQRGARAKFQYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQP5</accession>
    <name>D6SQP5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2465"/>
    <dbReference type="EnsemblBacteria" id="EFI35071">
        <property type="protein sequence ID" value="EFI35071"/>
        <property type="gene ID" value="Dthio_PD2465"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="263" mass="29175" checksum="CEECCC5FD53B4147" modified="2010-08-10" version="1">MENEPSSEIARAALGVRNLHKSFGSLHVLKGVSLTAREGDVISMIGSSGSGKSTLLRCINLLEIPTSGDIFVGGEQIRMQVNRHGVPVPADRRQVDRIRTRLGMVFQHFNLWTHMSVLDNVMEAPVHVLRVPRKEARERGMAYLEKVGIADRSHYYPAQLSGGQQQRAAIARALAMEPRALLFDEPTSALDPELVGEVLSVLQELAREGRTMILATHEMSFARDVSSQVIFLDAGVIEEQGPPGEVFTCPRSERCKQFLSRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQQ0</accession>
    <name>D6SQQ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870390.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2470"/>
    <dbReference type="EnsemblBacteria" id="EFI35076">
        <property type="protein sequence ID" value="EFI35076"/>
        <property type="gene ID" value="Dthio_PD2470"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1251692at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="208"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="418" mass="48365" checksum="D637D1952AF157D7" modified="2010-08-10" version="1">MHEQYPSVRKGLLQLIFSGSFMKRWNDKLRPVELVEVDKQAHKMFVAYILYLLNSRDMPADDRLRLGEEVIQGGIYEYLYRLVITDIKPPIFYRIKSNPEHYQQLTEWVLEQLQPRVQPLGAHFWQGLCAYLQKPDDTGLAGKILSAAHIFASSWEFGLIKGVNPGDDELKDIEANFEELLKEHFDLTGMREIAGGSRNGLGGLVNLCGRLRFQKRWSQTPRIPETSVLGHMFIVACLAYFFSLSVGACSSRRQNNFYAGLIHDLPELLTRDIISPVKQSVQRIKDLIREYEQRELEQRVFSLLDEPGYSELTARLRYYLGDQDYSEFDNTVVDKGRVLSLDADELHQNYNRDEFDPRDGHLLKVCDNLAAFIEAYTATRNGITNEQLQQAQWKIRNRYQRENLLGRLHIGALLADFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQT3</accession>
    <name>D6SQT3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PBS lyase HEAT domain protein repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870423.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2503"/>
    <dbReference type="EnsemblBacteria" id="EFI35109">
        <property type="protein sequence ID" value="EFI35109"/>
        <property type="gene ID" value="Dthio_PD2503"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="772324at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="645" mass="71503" checksum="07848365A87206A8" modified="2010-08-10" version="1">MHQDQQEILRLLQSENQADQREGAFLARDIKLAAAVPHLVELLQSRSIGVQEASDMALRKIGGAGSVNALIPLLSSDSPPVRNLAMDILRHIGHQDMDALLGLLKNEDPDLRIFAADILGSTRSYLAVSPLCELLLKDPEVNVRYQAAVSLGDLGRSGATECLNRAFMDEEWVQYAVVEALSKLRDESSVKVLIQALGNSSELVCSMIVDALGEMGNIKSVPMLLKRMEDSPAALRNKIVKAVIKILGGKALTFLSNKEKEKLHEYLLAAVNDDETDIQDAAILGLGYVGQERATRKILERATRMDPEHEEDRLNRAQQSLVSIGCNESLVEGLFSDDETLSLLAVKALGSIGGNEAVTNLMSAFPRKHRDLQREIAWVLHDCAGWEARDFFVQILREHQDGDVLKAGLGFIGNRLQDEDSVFVLMGFLEHPWDDVKETALEAVLSIGGDKVLEHFQNMLTSREIIHRVMAVYAMGKLGAASSLESLSRALGDEAYEVRKIALEALGHICPEDRNVLPLVVQALQDENREVRRGVVELLDECPHPDTHFYLLKALEDPDEWVRVRVIEALGRNRVKEHIPEMLSIWERSSQLVKIKIVEALGSIGGQTAFRSLLDILDYGDPEIQDAAERALDKLQEQGTEQGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR14</accession>
    <name>D6SR14_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870502.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33130">
        <property type="protein sequence ID" value="EFI33130"/>
        <property type="gene ID" value="Dthio_PD0448"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZUGW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2177742at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="13426" checksum="063C4F103D3F6F66" modified="2010-08-10" version="1">MSIAVVDSLPHDKGTLFTFEKNDAKYKIIFTTHALTRMEKWQLTLEAVSKTLLDPEEVLVGHNNRFIAHRCFGQHVLRAVYEYDDLVSVLITVYCPYKDRYFQGGGSFEDQILPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR15</accession>
    <name>D6SR15_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33131">
        <property type="protein sequence ID" value="EFI33131"/>
        <property type="gene ID" value="Dthio_PD0449"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8344" checksum="7B9D6357D009ED18" modified="2010-08-10" version="1">MKIKYSQETDILVVEFKEGVPVDSIDMKEGVILHLDSEGVPVEMEILDASKFVAMDEFNILVPMIKDKKIPVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR26</accession>
    <name>D6SR26_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870510.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0462"/>
    <dbReference type="EnsemblBacteria" id="EFI33142">
        <property type="protein sequence ID" value="EFI33142"/>
        <property type="gene ID" value="Dthio_PD0462"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925819at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="8071" checksum="C5A2EC058883EAB1" modified="2010-08-10" version="1">MKLNYYDETDSLYIEFSDETSAESVEISEGVVLDYDAQGKLVGIDIDNAGHKIQLRDFYLKGLHPNIMTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR37</accession>
    <name>D6SR37_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870516.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0476"/>
    <dbReference type="EnsemblBacteria" id="EFI33153">
        <property type="protein sequence ID" value="EFI33153"/>
        <property type="gene ID" value="Dthio_PD0476"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZGFC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2077740at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="7835" checksum="45A235DB7362BF97" modified="2010-08-10" version="1">MHVFADGISKVTLSNGNLRIMLTQSGADDSTVEAGTMIIPASQASNFLNGLANSLKELESRLKEAREAQQTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR63</accession>
    <name>D6SR63_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0503"/>
    <dbReference type="EnsemblBacteria" id="EFI33179">
        <property type="protein sequence ID" value="EFI33179"/>
        <property type="gene ID" value="Dthio_PD0503"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="9"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="351" mass="41180" checksum="F21EA1874BD086CC" modified="2010-08-10" version="1">MATKRNQAPHEGLFLKIFQNLDNARHFLKNHMSEEIQKRFDLDTLRLEPTTYVDEKLKKHYSDLVFSVRLIGYKNQFAKIYLLFEHKSSPDPLTGVQVLKYMALQWLDLQEQHMLVDGKLPPIIPIVIYQGQEDDRNMCSSFHYLVEMPSESFKVYIPDFSFAFFNVRGMDEAKVQEKILLKFYVEIIKYQNDPSVKEIPPRLVRGLIESLGHRTALEYIDIFFRYLVKSTGFLTQEDYKKALELLPEGGEAIMETLADQWMEQGAQKERHRAEEWIKQEKDKWERQAELKATQETLIDAATEQYGPLSGMLHEKIKSIQSLENLRALNRKVIKTQSLEEFTELVNRAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR85</accession>
    <name>D6SR85_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar P-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Basal body P-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flgI</name>
        <name evidence="5" type="ORF">Dthio_PD0527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FlgI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870559.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0527"/>
    <dbReference type="EnsemblBacteria" id="EFI33201">
        <property type="protein sequence ID" value="EFI33201"/>
        <property type="gene ID" value="Dthio_PD0527"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="693640at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009428">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, P ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00416">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001782">
        <property type="entry name" value="Flag_FlgI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30381">
        <property type="entry name" value="PTHR30381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02119">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01010">
        <property type="entry name" value="FLGPRINGFLGI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="370" mass="38895" checksum="CC5F11DC9A4B79C2" modified="2010-08-10" version="1">MIIPGKAKAVFLAVVAVFVLGIWDSAQAVRLKDVATFSGVRENQLVGYGLVVGLDGSGDSQASPFTLRSMSNMLEGMGVSVNPADLQPDNVAAVMVTANMPSSARPGSKMDVTVSSMGDADSLMGGVLIQTPLSGIDGNTYALAQGQLTVGGYSVEGDAAEITTGVPTGARIPGGATVEREVPYRFNTQDDIVVNLNMQDFSTTSQVTESINEHFGQNLAHAKDNSTIRVDIPDGFQGNLVPFMAALENLQVSPDSPARVVVDEKTGTVVIGENVRLSKVAVSHGSLTVMVREMPDVFMPLPFTDAPPVIAPETEIDIVEEEQHLTIIEGATINELVEGLNAIGATPRDLISILRTLKASGALHAELEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR98</accession>
    <name>D6SR98_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870572.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0540"/>
    <dbReference type="EnsemblBacteria" id="EFI33214">
        <property type="protein sequence ID" value="EFI33214"/>
        <property type="gene ID" value="Dthio_PD0540"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1455964at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="1">
        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="274" mass="30974" checksum="16F907CF4E9ECA42" modified="2010-08-10" version="1">MALSNLAQILSLSPNVQMDMLMSAYFRDSQVGANLRRMMIGEQPIQPLTSPFDQAITGRLRSDSAAIRQHSRNVQEAAQIMGIASEAVDSIRDTLKQMQDLAQKIDEGDLEYRQEVADDYNEMREKIESIISHTQYNTMHLLDSEKWGGSSLIDEDGKVQIKSLLGRDGLTTIKFYPLDDRDWKGLEGTDLETEADREGQLDLLSELIGDVTTIEDIYSGRKSSLEFQASRLESQADIMDEAVEARKQTPEMSLEEILVNLLLRYSGRIFDQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRD4</accession>
    <name>D6SRD4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PpiC-type peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870608.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0576"/>
    <dbReference type="EnsemblBacteria" id="EFI33250">
        <property type="protein sequence ID" value="EFI33250"/>
        <property type="gene ID" value="Dthio_PD0576"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1201303at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="264"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="628" mass="72375" checksum="BBD978C6419FD81F" modified="2010-08-10" version="1">MLDIMRRNAQSWIVKVLFGVIVIVFVFWGVGSFTEDDRETLAVINGEPISIQEFARAYESTAHSMREQNPGLSREDMRSMQLREQVFNQMVNSKLLVQKASQLGLSVSREQLQQEITSLPAFFDEENRFDPQRYEQVLRSHRLTPSQFERDFRHNLLMEKMEEYVSLPAKPNEHEVQEFFNYVRSQAKIDYKLFEADEFHDKVSITEEQIKEYYQDNQDRFMEPEKIRIAHLELSPDALAGAQRVSSEEVEAYFQSHQSEFEQPEEVKARHILVEVEEDAPELEQEQARERIEQILAELEMGQSFEELAREHSQCPSAAEGGDLGRFGRGEMVEPFEEAAFDLTPGEVSSPVQTRFGWHLIKVEEYVEAASPDLEEVEDEIRRKIGREKAADQIGDYADDVLEIVVAGGSLKEAADSLGLELKETDYFSREQGPEELELPGEALDRLFNLMEGEVTESPIMLDNGYLYAEKTGVREARSLELEKVEDEIVEELTRQKSMEMAEKAAGDKLDKILDEAVEPEELDLVTSEPFDRQGFIPGLGMNPQLAEQAFVQDTGSWLPEVKSTDAGYIVARVNEHIEPDMEQFEQEKDQWMQSYAQMQRQQVFNSYITMLRSRADINMVRPEVLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRF8</accession>
    <name>D6SRF8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0600"/>
    <dbReference type="EnsemblBacteria" id="EFI33274">
        <property type="protein sequence ID" value="EFI33274"/>
        <property type="gene ID" value="Dthio_PD0600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="10602" checksum="70D27D208965C71B" modified="2010-08-10" version="1">MPKSAWGQSPRHLAFTITKITSSKFRDPAQTYTGEGQSPDLGAIINTEDPLNGYVVIIFLLASVQRISYMMSAGYDVLGNLCYEKNPRSLFQAGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRG3</accession>
    <name>D6SRG3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein HSR1-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870637.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0605"/>
    <dbReference type="EnsemblBacteria" id="EFI33279">
        <property type="protein sequence ID" value="EFI33279"/>
        <property type="gene ID" value="Dthio_PD0605"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="2">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="598" mass="65153" checksum="2161C1496683E9F4" modified="2010-08-10" version="1">MSKAHVLLMGPPNVGKSVIFNHLTGLSVSCANYAGTTVEFVAGKAGINDRDVVLVDVPGTYTLNATNQAEQVAVDMLRGQHKPGTQSTCSHCREESDVCAEDLGSAPSAVICVVDANNLESSLYLLFQVLSFGLPTVVALNRVDLARDKNIHIDWEGLSRRLGVPIVPMVAVEKQGFQELKNEIRNSLDRPFEPRLDWSQDKHWSIAEKLSREVTTGRPSQNSSRRRRWGEKLVQPWPGLPLAIIILAIAFALIIGIGMQLRQLILLPFFRDLVIPQIVAVVQAFVPPGTIQNIMVGEYGFLVKGIEWPFALVMPYVLSFYGVMAALEDSGYLPRLGVLLDGLLNRIGLQGSSIIPLLLGYGCGIPGILATRALATGKERLIIATMICMAVPCISQTGAFIAMLAERSVSVVVAVFGLSFLALILAGLIMDKALKGPRPLTIMEIPELLPPRRDVLAKKIWIRFKRYVTDGALPMVVAVGIASVLYETGIMAAAGRFMSPLVEHWLLLPQEASVPLILGIMRRELAVLPLIEMDLTTLQLFVGATVGLFYVPCIAIVAILAREFSIKTAFFMLIATSATAFIVGGIFARMEFLAWIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRK7</accession>
    <name>D6SRK7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870681.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0650"/>
    <dbReference type="EnsemblBacteria" id="EFI33323">
        <property type="protein sequence ID" value="EFI33323"/>
        <property type="gene ID" value="Dthio_PD0650"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="53"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="228"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="448" mass="50993" checksum="7A8A9DD90B80BC32" modified="2010-08-10" version="1">MDSHLVQRILFLNPWLRDEVTPSQFVALHIPENYVQRSLAQSRLEEPMLGKPKVRLLIGPRQAGKSTLAWRMFQKSGRHPLFLLCEDMLIRSWCKEAVPFLRDLKELVPGPVPLFFEEAQHLPEAGLFLKGLVDLGYAEEILVTGSSSFHLMARTRESLAGRSIRHRLLPFSLEETAAPSKTLPPALVMDKRRGQLARHLTFGGYPEVWFSSAPEAVLWELIEAFILRDASDMFQVRYPDAFRRLLKLLAFDVGNLLNMSNLAQDCGVNRKTVQNYLDILEETHIVRRILPFKEGKRSEVTRNPKCYFVDNGIRNVLLGQVSEPDILERPDTGALVENWLLSELLKNLPIRWSVQYWRSTSKAEVDFVLSDGHQVIAVEVKAGRMSRPAVSRSARSFLDAYEPSVLFVVNLTLDTTVMVQDRPVRFVPLESAIPAILEHGKIMTSSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRQ0</accession>
    <name>D6SRQ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II and III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial secretin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870724.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0694"/>
    <dbReference type="EnsemblBacteria" id="EFI33366">
        <property type="protein sequence ID" value="EFI33366"/>
        <property type="gene ID" value="Dthio_PD0694"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="8">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="7">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="504" mass="57230" checksum="9997E17851CBDDC3" modified="2010-08-10" version="1">MRHIYIILTRHEKKVFALTAASSRTYSVCTLLILFILAAAIAGCTGTRDQEEPFMTQWWDLAEESRGHTHEVEERESLDIEPSHIDLEDIEPEPAHELPRDRVTLNMQQAPVATILRALSRIADQNIIVSETVEGTANLNIRDVPWDQAFKSIIASQGLSYVWEGEILRIKSMQDLQHELDRAGLKEDIGRRKLAAELTAPLMHRIVKLNYADPEKLQDNLIRFLSRDGDGEPHGSIVVDEETNSLMIQATRNDMERVHKAINHLDRPRPQILMEANIVEATQRTARELGVRWSGRYVTPLSFEDEVGFGDLLRDEAGYTGDMDLSVISARLPGSVLYAHLQALERDGEVNILTSPSITTMDNQMAFTEHGQRVPYETVDEDGSRTVEFEDAVLRLEVVPSVMEGNHLKMDIRVNKDEVDFTRDVRGQPVIRTKHTETNLVVRDGETIVISGLSKETLSDTERGVMGLRDLPGLGWLFKSREQEQEMEEFLIFITPTILEPQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRS7</accession>
    <name>D6SRS7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870750.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0724"/>
    <dbReference type="EnsemblBacteria" id="EFI33393">
        <property type="protein sequence ID" value="EFI33393"/>
        <property type="gene ID" value="Dthio_PD0724"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="36039" checksum="A58C5E6156C98D33" modified="2010-08-10" version="1">MPRNARFTLPHRPTVYHVISRTALSGLPLGDIEKNRLLEIIKYFSSIYFVDVLGFCIMGNHWHLAVKIYPRDYATRQEVQERFVKRYGEDVHFGDQEIEKFSKKWTDLSEFVREIKQTFSRYYNKRHNRRGFFWGERFKSMIVQEGSTLVNMLAYIDLNPIRAGIVKKPEDYRWSSLGYHVQTGNKDGFLSIDFGLKEWNEFDPQEIVRKYRQFVYETGAVDAGKGKTIDQKIVEKARKKGYKISRVERFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDKRKFTPVGGVEGVYSMKRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRT1</accession>
    <name>D6SRT1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">Dthio_PD0728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870754.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0728"/>
    <dbReference type="EnsemblBacteria" id="EFI33397">
        <property type="protein sequence ID" value="EFI33397"/>
        <property type="gene ID" value="Dthio_PD0728"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039018">
        <property type="entry name" value="VapC20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42188">
        <property type="entry name" value="PTHR42188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15440" checksum="B3B39F38FA11F9C4" modified="2010-08-10" version="1">MIFVDTGPLLARYLLKDQFHQHALNIWAELEKSHERLATSSLVLNETATLLGRRAGNIFAAERLNNIYASHAFQIWRPDREDELRALKLFAKFSDQVVSFTDCVSFTLMTSRHVQQVFTFDRHFDLAGFKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRY2</accession>
    <name>D6SRY2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870800.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0782"/>
    <dbReference type="EnsemblBacteria" id="EFI33448">
        <property type="protein sequence ID" value="EFI33448"/>
        <property type="gene ID" value="Dthio_PD0782"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="255" mass="28001" checksum="8820E2AAF13AD921" modified="2010-08-10" version="1">MSMQAVFCGVGEAFDENLPNTSILVQVKEDKNSRSALLDCGFTAASAFWGCSDDPLDLDAIWISHLHGDHFLGLPQLLLRFSEHARIKPLQISGVCGASSAVKQAMELAYPGKWDRLGFEIEFTEASSRDTFQLAGMQARAVPMEHPVPSLGIKLHAENRSLFYTGDGRLEKSFWPVLDGCDLAICEAFALEGDMPGHSSVSRVLSMAGLAGVRQTALVHMQRDERATHKDSLQKYFDQAQVTGFMPEPGDRVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSG9</accession>
    <name>D6SSG9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0970"/>
    <dbReference type="EnsemblBacteria" id="EFI33635">
        <property type="protein sequence ID" value="EFI33635"/>
        <property type="gene ID" value="Dthio_PD0970"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="388" mass="44235" checksum="CE5CC5A4672A8B11" modified="2010-08-10" version="1">MRHSMQKTLMIIDDYPENLKVLQEMLEVSGYRVVAFPSGPLALKAADKNPPDLILLDIKMPEMDGFEVCRRLKAHDKLKEIPVIFISALDQVQDKIRAFSQGGADYITKPFHPEEVHARVTSHLASKSLQDLLYSHSLQLEETVRERTRELIAANKQLQNMQRLKNSFLRMLSHELRTPVNGLLGISQVLLDICPMDNDLQQLRENFFLSRKRLNNLIEDASTIAGMDSFARDGYQRVSIWEYLDAARNCLQKVSVTVDREELLKQIYTSQDMTLFNRTMETILRLGLCFSSNRSLLQLFTEVDGQNLALKIHLDNLELTARETETFFHMDSEVRGYSAAQDLALAPVVAHEFLLASGGGLRLFKEENRTGWLEASIKIETGKNKIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSJ1</accession>
    <name>D6SSJ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871006.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0993"/>
    <dbReference type="EnsemblBacteria" id="EFI33657">
        <property type="protein sequence ID" value="EFI33657"/>
        <property type="gene ID" value="Dthio_PD0993"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="115" mass="13261" checksum="B18061765BD4EAE0" modified="2010-08-10" version="1">MEGTVRLFKALGDTTRLRLLSLLLQGEQCVCDLMFALQLPQSTVSRHLAYLKNSGWVKDCRRGVWSYYRIVGSSRPAHSQLLEILKTHLSGMEEIQEDLERLNQRLQIRKSDRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSK6</accession>
    <name>D6SSK6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871021.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1008"/>
    <dbReference type="EnsemblBacteria" id="EFI33672">
        <property type="protein sequence ID" value="EFI33672"/>
        <property type="gene ID" value="Dthio_PD1008"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SEM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1569029at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="123" mass="14729" checksum="A75AC0AF7C53705E" modified="2010-08-10" version="1">MYDANKIIPGLIIFALFMTFPFWYNLGADAYSTPELELPEDYEKCIESTEFMRAEHMNMLDEWRDLYVRDGYQEYWSELKQESYPMSLTKTCMDCHSDKEKFCDRCHDATAVDPYCWDCHIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSL4</accession>
    <name>D6SSL4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871029.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1016"/>
    <dbReference type="EnsemblBacteria" id="EFI33680">
        <property type="protein sequence ID" value="EFI33680"/>
        <property type="gene ID" value="Dthio_PD1016"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="162"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="293" mass="32801" checksum="C95E781243405919" modified="2010-08-10" version="1">MQKLNKHFLLAVSDDASLQYGARFLGYFFHNKGEIRVDMLNIAYNPQKTMAEPGDPTPHQTTQMQHASLEKGKLALQSAREKLEGYGFAEDSLKTDLKMQTFSTVHDLVSYGRKGLYDSLVLGHRGIGMLESLVQDSISSKLLHQECEMPLWICREPVRAKKDILICTDGSEASLGAADHAGFILAGEPEHDITVLHVAGSGSQADREKIINSTVDRLLDNNIDQKRITAKSLDRTDTARTILDYARENSFAVIAMGRTERHKSPGRLGRFFMGSVSEKVFKNFRQASLWIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSL7</accession>
    <name>D6SSL7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871032.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1021"/>
    <dbReference type="EnsemblBacteria" id="EFI33683">
        <property type="protein sequence ID" value="EFI33683"/>
        <property type="gene ID" value="Dthio_PD1021"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="280" mass="31164" checksum="301E5753A31DC42C" modified="2010-08-10" version="1">MNNLINRRIFLKQGVAATGGLLLAKGAAGTSQASSTQAAFLYDSIKCINCGICERTCERVNGLPEEHNVIRMSQKAAPGTPIHITRRHSCMQCIRPSCARACPTGATYKDEFGLVSFDSEKCMACGYCVDACPFQHPELSRFTYFSLRNVWINRCTACGACAQACPENALFFGFRNELMDMAKKRLDEIKNNYPLTKAQLYGEEDLNLIWILADDPYVYDLPGPTAAAVVDDKLMLWKDVLRPGILSLSGVAMAILGVVYFFARRNHKKEVERLRQEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSM9</accession>
    <name>D6SSM9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphonate ABC transporter, periplasmic phosphonate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate/phosphite/phosphonate binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871044.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1034"/>
    <dbReference type="EnsemblBacteria" id="EFI33695">
        <property type="protein sequence ID" value="EFI33695"/>
        <property type="gene ID" value="Dthio_PD1034"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="988224at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088189" evidence="3">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="36498" checksum="4EDE2E1965802722" modified="2010-08-10" version="1">MGYTIRRVFFCVALLSLMTLWGCGSNDDEYVTVDFSDTVEVDEEQPGYSDRPRLKAAVGAMISPRETFESYREILVYLSREMDMDLEFVQRKTYEEVNELLGKNEIDLAFICSGPFVRGREKHGFNLLAAPVVDGSRHYYSYLIVHENSPYESLEDLQGKTFAFTDPDSNTGRMVPLYWLHEMGFEPEEYFEDIIYTYSHDNSILAVSKNLVDGAAVDHLIWDYFHKSGSEITENTRIIKKSRPFGIPPIVASPGISQDKAQRLKEVLLSMHQDDKGKEILSSLMIEKFVAAEDHWYDSIRDIYKTLKTCEDQDAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSP3</accession>
    <name>D6SSP3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871058.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1048"/>
    <dbReference type="EnsemblBacteria" id="EFI33709">
        <property type="protein sequence ID" value="EFI33709"/>
        <property type="gene ID" value="Dthio_PD1048"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="117" mass="13592" checksum="1AB10F4B23B1C34A" modified="2010-08-10" version="1">MDKFLKQTKALADGNRLRIIAALLRQPELCVCQITELLGLSTATVSRHISVIQNAGLVTSRKDSRWVYYRLADDFPGRLRQWLEEELMYSREMEKDKLTLKFILSMSVEELCSKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSR8</accession>
    <name>D6SSR8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD1073</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871083.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1073"/>
    <dbReference type="EnsemblBacteria" id="EFI33734">
        <property type="protein sequence ID" value="EFI33734"/>
        <property type="gene ID" value="Dthio_PD1073"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="267"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="336"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="445"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="529"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="774"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="12">
        <location>
            <begin position="943"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="823"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1033" mass="116194" checksum="EEB92476AA6078A4" modified="2010-08-10" version="1">MKDRNKPEDELRRSEASQRILLDNIATQVWYLVNEYTYGAVNKAHADFLGMQVQEVSYASLYDLFPVDVVEVCRPGNREVFETGESLQTEEWVPDASGELRLLSIKKSPGLDRDGRVKYVVCSADDITDQRRLQDSLAESEDKFRLLAENAPMGIALHELVLDKHGNPVDYRYLDVNQGFERHTGLKASQVTGRTAGQVFGRQQDPPFLDTYARVVLGGRSVSFEEEVESLGRSFLINAYKVGLNRFATVFMDVSQRRQATREAEVRRSHFESIFENTKDAMVFFDTSHLIFNINSRFTAMFGYTLEEIRGKQVNRVVDPERLADDYISSSVLEGENVEKETVRYCRDGQPLDVLIKGGPVYVAGEIVGGYSIYSDISGRKQAERELTKQNQLLEGIINGIPDILAIQYPDHSIKRYNQAGYQALNKSPEQVAGRKCFELIGRDRECEVCATREALNTGTLQQVEKYVPELDVYMDCRSNPIFNEQGEILYIIEQLRDITQRKKDEIELIVAKEQAEAASKAKSEFLANMSHEIRTPMAGIMGALEMVSARTDDEESRRLMKMTLESARSLQQIINDILDLSKVEAGKLEIEHQEFDPQSLFKRVMDLYSIQAGEKNIELQLDTAPGIPRRLCGDQYRLEQVLRNLVSNAVKFTSQGRVILRVRPVQAASGKARLNFEVEDTGVGIKEDFLPRLFDSFTQADSTYGKKHQGTGLGLAISNRLVQMMGGDIQAQSIPGAGSIFSFSLPFAIPAEHTAGEKRSDTQSAVSFSRQLKILVAEDVKLNQDYIRFVLKQKGHQAVIAGNGLEAVQAFVPGQFDLVLMDIQMPDIDGLETARRIREKEESSGRTSDVGPRDSGRVPIIALTAYAMPEERQEFLQSGMDGYVSKPVDPEDLFREIESLVSVRDESGREAQSYQVQEQDFACSGAEVISTKDLELRFAGDRELWAGMFQRFMQEEMPGYMQELEDQSGSGDMQGLARLAHKFKGALGTLCAEAARQRAEALDHAARKSDTEMVRLELEALKAELERLKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSX5</accession>
    <name>D6SSX5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871140.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1130"/>
    <dbReference type="EnsemblBacteria" id="EFI33791">
        <property type="protein sequence ID" value="EFI33791"/>
        <property type="gene ID" value="Dthio_PD1130"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="242"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="845" mass="96469" checksum="F2327609DBFDAB89" modified="2010-08-10" version="1">MKELLPFLPRPSHYLGQEVNSVHKNRRSASVHMGLAFPDVYEVGMSYLGQKILYHRINDQDEYYAERVFSPSLEAAGIMREQNTPLCTLESDTPLGELDILAFSLTHELCYTNILYMLDLAGLPFKAHERSGAHPLVIAGGGATFNAEPVADYFDLMVLGDGEEVILDLLQKVKIARQQGMSRQDLLQTLKKLPGVYVPGFFKGPGLPLTPLREDYRQVTKSLVTDLNQVPFPTRQIVPYGKVIHDRLSIEIARGCTRGCRFCQAGSIYRPVRERSISRILEDVQQGLLATGLEELSFLSLSSGDFSALEELFTRSFARCQQQQVAMALPSLRVGSVNERLMQLMSRIRRTQATLAPEAGTSRLRQVINKGITEEQLLKHTGHLFDLGWKGVKLYFMVGLPTEADDDLKGIRDLCQKVLETGRSRKIKPQVTASVAPFVPKPHTPFQWERQAGLSEIREKIFRLKDLFKTSRTLNLKWHDPEMSLLEGIFSRGGRELSQVVAGAYARGETFTSWSDCFRLEPWLDIMDKSGLSPDTYLRARDTDEPLPWDHLQSGMERRYLLTEARRGRQARTSKDCRYHACRMCGVCDKKSRPSSLRKVSQTPSISNVLNRDFRDQEHDTEDIDSNLLEQKDLSPKTAHLRIWYKKTGLCIYLSQLELQSLLERAMRRAGWPLSFSTGFRPAPVIAFGRALPVGVSSLEEWYNIYLRKHLDSSHLLNSLNNELPRGMHAFALEHLSQGRRQPQSIQEEFQVELDLSGEDLQKAMTTWENYRSAPEFLVQKQTKKGLSTKDLCSYHKHSHWEKSSLKVVFTWEKDYLSPLFILQSIFSDLGREKMHITKTRQIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6STD5</accession>
    <name>D6STD5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1290"/>
    <dbReference type="EnsemblBacteria" id="EFI33951">
        <property type="protein sequence ID" value="EFI33951"/>
        <property type="gene ID" value="Dthio_PD1290"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1240854at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14727">
        <property type="entry name" value="ChanN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007314">
        <property type="entry name" value="Cofac_haem-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04187">
        <property type="entry name" value="Cofac_haem_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087956" description="PDZ domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="297"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="383" mass="43380" checksum="4D5A589B5985AA0C" modified="2010-08-10" version="1">MGIARLFFLCLALLMVAACAPKMPVHIEEPAPQPGEFYTGDGERLTSKEMVDRIRDNDFILLGESHNNPCDHKVQARIVHLLAQSGVDHVLGLEMVNVRRQEVLDSFNRGEISLEELPDRLDWSETWGYDFDLYRPVFEAAREHGVPVKALNLPSEVTRSISHYGLDSLDEEDRRYLPDKITMPPEEQLSFLEKQYEMHQEFVPEDRSELQHFIQAQSTWDSKMAEMAEQFGFEHSLPVVVLAGSEHVRMGWGIEHRLLKQDGDARVTRVLPVRDVEDISPDNPLYFYCPPAQAQHGRMRLGLIMSRQDDVLVVHGVVEDSAADRAGFQKGDEIIGVNSRAVHGMSDLHDAAVKASKTGEPVVFKVLRKAGIKSLKLELPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STG7</accession>
    <name>D6STG7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1322"/>
    <dbReference type="EnsemblBacteria" id="EFI33983">
        <property type="protein sequence ID" value="EFI33983"/>
        <property type="gene ID" value="Dthio_PD1322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="8525" checksum="1352F08DD6A9F682" modified="2010-08-10" version="1">MGLRYSGIGESRNWGIWGEGGVTPHQYVTIQGVPAIPTGNRLEAYSPAVSGRAARLSRETPSTHFNNFGFITSKQMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6STI6</accession>
    <name>D6STI6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 14">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 14">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="17" type="ORF">Dthio_PD1341</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 14">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 14">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 14"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1341"/>
    <dbReference type="EnsemblBacteria" id="EFI34002">
        <property type="protein sequence ID" value="EFI34002"/>
        <property type="gene ID" value="Dthio_PD1341"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18085">
        <property type="entry name" value="TM1570-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019230">
        <property type="entry name" value="RNA_MeTrfase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09936">
        <property type="entry name" value="Methyltrn_RNA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="15">
        <location>
            <begin position="44"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltrn_RNA_4" evidence="16">
        <location>
            <begin position="266"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI34002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="447" mass="49083" checksum="6F5381319E819F7E" modified="2010-08-10" version="1">MSLRPRWLQGSRQGVYFNPGTSVHFHIITLFPEYFDSPLSCGLMGKALEKDVLEVSRINPREFTRDRHRTVDDRPYGGGPGMVMLLDPLVQALNAMPPGCRKVLLTPKGKPLDQSLAASLAKENDLALVCGRYEGIDARLEELFDLDLVSAGDFVLNGGEAAALCLMESVARFLPGFLGKQESAGEESFSSGLLEYPHYTRPEEYAGLKVPEVLLSGDHGRIAAWRWQKALENTFRQRPELLTTRPLTSNDLDFLHGLQKTRPARNLYLALVHHPVKNKMGQESTTSLTNLDIHDIGRVCATYGLGGYYLCTPLKDQQVLARRLLSHWREGPGARANPDRALALAGVNVVSSLQDAVENVESLAGRRPRIVATSASGAGDIDCGQVFERLEKEPVLMVLGTGYGLSDRVVQEADNLLTPLRLLGGYNHLSVRSAASTIVDRILGDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6STK9</accession>
    <name>D6STK9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mn2+dependent serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871374.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1364"/>
    <dbReference type="EnsemblBacteria" id="EFI34025">
        <property type="protein sequence ID" value="EFI34025"/>
        <property type="gene ID" value="Dthio_PD1364"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1805065at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="283" mass="32417" checksum="4A31D3BEEAF84C44" modified="2010-08-10" version="1">MPDLIFKNKVSFRGWFVYFDGTLPSQDFLDMVLACASNSDCSFTRVASSQNARVYQASMQVQDIVKEVFVKHYLFRSRFDQLKHFLRSSRGKRALEATLMLRHNGFYAPKPVLLMEKRSGPFKTSSVFICEKVAGATSLKHLLQSLSQNNSARALGSKRSLIRDFGRTVGRMHARGIVHGDTRLSNVMVKEKAGKFLFWFIDNENTRQLPVLTARTVCKNLDQINIRAKVSNADRMRFFSEYCRERGLNPAESRKMAGMVMDRTAKRQDERAVRKPWKKAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6STS8</accession>
    <name>D6STS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1434"/>
    <dbReference type="EnsemblBacteria" id="EFI34094">
        <property type="protein sequence ID" value="EFI34094"/>
        <property type="gene ID" value="Dthio_PD1434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="53" mass="5990" checksum="FB1F5D492DD874E0" modified="2010-08-10" version="1">MNRVSLEFNRSFYRRPKNGYPLPSPGAINTMAPRVVVRTKGSKTTRPAQNQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU22</accession>
    <name>D6SU22_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type III restriction protein res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871805.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0428"/>
    <dbReference type="REBASE" id="38768">
        <property type="entry name" value="DthASO31ORFBP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33113">
        <property type="protein sequence ID" value="EFI33113"/>
        <property type="gene ID" value="Dthio_PD0428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16977at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021835">
        <property type="entry name" value="DUF3427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11907">
        <property type="entry name" value="DUF3427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="323"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="536"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1041" mass="118679" checksum="222B677236202997" modified="2010-08-10" version="1">MANKLAYGIYDALLDNRLQSILDQYPELRTVLGKIDTEEQPARYADLVAKVVRQVLREETDSDKRTLICNAILAQLYAGTEQQVNISQLVSGKKPVLLEITPPNYAKSGIPRPHTPIFESSLFTGSPRDPQLVHELLAEMKSADSVDILISFIKWSGLRLLMPAFEDLRDRRVPVRLITTSYMGASDAPAVEWLARMPNVQARVSYDTQRTRLHAKAYFFKRDSGFSTAYIGSANMSHAAMTSGLEWNLKVTEQDMLHILEKFTAEFETYWNSREFIPFDPDDPGQLREAISRARTSKARARVFFDLRPHPFQERILEELEQDRKVNNQHQNLVVAATGTGKTVIAAFDFQRFFQRKQKQVKLLFVAHRQEILEQAQDTFRNVLKDHNFGDLLVGQHQAEQVKHLFCSVSMITNRRLGEQVGRDFYDFIIIDEAHHGTAASYRPIFDNFEPEVLLGLTATPERMDGENVLADFGNRITSEIRLPEALEEKLLCPFHYFGVADPISLNEDRFWHHGRYNVAKLEKIYTGAHVQARQRLDVVLEALKRYEPELAQIKGVGFCVSIRHAHYMADMFSQHGIPSAALVSGIDNNQCASLLEQLRSGELTFLFTVDKLSEGVDVPDLNVVLFLRPTESLTVFMQQLGRGLRHAPGKDCLTVLDFVGQAHRKYRIDTKLKALLPRHRFSIDHEVEMDFPHMPPGCSIQLDRVSRKYVLENIRENLRNLAVQVPERMQSFENETGQQLTFGNFISHHDYEPERLLVKETWSGWKSKANLSAIPGDPDLKRLKNALIRIAQINGPREIARLRRILLHLQENDITQALATAGDTAISTHYRIWADKAGNLDMSSLEDSFTRLSRNPTILADMDEILAWAAGDSKIEGRQPGLVFESPLELHARYSSRDINAALGLADLHSPGPTGTGILHTKKIKTYALLLTFQKTEREFSPTTMYSDYPISRQRIHWESQSTNTQQGQTGQNLIHHREKGYTVLFFVREQKKSLGVTMPFTFLGPGEMISYEGERPIKMVWELQHPMPVEMFENNRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU34</accession>
    <name>D6SU34_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871816.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0441"/>
    <dbReference type="EnsemblBacteria" id="EFI33125">
        <property type="protein sequence ID" value="EFI33125"/>
        <property type="gene ID" value="Dthio_PD0441"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2064132at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7935" checksum="AE07C120EA136DF7" modified="2010-08-10" version="1">MKRTNVVLDEELVRECQVLTGIRTRRALIDYALQELRRRGRQKRLLELKGAVQWEGDLNEWRKGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU39</accession>
    <name>D6SU39_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871515.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0124"/>
    <dbReference type="EnsemblBacteria" id="EFI32819">
        <property type="protein sequence ID" value="EFI32819"/>
        <property type="gene ID" value="Dthio_PD0124"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2089718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="168" mass="19497" checksum="ADEEA03BD5793EEF" modified="2010-08-10" version="1">MDAKEAMLSAMKEWMLPELNSIREDYKNIKTTLDITNKRLDDMIAHLVDQGRRIDETRAELSSRIDETRAELKAEIQKNTERIDETNKRIDETNKRIDDTNNRIDDTRAELKAEIQKNTERIDYTNARIDNLAREVAEARGDLNKALSDKVVVQDLVERVGRLETRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU45</accession>
    <name>D6SU45_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871521.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0132"/>
    <dbReference type="EnsemblBacteria" id="EFI32825">
        <property type="protein sequence ID" value="EFI32825"/>
        <property type="gene ID" value="Dthio_PD0132"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330KK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1834457at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="206" mass="23180" checksum="D7B03BC13FD889A0" modified="2010-08-10" version="1">MHEEILTINQKKVAESVLKKFSPDFIFCGGTAIALQLGHRQSLDFDLASFTEIKADRIIRHLKAANVVIEHTIASSIDELTVVVKGVKLTFFSFPFHVPATVTWPRTDMAMPSLLDLASMKAYALGRRGKWKDYIDLYFLFQGHVTWPELVANCRKLFQGAFNERLFREQLCYFDDVDMSEAVAYTGTGPSDSDIQSFLTTLATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU51</accession>
    <name>D6SU51_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871527.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0138"/>
    <dbReference type="EnsemblBacteria" id="EFI32831">
        <property type="protein sequence ID" value="EFI32831"/>
        <property type="gene ID" value="Dthio_PD0138"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031KXS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1981116at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15080" checksum="9747C451224623F6" modified="2010-08-10" version="1">MTQPASVIDLYDSLLAAEDERARARIIAGAFERLEDRYPELKDLATASGVRESELRLQKEIEQLRLRIEEVRSDLTREIEQVRADLSKDIERLRAETSKEIAAGNQKILRWTTGLLFAQLVAIIAVIFGVALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU82</accession>
    <name>D6SU82_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871556.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0170"/>
    <dbReference type="EnsemblBacteria" id="EFI32862">
        <property type="protein sequence ID" value="EFI32862"/>
        <property type="gene ID" value="Dthio_PD0170"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YDN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1948244at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9758" checksum="6793A6B46336D090" modified="2010-08-10" version="1">MPEITRFLGIIISMYFDDHEPPHFHVRYNEYRAAVSIQELNVIAGYLPAKVRGLVQEWAEIYQQELLNMWITKDFHKINPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUH3</accession>
    <name>D6SUH3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="8" type="ORF">Dthio_PD0267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0267"/>
    <dbReference type="EnsemblBacteria" id="EFI32953">
        <property type="protein sequence ID" value="EFI32953"/>
        <property type="gene ID" value="Dthio_PD0267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="319" mass="35762" checksum="63B443A495152BA9" modified="2010-08-10" version="1">MQAQELADYTHQPVMLEKVLELLAPAPGGRYLDGTLGLGGHSLAILKACKGECSILGMDMDQEALELVAENLEEQQGGLHMVQDAFHNFQEYLQELQWPGLDGALLDLGMSSLQLDKKEKGFSFIHDGPLDMRMGLAQGFPPASSLVQNASFSRLKQIIYELGEEPMAPRIARAIIQAREKSPINTTLELARIVEQAYPAQRRRAARNHPATKTFQALRMATNKELESLQDFLEKIAPWLRPGARLVVISFHSLEDRMVKQYLRRQASDCICPPRSPVCSCSHRKTLEILTRKPLTASEREISRNPRSRSAKLRAAQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUH4</accession>
    <name>D6SUH4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871647.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0268"/>
    <dbReference type="EnsemblBacteria" id="EFI32954">
        <property type="protein sequence ID" value="EFI32954"/>
        <property type="gene ID" value="Dthio_PD0268"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033KYK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017690at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="11540" checksum="189040A0649C742F" modified="2010-08-10" version="1">MPEKKKEKKTGSYKWLAVMLLATFVLGMAKVWVTVERVDLAYRMERLQEEYRDNRELRTKLSIEKNNLLSPYRLREFGREHGLSRPGDEQVRKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUN6</accession>
    <name>D6SUN6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Elongation factor G</fullName>
            <shortName evidence="8">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fusA</name>
        <name evidence="10" type="ORF">Dthio_PD0330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871709.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0330"/>
    <dbReference type="EnsemblBacteria" id="EFI33016">
        <property type="protein sequence ID" value="EFI33016"/>
        <property type="gene ID" value="Dthio_PD0330"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="8"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="690" mass="76738" checksum="5FA5CE3813746C39" modified="2010-08-10" version="1">MSRLVPIDKQRNIGIMAHIDAGKTTTTERILYYTGVSHRLGEVHDGQAVMDWMEQEQERGITITSASTTCFWKDHRINIIDTPGHVDFTVEVERSLRVLDGCVAVFCAVGGVEPQSETVWRQADKYHVPRMAFVNKMDRTGADFFRVVDMIRDRLKAKPVPLQIPIGSEENFRGLIDLVYGKAYIFDDQSLGKKFDYIDIPEEYQEEAQKWRHHLVESIAEEEEALLDKYLSGEELTSEEIMGGVRKAAISLSICPVLCGSAFKNKGVQPLLDAVVSFMPSPVDIPPIQGVDPSTEETIICPPNDDDPFSALAFKLTSDPYVGHLSFLRIYSGKIESGMSVINAATGKKERIGRLLKMHSNKREEIKSAYAGDIVAAVGLKYTATGETLCTPERPVLLESIEFPDPVIEIAIEPKTKNDQNSLSNALQKLSKEDPSFRVNTDEESGQTLIAGMGELHLDIIVDRLTREFGVDANVGKPRVSYRETITKKIKQDTRYVKQTGGRGQYGHVVLEVEPAETGQGYEFVNSIVGGVIPKEYIPAVDRGIQDAMKSGVAAGYPMVDIKVNLVFGSYHDVDSSEQAFYIAGSMAFKEACNKAEPIILEPIMYVEALTPEEYMGDVMSDLNGRRGKVLGMEPRMGTQIIKAYVPLNNMFGYATDLRSNSQGRATYTMQFDHYDKVPSSLADEILKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUY1</accession>
    <name>D6SUY1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871835.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0023"/>
    <dbReference type="EnsemblBacteria" id="EFI32737">
        <property type="protein sequence ID" value="EFI32737"/>
        <property type="gene ID" value="Dthio_PD0023"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7QT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1217533at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025639">
        <property type="entry name" value="DUF4338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14236">
        <property type="entry name" value="DUF4338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4338" evidence="1">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="292" mass="34123" checksum="B491EFDB85BEBA87" modified="2010-08-10" version="1">MQTILRYRGRDITEEDVRFIRQLIFEHPGDSRWALSKKLCTAWNWVQQNGQLKDMVCRGLMLALHRQGHIILPPAQKVTATGYNRKEPVSVQVDQTPLTSSLKDITPLEFRQVRKTPFESLFSSLLKEHHYLGYTQPVGEHLKYLVFANKQPIACLSWSSAPRHIGVRDNFIGWTQKDREKNLFLIAYNSRFLILPWIQVSCLASHILAQMTKIVQRDWESIYKHPIYYLETFVDQERFKGTCYFAANWLYLGQTTGRGKNDHTGKANRSLKAVLGYPLTRDFRKRLRGLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV15</accession>
    <name>D6SV15_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase IS21/IS408/IS1162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0064"/>
    <dbReference type="EnsemblBacteria" id="EFI32771">
        <property type="protein sequence ID" value="EFI32771"/>
        <property type="gene ID" value="Dthio_PD0064"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="111"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="473" mass="54443" checksum="6F885D7E9E4CC935" modified="2010-08-10" version="1">MIDYELYARIKHYHEQKGLTPAQIAKELQLDPRTVGKWLEAKQFHQRKSVTRPSKLDPFKDTIVRMLEEHPYTAVQVLRSIKEQGYTGGSSILKEYISKVRPKRSRAFLSLAFAPGECAQVDWGNHGSIQVGDSRRNLSFFVMVLCYSRMMYLEFTVSQSMEHFLSCHQNAFDAFGAVPKKIMVDNLKCAVLKHPYGQKPVLNPKYLDFAKHWGFEISACGVRKPHEKGRVENAIGYVKKNLLAGLELPDYRAINHYARHWCRATANVRIHAQTGKKPVDMLEEEREHLLPLPVNTYDIGVVTQVRASSQFRITLESNRYSVPARYAGKRLTLKTYPDRLCIYDGNNLVARHIRSFDKKRDIEDPDHVQELIAQRRAARDQQLFSRFLALSPRAKDYYFELEKKHLNIKHHVQKIVALSEIYGSEAVSRAMDDAFTYSAFSCEYVANILEQRARTMPRTRSPASDQARGSAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJS3</accession>
    <name>D6SJS3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3579"/>
    <dbReference type="EnsemblBacteria" id="EFI36126">
        <property type="protein sequence ID" value="EFI36126"/>
        <property type="gene ID" value="Dthio_PD3579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="58" mass="6961" checksum="4651ECC23050AA26" modified="2010-08-10" version="1">MNMYFAVFLIVFLLAGLAYSTYSFSQGRFLEGMSIFPWLIACYFFVQAWERRNRNDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJU9</accession>
    <name>D6SJU9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869277.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3606"/>
    <dbReference type="EnsemblBacteria" id="EFI36152">
        <property type="protein sequence ID" value="EFI36152"/>
        <property type="gene ID" value="Dthio_PD3606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="155" mass="17414" checksum="6301D5F692DC8C47" modified="2010-08-10" version="1">MVQDKSLIKKRALGDFLSPLFTLPATSKTMGFYFLQFGVLFLFIWAVLVFMVAPNLIMPFGPTFYFSLLPGVAASVIFLSNGVKLIRKPELYNRPLARLLVPGMLFFLTVLGGYVAGRTEEASILSFWFGACGLAVTMYLGYAWRHYSRTAYKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJV8</accession>
    <name>D6SJV8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gp157 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869283.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3617"/>
    <dbReference type="EnsemblBacteria" id="EFI36161">
        <property type="protein sequence ID" value="EFI36161"/>
        <property type="gene ID" value="Dthio_PD3617"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DHI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1870508at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008840">
        <property type="entry name" value="Sipho_Gp157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05565">
        <property type="entry name" value="Sipho_Gp157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="18719" checksum="B3CF1DEACFC4EB1F" modified="2010-08-10" version="1">MASLADIEMEIANILATAEELPEEQQEVALEYLEELAIAEIEKIDAVGYAVRKRQSEIDFLKSEETRLRNKRQAMEKRLSDFKAYLAELFQREEIHKIKGVSTTAYLRRSSSVEVTDISQLPSDYVETRIDFVPRKSQIRDALKQGQEIPGARMQEKQSLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK40</accession>
    <name>D6SK40_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3700"/>
    <dbReference type="EnsemblBacteria" id="EFI36243">
        <property type="protein sequence ID" value="EFI36243"/>
        <property type="gene ID" value="Dthio_PD3700"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="318" mass="36006" checksum="46B10253111039D6" modified="2010-08-10" version="1">MKSPPYTPSSTKGLTLIELLVALAISSIVIALVLPLLLSNQRLVKVDQSRTAVFQNLRSAMEMVGTDVRIAGERLEQRGGPNIMPIEIVKGENGDPDELILRRNLLDYTLPVCDTLNADNAEHNINVRQVGNNPPWNNYPECQGHPGEVPHELEIWREYRDNQGGDVRIYIYDPIIKIGEFFIYDHDDSSDIQVHRKAGKWKNSYGNDVGNSGASEKLPKLYVLEERRYRLNTENNILELVINGNDEEVKNIAGEIFDFRVQAVMIDGSTVDEISTTSHWRNLKAIKVTLESKSSVQDETVQRTISSRFFPRNVMSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKD5</accession>
    <name>D6SKD5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869457.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3806"/>
    <dbReference type="EnsemblBacteria" id="EFI36338">
        <property type="protein sequence ID" value="EFI36338"/>
        <property type="gene ID" value="Dthio_PD3806"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1094814at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="133"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="324" mass="38013" checksum="EA9C3A75B6148B80" modified="2010-08-10" version="1">MKSNQNGDLEQFFPVSIYSIQPNKVNDFRIYIKRGNNYVLLTNKKEAFSLSQRDRLYNLNIETVYIPYNEAESYDRYLVENLDKILYDENIPLHERSKTFYNLATDLSYEVINEKLSSDYKFKDLLNVIDQTIDFLSKPENLASVRKLISHDYYSYTHSVNVFVYSAFLLNQYNYDKKDITYIGSGAFLHDIGKSLIPHHTLNKPGALNNKEWEIMKKHPEYGIEACSNLSLSYKTKFVIRNHHEKLDGEGYPDRIKKIPHYVQIVTCCDIFDALTTNRVYANKRSPFEAFKLMKDKMHKQINLDILATFIKFMGKSPETVHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKE4</accession>
    <name>D6SKE4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">Dthio_PD3815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869466.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3815"/>
    <dbReference type="EnsemblBacteria" id="EFI36347">
        <property type="protein sequence ID" value="EFI36347"/>
        <property type="gene ID" value="Dthio_PD3815"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="81"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="201" mass="22468" checksum="48FBDBCF9603D730" modified="2010-08-10" version="1">MQKLPRSMQLLVDRLSDLPGIGPKSALRMAMTLLKWPEDKTRGLGQSITDLRDQLCICSQCAALADTDPCSICSDAMREQDKLCLVSEWDSLLVMEESGFFKGRYLVLGGLLSPLDGVRPDSLELDKLRENLQSGQTSEIILALGTTLEAETTGSYIKNMVEKEYPHVRVTRLAQGIPLGSDLKFMDKETLKQSMRFRQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKH0</accession>
    <name>D6SKH0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBA/THIF-type NAD/FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869489.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3844"/>
    <dbReference type="EnsemblBacteria" id="EFI36373">
        <property type="protein sequence ID" value="EFI36373"/>
        <property type="gene ID" value="Dthio_PD3844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="48"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="262" mass="27889" checksum="A2F9A059B7448553" modified="2010-08-10" version="1">MTQQTIRTYISDQEILNRADKSGNPVQEEVLLAMEAGEIPLRYQRNNHALSLTDQISLARSAVLLVGCGGLGGNLCEYLVRMGVGKIVACDPDVFDESNCNRQILATSETLGEPKALAAKQRALAINPLVEVVAVEDFVRVDLLDSVQAVADCLGGADYRQELLEMSRSAGLPMVSAGIAGWHALVCTTWPGESGIGEFMGKSTSSAEVEQGVLAPVASFAASMQAGELVRIMTGASPALRGSLLMTDISRMRFSTVELNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKP8</accession>
    <name>D6SKP8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868392.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35259">
        <property type="protein sequence ID" value="EFI35259"/>
        <property type="gene ID" value="Dthio_PD2670"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030N32">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1612788at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="578" mass="65168" checksum="C778D80AB39CB0B7" modified="2010-08-10" version="1">MSEKMALGPYLKKIEDICEPLSKEELQGVILSIAREARVHERASFISRLSSYLPRGLDAPEPVEGASAEDILDGIEALKESILERIETIENGEYEELEDFEGHDIYDYEPEYVSEEQLEELGSFVDEAGRYFLNGELEPARQVYKAVFDLIHEADIEHYIQEIDMVEARARHSRCVYELTSGQQRIEAFWEVMVPDIADSGGFSPPDAYPMLQDVVESMVDPLPDFEGFLLQWESALSQEEVPGKRSAGLLLEAVGLRNDLNKISELARNWGDKQPQGYIFWLEQLAEKGSWKETADVSREALSRLSPGRQRDEASEYLVLAGKQLENDELVLEGKREAFFSSADITSLMLLIEEAEKNNLREKELDGAVEYLNTEEFKLFEQDMLVAVLLMAGRIEDAFAYSGDVTPVGWSYASPGGLLFSSILNMAGGLNEDCSVTISILDSYAGEISLQSSYHHFTVAMEEVEQECSSQIKKGLAIAMPRISGSELEKYFNWATEIGEKRIDHIVSNKHRKAYNRAASVLVALAETYAARGDKKKASSILKKYYHELFSRFSAFRAEVKGMLMESEILNNQKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKR4</accession>
    <name>D6SKR4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2688"/>
    <dbReference type="EnsemblBacteria" id="EFI35275">
        <property type="protein sequence ID" value="EFI35275"/>
        <property type="gene ID" value="Dthio_PD2688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8333" checksum="90C327A964739DD5" modified="2010-08-10" version="1">MKSCSISRKEVCNYLFSSDKWTEKGLKSMVDVYFLWTSQRTGSLLMNFYSYIYGKLNLPVGRRCRACRFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKR5</accession>
    <name>D6SKR5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868408.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2689"/>
    <dbReference type="EnsemblBacteria" id="EFI35276">
        <property type="protein sequence ID" value="EFI35276"/>
        <property type="gene ID" value="Dthio_PD2689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022472">
        <property type="entry name" value="VPLPA-CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03370">
        <property type="entry name" value="VPLPA-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088219" evidence="2">
        <location>
            <begin position="28"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="176" mass="19305" checksum="F6CEDE78BC04E6CD" modified="2010-08-10" version="1">MFLLKKCFVLAALCMLITLGTALPLKAATVYSGAWTPTSNSTEFFNVTFNTTGDSNFNFFLYNNNDAQLMIFERSQLWDAAQVGISRSDGTYSASLNGTSLVLGANPHFWLGYSLGNDTFHQYTYSLLTGNDQFLLKLGDKDIMISDASPVPLPASIWLLGAALVGLAGFSRRYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL06</accession>
    <name>D6SL06_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-aspartyl-peptidase</fullName>
            <ecNumber evidence="4">3.4.19.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.5" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868499.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2782"/>
    <dbReference type="EnsemblBacteria" id="EFI35367">
        <property type="protein sequence ID" value="EFI35367"/>
        <property type="gene ID" value="Dthio_PD2782"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="890789at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="305" mass="31623" checksum="8F6A8F6E4542E42A" modified="2010-08-10" version="1">MAVKYTLVIHAGCEDIIPERYGPEAEHEYLDYLHKSLAAGRVVLEGGGNGLDAVCAAVEVLEDCPLFNAGRGSVFAHDGTIEMDASVMRGKDLSAGAVAGVTGIKNPVQAAALVLKKSSHVLLMGTGAERFAHIHGLESAAPAYFQTSRRREEYLAAKKQAGEKFGTVGAVCLDRAGNLASASSTGGIPLKQYGRVGDSPVIGAGVYADNAACAVSCTGEGEFFLRRAAAKRIACLVEIGGFSLEAAVSAVLENIRNLGGKGGIIALDTAGRFSISFTTQGMFRGLVREGGMGRAAMFGPPGAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL25</accession>
    <name>D6SL25_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="12" type="ORF">Dthio_PD2802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868518.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2802"/>
    <dbReference type="EnsemblBacteria" id="EFI35386">
        <property type="protein sequence ID" value="EFI35386"/>
        <property type="gene ID" value="Dthio_PD2802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="256"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="519"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="778" mass="86780" checksum="7DA4A4AB3FC29B6A" modified="2010-08-10" version="1">MQTQDARASVWSAAILCQPYSSLSYALPPYLPVHVWHPGMRVLVPMGQSNKLCCAVLERSVPALPTEKKLKSIFWPLEKEAVLSADYLEMLENVAARQLTSLGRVLASVLPASLRRVPDGWRDRKNKKIPFSSGRDNREFLSRLAEFWMQGELDVKSPGGKEPALTVSSDPPWPIRPQARVQWAVMDLLYAHGPRTASSIRAELGQGSTKALQALQDKELVCPCKPGDEPEGGSLEAGQDFCFSPEQKEALKHLSPRLRQGFGACLLHGITGSGKTLVYLDLARQSLEMGRSAILLAPEIAIARQLYQQARQYLPGAAIYLHHGSKGPSSKEKTFVELGQEKKPVLLIGTRSALFMPVQDTGLIVLDEEHDESFKQDQTLIYQAKEIAWYLASREEALLVLGSATPDVKTFHAAQAGHVSLVEMHSRIGKSTLPQVDFVDLKNDPPVFGAMAKTCAEALKETVKRGEQAVIMHNRRGYSPVLMCESCSETVKCANCQVGLTYHKKRNRLVCHYCGISVSFPPVCRHCRGSEFIPVGQGTEKVEEFLARHLPDTQVLRLDRDSTRSPGKAEKILQDFAQGQARILVGTQMLSKGHSFPEVTLAIVLDGDLGLGLPDYRSSERIFQLLVQLSGRSGRGEKPGRVFIQTRNPGHFCWQYIRDCDYKGFFQQEISRRQKFGYPPFVRLGLIRFSFPDTWEGKADFLAGLRKKAKQAAAVSKVTMLGPAPAVLSRLKNRERHQFLVKSSDWAGIKQAYLELRPLFERYRQVRASLDLDPVNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL51</accession>
    <name>D6SL51_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868544.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2830"/>
    <dbReference type="EnsemblBacteria" id="EFI35412">
        <property type="protein sequence ID" value="EFI35412"/>
        <property type="gene ID" value="Dthio_PD2830"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="147"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="374" mass="42235" checksum="0CCE887B56B742C7" modified="2010-08-10" version="1">MLFILAFFLVYLGMHCFTWARFAAQFEFSSRVRRGGFRLCLLLALSPIAAHLIPLSWPEPLVYLIWQIVFTWLGVIFYLFLLQLALFVLQLMVWPVRVRISPGLSRAAAFAIITVTILTVGWGFMEAAGPVRVTEYEISSPKIGNDLRVVFLSDTHLGVQKSMQRVKDLKSLVHDQDPDLIILGGDILNDHLEWLQEEARIMQGMQAGLGKYAVLGNHEFYAGADDSRDFFARAGFTLLEDETEKLSETNIEIIGVSDPAPHGRFRQHQENVTKQLTRRLDPDKYNILVSHRPWGFEIARDAGVDLHLAGHTHKGQIFPFRFFVRLKYDHVYGIRRSNDSSLIVTSGAGSWGPPIRVLAPPEIVLVKISPGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLC8</accession>
    <name>D6SLC8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum ABC transporter, periplasmic molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868621.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2912"/>
    <dbReference type="EnsemblBacteria" id="EFI35489">
        <property type="protein sequence ID" value="EFI35489"/>
        <property type="gene ID" value="Dthio_PD2912"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1506401at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087969" evidence="4">
        <location>
            <begin position="23"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="252" mass="27655" checksum="DC037A83A6DC1737" modified="2010-08-10" version="1">MPRITTLFLLSFFLLLSWPVQARELIVSAAASLTEAFEEISAQFEADNPGVRIIRNYAASGALYRQMTQGAPVDVYAPANMHWMQEAARAGLVEAGNLHVFAQNQVVLAVPGSDKPDISTPEDLRLGRIRRIGITSPATSPAGNYAMISLKNLGLWNELEQKMIYAETVTQLMDYIRRGEVDAGLIYASDILRGQDEIHKKYTMPLDTPPAYPVAVLSSSTKPGLARKFVDLVLSQKGQAIMEKNGFQAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLE6</accession>
    <name>D6SLE6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="6 12">2.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Phosphotransacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD2931</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in acetate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + phosphate = acetyl phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19521"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">In the N-terminal section; belongs to the CobB/CobQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="6 12"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868639.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2931"/>
    <dbReference type="EnsemblBacteria" id="EFI35507">
        <property type="protein sequence ID" value="EFI35507"/>
        <property type="gene ID" value="Dthio_PD2931"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1301815at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016475">
        <property type="entry name" value="P-Actrans_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006107">
        <property type="entry name" value="PhpActrans_proteobac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DRTGG" evidence="14">
        <location>
            <begin position="217"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="PTA_PTB" evidence="13">
        <location>
            <begin position="378"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI35507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="698" mass="77031" checksum="8A28E3B27255A839" modified="2010-08-10" version="1">MAKNLFVINTEPRSGKSAVCLGLMQMLRRNIRKVGFFRPIINTLQEGKVDHDIHLILSRFQLQQSYEDAYAYTLEEARDLINQGKHYVLMENIMSKYKALEKNCDFVLCEGTDFVGTDSAFEYDINAEIAANLGSPVILITNAQKKNPKQVVSQTQMAIDSFIEKGVDILATIINRSRVEDKYEILSGLRCKFRDEADCLSFLIPEVESLGRPTMHDVHKWLGGEVISGQDFLDVQVDDYLVAAMQVNNFLDYVTQNSLVITPGDRSDILLGCFSTRQSRAYPEVAGIVLTGGMHPPASMTRLLEGWAGVPLPILAVEGHTFKVARILTELYGRIDPEDEKKVATALGSFEEHVDTEALLSRLEAKRSTRVTPIMFEFSLLEKAKADKKHIVLPEGSSDRVLQAADILLRRGIVDLTILGEPDRMRTRASQMGLHLEKALLLDPTSSKEFEDYADTYLELRKAKGVTPEVARDTMSEPTYFGTMMVYKEHAHGMVSGSITTTQQTIRPALQFIRTKPGISLVSSVFFMCLPDRVLVFGDCAVNPNPSAEQLAEIAISSSETAVQFGVEPRVAMLSYSTGESGAGEDVKKVRQATEIARSKAPELLLEGPIQYDAAYDPEVARAKMPDSKVAGRATVYIFPDLNTGNNTYKAVQRAANAVAIGPVLQGLNKPVNDLSRGCTVADILNTVAITAIQAQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLH2</accession>
    <name>D6SLH2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868665.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2957"/>
    <dbReference type="EnsemblBacteria" id="EFI35533">
        <property type="protein sequence ID" value="EFI35533"/>
        <property type="gene ID" value="Dthio_PD2957"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZWK8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="270" mass="30660" checksum="DBC1E4D8185A1CBD" modified="2010-08-10" version="1">MHDYLLFYNKIWPGKSNVVLLVLVFSCLVFPQKIHGDWNDPLQGLPQVMEFGAYLPDPDEEQEAVVTQIWVRTSASGHLQLLDSAKRPVAGDESSSPVVFFQVFQDPDHAEDQAFFVQFVPQGNKLGTRRLIRVHPGENIYISLDRGLADQSWTLNRVRMQDFGLQAQELESVVSVDSVFDEEALTQELEELLRVSTVHPGEDPAGKVHEQLGQTEDSAAAGMFSKGMDFMGRGEYSRALEYFEQSQEMEPTPELADRIRRLRSYIELQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLJ5</accession>
    <name>D6SLJ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2982"/>
    <dbReference type="EnsemblBacteria" id="EFI35556">
        <property type="protein sequence ID" value="EFI35556"/>
        <property type="gene ID" value="Dthio_PD2982"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1006904at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="29736" checksum="C2909DED68C938E2" modified="2010-08-10" version="1">MNSDLNNLSFDEIKKDGQITVKKTQWESKAEWVKTNIDDIYGFFGSIENQVTNGVYGLWMQPYIDYFGALLYMPILDVEHPENHHESPWYNINVAKGLFYRFNELGLTQDLTVGLTGKGFRFSWPWVIPHQYTNAFLVMVKDSERFYGIDPAPQKGKDKFLRTMAYRGNNNQGAPTQNTHIYYLDHASQISDLTEAEYKKLVRGRPAVEGYKSFLPRLMPNKFAPREFLEVLETYQFQLRIKSTIATPAAPRIAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLJ6</accession>
    <name>D6SLJ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopG domain protein DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868689.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2983"/>
    <dbReference type="EnsemblBacteria" id="EFI35557">
        <property type="protein sequence ID" value="EFI35557"/>
        <property type="gene ID" value="Dthio_PD2983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7622" checksum="62F0700942047986" modified="2010-08-10" version="1">MKKRSRFTLNIDAQTIAMLDSIACKNHLSRSAVLRMLLHMLKDLPKDYLDEISPLGKFLKDGAYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLS5</accession>
    <name>D6SLS5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868765.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3065"/>
    <dbReference type="EnsemblBacteria" id="EFI35636">
        <property type="protein sequence ID" value="EFI35636"/>
        <property type="gene ID" value="Dthio_PD3065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="299" mass="32381" checksum="A6141CFA607BFA76" modified="2010-08-10" version="1">MSVKDVAIIGQGPAGLSAAIYTSRAGLDTLIIGCAPKVAGDYDIDNYFGFPAGIKGNELIELGCEHAAKYGTQLSCEKVLAIHMQPDMTFKIKTDYGEYQARTVILATGVSRVRPGIKNISEYEGKGVSYCVSCDGFFFKGKKVVVVGEGVFAANQAIELKEYTPYVSICTQGKEPEIPENYMQHLQELDIEIMKGKIQNLEGEQFLEKAHFEDGTTLDVDGLFVAMGEASSLDFAYSLGITTQKNFIEADHEQKTNVPGVFAAGDCVGRFLQISVAVGEGAIAARSAIKYIKGLRKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLW5</accession>
    <name>D6SLW5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868805.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3105"/>
    <dbReference type="EnsemblBacteria" id="EFI35676">
        <property type="protein sequence ID" value="EFI35676"/>
        <property type="gene ID" value="Dthio_PD3105"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029461">
        <property type="entry name" value="TT1561-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14582">
        <property type="entry name" value="Metallophos_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_3" evidence="1">
        <location>
            <begin position="131"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="222" mass="24578" checksum="D4E39FD86EBCDC0A" modified="2010-08-10" version="1">MTEKHWIAVGDIHENAVNLQRIRKISEARGILVSGDLTNVGGRSTARMLLDEIRKVNPNVYAQIGNMDTREVDRFLEESGVNVHNRIVLLEDDVYLLGLGYSTVTPFNTPSEVSDEQLEEWLLAHRDKASRIKHLIFMTHTPPYGTKTDMLNSGANVGSRAVREFIEDVQPEVCITGHVHEANIEDHVGGTKVINPGTLSGGGYVVIRYDGVGLDAHLKQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLY8</accession>
    <name>D6SLY8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3128"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0711">Selenium</keyword>
    <keyword evidence="1" id="KW-0712">Selenocysteine</keyword>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="100" mass="10882" checksum="6365DF27F8798F87" modified="2010-08-10" version="1">MFELSDTAKMQLDKFFETQEKAPIRVYLAAGUGGPRLALALDEQKDNDNVYDLKGFQFLVDKNLMQTVAPIQLDMTEGGFVIKSSLQASAGGCSSSCSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SME7</accession>
    <name>D6SME7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868987.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3297"/>
    <dbReference type="EnsemblBacteria" id="EFI35858">
        <property type="protein sequence ID" value="EFI35858"/>
        <property type="gene ID" value="Dthio_PD3297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1536958at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="197" mass="22756" checksum="505A5EA1D68D2F92" modified="2010-08-10" version="1">MTLETELKYFVSDFAPILERMERLGLSCTHWYFEENLVLDTGDGRLRSRDELLRIRKGQGGKITLKLPVDGADSSCKQRQEFESGVDNPDEIRIILSHLGFRPCLRYEKFRRICSLGETMICLDILPFGSFVELEGPQESFHGTAIELGLDSHEKTALNYHELNQEYRREQGLSPALDFVFEENQKKDLARKLNVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMI4</accession>
    <name>D6SMI4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="7">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nadD</name>
        <name evidence="9" type="ORF">Dthio_PD3334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3334"/>
    <dbReference type="EnsemblBacteria" id="EFI35895">
        <property type="protein sequence ID" value="EFI35895"/>
        <property type="gene ID" value="Dthio_PD3334"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="8">
        <location>
            <begin position="16"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="238" mass="26942" checksum="2F0280205EE20FA8" modified="2010-08-10" version="1">MAPLDCMSNKTPRIGLLGGSFNPVHIGHLRLCLEMLEQAGLDRVELVPAYIPPHKDPAGILPFAMRLRMLQESIDGVAGLEVNPLEQDRPGPSYTVDTLKAYRSEYPEYELNFILGDTDLFTLPKWHRGQELARLSNLLVIGRQGEHFQVGVFASRFWKVEQENEKCWELENGKRISFYSVPRLEISSSMIRSRWLAGKSIDWLVPFRVRDILAGSSGEVRTLWEKSSAQAAKTSDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMM4</accession>
    <name>D6SMM4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869063.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3377"/>
    <dbReference type="EnsemblBacteria" id="EFI35935">
        <property type="protein sequence ID" value="EFI35935"/>
        <property type="gene ID" value="Dthio_PD3377"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968249at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10030" checksum="8C1436DED49AD920" modified="2010-08-10" version="1">MATQASDIKNKLQEIYPEIAQYGVGLQIDYNSEKKAWEATFEKDGNTLSTHLEDTDVDNCLLGKKCYNFGIQLGQFIRNYCEGGEACKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMM6</accession>
    <name>D6SMM6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Export-related chaperone CsaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869065.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3379"/>
    <dbReference type="EnsemblBacteria" id="EFI35937">
        <property type="protein sequence ID" value="EFI35937"/>
        <property type="gene ID" value="Dthio_PD3379"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2038415at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008231">
        <property type="entry name" value="CsaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF37">
        <property type="entry name" value="PTHR11586:SF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02222">
        <property type="entry name" value="chap_CsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12331" checksum="74E9A8669260FB60" modified="2010-08-10" version="1">MSQIDWNDFQKVDIRVGTITEVHDFPKAKKPAFRLVVDFGQEIGTLKSSAQITDLYDRDSLPGKQVIAVINFPPRQIGPVMSQCLVTGFHDQNGAVVLAVPDAHVPDGTRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMT1</accession>
    <name>D6SMT1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP dicarboxylate transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869120.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3434"/>
    <dbReference type="EnsemblBacteria" id="EFI35992">
        <property type="protein sequence ID" value="EFI35992"/>
        <property type="gene ID" value="Dthio_PD3434"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="903568at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="12"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="435" mass="46065" checksum="9B99CC845520F91E" modified="2010-08-10" version="1">MSPFELGIAAILLVFVLIAARMPVAFVMLVVGVGGYAYLISLDAALSIASSSIYNTFASYSLIVVPLFVWMGYIAYHAGISRRIYDATYKVVGRLPAGLALATIGASTAFGAICGSTTATAATMSAVAVPEMKRYRYDRSLATSVVASSAILGVMIPPSVIFIIYGIATGESIAKLFLAGIIPGVLLMGLFMLVTWIRAVRNPDLAPAGPEVDLKGKIRAVAKGGVEVVIIFIVVIGGLFLGYFTPTEAGGVGAAATLAVAIIRRQINWTGFKNSLRDTIRISAMIMFLVAAATVFGRFLAVTNIPTTMAVWAGDLPIHPVAVLAIILLIYLLLGCFIDALALILLTIPIFYPVAVHLGFDPIWFGVIIVLVVGMGVITPPVGANVYVVAGIVKDTPVVTIFRGVWPYLLSIILCIAILTLFPQLALFLPDLVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMW1</accession>
    <name>D6SMW1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative regulatory protein Dthio_PD3464</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RemA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869150.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3464"/>
    <dbReference type="EnsemblBacteria" id="EFI36022">
        <property type="protein sequence ID" value="EFI36022"/>
        <property type="gene ID" value="Dthio_PD3464"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786332at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01503">
        <property type="entry name" value="RemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38449">
        <property type="entry name" value="PTHR38449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10559" checksum="79B80129B0F35637" modified="2010-08-10" version="1">MDSNIYKTRFRLLNIGYGNSVIISRVVSIVNPGSSPMRRLREDARERNMLIDATQGRKTRSILVMDSGHVILSAVQPETMAQRIKQLEARDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMW9</accession>
    <name>D6SMW9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD3472</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869158.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3472"/>
    <dbReference type="EnsemblBacteria" id="EFI36030">
        <property type="protein sequence ID" value="EFI36030"/>
        <property type="gene ID" value="Dthio_PD3472"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="303"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="375"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="505"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="622"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="742"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="797"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="866"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="915"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="1308"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="13">
        <location>
            <begin position="1508"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1027"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="1357"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI36030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1599" mass="181765" checksum="59F58E4A104CDE5F" modified="2010-08-10" version="1">MTRPSKKQDHPGPASFQNSHDILMNAPIGIYTSTPEGRLLSVNPALARMFGYDSPQDMMESVTDIASQLYADADDREKFKRLLSEKEELVNYKCRMRRRDGTIFWTSKNAKAVRDKDGNVGNYQVFVTDISDRKQAEEELKKKERKYRQLFEASPISLWEQDFSQVKKRIDSLKAQGIPDLRAYLRENPDLVKELANLVKVVDVNQVTLRRYHASSKEEFFSGITTVFSEASIEGFLEAPIAIAEGRQELFVENKHLTLDGKPLEVQVHWSVAPGHEETYSSVLVCIVDTTELKEAEATLKESEEKYRLLVENLNEGVWQIDKDGYTTFVNNSMAEMLGYSVQEMLDRHLFDFMDEQAVSIARKNLERCRHGVREQLEFEFIHKDGRRIYTLLASSPIFDQDGNFTGYLAGVQDITKRKQAEKELMFQNILMKTQLEASPDGIMVVDENDKIISFNQRFAELWELPDSIMSSQSADKALKHVLSKLAYPDEFVRRIHELCNNKTEESCEEIVLADGKIFERYSSPISGPSGDYYGRVWYYRDITDRKKAESALRENQYLLSTIFDNAPIGIWVMDHDQKPLLVNSYFKENTGLGTDSVSLTSDELAACKKSDDMVLNGHDPCHFEEGVTFKDGRKHMLQTIKTALAGGDGRIKGVLGIGVDITERKRLEQELKEQVNILEAIINGIPDILAIQYPDHSIERYNKTGYQVLNKTPDEVRGKKCFELIGKERECEECATRTALRTKELAQLEKYIPELDIYLNCRSVPIVDEHGEVVKIVEQLRDITSRKLAEEALKKSEERYRSLVESQHDAIARIDREGLFTYVNDTCCRIFGKKREELLGSPFIPYVHEEDMEYLLTNLEKVHQHPHRVQIAHRLVTPSGFYWMHWENSAIFSDSGDIVEIQSVGRDITEMKLQQQKLELILKAAQNVSFVLTEPANDQQDHLIRDFSPGAENILGYNKEEVLGKSVFMLHSEENFEKVPEIHAAVARNQPWHGRVWLVRKSGEKYPALFTVYPFNLYSRMGMLGVSIDISELEKAQQELIQAKEQAEAANRAKSTFLANMSHEIRTPLTGIMGSMEMLASEISSENGRRIMDMTRESARSLQRIIDDILDLSKVEAGRMELSSREFVLSAVLDRVQGLYAAQAENKNVRLSKSLDPGVQDNLLGDASRLEQILRNLVGNAVKFTSHGQVTLRARPADSQDGSSKQVVRFEVQDTGPGIPEDKLTDIFESFTQADSSFKKSHQGTGLGLTICRQLTRLMGGNINVESAPGEGSTFVAEIPFEVVGQKHAAGRIQKTEPKESRPAPLNILLAEDVQLNHDYIRFVLEKDGHRLHSAYTGQEAVQAYQEGSFDLILMDIQMPGMDGMEATQQIRSMEQGAWSMEHGARGMEQRTEDRGQKVGERIPQSLNPPIPESLNSPIPQSQNRIPIIALTAYAMQEERDSFLEAGMDGYVSKPVDPEGLKQEIQRLAYSWQAGQSKDQKEQTALDAKLHDVVDMDEVYRRFMGDTQIWREMMGDFVHNEAQVYISCLERAWKEGDVQEINRLSHKLKGATGTLCINRITHQATEVHEESKKQESRHLENLLINLVQSLKGLLDSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN89</accession>
    <name>D6SN89_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869543.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1566"/>
    <dbReference type="EnsemblBacteria" id="EFI34215">
        <property type="protein sequence ID" value="EFI34215"/>
        <property type="gene ID" value="Dthio_PD1566"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643083at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="148"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="373" mass="41889" checksum="58C43E3427C5A39F" modified="2010-08-10" version="1">MDYQNNSISKLETALARIGVSEQARPKMISALREVEDCLMDIDFDARLELVAPVLDALHRDVHILEKKVRIEPELPVLHFKYYYRSAIARGLVLSRPEISDHVWEPQTTRLFLHLVRGASAVAIGGAYFGDHALLAGQMLQFSENTRTARVHCFEMNSEQLDLCRVNARENKVSNLVFHHKALYSRSGVHLGLTGDDAAACAHEVSPNTDDAVPAVTLQEVAQEHGLDSFQVIMLDIEGGELEALKGGEAFLTLPPGQAPDIIFEVHRHYMDWSAGLDNTDIVRYLRSYGYHVFAVRDYQSNVDLRGYPVELVSPETAYLQGPPHGFNMVAVKRVSRLQGPQFRFVEHVSPKLLFHRDPALHAPLVRSEAPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNA5</accession>
    <name>D6SNA5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase, family 4, conserved region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869559.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1582"/>
    <dbReference type="EnsemblBacteria" id="EFI34231">
        <property type="protein sequence ID" value="EFI34231"/>
        <property type="gene ID" value="Dthio_PD1582"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="558" mass="62259" checksum="073BDE6FE0691C7A" modified="2010-08-10" version="1">MTLSDHQVQEMVILGLVFFVSLLMALFLTPLFDRAAWRLGLTDSPGGRKSHARCVSRAGGLAMAGALFFTLTLLLKWNSQLGAYWAGAAVIISAGVADDKFRLSSRVKFAAQALAVTAFVYLGGMQLHNLGDILGFGPIEPGWAAPLLTVFAMVGVINAFNMSDGLDGLAAGLAGIACLFFIPFAYAQESWIYLLILTGLFGTLLGFLRYNVHPARLFMGDSGSMFLGFTLAAAAVVLTQGEITGVQEYEPVTALIILSLPIWDTLYVMTRRLVNGNNPFKPDRLHLHHRLMDLGISHNVTVSLVYCLMFFMGISAWLIRPWPEWVQFYSLLGFYSLFYGGLWFWERRTSAPKKTYAPRTGLQEKLQPLMIANFRQRKKIFILIWGGCALPAVMMQGSGPGLLYYVAFILLFTGFYYPWRGGSKHVPIGHGLMFFGIYSLLLVYNAGFAHSAWFEPYMWSLAGLAGLWTLLRVLDTVRLRVLVPGCFEILLLGAAVVSPVLLHYSLGIDEQIRRFLVLSFVQSIPLFLMLKAYLRRDQTPNRRFMLYLMLLFLLVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNB5</accession>
    <name>D6SNB5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869569.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1592"/>
    <dbReference type="EnsemblBacteria" id="EFI34241">
        <property type="protein sequence ID" value="EFI34241"/>
        <property type="gene ID" value="Dthio_PD1592"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030256">
        <property type="term" value="C:type I protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030253">
        <property type="term" value="P:protein secretion by the type I secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010128">
        <property type="entry name" value="ATPase_T1SS_PrtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222:SF0">
        <property type="entry name" value="PTHR24222:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01842">
        <property type="entry name" value="type_I_sec_PrtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="10"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="320"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="548" mass="60739" checksum="DDBC214F214EC089" modified="2010-08-10" version="1">MKKELRRVLIISIGLSIFVVLLTLSLPFNMIMLFRWVVPSESISSIAVIAMAAVGGLLFMTIFDVLRFALLRRFAKYLNHQLGEKILHKMFQERALGQKGDASTAMSDLSKVRGFLNSPTSTAFLDTAISPLMLLIVFYISPLMGILAILCIMVILGTKLATRKSTRELLRRSNMGFARANNFAQECVHNSQAVRAMGMQPQLIHKWRGMQDEMVRDQTEASEKAGVHSAITKSMGWIMQVLLMGVGFSLMLMGEIDSALVIIAVIIAGRVIMPMQMAVDGWQNYQDAKDAFHRLKSYLEGMEEKEKEVSLKLPEPQGNLKAESIVYAHGGKPIIKGVSFDLQAGQTLGLIGPSGAGKTTLARIMTGAVRPQNGILRLDGADMHQWDQEQLGPHIGYLPQEVELFAGTIAQNIARFQEVSLEEIREAARKAGLEEIIESMPQGFETMLEERGLNLPGGLRQRIGLARALFGDPRILILDEPDASLDQQGIDSLTEILKRSRDEGKTVILVTHRPKLLQFTHQLLMLKNGQVAMYGPSKQVLQKLLPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNI2</accession>
    <name>D6SNI2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1659"/>
    <dbReference type="EnsemblBacteria" id="EFI34308">
        <property type="protein sequence ID" value="EFI34308"/>
        <property type="gene ID" value="Dthio_PD1659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="8098" checksum="B1857844A016C1EB" modified="2010-08-10" version="1">MNCTNPLGEKPMQNSISPFFGLGFDLGRTIRMARTISFHRPHVFEEPLFNPQHVLPSGFELLVLLNRETGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNL2</accession>
    <name>D6SNL2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869666.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1689"/>
    <dbReference type="EnsemblBacteria" id="EFI34338">
        <property type="protein sequence ID" value="EFI34338"/>
        <property type="gene ID" value="Dthio_PD1689"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1647539at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="132" mass="15101" checksum="543A09FA668C4A71" modified="2010-08-10" version="1">MTKLLFDSFALLRFLQKEPGADKVSELLQRVVSGQTEGFINAINVGEIIYLTQRRFGEQKKLETFIHLKRLKLKILPCPNELIYRAAEFKARHPISYADAFAMASALENDAPLVTGDPEFRQVSHLVRIIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNS5</accession>
    <name>D6SNS5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase associated with various cellular activities AAA_5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869724.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1756"/>
    <dbReference type="EnsemblBacteria" id="EFI34401">
        <property type="protein sequence ID" value="EFI34401"/>
        <property type="gene ID" value="Dthio_PD1756"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="489714at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="382"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="649" mass="75406" checksum="A5A4BBBB6E3DA2C7" modified="2010-08-10" version="1">MIKPPQKMIDSFLEWYKKDVHAENEDYYHETITLDYLSGLSRSDFIDFFYNFAHEGGRVQSGGYRTSKQFRETINSQYEQFLPFILSPFEAKFDELQWLNRIEDFKYFGNGLATIYLNRVDKKRFPILNNKTAKALQLFDIKLSSKTIERYQDTKAAQQKLIDWFPELENFFRVDSLCHFLAGEKEGKKIADELLSNLRNTPNDDENSKHPVQKKDFGTLPSLNTILYGPPGTGKTWKLRKEYMDQFTDTSATLSQEEYAARLVSDLAWWKVIAMVMMDLKESRVSEIMGHPLMQARIKRSSSANPRAAIWAHIQMHTKQECQNVKYTKRYEPLLFWKGDNSVWSIDLELAEETVPDLKEKLEEFNSFEPGKPTKVERYDFTTFHQSFSYEDFVEGIKPVMPAEDATEEIPDSLTYEVRPGIFKKMVQWAQADPEHNYALFIDEINRGNVASIFGELIALIEEDKRQGAEHELTATLPYSQTKFVVPKNLYIIGAMNTADRSVEALDTALRRRFTFIAVQPEPETLPAAGEVEGLNVDLRKMLYTINARIQKLLDKDHCIGHSYFLGVRNFQDLQGVFATKILPLLEEYFYGDPARIGMVLGEKFVSRNYESINWASGDWGQEEFDERHIFVIKDPRSLSQEDFQSIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNU6</accession>
    <name>D6SNU6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1780"/>
    <dbReference type="EnsemblBacteria" id="EFI34422">
        <property type="protein sequence ID" value="EFI34422"/>
        <property type="gene ID" value="Dthio_PD1780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="50" mass="5461" checksum="FCACBA148F7AA7F0" modified="2010-08-10" version="1">MRAPLEALGYEITGELPVYGIFDRGKVKQEDNVVSQAQRLGADLAGSLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP21</accession>
    <name>D6SP21_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34497">
        <property type="protein sequence ID" value="EFI34497"/>
        <property type="gene ID" value="Dthio_PD1856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="7840" checksum="F89F305CF78EAA8D" modified="2010-08-10" version="1">MMLKWVPECLSPAFLKSAKQILFVHGLQCMLSAGMSLYRISASFKDHFESAHLDGIVVDYYNAWLFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPA5</accession>
    <name>D6SPA5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane chaperone Skp (OmpH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869901.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1953"/>
    <dbReference type="EnsemblBacteria" id="EFI34581">
        <property type="protein sequence ID" value="EFI34581"/>
        <property type="gene ID" value="Dthio_PD1953"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1854604at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087903" evidence="4">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="172" mass="19975" checksum="7663EF3B35C5A62A" modified="2010-08-10" version="1">MKKTVLLLIICLLVPSMALAENKIGIVEVQRILESSEPGKQALGQLTLRFEEMRDDLEEERAEVERLREELQKQSMVLSQEAQQDMEAELRQKMQQFQQKYQSYQARMQQEEQELSDPIIDLLFEVIDDFAEKNGFDMILDAQGSGIIYAKDAMNVTDELMDEVNQAWEARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPA9</accession>
    <name>D6SPA9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="7">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lysS</name>
        <name evidence="10" type="ORF">Dthio_PD1957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7 8">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869905.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1957"/>
    <dbReference type="EnsemblBacteria" id="EFI34585">
        <property type="protein sequence ID" value="EFI34585"/>
        <property type="gene ID" value="Dthio_PD1957"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="188"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="508" mass="58577" checksum="22B5DFAB44FFA4E3" modified="2010-08-10" version="1">MKKNSQTPENTPDQSESQLLKNRRQKIKDLQEQQVELFSNSFRKDTDISRILQEAGSLDAAELEADTRCYRVAGRIMALRSFGKVIFAHILDHSDRIQIFVQRDMLGENEFKVFKKLDVGDIIGVHGALFRTRTGELTIKAEEIQLLTKAVRPLPEKYHGLKDVETRYRQRYVDLIVNPSSKQIFLARNRIIRYIRDFLDARDFIEVETPMMQAIPGGATARPFNTHHNALDMKLYLRVAPELYLKRLLVGGFEKVYEINRNFRNEGISTQHNPEFTMLEFYRAYVDYWDLMDFTEEMISGLCRHMTGGTQITYQGNTIDFTPPWTRIPFFKSLEEIGGLAPEDYQDPEKAKALVKRLGENVVPGEKQAKVQAKLFDLLVEPRLQQPHFIYHYPTEISPLSRRNDKDPAITDRFELFIAGREIANAFSELNDPQDQKGRFQEQVQDKEAGDVEAHYMDEDYIRALEYGMPPAGGEGIGIDRLVMLFTNSASIREVILFPLLRPEAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPC3</accession>
    <name>D6SPC3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869919.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1971"/>
    <dbReference type="EnsemblBacteria" id="EFI34599">
        <property type="protein sequence ID" value="EFI34599"/>
        <property type="gene ID" value="Dthio_PD1971"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="238"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="365" mass="40828" checksum="9BB94F46EAF68026" modified="2010-08-10" version="1">MPEEVKNQAQREMERLEKRKRLAYMVALACGVLIFLLSWIIREPDDLFILVLYPFFALVLALMLFFVWRRSFPLQQLEAVMFTAVSAMILGRLAWHFHLGGELDDHLLMLAGGHYWSVGVLIVGGFVMLDHKKGIIAGTLVILASISIAATGIAGELQDQEVSGQALIYLARIHLFLGLLLGLAAAATTLRDKYRDALIWNNSLQELASTDMLTGLANRRAAEDFLEKQAYANRRYGRKVSVIMADVDLFKQVNDKYGHSRGDMVLVELGRILRNSLRETDLVARWGGEEFLIVAPEIDMQEAKELAERCRCAIASRQVAGINLTMSFGVTELREKDSVDTVLSRADNLLYKAKSSGRNLIVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPF5</accession>
    <name>D6SPF5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2003"/>
    <dbReference type="EnsemblBacteria" id="EFI34631">
        <property type="protein sequence ID" value="EFI34631"/>
        <property type="gene ID" value="Dthio_PD2003"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="244" mass="28451" checksum="998F57C1960FD069" modified="2010-08-10" version="1">MRMSQDKYPALAEKYMLAGVGEMFSGMLHNLNNHVQILEMQHSMLKSRLESGPQTPIQEYAQKIEHFSREITGLAENVHTNAEHVYYTRKDQAQVNMGQYVDWLMNFWRNNPYFKHRVNCTVQVQSRDINLELPPFCLTLCLEQGIRNAVEDYTLLYPDQERSLALHAESSGDKGAFFRIVSQSELREPEPWKEGSSSKPDHLGMGLPVVEYICNCMGWEVELRNKQDETWFELKIPFKKSSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPM9</accession>
    <name>D6SPM9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870025.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2077"/>
    <dbReference type="EnsemblBacteria" id="EFI34705">
        <property type="protein sequence ID" value="EFI34705"/>
        <property type="gene ID" value="Dthio_PD2077"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="947558at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="43"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="615" mass="70859" checksum="CFE823FA6AB92FD2" modified="2010-08-10" version="1">MNYQKFFGFKEAPFHQSPDPAYYFSSETHREALQLLVYSIRAGEGFVQVTGDPGTGKTMLIRTILRELGEDMCVALVFNPRLSPQDLLRALLEDLGHDPAMLEELTRETMLRRLKAFLLEQASQDKRVLVIIDEAQNLPLDTLEELRLLSNLERDKEKLLQIMLVGQRELEQRLDQPEVRNLHQRITIRYRIRRLGRQEVQAYIHHRLRIAAMDQRAVQVQFDARALRAIYRFSRGIPRVVNILCERSLMSAYVVGRKTIYVGDVKKAMTSISGRQDEYGIKFFLRSRKPSAALVTALLLVVLFAGWLHRPEIVQTLSSLWAEQETQVEKTREPAPAGADDPEINLAALHRDTSAFWKSLETDKAAKDESDTLQNPPQEVFSASPGSSYVRVLTDVGHLQVWKKDQEGHTLSYSMEIDWPYGQGIFLMGKDPDQGEYLYNYSGIMGESPFRKKSPFFKHVDHLVPGNAVPVLAVQSEYNINDLHLDKAGEVKPVFEEFLSVWQDMSADDMFEHYAGVITRHYLDQPEPDVVFREEAHLRQQNIFHRSGFIELEVNRPVFMLDPLDPETVMVIYHQEYRSAILQDVGTKVFFFARQEDAAKEHPWKIKAEMWVKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPN6</accession>
    <name>D6SPN6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870030.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34712">
        <property type="protein sequence ID" value="EFI34712"/>
        <property type="gene ID" value="Dthio_PD2085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="149" mass="16711" checksum="D2D6BD203E7AC923" modified="2010-08-10" version="1">MRIYESEAEVLIWPYHGMKSPGHAALKIRTNKDGEVYQAYVSWWPAGGEGKNTPFSYRPAEAQPGYYKDKFLEMSASTRNRLNDGEINRDPRRFQKVSQNPNTALEFVTSANKKFNLPGLFSRVGRTRKSGAGIDGFDNVAGRSSLADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPP7</accession>
    <name>D6SPP7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV / VI secretion system, DotU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870041.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2096"/>
    <dbReference type="EnsemblBacteria" id="EFI34723">
        <property type="protein sequence ID" value="EFI34723"/>
        <property type="gene ID" value="Dthio_PD2096"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1612542at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DotU" evidence="2">
        <location>
            <begin position="60"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="242" mass="28023" checksum="1583304A5EC5EFE2" modified="2010-08-10" version="1">MKNNHWKDIHTLLVQRDQLFMPFLSSGEENREGFEFSDLHQDSQHNGWTLPGSSSQEPGIEDLVQVRASIRDELDRLRIALETDLNERDVYYILFPLVAHIDEQVQFRFLNPAQSNGWPPLQRELFDTDSAGELFYETLDDLLIKPQTLPLILEVYYYCLNEGFGGRLANNPSKRQEYMERLRNRIPTPSQQDETVPFPVEEVQSSSMLSTISPFWFYCSAAVATGLVYAGLKLLGHYWTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPY6</accession>
    <name>D6SPY6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870128.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2195"/>
    <dbReference type="EnsemblBacteria" id="EFI34812">
        <property type="protein sequence ID" value="EFI34812"/>
        <property type="gene ID" value="Dthio_PD2195"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="3">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="9012" checksum="ACB0DEDCCBCCC76F" modified="2010-08-10" version="1">MNTAMPQDPHFNKKYQQHLKCLKLGGLQPKTIDAYARAIRRIGNYFDGKVDDLSSEQLLDYFTKLLDTHSWSAVKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ00</accession>
    <name>D6SQ00_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870140.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34826">
        <property type="protein sequence ID" value="EFI34826"/>
        <property type="gene ID" value="Dthio_PD2214"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50317TY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="298" mass="33625" checksum="7F711B3BB964EAA8" modified="2010-08-10" version="1">MKIGSLEIDSRYLIIAGVILLLVVIFGVRQHANRQAQEVADGIISEVSDYVKVEYNSVRGEILGSAIVLNGVTVAPKSDPEQKSEIDRVQIQARDFSDNGVPYTMNASIEGLAIYIDDMKPDDARTMRDLGYEEVMRGNLQFGYKYDLDESHLSLHDIGIGIDDMGSISFDLDLGNITPDKRDLMNLLFTHQEILVGDFRLHYNDDSFIPRIIQYVADDTGMSEDEVLEMVIAKVEQDIRVADTNFARESLKNLKSFLENQDSLSITARPEEPRPLGRLMQIQNTDDIIEYMNISIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ24</accession>
    <name>D6SQ24_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2241"/>
    <dbReference type="EnsemblBacteria" id="EFI34850">
        <property type="protein sequence ID" value="EFI34850"/>
        <property type="gene ID" value="Dthio_PD2241"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZHY1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088145" evidence="2">
        <location>
            <begin position="21"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="275" mass="31580" checksum="8C8052D720EAF9D8" modified="2010-08-10" version="1">MWRKLLLSSLLLFAVSCAREEPVQNYFYLQDPGEEFYEQARFEVSLDPAEIDEFATLEKAFWEHGADKCFSINARKVINREPLVRPGRMGSPGSGTVFVRTSGEIEPVQASMTDAQSQEFTCMLSTIPHWSLAGEIVAFDKDKTIAATRDKIDVELFDRYPEKGPAYFFVARRTEREGRLLLKVFGSGKLQQVLQSDTQMKWHENPSGTLGRGIILETRREVRPGDLILLSYLSVEGVHEEDEPEYEEVQVQPRMRISPEEDEPTEDDPELWRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ27</accession>
    <name>D6SQ27_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cell division protein FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD2244</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870167.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2244"/>
    <dbReference type="EnsemblBacteria" id="EFI34853">
        <property type="protein sequence ID" value="EFI34853"/>
        <property type="gene ID" value="Dthio_PD2244"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="349533at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="13">
        <location>
            <begin position="369"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="709" mass="77709" checksum="B047FC7FCB1D2409" modified="2010-08-10" version="1">MDGSRLYREIPGTVMFFLALLLGVSLAGYSSLDPTFNQQVGSAHTVQNPAGTVGAYLGGSLVELLGVGSLVVPLFFVYLGLYLFWPVLQLAWWRWLGLFFCFAALIVWAEFPRVQAFTQDMEISGGGFAGSQLYQAGFEALGFWGILIAGGFLTLMGIQLATGFSWGGGLYRLAVLMPDKKERDRDSSSDSTGSARQAPKKQNSSSSGKGKKKADPHPPAPQASPGNIDTSRYDLPPLELLTSAPDDVLKVDQTRLDEIAQAVKSSLEDFSVQGEVQRVQPGPVVTMLEYKPAPGVKISRISNLHDDLALALKAAAVRIVAPLPGKDTVGVEIPNDNRQTVYLQEILESGDFGRSKHKLPLALGKDIQGRPRVEDLSRMPHLLVAGATGAGKSVCLNSLLLSLLFRYPPRELKFLLIDPKRIELAVYNDLPHLVHPVVTDMNLAKTALDWAIYEMEKRYDRMAALGVRNIEGYNQKLASFGDNPPEGFEDQESMPYLVIVVDEMADLMLTAGKEVEMGIVRLAQLARAAGIHLVLATQRPSVDVVTGIIKANFPSRIAFQVSSKHDSRTILDSVGAEYLLGHGDMLFKSAGGQMQRIHGAFVQEEEIASVVQFWKDKAGAEFELDFNEWKNSENGQNGQDFESDPVVDDPKYAQAVEFIQEQGKGSISLIQRRFRIGYNKAALFIEQMEKDGILGPSDGSRPRQVLKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ73</accession>
    <name>D6SQ73_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the rubredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870213.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2290"/>
    <dbReference type="EnsemblBacteria" id="EFI34899">
        <property type="protein sequence ID" value="EFI34899"/>
        <property type="gene ID" value="Dthio_PD2290"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047418at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="8">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="67" mass="7466" checksum="E43333ACA70529CD" modified="2010-08-10" version="1">MAQPEEMWQCQMTNCGCIYDPDKGDRKNKTPKGTAFEDLPEDWKCPVCGASTKNFRPLAGPGSAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ97</accession>
    <name>D6SQ97_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tfp pilus assembly protein PilO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870237.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2314"/>
    <dbReference type="EnsemblBacteria" id="EFI34923">
        <property type="protein sequence ID" value="EFI34923"/>
        <property type="gene ID" value="Dthio_PD2314"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1803493at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043107">
        <property type="term" value="P:type IV pilus-dependent motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007445">
        <property type="entry name" value="PilO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04350">
        <property type="entry name" value="PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="205" mass="23211" checksum="F8F60F69679ABEFB" modified="2010-08-10" version="1">MKLSREQIIAGVESLSTGRRILILVLLVVIVGGGSWQFFIGPNLQQARDLESELEDLETDIALYSGQVAELAKKEEEAEAMQKELEMAQTLLPADTHALERLLASFERLGNEKGVRFLLFQPGSEEMHDYFASRSVQLRLQGRFHDLVGYFDALAGLDRLVSLESLRLRPVDEQQFSRDRMLTAESRLRVYRALTAEEEAALEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQD3</accession>
    <name>D6SQD3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870273.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2351"/>
    <dbReference type="EnsemblBacteria" id="EFI34959">
        <property type="protein sequence ID" value="EFI34959"/>
        <property type="gene ID" value="Dthio_PD2351"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="248"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="37089" checksum="6792E0C8B16CD73C" modified="2010-08-10" version="1">MKTAIIGFSGSGKTELFKALAGPGTPGNRAAVKVPEPRLEPLCDLFKPKKITHTEIEFQDLPGGGSNSLGNKVLSDIRGFECLLAVLDAYTGTHDPAAQQSAIEAELIIADLAVIEKKLERMQEDKKKAKHLHDQNQEELLNKARQVLEQDSPLREYPDLAAHEDLRGFAFLSSRPVLYAWNVAEDSLSGFKTPPESTGMGHVAFSARLERELSELEDQQELLEFMQELGIEGSVLDRVIGRTYDLLGLITFLTAGEKEVRSWPLKRGKNAWEAAGVIHSDIQKGFIRAEVLGWEDFLACKTFKKAREQGVLRLEGKEYIVRDGDIITFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQI6</accession>
    <name>D6SQI6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intracellular protease, PfpI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870326.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2405"/>
    <dbReference type="MEROPS" id="C56.001"/>
    <dbReference type="EnsemblBacteria" id="EFI35012">
        <property type="protein sequence ID" value="EFI35012"/>
        <property type="gene ID" value="Dthio_PD2405"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="174" mass="19204" checksum="AEAC6AE0543FE8BA" modified="2010-08-10" version="1">MELKGRKTMVMVEQMYNDYEFVYPYYRLLEAGAHVDVVAPEAKKTYPGKGGTTATSSLAAKDAVPGDYAGIVIPGGFAPDFMRRHEAMVNLVREMFNQGKVVAAICHGGWMLASARILQDKKVTSFFAIKDDLIHAGANWVDEEVVVDKNLITSRTPDDLPAFMRAALEGMSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQJ9</accession>
    <name>D6SQJ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870339.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2419"/>
    <dbReference type="EnsemblBacteria" id="EFI35025">
        <property type="protein sequence ID" value="EFI35025"/>
        <property type="gene ID" value="Dthio_PD2419"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="3">
        <location>
            <begin position="199"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="556" mass="59876" checksum="9185CC04ABDC3B92" modified="2010-08-10" version="1">MRRELNILIGGEAGQGLVTVGELLTRALIRSGYQVHVTQSYMSRIRGGHNTYAVRAGIENVHGPAQGIDILVALNSETLELHREELTPGAVALKDKNAQASDLEAVDIPFADLAGSALYENVVGLGVLSYILGLDREMPAGCIRSAFEQKKPEAVDKNLEVLDKAYAFASKSGVAGFNLDEPKGSAGLMLAGNQALALGALCAGANFCSYYPMTPSTGIPMTLNSYARDFGMVVEQAEDEIAAINMALGASYAGARSMVATSGGGFALMCEGVSLSGMTETPVVIVVGQRPGPATGLPTRTEQGDLNLVLYSGHGEFPRAVLAPADPGQCFVLARRAFDLAEKSQGPVFILTDQYLADSYRNVHLPDPEILEPVASPEVCGEVQEEYERYAFTPSGVSPRIIPAMSRCLVVLDSDEHTPDGHITEDLQVRKKMVDKRLKKGDILKQEVILPAYTGPQNPKDLLVCWGSTRGPALEAREIMGSENTAVLHFSQVWPLDAEHFRDYLQRAQRVVFVESNATAQFAQLVSSMVQPANMAYVLRYDGLPLDGQYIADNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQM6</accession>
    <name>D6SQM6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c-type biogenesis protein CcmE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870366.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2446"/>
    <dbReference type="EnsemblBacteria" id="EFI35052">
        <property type="protein sequence ID" value="EFI35052"/>
        <property type="gene ID" value="Dthio_PD2446"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724595at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017003">
        <property type="term" value="P:protein-heme linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004329">
        <property type="entry name" value="CcmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036127">
        <property type="entry name" value="CcmE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03100">
        <property type="entry name" value="CcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82093">
        <property type="entry name" value="SSF82093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="15199" checksum="55FEB57612E9218F" modified="2010-08-10" version="1">MSTQKKSKFMYLAAFLLIFSGVGYLVVTSVTQSSTYFLEVSEALAMDQDKLDRARLFGKVAEEELERDSDALGVTFMLQDKDDKDKVIRVRYAGAVPDAFRPGAGVIVEGQARPEEGIFMAHDLMTQCPSRYESKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQU6</accession>
    <name>D6SQU6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870436.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2516"/>
    <dbReference type="EnsemblBacteria" id="EFI35122">
        <property type="protein sequence ID" value="EFI35122"/>
        <property type="gene ID" value="Dthio_PD2516"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="161" mass="17797" checksum="3E8DEECD0F87B9F4" modified="2010-08-10" version="1">MVDLSFVKPLFLPDEEATLELGRKLGLFFTSRGFFPAVFFCGELGTGKTTMIRGIVSALPGGDEAEVSSPSFNLANIYPTRPETLHVDLYRLQGLEPDQDVEELLAGQERLILLEWGDFLPESQRPRDRVDISLKFCNGSREALITLSGEGEKLRSSSICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR03</accession>
    <name>D6SR03_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytotoxic translational repressor of toxin-antitoxin stability system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2577"/>
    <dbReference type="EnsemblBacteria" id="EFI35179">
        <property type="protein sequence ID" value="EFI35179"/>
        <property type="gene ID" value="Dthio_PD2577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="57" mass="6694" checksum="4FD8A69C7093E1E7" modified="2010-08-10" version="1">MNKYGVKYHPAVKSEDLPRLGSDIKSWIRRTIEEKLTQAPQEYGLTLYRSAGRNWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRA4</accession>
    <name>D6SRA4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1722 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870578.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0546"/>
    <dbReference type="EnsemblBacteria" id="EFI33220">
        <property type="protein sequence ID" value="EFI33220"/>
        <property type="gene ID" value="Dthio_PD0546"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1757306at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013560">
        <property type="entry name" value="DUF1722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017087">
        <property type="entry name" value="UCP037004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08349">
        <property type="entry name" value="DUF1722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037004">
        <property type="entry name" value="UCP037004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1722" evidence="1">
        <location>
            <begin position="187"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="312" mass="35876" checksum="B15B95D5A1EA21DC" modified="2010-08-10" version="1">MKIGISTCLLGENVRYDGGHKLDRYLRDLLGKYVSYVPVCPETESGMPIPREALRLVGDIDSPRLVTQKSGEDYTSVMQSWASKRLDALEKEKLCGFIFKSKSPSSGMERVKVYNDKGHPVPKGRGIFAGMFMERFPLLPVEEEGRLHDPMLRENFITRIFVYGRWLELMEQGLTTARLIDFHTRHKLLLMAHNVNAYRELGRLVAGARELPPDELADQYISKLMTALKLSSTIKKNVNVLQHVMGYFKKDLSSDEKQELLEVIGNYKDSLVPLIVPVTLLNHYVRKYDQPYLKEQVYLNPHPMELKLRNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRG9</accession>
    <name>D6SRG9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33285">
        <property type="protein sequence ID" value="EFI33285"/>
        <property type="gene ID" value="Dthio_PD0611"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="715" mass="82128" checksum="FA53A05C66CFA3A4" modified="2010-08-10" version="1">MIRQHPFVMYILELQYDNAALNEQGVFSLSGSHETPGRWNVIEKSHAPLQEELLRLVALSCSGCTAFLNRLDFDLKSLVETRKKNLHLELCWRSHIPQNRTVFASGPVKSAVAITKKGAPRRLGREKARLLPDKYPYLKLSKWCPPSRHTVFAYGSGINLSNADHDFDFHDPFFQLKRIHSLFDSRAGLTHAPSFLASLHYRAVRCRRYMPASILGDLQRFFAACFGLQTSAWMQKDADIAALWEQVPAHLKLPLLPVMDAARHLHDALPSQPNPLHFPGVMILDSPEKYCPQDYFPDWIKLLEQVFPAMQFIVALSPLAYQNFYKNFSWGTLPQFKDYHQHYPPRTTPSAPSSPLSPGTMLMVDVDGRLPNLALMKLARHYREKGYPVQLARKEACVPDAEAVFASCVFNLDSSRRRFFKMQSFYGQKFCGGGSGVDLHMRLPADIEAKDPDFDLYPELQERALGFLTRGCPFKCPFCIVPVKEGRPRQVSDVKSLVQGRKKLILLDDNILAHPECEKLLQELAARKIAVNFNQTLDLSLVDESRAGLLRRIQACNVNFKRSVYHFSLNDDSNLQALRRKYELLAFNSKNNVEFICMYGYNTTLAQDLERFKFLRSLPGAYVFVQQYQPILNGPPPQMENYFDGQADRYIDELIRICFPQCMKSMEKYYRWLSKRYVEAFGTLHMGLVDTIFRYNNRFNRGKYIASLAGTRKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRI5</accession>
    <name>D6SRI5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0627"/>
    <dbReference type="EnsemblBacteria" id="EFI33301">
        <property type="protein sequence ID" value="EFI33301"/>
        <property type="gene ID" value="Dthio_PD0627"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="217" mass="24811" checksum="35D5C63F16A1F15B" modified="2010-08-10" version="1">MVKAMQYGNKSEHTRSKCIKCGQCCRRNSPALHQEDLPLITGKSLGRNTLILYRRGEPALDNVMGTPVLLGREMIKIRSANAGHRGCLFLDQHSGHCSIYGSRPMECSLLECWNPDPLMNYYQKNRLTRADIFPKGSAMDELICMHEEKCPVTELSYMLQQEVNAPGTLREEINSLLAFDDSFRQGFQEKTGAHEEDMLFYFGRPLKELVRPLMDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRQ4</accession>
    <name>D6SRQ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870728.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0699"/>
    <dbReference type="EnsemblBacteria" id="EFI33370">
        <property type="protein sequence ID" value="EFI33370"/>
        <property type="gene ID" value="Dthio_PD0699"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="35"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="183"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="402" mass="45943" checksum="D6002C5A0E8D038A" modified="2010-08-10" version="1">MHDHASRQQHNMSQTVIPRAIDLHRITRLMEIFPVTAILGARQCGKTTMAGFFHADHLFDLENPRDMARLETPQLALEELTGLVVIDEIQRLPDLFPLLRHLVDTIPDQKYLILGSASRELLRQGSESLAGRMGLYHLGCLHTLDVTSSSDLWLRGGYPRALLAKDDFSAFLWLENYITAFLEQDIPALGIVIPARTLRRFWSMLSHYHGQLLNYSELSTSFGISDMTARKYLDILAGTFMVRTLQPWHPNVSKRLVKRPKLYIRDSGLFHSLMGIDSMDTLLGHPKLGASWEGFALENVCFCLGKHDQELAFYRTHGGAELDLFWKHGGRNWGVEFKFADAPRKTKSMDVVRKDLDLAHLWVVYPGRDRYRLSEDITVLPLRDIRAGWEYSIVHTLCHAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRR6</accession>
    <name>D6SRR6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870740.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0713"/>
    <dbReference type="EnsemblBacteria" id="EFI33382">
        <property type="protein sequence ID" value="EFI33382"/>
        <property type="gene ID" value="Dthio_PD0713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="147" mass="16389" checksum="E67CF4A0F5C77985" modified="2010-08-10" version="1">MNKKSRGFTLLEVIAVLVVGGIVAALLVPFMSSAVVDSHKPLDNLRSSSGVSSEMVKVIANFKPNWNPVPPPCDGLEGKIEDFVEDKEENEEEWNAEFADDSPRICGFDDNFLECDSDPLPTDRVLEVTLQDKDNPGFRFTYYFPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRS8</accession>
    <name>D6SRS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0725"/>
    <dbReference type="EnsemblBacteria" id="EFI33394">
        <property type="protein sequence ID" value="EFI33394"/>
        <property type="gene ID" value="Dthio_PD0725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="65" mass="7931" checksum="13398E6F1DE7F4FF" modified="2010-08-10" version="1">MKKFEENYQRMIDDRRSFDIRFWQSQGDVAIFKAVTEMHNDYLLIRGKNADESRLQRTVETFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRW4</accession>
    <name>D6SRW4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Post-segregation antitoxin CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870782.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33430">
        <property type="protein sequence ID" value="EFI33430"/>
        <property type="gene ID" value="Dthio_PD0764"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2031872at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009956">
        <property type="entry name" value="Post-segregation_anti-tox_CcdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07362">
        <property type="entry name" value="CcdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="9115" checksum="96DE30ABD0632FD7" modified="2010-08-10" version="1">MENTTRKQPVNLRLRGDLLHKARSSNINLSQTLEQSLQKILKEQDRLTWMKENREAMEAANRYVDEHGLWSDGSRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRW5</accession>
    <name>D6SRW5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870783.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33431">
        <property type="protein sequence ID" value="EFI33431"/>
        <property type="gene ID" value="Dthio_PD0765"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="9810" checksum="772F00308513F28B" modified="2010-08-10" version="1">MALESKVTSKGQVTIPRDIRDSMGIGSAGRVSFTDLGNGLVLIRSCDKPASEIFGMLSDKPRTRKDALSIEEMNEVIKEQRLEAGSRGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS58</accession>
    <name>D6SS58_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein, family 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870874.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0858"/>
    <dbReference type="EnsemblBacteria" id="EFI33524">
        <property type="protein sequence ID" value="EFI33524"/>
        <property type="gene ID" value="Dthio_PD0858"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088170" evidence="2">
        <location>
            <begin position="26"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="359" mass="40056" checksum="0FD67B56FACD8221" modified="2010-08-10" version="1">MKTKSAFFSSLFILACVSLMFACSAENGQDVGEAPHEPIELSMVTFWPASHPQVEKGHNSWIEEVETRTQGRVKINLHAGESLLGAREIFSGVEDGVADIGSTCPAYTPGMFPLTEVFELPGYRNANSIAASLTVHEGYKKFKEDLEVDEFSSVKVLMFWATGPGDIMSKIPVETLEDMQRLEMRAAGGSAVPVKTLGAVPHSMPMSEAYLALDQGLVNSILGPTDTMKGFRLAEVVQYVTRTPFLYNIPFVKVMNQDAWNSLPEDVQDIFEELNEEFVIKYGQIFADASREGLQFARDEHGIEVIELSGEEEDRWIERLDMVVDDWIEEKKARGLPAEEAVSITRELDEKFSSEYGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSA3</accession>
    <name>D6SSA3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0903"/>
    <dbReference type="EnsemblBacteria" id="EFI33569">
        <property type="protein sequence ID" value="EFI33569"/>
        <property type="gene ID" value="Dthio_PD0903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="11643" checksum="EF663A4D49198DA4" modified="2010-08-10" version="1">MDSLTTFHLCDHARQEMQRRGIEYEVVVEVLANPEQVLTINSRRKVYQSRMVTEHTNRQYLYRIFVDFDRNPPVIVTAYRTGKITKYWRQQHENNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSF1</accession>
    <name>D6SSF1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OstA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0952"/>
    <dbReference type="EnsemblBacteria" id="EFI33617">
        <property type="protein sequence ID" value="EFI33617"/>
        <property type="gene ID" value="Dthio_PD0952"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088184" evidence="1">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="176" mass="19978" checksum="80A6C7B245AAE02F" modified="2010-08-10" version="1">MHCRFFPYILVCVLAALFLYPAGIQAENDKGTEITSRDMTFKGAENLIVFSGDVYVRRPDFELWSDKLYVYLRSDADMDETAPEAGEDDDIEKIVARGQVRIQGEGREGRSGLLTYYPDTEIVELEQDPRLIEGKNSVEGEKIVLNLKDNTSRVYGSEERRVRVIFHSDDSDGDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSF2</accession>
    <name>D6SSF2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870968.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0953"/>
    <dbReference type="EnsemblBacteria" id="EFI33618">
        <property type="protein sequence ID" value="EFI33618"/>
        <property type="gene ID" value="Dthio_PD0953"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="240" mass="26607" checksum="A6671E1A99B0D7E0" modified="2010-08-10" version="1">MSTLQALDVYKQYGKKPVVKGISLDINRGEIVGLLGPNGAGKTTTFYMLVGIIPPTKGRVALAGQDITGLSLPKRAELGMSYLPQESSIFKKLSVYDNLMLILEYTCRDRKLRREKAESLMHELGISKLAHQKASFLSGGERRRLEIARSLIKDPEFILLDEPFAGIDPIAVDDIQKIVLKLKEKNIGVLISDHNVRETLKICDRASLVFEGQVILNGTPGEIAQDARARQVYLGESFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSH7</accession>
    <name>D6SSH7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870992.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0978"/>
    <dbReference type="EnsemblBacteria" id="EFI33643">
        <property type="protein sequence ID" value="EFI33643"/>
        <property type="gene ID" value="Dthio_PD0978"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="278"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="522"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="645" mass="72518" checksum="B42309344DD9B020" modified="2010-08-10" version="1">MQQEFHQARIMIVDDTPANLNLLMDMLLKKGHQVVAFPSGQQALEAASKTPPDLILLDIRMPGMDGFEVCRKLKQDPDLQDIPVIFISALQDVSDKVQAYNTGGVDYVSKPFQPEEVYARVETHLRLNRLLRESEESRRVLIEELPDIIVRFDRQARHVSVSDNIRDLGITEPGEYIGRTHRELGYSESCCRFWEKSIATVFDSGEPLEEEMSLYSGDNEGLIHNVRMVPERDSSGNIVTVLAISRDITLQKQAQQALLNAKKDAEAANQSKNEFLANMSHEIRTPLNGIEGMMQMLLSTPLNSEQQKFIEMGHQASRRMTELLSDILDLSRLEAGREDVSKRTFNLKDVCDSLWDLLGIKSREKGIPLTFNLSPSLPDTLMGDSTMVRQILFNLVGNALKFTEHGQVTLDIHPLPQSHQDQLQVLFTVSDTGPGIPDDKQDRIFKPFDMVNGSLTRKHEGKGLGLTVTHRLAKLMGGTISVDSAEGQGTSIYVTLPFETVPETRPAENERVNEYEKPAGMRILIAEDDSLSRIFFEKILQGEGHRVESVEHGDQVMSRLAMNDYDCILMDIELPGIRGDEITTRIRAADNLGAKKDIPIFAVTAYTQPGDREHFLKAGMDDYLPKPLGIQEFREAFKKHGLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSJ7</accession>
    <name>D6SSJ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfite reductase, dissimilatory-type beta subunit</fullName>
            <ecNumber evidence="6">1.8.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.99.3" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871012.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0999"/>
    <dbReference type="EnsemblBacteria" id="EFI33663">
        <property type="protein sequence ID" value="EFI33663"/>
        <property type="gene ID" value="Dthio_PD0999"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018551">
        <property type="term" value="F:hydrogensulfite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011808">
        <property type="entry name" value="DsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02066">
        <property type="entry name" value="dsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="387" mass="43707" checksum="5283FA0A8A69EBF7" modified="2010-08-10" version="1">MAFISSGYNPDKPMEDRITDIGPRHYSEFLPPVIKNNKGKWLWHEILEPGVLMHKAESGDEVYTVRCGSPRLMGTETLREALEIADKHCDGYLRFTTRNNIEFMVDSKDKVQPLKDDLQSRKHEGGSYKFPVGGTGAGLTNIVHTQGWIHCHTPASDASGTVKVVMDELFEEFQQMRFPAQLRISMACCLNMCGAVHCSDIAILGYHRKPPIIDHKEVENLCEIPLAVAACPTAAIRPAKTTITDDRTGEEKTVKTVAIKNERCMFCGNCYTMCPALPLTDAEGDGLVIMAGGKVSNRISEPKFSKVVVAFIPNETPRWPSLAKCMRQLVDAYVKGAKKYERFGDWAERIGWERFFEVTGLEFTHHLIDDFRDPAYYTWRQTTNFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSJ8</accession>
    <name>D6SSJ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfite reductase, dissimilatory-type alpha subunit</fullName>
            <ecNumber evidence="5">1.8.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.99.3" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871013.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1000"/>
    <dbReference type="EnsemblBacteria" id="EFI33664">
        <property type="protein sequence ID" value="EFI33664"/>
        <property type="gene ID" value="Dthio_PD1000"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018551">
        <property type="term" value="F:hydrogensulfite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011806">
        <property type="entry name" value="DsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02064">
        <property type="entry name" value="dsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="437" mass="49625" checksum="F9AA4BDE1DD436EB" modified="2010-08-10" version="1">MPKHETPLLDQLESGAWPSFVADLKRQAGSRQQKQNEIEFQIPVDVVDDLLGLLELSYVEKEVHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTMRVNQPAGKYYKTDYLRQLCDLWDFRGSGLTNMHGSTGDIVLLGTTTPQLEEIFYELTHKMDQDLGGSGSNLRTPAACLGESRCEWACYDTQELCYQMTMEYQDELHRPAFPYKFKFKFDGCPNGCVASIARADMSFIGTWRDDIRIDQEAVAAYVGGEIKPNGGAHAGKDWGPFDIQKEVIDLCPTKCMWMEGGKLNINDRECTRCMHCINVMPRALRIGNDRGLSILCGAKAPILDGAQLGSLLVPFMKVDESYDGVKEVIENIWDWWMEEGKNRERLGETMKRQGFQKLLEVTGIDPDPRHVSEPRHNPYIFWKEEEVPGGFERDINDYRSRHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSP8</accession>
    <name>D6SSP8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871063.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1053"/>
    <dbReference type="EnsemblBacteria" id="EFI33714">
        <property type="protein sequence ID" value="EFI33714"/>
        <property type="gene ID" value="Dthio_PD1053"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033B8E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065963at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="110" mass="11906" checksum="8BD12D17F0CDA436" modified="2010-08-10" version="1">MAKTCIFVLAVILMGGVLIMGCSEAPEVPGVYQEVSENGPDAGSTIELQEDRKGTWETPRDSVSFRWSVREGEIWLHTETGGVIIGELSDSGFVIELPEAGTYVFEKTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSS3</accession>
    <name>D6SSS3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chemotaxis protein methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871088.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1078"/>
    <dbReference type="EnsemblBacteria" id="EFI33739">
        <property type="protein sequence ID" value="EFI33739"/>
        <property type="gene ID" value="Dthio_PD1078"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000410-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="288" mass="34169" checksum="F7FB1484AC86F8E2" modified="2010-08-10" version="1">MNHNDNLKNGQWSLPRPMTVQEFKKLGHFIQTEFGIKMPPSKKTMLESRLSKRLRSLNMTNFEEYRDYLFSLKGLELEMPHLVDAVTTNKTDFFREEHHFDILYKELLPEWMERYPEGGRIMAWCAGCSNGKEPYTLAMVLNEFGIEHPVFDYNILATDISRQVLKEAERAVYPVKDAEAIPPVLRKKYLLRSRDRNRQLIRIVPELRKRVAFREMNLLQDISFREKMDIIFCRNVIIYFERPVQEALFRKLCKFLEPGGYLFIGHSETLNGMDLPLKQTRPTVYRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST38</accession>
    <name>D6ST38_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871203.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1193"/>
    <dbReference type="EnsemblBacteria" id="EFI33854">
        <property type="protein sequence ID" value="EFI33854"/>
        <property type="gene ID" value="Dthio_PD1193"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="150"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="465" mass="52571" checksum="5037950CECEE8F09" modified="2010-08-10" version="1">MNQVQIKNSKLLIVEDDKGLGQLLTEEVQDNGLEAFWCSSAEEALSMMNSWNPDLVVSDLRLPGMDGLEFLQKVRDNFPDNQPDFLVITAFGTISRAVETLKAGAEDFLTKPLDLDHFILTVERVLRNRALRLEVKQIKSLLNSDSFHDMYGQSRCMRFLFDQITRVAQADGPVLILGESGTGKELVARAIHGESKRAQNPFLAVNCAGIPEHLLESEFFGHKAGAFTGASKTRQGLFAEAHGGTLLLDEISEMPLFMQAKLLRLLQDGKVRPVGGNQEEQVDVRILAATHRDLEEEVRHGHFREDLFYRLETFTLRIPPLRERETDLELLAERLLRRFCVQTGKKIQGFSQQALNILEKYHFPGNVRELQNAVERAVTFCDGNEILPRHLPARIRDNQSSSQESQAHVSQQLFQDQNLPPLSEVEQRYIQHVLDKVGGNKRRAASILGIGRRTLYRRLGEEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST67</accession>
    <name>D6ST67_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871232.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1222"/>
    <dbReference type="EnsemblBacteria" id="EFI33883">
        <property type="protein sequence ID" value="EFI33883"/>
        <property type="gene ID" value="Dthio_PD1222"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="195" mass="22426" checksum="727367B6ACA2A46F" modified="2010-08-10" version="1">MEEAIAAFGQNYWLIFISSLFLAPEAVLFVTAAMADQPLLTVFLIIVLVSIGGSIGSVCIYFLSMLLGRERLFYLAGRAQRYYLVKVDDLEQVFDFFERKGHWVVFFGRMAPTIRSLVSVPPGIIRMPFRRFLIYTFMGTFVWNVFVGYAFYFFWMHAEAINKLLGLYAAICLGAVILFVFWLVGRNIVKRMMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST98</accession>
    <name>D6ST98_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease, Rne/Rng family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871263.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1253"/>
    <dbReference type="EnsemblBacteria" id="EFI33914">
        <property type="protein sequence ID" value="EFI33914"/>
        <property type="gene ID" value="Dthio_PD1253"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1209444at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="46"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="488" mass="56000" checksum="AC49E6DFADD71AA5" modified="2010-08-10" version="1">MSNAQKRKRKMFLSVLPGEQIELVLALDGVIQEYYVEMLGQIKTKGNIYKGKIHNIDQALQAAFINYGTGKNGFLQVDEVHPEYYQAEVKPGKGHKYPPLQKVLKPGQELLVQVVKEPTGNKGAFLTTYLSLPGRYFVLTPGREQLGISRKIEDEKERERLKGIVQELKLDEGLGVIVRTVSEGQNKTSLSRDLQFLKRLWKEVRKKGVAEKTPALIYEEKDLAFRAARDYLTEDVSEIWVDNEEVAQQVQEFVNLIFPRRKKMVRIHSDPEKTLMERFNLEKQISQIFSREVELPSGGRLVFDQTEALMAVDINSGKIGGEKDFREMAFKTNLEAAENIPRQLMLRDVGGQIVIDFIEMRDKKHISQVEKALRAALKSDKARTDVSRISRFGLIQLVRQRLGISALSVIMESCRHCQGTGTIRNLEWQALQAQKEIYRLLRRKSCPSPLEFPVDQDLAVYLLNHKRDKLVHMEQQFDNQVLITPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6STA1</accession>
    <name>D6STA1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.70" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1256"/>
    <dbReference type="EnsemblBacteria" id="EFI33917">
        <property type="protein sequence ID" value="EFI33917"/>
        <property type="gene ID" value="Dthio_PD1256"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="6">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="159" mass="17497" checksum="5F7F28AAFD986557" modified="2010-08-10" version="1">MNSTNKIITAPDFAEKRHSLLRQKIVFTNGCFDLLHAGHVDYLEKARSLGDLLVVGVNSDSSVKRIKPGLDRPVNTETDRARVLAGLGCVDQVIIFGEDTPYSLIEKVRPNILVKGGDWPVEKIVGRDIVQGLGGEVLSIPFIRDCSTTGILERIKRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STC2</accession>
    <name>D6STC2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871287.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1277"/>
    <dbReference type="EnsemblBacteria" id="EFI33938">
        <property type="protein sequence ID" value="EFI33938"/>
        <property type="gene ID" value="Dthio_PD1277"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50343G9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2080206at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="14313" checksum="605A79D31BC899E1" modified="2010-08-10" version="1">MFRPTSKELSDRLKKAEKAVFDGRVSIIDPETAAEHAIELEYDIELDLQEVLKELLSQISRDEYAGTRPPQKSYKEEIKGLEIFPFVLDSPRFACRVYLKFALQQETFWLISLHKDRPPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6STJ3</accession>
    <name>D6STJ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871358.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1348"/>
    <dbReference type="EnsemblBacteria" id="EFI34009">
        <property type="protein sequence ID" value="EFI34009"/>
        <property type="gene ID" value="Dthio_PD1348"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="136"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="473" mass="52638" checksum="29AEAFFFEA97B810" modified="2010-08-10" version="1">MSSKRILFIARSELISPVLSRLRQEGYELLMSESLEGALKIISQKSPALIFSQVAMPGFRIHDLLDALESQEMQRRVIAVAEQGTAREAQQILEAGAGDYWLAPLQWDKVKAVLPGSSPQQAQNRTSVSEPGKHEIIGSHPAMQKVMALARQVASSKASVLISGESGTGKEMFARFLHNNSPRHAGPFVAVNCAALPEHLLESELFGHEKGAFTGAISRKVGKFELAHQGTILLDEISEMDLALQAKLLRVLQESEIDRVGGTDTVRVDVRVLATTNRNIEECARRGEFRQDLFYRLNVIPLRLPPLRERKDDILVLAGHFIRHYSTQYGLPAMEPDEEAAGWLVEYDWPGNVRELQNLMERAVLLAGQSGVIRTRHFLLEEDDLQDILEESQGNHAEEESLPFTQDDAAVAAIDPGGDDEIYPIHEMEKRMIMKSLKKTGGNRTQASELLGISVRTLRNKLSEYKKQGLVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6STT7</accession>
    <name>D6STT7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871452.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1443"/>
    <dbReference type="EnsemblBacteria" id="EFI34103">
        <property type="protein sequence ID" value="EFI34103"/>
        <property type="gene ID" value="Dthio_PD1443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="7147" checksum="A6A20D78A09229CD" modified="2010-08-10" version="1">MPSSRAKYNAYNKLLVDIMKSELPLETKREITHAMSQENILNGTAKGKQLFKQAKKANKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6STU3</accession>
    <name>D6STU3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871458.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1450"/>
    <dbReference type="EnsemblBacteria" id="EFI34109">
        <property type="protein sequence ID" value="EFI34109"/>
        <property type="gene ID" value="Dthio_PD1450"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024399">
        <property type="entry name" value="DUF2628"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10947">
        <property type="entry name" value="DUF2628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="611" mass="68779" checksum="FD6DF99ADEB396BE" modified="2010-08-10" version="1">MKSFDVYHSSAKGLRLIKSGFSWPAFFLNFIWLFYAGLWDFAIAFLCWILFGAYLLVAVEPVQENIYLLASLCGVYFIIILLPGLYGNRWLKNKLVLDRFELVQAIQAKSRKDAYSRLQSLNPDLYARHQLFRYAQQENDDTDSPRIGRSITVHRVSSGFSHRRKILVGFSILLSLTLSWTIVQHESSTQKNPVADESLKEKPLSQEEADHVHQPENKEYSAEKITSLSKEAKQLQDEDLQMDSEVFSKEMDTAHTDSDSAQKIAEQCRKESHVGQWEEAVELCRQSVSENPQDAGSWEQLGRSYMHTDQPGEAAKAFEKAGNIDASKGLDGFELLAEKEPDKAQAWVGMGRAYMEMDDTDQALQAFDKAAALDPEKGREGLEKVVQEKPENARAWKGLGRSYLETEQPEQAVLAFEKASQSDMQLGMAELQAVVRKYPNNASALKKLGSIYRKAGRTEMAVDHLEDAVNKNSGSASAWFELGKALHELSQATSTDSHSGPQVVTFYHELLDVWQVFEGFRVCSLHLEAMQAYQHAVLLHPGYAIAWRELGSFFLQQGGWTKPAVFYLKNAVKANPMDVDAWEALNVAYRASGQKSRASYALHRAGHLSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6STV1</accession>
    <name>D6STV1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871466.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1458"/>
    <dbReference type="EnsemblBacteria" id="EFI34117">
        <property type="protein sequence ID" value="EFI34117"/>
        <property type="gene ID" value="Dthio_PD1458"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9AI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="979422at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026483">
        <property type="entry name" value="Cas_Csx17"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04113">
        <property type="entry name" value="cas_csx17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="779" mass="87343" checksum="5C8096521F329128" modified="2010-08-10" version="1">MNEFKLPGCTTRPLSGYLKALAVFRLISEQKDHEALGCWDQGTFKIRTTLAPDDILSFFCNEYVPTPIITPWNGGSGFYPGDSRQGIDSILQTNDPRFAGYKQAITSVFNWPEWAEQMNTGQELLDVLETMIKNSSPGKKQQDLVKLKDAVLKEAESVKNKTSEDPLLLALERIEALSSQEPGLYRCLWNSIKKARTKYNDHVRQKTKDIIVPICRSRLPDNCLPWLDALCAIHADGSRTPHRILGTYGNDGRLEFGNNFMRIISSLLLDGNGSTAKDYLAASLWNQPVKGLPKVKAGQFDPGRAGGYNQGMGVEAKDFKANPWDYVLTLEGTLVLASSVVRRQGGNAGSRLTGPFTVHFSPVGFTSSEYTEPEGGETEIWLPLWGQFASFTEVRHLFSEGRSSVGRRQAGTGLEFSRAVGTLGVDRGISAFERYGFLKRRGDNKIALPAGKIPVRFKPQLEIFSELDPVLSRVDQFMLSFKKAPASYLQARQQIDEDLFNCTLQPDSLNYLKLIRSIGRLEKLLALRDRNKDPKLQQPLYGLSPRWVFQADDGSPEIRIAAAIASIQGTDRLGPIRSNMAGVSARTPWQWAEFSSDQHWFGSDFSERIGNLLSYRLMDAERKQAASMPFQGLIAVSPYDLMPFLHEETDDAKMEELLWGVTLIDWKKSGLIKIQKAWKYPVARSIISRTWCLLKLLHVPGDVRGVKIRRERSVSSLLNAGRVEEACAKAVQRLKISDLRPFPVRYNEPLSPARLLASLIVPIKNQNLLEEMVLQMPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6STW1</accession>
    <name>D6STW1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly PilZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871476.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1469"/>
    <dbReference type="EnsemblBacteria" id="EFI34127">
        <property type="protein sequence ID" value="EFI34127"/>
        <property type="gene ID" value="Dthio_PD1469"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ECA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2003700at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15035" checksum="75891B686CCA0D57" modified="2010-08-10" version="1">MPDQDMRKRSRVELQLSVSIQQNDVHGLLKTSNLSLKGLLADYHPDFTVNEPCELVIHLSSGLEIGITGIVVYSSPERGTAVDFVQMDEESFYHLLNVVRLYSTDPDQVERELLTPAFDSSTLEQLKNSYRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU04</accession>
    <name>D6SU04_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871787.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0410"/>
    <dbReference type="EnsemblBacteria" id="EFI33095">
        <property type="protein sequence ID" value="EFI33095"/>
        <property type="gene ID" value="Dthio_PD0410"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y1Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1986424at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="8175" checksum="61401AEA7128149F" modified="2010-08-10" version="1">MLKITKHIVYDEYHNPVAIQIPIQEFEYLEEIIENHGLARLMEEAADEEKLSVNEAKDYYQSLKQHVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU32</accession>
    <name>D6SU32_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33123">
        <property type="protein sequence ID" value="EFI33123"/>
        <property type="gene ID" value="Dthio_PD0438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="35" mass="4042" checksum="3A55FB07B81216FE" modified="2010-08-10" version="1">MTTADCLVLKEEVMFVEILALAVIMFVIYIAFFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU95</accession>
    <name>D6SU95_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871569.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0188"/>
    <dbReference type="EnsemblBacteria" id="EFI32875">
        <property type="protein sequence ID" value="EFI32875"/>
        <property type="gene ID" value="Dthio_PD0188"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2031541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9995" checksum="C6023F2310265C44" modified="2010-08-10" version="1">MSIRLELDNDLQDALRIPPEEQESRLRRELSLRLYEKGLLSLGKARHMAGMDKWEFLLLLSREGIPRQYDTKELDRDLSTLDSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUB3</accession>
    <name>D6SUB3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="11" type="ORF">Dthio_PD0207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871586.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0207"/>
    <dbReference type="EnsemblBacteria" id="EFI32893">
        <property type="protein sequence ID" value="EFI32893"/>
        <property type="gene ID" value="Dthio_PD0207"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="166"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI32893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="415" mass="46325" checksum="3F938981CDA719B6" modified="2010-08-10" version="1">MNLSDLKTKSMKELMQLSKEYEIENPSGMRKQELIFAILQSCASQNGTVSGEGVLEILPDGFGFLRSPMYSYMPGPDDIYVSPSQIRKFGLRTGDVVSGQIRPPKEGERYFALLRVNQVGFGEPSESKSLVLFDNLTPIYPDKRFVLENGAENLSSRVLDLLSPVGTGQRGLIVAPPRTGKTVLLQSIANSINANDPDVFMIVLLIDERPEEVTDMERTVDAEVVSSTFDEPPQRHVQVAEMVLEKAKRLVERKKDVVILLDSITRLGRAYNTITPSSGRVLSGGLDSNALQRPKRFFGAARNIEEGGSLTIIATALIDTGSRMDEVIFEEFKGTGNMEIYLDRHLADKRVFPAIDINRSGTRKEDLLLSEDVLNKVWILRKVLAPMNSVDSMEFLLDKMKGTKSNREFLDMMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUD0</accession>
    <name>D6SUD0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracellular solute-binding protein family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0224"/>
    <dbReference type="EnsemblBacteria" id="EFI32910">
        <property type="protein sequence ID" value="EFI32910"/>
        <property type="gene ID" value="Dthio_PD0224"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00994">
        <property type="entry name" value="PBP2_GlnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044132">
        <property type="entry name" value="PBP2_GlnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087959" evidence="4">
        <location>
            <begin position="28"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="6">
        <location>
            <begin position="29"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="253" mass="27918" checksum="99590783158E9886" modified="2010-08-10" version="1">MKRSGFFLCLLLGVFMFMSMFASSLHAKKLTVAVDTAFVPFEFRDSDTGEYVGFDIDLWDAIADRLGVEYELQPMDFSGIVPALQTGSVDAALAGITITAEREKVVDFSHPYYDSGLSIMVMKDNDEIQGPEDIEGRTIAVRTGTTSADHAPRLNPADIVQFPNIEAAYMEVRAGRVDAAMHDTPNVLYYIQTAGDDQVKAVGPRMQSQSYGIGFPLGSELRNDVNVAFLELVDSGEYAEIYKKWFGEAPNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUD3</accession>
    <name>D6SUD3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871606.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0227"/>
    <dbReference type="EnsemblBacteria" id="EFI32913">
        <property type="protein sequence ID" value="EFI32913"/>
        <property type="gene ID" value="Dthio_PD0227"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YVY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2022157at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="11029" checksum="3D92E2F895732945" modified="2010-08-10" version="1">MSEQRDAFVQKLKAKIDEWNAEIDRLNAKAEQVGAEAKMEYLQQVEEIKKHRDDALQKMEQLQEAGEGAWEDMKSGVEMAVDSMVQAAKSARERFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUE1</accession>
    <name>D6SUE1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871614.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0235"/>
    <dbReference type="EnsemblBacteria" id="EFI32921">
        <property type="protein sequence ID" value="EFI32921"/>
        <property type="gene ID" value="Dthio_PD0235"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="410"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="577"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="682" mass="74330" checksum="1510875F8A9A4077" modified="2010-08-10" version="1">MKNIKLSVKLIGGFLIVALITLVVGLIGWRGATNLGGHIEEVGEVRLPSVQSLLQAESALKDLVVAQRTLMSPDLDMNERQDRMNNFDRARENFYERWEFFLTLPATAEEERLSDEFEQEVADWAELNDEWLDMTQEFESIEILNPTQLVSDFRLFRGDHYNAMVDVNNYIAAGETFEGRDDPEACNFGQWLQDMDYDNPELLEMLRAMTNPHNEFHATVISIQDALEQGDTDEAERLYQEEMQYYAEQVFGHFDDILEFAADADQLREDMNDLVLGPIDVESQEALDVLEELVEMNVGLSDAAVQDADADVGQAQWLIILGMGLGTIIAVGLGLFLTISITRPIFKGVEFAKSMAQGDLSQTLDINQKDEVGILAKALNDMAESLRKMFGDISSGVETLASSSTELNSISDDMAKRSETTASKASGVATAAEEMSSNMSSVAAAMEQAATNVNTVATSSEEMSATISEIAQNTEKAKEITGNAVDKSKTSSQRVDELGSAAQEISKVTETIMAISSQTNLLALNATIEAARAGEAGKGFAVVANEIKELAQQTAKATDEIKEKIDGIQNATGLTVSEIQEISRIIDDIDSIIGTIAASVEEQNAATRDIAENVGQASQGIQEVNENVAQTSTVAGDVAKDITEVNTDAGEMSNSSAQVRQSSDELSQLAEKLKELVSRFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUF7</accession>
    <name>D6SUF7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871630.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0251"/>
    <dbReference type="EnsemblBacteria" id="EFI32937">
        <property type="protein sequence ID" value="EFI32937"/>
        <property type="gene ID" value="Dthio_PD0251"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="459" mass="52028" checksum="85635C5922EFC4A3" modified="2010-08-10" version="1">MARVLGVEENHAYHNILSRALGAEHLLTLCSSMSSLGQKTGKTAYDVAVLSLDVNGNGAEDLEPIQKIQEQLGQAPVIVTSEKDDSDWIVRVIRAGAHDFIAKPYSGEKIRLAVDSALEKRSMKNEIDYLRRQQDVIYDLDRIVASTPAMQDILSWTRKYAQTESNLLLTGETGTGKSFLAGAVHFNSPRKKRPFIKINCANLPENLLESELFGHEKGAFTDATQTRVGRLEQAAGGTVFLDEIGEMTPALQAKFLQVVEEKNFQRLGGNRTIYSDIRIIVATNRNLEQMMEASDFRSDLYYRLNILKLHLPPLRERKQCIEPLTRMLLERICRQLRKKMMDISPEALEILGAYHWPGNIRELSNVLERAILLEHSDVITAESIHLNSGLHLQENSYQNSPSASRLENTEYRSIIQALEDNLWVQKHAAAQLGISPRSLNYKIKKLGITHWRWPRHKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUH5</accession>
    <name>D6SUH5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871648.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0269"/>
    <dbReference type="EnsemblBacteria" id="EFI32955">
        <property type="protein sequence ID" value="EFI32955"/>
        <property type="gene ID" value="Dthio_PD0269"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="589"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="652" mass="72066" checksum="168A7A47631CE8CD" modified="2010-08-10" version="1">MTRQPPRKKTKEYSRIKIGLVLAFCFIFWGALWARALQVQVLQGEELAEQAQRQYFSQEKIMGKRGEIFDRQGRVLAQSVRSKSVYANPFLMDDIHAQAAELGRILDVDPDSIRVRLGRKSSFVWLDRKVSDRVAHEVVSADLPGVFIVDEHSRVYPQKHMLGQVLGFVGIDNTGLEGLERSLDKRLSGAEMVLVRQRDASGQRFSLMPRQPDQQVDGEDVHLTIDSRMQFHVEQALADAVEENNGQSGVAMVVHVPTGDILSWANYPFFNPNNYRASSPDIWRNRGATDLIEPGSTLKPFLVAAALEENVARGDSLYYCEQGQWRLGNNQIKDVREYGWLTVNRILRYSSNIGAAKVGMDLGAGTLHSYLTRLGLDQATGAQVPGQSRGLLRPPNTWSNMDLATISFGQGMATSFLQLARAYATLGNHGVYTDLNILQEQSSPVSSQQRVFSRGVSRDVLAMMRDSVERDGTGTRARISGIEVGGKTGTAQKASPQGGYSDEYVASFVGFLPAMDPEYMIMVLVDEPESPYYGGLVAAPAFQRIGGRLLSSQKGLGLRSLALDESSADRESFDRENDRFSVAPRQTRKVDTSSVPDLRGTPLRLAVESLIQAGIEPRLKGTGVKVREQNPSPGSSWDSEEKHITLKLCPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUK2</accession>
    <name>D6SUK2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysulphide reductase NrfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871675.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0296"/>
    <dbReference type="EnsemblBacteria" id="EFI32982">
        <property type="protein sequence ID" value="EFI32982"/>
        <property type="gene ID" value="Dthio_PD0296"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="392" mass="44410" checksum="61A21BEC64FA5848" modified="2010-08-10" version="1">MSTQHHPDTGQSSWFTPFNVIAGLIVLVGIYLTYLRFTGGLAAVTNLDDYYPWGIWISFDLLCGVALAAGGYTTAAACYIFGIKKYHAAVRPAVLTAFLGYALVVFALHYDVGQPWRLAYPIFVQQGTTSVLFEVGLCVFLYLTVLFLEWLPAPLEWLRLKRVRNIVIKLTLVLTIFGVILSTMHQSSLGALYLILPSKMHPLWYSSHLPIYFFVSSMFAGLSMVIFESTLSHRYYHNKMDKEHLEGTPHVTFGFAKAAAWIMAGYFFIKLFGVVLNDNWSYLPTFYGFMFSLEMLGFVALPAFLYAKGVRDKNVRLIKWTAVVAVFGIIFNRFNVSLVAYNYHLPSELKYFPALAEIGVTIFVVTVGLILFKFISTRMPIFYEHPEFKGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUP2</accession>
    <name>D6SUP2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplJ</name>
        <name evidence="7" type="ORF">Dthio_PD0336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0336"/>
    <dbReference type="EnsemblBacteria" id="EFI33022">
        <property type="protein sequence ID" value="EFI33022"/>
        <property type="gene ID" value="Dthio_PD0336"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="174" mass="19902" checksum="B92F5F1E837176D6" modified="2010-08-10" version="1">MLHRDDKGKIIQDLHQQANKAVIAVVTDFQGMKVEEMTQLRRTLRDKNIEFRVVKNTLARIAFEETPHADVKDRFKDCCAIAFGYDDPVTAAKVLVDFEKKSKKFKTRFASLEGRYLEADSMKELSELPSREELLGKMLGTMNAVPTNFVSLFANLIRNMMNALEAIKEQKETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUS0</accession>
    <name>D6SUS0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871743.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0364"/>
    <dbReference type="EnsemblBacteria" id="EFI33050">
        <property type="protein sequence ID" value="EFI33050"/>
        <property type="gene ID" value="Dthio_PD0364"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088207" evidence="2">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="212" mass="25209" checksum="CBCFC91BFE1304EB" modified="2010-08-10" version="1">MKIFILFIFSAAVFFFAGSVQAEDSPGDFLMQQERVSPEFKDEIEDWQARLELARLLSYVQRYDEAIDQYHRVLDEKPDLVQARLELARVYYWTDEIDKAREMFASVPEDKITGEARLELGEIYAMLEQYDRAADIYRDYLQDNPGQDEARFKLARVLSWKGDYEASIQEYERVLESRPGDNQVRRHYAQVLMWAERYDEAIEQMEKTLESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUT0</accession>
    <name>D6SUT0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871753.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0374"/>
    <dbReference type="EnsemblBacteria" id="EFI33060">
        <property type="protein sequence ID" value="EFI33060"/>
        <property type="gene ID" value="Dthio_PD0374"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="415" mass="45272" checksum="F9BB0A3B1B38F304" modified="2010-08-10" version="1">MIRAEILSTGDEIMSGSLVDTNAAWITRQLLQSGLEVGRISCAGDDLRELQSLIQEIAQRADIAVITGGLGPTPDDITAEAAARACGVELEQNRQALQSIEDYFARLQRPMPESNLKQALIPAGSVCLPNPAGTAPGFRLNIHNCCLFALPGVPSEMKQMFDLSVTPWIKKHLAQQLQPMSIRVISCFGISESKTAQALQGFSSSFPDIHLGFRFKFPAIQARLYCRQPAGRTYGQHMEDAVNWVKHRLGDRVFSSRDSTLQEETMQLLADQNKTLAILEGCSGGMLAHLATGTEAGSKALLLARVVHEDFQGFSRTHVDPLHSARELASEIMTDAESDFGLVNFAAKEADQTRVFMGLAGRHRTLAREFTRGYPDRQASITALSWACLNLLRLELLEVIPGNHSSNSASGEPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUU4</accession>
    <name>D6SUU4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33074">
        <property type="protein sequence ID" value="EFI33074"/>
        <property type="gene ID" value="Dthio_PD0388"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937982at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088208" evidence="1">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="107" mass="11730" checksum="DDFC7A611B35F4FC" modified="2010-08-10" version="1">MPKVILSMITLFFVFMLAGCSSGPSDSEVKSLLEEKYEEYNQQASMMPDAQIEVDSIEVHECSQSENQTGYICTVTVEGSTGVTGTGSETSDVRFIESDSGDWRIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUV4</accession>
    <name>D6SUV4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871777.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33084">
        <property type="protein sequence ID" value="EFI33084"/>
        <property type="gene ID" value="Dthio_PD0399"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7VX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="158080at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1070" mass="120478" checksum="8732D26A7F82DE62" modified="2010-08-10" version="1">MDNFTKTGASVSIRKKNPSIDLVSVIDYLSKVLDYFGNLTSDSKAENFFSCKTRKNNSGKQQPSSLIMNTVNILSGIDKGKNFAQEFTPSENSGLIRDVDLSLKSIDTIVGGEIYSDKAQDLTKSVLGLKGKIEKLIESCLKDNNLNVQDLYFKNAQDYVAQINSSLKSHKLDAEKMNMIFNKLSFADPVKHKQSGHAKKVARVITGIEEKQASGWLDDFKTAARRKLEIMETEEDEIEDIINNIDQEAARSGSQTEKFYNFLEDEVLARVRLEVSFAIMKEIRDHAKGNKDRDSALLVRYIDNALELKNKYLNTEDTLLFELGNSVRINLFDRTVNLSDKLRNALFYKCLPIWPHPSSHFFESRSSDGNHLLREVGYRFRVNGINPEAGKKAILARIDSIKDELYFSKNTYNANHKHNIMELLYLSLVFPSPQNFLKIDDVILKCKSFLNQSDVKIDPVERLIKRLNDLEEEGTYSSITNALIKILQQKSGQVLKSAERQIEDLYICVQEDVVDWERLATSEGEATDFFVKPADYNENEKITWLKNIEITTKPSTVAGLLFSIKIKTRLNELLLVQDDPKTYSISAQRKPEGPILPVSIIPHTPTDGGLSGTPVMDAGVPKWCDTGGIIIQVDDEVFSLKSENPSEAQMQLRSALVTLFAVLMQITLWVVREKLAINSAGQHKEMPKIFMLRLQKEGKGGTDKPPSGSEAIYAVFKALELTLGHESSVFMQGLVLDKISKYSNTGASSAILSGFPLVMKTDAGNAQVSNFEPIGILNYATRPCNQFGDTSNSLFLMSSKSYTAFLQTDPFQAMILEEGPSRLNILGESEFDNPKYVFEEISRLERVGCKNIILLWHHHGTWRIGRTAERHAPHSKPDFIERAAQRFPELTLYLFRRDFFPAIRISGQSKHPEAFEVQRASDHSSFQARNKISSGREIIPFYTFATLFVVATEQERPQSGFCTYYLEFDSRVSSVEWAEKARATIIDSDRSSIMRPAIITALRGLHYLHAEKPVSNKSIQPKLYPYDWINPQSIGGLGEMHAIKGPGKPNVIISFPAVLSRVTSVLRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUZ1</accession>
    <name>D6SUZ1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871841.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32747">
        <property type="protein sequence ID" value="EFI32747"/>
        <property type="gene ID" value="Dthio_PD0035"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891199at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="214" mass="24542" checksum="ABEB82C4CDB329FD" modified="2010-08-10" version="1">MPTKKITYLVDGFNLYHSVRKAGKQLKASTKWLDLKSLCISMIHNFKPKADKLELENIYYFSAYAYHLNDPDMVQRHKSLVACLEDTGVKVEINRFKYKAIDCPFCNKTIPKYEEKETDVSIALKLQEIFIKDECDVAILVSGDTDLAPAVRLAIKLFPAKHTFFAFPAFRKNNELAKLCSGSITIKPKQYSKHQLPNPYILQNSSKIFKPASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV19</accession>
    <name>D6SV19_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871865.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0068"/>
    <dbReference type="EnsemblBacteria" id="EFI32775">
        <property type="protein sequence ID" value="EFI32775"/>
        <property type="gene ID" value="Dthio_PD0068"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031KAE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2008719at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="67" mass="7902" checksum="9C0E2029DF6E8581" modified="2010-08-10" version="1">MSKILRTEDIAEMLRTTTAAVRCHISRQKWDVVPKPFKLGRKWAWLSEDVNNWLNDQKNQGGKNYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJT9</accession>
    <name>D6SJT9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="10">R protein</shortName>
            <ecNumber evidence="10">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HsdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869267.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3596"/>
    <dbReference type="EnsemblBacteria" id="EFI36142">
        <property type="protein sequence ID" value="EFI36142"/>
        <property type="gene ID" value="Dthio_PD3596"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25184at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021810">
        <property type="entry name" value="T1RH-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11867">
        <property type="entry name" value="DUF3387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="286"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI36142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1078" mass="123978" checksum="42A1ADE7CED56040" modified="2010-08-10" version="1">MTPSDYSENTLVEQPAISMLDELGWKTFDAYSEFDHGSSSLGRENKGEAILKTRLLQALQQLNPDIPVEALQEVITELSKDRSRMSLAAANKEIYELIKHGMRVSVPNTEDEEERIEWVRIIDWENPLKNDFLLCSQFWVTGEMHTRRADLVGFVNGLPLVLMELKAIHRRLETAFTCNLSDYKDTIPHLFWTNALIILSNGSQSRVGSVTAGWEYFSEWKKIDDEEEPGRVSLETMLKGVCEPSRLLELVENFTIFQEVPGGLIKLIAKNHQYLGVKNAIKALENIQEHKGKLGVFWHTQGSGKSISMIFFAQKVMRKRPGNWTFVIVTDRHELDIQIYKNFVSAGVVTEGRAQAESSQHLRQLLTEDHRYVFTLIHKFRTEKGEIHPVLSEREDIIVITDEAHRSQYDTLAMNMRTALPRASFLAFTGTPLIVGEEKTREVFGEYVSIYDFKQSVDDGATVPLYYENRIPELQLKNEDLDKEMERILEEAELDEEQEKKLEREFAREYHLITREDRLEAISKDLVSHFITRGFRGKGMMICIDKATAIRMFNKVQKYWQEKINSLEKELVRADSQSKDVLSERLKWMKETDMAVVVSQGQNEIGDMEKKGLDIRPHRKRILEEDLENRFKDPEDPFRLVFVCAMWMTGFDVPSCSTLYLDKPMRNHTLMQTIARANRVYPGKVSGLIVDYAGVFRDLEKALAIYGARGGKDDGNRPVEDKAALLEALKQSLRETEEFCKRHGVDLERIEQAEGFGRIGLLDDALKALVPPEQLEKAGIINRQEDMDDAVESLVGSEEAKRKYLDLAKTVDRLYKAVLPDQEAKAFSVKVAPIQIIAQKIRNLTPPADISLVMGQVEELLDRSIKPEGYVMPESTPDNPENLIDLSGIDFEKLAEQFKKGRKKTINEKLKGMVARKLMMMVRLNRTRINYMEKFQKLIEKYNEGSMNAEEFFRQLKEIVRSLDLEEQRAVSENLSEEELALFDLLTKPDLELSDSDRKKVKATAKELLTKLKTEKLVLDWRKRQQTRAEVRITIEKILDEGLPRAFTPELFEQKTTAVYQHVYESYYGVGQSVYAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJU3</accession>
    <name>D6SJU3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869271.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3600"/>
    <dbReference type="EnsemblBacteria" id="EFI36146">
        <property type="protein sequence ID" value="EFI36146"/>
        <property type="gene ID" value="Dthio_PD3600"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2231478at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087853" evidence="1">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="11849" checksum="1273B76F1CDF167E" modified="2010-08-10" version="1">MKTFSLFVLPFLSIFLFATPAGSEEPENFCHEPEALAEWEAMNQKYPRDLNVQTLHALRIGLCEKIDRGDIGVADGIAIFESMRQAVLSRVFERQMREQGEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJV5</accession>
    <name>D6SJV5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3614"/>
    <dbReference type="EnsemblBacteria" id="EFI36158">
        <property type="protein sequence ID" value="EFI36158"/>
        <property type="gene ID" value="Dthio_PD3614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088206" evidence="1">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="12178" checksum="EB70783E4A0B33EE" modified="2010-08-10" version="1">MKVLSFLLISLLVFTVPSTTNAFFGSKTHDECILDRMPGVQNNRAASEIRRACHNKYPKAAEPKRRLGIFGPKNYEECMLEHLTGDESDWAVNYIRSSCRRIFPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJW0</accession>
    <name>D6SJW0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869285.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3619"/>
    <dbReference type="EnsemblBacteria" id="EFI36163">
        <property type="protein sequence ID" value="EFI36163"/>
        <property type="gene ID" value="Dthio_PD3619"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2022621at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="179" mass="20025" checksum="AB99BAD2EBEA38C4" modified="2010-08-10" version="1">MKSEKNSPPVPPQHQGRISNVDGLLRAIEAYFDSCDDQGMSYTLAGLQYYLGVIDKQLLWGEQVSKSSEPQKTVKLYNSPDVRRALQVARLRIQAQRATQLLDDEKNTQAQIFDLKANFAWVDKQGLEVTSPDNSVGSKVAVVLPAAPGSVSMDEWQKMYQEVMSRRKSVHELKVGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKC3</accession>
    <name>D6SKC3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3792"/>
    <dbReference type="EnsemblBacteria" id="EFI36326">
        <property type="protein sequence ID" value="EFI36326"/>
        <property type="gene ID" value="Dthio_PD3792"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZB6Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021679">
        <property type="entry name" value="Toxin_endonuclease_YhaV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11663">
        <property type="entry name" value="Toxin_YhaV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="13514" checksum="2BBE0F9588D7C0CA" modified="2010-08-10" version="1">MQSHGWTLLFHDCLIQQLKRLSAACQRARSSDPEGWLANANVKLYHALSRLMLRTIPADPGHPVYRQGNTLGEDHRHWCRARIGRRFRLFFRYDSASKIIIYAWVNDQQTEVVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKK7</accession>
    <name>D6SKK7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868352.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35218">
        <property type="protein sequence ID" value="EFI35218"/>
        <property type="gene ID" value="Dthio_PD2627"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032FHC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2179621at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="81" mass="9592" checksum="772032B0F03BD3DD" modified="2010-08-10" version="1">MQQITIRGIDPEVEQEIRRRADQNQKSINQTIKEIIYEQIRPVKPPTSSLKQLSGRWTQEDAAEFESAVKFCEQIDEEMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKQ7</accession>
    <name>D6SKQ7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868401.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2679"/>
    <dbReference type="EnsemblBacteria" id="EFI35268">
        <property type="protein sequence ID" value="EFI35268"/>
        <property type="gene ID" value="Dthio_PD2679"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="78" mass="9150" checksum="3C12CFE7FF0FDF00" modified="2010-08-10" version="1">MKTTAKDLRFFSREILDTVSRGEEVIITYRGKPCARLVPYQAAKDDEYKEKLFGMWQDNESVADVDGYIRRLRQGRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKW3</accession>
    <name>D6SKW3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868456.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2739"/>
    <dbReference type="EnsemblBacteria" id="EFI35324">
        <property type="protein sequence ID" value="EFI35324"/>
        <property type="gene ID" value="Dthio_PD2739"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="7">
        <location>
            <begin position="126"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="293" mass="32982" checksum="3BC6D72668418194" modified="2010-08-10" version="1">MSKLDKALNKARHDRESISSSFVLESEKPVQNKLARAYEKASSQQEKRDLLSALRPVAEHTDKDIKFKYHKTRVLPPVEKILEKQRILTHLRKPGFRDSYDYFCTQVLQRTREKGWNSLMVSSAYTGEGKTTTAINLALSIAREMQQTALLVGANFRNPKVCTYFGLDEDRPGLSDYLVNGSSISDLLFSPGMEKVVVLPSGKRTSNEKNFLSSPKMKSLVEELKARYPDRYVIYDCPHVLDMPDTLVFTSYVDAVLLVVEAGRTPGHDVERAVQTLTDRGVNIVGVLLNKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKZ9</accession>
    <name>D6SKZ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868492.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2775"/>
    <dbReference type="EnsemblBacteria" id="EFI35360">
        <property type="protein sequence ID" value="EFI35360"/>
        <property type="gene ID" value="Dthio_PD2775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="110"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="434" mass="49877" checksum="ACC1E7C22B4C17A6" modified="2010-08-10" version="1">MPKKNIFIVGLDEFNKKLLQQLPQAAECEFHAALDISDIRNVQSYDMQHLIDKAVGRMESFKGSIDGVATYYDFPGTVLVPILARRFGLPGPDLESVLRCEHKYWSRVEQKEVIPEHIPMFQPFDPFDAQGFEKLRLLPPFWIKPIKSFKSFLSFRINDELEYWEATNKIRKSIALIDEPFRYLLQNYAQVPYEIAHMHESCLAESPIGGLQCTLEGYSFKGEIVGYGIVDSVQEKISSSFARYQYPSILPLEIQHRIMDTARKAIARIGMDNSAFNIEFFYDQTAQQVYLLEINPRISQAHTDLFAKVHGHSHLSVMVDLCLGRKPRILERNGPFSVAGHFMLRTFEDGRVVQVPAQEQLEKVREKFPGTQMKILVRQGDRLSELLALQDSYSYELANIIIGGMDGSNLLEKYNHVLDLLSFKIDKEEYIAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL45</accession>
    <name>D6SL45_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868538.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2822"/>
    <dbReference type="EnsemblBacteria" id="EFI35406">
        <property type="protein sequence ID" value="EFI35406"/>
        <property type="gene ID" value="Dthio_PD2822"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="297" mass="32544" checksum="606C525E6B72E8C0" modified="2010-08-10" version="1">MQEIVVISGKGGTGKTSLVSGLAATGTRQVLGDCDVDASDLHLIMAPEILEAHEFINGQQAQIVPDLCTGCGLCRAYCRFQAISEDYRVMQEHCEGCALCLHVCPESAVSMHDRHCGQWFSSSTRFGPMIHASLGIGQENSGKLVSIVRKKSHQTAQEEAAENVLGDGAPGVGCPVIASLTNADMALLVTEPTRSAFADLRRVFDLTRHFKIPCLAVINKADLNPDITVEIERFCLEYGLGVPVKLPYDQDFTRAQIQGQSIVEYHPEKWTRPMQDIWKSAAKILKHKNNPGRNKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLG9</accession>
    <name>D6SLG9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868662.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2954"/>
    <dbReference type="EnsemblBacteria" id="EFI35530">
        <property type="protein sequence ID" value="EFI35530"/>
        <property type="gene ID" value="Dthio_PD2954"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZSNU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="278" mass="30586" checksum="16B4F7D642A2F2F4" modified="2010-08-10" version="1">MSSISKRYFPGHGRGFWISYSGVLMCALLLLLTLYIPLHSKAVLASEPVDTTLVGCVVERSFYSLGHPLFEHDLNRAEEIYKGLVSDTPGLGDVYQIYPHIDKSPYELLDLSDYEGKSLGIKGSLLPGDTFFVSGADSVTVLQDACHENLLDVITQKMELVSSALSTDAGADEPTDISHSGQGRAAPSFETDLPPELLPLAEQDALTVRALRGWGMLPEKFDSLILAFQHLDSDLLGADHRQIRVLSQEARQDSQLEQWADPLEQLAESMALITREVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLI0</accession>
    <name>D6SLI0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2965"/>
    <dbReference type="EnsemblBacteria" id="EFI35541">
        <property type="protein sequence ID" value="EFI35541"/>
        <property type="gene ID" value="Dthio_PD2965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="34" mass="3832" checksum="2A4F903736C082CF" modified="2010-08-10" version="1">MIRDVCVYVSVGVWKCKKEEEDGRHGAKRMGHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLL4</accession>
    <name>D6SLL4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868704.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3001"/>
    <dbReference type="EnsemblBacteria" id="EFI35575">
        <property type="protein sequence ID" value="EFI35575"/>
        <property type="gene ID" value="Dthio_PD3001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14701at1224"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="269" mass="30043" checksum="1856A6C89A8FAB97" modified="2010-08-10" version="1">MSIQFNQDLEITLGTPFTDLFANTDEEQTSWYRLWTGKLDNEGEVVRGAMVGDGWVSKDGLDDLTVGVDQAGHNTLYVQTYTDELNSWEHSTEMSFPEEITFELAIEKDVVSEDTLLSDMFSFDTPVSSSEVWFQVKVEGEPIDTTVGNGWVRGDRLGGEYFPAKHAGKELEVTPFYAGELHTDKAQTQMVDRAEHYELSIDKAYVEEDTPLSEMFSYNVSVQTGTPIHGRVSLVVFPGPLDMQQARGMMVGISRQWGKAGLPDLCTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLV4</accession>
    <name>D6SLV4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868794.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3094"/>
    <dbReference type="EnsemblBacteria" id="EFI35665">
        <property type="protein sequence ID" value="EFI35665"/>
        <property type="gene ID" value="Dthio_PD3094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1015470at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="456"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="550" mass="62713" checksum="A6A87F9DAD7B4D7D" modified="2010-08-10" version="1">MWDQSLREITLGTLLDEAVENYPDNDAVVYVDRDFRLTYREFSHVVDQMARGLMTLGVKKGEKVAIWASNVPHWVALQFATAKIGAVLLTINTYYKEHELSYVLKQSEAENIFIIDGFRDTDYVRTLYDLVPELRTQARGYLNNKDFPHLKRVFFLGQEKHRGMYSLPELLALGGMTSDRDYQARRRELDPHDVVNMQYTSGTTGFPKGVMLTHYNIANNGYWIGEHQKLTHRDRICLPVPLFHCFGCVLGVLAAVSHASTMVILEGFNPLMVMTSVEAEKCTALYGVPTMFIAVLDHRMFSKFDYSSLRTGIMAGSPCPVKVMRQVMDKMNMSEVTICYGLTETSPVMTQTRTDDDIRRKTETVGRPMPEIEVQVVDPETNRTLGPGEQGEVCCRGYNVMRGYYNMPEETSRTIDADGWLHSGDLGVMDEDGYLSITGRLKDMIIRGGENVYPREIEEFLYTMEGVRDVQVVGVPSNRYGEEVGAFIILKEGYDYAPEDIRDFCRGRIARYKTPKYVAFVDEYPMTASGKVQKYKLREMAAELFPQAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLW2</accession>
    <name>D6SLW2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="9">KARI</shortName>
            <ecNumber evidence="9">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="9">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ilvC</name>
        <name evidence="13" type="ORF">Dthio_PD3102</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9 10">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868802.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3102"/>
    <dbReference type="EnsemblBacteria" id="EFI35673">
        <property type="protein sequence ID" value="EFI35673"/>
        <property type="gene ID" value="Dthio_PD3102"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="188901at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="9 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="11">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="12">
        <location>
            <begin position="182"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="329" mass="36626" checksum="137651B3AB18B612" modified="2010-08-10" version="1">MKVYYENDADLSLLKDKTIAVIGYGSQGHAHAQNLRDSGLNVVIGQRPGGANYNLAREHGFEPVAAAEAARQADLIQILVQDQYQPGVFYNEVLPHLDSGKTMVFSHGFNVHYNQIVPPKDVDVVMIAPKGPGHLVRREYARGGSVPALAAVYQDHTGQAWDKALAYAKGIGATRSGVIQTTFAEETETDLFGEQAVLCGGVSALIRAGYETLVEAGYQPEVAYFECMHELKLIVDLLYEGGFTRMHYSISDTAEYGDYSRGERIVGDQAKQEMRKVLGEIQDGRFAREWILENKAGLPAFYAQRRKYHSHQIEEVGERLRKMMAWLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM14</accession>
    <name>D6SM14_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsT</name>
        <name evidence="10" type="ORF">Dthio_PD3154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868854.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3154"/>
    <dbReference type="EnsemblBacteria" id="EFI35725">
        <property type="protein sequence ID" value="EFI35725"/>
        <property type="gene ID" value="Dthio_PD3154"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="10287" checksum="C1853B4373E42C25" modified="2010-08-10" version="1">MPNIRSAAKRHRQNLKARERNKAVKTRIKNVTKAVHQAVNQQDADQASRAIQKAASTLDKAAQKRVIHWKKAARKISRLNRMVNTLQSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM68</accession>
    <name>D6SM68_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868908.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3214"/>
    <dbReference type="EnsemblBacteria" id="EFI35779">
        <property type="protein sequence ID" value="EFI35779"/>
        <property type="gene ID" value="Dthio_PD3214"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9593" checksum="522C766A50FFCAB7" modified="2010-08-10" version="1">MSKKVYVYALSTCVHCKNTKKFLEEEGIEYDHVDVDQLTGDEREKVVNEIKEYNPKLSFPTLVVDGEKVIVGLQKDEIKEACGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM70</accession>
    <name>D6SM70_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen-fixing NifU domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868910.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3216"/>
    <dbReference type="EnsemblBacteria" id="EFI35781">
        <property type="protein sequence ID" value="EFI35781"/>
        <property type="gene ID" value="Dthio_PD3216"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2010888at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="73" mass="8096" checksum="DB182F23AFF85C6D" modified="2010-08-10" version="1">MKEQVQEVLEKIRPSLQADGGDVELVEVTEDNVVKVQLQGACKGCPMSQMTLKNGIERLIMQELPQIKSVESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMC5</accession>
    <name>D6SMC5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868965.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3272"/>
    <dbReference type="EnsemblBacteria" id="EFI35836">
        <property type="protein sequence ID" value="EFI35836"/>
        <property type="gene ID" value="Dthio_PD3272"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="109" mass="12313" checksum="FAEED37EB42F46B7" modified="2010-08-10" version="1">MKVRTYSRYTLRAISLLATLIKTGRLEKRIKTQELAERAGISRDLLYRIEKGDPRVELGVALEVAAIVGVPLFSADVSEIEERSKQASEKLALLPRAVRNRQMKANDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SME2</accession>
    <name>D6SME2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868982.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3292"/>
    <dbReference type="EnsemblBacteria" id="EFI35853">
        <property type="protein sequence ID" value="EFI35853"/>
        <property type="gene ID" value="Dthio_PD3292"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="232" mass="27053" checksum="B9E8D84486957529" modified="2010-08-10" version="1">MKKSKILVIEDEEDIQNLLHINLEAAGYRVFLTDNGYDGLKIAREEQPELIILDLMLPHMDGLEVCRRLKKDDKLKDIIVIMVTAKSEEMDRVVGFELGADDYVVKPFSIRELLLRIKAVLRREYRSDSGVERIWKHKGLEFDFEAMEFKVDGINVSLTATEMKLLQEMVQNEGRVLTRERLLNNVWGYEFEGYARTVDTHVRRLRAKLEPYSDLIQTARGLGYKFSTEKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMJ3</accession>
    <name>D6SMJ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869032.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3343"/>
    <dbReference type="EnsemblBacteria" id="EFI35904">
        <property type="protein sequence ID" value="EFI35904"/>
        <property type="gene ID" value="Dthio_PD3343"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="130" mass="14831" checksum="7937896B46CC6D78" modified="2010-08-10" version="1">MPDKYQFKQIIEHVRQDERILALYLMGSAATGKMRPDSDVDLALLVKDPKLFSDMDRLHLAGDLAFMTGLMLDIGEISSRNLVYAKEALLTGQRIFVRDKSEADLKACTLLGMYIVFNEERQEVLRAYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMK2</accession>
    <name>D6SMK2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869041.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3353"/>
    <dbReference type="EnsemblBacteria" id="EFI35913">
        <property type="protein sequence ID" value="EFI35913"/>
        <property type="gene ID" value="Dthio_PD3353"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZB6Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1586867at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021679">
        <property type="entry name" value="Toxin_endonuclease_YhaV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11663">
        <property type="entry name" value="Toxin_YhaV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="153" mass="17993" checksum="A7348234B441F5AB" modified="2010-08-10" version="1">MQSHGWTLLFHDCLVQQLKRLFAACQRARSSDPEGWLANANVKLFHALSRLMLRTIPADPGHPVYRQGNTLGEDHRHWCRARVGRRFRLFFRYDSASKIIIYAWVNDQQTLRQAKGKKDPYTVFKKMLHQGNPPDDWDQLLNEASSEYKIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SML1</accession>
    <name>D6SML1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869050.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3363"/>
    <dbReference type="EnsemblBacteria" id="EFI35922">
        <property type="protein sequence ID" value="EFI35922"/>
        <property type="gene ID" value="Dthio_PD3363"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2907">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="428" mass="47904" checksum="10061C5B7CD6CD88" modified="2010-08-10" version="1">MNSHNQLSGAGSLKIAVIGGGAAGMAASYYLGRRHRVDLFEAEQILGGHVQTVMAPDGDEQKIPVDMGFIVFNDTNYPRFIRFLQDLQVQSAPTDMSFSYSESHTGFAYSGSTLSGLFARRANIIDPRFWRMLFAIRSFCRNVTRDLQEGKLTGGTLGGYVRDNRYPEILMSRYLAPMVRAIWSAESSGPEEFPLERFAQFFFNHGLLSFSGGPVWRYIPGGSHTYVQAFEKSFTGSIYTSSPVQAVFRESTGPVLQVQGQKMEYDALVLACHADTALQLLQDPDPGETACLSPWRYAANDVFMHTDDSFLPHNTRAWACWNVISHSGDTQERVNVHYWMNRLQRFQAQKNHVVTLNPRRPVPAEKTSRHLKMMHPQFTRDALDAQARFGQLQGVRGTYFCGSYHGNGFHEDAAASGMRVAELLGAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SML4</accession>
    <name>D6SML4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3367"/>
    <dbReference type="EnsemblBacteria" id="EFI35925">
        <property type="protein sequence ID" value="EFI35925"/>
        <property type="gene ID" value="Dthio_PD3367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="48" mass="5341" checksum="36F13019BCF62BF1" modified="2010-08-10" version="1">MDKEKNYFVLAGSQAKRLSLQHSLFSGSHESQKKVSAGWLMQSEASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMS2</accession>
    <name>D6SMS2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869111.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3425"/>
    <dbReference type="EnsemblBacteria" id="EFI35983">
        <property type="protein sequence ID" value="EFI35983"/>
        <property type="gene ID" value="Dthio_PD3425"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZA7Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1897347at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="170" mass="19593" checksum="38BDC5B18A7E5EC1" modified="2010-08-10" version="1">MPEKDLDIMDREELRKLAGSLLWQLRLADAFWFINIEKRMGLEGAEEVNALVWEQVGRLAARDIIGRFAIKEKGLQGLLQALKYFSWGLMLDYDVQSGDKEMILSVPVCPAQEGRKKHGLGEYSCKEMHLREFTAFAGEIDPRIRVHCIFAPPDDHPPELYCRWRFDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMS5</accession>
    <name>D6SMS5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3428"/>
    <dbReference type="EnsemblBacteria" id="EFI35986">
        <property type="protein sequence ID" value="EFI35986"/>
        <property type="gene ID" value="Dthio_PD3428"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032T1H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="285" mass="32736" checksum="AAA683967EBDF7C5" modified="2010-08-10" version="1">MLINMLNSCQKRLIYNLAYIPEHLPSYLCPFSDSEPCMDGGLLYYQAKEKISLMACPLPLNTKGPELYSHVNSLVRELKPAELGCISPVPLDVHGYKPVRTEYDLYYCLDLNNILSGPKLRNMLKRASSEVHISVGRDFTRDHLELLRKFIEFKGLDQEKALFFHRIPEYLSHSDTALVIEARTIRDNSLVAYDILETGSRLFAFYLFNITGKKSRDIPGVNDLLLQEAINQARKLDKKYINMGLGINPGIVSFKAKWGAYPFLAYYFQQFQPAFSWKRFFGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMV1</accession>
    <name>D6SMV1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="7" type="ORF">Dthio_PD3454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869140.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3454"/>
    <dbReference type="EnsemblBacteria" id="EFI36012">
        <property type="protein sequence ID" value="EFI36012"/>
        <property type="gene ID" value="Dthio_PD3454"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1510750at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="106"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="353" mass="39945" checksum="160F854C65514C8C" modified="2010-08-10" version="1">MTLDQRQADVLFTIVRNYIQSGQPVGSRTVARQSSLNLSPASIRNIMADLAEEKYIEQPHTSAGRIPSTKGIRYYLDSKLDLELLPGGLEETIKSSLSEVGPDLTNTLSQASKVLSSLSNQISLVVTPSQKNIRWKHIDFILLRPGLVMSILVMEGGMMQNKVVNVDSDISADDLVKFSNYLNDHYQGKTLQQVRTSIVSQMEKARRQFDHLYQNALKLARESFDPGNNRQVYVDGTHYLFQDTDFTDLSKMREVFRLLEERSKLLKLLDNTLESDGLSILMGQEQDWEELSDYAVISSPYSLQDDSVGHVSIIGPTRMNYSRIIPTVDLTARILSQIFRELYENNKDSSINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMV5</accession>
    <name>D6SMV5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="2" type="ORF">Dthio_PD3458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869144.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3458"/>
    <dbReference type="EnsemblBacteria" id="EFI36016">
        <property type="protein sequence ID" value="EFI36016"/>
        <property type="gene ID" value="Dthio_PD3458"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1780195at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10749" checksum="D918093849C2BC31" modified="2010-08-10" version="1">MNIDKEYVSRIAALARLETSPEQAEKFAVQFRDIIGYMDSLNQVDTSGVEPFYSPSENISVLREDETRKTCRRSDILASAPHHDGEYFIVPRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMZ3</accession>
    <name>D6SMZ3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869182.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36054">
        <property type="protein sequence ID" value="EFI36054"/>
        <property type="gene ID" value="Dthio_PD3497"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZZMJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1217533at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025639">
        <property type="entry name" value="DUF4338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14236">
        <property type="entry name" value="DUF4338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4338" evidence="1">
        <location>
            <begin position="69"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="299" mass="34004" checksum="4E54F3D4B9592BB4" modified="2010-08-10" version="1">MVQEISQKFCGREFTSEEVRLVQEVVRNCAGLSRTELSHTVSELLEWKRPGGGLKARECMDFLEQLAVHEIIDLPGKKSSGKAKPRKSIAAVQDSRPYSHLCGSVEEFTPLDVELVENREQRLLFQDLLSRYHYLGYAMPYGARLQYLIHTGRPRREVVACVQFSSPAWRIKARDQWIGWDDGTRSKRLQHVVNNSRLLILARIKNLASMALSRALQHLGVDWLERYGVEPLLVETLVDRQRFHGGCYLASNWKLLGDTSGRGRTDRAHKRHGSEVKKVLVLPLVKNAVTRLSGKGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN44</accession>
    <name>D6SN44_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1518"/>
    <dbReference type="EnsemblBacteria" id="EFI34170">
        <property type="protein sequence ID" value="EFI34170"/>
        <property type="gene ID" value="Dthio_PD1518"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="14"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="339" mass="39532" checksum="5F93A0F5B66710A0" modified="2010-08-10" version="1">MLYSSLMSDTSKYHDHTFRAILGREPVARDFVRYHLPEEITRDMNLDTVKVSSRSYVSDNLKESMTDIVITLKLNTGEPAEIYILVEHKSDLDAWTKIQLFKYMNEVWQSFIQKKTGTLPIIVPLVFYHGTARWNYSLEFSDLFNLPSEHYRKYIPKFEHLLHEVPEINKKKAKTSITLEVFHLVLEYIFYPEKRDQIYEALELLFKGLDAKEAHEIFAILIKYLLIATDETPEEAEEKVKHLPKGGETVRTTAEVLEERGYNKAIKEKPIWERQAELKNAKETLIDVAGDCHGPLPNSLQDKIKSIESIDNLRTLTRKVYKTQSLEEFTELVNRAAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN53</accession>
    <name>D6SN53_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869509.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1527"/>
    <dbReference type="EnsemblBacteria" id="EFI34179">
        <property type="protein sequence ID" value="EFI34179"/>
        <property type="gene ID" value="Dthio_PD1527"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891199at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="213" mass="24697" checksum="6B451077D0E40B56" modified="2010-08-10" version="1">MTRKVIIFTDGMFMRRRVLERNHFLYKPREIREYCQKHLRPNDYLVRIYYYDCKPLQARGTSPLNGKEIDFSRLESARLRHQLFEGLRHAPNFCLRLGSMEWNGRDWNVVGSKVSPLLKKEITVDDLSDSDIRPGSETTQISVKMALDMITLAARKAGDMFVLITDRTDLVPAMEMVRQEGVQVCLDNMHAPVSIELSEQADFISTQLNNKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN96</accession>
    <name>D6SN96_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869550.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1573"/>
    <dbReference type="EnsemblBacteria" id="EFI34222">
        <property type="protein sequence ID" value="EFI34222"/>
        <property type="gene ID" value="Dthio_PD1573"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="311" mass="34390" checksum="2AA0F2C5FA3EE1E4" modified="2010-08-10" version="1">MDKVVITGGCGFIGLNTIDYLKKNKSHLKISVLDNESLGRKEYLKEFEGLEFFSGDIRDSDLVDRVLYGADAVVHLAADTRVLDSIADPVKNFQINVLGTFNVLNAVRNHSVPLLVNASTGGAILGEVSPPVHENMIPEPISPYGASKLSIEGYCSAFSGSYGVKASSLRFSNVYGPRSYHKGSVVAAFFKRILADKPIDVYGDGTQIRDYVYVDDICQGIYSSLNIGAEGVYQLGTGIPTSINQLIEIMQDVVGEYRDIKVRYHGFREGEIHTTYCDISKAEKALRYHPKTELTQGLKLTWEWFKNCTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNB6</accession>
    <name>D6SNB6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869570.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1593"/>
    <dbReference type="EnsemblBacteria" id="EFI34242">
        <property type="protein sequence ID" value="EFI34242"/>
        <property type="gene ID" value="Dthio_PD1593"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50315HT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="126" mass="14646" checksum="D6BD20DE5AC8CA3C" modified="2010-08-10" version="1">MGKFAKSFRELEVYQNALDLAGEINTFARTFPIEERFALGGQIRRASMSVCLNTAEAWRKRRYKAAFIAKLSDAETEATEVQACLDLARKFGYLEDERHQDFDERYEYIIAQLITMSNKADNWCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNE6</accession>
    <name>D6SNE6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quinone-interacting membrane-bound oxidoreductase complex subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869600.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1623"/>
    <dbReference type="EnsemblBacteria" id="EFI34272">
        <property type="protein sequence ID" value="EFI34272"/>
        <property type="gene ID" value="Dthio_PD1623"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="895090at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="380" mass="42863" checksum="CC9B68686B13ED42" modified="2010-08-10" version="1">MSTRIDPDVQFIREMQAAGGESLKKCYQCATCSVICPLSPEETPFPRKEMVWAQWGMKDKLVNDIDIWLCHNCGECSDYCPRGAKPGDLLAALRNTAYKSLARPAILGEWMSSAKYLPVLFAIPAILFLIVWAITTGLTIPDGEIVFSKVFPTLQAIDPIFILTVIFVVFTFIYSVGRMLSSFKEAGYVPQEGSPSLLRSLYDVIKEQILTHVKFKDCETNQERYTGHLLVFYGFVGLFLVTAFVATAYWMNIFGIVDFATPMAMWNPVKIFANIAGIALIVGLVYMTRMRLNIDPKKTVNSFYDWYLLGVIWAVVITGFLAQIFRLADAAALAYIVYYLHLVTVFMLFAYLPWSKLAHLVYRTVALAYARQIGRKGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNG8</accession>
    <name>D6SNG8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system F domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869622.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1645"/>
    <dbReference type="EnsemblBacteria" id="EFI34294">
        <property type="protein sequence ID" value="EFI34294"/>
        <property type="gene ID" value="Dthio_PD1645"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="67"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="401" mass="43729" checksum="A5A6395017B5E687" modified="2010-08-10" version="1">MPIFLYKATSKSGKKLKGDLDAPSLDMAKATLKRKGLKDIQVKPKPKDILEGTFLEGRVTSRDMVVFSRQFATLINAGVPILQALQVMCDQTENKILRRKLYEVKNDIEGGSSLYDSLKKHPDVFDDLYTNMVDAGEAGGVLDLVLDRLARYIEKAARLKARVKSALIYPGVIITVAVAVIAIILIFVIPTFEDMFADFGGALPAPTQFVIGLSRFVSQNVLWILGGLIATVLGIRLIYRTERGRTLIDEWILHAPVFGPLLRKVAVARFSRTMSTMISSGVPILSALDIVSRTAGNKSVEHAVQEAKQSITEGQSLAEPLSETGIFPPMVTQMISIGETTGALDGMLEKIADFYDDEVDVAVDTLTSLLEPIMIVFLGVVVGGLVISMYLPIFQIADVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNJ4</accession>
    <name>D6SNJ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Dthio_PD1671</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869648.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1671"/>
    <dbReference type="EnsemblBacteria" id="EFI34320">
        <property type="protein sequence ID" value="EFI34320"/>
        <property type="gene ID" value="Dthio_PD1671"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="140"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI34320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="218" mass="24138" checksum="35810AC6D31383A3" modified="2010-08-10" version="1">MFDISYLVNQVIPMVIPLLLGVTLHEVAHGYTAYRFGDPTARNAGRLSLNPVRHADPFGTVLLPLLLILMKSPFLFGWAKPVPFNPSYFQDARKGIFWVALAGPTANFALAVAFFLLLQGLAIMQPVLDPGNSGYLQPVMMVAYFGIFINIILGIFNLFPIPPLDGSKVLATFLPGRMAGQYMQLEKYGFIIIILLLFLGVFQTVFGHVINFVNSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNM4</accession>
    <name>D6SNM4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module antidote protein, CC2985 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869678.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1701"/>
    <dbReference type="EnsemblBacteria" id="EFI34350">
        <property type="protein sequence ID" value="EFI34350"/>
        <property type="gene ID" value="Dthio_PD1701"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1897062at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038296">
        <property type="entry name" value="ParD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="87" mass="9783" checksum="FDB3F8C6A986EADA" modified="2010-08-10" version="1">MSRATTTMTVRLSGALSEFVTANVGEHGAYENVSEYVRDLIRRDKERKEADTFERLKAELTHAYAAPEASYHPLTAAEVIARNRNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP17</accession>
    <name>D6SP17_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869815.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1852"/>
    <dbReference type="EnsemblBacteria" id="EFI34493">
        <property type="protein sequence ID" value="EFI34493"/>
        <property type="gene ID" value="Dthio_PD1852"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087999" evidence="3">
        <location>
            <begin position="22"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="397" mass="44173" checksum="BAF67CB8CB283BFB" modified="2010-08-10" version="1">MSTRKKIILVLAGLAILGALAAALTPSPVPVSTVQVEKGYFAEYVEDEGYTRLKTTYVMSAPVQGYLHRVDLEPGDGVQAGEVLFSMEALPAPGLDLRAQEQARENLRAARARLESARAEHENARIQMDYAAREVRRHEELFAHNVISASVMDKMHNEQMRATAAKKAARSAMEAALFEKENARAVLDITQGARLGREQGLKIRSPVSGMVLNRMHYQEGTVPAGVEILEIGDLDELEVRVDLLSMDAVRVRPGMRVELERWGGEKPLAGRVRRVEPAGFTKISALGVEEQRVPVLVEITSPRQDWEQLGKEYRVEARFILWEGLEVMSVPSSALFRENGKWQLFVLQEGRAMVRRVETGRRSGLRTQVVQGLEPGEKVITHPGDQVRDGVRVDIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP32</accession>
    <name>D6SP32_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP dicarboxylate transporter, DctP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1867"/>
    <dbReference type="EnsemblBacteria" id="EFI34508">
        <property type="protein sequence ID" value="EFI34508"/>
        <property type="gene ID" value="Dthio_PD1867"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00787">
        <property type="entry name" value="dctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088001" evidence="2">
        <location>
            <begin position="26"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="37461" checksum="CA149F3DBBF4935A" modified="2010-08-10" version="1">MFKRIILMAVCLCVFFGMMASSASAQQVMRLGMGDPIDSDQGAFAQRFKEVVEELSNGEIRVELFPGGVLGQEPEMLQNVRMGQLEVAIVAVGNVAPFIPQYAALSYPYLIETHYDAVKATTGYLGNYWNEISKEKGGFEILGWTYSNFRYVTNSRRPVCNLEDIKGMKIRVPQNRVIIAAFDAWGANPVPMAWGETFTALQQGVVDGQENPYIVNHTMKFHEVQDYISETHYQYSLQPMIIGVNTLANMDDETREIITRAGIEAQQYGLLFQVLEAEKAKEAMQAEGVEVCELEDEDKWREIAMEKVWPEYYDFVGGKEVIDTMREHLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP93</accession>
    <name>D6SP93_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869889.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1941"/>
    <dbReference type="EnsemblBacteria" id="EFI34569">
        <property type="protein sequence ID" value="EFI34569"/>
        <property type="gene ID" value="Dthio_PD1941"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="205"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="321" mass="34965" checksum="F723D267720E2209" modified="2010-08-10" version="1">MPRNIALLSVLASLLTLGLKFGAFWVTGSVGLLSDAVETLVNLTASIVAVIALTVAFKPANRKFNYGHDKAEYFAGGLEGGLILVAAAGIIYSAVGRLMQPQALENLLLGIGISVVAALINLVVARIMLRAARHFDSITLEGDARHLMADVWTTTGVVLGLGIIMFYPQLVILDSIIAVIIALNITRSGISLIKRSMHGLMDVSLPREEVDLVEKHIRRHAGEKAAYHGLRSRKSGSRRFIDFHLLLPGDRTIREGHDICCRIEEGIEQELPKSQVTIHVEPEEDRASWDGDQVGGRKSSSESRHCEPGNESKEQNPGEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPB0</accession>
    <name>D6SPB0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycine betaine/L-proline ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869906.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1958"/>
    <dbReference type="EnsemblBacteria" id="EFI34586">
        <property type="protein sequence ID" value="EFI34586"/>
        <property type="gene ID" value="Dthio_PD1958"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="25"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="341"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="397" mass="44011" checksum="E97A00596EB4E4DD" modified="2010-08-10" version="1">MEKIVINNVVKIFGDHPKKALELLRQGEPISQILDKTGNVVGVADVSFTVNEGEIVVVMGLSGSGKSTLVRCINRLFEPTAGEIYVDGQDVCKLDTKELRDFRRRKFGMVFQNFALFPHRSVINNVEFGLEVQGADKGEMRQKAETALEMVGLKGWGEKYPSELSGGMQQRVGLARALALDPDILLMDEAFSALDPLIRRDMQDELINLQQKMQKTIVFISHDLDEALKIGDRLVILKDGAVVQIGTPEEILTRPATEYVRKFVEEVDITKVLTAESVMKKCEDVAYLGSDGPNAAMRKMKKNAIASLFVLNKDRTLAGIVFAGEVRRLVDEGESDLEKAMHKDIKMVSRDTPAQELFPIMQDMSYPVAVVDDENKLLGIIVKGLLFSAIAERGGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPE0</accession>
    <name>D6SPE0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable endonuclease 4</fullName>
            <ecNumber evidence="9">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nfo</name>
        <name evidence="11" type="ORF">Dthio_PD1988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869936.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1988"/>
    <dbReference type="EnsemblBacteria" id="EFI34616">
        <property type="protein sequence ID" value="EFI34616"/>
        <property type="gene ID" value="Dthio_PD1988"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1088517at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
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        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 9 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="10">
        <location>
            <begin position="31"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="290" mass="32071" checksum="ABD2D069015B9F9D" modified="2010-08-10" version="1">MNAARYLGAHCSVSGGLYRAVERIEGLSGTALQIFTRNQRQWKTSPVKEQEAEQFRQALQQWGDYPVFSHDSYLINLASPDREILKKSVQAFAGELKRCALLGIPGLVTHPGAHKGQGLDKGLQAYVRALDEALDLALQQCPESADVEVLLETTSGQGTVLGSTFQELDFIISTSKNSDRLGVCFDTCHVFAAGYDMRTRESYNATMQTLDSTVGLQRVQAVHLNDSSYGLGSRGDRHEHIGKGEMGLEPFRLVLNDPRFYDVPMVIETPKDKAGKWDLANLNLLRGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPJ7</accession>
    <name>D6SPJ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869993.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2045"/>
    <dbReference type="EnsemblBacteria" id="EFI34673">
        <property type="protein sequence ID" value="EFI34673"/>
        <property type="gene ID" value="Dthio_PD2045"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018476">
        <property type="entry name" value="GlyceroP-diester-Pdiesterase_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10110">
        <property type="entry name" value="GPDPase_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="350"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="602" mass="67186" checksum="5BD3D10E87A4A98F" modified="2010-08-10" version="1">MQIKKQASNIISDLGRCFRPLFIYHIFFSILAVMLLAPASAWITTKVLTTTGHPMISHQEMLDFFLSPAGLAWVLAGGTLTVLIVFIHHAGMIYISSRSCSGRYRLASSALVRVGRNLPSLLALALIQVAAHLLIAAPFIIVMGLAWLILLGDYDPYFLISQKPPIFWIYCAVCTPVALGMLVCNGILYLRWFMALPIVLLEGAGPWNALRRSSGLARGWIKPVAVLVLGLALLILTLPGIIAVLFDTLGGLFLGLLPENFTVLVPAVLFFTSFYIVLAVMLSFAGTAANSLLVFNVYKDTTGFEPFRESVFAPRRSRILAWSAELVLLVFALVQAGFIVHSFFDFQDHVYISAHRGSSMLAPENTIPAIERAIVDGADYVEIDVRLTADKVPVLLHDRDLRRVAGKPVPIWELDLKEVQRLDAGSWFHPRFAGVGIPTLEEVIEVVGDRARIYLEIKPSRHTPDLTRIVVELLQEKDYVDQVLLGAMDPEVLKEARNLEPELRTSLFVHTAIGEPDRSLLDALGLRAAITTVEDIQRAHRHGHELHVWTVNDRREMSRFIDMGVDNIITDRPEVLAELLRERAELSNAELLLVKLRHWLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPK5</accession>
    <name>D6SPK5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">Dthio_PD2053</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870001.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2053"/>
    <dbReference type="EnsemblBacteria" id="EFI34681">
        <property type="protein sequence ID" value="EFI34681"/>
        <property type="gene ID" value="Dthio_PD2053"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="118"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="237"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="389" mass="42612" checksum="F64D02E65F938548" modified="2010-08-10" version="1">MIGSQGKYFFTSESVSEGHPDKVSDYISDAVLDALLENDSESRVACETLVTTGMVFIAGEITSQGYADLPGIVRETVKDIGYNSSDMGFDWETCAVISSIDKQSPDIAQGVERKSPEEQGAGDQGMMFGYACTETDALMPAPIHYAHKLSRRLAFVRKKKVLDFLRPDGKTQVGLEYENGRPKRIDNVVVSAQHDPNIAYQDLSDAIKKEVIFHTLPPELMDEKTKIYINTTGRFVVGGPMGDCGLCGRKIINDTYGGMAAHGGGAFSGKDPSKVDRSGAYMARYVAKNVVAAGLAERCQVQIAYCIGLAEPVSVLATSMGTGQVDDETLTKAVREVFDLRPYFISKRLDLKRPIYQMTTNYGHFGREKPEFTWEKTDAAADLKTACKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPS5</accession>
    <name>D6SPS5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2127"/>
    <dbReference type="EnsemblBacteria" id="EFI34751">
        <property type="protein sequence ID" value="EFI34751"/>
        <property type="gene ID" value="Dthio_PD2127"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9279" checksum="CB283E2B04BC9DDC" modified="2010-08-10" version="1">MDKSQAGQLIRETFESPFDKDRFKAFVKNLLNTVEDAPFIYRGKFIPDANVKEAIQLWIDTAREFGDPVPEPKGRRLMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPT8</accession>
    <name>D6SPT8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870082.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2140"/>
    <dbReference type="EnsemblBacteria" id="EFI34764">
        <property type="protein sequence ID" value="EFI34764"/>
        <property type="gene ID" value="Dthio_PD2140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="461" mass="51457" checksum="2CF6CF0A7C4FCA46" modified="2010-08-10" version="1">MIRILFFATLEMVAPLHIGSGKKDDPLSDNPVMRNTAGMPFIPGGSLSGLFARILDEKQKIDLLGYPSSHKKGDNKPSRVTFDDALPIPQQQYSILHPVDVRTSVTIKRDTLTAKQNHLFQSEVLPVGTRFCFSCRFDAENEEQASEFRELVNTFLNMSPPLGGKTNSGKGQWKADEFHIARFDLSTPEGVREWVLKGHGFNWTGDPSTLDFSSKEKNIPVQNLGDERWRVRIQAEIDGLHLVAAMSGVPVKESPDIEQATRQRIDDQGVLQPEYVDFGSSVKGQLRTIMEMILRTHLKSHGLSKKQVEQELIPDPAPGQKDPKSKWVNAAQFFGSTEKKGGFRACEMVWHDADISREDHIRLCEFTQQTISGAKFEFAPLCKGRSELEISVPKDSPDWQKELLSHAAILLSLDILPFGGHASRGYLGAKFSSPEYPDGKPAQGELKSLVESRIHEKQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPU4</accession>
    <name>D6SPU4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870086.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2146"/>
    <dbReference type="EnsemblBacteria" id="EFI34770">
        <property type="protein sequence ID" value="EFI34770"/>
        <property type="gene ID" value="Dthio_PD2146"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1089680at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018704">
        <property type="entry name" value="TPR_21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09976">
        <property type="entry name" value="TPR_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_21" evidence="3">
        <location>
            <begin position="203"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="466" mass="53877" checksum="595CD28C99FF2304" modified="2010-08-10" version="1">MSNAQAKIIHTPHFNSGLAEKQEDSQENFVDNEVQEGAAFLEDLAGQAQVQEQLRLRQKSCMAEMALLRQENSWEQILDMFYPLEDKAPELVASELDMELRMELAFVLGQVNRFDEAVREYEVCLQVQPDNYFANSGLAYTLYNSLYAAQNREILLTPDGKKHRAEKAHKHFEKAQEIRPEGVTNYYRQGMLYKNLQNKPALGLPLFARAVTNWRGYSPQQQKARHQEHKNYIKALYNLGSCRLKLNQAQMALKNIQECIQEDQKHYISAVNKYFALGKVCYSLGEFSQAREALEFAATMADVKDGDYVYEMLGRVLLSLEENEKALEAVRKVPFKLRKPYVRWTEADILVAVGQTQEAVQVLTHALNKDRRSRHKTLIRLCRIHFGQKDYQQSLQQAREADDFHRQTFNSPDADALFWQSACHLHLNEVEQARQKAQDLSDFSPGYPFLKKLVKAIEKAEQKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPU7</accession>
    <name>D6SPU7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ORF">Dthio_PD2149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870089.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2149"/>
    <dbReference type="EnsemblBacteria" id="EFI34773">
        <property type="protein sequence ID" value="EFI34773"/>
        <property type="gene ID" value="Dthio_PD2149"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10650" checksum="C28B78AB2C7B1A86" modified="2010-08-10" version="1">MFCLVCFDIVDDKVRYKAAKVLKGYGYRVQKSVFECPELTEKQYLKLKDRLENLIDATEDSVRYYRQCRACLGEFEFSGIGEAPSADEYGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPW1</accession>
    <name>D6SPW1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870103.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2164"/>
    <dbReference type="EnsemblBacteria" id="EFI34787">
        <property type="protein sequence ID" value="EFI34787"/>
        <property type="gene ID" value="Dthio_PD2164"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1093321at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="549" mass="63619" checksum="0FB6B36ECF3DA7A7" modified="2010-08-10" version="1">MAYSSGQENINQLLERAKAASGQDDREKALSLYRQAVKAAPNLVMARTGLAWEIVKSLKEQKNNDFPNPQHFLDLLREYACIHDIKKPGRLHSQFLRWAANAAAKEKISNFISILRWWDPANFRLEDFERFRPDGGDRSFDSLVELAIRGIAKNIKKENDQYHLDWATEFVGQHYDKYPHQEWFPHYYSKLLIKTGRMAQARELLLPLVRKKQNEFWSWTHLAQTYPGDNDTRLSCLCRALLCPAKEEKYRVKVHEELAEILVEKEKLPEARYEIEQAINIQESNEWKVSAKMQLFRSSPWFSQVQVLNSNRQLYQDHSSLAEEIVFHGLPVHPAIVIKHLPEKDKRPGLTFMGFTREGSLEQVLIKTKKFPVLNNMPPGTPLSLSLELSGQEPVVINLEPREGESWDIIEPRPGVVKNINTGKGITFVALSSDEFCPVYHDSLPEIRSFEPGDGLNIRTVSEKDMKQRVVWIGKKEELPSFARRFSGSLNLKGWADFGFVDEVYIPRELVGRWELKNKDELQGVALMEYNPKKEQYGWRAVSLYRKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPZ3</accession>
    <name>D6SPZ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2204"/>
    <dbReference type="EnsemblBacteria" id="EFI34819">
        <property type="protein sequence ID" value="EFI34819"/>
        <property type="gene ID" value="Dthio_PD2204"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="1">
        <location>
            <begin position="57"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="2">
        <location>
            <begin position="396"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="567" mass="65409" checksum="CA492D8DBCC1DB41" modified="2010-08-10" version="1">MLHAKNRMQPYLPINVTYFNDRKYDYLQKTIYHTFRTVFLPFLPVKIYGKHFDKTMGRKTKDVQSMLGLFILQALFDLKDSDAVEAYTFDQKFHYALDIKEQEAYLSARAFYYYKTILLGTEDHIFEQILAKIFDELQFDYSLQRTDSSLVRLNLKKMSQWELFKKTLIKALNDIKAKHPVIFKSVPEHIQQYIQNDENNTWFSDFTPSKANDYLVQAARDALELKELFESHPKISKLESFQLVQRLINEQVDVDDQGQIKVEIKEECKGSAMANPHDPDAQYNGHKKDIGVKLNTSETCAPDKDTPNPQIITHAEVTPANISDHELLQPSIDAREEKGFKPDVELTDNGYESDANHQALQEKGVDLIAPPTGKPPEGFGVMDFELQENGQSIDACPMGQTCIENKINQKKQKTASYFDPEQCRACPHSEDCPIKITKRKAKVEWQWSKPRLEARRHAFQEDQELINLFKQRAGGEAGFSQLKVNLGLRRLRCRGSVKSKFKIIMAVTALNIKRAFNWMKGGSSGSRARNNKDFEPDTGILLFFFWLFCSYLRKILIVSGLRPKIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ16</accession>
    <name>D6SQ16_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisI</name>
        <name evidence="9" type="ORF">Dthio_PD2233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870156.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2233"/>
    <dbReference type="EnsemblBacteria" id="EFI34842">
        <property type="protein sequence ID" value="EFI34842"/>
        <property type="gene ID" value="Dthio_PD2233"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1842189at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="125" mass="14494" checksum="327DAFE80DD92BC6" modified="2010-08-10" version="1">MKPDFDKGNGLLPVIVQEWETGEVLMLAYTDEQAWEKSLDTGEAHFYSRSRKSIWHKGGTSGHVQRIREIRIDCDYDTILFMVEQVGGAACHKGYKSCFYTRVEKDGRFLEHAEKVFDPKEVYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ63</accession>
    <name>D6SQ63_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870203.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2280"/>
    <dbReference type="EnsemblBacteria" id="EFI34889">
        <property type="protein sequence ID" value="EFI34889"/>
        <property type="gene ID" value="Dthio_PD2280"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="238"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="379"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="637" mass="72132" checksum="8397D897BDAF258F" modified="2010-08-10" version="1">MQDKDSTEQIKDLQARLEHQEEINRFTLDALELAASLIDFQPRISSLESPSLILDEICNRIARLIDFQALGIYLVDEQDNDFYPAYMTPAKYNEALAQETGRLIDKGFFPWAMREKRPVILAGSCKDRNIVLHVLSTSARVRGMFVGLIGSEVHTVPDVSWGLLTIVLSSSANQLESFELYKLFRESNIHLKKIVQERTKQLEAQASYDRLTHLPNRDMIFKNLEKQIRWCLHTNDQCQAAFILVDLDMFKEVNESLGHQTGDRLLVQVGERLQELTDDCEILGRLGGDEFALVFTGNDVRKQATKRAGQMIQAMARPFELQGQSLLLDVSIGIAIFPEHGKTLGQILSRADMAMYAAKRMKTGYAVYDPKFESSGINRLNLMSELKKGLQHDQLSLYFQPKINLHTSRVCGVEALIRWHHPTRGFISPEEFIPLAEQGGLIRELTSRVIRMSMEHLQHWKAIGISIPVSINLSVRDIQDNNLPSQISSAIENHALDASCLELEITESAFMSAPQKGLRVLKNLDSLGIPMGIDDFGTGYSSIAYLRDLPVKIIKIDRSFVMDMDSNDNNRKIVKSIIDLGHNLDLQVVAEGVESRTSLDMLKELGCDMAQGYFILKPRPFDELTDWLQKKTDLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ83</accession>
    <name>D6SQ83_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870223.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2300"/>
    <dbReference type="EnsemblBacteria" id="EFI34909">
        <property type="protein sequence ID" value="EFI34909"/>
        <property type="gene ID" value="Dthio_PD2300"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1305123at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="218" mass="24896" checksum="B2D6552C58363263" modified="2010-08-10" version="1">MDDRREQLSLFGRVRKFLKVNILAGILFLAPIVATFFILKVTIEWIDRILLIIPPAYRPENFMPFPVPGLGLILLLLVLIFSGMFVRNYLGKKLVYIWERIVEHIPIVNKIYTAVKQLLDTIARGTAKDFKRVVLVEYPRQGMYAMAYVTGVAVGELQEKTKRRMVNVYVPTTPNPTSGFYLMVPEDETIPLDMSVEDSFKLLMSGGILTPEKKDEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQA4</accession>
    <name>D6SQA4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase RecJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870244.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2322"/>
    <dbReference type="EnsemblBacteria" id="EFI34930">
        <property type="protein sequence ID" value="EFI34930"/>
        <property type="gene ID" value="Dthio_PD2322"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="2">
        <location>
            <begin position="28"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="353" mass="40745" checksum="DCAA537FF0174944" modified="2010-08-10" version="1">MAYFRTLENRLVKLQGLFKKKERLLIMINADPDALASALALKRLLYRKVHSVGIAHVNDISRPDNLEMIKLLRIPTKRFSPALLPHYDRFALVDSQPHHHKDLARVDYSVVLDHHPLDKENPVQADYQEIIPEYGATSSLLTEYLYNMKIRPGKLLATALVYGIKTDTQSFERKFSDVDIRAFRHLTKFYEPLLLQNIIRSEFHREWLKYFSLAFRKIRFMGNGASVFMGKVDSPDILVILADFFLRVHNISWDIISGIHEDRLVIIFRGDGLRKDMGKLCTQMFKDLGPAGGHKQMARAEIPIEKIDQKHAQQFILQRLADVRNKKKKTSRTANSNRKENSAGKTNNDPGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQA8</accession>
    <name>D6SQA8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870248.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2326"/>
    <dbReference type="EnsemblBacteria" id="EFI34934">
        <property type="protein sequence ID" value="EFI34934"/>
        <property type="gene ID" value="Dthio_PD2326"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="150"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="405" mass="45394" checksum="79652286F9BBCA73" modified="2010-08-10" version="1">MFESLEKLPAEEMQQRIEAFRNNIRSSGLDCEAAMIFSRLNIYYFTGSFGNGLLWIPMEGDPVFMCRKGLQRFSLESPLERVVSFKSFGQVPGILSDFHLSIPKRLGAEKMGLPWGLADNLQKRLTGPEFVAVDQALSLTRMVKTSWEAEKMQLCGRRHHYALYHLLPEMINPGMTEREISMKVWECFFSQGHQGLMRMQNFGEEIFLGHVAAGDSANYPSVFNGPVGLRGEHPAITQMGYAGKVWQEDEPLTLDCGFALEGYQTDKTQVYFPGRWDPPREVMQAHELCMRIQEEVAKRLKPGNTPSKLYLMAAEMAEKERMSQGFMGLGGNKVPFLGHGIGLAVDEYPPLAKGFDQPLQENMFLAVEPKIGIPGTGMVGVENTFQVTSRGGECITGDSFEPVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQB5</accession>
    <name>D6SQB5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane lipoprotein carrier protein LolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870255.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2333"/>
    <dbReference type="EnsemblBacteria" id="EFI34941">
        <property type="protein sequence ID" value="EFI34941"/>
        <property type="gene ID" value="Dthio_PD2333"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933827at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088024" evidence="2">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="212" mass="24392" checksum="BA3DB4673DC1BB86" modified="2010-08-10" version="1">MKRIIILSLTLILCFALPATASDQEVVDRVQDRLDALEGLKADYVQILTNAATKETQERTGSIYFKKPLQVRWEADAPHQELLVIDQDKVWNYFPDDEVAYEYEVEEVLTSRAMINFISGQAKLTEDFQVEEQGMEDGLHKLKLVPASPEPDLVLAYLWSDDQGLLHRILLVDFFGNGNELRLESMETDPELDREKFEFSPEDVEIREGRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQC7</accession>
    <name>D6SQC7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly PilZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870267.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2345"/>
    <dbReference type="EnsemblBacteria" id="EFI34953">
        <property type="protein sequence ID" value="EFI34953"/>
        <property type="gene ID" value="Dthio_PD2345"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZFS3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932769at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="16042" checksum="975BDE76E031845C" modified="2010-08-10" version="1">MSDFFGEFNFDYETGTRRRAYRISIPGLYVRIRGLEHAFPVQDISATGVAFENTYRQHLDYQPGDEMELDLLIKDRTYLEELKALLVRHRDFMLACEFHDLGLRQEAGLDKLVLEVQKKWIAAKKKKRAEEKNEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQL4</accession>
    <name>D6SQL4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metXA</name>
        <name evidence="5" type="ORF">Dthio_PD2434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870354.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2434"/>
    <dbReference type="EnsemblBacteria" id="EFI35040">
        <property type="protein sequence ID" value="EFI35040"/>
        <property type="gene ID" value="Dthio_PD2434"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="536745at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="56"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2 3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="390" mass="43308" checksum="B9A5F0EE2D63E83F" modified="2010-08-10" version="1">MSRGSEIPHSSVGLVETQSVTFRGAEWVLQLESGKTLHPVTVAYETYGRLSPQKDNAILVCHALSGDAHAAGYHTGKPGEKPGWWEMLIGPGKPLDTDRYFIICSNFLGGCKGTTGPADIDPATGRPYGLNFPFYTVRDMVQVQKWLVDYLGIHRLLAVIGGSLGGMQALQWPISYPEMVLGAIPIAATARMSPQAIAFNEVARQAIMSDPSWNYGLYKPDQQPESGLALARMIAHITYLSENAMLRKFSRRMIDGTERGFKLGADFQVESYLHHQGSTFVKRFDANTYLYITRAMDYFDLHLDYGSLKNAFEPCKSSFLVISFTSDWLFPPSQSQELVKGLRQADKNVSYCNIGSDQGHDAFLLPGNRMGDVVSGYLTRLEREDRRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQR3</accession>
    <name>D6SQR3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CMP/dCMP deaminase zinc-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870403.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2483"/>
    <dbReference type="EnsemblBacteria" id="EFI35089">
        <property type="protein sequence ID" value="EFI35089"/>
        <property type="gene ID" value="Dthio_PD2483"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1544522at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17009" checksum="9DA00D847CC1B901" modified="2010-08-10" version="1">MQQRLSWDQYYMRITHLVSRRSTCLRRVVGAMAVKDKRILATGYNGAPAGLEHCQDVGCLRDEMGIPSGERHELCRGLHAEQNVIIQAAIHGVSITGSFIYCTTQPCLICSKMLINCGVKKIYFSQGYPDPLAQEMLTMAQVEFELLEIVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQR7</accession>
    <name>D6SQR7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870407.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2487"/>
    <dbReference type="EnsemblBacteria" id="EFI35093">
        <property type="protein sequence ID" value="EFI35093"/>
        <property type="gene ID" value="Dthio_PD2487"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="247" mass="26803" checksum="7D389BE3861292B0" modified="2010-08-10" version="1">MSELLKTALVTGGSRGIGRECALRLARDGYNVYITYVSKPQQARETCTEIENLGVQAASFELDVGDQEAIVDFFKNEIKDRVDLQVLVNNAGLTQDGLLVRMKPEQWEKVIRVNLTGSFICLQQAAKIMMRNRRGRIINLSSVTAQTGNPGQANYTSAKAGLIGLTKTAAQELAPRNITVNAVAPGFIDTDMTDKLPGDVRDRFLQMIPLQRFGTPGDVAECVAFLASGEAGYITGQVLGINGGLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQS5</accession>
    <name>D6SQS5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870415.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2495"/>
    <dbReference type="EnsemblBacteria" id="EFI35101">
        <property type="protein sequence ID" value="EFI35101"/>
        <property type="gene ID" value="Dthio_PD2495"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="250"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="501"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="622" mass="69215" checksum="663E49C59BB1B0A1" modified="2010-08-10" version="1">MPREVFSRPSFKKAAGEDSFPAAEKNPARDAFMPPSRKSSRKLRSQVEEIVSTYQDSMAAFQRFRKCCSIVHSTTTLARLPGLLQSLKKELRLDGIHLVLASEEYDGLVPDSVTTMPQSGLHKLRAVLDLDHFSGCTIHSAEDLRASGLLEDLGFTPQGSLRTGSAIVFSLHDRFRSQRPVGLLMFYDRDSNRYTREVATDFVEHFAETFAWAMVSLRDHEKLRIQEQNLAAAKNEAEEATSAKSMFLATMSHEIRTPMNGVMGLSQLLLETPLNTEQRHLAGLIRSSGENLLDIINNILDFSKIEADRLVLEQVDFDLRTMMDEITHIMKINAGEKDIDFVSRIDPALETSLQGDPGRLRQILFNLSGNAVKFTAQGGVRLEVSPLTKLEKSIQILFEITDTGPGIDQETKNRLFTAYQQAESSTSREYGGSGLGLSISKSLVELMHGEIGLESSPGTGSTFWFKVWFGLQEKTTHDSWQPKQASEDPAPENPAVNTGIRILIAEDNSVNQLLATKVLEKNGFHADVVSDGRQALEALQKKHYHLVLMDVQMPVMDGITAIRSLRTGQTRVLNPEIPVIALTAHAGEGDRERFIKAGMNDYLPKPIMPDSLNQIVQKWATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQS8</accession>
    <name>D6SQS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870418.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2498"/>
    <dbReference type="EnsemblBacteria" id="EFI35104">
        <property type="protein sequence ID" value="EFI35104"/>
        <property type="gene ID" value="Dthio_PD2498"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="219" mass="24308" checksum="8490DAEDA4C615FF" modified="2010-08-10" version="1">MNRLDPYSAIAPLYDLAVTPFLHRIRKTICTRLKTLQAEKVVDLGCGTGRQLRLLSRYGFQACGVDFSAAMLKKAAGFSPRTVVVQADLTSTPFSSRSFDCALLCLALHENPWPVQKQIMAEALRITRPAGHVVILEHALPLGVCGRITSLPAHIPERLAGKKHYQYYQEFIKKGGLHGLLMSWPGLQTVGTEYFYLGNLVLIKVKKIETKTAEKLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQT8</accession>
    <name>D6SQT8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870428.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2508"/>
    <dbReference type="EnsemblBacteria" id="EFI35114">
        <property type="protein sequence ID" value="EFI35114"/>
        <property type="gene ID" value="Dthio_PD2508"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="13734" checksum="3B58B7A67174A9F9" modified="2010-08-10" version="1">MAKHILMVDDSKTVRNLIAFIVKKEGFHVTTAEDGLDALEKLYAASNVDLIITDINMPRMDGFTFVQNLREQEAFRDVPVIILSTEGQEKDKEQGLSLGANLYMVKPAQPEWLLKNVKMLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQX7</accession>
    <name>D6SQX7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, Csd2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870467.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2549"/>
    <dbReference type="EnsemblBacteria" id="EFI35153">
        <property type="protein sequence ID" value="EFI35153"/>
        <property type="gene ID" value="Dthio_PD2549"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="598606at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013418">
        <property type="entry name" value="CRISPR-assoc_prot_Csd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02589">
        <property type="entry name" value="cas_Csd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01595">
        <property type="entry name" value="cas_CT1132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="291" mass="33128" checksum="F80207609D093C5E" modified="2010-08-10" version="1">MTAIQNRYEFVYLFDVENGNPNGDPDAGNMPRIDPETGYGLVTDVCLKRKVRNFVDIVKNNEPGFKIYIAEKAVLNQTNEMAYKALDLKPEKKKLPKKWEDARKVTRWMCDNFYDVRTFGAVMTTEVNCGQVRGPVQLTFARSIEEIVPAEVSITRMAVTNERDLEKERTMGRKHIIPYALYRAEGFISAHLADGDKGTGFSEADLNLLWQAMENMFDHDHSAARGKMNARRLIIFKHDSKLGNAPAHKLFDLVKVERATDPEKPPRSFSDYTIAIDQANIPQGVTLEQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR64</accession>
    <name>D6SR64_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0504"/>
    <dbReference type="EnsemblBacteria" id="EFI33180">
        <property type="protein sequence ID" value="EFI33180"/>
        <property type="gene ID" value="Dthio_PD0504"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025639">
        <property type="entry name" value="DUF4338"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032806">
        <property type="entry name" value="YbfD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13808">
        <property type="entry name" value="DDE_Tnp_1_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14236">
        <property type="entry name" value="DUF4338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4338" evidence="4">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1_assoc" evidence="3">
        <location>
            <begin position="220"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="370"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="598" mass="68729" checksum="9C0F0554E66523E9" modified="2010-08-10" version="1">MHTKPRPSYLLSVRLQPIKREQESLFKSLMAKHHYLGASPKISETLWYVATYSDQWVALLTFSAAALKCAARDRWIGWEYRHRFDRLKLLANNTRFLILPGWNLPNLGSRILSLCAKRISFDWQQHFGHPLLLLETFVDPRRYTGTVYRASNWTELGLTKGFKRVGQGYSAKPSSPKLIFVLPLQANARKLLSCAILNPAYQKGEPKMTMNAKQMESLPDYFKTVTDPRRTHGRRHRISTVLSIAAAATLCGMKGYKAIYGWANKLGQKARQRFRCRKENGKYVIPSQFVIRDVLVRADPVELDLAVQRFNEDQGLEDTCLAFDGKTMKNAIDENARQTHIASVVGHESKTTHTQKKVGALPAEDDDQETKQTNEIGMFIPILEQIEVSGKTITADALLTQKKLAEYIVGRNAAYLFTVKKNQPTLYFDIKNYFEHRKEPDYCLQDPPGHGRIDTRSIWTTTELNEYLEFPHVGQAFCIHKKSYDPKTNKVCENTFYGVTSHHPNKADPARILQIHRGHWSIENSKHYILDWTYDEDRNRIRTGNGPANTNRLRGFAIGLLKSKGVKDIAQKVRDLHQQIRPVLDYFKMTKNSQKHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR67</accession>
    <name>D6SR67_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/carnitine/betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870541.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0509"/>
    <dbReference type="EnsemblBacteria" id="EFI33183">
        <property type="protein sequence ID" value="EFI33183"/>
        <property type="gene ID" value="Dthio_PD0509"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1217683at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018093">
        <property type="entry name" value="BCCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01303">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="520" mass="57518" checksum="28E06E5D74DA74C7" modified="2010-08-10" version="1">MEEDIQMPRQMRKSTWKKRTGKFRYDIHPWVFFVSTVIILLGVIVTLAAGDVALEAFGAIQGWITTHFGWFYILVMNLVLVFCIALIFTKYAGMRLGGEDAEPEFSIIGWFAMLFSAGMGIGLLFFGVAEPMYHYLDNPLGESESIEAARMSMEITFLHWGFHPWAIYAVVGLGIGFFGFSEKLPLSIRNIFYPVLGRRIYGPIGNFIDILATIATLFGVATSLGLGVQQINAGISHLTGIPENTFVQGLLIAGITAIALWSVLRGLDAGIKLLSQINIGIAAVLMLFVFILGPTLFILTGLLENTGNYLQNLPSLALWSEAYDEGGWQSAWTLFYWAWWIAWSPFVGMFIARVSYGRTIRQYLTGVLLVPVAVTFVWLTVFGNSAIYLEHFAEVGLADAVLANMPVSMFVFLEQFPLGMLTSILAVLVVITFFVTSSDSGSMVIDIINAGGNPDPPKIQRVYWVVLEGLVAGVLLVGGGLVALQTASLITGLPFAIIIFIMCWSLFKGLRRHWLKYYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRI7</accession>
    <name>D6SRI7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870661.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0629"/>
    <dbReference type="EnsemblBacteria" id="EFI33303">
        <property type="protein sequence ID" value="EFI33303"/>
        <property type="gene ID" value="Dthio_PD0629"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="35275at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="64"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="275"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="966" mass="107484" checksum="C955299841EC02CB" modified="2010-08-10" version="1">MPGVDELLQQMGQGDLQGLSTVAVKEIPAREAEFSGIEGLPPPLKQALTESGIENFYTHQARAVNLVRKGRSVVTATPTASGKSLIYNIPVLESIINDPASRALYLFPLKALTRDQLTSLEEFARLLAGKVHVDSAVYDGDTDPQARARIRSKPPNILLTNPDMLHRSFLPYHRSWQKFFSALKYIVVDEVHTYRGVMGSNMAWVFRRLRRICAQYGREPVFIFSSATIANPGQLCSALTGHEPEVIQKGGAPAGKKHFLLLDPEMQGAAQSAIRVLQKALELGLRTIVYTQSRKMTELIAMWASQRAGRLKKYISAYRAGFLPEQRREIEQKLASGELLAVVSTSALELGIDIGHLDLCLLVGYPGSVMATMQRGGRVGRSGRDSAIMLIGHEDALDQYLLRNPREFFSLEPESAVINPDNPSIMRRHLVCAAAEKPIALQEMMLDNEAGKCIKSLEKDGELLASRDRSFYYTRARYPHKDVDLRGTGQTYNIFEHSTGEYLGEVDGVRAFKETHPGAVYLHMGETYVVQDLDLETFAVYAAKSEANYYTRPITEKYTEIVEVQATRATAAGELCLGRLKVTEHVSAYEKRLVRGQARIGLIPLDLPPLVFETQGMWFTLDSQVRRDVEDRRLHFMGGLHALEHGLIGCMPLIILTDRNDLGGIASPVHEQLHKGAVFIYDGTPGGIGLCRQAFELGDRLVARAMGILSSCTCENGCPGCIHSPKCGSGNRPLDKEAAMHMLAVLAGERCGEAKRKDVSCRIETDEGSMEIDSGYTKSDQAELPYAVLDIETRYSAQEVGGWGNCHRMGVSFAVVFDSRNQEFVTFDQEQAADLGSFLEDFSLVVGFNLLKFDYRVLQGLSDYDFSSLPTLDMLREIEARLGHRLSLDHLARHTLGTNKSANGLMALKWWKEGELDKIVEYCRQDVSVTRDLYLFGRDKGYLLFKNKAGKKVRIPVSWQDTAFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRN5</accession>
    <name>D6SRN5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870709.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0679"/>
    <dbReference type="EnsemblBacteria" id="EFI33351">
        <property type="protein sequence ID" value="EFI33351"/>
        <property type="gene ID" value="Dthio_PD0679"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033BX6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025067">
        <property type="entry name" value="DUF4079"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13301">
        <property type="entry name" value="DUF4079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="141" mass="15980" checksum="C202191A747FCD78" modified="2010-08-10" version="1">MLWIHPILQALVTIGAFYVFYLGLQRFRSAHLGHRVPFNWKRHVVMGRWVIIGWLLGLAVGKMAVNAEMGMMGIFADHNQGAMVMTPLMLIAYVSGTYMDRRKARRTALPLVHAANNVLLLGVALYQVYTGWPIVENFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRX1</accession>
    <name>D6SRX1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870789.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0771"/>
    <dbReference type="EnsemblBacteria" id="EFI33437">
        <property type="protein sequence ID" value="EFI33437"/>
        <property type="gene ID" value="Dthio_PD0771"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZV8Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2084394at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="118" mass="13797" checksum="AB53079602835370" modified="2010-08-10" version="1">MIRQIYDSRFKELENVLLDEKLCMKYYGYIMKGDHMQRTTIMLPRELKIRAYSKSRKMGVSLGQLIREALQKEIDSTEAGNGLQDCFYADKAVYQGDSPPDFSAEHDEYLYGESHDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRX3</accession>
    <name>D6SRX3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870791.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33439">
        <property type="protein sequence ID" value="EFI33439"/>
        <property type="gene ID" value="Dthio_PD0773"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033BFW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2045422at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045944">
        <property type="entry name" value="DUF6364"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19891">
        <property type="entry name" value="DUF6364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8590" checksum="C8F837AC1EC7F236" modified="2010-08-10" version="1">MNITLSADKELIQKAREYAAQRGTSLNQLIREYLEHTAAMGDKESSAREFERLARECGGTSPEGYVFDREDAHARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRY9</accession>
    <name>D6SRY9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870807.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0789"/>
    <dbReference type="EnsemblBacteria" id="EFI33455">
        <property type="protein sequence ID" value="EFI33455"/>
        <property type="gene ID" value="Dthio_PD0789"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041699">
        <property type="entry name" value="AAA_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13654">
        <property type="entry name" value="AAA_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="568"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="658"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="805" mass="90203" checksum="C675285938F86E10" modified="2010-08-10" version="1">MTRKFQVPASRLSIKLSPSRIGFSHTGRAAARRDKKHVFQQRAFDALELTLAIKRSGYNAYLSGEKGLGRNRFILDFLRPRAGKMPAPGDLVYVNNLQDPDQPLAITLPPGSARDLRREMQAAIKKIRESIPAGFEQDFYIRKHGDLIKEYNETRENLLSRMEHKAHKSGFSLSVDENGSLTLYPLVEGRAMDPEEFEKLESEVRKDLMQQSNRIMEALLGLSRQISRKEQDLKDNERRLDREVAGGRIDTCLKKIRQKFPDNQKLMDYLESLKQDLLDNIDQFKPRDQSSESSQEVQVGGPDACLSRYGVNIFVEHCRNGGAPVLVEDNPNYFNLLGCIERETEMGAYYTDFTLIKPGSLHKANGGFLIIRAEDILAQPQAWEGLLRCLRSGRAEIEDPADQYEMVRTRTIRPEPIDLDIKIILLGSDELYEILLEADERFGKLFKVKAHLRESIPRTEESIRNQSMDLAEIAVSNSLMPFDREAVAALVDQSSRIAGDQQKLSLKYSHLADLMVEADAYARMHGADRVNADSVCQALKSRKYRLSLYEDEFMSEYEREAIKVQTQGSAVGRANGLSISMYGDYILALPHQISCTTGVGHGGIMDLEREAELGGPIHTKGMMIIKGYLQNLFAQEKPLVLSGSLCFEQNYAQIDGDSASGAELAALLSALSNIPINLSYAFTGAISQSGAVMAVGEVTRKIEGYFELCRRKGLTGGQGVIIPRDNLTHLMLSREVIQAVKDNMFQVYAVTCIEEAMEILTGTRAGKKLADGKYSPGSIYRLADERLQHLAHLADKQVPGKRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS64</accession>
    <name>D6SS64_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylacetyl-CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20956"/>
            <dbReference type="ChEBI" id="CHEBI:18401"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57390"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylacetyl-CoA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870880.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0864"/>
    <dbReference type="EnsemblBacteria" id="EFI33530">
        <property type="protein sequence ID" value="EFI33530"/>
        <property type="gene ID" value="Dthio_PD0864"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="UniPathway" id="UPA00930"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006444">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="79"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="333"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="433" mass="49069" checksum="9C24375443C68E93" modified="2010-08-10" version="1">MQVFDRHEVLDRKEIENLQAIRLKNTVHQATASTFYRNSLARASVKVPDINSHEDIARLPFTTKEDLREQYPFGFLAMPKEKMVRLHASSGTTGSPTVILHTQNDLNVWADLVARSMHCAGVRSSDVFQNMSGYGLFTGGLGIHYGAERLGCLTIPAGVGNSKRQIKMLGDYKVSVAHIIPSYALHLGSVFDDQGVDPRSMHLRIMLIGAEPHSEEIRSRIQEIYGVRAYNSYGLSEMNGPGVAFECEYQTGMHLWEDAYLAEIIDPETLEPVPQGQTGELVLTTLTREGMPILRYRTRDLTRFIPGECPCGRSHRRIDRITGRSDDMIVIKGVNIYPMQVEKILMSIPEVGQNYIIQLERQGHMDQMRVKVEIRDEFFVEDMRRLQQIQNKIAGLLREEILISPKIDLVEHNTLPQSQGKATRVVDKREEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS66</accession>
    <name>D6SS66_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870882.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0866"/>
    <dbReference type="EnsemblBacteria" id="EFI33532">
        <property type="protein sequence ID" value="EFI33532"/>
        <property type="gene ID" value="Dthio_PD0866"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1462872at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="213" mass="23126" checksum="1A9CA29EF815D720" modified="2010-08-10" version="1">MQERVSPALICLACIFAGSLVIAAVISSKIISVGPIVVPAGILAYCLTFVASDVISEIWGKNTARQVVAGGFAALVVCLGLIHLALAWPAAPFWEGGQAFEEVLGAAPRIILASLAAYIVSQYHDVWAFHFWKKTFRGRHLWLRNNLSTAVSQLLDSTIFICIAFLGVMPLLPLILGQMAVKLIIAFLDTPLVYLLVWLLKKPSSQEKYSTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS84</accession>
    <name>D6SS84_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870900.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0884"/>
    <dbReference type="EnsemblBacteria" id="EFI33550">
        <property type="protein sequence ID" value="EFI33550"/>
        <property type="gene ID" value="Dthio_PD0884"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="376209at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="453" mass="48482" checksum="FEFCB9FD3FA15CD8" modified="2010-08-10" version="1">MQDLNFRESWATRIGFILAASGSAVGLGNIWRFPYMTGEHGGAAFLVIYLVAIILIGYPVMINEVILGRKTNKNPVGAFKALAPNTPWWLVGALGVFTGFVILSYYSVVAGWSLAYIYKVVLSATAAEIDHAEVFVGHITSVWEPIIWQAIFMILTVSIIAAGVVKGIQKWVTILMPAILVLLVILIIRAVTLPGAGEGLAYYLQPNFGDVGPRTFLGAISQAFFTLSLGMGAIITYGSYLREKDEIPGNSASVVGLDTGIAIMAGLAIFPAVFALGFSPDGGPGLVFITLPAVFAEMPLGVLFGLLFFILLSIAALTSAISLLEVVTAWLIDEKGWTRGSAAVTMGIIIFVVGLPTTLGYSVLSDVTFPGLGMDMLDTYDWFANSIFLPLGGLLTAIFVGYIWGARNAVQEGNKNAGLISLGNWWVLLIRYVVPALILVIMIMGIYDTFFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSA1</accession>
    <name>D6SSA1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Quinolinate synthase</fullName>
            <ecNumber evidence="3">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870917.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0901"/>
    <dbReference type="EnsemblBacteria" id="EFI33567">
        <property type="protein sequence ID" value="EFI33567"/>
        <property type="gene ID" value="Dthio_PD0901"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="613347at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="355" mass="39457" checksum="FA0E8001F77889A3" modified="2010-08-10" version="1">MVEKNARALDSEVIKQYLPQGKTIEELEEDMAPKSRQELKDRIKILLREKDAVLVAHYYVSAELQELAAETGGFTSDSLDMARFGNEHPASTLVVAGVRFMGETAKILNPEKKVLMPDLDATCSLDLGCPAEDFATFCDEHPERTVVVYANTSAEVKARSDWVVTSSIAEKVVRHLHEKGEKILWAPDKYLGDYVRQQTGADLISWDGACVVHEEFKAEALKQMRLDIPDAGVLVHPESPREVIEQADVVGSTTQIIKAAKELPNKRFIVATDRGIFHKMRQAAPGKEFVPAPIAGETVECIACAHCPWMAMNGLQNLAHTLETGENEIHVDPETGRRARVAVERMLEFSRNLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSA5</accession>
    <name>D6SSA5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870921.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0905"/>
    <dbReference type="EnsemblBacteria" id="EFI33571">
        <property type="protein sequence ID" value="EFI33571"/>
        <property type="gene ID" value="Dthio_PD0905"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1401825at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021147">
        <property type="entry name" value="DUF697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05128">
        <property type="entry name" value="DUF697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="408" mass="45972" checksum="FA078FDE2F9E0C39" modified="2010-08-10" version="1">MSKKRQVLIGDPLDQVPEGREQESREQKDQDARQVEGSGKTGNETSDAGYRRRDSGLGQPDPEPGRDHDVRDVSPEEMQELRREQEKLKRQLEEKMLDLERTGIRIPRVIYRTALWTAVFLGAVLGLFLVSQGVRFAGQVAALNMPWNILAVSGFALFSAMILMVIIKLAGRFLAFRSLSKVDINALKMLAQRRRFRWLAQQKQDEAREVLAGYLKDYKVKDVDADTLGLDRQELARIDSYRQNLLDSYGHLDSATWLKQMDETFVHALDRAANRRIRLYSRNVGLGTAASPIKFIDQLIVLYASLKLISELLQIYNLRPAMGQSLTILARSIIQAYLSGIIGEHSEAGVETFGDYYESIFGEISFATGVSAAADATRYALPKAGEGALNGFLVWRLGRHARRMVRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSC6</accession>
    <name>D6SSC6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">glmU</name>
        <name evidence="17" type="ORF">Dthio_PD0927</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870942.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0927"/>
    <dbReference type="EnsemblBacteria" id="EFI33592">
        <property type="protein sequence ID" value="EFI33592"/>
        <property type="gene ID" value="Dthio_PD0927"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="16">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="20"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="267"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="401"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI33592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="474" mass="51101" checksum="97B3546F0D4E8F1B" modified="2010-08-10" version="1">MIFDEEKGLPLSPEAGVLVLAAGKGTRMHSPLPKVLQKLLDKPMLWYLLTTLGTCFSSRPMVVTGHGSDLVQEACTEFEVDCIFQKQQLGTGHALQVAWDHIKKTGVDWLVVLNGDTPLISRQQIHSLLNSVRSNDADIGLMSLELDDPGGYGRVLRSAEGSVEAIVEAGDFDPRVHGPDVSEVNSGLYAFKTSSLKGILFELDADNIQGELYLTQLISLARQAGMKIEAVNAGRCPGLLGVNNPGELIQQEENVRSCIVNRFMGQGVFIRSPQTVRIGPEVCIEPGARITGPVEIYGKSRVSSLSSISANCYIEDSFIDGGQVFCFSHIVESVIDTDTKVGPYARLRPGTRMSKGSRAGNFVEIKNSTVGAGSKVNHLSYIGDTAMGQEVNVGAGTITCNYDGRAKHRTVIEDKVFIGSNTALVAPVVLQQKSMIAAGSTITRDVPVESLGIGRSRQKNLEGKSPLKKFKNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSG2</accession>
    <name>D6SSG2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870978.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0963"/>
    <dbReference type="EnsemblBacteria" id="EFI33628">
        <property type="protein sequence ID" value="EFI33628"/>
        <property type="gene ID" value="Dthio_PD0963"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="76"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="413" mass="47003" checksum="EF4CD1E7608DA757" modified="2010-08-10" version="1">MENQQNTPQDQEVKQKRTVLGRIFSPWTFLILILAVGVYFYLEHEPEQENDQPRERPEVAVELAPASEITMLETVRGVGTLRPVQRVDIKPETSGRIKAAHFQEGGFVGKDKLLFEIEEQKLLRRLSSQEAALEEAQARLENLRRNHQRFSILLSQEVVSQEEYDQVKTDLETTKAQVRRLEADVEHVREEIDDTVIRAPFDGLIAERLVDPGTFVSQGETLTVMYQVDPLKISFFLPEKYFAQAELGQKVRVAVPAYPGMSFEGEVDYISPSIDESTRKFRVRADIENPDNLLRPGFFAQATQILGKQEDSLVIPEKSLVAVREGYMVFTVDRENGRAKAQMVSTGMRRPGLVQITEGLSRNDLVVTAGHMQLEDDSRVEIVEEMEDDWAGQWDESLPDEGFDTAEQFRGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSH1</accession>
    <name>D6SSH1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diguanylate cyclase with PAS/PAC sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870986.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0972"/>
    <dbReference type="EnsemblBacteria" id="EFI33637">
        <property type="protein sequence ID" value="EFI33637"/>
        <property type="gene ID" value="Dthio_PD0972"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="247"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="322"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="503"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="574"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="621"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="698"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="780"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="915" mass="104152" checksum="260DC37A57F82C65" modified="2010-08-10" version="1">MLEKTFGERVRLFRALKNLTQGQLADMLDISRHHMGCLERGESGPSFGLIRKLCTLLQVHPASLFLSSDQEPEYPEESQVDTSPLQQIPFMSGHGTWNISIPNGPETWSRQLWQTLGYSTSREPSLGLFLKHVHQESRQAFEAFYRQLASGSIPPPESFWITRRDAVQRKIQARGDIIKGPGSSSPLACLSLLDITEWLEMQHHLMYNQNHLQNAVLQKTRALSRAVEETRQELELRKAAQEFAREQQEKMESILNNMDDGVWSASWPDMDILFISPSLSGIFGYSTAELQKNNNLWFQAIHSEDRHIVEKSLLDLPREKRKSLEYRIVRPDGEIRWINDRHWLILDPSTGTPVRVDGLTVDITQRLQIRRQLAESEEKFRSLTLNAPVGIAMHEIVLNPHGDPVDYIFLDVNPAFETQTGLKPSEVLGRRASQVLPGIENTSILSFFGQVVSSGDPMDFEFYSSPLQRFYMVHAYKISHRRFAAVFIDITSQKQMEQALGESERRYRGLVESQNDLIVRVDTDNRLTYVNDTYCRTFGRTREELMGKSFTPLVHQDDIQATLQAMEGLKVPPHRIQVQQRAMTVDGWRWIFWEDNAVLDEHGHIVEIQGVGRDITELKSRQVLLQSIFQASQDVSFVVTQNMPHSGDIILEFSPGAENLFGYSREEVLGKPVAMLHDPADIPRFPDIHRTLKENQPWRDKVNLVRRDGSTFPSLFTVYPFEYDGKDSTLGVSIDISELEQARKILEKTAITDHLTGLMNRSRFDQLMEEEWRRAKRGGHCLSILMLDIDNFKQFNDFYGHIQGDRCLQRIAGILSACLMRAGDVLARYGGEEFIALLPDTPLQSAVVVAEKMRMSVENLGMPNTGSQAGPFVSVSAGVASSCPFPGMSRQGLIHQADMMLYKAKSLGRNTVAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSI9</accession>
    <name>D6SSI9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871004.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0991"/>
    <dbReference type="EnsemblBacteria" id="EFI33655">
        <property type="protein sequence ID" value="EFI33655"/>
        <property type="gene ID" value="Dthio_PD0991"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1659069at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030410">
        <property type="term" value="F:nicotianamine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030418">
        <property type="term" value="P:nicotianamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004298">
        <property type="entry name" value="Nicotian_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03059">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="208" mass="23010" checksum="C9926FA95868728F" modified="2010-08-10" version="1">MSWIPMAVAAWEKMSSSSKILTWLYSRPYRQVIENEITLAKLGKDDVVLNIGCGAVPFTALYIAKLAGSRVYALDIDPCAAGYAEKCVKKAGLEDRITVMHADGAQDFRHNFTASIVALQAAPKNRILEVMQKKSRPGARFIFRLASSPYKDHYDCLQTKIRPEAETFQPMRTFDRSVLYQNKGPAVSVHPAFNPATADPSLLATKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSZ7</accession>
    <name>D6SSZ7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="10" type="ORF">Dthio_PD1152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1152"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="EFI33813">
        <property type="protein sequence ID" value="EFI33813"/>
        <property type="gene ID" value="Dthio_PD1152"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="16"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="471" mass="52613" checksum="CBEC990E807A903E" modified="2010-08-10" version="1">MAALPHGKKVMKKEYCGLFGIHDHPEAARMTYFGLYALQHRGQESAGIVTWDGSRIREQKGMGLVGDIFSEKHLGHQLKGTIASGHLRYSTTGASLLRNAQPFLVRFKDISIAISHNGNLVNTTEIRQELEQQGSIFQTTMDSEIIVHLLSRNMNGNSLEDALKKALQKVKGAYTLLIMANDKLIAVRDPNGFRPMSIGRLGDSYVFASETCAFDLLEAEYLRCVQPGEMVVVENGRLESTQFAEVSEPSPCVFELIYFARPDSIVFDDEVYHARKEMGRALAREAPVEADYVMPFPDSGVYAAVGYARESGIPFEMAMIRNHYVGRTFIQPSQDMRDFGVRVKLNPARSMIRDKKILIVEDSIVRGTTIRTRVKKLRELGAKEIHMRVSCPPIKHPCYYGIDFSSKGELIAANQSVEDIAEFIGLDSLHYLSVDGLLASLNSNRSFCLACFNGTYPVPPSPNCDKLCLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST24</accession>
    <name>D6ST24_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871189.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1179"/>
    <dbReference type="EnsemblBacteria" id="EFI33840">
        <property type="protein sequence ID" value="EFI33840"/>
        <property type="gene ID" value="Dthio_PD1179"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="70"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="158" mass="18003" checksum="4DE0809FF771BE47" modified="2010-08-10" version="1">MGYENVVVFPEGDEHWADQGYKLWTIEDITEPDEAEVAEAEEAAEPSDIKEGEFPGSIDEDFFVELMETDPGSIRLIDVRDEDEFSRGHLPQAERMNVDEIRANMDEFDDEKPIVLICATGARSGEAYFTFQDQRPELDVYYLDANVSYGEDGSFEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST27</accession>
    <name>D6ST27_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SirA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871192.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1182"/>
    <dbReference type="EnsemblBacteria" id="EFI33843">
        <property type="protein sequence ID" value="EFI33843"/>
        <property type="gene ID" value="Dthio_PD1182"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="81" mass="8743" checksum="4E9ED174F59993B1" modified="2010-08-10" version="1">MDTSTINADKVVDTSGLSCPMPLLKTKKAMKELSSGQVLQVIGTDPGSKNDIPEFGNKDGNEFLGMQDTDEGKTNYYIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST35</accession>
    <name>D6ST35_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bile acid:sodium symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871200.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1190"/>
    <dbReference type="EnsemblBacteria" id="EFI33851">
        <property type="protein sequence ID" value="EFI33851"/>
        <property type="gene ID" value="Dthio_PD1190"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1317830at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="323" mass="34885" checksum="1B700DA845937FD4" modified="2010-08-10" version="1">MANWLKKNWFMVGLVTAVFLAWLFPEPGARGGVLQSENTTRLGVVLIFFFQGLTLSMAAIRDGLMQWRLHIFVQAFIYVLIPLAALGMILVTYPVLSQDMRTGFFFLAVLPTTIATSVAYTFMTKGNVAGAVFNSSLANVAGILITPLWVSVWLQAGGVALPLGQLLLDISLLLLAPFVAGQLLRPFVYRVADALKKTFSTTSSLIIIFIVYAAFCNSWKDGIWEEEGTKAALTAGAGSVVFLALVLGLVVLGIRIVRFDHQNAMAALFCAPQKTMAAGVPMANLIFEGHSGLGVILLPLMFYHLLQLLVGGMLVTKINAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST41</accession>
    <name>D6ST41_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871206.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1196"/>
    <dbReference type="EnsemblBacteria" id="EFI33857">
        <property type="protein sequence ID" value="EFI33857"/>
        <property type="gene ID" value="Dthio_PD1196"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184499at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="698"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="815"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="924"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1046" mass="119959" checksum="DF15A420F35664E7" modified="2010-08-10" version="1">MQKEIQDITSRDTSTHSCPDQENVSPLFFDKSDYDLLRMVNDVYTRKTYPEQKRLLTPHLHPHGIKEMAAPRAQRIAYSVIQLLESLESGERQDRISALGSLRDEVLYTSHGHMRINTARVLVEIMKNLVRSHGDCRRQLELARDFAMVSLGKPRKVRSELKRYHLLEMPEEWNQVAFDEHVHDVNTTGRKSPTHLIMDAWIKGIRRLTVIYYNHVPREAAEELLQAASIMDIKVMVGIEFTVKLRDKPVRMVWVPRGFSDSGGFIDFLRSPRIRQFMDQGREISSLTRSYVLRLLHSFNRNHLPAINQEMGLNLAPLDENSFLKSVGQGQVSVHHLGKYIHELISAELAAKNCYSRPGQSPDPSGEADDMVQEPDIYDIIENYLRTSQNPDVPDIFETEDPPELLTLTPEELAEKLKSLHANSNITLNLCDLKVEDVIEILFDCKGMITHLEILNLKNQVLGREHDKERIINLQNAINAGNVIKLKKYLGQLVREAEERQSLDSSRRDKLVEILCDISTLQSFYQNRPLYGCIGSDSTGRSGRVYGMGLILSESLPRSARRQLAGGSRNDHQRLDVGIKSLTQDTYIPKTRYNFLSAGVSRVLKKIPALNRLEYQRVREWIVQDYYSLSPEKSNIFTLGGIHSPGEDGPGGRHNETKRTRGLASLKYLNTRIKIASKIGIGFIPAFLTFLLTHEWWILMYFGAVIWFGITGVRNVIQSVLGCGGINRPSLAKWSTFVSWDRFADSLMYTGFSVPLLDFILKTLILDQGFGATVATHPVIVYATISLVNGMYLSTHNYFRGLPRAAVIGNFFRSLLAIPLALVFNWLAGGILAFMGVAAVDRILQQWATIISKLASDTVAGIIEGFADRALYIRRRIMDYRRKLQHLFDTYAQLEMLFPMDDVLDLLESTRELMLTIEYEKRDMVNIIIVNALDLMYFWMYQPRAKGVLKLLLRQMTREERKVFLLSQHVLFRQKRISRLLVDGLVGKNFARALSFYLDHWREYLEEIEYQANKYPPVQEDMHKYSMLESLYHPAAGNINRPPDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST45</accession>
    <name>D6ST45_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33861">
        <property type="protein sequence ID" value="EFI33861"/>
        <property type="gene ID" value="Dthio_PD1200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="31" mass="3029" checksum="957A464F957D547F" modified="2010-08-10" version="1">MSVTVSVLLAVLVGGAVLGLLAWKGGESCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6STA0</accession>
    <name>D6STA0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD1255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1255"/>
    <dbReference type="EnsemblBacteria" id="EFI33916">
        <property type="protein sequence ID" value="EFI33916"/>
        <property type="gene ID" value="Dthio_PD1255"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="375" mass="42234" checksum="CDD762FF18838E63" modified="2010-08-10" version="1">MLLYIHVPFCRTKCAYCAFASQEYIQEPAAVYLRLVQQELEVRSRQIQHRKVTSIYMGGGTPTVLPVASLARIVDAVYKNFDPVPGCEFTLEANPENILEMDDLQVFSSMGINRISLGMQSLDDQLLGTLERGHDSRQAIKAARMIRQAGFALLSLDFIWGIPGQTLKGWLGELAHAVHLAPDHLSCYGLGLEPGTRLTARIRAGELEMPEERAQARMYMHGAEYLESCGFLQYEISNFARMGYSCKHNLGYWAGEPFLGAGPSAVSTIDGTRWQNPPAIRDYQTLGGKNFSDLEFEKLSYTRKVNELVMLSLRTSRGLNLHDYKHLTGQSFSRRYAGIIKALHQNNLIRMAHGYLRLTRNGMLVSDSILEKFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6STB8</accession>
    <name>D6STB8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871283.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1273"/>
    <dbReference type="EnsemblBacteria" id="EFI33934">
        <property type="protein sequence ID" value="EFI33934"/>
        <property type="gene ID" value="Dthio_PD1273"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCBE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1022457at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="437" mass="47451" checksum="786FF7EF9742E072" modified="2010-08-10" version="1">MKRLITLAIMVAFILGTVGMAKAIEFQAKGDWQIGINAVSNPTFDSDDDQDEFMATTRVRTTFEFIANENLKGVMRVHSGDRRWGDGGSGSQIGREGAVGNSSFEYDRAYLDFMIPNSPVNMKVGKQPIAFPNTLGSHIFDNSLWAVSASSSVIDMVDVTVGWARIDDTFADGDNKNDEYDLFYGIVPVNMDGFAVNPFVAYGMKGSDHAGATESSGVFWAGLNFTVDMFDPIVVMGDFNYGTHGSTETASGDVGDEARGWIADLAVQYKMDMVTPEVFILYESGESRSSGAIDNRSKIMPSIGGDLFGVSTFAMSGSPLRGIGRATLDGYAGISAWGPSGKMAVGGKLGDMSFLDDVTHDLQLTYYQGTNHKDNEGLFTTRDSAWEVTFDTSYQMYENLAAILELGYLHPSINNSSDRGIEDDAAFKAATGFRYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6STF7</accession>
    <name>D6STF7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TolB_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871322.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1312"/>
    <dbReference type="EnsemblBacteria" id="EFI33973">
        <property type="protein sequence ID" value="EFI33973"/>
        <property type="gene ID" value="Dthio_PD1312"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="483611at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007195">
        <property type="entry name" value="TolB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04052">
        <property type="entry name" value="TolB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088296" description="TolB_N domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="TolB_N" evidence="6">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="532" mass="59995" checksum="B63ABC896BA15427" modified="2010-08-10" version="1">MIKKILVLLSFLLVFSAQAWSGQEPKKYAVMPIEIHGPQEYAYLKQGIQSMLSSRLTRTGETSPIPPGEVNQQVEAPPASEEEARELLTALGVDFLVYGSATIVNDSCNLEIYVLDADMERHRLDRESSLGQLIPDLEDLAQDLTAMVVDDAEARAEPDDLEPVAPVAEAPPQDEAYVSPHFEFRDDPQAAGRWRSQTLPFSSVGIAVGDTQGDGEQNIFILADRRVHAYRMHEERLDHLSTYEAPGTYQNLNINVLDTNRDGKKEIIVSAVQDKRARSYILGFEDNEFKELHRRIGFFMNVTKTPPNYEQTLVGQRIASGSRLFRPGAVQEVIFTDGEPELGPGISLPDRANIFNFAFLPRNDDHLVVVAENDRLEVYSSDDRRRYTTSEEYAGSGLGLEIDDTMPGMGQTSPSEREVSYYYIPTRLVTTRLEGQDEYQLLAHKHFSGRLASVFQRYRNFPEGEIHALFWDDVGLNIHWNTRRIQASIEDFGLYDMDGDGNKELVVCVNTHPGITGMQQQRTIVLAYKMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6STI9</accession>
    <name>D6STI9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="4" type="ORF">Dthio_PD1344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871354.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1344"/>
    <dbReference type="EnsemblBacteria" id="EFI34005">
        <property type="protein sequence ID" value="EFI34005"/>
        <property type="gene ID" value="Dthio_PD1344"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="9100" checksum="8326EC749DE8AB7C" modified="2010-08-10" version="1">MAVRLRLTRMGSKKKPFYRLVALDSETRRDGRALEYLGYYNPLQDPPEIKINMDKVKAWMDKGAKPTDTVRSLIKKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU64</accession>
    <name>D6SU64_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871540.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0151"/>
    <dbReference type="EnsemblBacteria" id="EFI32844">
        <property type="protein sequence ID" value="EFI32844"/>
        <property type="gene ID" value="Dthio_PD0151"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50332WW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630139at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="231" mass="26325" checksum="45E883B5622DFA78" modified="2010-08-10" version="1">MSYSVCLEDNLLGLLYAFKHGRGHDPLLAERLLHLYKPPHITNVSQLERLGIEEAPLKAQLAGSGLITQSIEELARKTLYKIILSSQKGDFPYVNVQGDPLQNHYTITCKPGESRVKALAHLRALLEGAKNVVVCDRHLKTNWEAARKLFGLFPRKSVAIDFAHPLKQSQNTALKKICSTWKLKQDRTQAYRDLHDRYLLIDRAMEVVITSGVDYLFDDSKECTLIFRIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU79</accession>
    <name>D6SU79_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871553.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0167"/>
    <dbReference type="EnsemblBacteria" id="EFI32859">
        <property type="protein sequence ID" value="EFI32859"/>
        <property type="gene ID" value="Dthio_PD0167"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2217681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="10564" checksum="68BB874D4E8AEB53" modified="2010-08-10" version="1">MQIKATYNRGCLEFSVPIRLSRDEFTVLVDLPDDVVLSTEAGSKQEKSAPSSEEAGSELLAKFRRILGSMHRQRPSASVGEDKDAYAEALGEKYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU91</accession>
    <name>D6SU91_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871565.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32871">
        <property type="protein sequence ID" value="EFI32871"/>
        <property type="gene ID" value="Dthio_PD0181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8359" checksum="1517F0EB89447966" modified="2010-08-10" version="1">MSQTMTFGGLLEEVEKLPLEEQDMFKEILSKRLMERRRNQLFDEIQKARAEYSAGECYPVSVNDLMDEIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU94</accession>
    <name>D6SU94_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871568.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32874">
        <property type="protein sequence ID" value="EFI32874"/>
        <property type="gene ID" value="Dthio_PD0186"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935911at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="62"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="118" mass="13691" checksum="2EFDA0F127993730" modified="2010-08-10" version="1">MSEPMKKPHTDEEIITLNLRVRRSIAGKIKQYAQFLEDEDKPAYSVADVFPEYMDKNPQIALRAYRTRESLTQKELSLKTGIPQHQTSEMENGKRGIGKERARKLAQALSVSDYRYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUB0</accession>
    <name>D6SUB0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">Dthio_PD0204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871583.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0204"/>
    <dbReference type="EnsemblBacteria" id="EFI32890">
        <property type="protein sequence ID" value="EFI32890"/>
        <property type="gene ID" value="Dthio_PD0204"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="216" mass="24111" checksum="B738A9B26C466704" modified="2010-08-10" version="1">MPNLNNPAGRITGPRLIAGLGNPGNRYRNTRHNMGFLVLDHAMDSARWEPGEHVRCLDEKNEFTLWEWTMPEDPAARYLLKPMTYMNRSGKAVARVADRLNILAESILVVHDEVDLPLGRVKLKFGGGLAGHNGLRSIADHLGSRDFARLRIGVGRPEDQISLSEYVLQKFTPEEQNDLKDSLDRSVAALRLLFTHGKQPALQHINSPGGDQAHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUE9</accession>
    <name>D6SUE9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0243"/>
    <dbReference type="EnsemblBacteria" id="EFI32929">
        <property type="protein sequence ID" value="EFI32929"/>
        <property type="gene ID" value="Dthio_PD0243"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="182" mass="20739" checksum="2FC222E9AD6568A7" modified="2010-08-10" version="1">MQPSAFTLFSGGARGAEAYFGELAEKYGLDEVNYSFEGHPIERTRGVRYLTNEELAKKDVSITYVSNLMHRNYSRAPIFRKVLQTICWQVSSGMEVFVVGQIQDDNTVKGGTGWGAEYAKICNKPLFVFDQVKNAWFTWDEGEWRQIQAPVISRQHFTGTGTRFLEDNGRQALDDLFKRSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUG3</accession>
    <name>D6SUG3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="5">SDH</shortName>
            <ecNumber evidence="1 5">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aroE</name>
        <name evidence="8" type="ORF">Dthio_PD0257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1 5"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871636.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0257"/>
    <dbReference type="EnsemblBacteria" id="EFI32943">
        <property type="protein sequence ID" value="EFI32943"/>
        <property type="gene ID" value="Dthio_PD0257"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1054867at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="6">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="7">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="268" mass="29969" checksum="40E58837EB5A5FFF" modified="2010-08-10" version="1">MYQAYGVLGRTLGHSLSPYLHNCAFQAAGMKRVYLKWEIEPENLGDFIRAVRILPLSGASVTIPYKEDVMEYLDYISPEASDMGAVNTLYWHRKSLCGTNTDCRGFMAPIEDLQLDSALILGAGGASRAVLYGLKRMGISNIYLTNRSKKKALAMAGEFNVKSIPWDERYRLKADLLVNTTPLGTAGDLQDLSPWESSIFPFKIVYDLVYNPLQTRLLQQARAHGAHTVSGLSMFVHQALKQFKIWTGQGFDPGWAEDLLQRKITGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUI7</accession>
    <name>D6SUI7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0281"/>
    <dbReference type="EnsemblBacteria" id="EFI32967">
        <property type="protein sequence ID" value="EFI32967"/>
        <property type="gene ID" value="Dthio_PD0281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="242"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="578" mass="66006" checksum="2C70D75109E240DE" modified="2010-08-10" version="1">MNSKSPPLYADRRINTRAGNTCKPDQNLLQVPREDSISGPSRSKSREWGGRLPVALVFPEERSLALSTLGWQAVYMQLEEEGTFHVQRFFWDRRQGRAVNQDSDKTLSDFPLICFSLNFEGDYLNLVQSLQAEGIEVYSGNREKWPLVMAGGPVTFINPFPVMPSLDFIYVGESEDTFICIAGALKNCFLQGKDRHKTLETIAGLPGIYVSGRTSRAHRQVAESDSRRLETPAHSAFVSGQSVFRDSFLVEINRGCPHGCRFCAAGFVYRPPRTADINKLKELISGIRPRKVGLVGTALTDWPDLQEFLQWLKAQKIKFSLSSMRSDGLTSSFLEFLRRSGTRSITLAVEGISRDLRTAVNKRFDHKKFFQAVEEISRLQFNTLKLYFILGLPGESGKDFQELENFLEEMQQARFKGMGNRKKGIGLIQISASMFVPKPWTPLQWAAMISRQEFESGCRRFKKLCSRHKAVKFTSENPFQARIQGLLARGDEKVHELLLLAAEHQGSWKKALANWSRDMERYTDRQIPLEENLPWDRLDIGVKKEYLKREWRKYWQGRLTSPCPDTECSNCLRCGMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUP7</accession>
    <name>D6SUP7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmG</name>
        <name evidence="6" type="ORF">Dthio_PD0341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871720.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0341"/>
    <dbReference type="EnsemblBacteria" id="EFI33027">
        <property type="protein sequence ID" value="EFI33027"/>
        <property type="gene ID" value="Dthio_PD0341"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="49" mass="5645" checksum="BB7B9FFDBEF1D7F7" modified="2010-08-10" version="1">MRVNILLSCSGCKRRNYATCKNKKNTTSKLELKKFCAFCGKHLPHKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUQ5</accession>
    <name>D6SUQ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NLP/P60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0349"/>
    <dbReference type="MEROPS" id="C40.006"/>
    <dbReference type="EnsemblBacteria" id="EFI33035">
        <property type="protein sequence ID" value="EFI33035"/>
        <property type="gene ID" value="Dthio_PD0349"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="2">
        <location>
            <begin position="50"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="141"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="265" mass="29555" checksum="D3961904CF50DE1F" modified="2010-08-10" version="1">MPLDTDCKIGKKSSMLKQLPGILNLLLIFVLLCACAPREPAPDHPPPKKKLDSMQYSIQAGAFSVLDNAVSLMENLKQQGLEAYYFKDEDGLYKVRVGNFSDFQQAGQKAQDLRRQGVLQEYFVVDPQSYPSARAVEKGTDYVRSRLVETAREFIGVPYKWGGSSPDSGFDCSGLTMVVYRHNGLDLPRVAARQYQAGTPVPRDSLQKGDLIFFDTRDKGKVTHVGIYIGNGRFIHAPSSGRDVTRASLSSPYFRNRYLGARSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJS1</accession>
    <name>D6SJS1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869249.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3577"/>
    <dbReference type="EnsemblBacteria" id="EFI36124">
        <property type="protein sequence ID" value="EFI36124"/>
        <property type="gene ID" value="Dthio_PD3577"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="149" mass="16884" checksum="601791D7AA3981F3" modified="2010-08-10" version="1">MQQKTILLVEDNPDDVLLTQRALKKNNISNELVVARDGVEALDYLFGTGAWQGRDLSIQPVVILLDLMLPRLDGMEVLRRIRASELTSLLPVVILTTSREDRDRLQTYSLGANSFVRKPVDFEQFIEAVRQLGLYWLVLNEPPPAPKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJT0</accession>
    <name>D6SJT0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869258.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3586"/>
    <dbReference type="EnsemblBacteria" id="EFI36133">
        <property type="protein sequence ID" value="EFI36133"/>
        <property type="gene ID" value="Dthio_PD3586"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZKXF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1346329at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="204" mass="22162" checksum="8D9EC88F9C686F43" modified="2010-08-10" version="1">MSHPARRSIRLPAVVILVVLTAVIAALVTLLVARLWIFQPEVSPVVLDSQEQAELDQKVKALTDKSQLYDERPDDRVIYLTERELNAIVARDPDLANRASFSLSEETISAILLVDMPEDVPGIGGQTVEISAGLRVGHADGRPTVILEGISVMGVPIPSAWLGGWKGKDLVQADGPGGGVWDIFSEGVKDLRVEDGRLRIELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK24</accession>
    <name>D6SK24_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869349.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3684"/>
    <dbReference type="EnsemblBacteria" id="EFI36227">
        <property type="protein sequence ID" value="EFI36227"/>
        <property type="gene ID" value="Dthio_PD3684"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677146at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="213" mass="25105" checksum="2EFE760018C7D249" modified="2010-08-10" version="1">MEEIDFKQLYELQDQVLEAVFLVDTTFYLTGGTCLHRFYFSERYSVDLDFFTNDTALFREDVRDLLNRLDQKSIQYEPVTDFRDFVRIMVEKKLRVDLICDRVYRSGKNVRTKKGLVLDNLLNLCANKVCAILGRDEPKDVFDLYTVYRHDPQDWAVVMEEAGKKCVLDRETLAFRLDSFPVELVESLHVLDKNIINVFKQDYPVMLREMSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK39</accession>
    <name>D6SK39_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869364.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3699"/>
    <dbReference type="EnsemblBacteria" id="EFI36242">
        <property type="protein sequence ID" value="EFI36242"/>
        <property type="gene ID" value="Dthio_PD3699"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1857712at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="125" mass="13896" checksum="2E0DE6A374792E44" modified="2010-08-10" version="1">MKQSGFTIIEALMAVAVLGIIVAGILPAYSHYSQLNTRSELKSSAAAMAQEQMEKMRRLDFSMWEASGHTETKSMGGREFTMEVTHSQYKPDEGTTISGARKIHTKISSGDRLIYEVTTIYTQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK73</accession>
    <name>D6SK73_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnp</name>
        <name evidence="10" type="ORF">Dthio_PD3739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869395.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3739"/>
    <dbReference type="EnsemblBacteria" id="EFI36276">
        <property type="protein sequence ID" value="EFI36276"/>
        <property type="gene ID" value="Dthio_PD3739"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="628"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="704"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI36276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="739" mass="80544" checksum="CC695D641E4ACF38" modified="2010-08-10" version="1">MLKEFNSTKITSVAGDCKINFETGKMANQAHGSVLVQSGDTVVLVTAVTQPMENNPGFFPLTVNYQEMSYAAGKIPGSYFRREIGRPSERETLVSRLIDRSIRPLFPETFNDEVQVMATVLSADPVNDPDILAISGASAALHMSKIPFMGPLAGARVGYIDDEFILNPSLKLLDQSDLSLMVASTRNGVVMVEGVADFVPEDIVARAIDWASQQVIPILDSQEELRSQCGREKMEIPAEPERDLELEEMVKEMAAGDLARALETQGKMHRKNAKSEVKERVQASLQEKLGPESERLDKFGGIFKDLEKSIMREKISSEKIRIDGRDLKTVRPLSMEVGLLPRTHGSALFTRGETTALTIATLGSSTDIQHIETLSGDSSKSFMLHYNFPPYCVGEVKFLRGPSRREIGHGVLAERAIQPVLPSSEDFPFTIRLVSEIMDSNGSSSMATVCGGTLALMDAGIPVKEPVAGIAMGLIRENDEYLVLTDILGDEDHLGDMDFKVAGSYDGITAVQMDIKISGISGEIMHQALDQALEARRHILDQMKQVIDEPRKELSPFAPKMEVIHVDTNKIKDVIGPSGKHIKAITAETGSSIDIEDSGKISIFAPSEEILQKTKEMILFYNQKPELGKDYEGVVTRLLDFGAVVEILPGLDGLVHISQLDTARVEKVSDVVNIGDKIKVKVIEIDDRGKVRLSRMAVLMEEQGKTFDMSSASRPGPKKGGGGGRSGGPPRGGGGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKC8</accession>
    <name>D6SKC8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869450.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36331">
        <property type="protein sequence ID" value="EFI36331"/>
        <property type="gene ID" value="Dthio_PD3797"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XA7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1941315at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="102" mass="12181" checksum="84FA5E967773CB09" modified="2010-08-10" version="1">MPDNEQLRRLAKKYVWWKSPEQALQNKRHFLAALMTFGTLEDTYWLEQNITRDELTDVLKNPPIGIFTARAWHFWHYRLGLAGNENEIPEQPTRTWQKSVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKD0</accession>
    <name>D6SKD0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869452.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3799"/>
    <dbReference type="EnsemblBacteria" id="EFI36333">
        <property type="protein sequence ID" value="EFI36333"/>
        <property type="gene ID" value="Dthio_PD3799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1842663at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="138" mass="15591" checksum="4378C95A85BBB4A7" modified="2010-08-10" version="1">MSDIPLDTNVIVRYLTESSQDVDAKFEGAIGFFEKLEAGSLSVFLPDLVLFQAYFVLTSFYKAPRAEVADKFRRIVEFSGIRMTDKNVIIACLSRLQSQNLDVVDCYLLGWAESRGVNCVYSFDSDLEKNGLELLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKL0</accession>
    <name>D6SKL0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868355.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2630"/>
    <dbReference type="EnsemblBacteria" id="EFI35221">
        <property type="protein sequence ID" value="EFI35221"/>
        <property type="gene ID" value="Dthio_PD2630"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="508"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="577"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="643"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="292"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="853" mass="96648" checksum="4F5AB1C6BA25C4B8" modified="2010-08-10" version="1">MQKNGNKDDLRRKSSWFKSSMGVQSKFLLGTGLILLAVCLVSAFVIYFYEKRQMEQDALAKSELVMGAVDASRDYVREVLRPAMYEKYGQDHFMLEAMSTSYVGRSVMDRFTPTLEEFDYRRVSINARNTDYEASELEREKIEHFAEQGKTGEWQGVVSVNGKDQFKRYRPVVFESECMRCHGSPDDAPEVLVEMYGSERGFGRSEGELAGLSVVSIPVEAAMAQVREKAFSVFLVVFLGVSIVFIALSFFFNRMVVTNLRGLLEIFRDEADSHPANLVHIPSRGMDAGDELNELTDAASSMAEHLRRTREQLRQYAQNLEVKVQERTRALRDSEERLQVQVRARNQELQTLNVLAELTTQAVGLSEILPQVLHWTLKTFPARGAGIYLYDENQRMLVLQYHENSPGLSTKVPLQGQDLPASMYQPRNLEESIVQAACGQASYFDCRQNSGCLNIPLCCRGRVLGVMTFSGVNENELTSEMHSLLASIGRQIGIAVESLQNMEKLLQSKELLQSVFDGITDQVILMDRDFRIKMVNRAYARMYNVDMDEVIGRRCYEIHGSGERPCHDCGLNEVLKTRTPVVLETRCPAPEGIFQVHCYPVLDESGDVERVIRYVKEITDQKQMEQKIQQTEKLVAMGQLAAGVAHEINNPLGVILCYVELLKRQFSEVPQGQEDLVTIEKQARNCKRIVSDLLEFARSGETSKHTASLNQTLEEVLGMVGEQFKKQGVQIETDLDPDLPQMEMDTNKIKQVFMNLLMNARQAMDGRDGKMHISTRYMAQDSLARVIFWDNGEGIPEYMQDKIFDPFFSTKRTGEGTGLGLSVSYGIIREHGGEIIVESRPGEWTRFVIELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKL2</accession>
    <name>D6SKL2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein family UPF0324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868357.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2632"/>
    <dbReference type="EnsemblBacteria" id="EFI35223">
        <property type="protein sequence ID" value="EFI35223"/>
        <property type="gene ID" value="Dthio_PD2632"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856009at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="600" mass="65057" checksum="ED5116FBA18EBC26" modified="2010-08-10" version="1">MADNEKKEAQEAIQEEMAATSSSGKGRDWAQLYKKEDWWANWLGLALLLFALVVFWGATPADAPEKLEEFEAKVEYEEERAPFATIEQIEAQDELDDIRAQDYGLGPALASLIQRPQGWDDNPIEAFYMSESRAAEMREEAKPAYEEAQQKTEEAYDEAREAQEAAAEADFEDEALNEEAVNAIDAWLDARDAESSARSDANVEGYNIIPSMILLMILTGLMFSIGISFMGGNVGSFLMGYPIVFIISIIGFFIGNHAIASEYGLSYVLWCIIIGLLISNTMSTPGWVKPAVQTEYYIKTGLVLLGGSILFGLILMIGAPGIVVAWGVTPTVLIIGYWVGNRVIKLPSKPLNVCVAAAASVCGVSAAIAAAAASKAKGEELTIAVGLSLVFTALGMFLMPALVVAVGMNPILGGAWVGGTVDSTGAVVAAGELLGPGAMYTAATLKMIQNVMIGILAFGIAAYWATKVEREGSDVELTLGGALREIWTRFPKFVIGFVAASIFFTIVYESMGHQMGETVVQDGVLGGWANPLRAWFFAMAFTSIGLATNFRELAKYFAGGKILYHYIFTQGFNVILTLFLAWLMFMVFFPGVTEHLMEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKS2</accession>
    <name>D6SKS2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eight transmembrane protein EpsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868415.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2697"/>
    <dbReference type="EnsemblBacteria" id="EFI35283">
        <property type="protein sequence ID" value="EFI35283"/>
        <property type="gene ID" value="Dthio_PD2697"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1832262at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013426">
        <property type="entry name" value="EpsH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026491">
        <property type="entry name" value="ExosortD_VPLPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014263">
        <property type="entry name" value="Methanolan_biosynth_EpsI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11984">
        <property type="entry name" value="DUF3485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02602">
        <property type="entry name" value="8TM_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02914">
        <property type="entry name" value="EpsI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04152">
        <property type="entry name" value="exosort_VPLPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF3485" evidence="9">
        <location>
            <begin position="308"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="514" mass="58127" checksum="EC6498BB2606FE5A" modified="2010-08-10" version="1">MISSEYINKHWILAGAVLSVWVVLYLPYFGNMAGQWGHEDYSHAYLVPPVFLYLLWLSKDRFVWSTRDAGLWGFLIIICSMLVMSMGRLGSLETLIYFSMWMSLLGIFLFIFGTAVLRHITFPFAVLLFAIPLPAFLNNMVSFKLKLWSSALAEQILKLLSVPVFREGNIIDLGVTQLQVVDACSGLRYLFPTMLMAMLIGRFFLRSSTSRIILFALSPLLSLLSNSMRVAVTGVLARYIDPRLAEGFFHDFSGWLVYMFTLVFLGGVTLFLRKLETSRTMVQDDSAGRDTAVYSGYGIKRPMIKTAAILLVFISSLLLQSHMLHAQISPERKDFDCFPDRIAGWEGERLYLSQGILDSLWADDYVSGSFFHPETGNSLHLLVSYYEAQTTRKTAHAPTSCLLGSGWLMQSRELAPPSPVNGRDFPVQSMVMEQGGRRILANFWFDQRGRHITSEYWNKAYLFLDAVLMRRTDGALVRVEMFMLPGQSREEAQVVLDGFVAELKELLGAYVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL07</accession>
    <name>D6SL07_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase CocE/NonD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868500.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2783"/>
    <dbReference type="EnsemblBacteria" id="EFI35368">
        <property type="protein sequence ID" value="EFI35368"/>
        <property type="gene ID" value="Dthio_PD2783"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="327988at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="291"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="673" mass="76683" checksum="3BA7995BC843720C" modified="2010-08-10" version="1">MKTITSFPEKVRVLENEYIFLSDGTRLAAKIWIPLCADKEPVPAILEYIPYRKRDFEAVSDSITQGYLAGYGYACLRVDLRGAGESQGVLRDEYLQQELDDGVEVLAWIAAQPWCNGSIGMMGISWGGFNSLQIAALQPPQLKAIITVCSTDDRYADDVHYMGGCLLGDNLSWASTMFAYNSCPPDPDLVGDKWKEMWLERLDGSGLWLKNWLSHQRRDDFWKHGSVCEDFSRIKCPVMAVSGWADGYTNAVFRLLSGLSVPRKGLIGPWSHKYPHFGVPGPAIGFLQEALRWWDTWLKGKETGLMQEPMLRVWMQDSVPPSPLYKKRPGRWVAEPEWPSENINILTYHLHPGHLLLEEKPETKVYMTIQSPLSVGLFAGKWCSYAAPPDLPHDQREDDGGALIFETAPLETPLEILGAPVLELELSASEAVAMIAVRLSDVAPDDKATRVTYGLLNLCHRESHETPGLLEPGHSYRVRVQLNNIAQRFPAGNRLRVSISTSYWPLAWPSPRPVRLTIFAGLSRLELPVREAIHEDDKLRPFLEPEGAPAIRTSQLEPRRHRWRVIRDLAHDESTLEVVIDEGAVRFEDMDWTVTNRANEWYTFQDDDFVSVRGETLWFRRFQRGEWSVETVTRTVLTCSETHFRVHAEMDAYHGDERVFSRNWLCEIPRDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL12</accession>
    <name>D6SL12_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HicB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868505.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2789"/>
    <dbReference type="EnsemblBacteria" id="EFI35373">
        <property type="protein sequence ID" value="EFI35373"/>
        <property type="gene ID" value="Dthio_PD2789"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8168" checksum="7FFBF5F233ED2634" modified="2010-08-10" version="1">MDYKYEMIIYWSQEDEAFLVEVPELPGCMADGQSYEEAVANAQVVIEEWIETAREIGRHIPEPRGRLMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL26</accession>
    <name>D6SL26_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 5">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868519.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2803"/>
    <dbReference type="EnsemblBacteria" id="EFI35387">
        <property type="protein sequence ID" value="EFI35387"/>
        <property type="gene ID" value="Dthio_PD2803"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1402673at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="289" mass="32954" checksum="4D41F22DB5E6B70A" modified="2010-08-10" version="1">MEAKKVVIPVAGWGTRSLPATKNIPKEMLPIYKKPAVQHVVEEAIEADLTNVVFVTNQQKRILEDHFDYNLALEAVLRRTNKEYLLREVRQVAEMANIISVRQKEQLGLGHAVLCAREVVSKEPFAVMVGDDLMFSRRPAIKQLLEAAKTEHMSVVGVVEVSRESVSNYGIIQGEEISPGLYRIRNVYEKPRVEDAPSRLAIVGRYVLTPEIFEHLETLEPGHNLEYQLSDALQSMARNKRLLAVKLEGQRYDIGNWVDYLSANIHFALQDDELKSDLLKNLEEFLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL53</accession>
    <name>D6SL53_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868546.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2832"/>
    <dbReference type="EnsemblBacteria" id="EFI35414">
        <property type="protein sequence ID" value="EFI35414"/>
        <property type="gene ID" value="Dthio_PD2832"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="798280at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10535" checksum="B712EDE9AABC7434" modified="2010-08-10" version="1">MRLHEDKDLFVDVVRASAWKYAMRAVYIEKDYWATYALKNVFTSPVKESVVFKGGTSLSKVYGIIDRFSEDVDLALVTIQGADTGHGDSPALIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL66</accession>
    <name>D6SL66_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868559.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2847"/>
    <dbReference type="EnsemblBacteria" id="EFI35427">
        <property type="protein sequence ID" value="EFI35427"/>
        <property type="gene ID" value="Dthio_PD2847"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1698942at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010412">
        <property type="entry name" value="DUF1007"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06226">
        <property type="entry name" value="DUF1007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088096" evidence="1">
        <location>
            <begin position="34"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="24348" checksum="6F1FF7D54719A50E" modified="2010-08-10" version="1">MLSIINCYIRCCLIVSGLLFLGLQVSPASQALAHPHVFLETEIEIEFNEQGLKGVWQEWTFDEYQSSWIINQYNIDQEGEISSQELDRLYRETFENLKHYDFFTLLMLGDEKIPATKIEDFSVKVQDGLAIYSFFVPFDIEINQKKQELFILVYDESYFCQVFFPPDDIGFKGDLSSWEIDYSTQKKSSLTFYFGMITPEAIKLSISPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL82</accession>
    <name>D6SL82_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868575.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2863"/>
    <dbReference type="EnsemblBacteria" id="EFI35443">
        <property type="protein sequence ID" value="EFI35443"/>
        <property type="gene ID" value="Dthio_PD2863"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017174">
        <property type="term" value="F:glycine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014369">
        <property type="entry name" value="Gly/Sar_N_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16458">
        <property type="entry name" value="PTHR16458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000385">
        <property type="entry name" value="Gly_N-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51600">
        <property type="entry name" value="SAM_GNMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="6">
        <location>
            <begin position="63"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000385-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="268" mass="31368" checksum="7F401940C220C41A" modified="2010-08-10" version="1">MYADKEQKEILQSKGCLLTDQYLHDYEDCFVNKWDELIDWEKRAKSEGSFFYDIFRQRNVQSIMDVAAGTGFHSVRFLEQGYRVVSVDGSANMLVQAFENARDKGYILSTVHTDWRRLSFDVQGEYDALICLGNSFTHLFDEHDRRRVLSEFYSKLKPDGVLIVDQRNYDRILDEGYSSKHKYYYCGENVSAEPVQVKDDLVQFEYTFPDASVFHLNMFPLRKAYMQKLLYETGFGSVTTYGDFQETFRGEEPDFYIHVADKGIPDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL87</accession>
    <name>D6SL87_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868580.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2868"/>
    <dbReference type="EnsemblBacteria" id="EFI35448">
        <property type="protein sequence ID" value="EFI35448"/>
        <property type="gene ID" value="Dthio_PD2868"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="252" mass="28288" checksum="22288695FD32F42C" modified="2010-08-10" version="1">MILNVQDLCIGYDQGLVLKNLDFRVAHGEILGILGPNGAGKTTLLRCINRILKPSQGRVLVKDRDVLRMRSEEIARNLSYVAQKTEMGRMTAFDAVLLGRRPYLGWKVTHNDLRIVDAAIKRLGLEELALRHLDQMSGGELQKVCIARALVQEPTVMLLDEPTSSLDLKNQLEILRTIDFVVQEHELAAVMTMHDLNLALRFAHKFLFLKDGGIYHHGGIEELTPEMVKAVYGVEVDILNHQGNLVIVPKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLD5</accession>
    <name>D6SLD5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nitrogenase protein alpha chain</fullName>
            <ecNumber evidence="10">1.18.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD2919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate</text>
            <dbReference type="Rhea" id="RHEA:21448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17997"/>
            <dbReference type="ChEBI" id="CHEBI:18276"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.18.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[7Fe-Mo-9S-C-homocitryl] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30409"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[8Fe-7S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21143"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the NifD/NifK/NifE/NifN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.6.1" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868628.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2919"/>
    <dbReference type="EnsemblBacteria" id="EFI35496">
        <property type="protein sequence ID" value="EFI35496"/>
        <property type="gene ID" value="Dthio_PD2919"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="363662at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016612">
        <property type="term" value="C:molybdenum-iron nitrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018697">
        <property type="term" value="F:carbonyl sulfide nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010143">
        <property type="entry name" value="Nase_comp1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000318">
        <property type="entry name" value="Nase_comp1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005972">
        <property type="entry name" value="Nase_Mo-Fe_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43457">
        <property type="entry name" value="PTHR43457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01862">
        <property type="entry name" value="N2-ase-Ialpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01282">
        <property type="entry name" value="nifD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00699">
        <property type="entry name" value="NITROGENASE_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00090">
        <property type="entry name" value="NITROGENASE_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8 9" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="11">
        <location>
            <begin position="64"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="541" mass="60464" checksum="9095553E256DBE8D" modified="2010-08-10" version="1">MSDLKSCPSVDLEEFVDNILKKYPAKVAKKRKDHILVRKEEDPARESIQANNRTVPGIITQRGCCYAGCKGVVLGPVGDMVHITHGPIGCGFYAWLTRRNLFKPGEDGKNYSTYCFSTDMQEQDIIFGGEKKLKQAIKEAWETFKPNAISVHATCPVGLIGDDVQAVAREAEAELGVKVLAFNCEGYKGVSQSAGHHIANNKLFNETVGTKDEAIPGYSVNILGEYNIGGDAWEIERILEKCGIKIAATFSGDGKYDSMTSSHMASLNLIMCYRSINYLAEMMETKYGIPWAKVNFIGVKAMSKSLRKIARFFEDPELTRRIEEVIKEEEESVEQKLAPYRERLQGKTAMLFVGGSRAHHYQDLLRDLGMEPVAAGYEFAHRDDYEGSHIAGKIKVDADSRNIEELKVEPDPEKYSPRVSPEKKKELEQESVLGHYHGMIPDMPPGTLVVDDISHLELEELIKTLKPDIILSGIKDKYVIEKFNVPSKQIHNYDYSGPFAGYKGAVNFARDIDMMINNPAWKLAVPPFEKKPLLSADLGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLH0</accession>
    <name>D6SLH0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2955"/>
    <dbReference type="EnsemblBacteria" id="EFI35531">
        <property type="protein sequence ID" value="EFI35531"/>
        <property type="gene ID" value="Dthio_PD2955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="963" mass="105336" checksum="35092435FE4594FD" modified="2010-08-10" version="1">MKIKHRIYQIVYIFSCMMILILSGSFFTRSIASNEHSEFKIIDTNMSLTQSVNYEKDILILSGNVNLNGHTFTSSGSIYHVGGTINVNEGKLIVAHDYRLQSMEKDDEGKKKDSSGYLVMTGENDSVLVQGDFVTQSSHSHSNRLTSGILEVRGNFQQKAGSNHNFNASGSHKVILSGKEKQDVSFESPGNSGFALLEISNDHVHFDSVLRGWTLHDDLKIRNVGHGFTGTMDMAGNKMTVKGGIPEHHGTFKLAGGALDIHGDFIQSGGTVDIDGGRLTVTGDYRLQSMEKDDEGNKKDSNGYLVMTGENDSVLVQGDFITQSSRSHSNRLTSGTLEVQGNFMQKAGNNHNFNASGSHNVLLSGKKKQEVSFESPNNSGFGINTISNEEVYFLTVVRGWKLKEDAVIREMHGFTGTMDLGGRTLTVKNPVTMQGPGTCSLSRGKLVIGGDLVQPDGTLTIGGGTLIVQGDYIMQGMPQEEGGEPEDSRGYLNMTHDRDKVLVKGDFITQTSRSHSNRLTRGVLEVRGDFHQKAGNNHNFNASESHKVLFSGENEQRVFFEAPGNSGFAGCSISNKDVYFDSVLRGWRLTDDAVIKGLYGFNGTMDLDGHSLTVDNSISFEGPGTLDISSGNFTVQGNLVQPDGTLTIGGGTLVVHGDYIMQGMPQEEGGEPEDSRGYLNMTHDRDKVLVKGDFITQTSRSHSNRLTRGVLEVRGDFQQKAGNNHNFNATESHKVVFSGDSMQRVSFERPQNSGFQILILVNDHNNRVVLPESFRVHTKFGVSLSPVQMDLVSGASSNLEVAVDARDHKLSWEPVDIQVASLSELGEVTGEEPGLTQIKLISLNNPDVFLYSWVNVLPEKSSVSDYTAEHTVLHDQVTVRALGAWGHLPDRFSRLALDLRRHGVDLLGADMAEISELLAKAESGTNRSISEYAQDIRALKEHMERFAFNNEGELVPVDTGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLH9</accession>
    <name>D6SLH9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2964"/>
    <dbReference type="EnsemblBacteria" id="EFI35540">
        <property type="protein sequence ID" value="EFI35540"/>
        <property type="gene ID" value="Dthio_PD2964"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="26489" checksum="E6475B4B3C0C8A09" modified="2010-08-10" version="1">MIHLDNLYKRREQAGSVFELFVPELKIAPGRMVALVGDSGCGKSTLLDMLALVMQPTRVGRFILNPGREQDAAIDVQSLWENGLESHLARLRRNFMGYILQTGGLLSFLSVMDNVCLPARIKGSKDYLTQVTALAARLGIEHCLKRKPDYLSIGQRQRAAILRAMAHGPALVLADEPTAAVDKARARIIMQDLQSVTRESGTAVVVVTHDTELVTDADVTYSFVLGQSSEGLVRAECRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLI8</accession>
    <name>D6SLI8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein-disulfide reductase</fullName>
            <ecNumber evidence="9">1.8.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868681.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2973"/>
    <dbReference type="EnsemblBacteria" id="EFI35549">
        <property type="protein sequence ID" value="EFI35549"/>
        <property type="gene ID" value="Dthio_PD2973"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055204at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase (NAD(P)) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087972" evidence="7">
        <location>
            <begin position="27"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="491"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="616" mass="69270" checksum="817018E986A9036B" modified="2010-08-10" version="1">MKRFYTQTALAFLVVLLFLSSGFSQDDRDFPMQSKWEVFAVDQEKTPGYQAMLLLWIIPDEGLYTYAHDPGPAGFPTVLTITDDPTESLEVFYPPGEEQPDPFDPSQTSEVFPEERTPIFIPLPADIPLEGILTAELSLLLCSDRNCWPVHKEIEFDLDRVDPAALDTAQEQDWWSMWQNAGPATQEPMMEMAPPAPADPDADETRWDFEVRSQTPGLEVDTLAKAALLAMIAGFILNFTPCVLPVISLKLRGMLTLEEDSGIDAQKRAFRKHNIFFALGMLIFFSVLAVVLSLTGMAWGQLFQSPGAILVLGCIIFALSLSLFGLYDLPVIDLKSRTRDPWKNPNAEALSTGMLATFLATPCSGPFLGGVLAWTLTQPPAIIGIVLWSMGLGMALPYLLMAVFPFMLRFLPRPGPWTMYLEKILGFFLLATCVYLMSLIPEDMFVKALIMFLVIAFAAWMWGHWTDLKQSNLRRRSIRLSALVLVALAAFLLFRPAPEHPVAWTPFEEQQFEEMLGRENILLEFTADWCPNCKFLEQTVLTPGFMAENAERYGLQFVRIDLTQPNPPGEEMLRALDSQSIPLVAIFSRDNPDSPLILRDMFTRSQIDQALEQELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLM7</accession>
    <name>D6SLM7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3016"/>
    <dbReference type="EnsemblBacteria" id="EFI35588">
        <property type="protein sequence ID" value="EFI35588"/>
        <property type="gene ID" value="Dthio_PD3016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="52" mass="5922" checksum="2891B6A89648E4C8" modified="2010-08-10" version="1">MSQDLHIFPVFASLEPEHTKALSGIAGTRHFKANRVFPASLREKFEGLGYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLM9</accession>
    <name>D6SLM9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c-type protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD3018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="9">Binds 4 heme groups per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Binds 4 heme groups per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NapC/NirT/NrfH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868719.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3018"/>
    <dbReference type="EnsemblBacteria" id="EFI35590">
        <property type="protein sequence ID" value="EFI35590"/>
        <property type="gene ID" value="Dthio_PD3018"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1683334at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019333">
        <property type="term" value="P:denitrification pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024717">
        <property type="entry name" value="NapC/NirT/NrfH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005126">
        <property type="entry name" value="NapC/NirT_cyt_c_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03264">
        <property type="entry name" value="Cytochrom_NNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000013">
        <property type="entry name" value="4_hem_cytochrm_NapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrom_NNT" evidence="11">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a menaquinol</name>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a menaquinol</name>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>a menaquinol</name>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000013-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000013-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="159" mass="17408" checksum="960D8346B9E6212C" modified="2010-08-10" version="1">MTKGKNRQNGAGRAAILIALLAGVALTLVAGFTYSHTDQPEFCGSCHVMYEATRTHQQSVHADLSCNECHAPHSAVPKMLFKSWAGTKDMYKNTFGKVGDVIQSSDRSSRVINDNCTNCHAMTGLNVDADMAKDQCIDCHRQVPHMRSTPVAERRVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLU9</accession>
    <name>D6SLU9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">Dthio_PD3089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868789.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3089"/>
    <dbReference type="EnsemblBacteria" id="EFI35660">
        <property type="protein sequence ID" value="EFI35660"/>
        <property type="gene ID" value="Dthio_PD3089"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1907955at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8619" checksum="4C0D34D7C179FD9A" modified="2010-08-10" version="1">MFGIGMTELIIILVIVLVIFGANKLPEIGAGMGKAIKNFKKATTEPEEIDVTPSEEKDKEQKKDKEGQEKEEEQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLV3</accession>
    <name>D6SLV3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868793.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3093"/>
    <dbReference type="EnsemblBacteria" id="EFI35664">
        <property type="protein sequence ID" value="EFI35664"/>
        <property type="gene ID" value="Dthio_PD3093"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="189" mass="21362" checksum="47C77C1A2F1E0F7C" modified="2010-08-10" version="1">MSQASIGKKIKKHRDMEEISLEELSRRSGLDTDFIRSVEEDDIYPSLGPLLKIARGLGVRLGTFLDDTVVQDPLIVREKDRQEELTMLKGKEKPAALRFYSLGKGKSDRKMEPFFIEVFPEPPQDKKLSSHEGEEFIIVVAGEIELVYGHETHVLKAGDSVYYNSIVPHNVSARGEGPARIYAVLYFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLW4</accession>
    <name>D6SLW4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine synthase</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Dthio_PD3104</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868804.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3104"/>
    <dbReference type="EnsemblBacteria" id="EFI35675">
        <property type="protein sequence ID" value="EFI35675"/>
        <property type="gene ID" value="Dthio_PD3104"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="15">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1e" evidence="16">
        <location>
            <begin position="341"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="13">
        <location>
            <begin position="176"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="776" mass="86822" checksum="5569EBE0F8CBFE8B" modified="2010-08-10" version="1">MSDLLSLIGNTPLVEIKALSPNPGVTILAKLEMSNPGGSVKDRVALAMIERAEKFEGLGPGKTVIEATSGNTGIGLAMVCALKKYPIKLIMPASASEERKMIMRAYGAEIVLTPGHLSTDGAIEEAYRLARDFPEKYVLMDQFNNPASIEAHYHTTGPEIWEQTGGSVTHVAACLGTTGTIMGITRRMRELNPEVRCIGIEPYAGHKIQGLKNMQESYPPGIYSKKALDRIIHVRDDDAWAMCRELARKEGIFVGMSSGAAMAGVQQLAREMQEGVLVTILPDGGERYLSTPLYSIPELDGIKIYDLQKRKKAVLQCSGKKPGIFTPGPRTNFFQDPDFWRRAVFLDVLCRRLAQKGHDPNPVAAVADFDDRTLECMREKGVSREDFSRETLDSIRDLAGRIKLNRNFNFLPAAGSLDTGIEMCNKLLSRGLAYEKLRCVYFDVGRDRDYGLLAGIDPEKIISGKTVDLEDYVKDSPRDFTLLKRASLKDLKEENVLKTKWGNVRPSWYLQMAAVAAENAGHLDLVMAGEAHLFPHLDNLLSIWKGSTSLRPQCWSLALPVHHQEKGEPLPGIQEMAREMGGFHPLRMWLMSVSYHRPLMFSPKNLEMWVKNWKRLQELMGKLKICARGTRPDKETGSEVEKQCRELGPALSGCLDDDLALYKFWPQLFEFCRKMQKLLDENLMDVRDAGSCLHHLQGLDSILKIIDWQALPLAENEYPVQISELLQARARAKEAKDFVAADELRDRALSSGFRLVDTRDGTRVYPAGSKENTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM57</accession>
    <name>D6SM57_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3199"/>
    <dbReference type="EnsemblBacteria" id="EFI35768">
        <property type="protein sequence ID" value="EFI35768"/>
        <property type="gene ID" value="Dthio_PD3199"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025455">
        <property type="entry name" value="DUF4276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14103">
        <property type="entry name" value="DUF4276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="224" mass="25339" checksum="FA2D6550228F503C" modified="2010-08-10" version="1">MLDVLVLCEGHTEREFCKSVVAPYIASRGVAVQGTLAGRPQQKRGGVKNWSVYRKELIRLARQRTGRHVSLLIYYFRMPHSWPGRDDASKQPLSSRGRYVEEALIDDLPELGGLFHPCVQLHEFESLLFVDPETTARVIQSVTGMTVSSQKITRELEEIKSSFAGQVEMIDDSPENAPSMRIIQLVSNYDKVACGVLTVQEVGLSTLRSKCPWLDRWLHRLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMG7</accession>
    <name>D6SMG7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3317"/>
    <dbReference type="EnsemblBacteria" id="EFI35878">
        <property type="protein sequence ID" value="EFI35878"/>
        <property type="gene ID" value="Dthio_PD3317"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1545767at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088246" evidence="1">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="227" mass="25692" checksum="BE8C02CE16A009F5" modified="2010-08-10" version="1">MKQLLLMILIMIPTMTGCAWVEENFEQTIDPRLDHVTIYQRPTLDKARQDVPVYPVSFAQQDLTAVFFPFYVHERSGGSTDTGRKIGHLFWRSWVGEEVFPSISYRDMQDAPGKTAARRMAGEKEADLYVLGQVNHYLYGGSQGSTSIALTINIYCVQTDELVWSMAHSGRIDNARDRDFVLVTRRTWMPQSPEYVIVKNLAHDMGQPVKAWTRGTQGSIPSAGPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMH1</accession>
    <name>D6SMH1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAP transporter solute receptor, TAXI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869011.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3321"/>
    <dbReference type="EnsemblBacteria" id="EFI35882">
        <property type="protein sequence ID" value="EFI35882"/>
        <property type="gene ID" value="Dthio_PD3321"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="991310at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088114" evidence="1">
        <location>
            <begin position="26"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="319" mass="35315" checksum="D74A121339BFD080" modified="2010-08-10" version="1">MFGKRIFIAVAAVLALALSAPQAKAKQDILFGGASIVGVYYQVALQISNIMNNEIGDKYNYIGRPTGGSVFNINALERGAFDFGVAQSDRNWQAYNGAAEWEGSPIKSLRSLFSMHPETVMLVTRQDTDIHSVEDIKGHRINIGNPGSGQRGNAMDVLEIYGIDPQNDFRAEGLEHHEAARALVDRNIDAFFYTIGNPSAAIEEPATSVDIRMIPINAQGIKDMVEEKPYYIMTTIPGGTYRGVDEDIETYAVTATVVSDEKVDEDVVYDMVKTVFENLDALRESHASFRHLEVEEMLQGLSAPLHPGAKRYYEEQGWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMH4</accession>
    <name>D6SMH4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869014.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3324"/>
    <dbReference type="EnsemblBacteria" id="EFI35885">
        <property type="protein sequence ID" value="EFI35885"/>
        <property type="gene ID" value="Dthio_PD3324"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="4">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="145" mass="16235" checksum="CF7F411F8F497BAA" modified="2010-08-10" version="1">MSEKKNILFLCTGNSCRSQMAQGWTNALQSENFQAFSAGVKKSSVDPMAVEVMGEAGIDLSGHYSKLIEELPGVKFDYVVTLCDHARESCPVFFSDAQKIHHGFDDPPYLARDAASRDEALGYYRRVRDEIKDFVQSFPQSLKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMJ8</accession>
    <name>D6SMJ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869037.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3349"/>
    <dbReference type="EnsemblBacteria" id="EFI35909">
        <property type="protein sequence ID" value="EFI35909"/>
        <property type="gene ID" value="Dthio_PD3349"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="402" mass="45297" checksum="5A041914DE1C6048" modified="2010-08-10" version="1">MNLSDLFAIQALLVGNLPATRRFLFERINWDNRLICLYGGRGVGKTTLMLQRLKDCEQEGGKGLYFAADHIQVTAMGIYDIAAEFFRHGGEVVFIDEAHKRPDWAQEIKSLYDSFPRGRLVVSGSSALAMQTGKYDLSRRAFYRMLPVLSFREYLSIVHGREYQPVTLETLLRDHQRLASDVLGSGQVLGHFREYIEAGAYPFVLEGKAEYLQRLENVIEKTLYEDLSLAEGRRSGGVRVMKKLLWLVATSPPMQLCIESVARDVGVSRPTVYDYLAVLERAGLLTTVPPHGHGARLVRKDSKIFLENTNLLWAISQSLTRTDPLGSLRETFFVNQLFSAAARIRVAARGDFIVDDTYTFEVGGKGKGFGQIEETQDGYVVRDGQEVGHGRILPLWLFGFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMK9</accession>
    <name>D6SMK9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3361"/>
    <dbReference type="EnsemblBacteria" id="EFI35920">
        <property type="protein sequence ID" value="EFI35920"/>
        <property type="gene ID" value="Dthio_PD3361"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="327" mass="35489" checksum="4881D31CE7B0C4B8" modified="2010-08-10" version="1">MISIIKRFFPESSFKHVKEGQAGCFNFSRNSTWSAWFQAARMPSQVYIFLPLLMGQAMAFTQGAFSWSVFLFCHLYGLAMQLFIVFANDVADEDTDRLNSTYTIFSGGSRVLADDCLSSRSLFSAAGVSALLCLLAGVLLAWFSSGWGPLLLVLLGLVLLWAYSFKPFRLSYRGGGELLQMLGVGGVLPMLGYLAQHGSLSGIYWPYMGLMLLLALSCAMSTSLPDEPSDRLSLKKSSSVLLGGRLNQRLILALNAGAFFLLALFMLHGLGYTGMYLIALLCLGLWFSGVLLLDQKPGSLGLSVFVASSVSFSLLPMAGVSMALFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMS1</accession>
    <name>D6SMS1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysine 2,3-aminomutase YodO family protein</fullName>
            <ecNumber evidence="8">5.4.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869110.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3424"/>
    <dbReference type="EnsemblBacteria" id="EFI35982">
        <property type="protein sequence ID" value="EFI35982"/>
        <property type="gene ID" value="Dthio_PD3424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="557227at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="80"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="370" mass="42440" checksum="14B6FB2D6EDCE868" modified="2010-08-10" version="1">MHTPQYINDINKVPGLTGRDLEQLAPVMDTFEFRSNEYYLSLVNWDDPDDPIRRIIIPSVQELDQWGRLDASNEQSYSVLPGLQHKYVSTAVFLASDACGGFCRYCFRKRLFIHPEQREVLTDLDAACDYVRNHPEINNVLITGGDGLMLSTSRLEKIISRLRGIDHVKIIRIGTKLLSYSPYRVLNDQELLEMVKKYSLPDKRIYFMTHYTHPREMTDVSLEACDRLIKAGGILCNQTPMLRGVNDDPQVLGELFNRLSYMGVAPYYIFICRPTVGNKPYAVPVEEAFNVYQNARSMCSGLGKRAKLAMSHASGKIEALAMTDENIIFRYHRAADPDESGKVHICTRNPRAYWFDDYKEIVETYEQQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMT6</accession>
    <name>D6SMT6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869125.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3439"/>
    <dbReference type="EnsemblBacteria" id="EFI35997">
        <property type="protein sequence ID" value="EFI35997"/>
        <property type="gene ID" value="Dthio_PD3439"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="275" mass="29294" checksum="A999245BE881B782" modified="2010-08-10" version="1">MLEILQYDFMRNALLAGFLVSIACGIIGAMVVVNRLVFISGGIAHASYGGIGLAFFAGFPPSLGAGLAALISALTMGLVSHSRKHRADTVIGVIWAVGMSIGIILLDLTPGYRVDLMSYLFGSILMVPASALWTMAGLSLAITVLVLIFYKDFLAMSHDEEFARAVGVPVTALYFLLLVMVAMTVVMTIQVVGLILVIALLTIPSYIAEKYSSSLKQMMLLAVIISVIFTQTGIWLAYYLDLTTGATVVLVAAAAFIISGLLPGRSIKDKAEHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN38</accession>
    <name>D6SN38_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869224.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3547"/>
    <dbReference type="EnsemblBacteria" id="EFI36099">
        <property type="protein sequence ID" value="EFI36099"/>
        <property type="gene ID" value="Dthio_PD3547"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI36099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="782" mass="89148" checksum="CCCA34B66616F243" modified="2010-08-10" version="1">MSEFAHLHCHTEYSLFEGCIRIEELCSKAAEYKMPAVSITDSGNLYGAMKLYSAAREYGIKPIIGCEINLVPGKVTDRDKFNYHLVLLAMDLRGYHNLVKLVSAGWLQGFYYKPRVDKDMLQKYSDGIIALSACLKGEVQYLLRAKGFDQGLEAAMQYARIYPDRFYLELEASGYNEQAEVNDRLMELSEKTGLPIVAANDCRYLTPQDAEAHAVLKCIKNAERLDEQDLDNLDTRELYFKSPEEMEKEFSYCPTALENVHKIVEQCNLDLDSPKRHLPRYKPTIEDTLDKELTALALNGLDEKLATLPYKVDREKYFTRLDKELKILCEQGKSWYFLVVYDYVAWARSRGIAVGPGRGSAPGCMTAYALGITGIDPILHKLHFERFCNTKRAGVVDIDVDLCQERRQEVFDYVFEKYGQNSVVYISVFICMRARTVFRDVSLVIGISPEQAERIIQLIPQEPGMTISKAMEMEPALRSIMNDNEKMQRCFDICTRLEGLIRHITSHAARIVISNENLQDYLPLYRGRNHELIAQYDYNDLERLGFPGFDLLGLKYLSLISRTLDLIKASQKQAPDMDSLPLDDAKTFVLIEQGHTDGAFQLEGDGFRQYLRELKPERLEDLAAMLALYRPGPLVSGMLSNFIKRRHGRVAAEYAHAELADILKETHGMIIYHEQVMTIAHKIAGFSLEDAEILAKNLVGKKPEALIQQKEKFIKGAMQKNNVPVKTAEQIFDMMKQAGPYGYLKAHSIAYAMISYQTAFLKANYPEEFQQAKDTVFGKNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN76</accession>
    <name>D6SN76_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869530.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1553"/>
    <dbReference type="EnsemblBacteria" id="EFI34202">
        <property type="protein sequence ID" value="EFI34202"/>
        <property type="gene ID" value="Dthio_PD1553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="873" mass="98144" checksum="AEED450C7D9AC792" modified="2010-08-10" version="1">MIHFDQHLRHLFLGQSYADFLSPGRFSAPWYQLWLSTKDNKEKKPLISENNGWVEARDLFSLRLEHDNAQYDILWWREVSGRWNSVNIAPGDYDSYVSDLFSHEPAWLRIWTGRNDGDGLKGSLVDVGHIYGPDAAPGWIKTEDLRKLKTDVSRLDHNEIWVKPAGGEWQSADIDFIYPVDFSSLQQINIMEHSYADLLDFKPFASEWYRIYTGDEHGAVPVQTGLANGWIQAGELAELTLSAEHSSHDTLWWKPQNGKWQSVSIGPQDTGLSFARLFTHAPGWVRIWTGNRSDDELTGSFVDTGHLYDHGEPGWILLSDLKLIEVDADRLDHDLVRIKPADGEWKERDVAFTADQLQPQLEAGFTGSELFHAGQEFSLELEVSESTGAEIENLAVHFRIAGLIDKVVEAGDPRWSGLDGNTRTIVFEDLLIQEPGIYNVQAQAFADNAQEAEFSQDITIAAQEFSGRREVSIEHISAGRVGSEIEVQAWASHLGRNGQAVFTLHQGDFSHSETIPLQWEQPISKPLSFTFNDTSSLNPGPVNMTVSLSDSGRSFSASQDFALYQHEEEFNWQWADVEQQPYDLIGHMLVRLEDSDKTSMGTGFLISPRHVMTNAHVLSSNSWESDLSELKAAEFYLGRQGATASQEQEDNLYQAVQAHMQRYKWDDHWPDTDMAIITLDREVDQNDGQGHFQWFWTSADDEERDLRGKEVTWSGYPARGVHQGEDDGEGLYFQWSSQGEVDSYRIGHPDYGAQSGGFKLAPDMYGSRGASGSPVFFQEDSGDYYFAGVYAGSGSSKAPLVSALDKAAYNWALSIVQKDGYFLEKELLEDMSSGPSPVQLDSLNQGEQHRENTEVDLMGVHEEPGGLPDSCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNA0</accession>
    <name>D6SNA0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869554.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1577"/>
    <dbReference type="EnsemblBacteria" id="EFI34226">
        <property type="protein sequence ID" value="EFI34226"/>
        <property type="gene ID" value="Dthio_PD1577"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1626243at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="29805" checksum="D9ABE81438465E97" modified="2010-08-10" version="1">MKQKHLFSENPLIIFTHIPRAGGTSMWQIFRSVYGERVKRISGKGPAGTREAVAKLLKSEPFGYDVLGGHVPCGIGQNCVNRPYQYFTVLRDPTNVVLSRYYKRTDPQVQQRKAYNQPGEFEENLRKMKNRSVMGPEEFIRKNNNPLIRFLSDDEIRTGENLITREHLEAVKSRLQKDYICLGFVERYQESVKLIAQALGWKKVPQAQQRNTGGNRPREYDSALVELGREINKLDYELYSFAEKLFDGWLKDSLTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNA9</accession>
    <name>D6SNA9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869563.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1586"/>
    <dbReference type="EnsemblBacteria" id="EFI34235">
        <property type="protein sequence ID" value="EFI34235"/>
        <property type="gene ID" value="Dthio_PD1586"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1945747at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9717" checksum="B39E00B173A93E4F" modified="2010-08-10" version="1">METRTLSFELPVGIFSALRKTPHELQRDMRIAAAAKWYEMGHVSQEKAAEIAGLCREDFLMELSKFNVSPFQYTSSEVLQEAGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNE7</accession>
    <name>D6SNE7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869601.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1624"/>
    <dbReference type="EnsemblBacteria" id="EFI34273">
        <property type="protein sequence ID" value="EFI34273"/>
        <property type="gene ID" value="Dthio_PD1624"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="365" mass="39777" checksum="375E3E84E71B7D45" modified="2010-08-10" version="1">MDFTFLCSGKPEPNGRKVAIIGSGPSGLSATGYLACAGYKVEVYDKLPKPGGLMVFGIPGHRIQPENIARGAEKLEKEFGVEFKLRTKICGSEPMHEETGDDMAYTYKSLGGRVEDNDAVLICTGTWKSRRMEIPGHELPGVYSGLEFLFPVRAASYEITNMDVPEIKGKKVVVIGAGFTAVDVVHAALTEGASQVNLVYRRSREEAPCGSMEFNMLEKQGAACMEHAAPLEIVGTDRVEGVRFAPCVMSEPDEAGKCRLTVQKEDSFIMDADIVVTAVGEMGTPPFAHDLGLDNVRKGEVKWLQMTSLDSVFVAGDVLMGPSKIGKAVYSGLKAAKSLDEWITLKDQGRLDEFQDEVIRREDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNI5</accession>
    <name>D6SNI5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869639.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1662"/>
    <dbReference type="EnsemblBacteria" id="EFI34311">
        <property type="protein sequence ID" value="EFI34311"/>
        <property type="gene ID" value="Dthio_PD1662"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033FES">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1955229at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="12579" checksum="2C5D77DE06C18395" modified="2010-08-10" version="1">MIDKSNIIPAILERLENLPHGHYLDMRTYKRNRYLLLVKKGDDDFLIIENGFFRERFEHVPFKKLKKLLKTLLKKEFPRSTKVRVYNMGIFEEQTAQNIERKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNN2</accession>
    <name>D6SNN2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1709"/>
    <dbReference type="EnsemblBacteria" id="EFI34358">
        <property type="protein sequence ID" value="EFI34358"/>
        <property type="gene ID" value="Dthio_PD1709"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1742337at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="8133" checksum="683042E8E78DE028" modified="2010-08-10" version="1">MSMLNNTRTGLPFFGLGYDMNSVTVFAYCMDYKKYYFSPIYKGWYHCIPVYCVSGYDLQIFLGRQIRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNQ6</accession>
    <name>D6SNQ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenine-specific DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1734"/>
    <dbReference type="EnsemblBacteria" id="EFI34382">
        <property type="protein sequence ID" value="EFI34382"/>
        <property type="gene ID" value="Dthio_PD1734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="34" mass="4127" checksum="D9D5B8E7CA81B439" modified="2010-08-10" version="1">MSIETRFDIPFVARLALREKQIQQNYRPIIGVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNR4</accession>
    <name>D6SNR4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869716.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1743"/>
    <dbReference type="EnsemblBacteria" id="EFI34390">
        <property type="protein sequence ID" value="EFI34390"/>
        <property type="gene ID" value="Dthio_PD1743"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50345S6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028323at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="282" mass="33056" checksum="C0D5CF628D27DF79" modified="2010-08-10" version="1">MTKEYERKKLYVLRRACWLGRARNSDLIERFEVTSATASKVLQEAINEWPHVLYQYRKSGVFKKEEAVTPKEASAETMIELFEKHAGPEDTGLTHEEASVFFVQYPPRNRPLSGLDIILEYVFKARQAYINPKDMRGQHIVIEILYVGLKKNDLPRWRKVVCNGLQHNGQVWRLLAQDINSPGYIQKHYVMSRIMDARPSPTSVPKDFEFKDVKAEKTKVEVIFNEELNNEQRQVLSNELGVKDGRITVPKNELFYFKRYYQDDKKNMGHVVWPLITYSKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNZ1</accession>
    <name>D6SNZ1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase-binding transcription factor DksA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dksA</name>
        <name evidence="8" type="ORF">Dthio_PD1826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts directly with the RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DksA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869789.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1826"/>
    <dbReference type="EnsemblBacteria" id="EFI34467">
        <property type="protein sequence ID" value="EFI34467"/>
        <property type="gene ID" value="Dthio_PD1826"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00926">
        <property type="entry name" value="DksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012784">
        <property type="entry name" value="DksA_RNA_pol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02420">
        <property type="entry name" value="dksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="7">
        <location>
            <begin position="40"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="13923" checksum="2537B0078977FFF4" modified="2010-08-10" version="1">MNQADIDSFREILRKMRQDILEQGEDTLEDMTGEREMYADPADRASAESDRAFTLRLRDRDRKLIKKIDEALERIEDGTYGECEDCGEDISKPRLKARPVTTLCIKCKSRQEQQEALHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP03</accession>
    <name>D6SP03_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">moaA</name>
        <name evidence="14" type="ORF">Dthio_PD1838</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869801.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1838"/>
    <dbReference type="EnsemblBacteria" id="EFI34479">
        <property type="protein sequence ID" value="EFI34479"/>
        <property type="gene ID" value="Dthio_PD1838"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="37567" checksum="F54A6D24DDC58D1C" modified="2010-08-10" version="1">MIQDNYGRGVSYLRLSITDRCNLRCFYCRPGKGSRFISHKNILTYEDMLYLLHAASGMDVQKVRLTGGEPFVRRDILYFLHRLKSELPQMEIRLTTNATLIAGKIRALRDIGIKGLNISLDTLDRDKYQRITGQDKLDSVMASIDRCLEEGIRVKINAVALKGVNDDELGDFIRLAMDKPLDVRFIEFMPIGEKTLWEQDYYWSSADLLTQAAELTDMVPVDNLTRNHGPARMYKPGHGLGRVGVISPLSAHFCATCNRLRVTANGRLRTCLFSDKEYNLLPLIRSPKISPERLRLVMERAGRKKPMGHELMSGGKKEKSLCRRVMSSIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP54</accession>
    <name>D6SP54_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1900"/>
    <dbReference type="EnsemblBacteria" id="EFI34530">
        <property type="protein sequence ID" value="EFI34530"/>
        <property type="gene ID" value="Dthio_PD1900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="43" mass="4892" checksum="2BF80DED02DCA503" modified="2010-08-10" version="1">MPERVRCERYIQKMIMALLFNLRLIVRGAGLQDAKCAGRTAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP58</accession>
    <name>D6SP58_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD linked oxidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869854.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1906"/>
    <dbReference type="EnsemblBacteria" id="EFI34534">
        <property type="protein sequence ID" value="EFI34534"/>
        <property type="gene ID" value="Dthio_PD1906"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="455" mass="48971" checksum="A892E2B76A814F7B" modified="2010-08-10" version="1">MSLKKSQVRDLGKILPNDGLLFNPAEKLIYGTDAGRRFAMPWAVVLPETVEQVRQIMHWAGQEKVPVIPRARGTNVVSACVPQAGGIVLSCLKLGRILSLSSRDFTAHVQPGVITHELQQAAAAKGLFYPPDPASVRICSIGGNIATNAGGMRAVKYGVTRDYVLGLEVVLPGGELISTGGKVHKNVVGLDLNSLMVGSEGCLGVVVGAWIKLLPRPAYASTIMACFESEEQALESVDQIFGAGLLPCALEFLPREVLQCLSAYSGMPWPDNAGAALMVQCDGLKGSVRQEMAEARKRLKEPVYVDEAENSDQERIWELRRLINPASFRLGSGKASDDVSIPRGSLLKAMQGIRRIAGNHSLQVLAFGHVGDGNLHVNFMYDDKQQVVQKEVQKARAELLELVLDLGGSMSGEHGVGLSKRGFLNRQPGLAALEIMRGIKKVFDPDGILNPGKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP81</accession>
    <name>D6SP81_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869877.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1929"/>
    <dbReference type="EnsemblBacteria" id="EFI34557">
        <property type="protein sequence ID" value="EFI34557"/>
        <property type="gene ID" value="Dthio_PD1929"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="4">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="32548" checksum="F53686536C04738D" modified="2010-08-10" version="1">MQKKEKGLGKGLDALIKPSFYEEKNTDSVQLSVQKVKPNPYQPRKNFAEESISELAASIQENGVLQPILVRKNENQEYEIIAGERRWRASIEAGLNTIPALVRDYDNNQVLAIALIENLQREDLNPMEQAYALQRLQSELGINQEELADRIGKSRSQLTNTLRLIKLPEKIRDMVEDRSLSPGHARCLLGIKDEELMLEAAGKIVSRNLSVRQTEELVKKLTQEKKKESRRNKSDFAGSLESRIKEKIENKLSVQTQGDEKKGKVVLQYRNENELDALLKCLGIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP89</accession>
    <name>D6SP89_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869885.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1937"/>
    <dbReference type="EnsemblBacteria" id="EFI34565">
        <property type="protein sequence ID" value="EFI34565"/>
        <property type="gene ID" value="Dthio_PD1937"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032BCF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1889169at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087902" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="146" mass="16858" checksum="90253B125A481FA5" modified="2010-08-10" version="1">MWKTLSVALMLLILSGCWATREPEPESFEPVTESQEPEQRETAAHGYYDFDDIPIPKEMNIDRDESILFESQGVKAGMLTYSGRVDSNSLFNYFLSALPNEGWEKLSYIKYGTQIQTFAKDDRLCIIRIIDGRLRTELQIWISPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPK0</accession>
    <name>D6SPK0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2048"/>
    <dbReference type="EnsemblBacteria" id="EFI34676">
        <property type="protein sequence ID" value="EFI34676"/>
        <property type="gene ID" value="Dthio_PD2048"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="126"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="351" mass="39091" checksum="E3A6A4B76DD62928" modified="2010-08-10" version="1">MTLGLYFLQYLICTASAMKIFLWLMILLVAGSGFNINQDGVYGAAYPYRPLDQSGGQSSLSPVIGFMQSHRIEQGETLLDIARKYGLGYNEISLKHPELDPWVPEEGLKIDIPTTWILPPTRHGEIVINLPEMRLYRFYRDIDMVRTYPVGIGRDGFETPPGDARVQKRVEDPSWTVPPSAREGFSRVVVPPGPDNPLGGYWIGLSRDSLGIHGTNFPWGVGRKVSRGCIRLYPEHIQQFFYDVEAGAKVEIIYEPVKLGLRGGDIFLEVHPDVYGKIADMHSHVWDLLQASGLAPWVDLSEAGRVLEEKKGVPAVVTNSDMPGFIPGDEWCLILSSTIQIKGGCICSENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPL3</accession>
    <name>D6SPL3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870009.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2061"/>
    <dbReference type="EnsemblBacteria" id="EFI34689">
        <property type="protein sequence ID" value="EFI34689"/>
        <property type="gene ID" value="Dthio_PD2061"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="22784" checksum="C3474AD8449DA47A" modified="2010-08-10" version="1">MPRVVFNKLEKLYQEMQNSYDQVAAETGFTCDGCPDNCCNSFFRHHTRVEWAYFWKGLEQCRPEIRREIVERAGEYVEQMNTDLSQGRDPLIMCPVNFDGWCVLYHHRLMICRLHGVPSTHTAPGGRSREFPGCFRCREKTEHLSHVPRLDRTRFYHQLAWLEQSYVGPKIVKMDRVNMTLAEMIMHGPPFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPV3</accession>
    <name>D6SPV3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2155"/>
    <dbReference type="EnsemblBacteria" id="EFI34779">
        <property type="protein sequence ID" value="EFI34779"/>
        <property type="gene ID" value="Dthio_PD2155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="32" mass="3658" checksum="F6BBB5AC252E3993" modified="2010-08-10" version="1">MNNIIKVLSIVARDPSAQKIAIEIIRRVLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ19</accession>
    <name>D6SQ19_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870159.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2236"/>
    <dbReference type="EnsemblBacteria" id="EFI34845">
        <property type="protein sequence ID" value="EFI34845"/>
        <property type="gene ID" value="Dthio_PD2236"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="217"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="455" mass="51669" checksum="5C450FF86DDDB015" modified="2010-08-10" version="1">MTPKRPKWPGITWRPCVRESGPWILGVNPWVYDFAAYNLWARPAGLLVCLDMLSKAGARTALMDCMDRTWQDQPWPAAGYTGAGRYPRTVLPRPGVLADVPRQYSRYGLPGDRVEKALARLDPPPDLILITSIMTYWYPGIVAAVRMLRRLWPGVPVCLGGVYATLCREHALRLDVDLVISGPLEDEDNWAKVWNLLGSSPPELPRDAGMSLDTSFYTQSGYSVIMGSRGCPFRCSYCSGYRLYPGFRQAEAGLLFEHIRREYMRGIRDFAFYDDALLVNARNLLIPLLDKIISSRMEIRLHTPNALHVRYLDLEVCRLFYRAGLHTIRLGFETGAFGSRPDRKLASDEWSQGMHNLLQAGFEKEQMAAYVLFGLPGQDNAEVLQSIREVRRWGIRPELTQYSPIPGSEMFEEAKNYTWLDLDDPLAHNNSIWPCVPGGFTWAKRNYWSRIAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ20</accession>
    <name>D6SQ20_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870160.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2237"/>
    <dbReference type="EnsemblBacteria" id="EFI34846">
        <property type="protein sequence ID" value="EFI34846"/>
        <property type="gene ID" value="Dthio_PD2237"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033CDW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2091403at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="64" mass="7479" checksum="CB44837476A472A4" modified="2010-08-10" version="1">MSTIMPEDKKVRQAVKWVDEGIQEGKSLDRLLGEAGMRFNLGPRDEEFLYKFFRKNEQGSDDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ81</accession>
    <name>D6SQ81_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">Dthio_PD2298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870221.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2298"/>
    <dbReference type="EnsemblBacteria" id="EFI34907">
        <property type="protein sequence ID" value="EFI34907"/>
        <property type="gene ID" value="Dthio_PD2298"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661843at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="281" mass="31595" checksum="8320E08DFBBBF116" modified="2010-08-10" version="1">MDIISSCSQVQQTCMQARHSGRTLALVPTMGYFHQGHLSLMRWAREYCDLLVVSLFVNPAQFGAGEDYQHYPRDLDSDVTAASEEGVDILFTPGQGSLYPEDYATWVEVEGMSGKLCGRSRPEHFRGVATVVCKLFNLTCPHKAVFGQKDWQQLIIIRKMARDLNIPVEVVGRPIVRQEDGLAMSSRNAYLDREQRKAAPMVYQGLLYARERFESGLTDPGQLERELERYYQKNLPQGEIDYVQIVDCNTLDRPDTLKPGALAAVALKLGPARLIDNILLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ85</accession>
    <name>D6SQ85_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2302"/>
    <dbReference type="EnsemblBacteria" id="EFI34911">
        <property type="protein sequence ID" value="EFI34911"/>
        <property type="gene ID" value="Dthio_PD2302"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033V5Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="270" mass="30850" checksum="F726C8C0A1A562D2" modified="2010-08-10" version="1">MANNLTTKVKDFLLSRSVQEHRELPNDFDLLEMPLEAVLAYWLSVGKVMSSRDASFLARERENTSEPFISHLLGLLGSSLAPEKVEKYAAVKKKTIIDDLQRKFVLMSISILGMATNENPQKVLIRIISKFSISPVYEKQIFEAAQAALSGLDQNEAHRKRFLNVDHRMKLESLILNLIIHNMLSRRLGGKELKEYISYVRSFYFAEGLSYIIDGFEYDFIKYRLNLQKKAILDLTETKMDMSLNLCSGIKAGMSYDDLKLVGSSYMLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQB9</accession>
    <name>D6SQB9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2337"/>
    <dbReference type="EnsemblBacteria" id="EFI34945">
        <property type="protein sequence ID" value="EFI34945"/>
        <property type="gene ID" value="Dthio_PD2337"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZQIU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="52" mass="6170" checksum="40B5AB3555BB5B18" modified="2010-08-10" version="1">MQERFCACGHKVYVAYVFTGRGIYHLFRPMARMRELMRCPSCGRRINIDELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQF3</accession>
    <name>D6SQF3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870293.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2371"/>
    <dbReference type="EnsemblBacteria" id="EFI34979">
        <property type="protein sequence ID" value="EFI34979"/>
        <property type="gene ID" value="Dthio_PD2371"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1092632at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="356" mass="39451" checksum="9B6F22A038A408B0" modified="2010-08-10" version="1">MAEAKYISQDKLGKWLDELSQQMQVLAPVQEGEAVVFRPYQTGTEIRLEGQPTLPPKEAVFPASEELFAYTYRKNPEDPAQTDVEIGPRAQPQKTLVFGARPCGSRGFVIFDPVYTQGYYMDPYYRVRRESTIFASVACVSHENSCFCHSVGSGPGDTAGSDILLTPVDNGYVAEAVTDKGGEMLGSSLLEAAGDKAGKARELRDKALKDMGEPRDFTPAREKLLAIFDDLDFWEDVSAKCISCGACTYLCPTCYCFNITDESAGMQGSRIRSWDNCMSFQFTLEASGHNPRPTKAHRLRNRVGHKFSYYPELHQGMIACCGCGRCIKHCPVSVDIREIVIRAMEHQTETGEEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQV2</accession>
    <name>D6SQV2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="9" type="ORF">Dthio_PD2522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870442.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2522"/>
    <dbReference type="MEROPS" id="S16.A04"/>
    <dbReference type="EnsemblBacteria" id="EFI35128">
        <property type="protein sequence ID" value="EFI35128"/>
        <property type="gene ID" value="Dthio_PD2522"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="62"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="348"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="249"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="448" mass="48121" checksum="353117268ADB5758" modified="2010-08-10" version="1">MKTRTIHVCTSCGSSAMRWQGQCPGCGEWNTLEARSGSTQGKTQNVSPASRPSRLSSVDLTRADHMPTGMQELDDVLGGGLVPGGVVLLGGEPGIGKSTLLLQLLSLAGTKDGHTLYISGEESLPQIRSRAQRLGLDQENLQAMATGSLEDILAALSSHGPYQLVIIDSVQTISSSESDSMPGAPTQIRQVSSSLIKAAKESGTCIFLVGHVTKEGQIAGPKLLEHMVDTVIYLEGDKEHLFRILRVIKNRFGPTDELVMFQMGALGLEVIQDPSTFFLQARDPALSGTAVVMAVDGHKPFAVEVQALATPSFLSIPRRTALGFDLNRLHLLLAVMEKKLQRSLAQSDIYTKIGGGLKLVDPGLDLGLVAAVLSSFHNQSLPERAIFWGEVDLNGQIRPVLGQDIRLKQAFRLGYKPVFCPRSPESDTGISTIMELQDMLFGSNNPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQV7</accession>
    <name>D6SQV7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35133">
        <property type="protein sequence ID" value="EFI35133"/>
        <property type="gene ID" value="Dthio_PD2528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="32" mass="3665" checksum="B32ACC2B86DBC5D0" modified="2010-08-10" version="1">MDAYNQLEGKDVLAGRPAKLPFTLSRIRYIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQX9</accession>
    <name>D6SQX9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870469.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2551"/>
    <dbReference type="EnsemblBacteria" id="EFI35155">
        <property type="protein sequence ID" value="EFI35155"/>
        <property type="gene ID" value="Dthio_PD2551"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1594787at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="9"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="207" mass="23583" checksum="DB0665A7A0885001" modified="2010-08-10" version="1">MRDTESLPISALQHYLYCPRQCALIHVEMVWEENLFTAEGRLLHKRVDAGEAGRRGSIDEERSVPVRSERLGLYGVADVLEMRTGASGSSIPYPVEYKRGSPKVGDWDRGQLCAQAMCLEEMLELTIREGAIFYGRPRRREKVIFDDVLREKVEVSCRAMHSLIEGGVTPPPEHGRHCKNCSLLRVCMPKLSKQRKVEKYLLQGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQZ1</accession>
    <name>D6SQZ1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="3">dTTPase/UTPase</shortName>
            <ecNumber evidence="3">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="3">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2565"/>
    <dbReference type="EnsemblBacteria" id="EFI35167">
        <property type="protein sequence ID" value="EFI35167"/>
        <property type="gene ID" value="Dthio_PD2565"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="213" mass="23301" checksum="65794FB5CA51B3EC" modified="2010-08-10" version="1">MNTDNYLLAQGPFRTAREIILASASPRRQMLLSSLGLDFRVVPADYKEPPIRSGQDPEHYALEMSSEKCRIIAEKNPDSVVLGADTIVVLEKEVMGKPGSREHALEMLERLQGNVHEVITGVCLRCESWQVRESFSVASRVEMIPAGQDILEAYINTGEPRDKAGAYAIQGVGAFLVSSVHGSYTNVVGLPLDRVTQALLHIKAIHAAGDNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR59</accession>
    <name>D6SR59_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0498"/>
    <dbReference type="EnsemblBacteria" id="EFI33175">
        <property type="protein sequence ID" value="EFI33175"/>
        <property type="gene ID" value="Dthio_PD0498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="36" mass="3993" checksum="EF310203F9BD65AC" modified="2010-08-10" version="1">MHVFADGISKVTLSNGNLRIMLTNVEQMIPQLRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRC1</accession>
    <name>D6SRC1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE</fullName>
            <ecNumber evidence="6">2.1.1.163</ecNumber>
            <ecNumber evidence="6">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Demethylmenaquinone methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ubiE</name>
        <name evidence="7" type="ORF">Dthio_PD0563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="6"/>
    <dbReference type="EC" id="2.1.1.201" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870595.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0563"/>
    <dbReference type="EnsemblBacteria" id="EFI33237">
        <property type="protein sequence ID" value="EFI33237"/>
        <property type="gene ID" value="Dthio_PD0563"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043333">
        <property type="term" value="F:2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="235" mass="26742" checksum="A2C978B9EF7193D6" modified="2010-08-10" version="1">MTDSRHSRKVAGLFSSIAPWYDFLNHFLSLGQDFYWRRRLAGHIRLADQGTAADLAAGTMDVTKEILRHNPGSQVLALDYTRPMLVRGQHKLEKYRQDFLPVQADGRYLPLPDASVHCVSIAFGIRNIVPRIQACKEILRVLRPGGRLCILEFGTGKKRIWGGVYNFYLSRVLPLLGRLISRDREAYTYLAQTIAGFPDEDRLSRELKQAGFSRIFYYPMCSGIVYVHVAQKPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRD8</accession>
    <name>D6SRD8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870612.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0580"/>
    <dbReference type="EnsemblBacteria" id="EFI33254">
        <property type="protein sequence ID" value="EFI33254"/>
        <property type="gene ID" value="Dthio_PD0580"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ZB6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1445137at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="20153" checksum="F9434E455BF7680F" modified="2010-08-10" version="1">MKLLEARKIDPQISFDLPTYMALAQTGDLDGPEVAEMLGYWEQWSPALSIYIFGRKKGYLAVFMDRSVEEKIDEIWPDSPSKGFKLQALVQTMITCALQELIPSIGRDQCAPVPKPNKIMKRSLSRVGLEFSNQGTLNYKYSTLTFYPYKNGCQVCYLAPTCPKLNLPRMEGLFNPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRI3</accession>
    <name>D6SRI3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CULT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870657.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0625"/>
    <dbReference type="EnsemblBacteria" id="EFI33299">
        <property type="protein sequence ID" value="EFI33299"/>
        <property type="gene ID" value="Dthio_PD0625"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503301B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1981238at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15777">
        <property type="entry name" value="CRBN_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034750">
        <property type="entry name" value="CULT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51788">
        <property type="entry name" value="CULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CULT" evidence="1">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="14927" checksum="F9082802EE37B315" modified="2010-08-10" version="1">MYDLLKEEPGKDFSPDAASLEETREFQSRPNLLCSGCLSRITSQDAGISINGSQKHVFVNPHGLVFEVGCFSWAVNCLGTGPSTAEFSWFPGFTWQIAVCISCLMHLGWRYSSGDSGEFYGLIMDRLILDTSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRK4</accession>
    <name>D6SRK4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1638 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870678.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0647"/>
    <dbReference type="EnsemblBacteria" id="EFI33320">
        <property type="protein sequence ID" value="EFI33320"/>
        <property type="gene ID" value="Dthio_PD0647"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1062007at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012437">
        <property type="entry name" value="DUF1638"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07796">
        <property type="entry name" value="DUF1638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1638" evidence="1">
        <location>
            <begin position="47"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="28728" checksum="08DC8996E8ED34DE" modified="2010-08-10" version="1">MLKGEDTGEDIGVESRSPRVVIACGALRPELEHLRQGREKEVQTFYLPQNMHRAPHQLPELIQEKVDHASKYASKIILGYGLCSNGIVGVQAPEQGLVITRSHDCVALFLGSLEKYRQISRDHPGTYYLTRGWLDEGKDPLGTMENEYIPRLGRAWAEWGAREEIKHYTRFVFINTGVGDIEAMRERSMENARFFHKEYQEVQGDLEYLRRIMFGPYDKEYFYLVPAFEKVQQRWYVLDDAEPQPANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRP5</accession>
    <name>D6SRP5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase with PAS/PAC sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870719.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0689"/>
    <dbReference type="EnsemblBacteria" id="EFI33361">
        <property type="protein sequence ID" value="EFI33361"/>
        <property type="gene ID" value="Dthio_PD0689"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="348"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="494" mass="56981" checksum="6A55DE8A3E036B9C" modified="2010-08-10" version="1">MDNKKQAETDKNSPFSSRPVVRLEAPVLPHYVRTLLDELELSIILLNENDRITYINQTVMDFLGLKEEQLQSLRESPFYLLGPLSHIYESYKQKKVPQKFEYIPVNLGNDRQKYISGFIRPVYKDDFFLGTLCTFLDITDLIQSKDFLIDYFLSLESTLARKTKNLVKQNTKLQQELKKHFADKKELSSSLKHMQKIFHRLNYGTCRFTPDGMLLEANRALSAMLGFSSPQELMDAVNLQGWEIFHDQELWQLTTEEIIKRKKIIRIEAQLNLKKKTALWAEISAFSVTTKRGQTVLDMIFSDISKRKENELLLYSKSTMDPLTGIPNRALWSDRLDQTVKKARRYSESFAVIYLDLDGFKEVNDRLGHEYGDKVLITVSRRLQKKIRESDTLARIGGDEFCILVNNIKKANLSRMARSIIDSLTRPIKVNKSQPQVGVSIGICLFDDPDLTSAEIMHRADKAMYMAKTRGGNRYMIHGNDASGQQDQPEPSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRZ9</accession>
    <name>D6SRZ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870817.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0799"/>
    <dbReference type="EnsemblBacteria" id="EFI33465">
        <property type="protein sequence ID" value="EFI33465"/>
        <property type="gene ID" value="Dthio_PD0799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="48537" checksum="8FB743D54D405E4B" modified="2010-08-10" version="1">MKMHLIYPRWPKLERQTEFHLPPHGPVVFAAEVPDGVEIDFTDDNLEDLYFDPAADLAALSVMLTCQLPRAFAIADRYREMGIPVIMGGIAVSLHAEEAAGHADSLFLGEVEGRFGQVIQDLRAGALRRRYDYLNSPPEISMVGTARRSLLQRELYNYRGVQMVDLVHASRGCRFNCMPCCVGYLGGNSFRPRPLDRVIREVESIPNNRLFFVDNSLAQDREWLKEFFTAMIPLKRKWISHPVLYDPEILDLAARAGCWYVYQAVIDDSKTIRERIRMLKDHDIGIEGTILLGMDDHNESYIKRMVDFLIKEDLDMAEFTILTPFPHTPIRRKLEKQNRILSNDWNKYTCDRVVFQPKQMSPDKLQELYYYAWDAFFGQGGHQLRMANLFKKVIGKEMDDGTYRRYDPKRKRAFPGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS20</accession>
    <name>D6SS20_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870838.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33486">
        <property type="protein sequence ID" value="EFI33486"/>
        <property type="gene ID" value="Dthio_PD0820"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2041743at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11292" checksum="1781B7BBECBA1142" modified="2010-08-10" version="1">MTLWTIASLAILLGIALALLGIKVRRSARMHEMFFPGLQTGKKSSKKEQELAKRLLGLVHGREDVARRLVELEQSRNPEKSRKWCLNKAIESLKRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS39</accession>
    <name>D6SS39_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870857.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0839"/>
    <dbReference type="EnsemblBacteria" id="EFI33505">
        <property type="protein sequence ID" value="EFI33505"/>
        <property type="gene ID" value="Dthio_PD0839"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="16269" checksum="32108F139C8814C5" modified="2010-08-10" version="1">MKKALAAIIFVGAVFAIIFTYTHQMEQESAAIMESITQEGRVTMLNVGAEFCPPCQAMEPVLKEVQEHYQDQVHMPYLDMQKHSSQVQHLGVQTTPTQIFFDHQGEEVYRHEGILEKDEIKDKLDELLEKNTARLPGLSPAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS43</accession>
    <name>D6SS43_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870861.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0843"/>
    <dbReference type="EnsemblBacteria" id="EFI33509">
        <property type="protein sequence ID" value="EFI33509"/>
        <property type="gene ID" value="Dthio_PD0843"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50345RY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1892591at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8790" checksum="A8A8A1B8C1192F4B" modified="2010-08-10" version="1">MSEPSFIPPVKPVGMELVMFYPCPYCGRNVPLLAPTEASMGSCDFCRKQFPLVPIDNTTVQYIKLILHNGQAAIDPEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS56</accession>
    <name>D6SS56_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870872.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0856"/>
    <dbReference type="EnsemblBacteria" id="EFI33522">
        <property type="protein sequence ID" value="EFI33522"/>
        <property type="gene ID" value="Dthio_PD0856"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="442" mass="47218" checksum="2D60DC69F1ABD76F" modified="2010-08-10" version="1">MDLDPRQVRLYIAPLLSLTIFLSVLNGVTFNLAVPDIAADYAVSPAMVSWVVTAYIVIFAFGSVMYARLGQRFHLRDLITAGLLIFCLGSLLGFFTDSYHMLVAARMIQAAGASGIPALSMVLATVYVPVHIRGRLLGLIASTVAFGLGIGPIIGGLIAGYLHWNYLFLMPLLLLPSIYLLRRALPRQSDLVRKPLDLPGALLLAGTVGCLLFMVNLVMWWLLLPALVLGTLFARRIISISYPFVSPELFGSPGYLHGLLTALLAMGTIFATFFLMPLMFRHIYDMPTLHIGLYLFPGAMSAALAGLVAGRFVDRCGAAPVVRTGFLILMTGFCLIILTAGQSPVVSALCLIVANSGFTIIHSSLAGAVSGTLPDGRVGLGMGVFNLVFFVSGALGTASAGMFLDVLGQDQSGSYSFIFAGCLALALAALFIFKRSFTQTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS59</accession>
    <name>D6SS59_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="6">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ispG</name>
        <name evidence="7" type="ORF">Dthio_PD0859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0859"/>
    <dbReference type="EnsemblBacteria" id="EFI33525">
        <property type="protein sequence ID" value="EFI33525"/>
        <property type="gene ID" value="Dthio_PD0859"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="355" mass="37978" checksum="2C0251C852E23ECD" modified="2010-08-10" version="1">MCMQRRKTREINIGNVGIGGDNPIRVQSMTNTPTRDVQATLKQINSLVRAGCELVRLAVPDMESALSLPGIKSRSPVPLIADIHFDHRLALKSLEAGMDGLRLNPGNIGGPGKVSSVVQEAGKRGVPIRIGVNSGSVEKKLLDKYGGPVPEAMVESAMGHVRLLEEQGFELIKVSLKSSSAPDTIKAYSLMADERDYPLHIGITEAGTPLRGAAKSGVGLGILLHLGLGDTLRVSLTGSPVQEMTVAWEILRSLGLRQRGPEIISCPTCGRTEIDLPALAQAVEDRLRDVDEVFTVAVMGCVVNGPGEAREADIGLAGGRDCGIIFRKGEVVRKVRGKELIPEFMAELDRFLGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSB0</accession>
    <name>D6SSB0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 4</fullName>
            <shortName evidence="6">EF-4</shortName>
            <ecNumber evidence="6">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lepA</name>
        <name evidence="8" type="ORF">Dthio_PD0911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870926.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0911"/>
    <dbReference type="EnsemblBacteria" id="EFI33576">
        <property type="protein sequence ID" value="EFI33576"/>
        <property type="gene ID" value="Dthio_PD0911"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="600" mass="67724" checksum="3D909C157F2304E5" modified="2010-08-10" version="1">MVKQENIRNFSIIAHIDHGKSTLADRILELTGLLTDRDKKEQYLDRLELERERGITIKAQTVRIPYRARDGQDYILNLIDTPGHVDFSYEVSRSLAACDGALLVVDATQGVEAQTMANVYLALDHDLEIIPVLNKIDLPSADPLRIAEEIEEIVGLDCSDLSLVSAKTGEGVADLMEKIVHLTPAPRGKKDDPLKALIFDSWYDSYLGVMVLFRILDGSIQRGQEIMMFSNRKRFEVAKLGIFSPGPMDTDCLYTGEVGFLCAGIKDLKEARVGDTITNPARPADSPFPGFKRVQPMVFCGLYPVESEDYDGLKNALERLQLNDAALEFEAETSQALGFGFRCGFLGLLHMDVIQERLEREFQVSLIATAPSVVYKVHRVDGEVLEVDNPANLPPVQEIDEVREPYVRMEIHVPNEFVGNVLSLCEEKRGQQKDLRYLSSTRVIITYEIPFAEIVFDFFDRLKSVTKGYASLDYEVLDFRRADLVKMDILINQEPVDAMSVIVHREKAYHKGRSLALKLKRVIPRQLFEVIIQATIGNKVIARERTPPMRKNVTAKCYGGDITRKRKLLEKQKEGKRRMKKMGSVEIPQEAFLAALSSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSL3</accession>
    <name>D6SSL3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871028.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1015"/>
    <dbReference type="EnsemblBacteria" id="EFI33679">
        <property type="protein sequence ID" value="EFI33679"/>
        <property type="gene ID" value="Dthio_PD1015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="7717" checksum="A82A8D36B12A0ED3" modified="2010-08-10" version="1">MDIQGFSVGGGLTALNNSLQNHELGQELIQKTLNETEAAADAQTAPQAAPQPAQPAQAEAGAANAEGQGTMVDKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSR0</accession>
    <name>D6SSR0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871075.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1065"/>
    <dbReference type="EnsemblBacteria" id="EFI33726">
        <property type="protein sequence ID" value="EFI33726"/>
        <property type="gene ID" value="Dthio_PD1065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1426624at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="312" mass="34067" checksum="5D86961B23DAF4DE" modified="2010-08-10" version="1">MWKLFFKGFGIGAASIVPGLSGGTIALILGIYTRLIGIAGNIDHRTLAGLMRLVVRGRFARAFEYAVQTWQLHFVVPIGAGVLVAIFSTASLINFAVLNYRGFVFSFFFGLVLVSIYYPLKRAGRIRFKEVLVFFLAGTLILLAQLSPLWSDMQGFSNIGDLRFFLGGAVAMATMLLPGFSGSFMLVVMGVYFEILAAVAGMDLKIISLVGMGCVFGLISLAKVINYLLKNYYTTTMSFLAGLMFGSLAALWPFQKQVEINEDKVVTAGYALPESLAQGWPYFVCFLAGAGLVAVFILMDLTTGRHNRDETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SST1</accession>
    <name>D6SST1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871096.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1086"/>
    <dbReference type="EnsemblBacteria" id="EFI33747">
        <property type="protein sequence ID" value="EFI33747"/>
        <property type="gene ID" value="Dthio_PD1086"/>
    </dbReference>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020942">
        <property type="entry name" value="Cyt_c_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02085">
        <property type="entry name" value="Cytochrom_CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrom_CIII" evidence="4">
        <location>
            <begin position="50"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="16738" checksum="69398CB81CBC3B41" modified="2010-08-10" version="1">MKRSLVVGVLIIFVLGFLALPTLYAGLTYQHEGYYPEDMMLYPPVEYEEKYGEKRLAPVPFSHDVHFDYDCEYCHHTGDTHMGCMESGCHDMYENEPVEDVIMAGTRMQGDIFYFEDAYHEMCMDWCHRDEENAPTSCIGCHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSU1</accession>
    <name>D6SSU1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malate dehydrogenase (Oxaloacetate-decarboxylating) (NADP(+))</fullName>
            <ecNumber evidence="7">1.1.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.40" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871106.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1096"/>
    <dbReference type="EnsemblBacteria" id="EFI33757">
        <property type="protein sequence ID" value="EFI33757"/>
        <property type="gene ID" value="Dthio_PD1096"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="163"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="439" mass="47976" checksum="5E3D6CE74781A4BB" modified="2010-08-10" version="1">MPLFTPRESLDYHSMGRKGKLEVVPAKPCTTQKHLSMAYSPGVANSCLEIARDPDQVFSYTNKGNLVAVISNGTAVLGLGNIGPLAAKPVMEGKGVLFKAFADIDVYDLNINQSDPEKFIQWVKMVEPTFGGINLEDIKAPECFEIEETLIREMDIPVFHDDQHGTAIISGAGLLNALEITGKNIQDIKMVVSGGGAAAISCCRFYVSMGLPAENIFMYDTRGLIHQGRSDLNPYKKQFAQANDAGSIKDTLKGADVFIGLSVKDLLNRDMVRSMARPAIIFAMANPDPEISYHEAKAADPECIMGTGRSDFPNQVNNVSGFPFIFRGALDVRARGINEDMKLAAARSLAALAKEPVPEEILEAYGVGEMSFGPDYVIPKPLDPRIVEWEAPAVARAAVQSGLARTGIDMDSYQQSLKTRMAESQKRIREFIRSYSLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST28</accession>
    <name>D6ST28_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871193.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1183"/>
    <dbReference type="EnsemblBacteria" id="EFI33844">
        <property type="protein sequence ID" value="EFI33844"/>
        <property type="gene ID" value="Dthio_PD1183"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033FIC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926676at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10967" checksum="27C28704D9A018C0" modified="2010-08-10" version="1">MKEVTVLIRDPEQQYEGLRTSLGLLLHATGVNMVMLDHEIAQLDEAFEDNMGFLDEMEGERYSNNQANVDKYEFKPIDKEGIYELVKKSDIVIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST33</accession>
    <name>D6ST33_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="4">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Spermidine synthase</fullName>
            <shortName evidence="4">SPDS</shortName>
            <shortName evidence="4">SPDSY</shortName>
            <ecNumber evidence="4">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">speE</name>
        <name evidence="8" type="ORF">Dthio_PD1188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1188"/>
    <dbReference type="EnsemblBacteria" id="EFI33849">
        <property type="protein sequence ID" value="EFI33849"/>
        <property type="gene ID" value="Dthio_PD1188"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1446183at2"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4 5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="213"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="4">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Spermidine binding" evidence="4">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="797" mass="86969" checksum="7CC10036C3F708C1" modified="2010-08-10" version="1">MLGVISQIGQVLLLRELLMVFHGNELSIGIILSAWLAWVGLGSRLGARVVDRWGRPVFLLKTTAAAVLLLLPLTILTIRTLRGFFDVLPGAYLTLPEMLVSCFIVTAPVCLLTGSQFVLLSRVWRERDKSLDTTGAGKTYVGEATGNMLGGILFSFVLVHLLNPFQTSMLVAALMLAAVMLIVPARPSLRPRALAAVPIVLAAAVLLFFSLDHLDRFAHQIQWKQTAPQHQLVDTHESKHGNIAVLKRQDQYSFFQSGHLIFSTAGPETLVPGLEGQEAVSFAHLAMVQHQDPERVLLIGGGLRGTLAEILKHPVGKIDYIELDEKLVQTAAAHVHPGSLEVLDDPRVNLMHTDARLFVKRAGQEYDMIIVDSPDPSTAAMNRFYTREFFEEARKSLNPQGVLVAGTASTPDLRGTAIANRNTAVFHTLDRVFSHTLVAGDRFMFYFASDDSDQISVDPARLQERYTQRGIEAQGFSPVHYQVLLEESQLRRVNWVVRHHGRSPESHLEGPPSVPVSPGPVKQQARAQKDLDPVQDRYFLNTDFRPITYFYTLMHISDLTRRDGADILKHLLHVQPWWILPFAGATLLAACVLRFLGAKTGTRPDTTFAVTGSAFSTGLSTMVLQVGLLFSFQNIYGFIYELVGLIVAMFMLGLALGAFISHGLGPRRTTLGTLLMVQGIMALLAGLMGAALPLAAAVQPPWLIFALFSALTFSAGLINGVNFPLAAGCFMKLCRRPEHSAGRIYGAELFGACLGAVLASALIAPVLGIVACCLLAATANATAFAVLWISRREEPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST40</accession>
    <name>D6ST40_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1195"/>
    <dbReference type="EnsemblBacteria" id="EFI33856">
        <property type="protein sequence ID" value="EFI33856"/>
        <property type="gene ID" value="Dthio_PD1195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087952" evidence="2">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9148" checksum="DD004BE49A6D8C4B" modified="2010-08-10" version="1">MWIKGTLLTLAAVLVLGFSMGCEPEQEMDAPEGFEEQAPPEGYDQPAPEGYGEPAPDAYEQPAPEGYEQPEGEDPYGDPGEEPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST49</accession>
    <name>D6ST49_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871214.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33865">
        <property type="protein sequence ID" value="EFI33865"/>
        <property type="gene ID" value="Dthio_PD1204"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="112"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="351" mass="39828" checksum="FD6AA6F81E696342" modified="2010-08-10" version="1">MITRRNFVKGVFATAGTFFFAGCSEAGNPGVGNSEWTPAYARLEEEGRLKDRVDEAYARLEKCTLCPHKCGVNRLDGEEGFCRAPGRAVVHSRSPHFGEELPLVGDNGSGTIFFSNCNLRCVFCQNWPIAHEGRGREVEDEELAEMMLDLQRRGCHNINLVTPTHVMPNILSATRIAMKNGLNLPLCYNTGGYELVENIELLDGIVDIYLPDLKFMGSDESAKYVLEGRGDYPEMAQDSIIEMNRQVGVLEKDERGVARRGVMVRHLVMPNRVAGTREFVDWVAENLPRDTYVNIMSQYRVEHMAFEYDKIARSINSREFVEAMDWAKEAGLTNLDERSMSQYRLHRRRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST55</accession>
    <name>D6ST55_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylylsulfate kinase</fullName>
            <ecNumber evidence="7">2.7.1.25</ecNumber>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="7"/>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871220.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1210"/>
    <dbReference type="EnsemblBacteria" id="EFI33871">
        <property type="protein sequence ID" value="EFI33871"/>
        <property type="gene ID" value="Dthio_PD1210"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="6">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="5">
        <location>
            <begin position="172"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="570" mass="65186" checksum="FDB2699826BFC2A9" modified="2010-08-10" version="1">MSTENTANFYSENLLVHFRRIDRLKQEAGVYLSMDLNQRQLCDLELLLNRAFYPLVGFMNRADYESVLDNMRLTDGTVWPMPVCLDVPEAVAQKLHPGEPLALRDEEGFMLAVLTVQEVWMPDLKRHARAVFGTSRPDEHPGVGKLFQEVHPWFVGGTLEGLHLPLHYDFADLRTSPAQTHRIFTQRGWRNVAGFQTERHLHCAHREMILRGAREAGANLFIHPVVGRAGPNDLDHFTLVRCYQEFITNFPRNMVQLGLIPLERRLAGPRQALFEAIIRRNYGCTHFMISQDHGDPFAGDSRERFYPQGAAQELTKSLEDEIDIKMIPLQQMVYVEDKAQYFPVSQVEPDMKTKEISSAELKRRLEFDLEIPEWFSFPGVVQELKKAYPPRHRQGFTVFITGLSGAGKSTLAKVLYVRFMEMRERPVTLLDGDIVRKNLSSELDFTRAHRNLNVQRIGFVASEITKNRGIAICAPIAPYEESRSLARDMITPYGGFVEIFMSTPLDICEQRDRKGIYAKARSGAMKGVTGIDDPYEPPRNPEINIDTTNLTPTEAAQEVFLFLEEQGYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6STA6</accession>
    <name>D6STA6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliE</name>
        <name evidence="4" type="ORF">Dthio_PD1261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FliE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871271.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1261"/>
    <dbReference type="EnsemblBacteria" id="EFI33922">
        <property type="protein sequence ID" value="EFI33922"/>
        <property type="gene ID" value="Dthio_PD1261"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1581972at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34653">
        <property type="entry name" value="PTHR34653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="11535" checksum="2738DD4C782D5C14" modified="2010-08-10" version="1">MSVSPMALKAYTDAMQTGQNMAGGKAASGSNKAYNDFADTLQSSLGEVNNLQTDKKEMIEAFASGKTQNVHELMISLEKAGVAMQMTSAVRNKVMESYRELMQMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6STD4</accession>
    <name>D6STD4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="19" type="ORF">Dthio_PD1289</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871299.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1289"/>
    <dbReference type="EnsemblBacteria" id="EFI33950">
        <property type="protein sequence ID" value="EFI33950"/>
        <property type="gene ID" value="Dthio_PD1289"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFI33950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="273" mass="30339" checksum="47FDD55178CF2816" modified="2010-08-10" version="1">MPELPEVETIAAGLAPLVSGRSIRDIFLMQARVVRGDELEFQRRLLGRKVLDVRRRAKLLILDLDGPLHLVFHLKMTGKVWVPDKGVQPGKHTHLILDLGDEVYVFFDDQRRFGYVTALTPPELESWDFYRGLGPEPLHLSSQDFTDIFQGRKARIKSLLLDQQVIAGIGNIYADEALYMAGIHPCTRAVDLSGDQLEALHCSLQQVLQEAIQAGGSSFRDYRNALGVAGLFQENFKVYGKKGLPCPECGANLESTKVAGRSSCFCPQCQTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6STL7</accession>
    <name>D6STL7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FBPase class 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871382.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1372"/>
    <dbReference type="EnsemblBacteria" id="EFI34033">
        <property type="protein sequence ID" value="EFI34033"/>
        <property type="gene ID" value="Dthio_PD1372"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="879338at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="329" mass="35114" checksum="043C518C00A83DB3" modified="2010-08-10" version="1">MNQEEPQRNLALDLVRVTEAAALASSRWLGKGDNKKGDMAAVDAMRLSFNAIEIKGVVVIGEGEKDKAPMLYNGESLGTGNGPGMDVAVDPVEGTKLLAYGRPNAISVVALAPRGTMYDPGPAFYMQKIAVPSQAREHVDINAPVQDNLKAIASALGKSVDDLVVFVLDKPRHKQLIEDIRQAGARIQLHTDGDVAGALMAVSPDGDVDVMMGTGGTPEGVLTAAAIISMGGEMQCRLDPQSEQEKENLLSAGYDLKRVLTVRDLIQSEDVFFAATGISGGTFLQGVSFTGQGALTRSMVMRGKTGTLRRIESLHSFEKLMRISAIKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6STN7</accession>
    <name>D6STN7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871402.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1392"/>
    <dbReference type="EnsemblBacteria" id="EFI34053">
        <property type="protein sequence ID" value="EFI34053"/>
        <property type="gene ID" value="Dthio_PD1392"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="307" mass="33973" checksum="52C3288DF25B5A91" modified="2010-08-10" version="1">MTRWIRPSTRAFFTEASRDADDSLSSRLHGYIYGRWPYFYISLATGRHPLSGPAGKVLRSVRVLLRANDSRARARARIKFAHGYHGKVLPVQEAKRLVQINKSVDLGNLEQVIPYDRARRIVLKNPGHIVALKCPCRASSPHPCEPLQVCLIIGEPFAGFILEHHPGKARRITSDEACRILEQEHARGHVQHAFFKDAMLGRFYAICNCCSCCCGAMQAHRNGVPMLASSGYAADADQELCIKCGECAQACPFQAIAMSREGPVVSQDLCMGCGVCVSRCPVQGLKLKRQKDKSPPLEVNSLLHGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6STQ5</accession>
    <name>D6STQ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="9">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="9">TH kinase</shortName>
            <shortName evidence="9">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiM</name>
        <name evidence="11" type="ORF">Dthio_PD1410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Thz kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871420.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1410"/>
    <dbReference type="EnsemblBacteria" id="EFI34071">
        <property type="protein sequence ID" value="EFI34071"/>
        <property type="gene ID" value="Dthio_PD1410"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1717689at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="267" mass="28318" checksum="08628F45505B1DC7" modified="2010-08-10" version="1">MITSEKVWERLEEIREKRPLVLNLTNIVVTSITANALLALGASPAMTRSEHEVEELTSLGSALVLNMGTPCMNQVQAMRLGASRAVKLGVPVVLDPVGAGASKLRVDAPMEFLKKGWVSILRGNASEIMALGGSGDKPRGVDSLHGSALALEAARELSSRYECVVCVSGEKDLVVSRDKVLTVNNGHPMMTRVTGMGCCSTCLVAAFSAVEKDFLQAAAMGMAVMGLAGERAVQEASGPGSLQTGFLDILYAMDKEMLQGMHIKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6STQ9</accession>
    <name>D6STQ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871424.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1414"/>
    <dbReference type="EnsemblBacteria" id="EFI34075">
        <property type="protein sequence ID" value="EFI34075"/>
        <property type="gene ID" value="Dthio_PD1414"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="6"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="291"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="713" mass="79806" checksum="8A487E0E0DA80861" modified="2010-08-10" version="1">MIDYEKSLNPAQLEAVTTTRGPVLVIAGAGSGKTRTIVYRLAYLVEQGVPPESILLLTFTRKAASQMLRRAGELLNREMGMVSGGTFHGFSYMILKKFAPALGFPQGFSVMDAADAEELFKGVRNELKVGQGDKSFPRNRTILSYLSKARNKEVSLQSIIESEAAHLHDYLEDFKKLEEAYLLEKQKQALLDFDDLLFFLERLLTDNPEVLEYVRSVYGYVMVDEYQDTNLVQARLARLIASDQGNIMVVGDDAQSIYGFRGADVGNILDFPGTFPGARVIKLEQNYRSTQPVLSLTNCILSSMGQKYEKNLFSTRTDGARPELITPSSDMAQAGAVLSRVEELSSRYPLHDIAVLFRAAYHAYPLEVELNKASIGYQKFGGMKFSEAAHIKDVLSLMRMVQDPPEILAWKRGLGLLKGVGPKTAQRLYQAYCTSLTSGDGSELKKFETKNEQFAGLMELLRRQKNLPASPSSFLTEVLDFYRPFLEEKHMEDLPRRLSGLEQLEQITSAYNHLEAFLADMVLENSDPVGMQAREDALVLSTIHSAKGLEWSAVLLIDLVEERFPSRRAMQDPDDMDEEQRLLYVACTRARDYLGLFVPQSIYQRSTGFNQRVWPSPFVREIDTSLYSKVKEQAGIFSGEKKNPQGDGPLPGEVSPRSSRRSQTSAVPAGGYCRHKVFGRGKVVQALPPNKYKVNFPGVGLKTISGDYLNFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STR9</accession>
    <name>D6STR9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871434.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1425"/>
    <dbReference type="EnsemblBacteria" id="EFI34085">
        <property type="protein sequence ID" value="EFI34085"/>
        <property type="gene ID" value="Dthio_PD1425"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1927145at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="208" mass="24272" checksum="C64F66D379B31DF4" modified="2010-08-10" version="1">MLPDGVTTRFVQGQLRLFGLNELHPKTKNEVVEWARKNRQELQQARFNELLHLTGAHISRRSGKITLVFDPPLAGPDHDQKRWQLAGELEEMFRKMPELAISKSTRSDPAAPHKEVKKKITPEMMRSQKASRPWILPRLPELKTYGWTPRMLFRVGRFKYPLGNWGPAWCDNWVRPDVKVKIDPDGAIRWSWTEKTGRTVTQAKRPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STS5</accession>
    <name>D6STS5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871440.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1431"/>
    <dbReference type="EnsemblBacteria" id="EFI34091">
        <property type="protein sequence ID" value="EFI34091"/>
        <property type="gene ID" value="Dthio_PD1431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="9615" checksum="0780A6980D7E076E" modified="2010-08-10" version="1">MVYFIAKLDTVGPGLLQAKSAGAISELPFASRKDARRAAIAYAGEEALANGSLVILEQEGEGGVSVWEAFEDGPGEEDGPWAEGWEDRCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6STX3</accession>
    <name>D6STX3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HicB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871488.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1481"/>
    <dbReference type="EnsemblBacteria" id="EFI34139">
        <property type="protein sequence ID" value="EFI34139"/>
        <property type="gene ID" value="Dthio_PD1481"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="109" mass="12234" checksum="6460AE089666A541" modified="2010-08-10" version="1">MKLMQYRGYYGSIEASVEDAVLHGKLEFINALVTYEGETVKEIRRAFEDAVDDYLAYCSERGYEPEIPCKGAFNVRVGHKTHLKAALAAREKGISLNEFVRRSIEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU03</accession>
    <name>D6SU03_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG/DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871786.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0409"/>
    <dbReference type="EnsemblBacteria" id="EFI33094">
        <property type="protein sequence ID" value="EFI33094"/>
        <property type="gene ID" value="Dthio_PD0409"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9645" checksum="66AEB8C120279DC7" modified="2010-08-10" version="1">MKDQYDFSKGKRGAVTPASGNKVRITIRLDSDIVDWFRSRVEEKGGGNYQTMLNQALRSYIDQQGQPLEDVLRRVLREELNSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU70</accession>
    <name>D6SU70_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871546.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0157"/>
    <dbReference type="EnsemblBacteria" id="EFI32850">
        <property type="protein sequence ID" value="EFI32850"/>
        <property type="gene ID" value="Dthio_PD0157"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="509293at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0536">Nodulation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="4">
        <location>
            <begin position="402"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="612" mass="68389" checksum="0E43E3EF286BB8D5" modified="2010-08-10" version="1">MIILGISALYHDSAAAIIDEHGIIAAVQEERFSRKKHDFSIPVNSIEYCLNAANIKADELDAVIYYENPVLSLDRIIKTAFDTGHSALEQSVSQVSQMYSNKLWLDSQLRSLFGCLGKNDELLYAEHHMAHAASAFFPSPFSEAAIVTIDGVGEWATTTIGCGHGNIVELFQEVRFPHSIGLLYSAFTMYCGFKVNSGEYKLMGLAPYGNPTYCEIIKDNLIDIKDDGSFRLNVDYIGYLTGDTMINDNFRNLFGGPERKQESEISSKYMDIAASIQKVTEEVVFKLVHHARTLIDSPNLVMAGGVALNCVANGKVLGQSGFDNMWIQPASGDAGGALGAAYLAAFQYFNADRIFEKPDSMKGCLLGPSYTTDEIVRFLDINGAVYHSFTDEHSLNRTLALELEKGKIAGIFRGRMEYGPRALGNRSVIGDPRKKDIQSTMNLKIKHRESFRPFAPSVLAEDTADYFDLSTESPYMLIVAPVSESRRHAFDIQSVKESQNSILAIVNTPRSDIPAVTHVDFSARVHTVDYVRNPRYHALLKEFKEITGCSVLVNTSFNVRGEPIVCTPEDAFRCFMRTDMDILVLENTLLFKYEQNRIQTYYYDEEIAYELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUD4</accession>
    <name>D6SUD4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871607.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0228"/>
    <dbReference type="EnsemblBacteria" id="EFI32914">
        <property type="protein sequence ID" value="EFI32914"/>
        <property type="gene ID" value="Dthio_PD0228"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2022157at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="106" mass="12305" checksum="C7530420A415376D" modified="2010-08-10" version="1">MDENKEEYISRLKAKMDELNKDLDKLTDEAAQAEGGLKEEYQQQMLDLRKKLKELEGKLAAVQDSGESGWEDLKQGMEKSWATWKKSFSRAKEEFEKAYREGPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUJ1</accession>
    <name>D6SUJ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871664.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0285"/>
    <dbReference type="EnsemblBacteria" id="EFI32971">
        <property type="protein sequence ID" value="EFI32971"/>
        <property type="gene ID" value="Dthio_PD0285"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1033671at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="371" mass="40469" checksum="355A666A98103CBF" modified="2010-08-10" version="1">MYTTLFSPLEIAGKTLKNRITMAPLYLGYAGEGGTVSPLLLEHYRLMASGGVSMITVENATVDHPAGSGSNRTIRADTDENLPGLEKLAATIKNEGALACLQINHAGRFAGAQEAVAPSEVNTFGRTPRALTLEEIEEIRNSFVRAAQRAFKAGFDMVELHGGTGYLLAQFASPRTNKRKDYYGGSLEKRMRFPLEVMQAVREAAGNKPVGYRFLADEWLPDGLTLEESGPLASRLSDAGAAYLSVMGGTYESFSMPEVIKATKKPGYMADLAGEIRDQVRVPVIAAGRIALGHVAEEVLSSGRADLVGLARVLWADPEWPEKVRQDREDDLVICDPGCRDVCMQLVMQGKPAFCPNWSPQKSRRLKDLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUK4</accession>
    <name>D6SUK4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871677.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0298"/>
    <dbReference type="EnsemblBacteria" id="EFI32984">
        <property type="protein sequence ID" value="EFI32984"/>
        <property type="gene ID" value="Dthio_PD0298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016410">
        <property type="entry name" value="Phage_imm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14373">
        <property type="entry name" value="Imm_superinfect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087964" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="118" mass="12612" checksum="C2B8CE097A282821" modified="2010-08-10" version="1">MKPIKIAGLGVILVLLSVSLAYADGRPDPIVGIEGDLSHVISSAMWFVQNMVLFGIGAAIYLAPTIIAMIRSHNKLPQIAALNVFLGIIVVGWIGALIWSFTGNVHPQNFLDRFGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUP5</accession>
    <name>D6SUP5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="9" type="ORF">Dthio_PD0339</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0339"/>
    <dbReference type="EnsemblBacteria" id="EFI33025">
        <property type="protein sequence ID" value="EFI33025"/>
        <property type="gene ID" value="Dthio_PD0339"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="197" mass="22625" checksum="FF26C79537C0597A" modified="2010-08-10" version="1">MLLCKRDNISRLVINFMEETAQKPRWYIIHTYSGYEQRVERTIKEMMRTGQDKGLIEEIVVPTEQVVELVKGQKKTSTRKFFPGYVLVKMVFNDESWHLIQSIPKVTGFIGSKNKPSPITDAEADKILSTVQSRKEQPRPKFHFARGDEIRVVDGPFANFNGVVEDVNYDKGKLKVSVSIFGRQTPVELDFVQVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV12</accession>
    <name>D6SV12_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871860.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0060"/>
    <dbReference type="EnsemblBacteria" id="EFI32768">
        <property type="protein sequence ID" value="EFI32768"/>
        <property type="gene ID" value="Dthio_PD0060"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="196" mass="22328" checksum="409CFAEA3A6283A8" modified="2010-08-10" version="1">MANTNHPQKGSNITVEPIRSLEDIKSIKKLLSGNPRDHLLFTMGINNGLRIGDLLQLKVRDVQGVKPGDTIRVREQKTGKTNILVINKATHKALQTYLSQTLAEPENFLFKSQKGNAPLTVSYANRMIKDWCRQINLRGNYGTHTLRKTFGYIQRVHYGVGYELLCKRFNHSSPAVTMRYLGIEDKKVNNILMHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJW5</accession>
    <name>D6SJW5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869290.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3624"/>
    <dbReference type="EnsemblBacteria" id="EFI36168">
        <property type="protein sequence ID" value="EFI36168"/>
        <property type="gene ID" value="Dthio_PD3624"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2001883at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="7835" checksum="FFC395510DAE68BE" modified="2010-08-10" version="1">MYRDREQARRTECPFAKNGFLAAPSEAELGPEAKMCSAEDCMMWRETREFEGRNIHPVGWCGLAGEPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK14</accession>
    <name>D6SK14_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869339.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3674"/>
    <dbReference type="EnsemblBacteria" id="EFI36217">
        <property type="protein sequence ID" value="EFI36217"/>
        <property type="gene ID" value="Dthio_PD3674"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="34"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="27994" checksum="BA9DB5C892A5987D" modified="2010-08-10" version="1">MATYRIHPLVMGTKRFDKSMMTYQHGAGTPYIIPIYAWYLEGGDRNILVDTGEMSPIISEDRRQDLGGTIYTFEEGLARVGLQPNDIDAVIHTHLHNDHCENDAECVNAEIFVRPEEIESAHNPHPLDYRYLDDYILDAEENGQIRTVEKDMELFPGIYVMHTPAHTPGGMSVFVQTSQGRAAITGFCVIEENFDPPKEIRAMEMEVIPPGTLINSYQAYDIMLRVRDSADIILPLHEPRFADGKAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK68</accession>
    <name>D6SK68_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869390.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3734"/>
    <dbReference type="EnsemblBacteria" id="EFI36271">
        <property type="protein sequence ID" value="EFI36271"/>
        <property type="gene ID" value="Dthio_PD3734"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1813824at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="93" mass="10471" checksum="F0B206C520A01AB0" modified="2010-08-10" version="1">MMVGTLYINIRLHGITSLKAKRKISSSLKQKLKNKFNLAVAEIGSENSLDHLEIAMVTLANDKLRVEEILNKALQMVEAMSTDDLQEVKIEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK78</accession>
    <name>D6SK78_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3744</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3744"/>
    <dbReference type="EnsemblBacteria" id="EFI36281">
        <property type="protein sequence ID" value="EFI36281"/>
        <property type="gene ID" value="Dthio_PD3744"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1718114at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="120"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="271"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI36281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="289" mass="32180" checksum="9FD1B80152571FDF" modified="2010-08-10" version="1">MKKQNDFENFFHAGIMDHLEALIRLALQEDGQDLTSMAVFSPEDKCLAVIKARQKTLVAGLPLVQIILNKIAGESRPEFMVQEGDLVDPNTPVVNIRGGTCKILRAERIILNFMARLSGIANLTRAYIQKIQDTDVKLLDTRKTTPGHRYLEKYAVRLGGGMNHRMDLEEMLMLKDNHIDQAGSIEKAVQILRNTYQPCPPVEVECRSVDDVREAVRAGSDRIMLDNMGMDEIRFSLKITRQAGVESEISGGVNLDNIRDLALLGPTYISVGALTHSAVAADFSMNMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK80</accession>
    <name>D6SK80_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869402.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3746"/>
    <dbReference type="EnsemblBacteria" id="EFI36283">
        <property type="protein sequence ID" value="EFI36283"/>
        <property type="gene ID" value="Dthio_PD3746"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="368" mass="41077" checksum="A162499D3FBC6242" modified="2010-08-10" version="1">MSKLYDVIIIGCGPAGATAALLLAAKGMDVAVLDKKSFPRFKLCAGMLTQKTLDQCSLFYPELAHELKKRDIIRHVSSQYAISTGKKRLYTGSSKYSYVLVDRESYDQLWHEKVRETGASVYREQIVRVDIPESRVTAKNGRVFRGRFILGADGGSSRVRKTLALEKVVRPPWSKGSALALETFVSRQQAGFPDFPELFTGIVPDGYAWSFPGASRQRLGICSAVVKDGRELRKIMLDLLAGQGVHLDEKEIRGHVLPYGDYEKTPGFQNILLLGDAAGMADPLLGEGIYYAHATGGLAARAVEECWSRNDRTADVYSSLLSDIIRDMRIKWFMRKAGLGLLPLLQLRSLRPCLDFILPRLEHMIHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK96</accession>
    <name>D6SK96_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869418.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3762"/>
    <dbReference type="EnsemblBacteria" id="EFI36299">
        <property type="protein sequence ID" value="EFI36299"/>
        <property type="gene ID" value="Dthio_PD3762"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034AGG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2175325at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="81" mass="9272" checksum="BDB6F22C52F23CA3" modified="2010-08-10" version="1">MSTQMIVRIDPGLKDHAGQLARQEGKNLSELVRELLIKYINERDMSAHIDDLWDRIGRQLSSQAALSDIEKAVQDVREKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKA2</accession>
    <name>D6SKA2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869424.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3769"/>
    <dbReference type="EnsemblBacteria" id="EFI36305">
        <property type="protein sequence ID" value="EFI36305"/>
        <property type="gene ID" value="Dthio_PD3769"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1947977at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022452">
        <property type="entry name" value="MqsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032758">
        <property type="entry name" value="MqsA/HigA-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15731">
        <property type="entry name" value="MqsA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03830">
        <property type="entry name" value="CxxCG_CxxCG_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="19431" checksum="F401706B98FAB8CF" modified="2010-08-10" version="1">MSFANGMSCPVCGKGYIQRHLKREEFEYKGQAKIIDDYPLLICDACEEEFVSAEDSRLFDKELTAFQRKVDGLLTPDEIRSIREKLGYNQTSFARLLKVGEKNFARYETGVSPQSRYLDWLMRILNDYPETIKTITGNRDSNPDKNISVQYPNNLSDGFWFFRKSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKD6</accession>
    <name>D6SKD6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD3807</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869458.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3807"/>
    <dbReference type="EnsemblBacteria" id="EFI36339">
        <property type="protein sequence ID" value="EFI36339"/>
        <property type="gene ID" value="Dthio_PD3807"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="142"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="389"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="704"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="948"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI36339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1065" mass="119371" checksum="A674A14C565E5F84" modified="2010-08-10" version="1">MPQDNTSKGLSELTPEQCQELFTNAPIGVFTTTSDGHLLSTNPFLAQMHGYDTPEELIDSITDIPSQLYADPEDRSKLQQQLATRGQVQNFECRFLRRDGSVFWASINIRAVRDATGSFTHYQGFVSDITAHKQTEEALRKSEEKYRTVFENTGTASCILEKDGTISLVNARFAQLAGYHPEQIENKKTWMEFVVPEDLESMRHQHNLRRKDRKKALTEYEFRFVDKDSNVKNIYLYIDMIPGTDKSVASLLDITDLKRSEQEMKAQKRLLEGIINGVSDVLAIQYPDLSIERYNQTGYDLLGMSLDEVKGRKCFELIGRLQECEECATRKALKSRKAEQIEKFVPELGIYLECRSNPILDEKGNVVQLIEQLRDITEYKQKAEALRESEQKLRSLFSAMTEAVVLHELVFDSRGEAIDYRIIDCNQAFTKMTGISKAEAVGKLATEVYGTDTPPYWQEFSQVAITGTPLDFSTYYQPLNKHLRISVVSPEKNKFATIITDITELKKAEETIRLNEKRLQTLLDLNNMKDASVTELTHFAMEAAVSLTGSSMGYVAFPSEDETVLNMFAWSSKAMQECAIKDKHVEFKVCDTGLWGEAIRQRRAIITNDYSTSSPLKKGMPEGHVHVTRHMNVPIFDQDRIVIVAGAANKPTAYSDDDVRQLELLMSGLWTILCRKRAEQEREQLQARLLQAQKMESIGIMAGGVAHDFNNLLQTMSGNIEFLLQDKSADHPDISRLQAISRSIARSASLVQQLLLAGRKAKFQKVQVDLNEELQEVFQMLERVVPKMIALELHLDPYIEPIAADPVQIEQVLLNLANNAVDAMPQGGRLAFETNSVVLDEAFVKLHPGVTPGNYVLLSVTDTGCGMDRETLHHIFDPFFTTKETGKGNGLGLATAYGIINAHGGYIQCYSEPGQGTTFKIFFPVQEADALQPDESAPAENAPGGRETILVVDDEPEIRELTREALESLGYSARVASSGEEALDIYKQQGENVDLVLLDLNMPGMGGRKCLQELLHLDPRVRVLIASGYASNGLDVLNIGSRGYLGKPYQINELAAKIREVLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKF7</accession>
    <name>D6SKF7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869479.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3828"/>
    <dbReference type="EnsemblBacteria" id="EFI36360">
        <property type="protein sequence ID" value="EFI36360"/>
        <property type="gene ID" value="Dthio_PD3828"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="708486at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007516">
        <property type="entry name" value="Co_F420_Hydgase/DH_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045220">
        <property type="entry name" value="FRHB/FDHB/HCAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007525">
        <property type="entry name" value="FrhB_FdhB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31332">
        <property type="entry name" value="PTHR31332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04432">
        <property type="entry name" value="FrhB_FdhB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04422">
        <property type="entry name" value="FrhB_FdhB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="432" mass="48676" checksum="ACF17037CFAA9BC8" modified="2010-08-10" version="1">MSSFQTLVEEVHQNDRCHMCGGCVTFCTAINYGALEIGEDGLPRYKDQNSCLECGICYMLCPEVEELDVEINSLANWEEPAGKIISSSILRARDRQVLDRATDGGAVTAILLHLMESGRIDGAVVSRNKGLFNREPMLARTSEQILECCGSYFDVSHGTYHYGTQYSTYSPSVQALGDVKTQGFRSIAFVGTPCQVRTLRKMQALGVVPADAIYCVLGLFCTGNFEFDDNSRKRLEKTGEFSWKDVQKINVTDKVYIYMQDGSIHALPLDELDFIKRRACNYCHDYSAELADLSFGGVGSDDGWTTVLTRSPLGMEILRYAERNSLERLGMQDPDTQDQRSALDAEIQDLKSRMQHLQYRRLENPETTAHGYQEMLERLKYLQKQKQKLQPAKQRPEQHALNSCLEVVLEKCRQKKGQIPQSRSRTAPATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKJ1</accession>
    <name>D6SKJ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868336.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2610"/>
    <dbReference type="EnsemblBacteria" id="EFI35202">
        <property type="protein sequence ID" value="EFI35202"/>
        <property type="gene ID" value="Dthio_PD2610"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50333DW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2079377at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="110" mass="12610" checksum="7844790DB754B091" modified="2010-08-10" version="1">MHVMHVDERKILDYLLNKERSRGKAAFFMAMGFEASQWEVFARALKQQAFSGTLSSTVESPYGTRYTVDGPIETPNKRTQMPNIRTVWIKESAIAEWRLVTAYPLKGDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKN7</accession>
    <name>D6SKN7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868381.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2659"/>
    <dbReference type="EnsemblBacteria" id="EFI35248">
        <property type="protein sequence ID" value="EFI35248"/>
        <property type="gene ID" value="Dthio_PD2659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="148" mass="16664" checksum="32C6AA47A2E73E6D" modified="2010-08-10" version="1">MTVVLAAFSLWAVRSFFPEHDARLAVDHDMDPGEIDIPGEKAIETLTRGIKLVEDPPERRHAETVDFSFLPRPDPVPEKHIPLIVELIFIGKEKKFAAINGQIYEEGEVIRGGKKILSINPDGVLVRSPSTERRLLPWHQTRAVGLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKQ2</accession>
    <name>D6SKQ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868396.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2674"/>
    <dbReference type="EnsemblBacteria" id="EFI35263">
        <property type="protein sequence ID" value="EFI35263"/>
        <property type="gene ID" value="Dthio_PD2674"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="225"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="435" mass="50503" checksum="ACA212A3916E629B" modified="2010-08-10" version="1">MKQVLQEIILDFQELQLETGTPRRLKLTTLPGKASVCIGVRRCGKSTYLFQIMEQLKRDGVQAENILYLNFFDDRLHALQHMGLEVILEAYFGLYPEKKNSRTVYCFFDEVQALPGWEPFVDRLMRTEKCQVYLTGSSARMLSKEIATQMRGRAISWELFPFSFREFLDAKGIKSSGPHSAKKRLTIRKAFEDYWETGGFPEVTGLEKYLRLKIHQEYFQAVLFRDVVERHNISHPRAVTDLAHRLMDNIASLHTVNRLTGYLKSLGHKSPKAAVSDYLEWFEDAFFFFSVRIFDPSLSRSKTNPRKIYCIDHSLVTSVASGILINSGHLLENMIFTALRRLTSDIWYYKTAKGLEVDFIIHLQDRSRRLIQVCETLSHKDTRTRELRALDQAMEELGLDSGTLVTRDHDEDMELNGRRIEIISAWRFLLSLPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL94</accession>
    <name>D6SL94_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868587.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2875"/>
    <dbReference type="EnsemblBacteria" id="EFI35455">
        <property type="protein sequence ID" value="EFI35455"/>
        <property type="gene ID" value="Dthio_PD2875"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="45"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="382" mass="42553" checksum="E501AEA0EFED69FB" modified="2010-08-10" version="1">MYCVRAETIYTGRQVVQDACLVFDDSGIVGVFPEVYGEIIRECRVITPAFIDPHSHIGMVRAGEPRAEAESNDRQDPILVMADALDSLQMDDQALQEAVEAGVLYSCILPGSGNIIGGKSAVIRNYASDSTRAFVDRAGLKAALGYNPMSTTSWNGSRPTTRMGALAMLRNRLDEVLVKEKRRQAADEEKKKEIILSAEEETLLKVLKGELVLRVHVHKIDDIAALLRLVDEFSLRVSVEHAMGVHHGDIFKELSRRGIPVVYGPVDAFAYKVELKHENWRNLKHLLDSGVEYGLMTDHPVTPARQLFLQTRWFLRLGLSRQEVVEILTRKNAALLGLDDRLGTLEKGKWASFICWKDDPFDLAGYPEAVYGEGSAVYTAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLA0</accession>
    <name>D6SLA0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868593.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2881"/>
    <dbReference type="EnsemblBacteria" id="EFI35461">
        <property type="protein sequence ID" value="EFI35461"/>
        <property type="gene ID" value="Dthio_PD2881"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031GZT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2048811at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021558">
        <property type="entry name" value="MazE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11455">
        <property type="entry name" value="DUF3018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8262" checksum="AD63BD0A55236C5C" modified="2010-08-10" version="1">MTVPVKERVRKHREGLRSAGMRPIQIWIPDTREEGFGEECRRQSLLVANDPQEKEVLSWIEDVSDREGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLB5</accession>
    <name>D6SLB5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868608.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2897"/>
    <dbReference type="EnsemblBacteria" id="EFI35476">
        <property type="protein sequence ID" value="EFI35476"/>
        <property type="gene ID" value="Dthio_PD2897"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="233"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="619"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="864"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="425"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="589"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117034" checksum="BD58D9B5759338CA" modified="2010-08-10" version="1">MISSSQTFLKADMLKSTGITEKNGPRSILIVDDEPEQRIIIKKILTSAGYRVLEAESGVECTELIRRQQPDLVLLDVKLGDESGLDICRQIKTDSDIADTHIMFLSGVKTSPQEQARGLRAGADGYIVKPVNKEEFLARIEALMRVVHTEERLKESQHRLVSAQRIAKVGDFIWDVQTGNITWSDSLYELLQYDRSQRIDYETVKNHVHHPDDVQDIADWLKKSLASGEKDLPPMEYRVFRKDGQILYVRTTGVIYYQNNKASRVFATVQDVTQQIMARVRLSEINECLLSLGPDFNENIEKLTALCGRILGATCALYNRLEGDLLCSRGQWQTPPDYHPEDTPQGHICFDVIQKGSNSHVVVTSLQETSYADTDPNVTKYGLKTYIGQAVRQGDSYVGSICAVYQTDIIPSEDDLHVLRLIASAISAEENRKRAEEALRESEKKYRQLFENSPISLWEQDFSEVKKRLDELKAQGIKDLEAYLKQRPELVWEMAGLVKVIDVNQGTLNLYKANFKDELLAGISRIFGKESYADFLQGLLLIASGETSFSFEREHVTLAGQNLKTQLYWSVIPGYEVDYSRVLVCIVDITELVNIQEELIQAKEQAEAANQAKSEFLANMSHELRTPFNGIMGMMQVLQNTDLDDEQQEFVNLSIQSSERFARLLSDILELSNIEAGKMIICPAHFSLQELLESLSGLFSAEGHQKGLALEFLMDSNVPAEVIGDATRVKQVMFTLVGNALKFTEQGSVQVQLTPLSATKGGDVRVQFSVFDTGIGIPEDRLSDLFNPFVQVDGSYTRKYQGAGLGLSLVKRLVDLMNGNISVESEVDRGTTVHVVLPFALPPVDHLESAIAAANQQDSKKHLDILLAEDDNLNQLFMKKMLEKQGHNVVLANNGQEAVDLFQEQNFDCILMDIQMPGMTGVEATQRIRSMEHGAWGPSETPVCDREPFGLFHGAGMEHGAEVRGQETEDGDQTSEMGKRIPDFLNTSIPQSPNPRIPIIAVTAHTQPGDRERFLEAGMDDYIGKPVNHEDFQRVFSKFFGQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLH1</accession>
    <name>D6SLH1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2956"/>
    <dbReference type="EnsemblBacteria" id="EFI35532">
        <property type="protein sequence ID" value="EFI35532"/>
        <property type="gene ID" value="Dthio_PD2956"/>
    </dbReference>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="634" mass="70990" checksum="D151CD285E395D4E" modified="2010-08-10" version="1">MIKELKNSFVPVIFMMSLMLLLFSVNAAAEKNETVTRWMGGFYLDLPANALPLMERDELLYILGIGPMGIPQDISVEELKKMARGGVGLGHEPPPRGHAEAGYRGFYKDFQEMLPEMSTDEPEFETSYITLAGEEAFLVKAMFTMQENAPDGTFDSHQTWAVAVNKIPDAEGNYRMLFLMANDHLLNQHPGLIESILKSADADSPPPLELDSYFTYKEIGEREFNDFQPVMLPGRYAALVDRSRYVVRIYDHGGEVQHEWSFEEEATRDNLAVRRIDARAESDGHLLILIGRNNENPDELLRFSPAGELDDSFSLDLSVSGKDERLYARYIISSNQKGLLMGAESRSGDANGPFLVKFSRDMQVQTKLNMDGTYPFAIFPDGSIFAVYEDDAEGFFVNLDHEGRRMEAWGLYGSGTPPVYVDEFNMPDFEHLEVDNAGNIYAQERYSIWIYDRSGRLLQVVPTSNQAGNRNEMAVGPEGHVMLVNTGRRPGPMTSGPAVFMYKNIEPAEVRAIEMPAPAPQEPEEVESSETVMGDDTAEEVEVQEGFSRELLALVSQEGLTVRAFRAFEDVPPGFNSLAMHLRGQGKDLLGADIDQLEKWINSADSLRMSAEHQKTLKKLHEQMNKVMQAAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLI9</accession>
    <name>D6SLI9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD2974</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2974"/>
    <dbReference type="EnsemblBacteria" id="EFI35550">
        <property type="protein sequence ID" value="EFI35550"/>
        <property type="gene ID" value="Dthio_PD2974"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17202">
        <property type="entry name" value="sCache_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="392"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="465"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="524"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI35550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="797" mass="86654" checksum="86CF81703E10EF4D" modified="2010-08-10" version="1">MRFTIFWKILAILGSTIVLVSAAIFLTTNHFVTQSLDEQALDTLDNYRQAVDMEIEEISSNAAFVNSVVVENPDVAEAIKQGDSEFLHDYGNELTQAQHIGFIAFTNAEGDVVARGHIEEKGDNIQHHYIVQQVLRGDSITGIEHGEHISLSIRSGEPVKKDGEVVGAVVMGESFETHAFVDRIEQKLGVDATIFEDDTRISTSIRDEAGDRLVGTQMEDPEVIRTVIQDNEIFWATNPVQGVMYDTIYWPIEDVQGEIVGMYFLGQPRDVIEGIQASVLNSILAVTAVVGALMLAVGAFFARRLGGSVSRAAGFASMIARGDMDKPLEIKSRDETGQLAESLNEVRDNVTRLIKDTEHMAESIRHGDIRAVLPVEQYEGAYSKLAKDINNASEIVAGYLEVVPSPIVTMDKDFNILWMNKTGVDLFGGNRSDVEGEKCYDMFRTQDCQTEACACTQAMKTGSERTNETRAYPGDMQLDISYTGRPIKDNQGRVVGAIEFVTDLTQVKASQRKMQEVAQRAASVSDSVSSASDELSAQVEQASRGTEEQTNRIGETATSMEEMNATVLEVARNASGAAEQTDMARAKAQEGAGVVKQSVEAINEVQEQSKAMKDNLASLGKQSEEIGKVMTVIDDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMNATKEVEKTVTSIQESTKSNMDSMDQSVQAVEKATQLANSSGQALQEIVSLAQEAADQVRSIATASEEQSSASEEVNKSMEDVNRIARETADAMNQSAQAVSDLAKQAGELQKIIEDLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLK6</accession>
    <name>D6SLK6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SapC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868699.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2993"/>
    <dbReference type="EnsemblBacteria" id="EFI35567">
        <property type="protein sequence ID" value="EFI35567"/>
        <property type="gene ID" value="Dthio_PD2993"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1512520at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010836">
        <property type="entry name" value="SapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07277">
        <property type="entry name" value="SapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="237" mass="26876" checksum="92BD6EC3C8058164" modified="2010-08-10" version="1">MQPLSTTKHAGKYFHQPKNYQHAKNRTTVPLVISELPRAVPAFPVCFTISRNKYILSALMGLKPEQNLFVTQEGKWRTSYIPAYLRGHPFYLAESQEGKQVVCVDENSGLITDVGAEPMFGEDGKPTPKMQQIIDFMEKIARERAVTDRACAVLNELGMIEPWEGYGGLYRVSEAKLKDLSGEAFVQLRDTGGLKVMYGQLYSLTQMARLKKLAEEQAEPDLENMEELEIDWDKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLX9</accession>
    <name>D6SLX9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate reductase</fullName>
            <ecNumber evidence="6">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868819.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3119"/>
    <dbReference type="EnsemblBacteria" id="EFI35690">
        <property type="protein sequence ID" value="EFI35690"/>
        <property type="gene ID" value="Dthio_PD3119"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="687" mass="76476" checksum="123262F599D3BCC5" modified="2010-08-10" version="1">MIIHTVCRFCSACCPVEARVESGRLISAQRKSFLPPAERINCPRLMRAPEIVYSRKRLSSPLIREGKKGAARFRDAGWDEALDLVASKFLQHRDVSGPESIAWLRGMAADWGAPWDYAQRLMNAFGSPNSIGNGSVCHVAREMAHFYTYGAMTMPGIKDSSCVLVWGKNDRNTMPGAFEALLHARQNGAGLIVVDPVRTPAAAMADIHLQVKPAHDGMLAMAMMHEIINSDLHNKNFIRDYTLGFDALARAVQNYPPHEVAPFAGLDARDIIKAARMYARSSPACIVDGNGLDMQLHTFQATRAVAMLRAITGNLDIAGGDIIPQPPRVHNIQLRDRLSPDTYPVTRDYSLFGSFHPNWGLHAQSCLVDAMLDQTPYPVNMVVVQSGNPLATMADSTRVQKAFESLDFMVVIDPFFTRTAELANVILPASMCFEKTQLNRASLRTSPVILQDRAIEPLPGTRPDWKIIFALAEKLGLKKEFPWEDVQEAIDFQLEPSGITVEELRNSPQGIRDGEQVFEKYRSKGFNTPSGKVEFFSDRLEQNGHDPVPYQHGRRENPISFSSHAGHALVGMSGERENRFTHTQFHHVDKLLKTGEKPTVDLHEQDAGSLGITAGEMVRVHTPRGSIKMQAGVTDRVRPGHVIIAWGWGEVHQDYNLNLLTDDHHRDPVTSTPSNRSFMCSLEKLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM75</accession>
    <name>D6SM75_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5981 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868915.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3221"/>
    <dbReference type="EnsemblBacteria" id="EFI35786">
        <property type="protein sequence ID" value="EFI35786"/>
        <property type="gene ID" value="Dthio_PD3221"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1284428at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022026">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12225">
        <property type="entry name" value="DUF5981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5981" evidence="1">
        <location>
            <begin position="111"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="215" mass="22796" checksum="647E1C26677FE813" modified="2010-08-10" version="1">MIVAEVKPMAEIQETIKKYGKVLITGCGSCVTVCLSGGAQQVEVLASSLRTAAKAQGQQLELGEETQVRQCDPMFIEQIKDKAAGYEAILSMGCGAGVQTMAETLGNIPVYPALDTVFFGGADGKGGFVETCAACGQCILSRTGGVCPVARCAKSLADGPCGGAQEGNCEVDKDTRCAWQLIYVRMMRLGQLHILKEINPPKAARVHPARLKREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMA4</accession>
    <name>D6SMA4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868944.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3250"/>
    <dbReference type="EnsemblBacteria" id="EFI35815">
        <property type="protein sequence ID" value="EFI35815"/>
        <property type="gene ID" value="Dthio_PD3250"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="762291at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="254" mass="27318" checksum="74E4E6C9E6CF2FC3" modified="2010-08-10" version="1">MLLKDKKAVIFGVANNKSIAYGIAEQFKEHGASLAFNYVGESLKKRVAPISEELGGEFIFDCDVTDDEQIRAAAETVREKWGQVDILVHSVAFAHRDDLQGRFIDTSREGFRLAMDVSAYSLPAICHAFEPLMNPGSSVMTMTYYGSVKTVTNYNVMGVAKAALEASMRYLAVDLGPKGVRVNAISAGPIKTLASSGISGFKTILSTIEEKAPLQRNVTQTDVGKSAVYLASDLSTGTTGEVLFVDSGYNIVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMD7</accession>
    <name>D6SMD7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868977.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3286"/>
    <dbReference type="EnsemblBacteria" id="EFI35848">
        <property type="protein sequence ID" value="EFI35848"/>
        <property type="gene ID" value="Dthio_PD3286"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="119"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="222" mass="25276" checksum="607F5FE08AD76CB4" modified="2010-08-10" version="1">MTHLTQELDRLNMKVMQMVVQTEQALSKTVNAFSRMDADLAQEVVDHDKQINELEVLIDQLCLRLLALEQPVARDLRFILGAMRLSKDLERIGDESANISDATIFLSLHPPLDFYDQIQIMGQKAYDMLQEAIIAFSSPDTERAINVCRMDFEVDEINSKVLKLSIEHMSQNSQAVEQCVQSINIARRFERVADLATNIAETTMFIVQGTSIKHSCLFDDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMG0</accession>
    <name>D6SMG0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869000.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3310"/>
    <dbReference type="EnsemblBacteria" id="EFI35871">
        <property type="protein sequence ID" value="EFI35871"/>
        <property type="gene ID" value="Dthio_PD3310"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1759683at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024513">
        <property type="entry name" value="DUF3334"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11813">
        <property type="entry name" value="DUF3334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="215" mass="23992" checksum="91EB525DF6D3FE3B" modified="2010-08-10" version="1">MPKQQVKSTDEILTILCEAIKSTLDATTGTSLHYSSTFIRTNKTCLRPEIGCFVLFEGGFAGLVAMNFSADAALEIYTKYNLNMGMPEEDLAKHHTSNEVADAMGELMNQCVGKFRQMLKANVGVGVNQTQPKMVALNQAMKLTLEADLERPQYRRVEFKTEGQKFFYLEITLEKVEFIYKAPDNVSVSSQGEESSSSDSDNNESPEEFMKKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMI5</accession>
    <name>D6SMI5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14 15">UvrABC system protein B</fullName>
            <shortName evidence="14">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uvrB</name>
        <name evidence="20" type="ORF">Dthio_PD3335</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 14 15">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869025.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3335"/>
    <dbReference type="EnsemblBacteria" id="EFI35896">
        <property type="protein sequence ID" value="EFI35896"/>
        <property type="gene ID" value="Dthio_PD3335"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 14 15" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 14 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14 15" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14 15" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="430"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="626"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="14">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFI35896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="664" mass="76476" checksum="F9F3B481F767BA63" modified="2010-08-10" version="1">MTAFNLVSEYTPQGDQVEAIEHLVQNLDQGLDHQVLLGVTGSGKTFTMANVIARSNRPALVMAPNKTLAAQLYNEFRLLFPENAVEYFVSYYDYYQPEAYLPRTDTYIEKDSSINDDIDKLRHAATHALLTRRDVLIVASVSCIYGLGSPEYYSKMIIPLEEGQTMDMDELMARLVEVQYERNDYDFHRGTFRVRGDVLEIIPAYRMEQALRIEFFGDTVESLFETDPLTGEIKSRLKKTVIYPGSHYVSDQDNLQRAMNDIRDELRHRLNWFQEQNMLVEAQRLEQRTQLDLEMIQEMGYCNGIENYSRHLDGRRQGQPPACLLDYFPDDYLLFIDESHITIPQVGGMYNGDLSRKKTLVDFGFRLPSALDNRPLSFDEFQERMGQTVYVSATPGPWEMDKSQGVLAEQIIRPTGLVDPEIEVRPTHGQMDDLLNECLQRQENDQRVLVTTLTKRMAEDLTDYLQERGVRSKYLHSDIDTLERVAIIQALRAGEFYVLVGINLLREGLDIPEVSLVSILDADKEGFLRSTRSLIQTFGRAARNVDARVIMYADRVTDSMRRAMDETERRRSKQKEFNLEHGIVPASIVKAGPNTLYEMHNQPEPEQMGLAAEEISRYGADPQKLEKEIKSLERKMRKLAQDLEFEEAARVRDRIQDLKNALMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMM7</accession>
    <name>D6SMM7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Starch synthase</fullName>
            <ecNumber evidence="4">2.4.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869066.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3380"/>
    <dbReference type="EnsemblBacteria" id="EFI35938">
        <property type="protein sequence ID" value="EFI35938"/>
        <property type="gene ID" value="Dthio_PD3380"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="3">
        <location>
            <begin position="2"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="511" mass="57723" checksum="66A3953394E3A36C" modified="2010-08-10" version="1">MKVLYIAAECKPLSKVGGVGDVAGELPPALKEQGVDLEIVTPCYGQTLQKNPGLNSLTPTHEYSLTFHGVREDISILHTEFRGVPANLLKSPAYFETDYTLEPDKAPFNHPLLFKNDYSTPYVYSREIPYFDDALRFSFFCRACLPLIQEKDPDIVHINDWVMGYLPGWMKIMNMPQKTVLTIHNIGYQGNIHRQAIQDWDMQEIDRHQDTMGLFTDPRREWNSVNALRLAMEMSHAINTVSPTYKKEITMPQDQSRFFQGGNGLDEVAARLDSQGRLHGILNGFEYSFSPDDAGFESMIREKSRMKAALGNNFPDPEGLLLGFVGRAVEQKFRLLREEVQGKSVLEHILDMPGVNVAVLATGEPEYESFLQSLSDRPNLYAVIAFDAQKAGQISLGSDVFLMPSLFEPCGITQMQSMSHATPPLVRWTGGLADTVRPHNDPAGTGFGFDGSSRREILTNQLEAVNQARQVYTQNPLHFRALQYTGYYERFLWANSALEYIEKLYQPVMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMX2</accession>
    <name>D6SMX2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3475"/>
    <dbReference type="EnsemblBacteria" id="EFI36033">
        <property type="protein sequence ID" value="EFI36033"/>
        <property type="gene ID" value="Dthio_PD3475"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="162" mass="18514" checksum="44034CBE2F7B9252" modified="2010-08-10" version="1">MSDTCHTFYSVTFLQLVTALSMLLLSEKKKGEKRQEEILSLVQSALDGLSARIAPVDEKGTIVLVNKQWRNFAKENQLTPDMVSEGVNYFDVCRQAEGEWSEGAMDFARGLQRILNREEELFTLEYPCPAPDKEFWFRAGVTPLPDENRNWAVVAHQDITEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMZ6</accession>
    <name>D6SMZ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36057">
        <property type="protein sequence ID" value="EFI36057"/>
        <property type="gene ID" value="Dthio_PD3501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="245" mass="27740" checksum="D75A963AE7F611C9" modified="2010-08-10" version="1">MEPGRRDFKAAVVVFGERSQALAQYIEEKTQGLLKRFSHLNPDSEWLQGEGTPVIAVLGGDSNRIGLNSLFGYECVFLAGALDAEYVEKCRDYLQRQDFEKGPFVFLLPVSEPDPDNIYKKETLIKKENGDCLDLQLAADFVHDFCAFLMFPNEISADAREYYGLMEGKSIKLSYSRIYPEDPGAKLRLQPGVKDLFFVLYVDSQQQVLATASEILQTFESKGIENIWFSDVCMSSVNKIMCLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN62</accession>
    <name>D6SN62_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZnF_CHCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0002</name>
        <name evidence="6" type="ORF">Dthio_PD0083</name>
        <name evidence="7" type="ORF">Dthio_PD0091</name>
        <name evidence="8" type="ORF">Dthio_PD0452</name>
        <name evidence="9" type="ORF">Dthio_PD0484</name>
        <name evidence="10" type="ORF">Dthio_PD1537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869518.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0002"/>
    <dbReference type="EnsemblBacteria" id="EFI32720">
        <property type="protein sequence ID" value="EFI32720"/>
        <property type="gene ID" value="Dthio_PD0002"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32786">
        <property type="protein sequence ID" value="EFI32786"/>
        <property type="gene ID" value="Dthio_PD0083"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32793">
        <property type="protein sequence ID" value="EFI32793"/>
        <property type="gene ID" value="Dthio_PD0091"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33134">
        <property type="protein sequence ID" value="EFI33134"/>
        <property type="gene ID" value="Dthio_PD0452"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33161">
        <property type="protein sequence ID" value="EFI33161"/>
        <property type="gene ID" value="Dthio_PD0484"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34188">
        <property type="protein sequence ID" value="EFI34188"/>
        <property type="gene ID" value="Dthio_PD1537"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1963592at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="4">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI32720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI32786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11621" checksum="9E893B80F0DDF642" modified="2010-08-10" version="1">MAQRYSREELQRLRNKVLVNDVIVHILDMPSKVRDGYLRFLCPLCSEFLTACNPRTNLARCFRCERNFNPIDLVMVVKGLNFREAVEFLQDMEQRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNB4</accession>
    <name>D6SNB4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869568.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34240">
        <property type="protein sequence ID" value="EFI34240"/>
        <property type="gene ID" value="Dthio_PD1591"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZIMV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1955971at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="142" mass="16671" checksum="6B07E76AF204B033" modified="2010-08-10" version="1">MIRNVWSVLCRDIITDQETNSVTYVRCIEEGAAAEVPIKIGPIFLGTLWEKDSQEQESIRFRVALELPDKSLKPVLQTRSMTLERPRHRLHFRINSLDITSFGMHYIIAEYNQDEKWHRTVRIPVLIRQIQKKTEPETGKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNG9</accession>
    <name>D6SNG9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type IV-A pilus assembly ATPase PilB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869623.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1646"/>
    <dbReference type="EnsemblBacteria" id="EFI34295">
        <property type="protein sequence ID" value="EFI34295"/>
        <property type="gene ID" value="Dthio_PD1646"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013374">
        <property type="entry name" value="ATPase_typ4_pilus-assembl_PilB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02538">
        <property type="entry name" value="type_IV_pilB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="5">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="559" mass="62032" checksum="7923425E4BF6ABA8" modified="2010-08-10" version="1">MVDELISWAGLESEQVHKARSVQGEKRIDFPRACLAAGVISEEQYRDFMAAHLGLPVVDPSRMQVCRETLGQLDRSAWARYQAVPFFVHQDRLYLACFEPDNITALDDIQFMTGMQALPHLATLSSIQLVLDRLADKDSGRMDDILAQMEAEEGPDAGEGPEKEEASTMEAASQAPVVKMVNLIIQEAIRKKASDIHIEPYEKDFRVRLRLDGMLTEVMRPPIRMKNALISRLKIMSHLNIAEKRLPQDGRIKVRSQEGTPIEFRVSILPTLFGEKVVMRILDKSMLQVDMHDLGLEDHSLKVFEEAIKRPYGMVLVTGPTGSGKTTTLYSAIMELNQEGVNISTAEDPVEFSLHGVNQVQVQETVGLNFASVLRSFLRQDPDVILVGEIRDLETAEIAVKAALTGHLVLATLHTNDAPSTLTRLLNMGVDSFLVASSINAIMSQRLVRRLCPSCRVPETDQELLKAMGMSSQESGQDGIFRAAGCEECNNTGYKGRTGVYEVMPVTHQIQEMVLAGKSDLDLRRAAVEEGMITMRKSGLIKMSQGMTSAQEVLRVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNJ5</accession>
    <name>D6SNJ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">Dthio_PD1672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869649.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1672"/>
    <dbReference type="EnsemblBacteria" id="EFI34321">
        <property type="protein sequence ID" value="EFI34321"/>
        <property type="gene ID" value="Dthio_PD1672"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="15"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="332" mass="38563" checksum="88ABB0DD23277DD7" modified="2010-08-10" version="1">MRQGGEKRVVSGMRPTGPLHLGHYFGVLQNWVDFQENYTCYYFVADWHALTSEYAEPRKIKPFVAELVKDWIASGLDPEKCVLFQQSLIKEHAELNLLLSMITPLGWLERNPTYKEIRQELINKDLNTHGFLGYPVLQAADILIYRPDFVPVGHDQLPHLELTREIARRFNHLYGDFLPEPQAKLTESAKLPGLDGRKMSKSYGNCIYLGEEMETIRPKVMSMLTDTSRMRKADPGDPEVCNLYPYHRLMTPEETCREIRENCTQAKWGCVDCKKLLLTHLEEFLAPIQERRRRMDDHPELLSEILNTGNTQARHEAARTMELIREKLGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNQ0</accession>
    <name>D6SNQ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869704.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1728"/>
    <dbReference type="EnsemblBacteria" id="EFI34376">
        <property type="protein sequence ID" value="EFI34376"/>
        <property type="gene ID" value="Dthio_PD1728"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="100" mass="11451" checksum="F9470A05773C57BE" modified="2010-08-10" version="1">MFELKNHVSASQIKDFCHRHHIRKMSVFGSALHGELKPGSDIDILVEFHKEHVPGLLDLAGMEMELSEMTGLKVDLRTPAELSRYFREDVMQKARVEYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNX4</accession>
    <name>D6SNX4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase FolE2</fullName>
            <ecNumber evidence="2">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folE2</name>
        <name evidence="3" type="ORF">Dthio_PD1809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Converts GTP to 7,8-dihydroneopterin triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase IV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869772.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1809"/>
    <dbReference type="EnsemblBacteria" id="EFI34450">
        <property type="protein sequence ID" value="EFI34450"/>
        <property type="gene ID" value="Dthio_PD1809"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="757842at2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01527_B">
        <property type="entry name" value="GTP_cyclohydrol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022838">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="May be catalytically important" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="29357" checksum="989A572A63FD573C" modified="2010-08-10" version="1">MQDVQSGMPEFPLPIDRVGVKNLKLPLLVQDRLHGQQHTVADVDLCVDLPGEFKGTHMSRFLESLSHWSKVLTYESIKELLAEIIHRLEAQKALLRFDFPYFYSRRTPVSGHEFLMDYKSFLAGEFSMGEIRMTQGVEVPVMTVCPCSLAISKQGAHSQRAYVKIKCGYKGLLWLEELIDTGMSAGSSPVYPLLKREDEKYVTDEAFANPTFVEDVVRCVAFSLSRHPRIIWYEVEVESFESIHNHSAYATITGRGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNZ4</accession>
    <name>D6SNZ4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869792.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1829"/>
    <dbReference type="EnsemblBacteria" id="EFI34470">
        <property type="protein sequence ID" value="EFI34470"/>
        <property type="gene ID" value="Dthio_PD1829"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="318986at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="YcaO" evidence="3">
        <location>
            <begin position="76"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="575" mass="64744" checksum="C4C134AF027E0A1A" modified="2010-08-10" version="1">MIKIGSSPKGYTQEADKALTPQETVEKVTGALNQHGQAILKKIKRIDTGRLGIPVYFSYYGVRARDMGVPKRQQMGKGVSPAQAQCSALMELIERYSFFSFVSSDENFIRLSWKKARSRWGDQLIPTAEIIKSVQEDISRQQAEEVLDLIQWRFTPALNVYEARQEYVPLDWFKKLSEFNGSSAGNTLEESILQGACELVERHVSAIVDKEHLQIPTINQESIKSPVLRDLLDRFSRHNIKVWLKDMSLGYPVPTVGALAYDPGTFPGLSEIVFTAGTATSPEMAAIRALTEVAQLAGDFHTGSNYEASGLPKFTTLKETGWLTRGPVTDISSLPDISRPDMGRELMELSRGLKLMGYSLYSVSTMHPDLEIPANYSFVPGFLFRERTPRASIGMFAGRILAEEEDPIAAAGKLEQLKKIYPDASFLPFYQGMNLLRQEEHQQAAKYFARAESLQPDSESRGLSAFYSAYALSGLHRWPETIEHLNRAIELDPLVKEYFNLRGVAYFKQKDYEHAIDDFQKALQLDSGSVMDMFNLAVCYKELGRRNAAAEMLQKVLTIDPGLEKARRFLEEMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNZ5</accession>
    <name>D6SNZ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfur relay protein, TusE/DsrC/DsvC family</fullName>
            <ecNumber evidence="5">1.8.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DsrC/TusE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.99.3" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869793.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1830"/>
    <dbReference type="EnsemblBacteria" id="EFI34471">
        <property type="protein sequence ID" value="EFI34471"/>
        <property type="gene ID" value="Dthio_PD1830"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1840461at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018551">
        <property type="term" value="F:hydrogensulfite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042072">
        <property type="entry name" value="DsrC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025526">
        <property type="entry name" value="DsrC-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043163">
        <property type="entry name" value="DsrC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007453">
        <property type="entry name" value="DsrC/TusE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37010">
        <property type="entry name" value="PTHR37010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04358">
        <property type="entry name" value="DsrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006223">
        <property type="entry name" value="DsrC_TusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69721">
        <property type="entry name" value="SSF69721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03342">
        <property type="entry name" value="dsrC_tusE_dsvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006223-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="11936" checksum="BD3D62F889E18316" modified="2010-08-10" version="1">MATVEFKGKTFEVDEDGFLQKFEDWSPEWVDYVKESEGIKELTDEHQKVIDFLQDYYKKNGIAPMVRILSKVTGFKLKHIYELFPSGPGKGACKMAGLPKPTGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP61</accession>
    <name>D6SP61_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">Dthio_PD1909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869857.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1909"/>
    <dbReference type="EnsemblBacteria" id="EFI34537">
        <property type="protein sequence ID" value="EFI34537"/>
        <property type="gene ID" value="Dthio_PD1909"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1083409at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023515053" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023515052" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="182"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="42160" checksum="E8F89684D7F9AD6D" modified="2010-08-10" version="1">MQDLPLGFDLAAVRAGFKYKDRPDLALIFSRTPARAAGVFTTNAFQAAPVLVARENLDRSDLMRAVLVNAGQANACTGEEGLADCRRTLDLLAGHLDISAGEILPASTGVIGVRMPMPTWEKSLPGLVENLGKCTGEQAAMAIMTTDTFPKTAAREIELDQGRVRFWGMTKGAGMICPDMATMLAFVLTDLQVDGALWQEMLAGAMEQSFNAITVDGDTSTNDCVLALAGGGSRAGLHSSRDRDIAAKALEDVCRDLAYQIVKDAEGGTKVMHIRVTGAADSLDARKAARAVGNSSLVKTAMFGCDPNWGRIVAALGRSGAVFDPDKVRLSLAGLEIFSKGRPVDMDIDEVFAPLLSSRDIQVDIDLGRGQGEYFLMASDLTDEYIRINSDYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP65</accession>
    <name>D6SP65_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869861.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1913"/>
    <dbReference type="EnsemblBacteria" id="EFI34541">
        <property type="protein sequence ID" value="EFI34541"/>
        <property type="gene ID" value="Dthio_PD1913"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50343K9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1889601at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="102" mass="12123" checksum="A22D95D0CB1137E3" modified="2010-08-10" version="1">MEKVLKKLADELNSLDEASLISLWDKYYERVQNFSPSREWEEDILILSMIQSVRWKNQLFNQCLSQQSGIPSKHEEKKDSLRPVRRDKVKKSAKVLSFKPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP79</accession>
    <name>D6SP79_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HSDR_N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869875.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1927"/>
    <dbReference type="EnsemblBacteria" id="EFI34555">
        <property type="protein sequence ID" value="EFI34555"/>
        <property type="gene ID" value="Dthio_PD1927"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031H6C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1445436at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSDR_N_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="190" mass="21509" checksum="169C392F5C05C712" modified="2010-08-10" version="1">MHEVKFDQVIQDYLTGKDLQMTTYEDIRQALARILVEEKGYPVQNIKPRYKLPLGLDDIDYTINLDFLVTIDEQPAMILGFCPGAVSTYITQYVSAARIFPGGPVPFVLVTDSTDAALVRVKDKKEICRGYHCIPTWQHLQEIFKECPPCTFTTERQLKEKRVAHAMFALSDGYCSSSCEITSDKSQADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP87</accession>
    <name>D6SP87_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1935"/>
    <dbReference type="EnsemblBacteria" id="EFI34563">
        <property type="protein sequence ID" value="EFI34563"/>
        <property type="gene ID" value="Dthio_PD1935"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933101at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="203" mass="23287" checksum="DCA9B122BEC49D40" modified="2010-08-10" version="1">MDTRIVDSHPAAARLETLGIRYLFKPESSALQPQQEPVPGADTRPPSCYVHPHSNDATGFQTDPLLEPLYRPSYSVWTYLELYEDLFCGFNTPRARLLTAIQNSMGWDACSFTYWPVTRNFSDKTVPDKDFFYSAMDRINPVYIFCFGAAAFNILFPRERFAYGKWVTGHFSIMALPSIDALMPDNRLLKNFTWRMINSLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPB3</accession>
    <name>D6SPB3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1961"/>
    <dbReference type="EnsemblBacteria" id="EFI34589">
        <property type="protein sequence ID" value="EFI34589"/>
        <property type="gene ID" value="Dthio_PD1961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="58" mass="6825" checksum="F399C357B4F094CF" modified="2010-08-10" version="1">MSLQGEIKPCKDIFFPRQIFLNVPRQLNYASGVTERVAVITLGRDWRFKNKITLYVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPD2</accession>
    <name>D6SPD2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1980"/>
    <dbReference type="EnsemblBacteria" id="EFI34608">
        <property type="protein sequence ID" value="EFI34608"/>
        <property type="gene ID" value="Dthio_PD1980"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="169" mass="19175" checksum="74E0F351AE345AC4" modified="2010-08-10" version="1">MVENFEKVQSQAQIKRTSLLARKIWQEHYTPIIGIEQVEYMLKNFQSPEAISDQLQNGAVYYLVVSAGEDSGYLALEPDPEMASAKLSKIYVLKDKRRCGLGRKTLEFAEMLCRDMGVKDLWLTVNRHNHAAIAFYRQEGFTAAETVVQDIGGGFVMDDYKMVKSLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPH9</accession>
    <name>D6SPH9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869975.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34655">
        <property type="protein sequence ID" value="EFI34655"/>
        <property type="gene ID" value="Dthio_PD2027"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503357W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034266at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="176" mass="20411" checksum="F6BFCD546A1F92A3" modified="2010-08-10" version="1">MSTDSQKVIYWLDRKRSIIEVGGAWDRFALENDASKAFSRQVKGSSVWKYIRDDSTRMWLDTLLQLAEITGDAVERPYRCDSPDTRRYMQMKIIPEKPGVLRVEHRVVSTEKRNRTVYFKTSDQMSRNMVSRCSICGRVKSKDQWQEPDQGTQEKPLNLTVVYTVCPTCSSSLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPM5</accession>
    <name>D6SPM5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870021.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34701">
        <property type="protein sequence ID" value="EFI34701"/>
        <property type="gene ID" value="Dthio_PD2073"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HGU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2090208at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="81" mass="9131" checksum="C187497852707B9E" modified="2010-08-10" version="1">MRTTLAIDNDVLEKARALAARRKIPFKTVINEALRAGLREVEKPALQQDYTTMPQPMGLKQGRNLDNIQELLAQVEGEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPV7</accession>
    <name>D6SPV7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870099.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2160"/>
    <dbReference type="EnsemblBacteria" id="EFI34783">
        <property type="protein sequence ID" value="EFI34783"/>
        <property type="gene ID" value="Dthio_PD2160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11358" checksum="DAB0968271078DA7" modified="2010-08-10" version="1">MTDAEKIIDQIEQKIGQSEGHGEELKKEIQSDVRAVDDYIDRRIEQLGNQIRSEVAQSMEAYREEMVELNGCLRMYIIYTWAGIASVVIFYLVRSVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ37</accession>
    <name>D6SQ37_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870177.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2254"/>
    <dbReference type="EnsemblBacteria" id="EFI34863">
        <property type="protein sequence ID" value="EFI34863"/>
        <property type="gene ID" value="Dthio_PD2254"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="118" mass="13132" checksum="8B1A0BB06AC721B6" modified="2010-08-10" version="1">MNVGDIYWVNLAPTLGDEIKKTRPVVILNGGHSKHLKLAIVVPVTTWNPNWEGNPFFVCLEPSVSNALQKKSAIDCYQLRSLSHQRFLEKLGQINSAELDAVKKAVALILDIDPEHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ79</accession>
    <name>D6SQ79_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870219.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2296"/>
    <dbReference type="EnsemblBacteria" id="EFI34905">
        <property type="protein sequence ID" value="EFI34905"/>
        <property type="gene ID" value="Dthio_PD2296"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="321"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="434" mass="48319" checksum="C83D396065377DAA" modified="2010-08-10" version="1">MALKFKKGFWLALVLILAVGAGYVYINYVDKEEPVIGIEPEVSYTNAEKPFEIQVHDPGLGLKHVEVKVIQNGEVKKSVDEEIEPGINDLEASLELPDLDQGEFELQVRAVDRSIVNWGRGNESLASRKMVFDSIPPSVSLVSTTHNLNQGGAGLVIYSLSKEVEKTGVQLGEYFFPAYQKPDGNYYCLFSFAYDADPQGDTPRVMAQDKAGNRQVTGFNYHVNARDFRQAELNISDGFLRSQMPQFESKFPDENDPLEIFLRVNRELREQNRDRVQEISARTSPDFRVEGPLKRKPSAFMAGFADHRSYYYEGEKIDRQVHLGVDLASTAQAPVPAAERGEVVFTGDLGIYGQTVILDHGLGLQTLYAHLSSIDVSEGQDVARGEDIGRTGTTGLAVGDHLHFEVLVSGVPVNPSEWWDGTWLENNIFSKISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ82</accession>
    <name>D6SQ82_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="14" type="ORF">Dthio_PD2299</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870222.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2299"/>
    <dbReference type="EnsemblBacteria" id="EFI34908">
        <property type="protein sequence ID" value="EFI34908"/>
        <property type="gene ID" value="Dthio_PD2299"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1751990at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5014006522" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014006524" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="72"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="12882" checksum="C48A02BC3188519A" modified="2010-08-10" version="1">MPLRTFLQAKIHRATLTGACLDYEGSISICPELLEISGIIPFEQVDVYNLDNGERLTTYAIRGEPGEIRLNGAAAHKGSPGQKVIIAAYCLLDAREQKEHIPSVVLVDGANKAKGQQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ92</accession>
    <name>D6SQ92_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">Dthio_PD2309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870232.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2309"/>
    <dbReference type="EnsemblBacteria" id="EFI34918">
        <property type="protein sequence ID" value="EFI34918"/>
        <property type="gene ID" value="Dthio_PD2309"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="776861at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="8"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="228" mass="24902" checksum="2E43709F40EB7869" modified="2010-08-10" version="1">MSTGPVTITIDGPAGVGKTTLARGLARRLKIAYLDTGAMYRAAAWMLGPSAAEMQEEELAKRLDGMRFTLKGAGPDSCLLLEDRVIGEQVRTEEVGLLASSIAALKVVREYMKKSQQKMGRETSLVAEGRDMGTVVFPDASCKFFLQADAGVRAARRCRQLQEMGREADEQKILEQMRRRDVQDSERAIAPLVPAPDAVNIDTGSLTPEEILDRMAAIFADTGGRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQA1</accession>
    <name>D6SQA1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870241.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2318"/>
    <dbReference type="EnsemblBacteria" id="EFI34927">
        <property type="protein sequence ID" value="EFI34927"/>
        <property type="gene ID" value="Dthio_PD2318"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="7452" checksum="AF5D04D2B2C204A3" modified="2010-08-10" version="1">MPIYEYHCPDCNKVFEELVKGQPDRVTCPGCKQDVTSNRCMSAAASFSRRDSSALPGSAAAPSCGPASGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQB2</accession>
    <name>D6SQB2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870252.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2330"/>
    <dbReference type="EnsemblBacteria" id="EFI34938">
        <property type="protein sequence ID" value="EFI34938"/>
        <property type="gene ID" value="Dthio_PD2330"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1355243at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="261" mass="30366" checksum="4F371310A3BA0733" modified="2010-08-10" version="1">MDRQESLRILGLGPDADLESIKKAYRELAFELHPDLNPDDPEAGYKFHQVNTAYVTLRKQAREGWHDYAESGKKTRASRKEATRTYERHARSEAARESTESKRHYESSAQQAREGFFYRQEEVLRDILKDPFAKQVFEDIFKRLKRDKKDTHPAEIKKRRFKLEWGRINLDVDLSGGVFAGIKKWFSSQLDDEQTVYLSPVKLRPGSSIRINVERRWAGPPQVVSVNLPQDYVVGRPVRLKGLGRKIGPWKGDLYLRLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQH9</accession>
    <name>D6SQH9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2397"/>
    <dbReference type="EnsemblBacteria" id="EFI35005">
        <property type="protein sequence ID" value="EFI35005"/>
        <property type="gene ID" value="Dthio_PD2397"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="214" mass="23965" checksum="7F7A00708B33D679" modified="2010-08-10" version="1">MPFLFDLHVHSLISPCSMLPLEDILAEARLLNLDGVCITDHNTTQARHQIREGVQDDGLCVIVGQEYSSLDGHFLIFGPHEEFEPYLPAPEITRRVNRAGGVIIASHPYRAMQKVDEKLVSRGIISYAEGLNGRNSELENSLAQNWQEKHGISLTGGSDAHCLEELGRVGTLFTEPVRSREDLVKALKNRNFRPARNPNYKQLVHWLESYGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQJ1</accession>
    <name>D6SQJ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH/Ubiquinone/plastoquinone (Complex I)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870331.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2410"/>
    <dbReference type="EnsemblBacteria" id="EFI35017">
        <property type="protein sequence ID" value="EFI35017"/>
        <property type="gene ID" value="Dthio_PD2410"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="133"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="515" mass="55777" checksum="69A05ED4142AB0C5" modified="2010-08-10" version="1">MITQNAPALIPVLYLISSMLIPMIGYFRSGASFYIALLTSVAVFGVSIMGLQEVMANGSISYHLGGWMPPLGIELVLDPLSAFISVIITASALMVMIYAHSNVRQEIPGSSMGFYSLSMLFMGGLAGMAITGDFFNLFVFLEISALASYGLLAIGTRRGPVSAFRYLVLGTAGAIFYLMGVAFIIIATGSLNMADVAKILPYAEYQRPVIVGLVLILVGIIIKMGVFPIHHWLPDAYSDASSTATALIAPIGTKVAAYILIRVMTIYEFPPLLDVMTWMAGLSIVAGSILAIAQTNIKRMLAYSSVANIGYIVLGVTLANPLAFIGAMLHILNHALMKLVLFMSAGGMLHSVGSVSISRMRGFPTVMPWTALAFFIAALSMVGIPPTGGFFSKVYLIMGAIEAEAWIFVAIIILSTLLAFVYLFRMINIAFFRPYEKSDDKKVIQSEELVLETPVETKDESKKEFESMPRKEMGLLMLLPVLIGSVIIILVGIYNGWIIDNMITNAIPDILKLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQL0</accession>
    <name>D6SQL0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclease (SNase domain protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2430"/>
    <dbReference type="EnsemblBacteria" id="EFI35036">
        <property type="protein sequence ID" value="EFI35036"/>
        <property type="gene ID" value="Dthio_PD2430"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088158" evidence="1">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="221" mass="25452" checksum="C453ACE5E6C2C1EE" modified="2010-08-10" version="1">MRARWRACVYWLFIAILLPGLAQAGAQNREVRVAWVPDGDTLILEDREVVRIKGMDAPETAGNGRPDQYFAQEATERLEELIKDRVITLKTGQVPEDRYGRTLAHAYLPSGENIGLLLVREGLAFYYPHEDQDEKISRDLLRAQQRAIDESAGFWPEVLNQHPEVETWAGNKRSKRFHHPGCGYGQRISEHNREEFDTLREAFYAGYAPCRRCTPWPDADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQN0</accession>
    <name>D6SQN0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heme exporter protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CcmC/CycZ/HelC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870370.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2450"/>
    <dbReference type="EnsemblBacteria" id="EFI35056">
        <property type="protein sequence ID" value="EFI35056"/>
        <property type="gene ID" value="Dthio_PD2450"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003557">
        <property type="entry name" value="Cyt_c_biogenesis_CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01386">
        <property type="entry name" value="CCMCBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="9">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="228" mass="25616" checksum="0E77AA24A8A539D9" modified="2010-08-10" version="1">MKYSDTVSSLLVPLALAGGAAMALAQYFIWFYAPVEATMGLVQKIFYLHLPLAWWGLICFFTVFCASIAFLVRKSPVMDQLAVAAAEVGLLLSTLALATGSLWARVSWNTWWTWDPRLSTALIMWFIYAGYLVLRQSIEGQRKMRMVAAVLGVVAFLNVPLVFLSARMWRSIHPAVFASEGGGLEPEMMTTVVVCVIAMGLVTAALVLMRFRQKNLQERLWNLYMYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQN6</accession>
    <name>D6SQN6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="6" type="ORF">Dthio_PD2456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2456"/>
    <dbReference type="EnsemblBacteria" id="EFI35062">
        <property type="protein sequence ID" value="EFI35062"/>
        <property type="gene ID" value="Dthio_PD2456"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019820">
        <property type="entry name" value="Sec-indep_translocase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01218">
        <property type="entry name" value="TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="269" mass="31134" checksum="C633E705A9907408" modified="2010-08-10" version="1">MTTEHDQETTEEEMPEEEGMTFTEHLEELRYRLFRIIIAAFVGFLICYAFKERLFDILMQPLVKVLPEASSMIFTGLPEAFFTYLKVSLVAGVFLASPYIFYQIWRFVGPGMYETERKFIIPIAFISALFFVVGALFGYFVVFPIGFQFFVGFANEMIQPMPSLREYFSFAVKLLFAFGIAFELPLFIFFLARLGIVSSKGLRKQRKYAVLVIFLAAAFLTPPDIISQVLMSGPLILLYEVSIWVAYIWGRERKFRGKKEDDDQDDDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQV1</accession>
    <name>D6SQV1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870441.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2521"/>
    <dbReference type="EnsemblBacteria" id="EFI35127">
        <property type="protein sequence ID" value="EFI35127"/>
        <property type="gene ID" value="Dthio_PD2521"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="497565at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="553" mass="62782" checksum="7648BF4E1C91951F" modified="2010-08-10" version="1">MKMRTCVTPEGKFRYGVHHPSYQVCNLRQKDHHFCLGRLPDETMVHNQDNFPEGDLQVNGAFTVYEIPNAFSFRGSTFIDSGWAASRAKDPLSIRISPPGEVSLLKSLDSWAAKENMSSQSVQGLFQELPHSLLLALATTSTDPQDLVRLAHLSCDFIKDSQRAEPVGLAYSRREDGSPLPVIHDRDLFEAVGNNPFLPDIYKEIMLLRPGVQGRSEIVGDVCEGEQSTRVFEYLRRNSYIPWGHYASNMSHQEVRYRAADLSLKDMQGLRHLYYQRTYVRLARELGLEPAAGPMSPQEMEQLRQAILAQIEKKPEQVSFTSTLWGWNFGFDFAPTRYRLHGSHQQVHQQHAMVPQRVPQAEQGRLTGEEFQGFSAGDMIAETVKEYLEETGQDFFRDYIRCLRNNTRLDGGKGEESLVVHEDKHVLLFVPKAQVSQWELQLLPQEQVGSILEADDECRRSLDRAMLLALQILEGLGARMVTSIEYSGRFTSPGLQRLMYSFLPKLPWSPGSFSEAQHRFICGHYPEDFAAACRNQAAEILQDPGLFEPKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQW3</accession>
    <name>D6SQW3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870453.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2534"/>
    <dbReference type="EnsemblBacteria" id="EFI35139">
        <property type="protein sequence ID" value="EFI35139"/>
        <property type="gene ID" value="Dthio_PD2534"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="15873" checksum="107C27491CA78096" modified="2010-08-10" version="1">MNKTVVFGSDHAGLWLKRVLMDRLSNDRQTIDVGTEDDSSCDYPVYAGRLCEKVLELQCLGVLICGSGLGMSMTANRFRGIRAALCCNEYMARMARKHNNANVLCMGERVIGVDLAGSILDVFLETGFEGGRHAKRLDIIEEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQW8</accession>
    <name>D6SQW8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MJ0042 family finger-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870458.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2539"/>
    <dbReference type="EnsemblBacteria" id="EFI35144">
        <property type="protein sequence ID" value="EFI35144"/>
        <property type="gene ID" value="Dthio_PD2539"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1587529at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011723">
        <property type="entry name" value="Znf/thioredoxin_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13717">
        <property type="entry name" value="zinc_ribbon_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02098">
        <property type="entry name" value="MJ0042_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Znf/thioredoxin_put" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="135"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="310" mass="34145" checksum="8BFC90D92599B34B" modified="2010-08-10" version="1">MRITCPKCMFQQDVPDEKIPPHAKKATCPKCKEKFQFRDLEEPEEFTLEDEPAAEEEASSDSREHDFATYQDEKPAQEKSREEDQEESLWSKLEDLGGPAEEPQRDQAAPGESSASPWENLQQYGFFPGFFETVKRVMLAPGPFFRKMQPGGLGMPLAFFILVSVIQVLASFLWNMTGMFPAAAEHGAPGMGIGMVGAGSILILLVYPLFMVAWIFIASGVTHLFLMAFQAGRSGFEGTFRATAYGSAPMLLGVLPILGPFIGALWSLVVTVMGYRYIHGTTYPRVILALIAPIMIIVLLATMMMGGPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR10</accession>
    <name>D6SR10_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870500.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35186">
        <property type="protein sequence ID" value="EFI35186"/>
        <property type="gene ID" value="Dthio_PD2587"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZUYU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022148">
        <property type="entry name" value="CopG_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12441">
        <property type="entry name" value="CopG_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="81" mass="9658" checksum="99539ACE75857EC8" modified="2010-08-10" version="1">MQTDKNNKNVSIYEASEFWDEHDFGEFDDVEETYEIQFSLKKKKYVGIDQDLYDCIKNKARELQKPEEALINEWLSEKAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR82</accession>
    <name>D6SR82_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar hook-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870556.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0524"/>
    <dbReference type="EnsemblBacteria" id="EFI33198">
        <property type="protein sequence ID" value="EFI33198"/>
        <property type="gene ID" value="Dthio_PD0524"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1815809at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01005">
        <property type="entry name" value="FLGHOOKAP1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="653"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="701" mass="78356" checksum="D52204B27F524602" modified="2010-08-10" version="1">MSGIHALMNSGRTALFANQSAIQTTGNNIANVNTEGYRRREVRLEEAMALDTAPGQIGTGVNAKEVFRHFDSFIETQYNDKSSDREMWQTMHEQLSSLEALFNESREGRMNEALADFWKDWQELSKRPDDNNVRTALLGNTGNLTQAFRSMDQDLTKNREQMDEFISQDVDRVNDILEEIAEINKLINVREVPGKVNLNELRDKRDLLVRELAEKVDINYMDKGGGDVTIQTKAGHTLVEGSETYRLKFEDSKTFSDLKSDFDGQIKYNGDSGYEFTIQVTEDGEIGGDAKFKVSLDGGKNWLTDDQGNTREFSAEDYDNRVTLPVDDMEIWFDDYSNNALAEGDEFTIVPKSGLYWESNTSSDMNITPQVMGDGNLNERRLTGGSLAGYFNFRDHYAGKYSEKLDALAESLAWEVNRIHSNGAGLEHMKYAEGTYQVNNLEAALGTPNAGLPHGEKLQNGNFTVHFYDEDGEVESMSPKFPTQDEMGNDPEDWTGNFDPDKHGLDHVMRAINELDNISAEPVNNRLTISADDDYEFSFSDDSTGLLAGLGINTFFQGHDASSLAVNEKVRDNIAHINAGSVNGAGEANVGDNTTAKNIAELQDRKVDITTSFEGTTSQTIQEYYNSLSGNVGSDTSMTKFNADYNKSLTDDLDRRQQEKSGVNLDEEMSNLIKYQHSYQAAARMISTADQMMQTLLGLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRJ3</accession>
    <name>D6SRJ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870667.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0636"/>
    <dbReference type="EnsemblBacteria" id="EFI33309">
        <property type="protein sequence ID" value="EFI33309"/>
        <property type="gene ID" value="Dthio_PD0636"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023312">
        <property type="entry name" value="Put_nitroreductase_C_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="198" mass="22308" checksum="30BFD159E38DFF08" modified="2010-08-10" version="1">MNIYEMVARSRSYRRFYENYKVSMETLTSLVDLSRLTPSAANLQPLRYIISNDPVTNGSIFETLTWAAYLKDWPGPSEGERPSAYIVILGEKKHSKTAAWDMGIAAQTIMLGATEAGLGGCIVGSIKKEALSEALQVPDELEVLLVLALGKPKEMVLLETLKPGQDIKYWRDSRKVHHVPKRPLEEVLIKSFERQEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRP9</accession>
    <name>D6SRP9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870723.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0693"/>
    <dbReference type="EnsemblBacteria" id="EFI33365">
        <property type="protein sequence ID" value="EFI33365"/>
        <property type="gene ID" value="Dthio_PD0693"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033GV5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2087770at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="162" mass="18403" checksum="2A795AFD9A99E85E" modified="2010-08-10" version="1">MGIREKILVTMMVLALAYGAFELFYSPADPVEEKDPEQEVQEAQQFSQSMSQDLQEADITEAQKRILQAAARDWPGEIFHEFPDAELLEEETVQEETDFGPLRYSGYVQMGDQKIAIINAREYSRGEELKDEPARVVEITSEKVLLESLETGQQVPVPYEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRR1</accession>
    <name>D6SRR1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0707"/>
    <dbReference type="EnsemblBacteria" id="EFI33377">
        <property type="protein sequence ID" value="EFI33377"/>
        <property type="gene ID" value="Dthio_PD0707"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031B2K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="12227" checksum="4941FA125DB8CD00" modified="2010-08-10" version="1">MTTKMDDNLIARLVDSGNYQFRKHAAERAAERGIDPLDVKEAILNGKIIEHYPDDPRGYSFLVSGKSREIKYTHIVCGYQDGILWIITVYEPDPEDWHDPYQRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRY8</accession>
    <name>D6SRY8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870806.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0788"/>
    <dbReference type="EnsemblBacteria" id="EFI33454">
        <property type="protein sequence ID" value="EFI33454"/>
        <property type="gene ID" value="Dthio_PD0788"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2073672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="88" mass="10134" checksum="9B659A92EF422C16" modified="2010-08-10" version="1">MIFRSNDKSRWGGEYWKASLLGIHLVTCTFVGLLIGYFLDKWLGTEPWLLLAFLIFGIAAGFKNMYMEVKKIQESEDKKEKGEDEHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS25</accession>
    <name>D6SS25_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870843.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0825"/>
    <dbReference type="EnsemblBacteria" id="EFI33491">
        <property type="protein sequence ID" value="EFI33491"/>
        <property type="gene ID" value="Dthio_PD0825"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669228at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="153" mass="16440" checksum="914FB0AE1FC7DBD2" modified="2010-08-10" version="1">MHNHITVKIKFLPHSEPGENGLEYATSGSAGVDLKAWIQENEITLAPGQRHPFPAGVALEINEPSVAGFVFSRSGLGTKQGLVVSQGVGVIDPDYRGEIIVSLLNNSGEPKTVARGQRIAQLIFMPWFKARFEEVSELSRTSRGAGGFGHSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS35</accession>
    <name>D6SS35_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="5">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.7" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870853.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0835"/>
    <dbReference type="EnsemblBacteria" id="EFI33501">
        <property type="protein sequence ID" value="EFI33501"/>
        <property type="gene ID" value="Dthio_PD0835"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="4">
        <location>
            <begin position="15"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="267" mass="27917" checksum="1FF4AAE916BB904F" modified="2010-08-10" version="1">MTSPLPCTLTIAGSDPGGGAGIQADLKTFSMHRVYGLSVITALTAQNTTGVQGVFAPEPDFVALQLQSVLDDFPVRAAKTGMLFSADIISAVAGALKGADFPLVVDPVCVSQSGHKLLQDEAVQALKDKILPLSALITPNRPEAELLTGMHRISSRDDILKAIVRLQDMGAEGVLLKGGHFSPTHDITDWLGIRGQEPLAITKARVNTTSNHGTGCTLSAAIAANLALGMDMQAAVVKGRDYLQLALEKSFPLGRGHGPVNHLAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS40</accession>
    <name>D6SS40_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Riboflavin kinase</fullName>
                <ecNumber evidence="12">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">FMN adenylyltransferase</fullName>
                <ecNumber evidence="12">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="12">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD0840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ribF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="12"/>
    <dbReference type="EC" id="2.7.7.2" evidence="12"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870858.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0840"/>
    <dbReference type="EnsemblBacteria" id="EFI33506">
        <property type="protein sequence ID" value="EFI33506"/>
        <property type="gene ID" value="Dthio_PD0840"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 12" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="13">
        <location>
            <begin position="182"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="313" mass="35559" checksum="114657FB617AE845" modified="2010-08-10" version="1">MIVYDINALTDKIEGSALTIGNFDGVHVGHQQLIQQVRKRGRRMGLSSIVVTFDPHPLRVLVGKKTPPFITLNQHKLELMQELGVDYILCMTFNKDIASMEPEDFVYDFLVKKLRLRELIVGYDYVFGKNRRGNFHLLQQLGQKYGFSVDQFMPVMVDGAIVSSTRIRDLVESGRVWEVHPLLGRFYSVEGRVTTGRQRGGSLLGFPTANILLQDELFPSTGVYAVWAEISGSIHAAVANIGYNPTFGNDYLSVEVHIFDFHQDVYNHKVKVHFVQRLRSEKKFAGIEELKSQITLDCKLAREILKMPEAKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS60</accession>
    <name>D6SS60_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsF</name>
        <name evidence="7" type="ORF">Dthio_PD0860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870876.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0860"/>
    <dbReference type="EnsemblBacteria" id="EFI33526">
        <property type="protein sequence ID" value="EFI33526"/>
        <property type="gene ID" value="Dthio_PD0860"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="103" mass="11747" checksum="945DABD283C15C04" modified="2010-08-10" version="1">MQARYETLLLLNPELGSDGSNALLEKFSGVLEKNGGQVIKNDDWGLKTLAYPVKKQTRGRYIRMEYSLPAAQVSEFERNIRIADGVFKFLTVKLPQEKVQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSB9</accession>
    <name>D6SSB9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0920"/>
    <dbReference type="EnsemblBacteria" id="EFI33585">
        <property type="protein sequence ID" value="EFI33585"/>
        <property type="gene ID" value="Dthio_PD0920"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="14"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="351" mass="39127" checksum="8F5F4977C4F3C8AF" modified="2010-08-10" version="1">MSLTRLYFKHPEPDSSRQRLYPVFLPFSGCPFKCIYCSQEAQTGQQPTPHEVQVQRIHQDICTLFKKKPEPFSLGFFGGTFTALPAATQKLFLKTALELRRAGAVSHIRCSTRPDCIDQGRIRLLRDYGVDMVELGIQSFDSRVLSLSKRGYGGEEALDASMRIKQNSLELGIQLMPGLPGSDSASFARDLQATAEMQPAVVRLYPCLVLEDTLLARQWSRGEYRPWPLNTTLALVSNALLRMWLAGIPVIRTGLAPEGSLLPRIKAGPWHPALGAICRGRALGAYVTAMASRLGAGGPLQVLVPQRYISDFWGHGKENEKLYQRSKIFRKNVDTWDHELFMLAGCAPQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSI0</accession>
    <name>D6SSI0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0982"/>
    <dbReference type="EnsemblBacteria" id="EFI33646">
        <property type="protein sequence ID" value="EFI33646"/>
        <property type="gene ID" value="Dthio_PD0982"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="266"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="339"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="525"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="782" mass="89010" checksum="9BFD14629D3C85E7" modified="2010-08-10" version="1">MGYYMQKVLIVEDSESFALFLNKALIKNGYDVSAQVKTGEAALEHIRENDPDVILMDINLDGELDGIEAAELIRREKNIPVIYVTSQFNETVMHRAAQTLPYGYLCKPFNVHHLLGVLDIALRKRQVEIKLEKSRLQAEQELRLAKEQWEDTFDAVPDLIAVIDQELKIVRANKALSDRLNMDREEITGSHCYRVIDGTDSPPESCPFFDSEKTGRSHGEAYKASLGGYFDISCTSVKGLQGGKARVNVLRDITRRKEFEENLRRSEELYRRLAEDMPNLLCTFLPDSTLTYVNQAYCDFFQKNRHELVGQKWLDFLPREQRHAVREHLATIKPENPFVSYEHAVHRPDGSVSWQKWHDRGIFENQELLYIQSIGEDITDRKLASERLKENEKILKSVLESIHIAMIIMDLNTGKVLRTNEVAREYFYADDSAEADFEKKILPVILKGKNSLSSFASSLPVFNREVKINDVSGRLVPFLFYAFQSEFQGVESAVLIFYDISQRKNLEMQLAHSQKLEAVGELAAGIAHEINTPSQYVGDNTRFLQEAFTDLQQLLDLYLRLEKEVHAAGNDELLQKIRQARDEMDLDFILSEIPRAIEQSLQGLDRVSTIVQAMKRFSHPGGEEERVLFDLNEALTNIITISRNEWKYTSEVKTDFAEDLPQVAVYPNDLNQAFLNLIVNAAQAIQEKEQKSGGKGVIFISTRAVNGYAEVSIQDTGKGIPEYYQDRIFDQFFTTKPVGKGTGQGLAITYSIIVDRHGGQINLDSREGEGTTFTVRLPLTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSK5</accession>
    <name>D6SSK5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871020.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1007"/>
    <dbReference type="EnsemblBacteria" id="EFI33671">
        <property type="protein sequence ID" value="EFI33671"/>
        <property type="gene ID" value="Dthio_PD1007"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088187" evidence="4">
        <location>
            <begin position="27"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="251" mass="28812" checksum="DBC59A0955B20A77" modified="2010-08-10" version="1">MKNSRRKFIKIAGMAALGWSICPSLAGARSGPRQSENRLRADRWAMVIDSEKLNDEIMDKCIEACHKLHNVPEIPNDQNIKWIWKEPFYNLFSDQSHGYLKDKKSLPFLTLCNHCDNPPCVRVCPTQATFSRDDGIVLMDFHRCIGCRFCMAGCPYGSRSFNYYDPRKFLDDDELDHDYPTREMGVVEKCEFCAHLVDQGEMPACVEASEGAILFGDLNDPNSDVRKVLQERYSLLRKPKLGTDPQVYYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SST6</accession>
    <name>D6SST6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871101.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1091"/>
    <dbReference type="EnsemblBacteria" id="EFI33752">
        <property type="protein sequence ID" value="EFI33752"/>
        <property type="gene ID" value="Dthio_PD1091"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="129"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="305" mass="33238" checksum="57D758128FAD394F" modified="2010-08-10" version="1">MSENYRDLIKELDLLGLYRGDGSKKKEWELVLIAMGVDYHWEHGRIMVPASQAPRAVEEVRRYEEEEVELEKYEPDQAPRQQNAVSSLFVLSLLLLFFTVVYEGLGQSEWQFLPWLEQGSANASKIITGGEWWRTITALTLHGDPAHVLGNVIIGAPFVVAVCSRLGLGLGWLTILAAGALGNYINAIVMSPAHNSIGFSTAVFAAVGIMSIHSVKFSRLSMGNAFVLGLALLAMLGVGGENTDVGAHLFGLAAGFGLGILTLRAVDMQESLQRVDFLFGITAGLLVVESWLMALWGEGLMDVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSU3</accession>
    <name>D6SSU3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase accessory protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871108.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1098"/>
    <dbReference type="EnsemblBacteria" id="EFI33759">
        <property type="protein sequence ID" value="EFI33759"/>
        <property type="gene ID" value="Dthio_PD1098"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05390">
        <property type="entry name" value="HypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="31"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="220" mass="24623" checksum="1D2D9121E5095802" modified="2010-08-10" version="1">MQIKVLRNILEANDRISDQLREMFRQKGILVINLMSSPGAGKTSLLEKTLDQLRDEFSMAVIEGDLQTSNDAERIAATGAQVLQINTEGGCHLDSSMVQEAAGKMDLDQTDILFVENVGNLVCPAEFSVGEDFKVTILSVVEGDDKPEKYPLIFAESRVLLLNKTDLLPYVDFDMDKASGFARNINKNIEIFPLSARTGEGLEPWHEWLRKEVHRKKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSW3</accession>
    <name>D6SSW3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871128.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1118"/>
    <dbReference type="EnsemblBacteria" id="EFI33779">
        <property type="protein sequence ID" value="EFI33779"/>
        <property type="gene ID" value="Dthio_PD1118"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="283"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="384" mass="42384" checksum="B3C8716DCA9B5FC4" modified="2010-08-10" version="1">MAARSRKNKTTEIFALGNEAVVEGALIAGCTFYAGYPITPSTEIAEEMASRLPHLRGGAFIQMEDEIAGLGAVIGASLAGRKAMTATSGPGFSLMQEHIGYASITEVPLVLVNVMRAGPSTGMPTNPAQGDVQQARWGTHGDHPIIVLSASDVQECLRMTVTAFNYAEKYRTPVILLLDEITAHTREKISLPDPEDINIYTRLTPSMPPEWYMPYEDNMRGVAAMPPLGAGYRYHVTGLIHDDHGYPTSNPREVEHIMHRLFRKIDQFFYDIQMVDEIQCQDAEICIIAYGCVARSAELAVQQARERGVRAGLLKLKTLFPFPRPAVEKMLRQCSNVVVPEMNMGQMSREIKRVNATQSKIITLNRVDGQIITPGQILSKILKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST01</accession>
    <name>D6ST01_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside recognition domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1156"/>
    <dbReference type="EnsemblBacteria" id="EFI33817">
        <property type="protein sequence ID" value="EFI33817"/>
        <property type="gene ID" value="Dthio_PD1156"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1116727at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="329" mass="36641" checksum="2053C9364B0FFD6E" modified="2010-08-10" version="1">MKNLSAGILSSFAGIIREATVLFLRLLKIMVPVIILVKIITELDLLPYLADLLEPVMHLMGLPGSMGLVWATAILNNVYSAMIVFVSLPGSFELSVAQVTILSTAVLMAHALPIELRIAQKCGARLIFQALFRIICAIILGIILNFVYEWGGWLQGQNTVVWRPDPQPEGLMGWFAAQLRNLGVIYLIIMALVAVIRFLDYIQVTRILIWMLNPLFRLLGIGREAASITIVGLTMGLAYGGALIIREVRTRRIPQRDVFFSLTLMGIAHSLIEDTLLMLLLGADLSGILLARLVFSLVCVFLLYKIWAYLPSKYVHRYLHPLDASEVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST60</accession>
    <name>D6ST60_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ORF">Dthio_PD1215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871225.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1215"/>
    <dbReference type="EnsemblBacteria" id="EFI33876">
        <property type="protein sequence ID" value="EFI33876"/>
        <property type="gene ID" value="Dthio_PD1215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="329"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="PtIM" evidence="7">
        <location>
            <begin position="247"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="561" mass="63651" checksum="2E96DD2442B0D5D0" modified="2010-08-10" version="1">MSDEPNKIIYSMVKVSKHFDRKPVLKDISLSYFYGAKIGVLGMNGSGKSSLMRILAGVDQDFEGETILSPGYTVGYLEQEPLANETRTVREIVEEGAAEAVGLLKEFEEINARFAEPMSDDEMNDLIERQGQVQEKLDALDAWDLESRLDMAMDALRCPPPEMTLDKVSGGEKRRVALCRLLLQRPDILLLDEPTNHLDAETVAWLEHHLQQYPGTIIAVTHDRYFLDNVAGWILELDRGRGIPWKGNYSSWLDQKKERLRKEEKAESQRQKTLERELEWIKMSPRGRQSKSKARIGAYEQMLSQDYQKQHKDLEIFIPPGPRLGQKVIEANGLTKAYDDRLLINNLDFLIPPGGIVGIIGPNGAGKTTLFRLITGAEHPDSGSIELGQSVRLAHVDQHRDDLVPDKTVFEVISDGHDTIKMGGREINARAYLGRFNITGSDQQKKVGLLSGGERNRVQLARMLKQEANVLLLDEPTNDLDVNTMRALEEGLLNFAGCVLVISHDRWFLDRIATHIMAFEGDSRVVFFDGNFTEYEADRRKRLGKESDIPRRIRYRKLTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST63</accession>
    <name>D6ST63_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mammalian cell entry related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871228.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1218"/>
    <dbReference type="EnsemblBacteria" id="EFI33879">
        <property type="protein sequence ID" value="EFI33879"/>
        <property type="gene ID" value="Dthio_PD1218"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="374" mass="41978" checksum="633107C42B897CA5" modified="2010-08-10" version="1">MSTQPNYYTIGIFVSIGLALFLGALTVLGTGALWRETVTVETYLDESVQGIDRGSQVKMRGVTVGRVDEITFAGLKYPGSVDPGDRYVLLKISLELDEFGVPDQEAFERFLEQEIQKGLRIRLLPMGITGAAYLEMDYVDPARHPPLPVSWEPRNPYVPSAPGTFARLEETFESLGNTMAKIEEMDIQKTLNHLDHLIQSLDKSVQSFDLAGISARAEVFIEELRETNRKISGLIGPLEDPEEKRTDLHAVLKDSRQILQKVDKGLDRLQIDKEGGAADQIARTLDNLHQASKTLPETMDSIDVTAASLKESSKSVERLSSRSYTMLRSQNEELRRLLQNMQIISENLLDLSQDARKYPSYIFFGDKPLESEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6STA5</accession>
    <name>D6STA5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD1260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FliF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871270.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1260"/>
    <dbReference type="EnsemblBacteria" id="EFI33921">
        <property type="protein sequence ID" value="EFI33921"/>
        <property type="gene ID" value="Dthio_PD1260"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004862">
        <property type="entry name" value="FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="12">
        <location>
            <begin position="46"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="13">
        <location>
            <begin position="253"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI33921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="532" mass="59390" checksum="6358BD1DDBD13267" modified="2010-08-10" version="1">MPPFIQDLQEKVTSLWSSSSVPQRILVAGLGLSVIAAFAFLMFFITRPDYRVLSSDLYPEDASRVVEILESENVRYQLEDDGTTILVPADQVHKMRLAISGEGVLRGEGMGFELFDDTGIGQTDFVQNVNYQRALQGELARTISEFSEVEHARVHLVMPERSLFIEEETPPSASIVLQLRSGQRLESSQIQSIVNLVVTGVEGMDSDRVTISDTSGRVLYEPQKDLLDGMSSTQLEYQLNFQRDLERRIEHMLTPFAGPGRVIAKVNADLDFDRRTTRQEIFDPDGSVVRSEQRSTEESSGGTFMEEGVPEPDFQQGFEGPATTQETSRSDRTTNFEISREEHNIVASVGSVDRLSVAVLVDGQHVTDDAGEMVYEPLADEEMQRIQQLVERAVGFDQERGDSIEVSSVDFGAPEVEPEPTLMDNLAQYFQTFGKPLLNALLVLLFLLLVVRPIIMTILKPKVAEEEGEEAEGLPEGGEREALAPGMSEEEVEGMQDQKRVEGIKVFASQLAEENFDQAFAVVKKWLKEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6STA9</accession>
    <name>D6STA9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871274.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1264"/>
    <dbReference type="EnsemblBacteria" id="EFI33925">
        <property type="protein sequence ID" value="EFI33925"/>
        <property type="gene ID" value="Dthio_PD1264"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="186" mass="20128" checksum="D9307C2C39C4D6DB" modified="2010-08-10" version="1">MDNSLDYQINKELGESYLFMGELDKAEEHYKKAAGSNGVHAEPYLGLATIAVQKGELQKAHSLYSKASSVEASDKALAGLALVEAEIGSLEKAFELLQQALTLKPSNLVALLAMVQVGHGLQRLQEVLPYLEAYLEVEPENNDVRFALAGCLKTLGHASEAQEHARRILEQDPENTAAGELLANVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STE5</accession>
    <name>D6STE5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871310.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1300"/>
    <dbReference type="EnsemblBacteria" id="EFI33961">
        <property type="protein sequence ID" value="EFI33961"/>
        <property type="gene ID" value="Dthio_PD1300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCYY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2070006at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10312" checksum="0FCB9CA749288966" modified="2010-08-10" version="1">MINEKTILQARLKNCLLTIVEMEPLLSRISVHHELKKEFRQLKEISGKIAGMELSDAEVERIENATEVFLKELEIPGEFLPQENHETLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-02-10" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STI1</accession>
    <name>D6STI1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS system mannose/fructose/sorbose family IID component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871346.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1336"/>
    <dbReference type="EnsemblBacteria" id="EFI33997">
        <property type="protein sequence ID" value="EFI33997"/>
        <property type="gene ID" value="Dthio_PD1336"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1632067at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03613">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="253" mass="29246" checksum="C3B175689FB0E2FD" modified="2010-08-10" version="1">MAHLDFKTLSRCLLRSQLVGCAFNTRGLQNIGLAYALEPGLQKIYSGDPQGLQKARRRHLKFYNTHPFWNPLLVGIFLTLENKISRELFPPASLPGVKSTLVYTLSAIGDSFFSGSLLVTWALVTMVLVMAGFFWPAIILGIIFFLALQLFKMYIFHQGYVQGIVFVQRLKRWNLINWGTRLKVVNALLVLCFWLVIWPFKWHILNFIGVCFLGLIMAWVFRRIQWSREIFLTGVLLLSLLLPWDQMVNNFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6STJ2</accession>
    <name>D6STJ2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871357.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1347"/>
    <dbReference type="EnsemblBacteria" id="EFI34008">
        <property type="protein sequence ID" value="EFI34008"/>
        <property type="gene ID" value="Dthio_PD1347"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="395" mass="43380" checksum="ACE39BC30D1FC956" modified="2010-08-10" version="1">MSVLNPQVADYLEKASWIRRMFEAGSELKQKYGPENVFDFSLGNPDLPPPTEVGQGLEELGRNACKPYALGYMPNAGLPGVRKALAGVVSREQDTEVAPENIVVTCGAAGGLNAFFRAVLRPGDEVVCPAPFFVEYYFYTENFQGVFVPVPSKPVSFELDLEAMQRAITPNTRVVLINSPNNPSGQVYSREELEGLVRILEDKSKEYGQPILLISDEPYRFLTYDDTVVPPVMALYPYSLVVSSYSKSLSMAGERVGYLAVHPEMPGGDELLQGLNLTNRILGFVNAPVIGQILLEKALHVTVDTGVYSARRQAMAEIMDKAGLEFSLPKGGFYFFPKAPDGDDQKFVRDLFEENILAVPGSGFGYPGFVRFSFCISEEVIRRAETGLVRAVGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STJ9</accession>
    <name>D6STJ9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1354"/>
    <dbReference type="EnsemblBacteria" id="EFI34015">
        <property type="protein sequence ID" value="EFI34015"/>
        <property type="gene ID" value="Dthio_PD1354"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="294" mass="33802" checksum="A080D26401E48EF5" modified="2010-08-10" version="1">MSYPVTAGLFVLLGQLVRRMSRGQALRLGRLLGYLACDVFRIRRNLVQDNLKQAFPEKTETQIQHLTRQTYITQARNVIELLRIPLIRNEQDAQELLDIQADASFYEAINQSRGAVVVPAHLSSWEAIAVCAGILLKPLHIVVKPIKNRYLDRQINRLRTMHGNSLIQKDQALRQGRSALETGGILVLLGDQSNKHGNFYTEFLGRKARVAQGPAFLALKAGLPLFVETCRSLDNGRYQVDINQIATNDLDYTRESIRTLTVRYTRVLDKFIRDHPEEWLWLHDRWKKPKVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STK1</accession>
    <name>D6STK1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mn2+dependent serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1356"/>
    <dbReference type="EnsemblBacteria" id="EFI34017">
        <property type="protein sequence ID" value="EFI34017"/>
        <property type="gene ID" value="Dthio_PD1356"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="273" mass="31682" checksum="37141E7F033BA7D9" modified="2010-08-10" version="1">MTEKSCHHRRYGSLYTLYLDQQAIEFLDSGLSPEEWFRCNICNIKSDEKKESGIVNISSSKAVFVKRFFIDNAWQKILYALYKDQALQTFKLSLDMASAGVPIPRPLAVIRDPERKKKSVYLLSEALRHYRTLKKTIIDLKDPAQVQDVLDYLAVLLAKMHNAGFFHGDMKWKNIMIDARSKNSACFIDLDTAGRLISRRDRRYARDLARFCIDIQESLPQQEQVCRFITAYSRFATRTPKSIMEHTLPYHMKIAAKHRAKYGIEPTPLKLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6STL5</accession>
    <name>D6STL5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MucR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ros/MucR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871380.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1370"/>
    <dbReference type="EnsemblBacteria" id="EFI34031">
        <property type="protein sequence ID" value="EFI34031"/>
        <property type="gene ID" value="Dthio_PD1370"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1797085at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041920">
        <property type="entry name" value="ROS/MUCR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008807">
        <property type="entry name" value="ROS_MUCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05443">
        <property type="entry name" value="ROS_MUCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="132" mass="15038" checksum="375E04A67F2D8AD8" modified="2010-08-10" version="1">MEEYLKEALEIVKAQASVRNMTEEEMSAMILALSRGIRETAREMPGAASQSAAPGVDPARAIREKSILCLECGKSFRVLTKKHLGKHGMTPEEYKAKWGYKKNTSLVARSLTRNRRKRMQEMQLWKKRQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STS1</accession>
    <name>D6STS1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871436.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34087">
        <property type="protein sequence ID" value="EFI34087"/>
        <property type="gene ID" value="Dthio_PD1427"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032066">
        <property type="entry name" value="GP3_package"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16677">
        <property type="entry name" value="GP3_package"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="147" mass="16772" checksum="AC051CF4CF2EC99D" modified="2010-08-10" version="1">MRRRKPGRPRLYSNAPQMQERINSYFDACHEWEEIPTVSGLCLHLGFTDPSALKYYATASKAHAHFSKAIRRALMKIEACKAQALVDGELEPGRLRGLMFDLRVNHDWREKVSVKAEEPGNAGCGVAVIGWEKFNENWQERMLKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6STT4</accession>
    <name>D6STT4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1440"/>
    <dbReference type="EnsemblBacteria" id="EFI34100">
        <property type="protein sequence ID" value="EFI34100"/>
        <property type="gene ID" value="Dthio_PD1440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8930" checksum="D99025C539223195" modified="2010-08-10" version="1">MKFSDVVTESGQYKVTVTGPDHRGFIRFVNSKDQVMSWMVRTDGRVWKGFTLHPTTTGIKKGSKAFVADWCLDWAANGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6STW2</accession>
    <name>D6STW2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34128">
        <property type="protein sequence ID" value="EFI34128"/>
        <property type="gene ID" value="Dthio_PD1470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8299" checksum="4C2C2E36236C8EC5" modified="2010-08-10" version="1">MQSILSDRQENPSRTLYSSKQCVRSTRVKLKASRAGEDFFGTVNFVAHPSETSYTETTFVSRDKRAALPLTVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6STW7</accession>
    <name>D6STW7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GmhB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871482.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1475"/>
    <dbReference type="EnsemblBacteria" id="EFI34133">
        <property type="protein sequence ID" value="EFI34133"/>
        <property type="gene ID" value="Dthio_PD1475"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="198" mass="21611" checksum="48092AF639664AA3" modified="2010-08-10" version="1">MDIKNIFLDRDGTIIEDRHYLSSPDQIVFLPGVVQTLQAMQAAGCSLFLVTNQSGIGRGYFSMADYQLVHQALLEMLAEQNVFMKDCSFCPHAPEADCSCRKPGTGMWETISLRHALQANQSIMLGDKQEDISFGRNCGFAASILLGTGKGEKSMAGLGIPPLPAGWMEPEAPDLPGMPAAVAMDLPSAWQWLQQRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU26</accession>
    <name>D6SU26_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871809.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0432"/>
    <dbReference type="EnsemblBacteria" id="EFI33117">
        <property type="protein sequence ID" value="EFI33117"/>
        <property type="gene ID" value="Dthio_PD0432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="11157" checksum="157E19DEE44FC2D5" modified="2010-08-10" version="1">MRTHFDPLQYLEYELRLDLSLDSRGSIVVKGLWSLHPHQKQKAQATLTTYNKLLRLQLNAPSRKMRPSVRKLLAQGKIEIKGGQYVKRGDLLQNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU37</accession>
    <name>D6SU37_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871819.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0444"/>
    <dbReference type="EnsemblBacteria" id="EFI33128">
        <property type="protein sequence ID" value="EFI33128"/>
        <property type="gene ID" value="Dthio_PD0444"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033Z70">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879053at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17415" checksum="E7BF9242475CF508" modified="2010-08-10" version="1">MGQETIPHQSRMDAARKLVVDSAFVPCPAEDGDEIYPNGIFHFNITKMLEHINQNPGQYLLEEIPVENLSLFSSSLNEDYVSIADITQPIILAEISPGRYVVIDGHHRLEKARIMMVKAVPAYRLHVHQHIPFLTEKRAYLAYVEYWNSKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUI5</accession>
    <name>D6SUI5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsA</name>
        <name evidence="8" type="ORF">Dthio_PD0279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871658.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0279"/>
    <dbReference type="EnsemblBacteria" id="EFI32965">
        <property type="protein sequence ID" value="EFI32965"/>
        <property type="gene ID" value="Dthio_PD0279"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="408" mass="43603" checksum="51D27989E0B19583" modified="2010-08-10" version="1">MAKSDLIVGLDLGTTKITSVVGEMTPEGVDIVGIGTSPSTGLRKGVVVNIEQTVQSIKKALEEAELMAGCEIQSVYAGIAGSHIKGFNSHGVIAVKGGEVSNRDVERVLDAAKAVAIPLDREVIHILPQEYIVDDQNGIADPLGMAGVRLEVKVHIVTGAVSSAQNIVRSCHRSGLDVSDIVLESLASSKAVLTEEEKEIGVALVDIGGGTTDVAIFGEDSIKYTGGIAIGGANLTNDIAFGLRTPMVSAEKIKVRYGCSMADMLEEEEIIEVPSVGGRSPRKLSRHVLAEICEPRMEELFLLVDQEINRSGFKNSTGAGVVLTGGAALIEGAQELAEQIFNMPTRIGYPRKVGGLKDVVNNPMYATAVGVLIYGAEKESSEKQFRIRDKNMFNRILSKMRKWFVDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUQ8</accession>
    <name>D6SUQ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871731.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0352"/>
    <dbReference type="EnsemblBacteria" id="EFI33038">
        <property type="protein sequence ID" value="EFI33038"/>
        <property type="gene ID" value="Dthio_PD0352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2046642at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="110" mass="12432" checksum="1ED39356CF835F90" modified="2010-08-10" version="1">MLDVFKKGVLTGLGLVVVTAEELEKKVNQMVEKGKISAEEGESLVREFIQKSENQQSEVQEWLLNTVKTGRERLELAGREEVQDLEARVSSLEDRVSALESLKMQAEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUS2</accession>
    <name>D6SUS2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871745.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0366"/>
    <dbReference type="EnsemblBacteria" id="EFI33052">
        <property type="protein sequence ID" value="EFI33052"/>
        <property type="gene ID" value="Dthio_PD0366"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="117" mass="13315" checksum="2142D2873B84B139" modified="2010-08-10" version="1">MFFESRNINDILVIRPMVERIDAENSSSFKGWMVDYILQGKEKVALDLSEVEFMDSSGLSALLSTVKTMKNRGRLVFFGVRPNVGKLFSITRLDRGVFEIHPDEQSAVEALRKDENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUU9</accession>
    <name>D6SUU9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0393"/>
    <dbReference type="EnsemblBacteria" id="EFI33079">
        <property type="protein sequence ID" value="EFI33079"/>
        <property type="gene ID" value="Dthio_PD0393"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="24999" checksum="381EB0DB77208921" modified="2010-08-10" version="1">MISKYKLPGSPLISIGVTGHRAHRLNPNIESKFSIFISQILDIVLKKLSTSCFNAVHTQDNPQICMVSALAEGADRIFAREALKNKLNLCCVLPFNRNEYKKDFQDQTSLDEYAKLLSEASSVIELDYPRSGIQGYQAVGRKIVDMCDLMIALWDGEPARGPGGTAHVVEMTLTASKPVLWFPLVQERGSRFLMPGHNSKEMPLEASQEGWENSLEEWLMIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUV8</accession>
    <name>D6SUV8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0403"/>
    <dbReference type="EnsemblBacteria" id="EFI33088">
        <property type="protein sequence ID" value="EFI33088"/>
        <property type="gene ID" value="Dthio_PD0403"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="134" mass="14864" checksum="02F871F8A8228667" modified="2010-08-10" version="1">MRVVLDANVIIAAAAARGVCEAVFELCLEQHQLIICEGLLREIDEKLRFKINVPAPVVAEYLQLLRNNTETVTPSAVDPESCRDPDDLVIPGLVSPGNVEAIVTGDQDLLVPGSYEKARIISPREFWEQERRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV00</accession>
    <name>D6SV00_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0045"/>
    <dbReference type="EnsemblBacteria" id="EFI32756">
        <property type="protein sequence ID" value="EFI32756"/>
        <property type="gene ID" value="Dthio_PD0045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="53" mass="6009" checksum="023050A95144A756" modified="2010-08-10" version="1">MQDTNGVSRLGERLRQEIRLCSENYHERKLRLYKRATAVLGAAVIGLIIIAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV04</accession>
    <name>D6SV04_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0050"/>
    <dbReference type="EnsemblBacteria" id="EFI32760">
        <property type="protein sequence ID" value="EFI32760"/>
        <property type="gene ID" value="Dthio_PD0050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="12675" checksum="2C2329E541928335" modified="2010-08-10" version="1">MGRPPEIIPVFRLIQPGLLTGFLTGCPTRHFGAVFLLAPVSVVGTKGFATVQADNLLALFATQELTLLCLRQAKKAVTARQKKRKKKKDRKEDKIKNIFFFSLLEEDTRIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV44</accession>
    <name>D6SV44_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871882.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0098"/>
    <dbReference type="EnsemblBacteria" id="EFI32800">
        <property type="protein sequence ID" value="EFI32800"/>
        <property type="gene ID" value="Dthio_PD0098"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2171790at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_5" evidence="1">
        <location>
            <begin position="801"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="2470" mass="273628" checksum="FFB9111AEBCDF129" modified="2010-08-10" version="1">MSFEFHTDIEISVGTRFNELFTDTEELYTHYEVWTGRIDEEGRVVDGNSLGWLSIEELADIAVSYDQINHNSLYVRGREEEIGTGDWHHNDWRGGDYFDFPGPPEIEFHTDIDISMETSFAELFTDEDDTATWYQIWTGEMDEEGVVQGSLVDTEAGRGWVQAEDLDELMVTGDQVGHNTIYVRAHSPELGLRDWEHNDWRGEEFFEFPEPWDYELTIEQSYAIEDTPLDQMFSITPPSGVKDDEIWLQVKVDGEPLQTSLGGGWVRGDQLDQEVFPVADAGKEISVVPYYKGEMHEDDEVSWEVRDESPGSISGEIVLDNEGVDRDVEVTVEANGEAVTLEILEGETGAEYIIEGLEAGNYEVSAEVTGDAVGAYEIDNGVLEDITVEAGEVNDGNDFNLVSLPGSIAGTVSIFDVEGEADPEAAIEITVSAENGETYEYIIETADDDGQSEYAYLLEGVYAGTYTVTASVDGYELAEEQQVQVGAGEEVEDIDLTVTAIDDPEYTVTFIEDEEVEDWTVTVYSDEERTEEVGSADAGDEEPFYQAAKDLKDGEYWFTVELDGYQDYEGDFEVDGQEKTVDFELDALASDLWAWMWEAEYDPEEEDYLVTFDIDNDGAVDTENLEITISLDDEEIYFDDETVISAGETYEGEFWLGEYYDLENLVPGQEYTLTLEVQDDYDSDEDSETFTAFAEPAYFAVVSVDADPIDQGEEASVSVDIENTGGEEGTQDIVLTIVVPEADDIVVTEEDFTIGAGETETVEFTDIDTTGLDAGDYDIQVATDDETETFDNALTVEAVVENLTVDTTSPEDGDTDVEVDTDITVTFDQNIQLLDTGWEHITLSGTALSEDEVSVEDNVLTITPDEALAYDTEMTVEVGEDAVGWEGDEDVKLEEAYDFSFTTEQEPVTYTVTFSEVEEVDDWTVTVYADEERTEEVGSAEAGDEEPFYQAAKDLKDGEYWFTVELDGYQDYEGDFEVDGQEKTVDFELDELTSDLWAWMWEAEYDPQEEDYLVTFDIDNDGAVDTENLEITISLDDEEIYSDDETVISAGETYEGEFWLGEYYDLENLVPGQEYTLTLEVEDDYDSDEDSETFTAFADPAYFAVVSVDADPIDQGEEASVSVDIENTGGEEGTQDIVLTIVVPDAEDIVVTEEDFTIGAGDTGTVEFTDIDTTGLDVGDYDIQVETDDETETFTDALTVVDVEEPYFQIETLELEEFWDFQTGTANVQVVNQGQEGVRDISLTVDGDVIEVWEDVELSKGERWNQEVDIDPDELDLDTGWYNLELDTEDDQESLYFQIKESPEYITVFETTPEKGDKNVSIDTDIEVIFDQDIQLLDAGEIEITADEESFDFTASVTDDVLTITPDEDFAYDTEITVVINTDAVAWDLNPGVTLEEDFSFIFTTEEGPVVDDITVDGPDSLTIPSEGVTMGEYSAVVFDQFGDEMPDEEVIWSLEDLGDLEGISIDENTGEVTVSTEAYEAFEEGDSFTVVATSETDEEIYETMEVDLELEDLVVTTVNVDGPGTILIPEEGETEVVTYEAEVLDQYGAQMEEEVTWSLDQEVDGVTIDDGVITVTHDADPDEEFTVIATSVSDEDVTGEFEVSLTDEAPAVDSIVVEGDETVVVPSDGENSYTYTATVFDQFGDEMPGEDVSWILEDLGDLEGISINDIGLVTVSADAYEAFEEGDSFTVVATSETDSTVTETMAVDLELEELRVDQVEIVEGPDSMEIPPSDEEPNTATYTATVFDQYGAEMDEDVIWSLEEEITGITIDDGVVTVSTDAYDEFEEGDTFTVVATSETDSTVTETMAVDLELEELRVDQVEIVEGPDSMEIPPSDEEPNTATYTATVFDQYGAEMDEDVIWSLEEEITGITIDDGVVTVSTDAYDEFEEGDTFTVVATSETDSTVTETMAVDLELEELRVDQVEIVEGPDSMEIPPSDEEPNTATYTATVFDQYGAEMDEDVIWSLEEEITGITIDDGVVTVSTDAYDEFEEGDTFTVVATSETDSTVTETMAVDLELEELRVDQVEIVEGPDSMEIPSDDEPNTGEFTVSVLDQYGTEMEDVEVTWNILEDIDGVSIEDGTVTVTAAAYEEADSFTVEVSANGETDTQVVDLELEELRVDDFSLFVEDINAGEEPVLEFTDAVDQYGADLEGDYTADITINGDEYIDVTLSFSEGAATFEDATSIEEANDYTATATIGDITNDYTFTVEQLATLDITDITIDPEEPTEGDEITVSGNVFVDIADAQNVTVSLTITDDESEVVFSAEKAWEEITMGESEEFEFTWDEDVEVGDYEILIEANADNAVEVTETESVTVSEVPDFNVIEADDEPASVSQTLIGTDDQIDVFVFNFESDGNNAFAKFAESIIQNYNYDDGDIILLVDQMDSLDEVSHVSTDSVRNVDEGAIINFFEDPGDPDQSILIEDAEVDTPFGATLQNVVDVRFEVEKNEVIEEMGLNTYIEELIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV56</accession>
    <name>D6SV56_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_37 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871894.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0114"/>
    <dbReference type="EnsemblBacteria" id="EFI32812">
        <property type="protein sequence ID" value="EFI32812"/>
        <property type="gene ID" value="Dthio_PD0114"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1946648at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_37" evidence="1">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10623" checksum="D84FAC587E3D88F4" modified="2010-08-10" version="1">MSNNHFESVWDAIENTPEQAENMKLRSVLMMAISEHIQRNEISQSQAASLFGVTQPRISDLKRGKINLFSLDSLVNMAVTAGLRVEIKVHDLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJU4</accession>
    <name>D6SJU4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869272.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3601"/>
    <dbReference type="EnsemblBacteria" id="EFI36147">
        <property type="protein sequence ID" value="EFI36147"/>
        <property type="gene ID" value="Dthio_PD3601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="61" mass="6834" checksum="6B4D1B834CA06DDB" modified="2010-08-10" version="1">MTDSEKALTILQATNQGAILDKHHHLILQAALNGELGDATRLIFEDLWDQYVREGDADEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK30</accession>
    <name>D6SK30_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869355.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3690"/>
    <dbReference type="EnsemblBacteria" id="EFI36233">
        <property type="protein sequence ID" value="EFI36233"/>
        <property type="gene ID" value="Dthio_PD3690"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034ASQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011566at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="10279" checksum="6D4E6100563E74E6" modified="2010-08-10" version="1">MRDELFWDCHDPTPELEIQRAINFGGFDYIDYIQKKYGMDRFRQTLINNRNLSRKAVNYWCMVLGIDRNQTRSYQTENIWLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK66</accession>
    <name>D6SK66_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YlxR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3732"/>
    <dbReference type="EnsemblBacteria" id="EFI36269">
        <property type="protein sequence ID" value="EFI36269"/>
        <property type="gene ID" value="Dthio_PD3732"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10358" checksum="3539AE3056958389" modified="2010-08-10" version="1">MIKNNPLPDQDMAGTKHVPVRTCVVCRDRKPKADLERYVCPANPEQGLQPDPGKKRPGRGFYTCKSPECAGKLARFRGWRHKCKRGKDNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK71</accession>
    <name>D6SK71_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truB</name>
        <name evidence="7" type="ORF">Dthio_PD3737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869393.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3737"/>
    <dbReference type="EnsemblBacteria" id="EFI36274">
        <property type="protein sequence ID" value="EFI36274"/>
        <property type="gene ID" value="Dthio_PD3737"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="35"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="184"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="309" mass="34197" checksum="E0CDAB01D92FA6C5" modified="2010-08-10" version="1">MSPGPRSSKAFHPDGVMVLNKPEGPTSTACLNKIKSRFKLKKLGHAGTLDPMARGVLVALLGQATKLAPYITEGRKTYWGVIRLGVSTDTYDMQGTVLEEKDCSEVSPETIEREIKSWEDLKEQPVPAVSAAKHQGKPFYALARAGQEVPCKTKEIDIYQAQVLNIEPPLVEFRITCSAGTYVRSLAHSLGMRVGCCAALAELVREKSHPFSLDQAVDLDTLMEARDLNEHLLPIPRAMSHWEHVRLDPEQEAFVRNGRPIEARNAPRTVDGQHPRALLLSMDGSSLALAEARKTDGRLMWSIIRGLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK99</accession>
    <name>D6SK99_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3766"/>
    <dbReference type="EnsemblBacteria" id="EFI36302">
        <property type="protein sequence ID" value="EFI36302"/>
        <property type="gene ID" value="Dthio_PD3766"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167675at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="64" mass="6672" checksum="E423A94965B1BB48" modified="2010-08-10" version="1">MDCLHVNIQVDAGTGPGTVPHLFFSDGQFLAVGVGKISAGQSPGLVPVITNQDPLNGYVYTLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKD2</accession>
    <name>D6SKD2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD3802</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869454.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3802"/>
    <dbReference type="EnsemblBacteria" id="EFI36335">
        <property type="protein sequence ID" value="EFI36335"/>
        <property type="gene ID" value="Dthio_PD3802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="282"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="354"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="405"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="481"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="535"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="658"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="730"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="861"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="930"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1170"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1324"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="14">
        <location>
            <begin position="1528"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1390"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1486"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="900"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1590"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1390"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1407"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1500"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="1224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="1373"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="1567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI36335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1625" mass="184074" checksum="7181388C358458B4" modified="2010-08-10" version="1">MTTKNSSFPPSQNLPGGTGFMDCRDLLENAPTGIFTSTPEGKLIYVNSALARMFGYDSPQDMVESVTDIASQLYANPADRAAFLRHLEDKKELVNHEYRMRRRDGTEFWVSRNARAVLDEDGRLVACQGFTTDITERKQVQEALGASEEKHRLLFETMAQGVVYQDAEGVIISVNPAAERILGLTSEQIVRRSSMDPQWKMIQEDGSEVPGSQHPAMTALKSGKTTGPVTRGVYHPVSNDHIWLSITAVPMFHPGDSKPCQVYTTFEDITRLKEQHDELRKREQMFTNLFEKHAAVKLMVDPDTGAIIDANHAAAEFYGWSREELKKKYIQEINTLSPDELHKELERARSRDKFWFEFQHRLADGSIRDVEVFSSKIESHGRQVLYSIIQDITDRKKAEKELLESRERFSLAMEATKDGLWDWDVSTGEVYFSPGYVSMLGYDSAEVPGHVQTWLDLIHPEEKEKAYQANLDCINNLVDSFAVEYRMQARNGNWVWILGRGSAVKRDETGKALRMIGTHTDITRRKLAEESLREQEFFYRSILESINDAVFLTDAQGDLTFVCPNAHVIFGRSRQELLEMANIEHVLGSRLIKSGELVEDEQEISNRECAIKDSRGHWRYLLVNIKRLPEQLHEKGLYLYCCRDVTEKKKTEDTFRQTLERYRLIVENANEGIRILDRQARLSFANRSMALMLGYSPEKVTDHSIWDFIHPEDQDKFNRIWENRKSGKAEKYELRLIHRNGSTVWTLVSSTPLFKDKEFNGSFALVADITEKKHLEEELRKQQEILTSMEEMARVGGWEWDIDARTMTWTRGAYLIHDFEVNHNPTLSSELISKSLECYYKEDRSRVSNAFQACAEKGVAYDQEFPFVSARGRRLWVRTAAWPVYDSGRIVRVAGHIMDITELKQSQLDLQEARDKAQEATRAKSEFLANMSHEIRTPMNGVIGMTDLLMDTELRPEQRSLAESIQSSGEALLALINDILDFSKIEAGRLELESVDFNLRYLLEDLASLMAVRADEKGLELICLPDPDVPAQVQGDPGRLRQILTNLVGNAIKFTHQGEVVVRVQRSEVSADDVLLLFTVQDTGIGIPEDKIDLLFNKFSQVDASTTRKFGGTGLGLAISRQLAEMMGGEVGVQSEYGRGCKFWFTARLTLQKKQEEPLPALPQDLHGEHILIVDDNETNLEILKKQLEAWGVEVEQASGGHEALRILDRVYSEGNSFAMAILDMHMPAMDGGELGQRIKKSGKFNDLPLVMLTSLGRPGDAKIFEEQGFNAYLNKPVRQSELFDTLLTVLSSAGKAPGHSIITRHQAREIKRQQSELIKFKGHVLVAEDNPVNQKVAVGLLNKMGLSADIVDTGLKAVEALQNQSYDLVLMDVQMPEMDGLEATQEIRRMEHGTEEREQRTGDRRWESQPLNPSTPEYHNPSIPKSFNPKIPQSLNPKIPIIAMTAGAMNQDRDRCFEAGMDDYVSKPVSHQELLKVLNRWLEKEDGHDGDTGETGPSKDVAPASTSEQPENPVFDQEALLTRMGNDSELACEILTLYLEGSPANMAVLKEALDHKDWKRAFKEAHSIKGNSANAGCLRVSETAKEIEKDLQEGSVDGLQDKATELEKELEKCRMEIKSFLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKH4</accession>
    <name>D6SKH4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tripartite ATP-independent periplasmic transporter DctQ component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869493.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3849"/>
    <dbReference type="EnsemblBacteria" id="EFI36377">
        <property type="protein sequence ID" value="EFI36377"/>
        <property type="gene ID" value="Dthio_PD3849"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1947990at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="170" mass="19946" checksum="DBC1888C93297FEE" modified="2010-08-10" version="1">MPKILRLIGKFYDNFEEFFCALTMGIMVACLMVQVSVRWTTGSGMAWTEELSRYAFVWTVFIGAALVAKHGSHVRISAQFFLLPIKARLVCRFFTDLLWIAFNLYFAWLSWQVLQDGLLFPHYSPVLGIVREYVEMIIPLGFVLMSWRILEGYIRRWRQGTLKELVEQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKK2</accession>
    <name>D6SKK2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="4">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbiA</name>
        <name evidence="7" type="ORF">Dthio_PD2622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CbiA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868347.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2622"/>
    <dbReference type="EnsemblBacteria" id="EFI35213">
        <property type="protein sequence ID" value="EFI35213"/>
        <property type="gene ID" value="Dthio_PD2622"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="692368at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="247"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="4">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="465" mass="50953" checksum="C743FF7955B65A2E" modified="2010-08-10" version="1">MKHTKGLVVAAPSSGSGKTTVALALMAAFARKGLITAPFKVGPDFIDPGYHVRITGRVSRNLDGWMLHEKCNREIFARGADGADVCVVEGVMGLYDGYDGASEAGSTAQIARWLGLPVLLVVDARSMARSFAALVKGFLEFDPECSFCGVVANNVGSRRHLEYLQQAVRDLPGCRLLGGIPRNAGVQIPSRHLGLYTAEDHVLTREMISDLADLADKHLDLDSLLHELTFVQPEPVRERSRPDARVRIGVARDRAFCFYYQDNLDLLEQNGLEPVFFSPLQDEALPRDIHGLYLGGGYPELHAAELAGNRFLLESIHRAGSLGMPIYAECGGFMYLCKSLVDIEDNVHGMAGIFPFTSRMQARRAGLGYRDIRLLGDTPLGCRGSVLRGHEFHYSRIDEQGQAVSVQQVYGATDKSGEQRSCPGWLRNNTLGSYVHLHFLSSPEAGRALARACLSFRDSGLHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKS0</accession>
    <name>D6SKS0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2695"/>
    <dbReference type="EnsemblBacteria" id="EFI35281">
        <property type="protein sequence ID" value="EFI35281"/>
        <property type="gene ID" value="Dthio_PD2695"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="712"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="794" mass="88623" checksum="A603738FD084186E" modified="2010-08-10" version="1">MSRNIFCLSVWVLAFFLLTGCSNPEERRDAYYQKAVTHFEGERYSLAEVEIRNALRIDPDFAKAQLLLGRVYFVQKNWRSSYAALNSAVDLDPDLLEAHLYLGRIYHMAGESEQAEEKARLVLERDPGNADAGIIMATVMIRQGELEAGRMSLEEIIAAHPDREEPYILLSRVLAGQNLAGNAVDVLSAGLEVLPDNRTLMLAMAGVFESVQDYCGAEEEYRRIVAHDPGNGDMHLMLVHFFQRTGQVDEAMKEFQSLMLARPDDNRSYLGLGAMYMEESRFQDAVQVLEQGRAYLGGDYDLSFALAETYLDMGDVPAARAMLHEEIKRDPEHLRALDAGKYLAGIYYDQGDLDKAAHQLDMVLRRNPDDVHARTMQGRIFLARGEPAMAVQTLRRAYREERDDPEIPLLLARAHFQNNEPLMAVEYLRGVSRSSPGYARARQELAEHHLGQGDHLRALQEIDRVLSADPGNMPARIQRGDVLAMKGDASLAAEEYSLLLQDEEWAGTGHYKLGVLEASRGNFALAHSHLEKALARSPLNQQVLQARVMVDLSQNRVEEAGTYVQELRAEHPGEAFLALLHGDVYLAGQDPVMAREMFALAASMEPEWMVPWTRKATLDAEAKNWKPGIAALEKALLLEPESIQVGFMLGTFYEQAGQKDMAEKQYAAILERDPGFWPAANNLAFMYASSSEEQKLQKALELASKAAKSNHPQALDTLGWTHYRLGNLDMALEKLDLARQGDPQNLDIAYHLAVVLAEIGDRVGALGVLEQAMSSPGADGVSARMLELRQELDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKU2</accession>
    <name>D6SKU2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligosaccharide biosynthesis protein Alg14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2718"/>
    <dbReference type="EnsemblBacteria" id="EFI35303">
        <property type="protein sequence ID" value="EFI35303"/>
        <property type="gene ID" value="Dthio_PD2718"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="PTHR12154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="154" mass="16986" checksum="7E256C70A83D69A9" modified="2010-08-10" version="1">MVNICVGASAGGHLNQLILLIDNATNWPCKPDLCVTTHQQVVGKLSNKYGNTVVLGDCNRNTILGIINVLYKSFLIAKKYKPKVIISTGSLPIAIFCLWGKIMGARIIWIDSIANIDSLSMSGKLVYRFADLFLVQWEELVSIFPKAKYSGKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKW4</accession>
    <name>D6SKW4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868457.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2740"/>
    <dbReference type="EnsemblBacteria" id="EFI35325">
        <property type="protein sequence ID" value="EFI35325"/>
        <property type="gene ID" value="Dthio_PD2740"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="170"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="311"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="579" mass="66835" checksum="0ED1D4C5D8A90627" modified="2010-08-10" version="1">METNTNDINYYRDLLKRRKWYLVVPFVLLFAASTAVAVMLPSVYRSQATILVEAQNIPEELIRTTVTGYIEERLQTLSQVVLSRQNLEEIIGSFGLYPEMAERNTTEQVVARMRRDILMEPIYAQAANPRQGRATIAFNLSYEGNDPQSTAQVANALVSLYLEQNLRTREERAEGTVTFFRQQLEELRREIDASEADIARFKEENLHSLPELMQFNMQMLERTRSEIDNRQRDIHNLMNRLVNLQGQLALVEPVRFRGGNGRAMSLEEELRFLNNQYLALKAVKADNHPDLVRLRNQMNSLDQETQSRHSLRDLIIHLESKQNELSLLQERYSRQHPDVIRLSREIDILEARIQDLSGQRHLVTRVEDLEPENPAFINLQTQITSTQLDIESTRDKIRDLERTYAMYQRRIENSPQVEQRFKALQRDYDSAQKAFTENMSRLQAAIEARELEEGQMAEKLTVIEPPRASETPVKPNRKAIVLLGFVFASGLSVGTTALAEYFDSSVRDGRTLARVSGIPVLGSIPYLRTRKDVWTTRIMRLAVVLGIMLGVALVLFLIHFYYEPLDVFWLNLQGRVGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL39</accession>
    <name>D6SL39_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868532.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2816"/>
    <dbReference type="EnsemblBacteria" id="EFI35400">
        <property type="protein sequence ID" value="EFI35400"/>
        <property type="gene ID" value="Dthio_PD2816"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012840">
        <property type="entry name" value="NrdG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01094">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="32"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="212" mass="23596" checksum="64097531973CB8BB" modified="2010-08-10" version="1">MQDLDYSAWDMLKGYEPFSLCDWPGRISAVLFFGGCNLRCPTCHNASFAWHPESFPVLDCLGVLEQVQRNRNWLEGLVLTGGEVTILPGFDSLLHDLSSLNIPIKLDTNGLSPDCVKLALEHSSIKMIAVDIKGPWHMYPGLTGDRAAPGQARDCLGQILELAADSPERFMFRITRVPGLSDPDIENVKAWLPPGFELKVQDYRPSRITANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL72</accession>
    <name>D6SL72_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868565.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2853"/>
    <dbReference type="EnsemblBacteria" id="EFI35433">
        <property type="protein sequence ID" value="EFI35433"/>
        <property type="gene ID" value="Dthio_PD2853"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="335" mass="35148" checksum="4E8A1FDC232B2452" modified="2010-08-10" version="1">MHTEFTPVARKLLLSILILGGMLIISSSLGLGFGSTGSMLGSLGEVFFRPQEADQVAAAIIKEIRLPRVVLAAAVGGTLALGGLVFQALLRNPLAEPYILGISGGSAVGAILGMFAGLAAFPGVSMSAFAGSMLTLGLVLILAGGRSPLRRDSLILGGVMMNAFFGAMIMFLISLSQDAQMRSILFWLMGDLSMISPQQLPVLLMVLPGMAVILVLARPMNLLLMGRDTAASMGVNVRLVTLALLVFTSLMVSVAVSQSGLIGFVGLAVPHIFRLILGPDHRLLIPACLLGGASYLILCDLLARTLPPEGEMPVGVVTALIGAPLFIYLLWRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL83</accession>
    <name>D6SL83_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35444">
        <property type="protein sequence ID" value="EFI35444"/>
        <property type="gene ID" value="Dthio_PD2864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="215" mass="24549" checksum="4E4F511CD8423893" modified="2010-08-10" version="1">MDTIHLEMHGVCMKSRSMRMTRTGAEAVLQFCREYNINVYRLFDSPGDVRSLLPAGEHVDCLEECYMYCNDKPDVYAYINDRQVKTLDFGLFQNFTRHAVLDDGGDEHVVIEKAAINDGIMVFEDRGSHLGQLNIQDIRLPIKRSLIDNSLLFNEVYHGHKMFNIKLMELSPGAMQAINVRSNGQKISFIDLLNSVSVSGWRAQNMISEISRTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLA7</accession>
    <name>D6SLA7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868600.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35468">
        <property type="protein sequence ID" value="EFI35468"/>
        <property type="gene ID" value="Dthio_PD2888"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DKN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2071651at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="13317" checksum="9C2B83C6BEA51DB6" modified="2010-08-10" version="1">MKDGPACLDIALELGREELTHLQEANLDEAERLSLKRKDVMDRAFAAPPVQEKDEFLEKLDRLQNLQNRITASARELHATLSQELKKIRTENKRFTGYRKASTVTPMFNAKLHKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLB3</accession>
    <name>D6SLB3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2895"/>
    <dbReference type="EnsemblBacteria" id="EFI35474">
        <property type="protein sequence ID" value="EFI35474"/>
        <property type="gene ID" value="Dthio_PD2895"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="107"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="278" mass="31826" checksum="7AD6F44F5214AFA5" modified="2010-08-10" version="1">MSTSKAVEAFMGYQRINSGEKTIKNYKILLHKFDGHLGEKEISQVTSEDIFNFLVQNTEGQKQSTKRLKFTLIKAFFNFITANVDEKLPNPCHTQVLRKSFRDPTGRQWNILEKDVVDEIIFRTDNPRNRLMLELMARGGMRIGEVLKLRADDLDDRKLFIDRPKSGRQSEVVFIPKKVAERLREYIRSNGISPAERIFPIGYTGARAIVKKSGQAVGINLCPHDLRRHAATYASRAGAPLEIVSKVILRHANLATTQRYLGKVSDTEALHWIENIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLE0</accession>
    <name>D6SLE0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35501">
        <property type="protein sequence ID" value="EFI35501"/>
        <property type="gene ID" value="Dthio_PD2924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="224" mass="25638" checksum="CB9F7D3E66802CD4" modified="2010-08-10" version="1">MIRQVLVRTGKVLPDKSEANKQEAREHLVSGNCLYLTPGLYVRLDNLVREHAGMFLEVFDLDERRSGVLEPMDWANCSPAGSDRYRRSSEKVSAEITAIEIANKIPLDEIRSARRLELDLVRDIPLELFYEWLVWHEIHHSVHDDPVVAAGLDNCVHPEIKSAGDRIKIMQAMELEADRASFNRLFPERTLKAATPAGIKKVRSIEPYLVLLHEIRAKRGIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLN1</accession>
    <name>D6SLN1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3020"/>
    <dbReference type="EnsemblBacteria" id="EFI35592">
        <property type="protein sequence ID" value="EFI35592"/>
        <property type="gene ID" value="Dthio_PD3020"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="201" mass="22451" checksum="7EE44D30B69E492E" modified="2010-08-10" version="1">MQVKQXXXXXXXXXXYILFCSSTGKAAVIDPGSDEEMILSELSSLGLVLEYILLTHFHYDHTDMAASLRQRTGARVAIHEADASFYEKQVDEPLRDGDIIQVGQEIRLQVLHTPGHTPGGACYYGHGQIFTGDTLFVHDSGRTDFAYSHRPTLGASIRRIMELPEETILMPGHDYGPTPTSTLGQEKKHNINAVEYRFHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLQ2</accession>
    <name>D6SLQ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868742.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3042"/>
    <dbReference type="EnsemblBacteria" id="EFI35613">
        <property type="protein sequence ID" value="EFI35613"/>
        <property type="gene ID" value="Dthio_PD3042"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="149" mass="17260" checksum="87F4CEBB7C806CA2" modified="2010-08-10" version="1">MSSKCSVEDNSLTCFFPADTSHVEKVLQQLTYIPFLADRERVFFDLSLVLREALNNAIVHGADQDRSMEVECRVSVDSEGIDIVVVSPGHGFDWEKCLEKQLPECPTQSGWGVFLIREYTDHLVFRDQGKRLECRINLDRYQEKDRQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLS7</accession>
    <name>D6SLS7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868767.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3067"/>
    <dbReference type="EnsemblBacteria" id="EFI35638">
        <property type="protein sequence ID" value="EFI35638"/>
        <property type="gene ID" value="Dthio_PD3067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7425" checksum="D08937E7147624CA" modified="2010-08-10" version="1">MSADTEALKKNILDLVLNLEPEEALDAFSGALREVLSRLEDEQRVRFVLALLEKGDEDKISSMVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLT7</accession>
    <name>D6SLT7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA ligase</fullName>
            <ecNumber evidence="9">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ligA</name>
        <name evidence="11" type="ORF">Dthio_PD3077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868777.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3077"/>
    <dbReference type="EnsemblBacteria" id="EFI35648">
        <property type="protein sequence ID" value="EFI35648"/>
        <property type="gene ID" value="Dthio_PD3077"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="596"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="679" mass="75801" checksum="9303F70817AAB78B" modified="2010-08-10" version="1">MNQHQEHIEHRAEELRREINLHNYYYYVLDDPLISDVEYDRMLAELKDLEEKHPGLKHSGSPTMKVGAPPAGQFEHREHSLPMYSLDNSFSLEEVREFVQRIKKQIPDADPYFWAEPKLDGLAVEIIYENGLFVAASTRGDGYVGEDVTDNIRTIRNLPLTLFYTEFFPEYLEVRGEVVIPRQEFTRLNEDKARKGEKVFANPRNAAAGSVRQLDSRITASRPVYFFSYGTGISRFKSGAGWQSQEEIARGLNALGLPVVPGGRICRDPAEVEECYREQLDRREQSDFEIDGLVIKVNDIGLQQRLGFTSRAPRWAMAVKFPALQGRTKLKDIQVQVGRTGVLTPVAILEPLNLGGVVVSRASLHNENEIRAKDLKVGDTVLVQRAGDVIPEVVRPETRERDGTQKEFVFPEKCPACQSPVARIDDEAAIRCLNMSCPARLEQQLIYFAGKQGLDIEGLGRQWIKVLVKKGLLCSPADIFRLSLDDLLPLDKMGRKLAQNMLDSIRLAAQKATLPRLIAALGIRHVGVETAKRLAANYKDLDELAAAEKNSLQMIEDIGPEVASSIAGFFANPQNRKLLEEFKEIGLWPEHAAAAGEDLPLKGKKLVFTGGMHNLSRDRAREIVEKLGGKVSGSVSGNTDMVIAGDNPGSKLSKARELGLDILSEQEFLDLIENWSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLV1</accession>
    <name>D6SLV1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868791.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3091"/>
    <dbReference type="EnsemblBacteria" id="EFI35662">
        <property type="protein sequence ID" value="EFI35662"/>
        <property type="gene ID" value="Dthio_PD3091"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HBG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1967152at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="126" mass="14303" checksum="5BA6F0481D7D2374" modified="2010-08-10" version="1">MGKVTSLPGRNCVYYSFGRCKYEEYLNPGYQSSWQCRVLAFLEKDYDGLISKADAFDLSFDQVEKIWEKRFAGIGSWADLCGSYLPAGSEDDRCACLFGNACVLMMPECTGVCRLYRPRVQKDIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM04</accession>
    <name>D6SM04_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNP-1 like RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868844.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3144"/>
    <dbReference type="EnsemblBacteria" id="EFI35715">
        <property type="protein sequence ID" value="EFI35715"/>
        <property type="gene ID" value="Dthio_PD3144"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2029304at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9359" checksum="2F17F0446A666FA3" modified="2010-08-10" version="1">MTNLYVGNLPWSTTEAQLRDLFAEYGEVSSAKIIEDRETGRSRGFGFVEMENGADEAIESLNGTDFGGRNIKVNVAKPKREARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM16</accession>
    <name>D6SM16_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF374 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868856.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3156"/>
    <dbReference type="EnsemblBacteria" id="EFI35727">
        <property type="protein sequence ID" value="EFI35727"/>
        <property type="gene ID" value="Dthio_PD3156"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07983">
        <property type="entry name" value="LPLAT_DUF374-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007172">
        <property type="entry name" value="DUF374"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04028">
        <property type="entry name" value="DUF374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF374" evidence="1">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="23832" checksum="DDECCB85AB529CAF" modified="2010-08-10" version="1">MRNIYVKMTPLLTFFAVGWSMSIRYKRVNFEKIQDLRNRKKPIVFAIYHNELFPLCYLHRNEGIIAVVSASRDGEILARVLHSMGFNLARGSSSRQGMKAMLAAMRQMHTKGRDAVLTVDGPRGPRHEVKPGIVYLASRIGAHIVPVRVRMSTRHEFSGSWDRFKLPWLWSGCEVVYGRPYKLSSKMGSSEITQEALELKHKLGLLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM77</accession>
    <name>D6SM77_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase DHPS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868917.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3223"/>
    <dbReference type="EnsemblBacteria" id="EFI35788">
        <property type="protein sequence ID" value="EFI35788"/>
        <property type="gene ID" value="Dthio_PD3223"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="981229at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="259" mass="28262" checksum="5A19688ED6FB6E21" modified="2010-08-10" version="1">MLIIGEKINVMLKQIGQAMKDRDKKPIQDLAVSQVQAGANALDINAGPATKNGPEIMQWLVNTVQEVTDVTLSLDTTNAEAMEAGLQVCKNPAIINSTSGDRAKLETIMPMAKKYDADVIGLTMTSAGVSRDANERVAIAVDIMTAMAEFDVPVERLYLDPLILPVGVAQNQAMEVVEAIKMFRQLNDPPIKSVVGLSNVYNGTPERLHSILSSTYLVMLMTVGLDAAIADPMDQRLMESMKTARLFKNDILYCDSYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM90</accession>
    <name>D6SM90_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="15">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD3236</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="15"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3236"/>
    <dbReference type="EnsemblBacteria" id="EFI35801">
        <property type="protein sequence ID" value="EFI35801"/>
        <property type="gene ID" value="Dthio_PD3236"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="652"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="718"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI35801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="774" mass="84979" checksum="F33738D4BD5B9B16" modified="2010-08-10" version="1">MERLKSLKDFKSLEGSLRRQEGNGAKVRASVCCGLPCTALGSQEIARELADESARQGIEVDIVKTGCQGLCQKGPLMQVEPHGYFYQKVKPERAGEMISKTMGSGQPVREFLYRDSFLDEVKEQIQEVPFYSKQVKIALRNTGKVDPHDIHQYIAAGGFKAVKKMFSRMSPDDVLEEVKKANLRGRGGAGFPAGFKWAHTKRSGKGVPKLVIANGDEGDPGAFMDRSIMEGDPFSLLEGMLICAYSIDANFGFIYVRHEYPLAIKTLEKAIKQAEEMGLLGRNILGTGFDFSVFIKEGAGAFVCGEATSLVASLEGQRGFPRARPPRLSEVGGGAWGYPSNLNNIETYACVPPIIEKGADWFLGIGTPGSPGTKVFSLAGKVNNTGLVEVPMGITLREIVDEIGGGILNNRKFKAIQTGGPSGGCIPEQYLDLPVDFDSLWQVGSMMGSGGMVVMDESDCMVDIAKFFLAFCQSESCGKCPPCRVGTYQMLQIMERITSGEGQPGDIERLEKLIETVGEGSLCGLGRSAPNPVATTLRYFREEYEEHIHDKYCRANVCSGMGVFTIDQKACILCGLCRDACAFDAVRERRSSYFIDQEYCTKCKACFEICPVGAVKVKKKAQIAVEKIKIPYEAMVSVKRKAKLTLWDVLKSKPHVVITIYHDSTVADAIRTLHDRNVSSVFVVDDNAKLIGIFTERDVVHCYNKGFSCQDTPVGHVARKDLIKFEPSMGISSAILIASRNKKRHMPIVDGDRILGMVTFRDLVSYLLPEISYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM94</accession>
    <name>D6SM94_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868934.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3240"/>
    <dbReference type="EnsemblBacteria" id="EFI35805">
        <property type="protein sequence ID" value="EFI35805"/>
        <property type="gene ID" value="Dthio_PD3240"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014433">
        <property type="entry name" value="CooC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005647">
        <property type="entry name" value="CooC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="256" mass="27967" checksum="12845237BAEBF2B1" modified="2010-08-10" version="1">MSKTIALVGKGGTGKTTLASLILKFLIQNGHGPVLAVDADSNSTLNLSLGVEVDKTIGGMREDMTQEIRDGEIPAGMSKEAYVEYQMQQALVESSGFDLLAMGRPEGQGCYCYANNLLRRHIDSLAENYPFVVVDNEAGMEHLSRRTTRNIDIMLIVSEPTPVGVITAGRIRNLSRELQLNVEKSRLVINRSSSNIPDNLKKTVQEQGLEPVVLLPADEMILDFTARGQSLLELPGDSKAVEAVDRLCREVITGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMB3</accession>
    <name>D6SMB3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868953.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3260"/>
    <dbReference type="EnsemblBacteria" id="EFI35824">
        <property type="protein sequence ID" value="EFI35824"/>
        <property type="gene ID" value="Dthio_PD3260"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="670657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013589">
        <property type="entry name" value="Bac_transglu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08379">
        <property type="entry name" value="Bact_transglu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="173"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="283" mass="32258" checksum="2D8E0084C8E5DBC1" modified="2010-08-10" version="1">MIYSITNTTVYHFNRGVFFEPHYLRLYPRNDPGQKVLKHSISIDPLPTGYSTGLDVWGNSFVLAWFEGFHSIMQIKSTSKVQTLRTNPFDFVLPGSSQGIPPGLNHQEKTDLKSCLTPRFSRLDNFFSWFDPDTCKRDENHVVSLLSQLTNWIFEHVKLEQRWDTGIIPPSRLLETRQGCCRDLSALFVEFCRQLGIASRFVSGYQEGDEDILEAELHAWAEVYLPGAGWRGYDPSHGLAVADRHVALAAAPDLENIMPVVGTYRGNEARSSMEHSVHMKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMB9</accession>
    <name>D6SMB9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868959.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3266"/>
    <dbReference type="EnsemblBacteria" id="EFI35830">
        <property type="protein sequence ID" value="EFI35830"/>
        <property type="gene ID" value="Dthio_PD3266"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="320" mass="35320" checksum="70666C5C4F3B4535" modified="2010-08-10" version="1">MRKHKNTIQVVAFTVVILACPFFLDAYWIDVINNIGLYAVLALSLNFIVGYTGLFHMGHAAFFAVGAYATGILNTSYDIPIVLLLPVSGLAAALFAYLVARPIIHLRGDYLLIVTIAIVEIVRIALVNDIFGLTGGSNGIFGISRPDFYFFDIRTPHQFFYYIWAFLALSVLLFYNLEKSRYVRALNYIKNDEVAAEGSGVNVDHLKLTAFVLGAFWAGMVGNIYASKMTLISPASFNFWESVILFVIVILGGSGSIRGVILGAFLIIGLPEIFRQFAGARMLVFGGAMVAMMVFRPQGFLPPLPRKYPVHKIQPGEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMC8</accession>
    <name>D6SMC8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868968.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3276"/>
    <dbReference type="EnsemblBacteria" id="EFI35839">
        <property type="protein sequence ID" value="EFI35839"/>
        <property type="gene ID" value="Dthio_PD3276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="446"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="633"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="810" mass="92207" checksum="F62644C9F40EA8F0" modified="2010-08-10" version="1">MEKFTSVDMHVHSRHSTRPSQWGLQKLGCSESYTGPEFIYKRLRDKGMDLVTITDHNCIDGCLEIAHKDGVFVSEEITAHFPDDGCKVHVLAYDISEEQHSRIQEIRFNIFELVSYLQTEDILHAAAHPLFSVNGKMSYENFERLLLLFKIMECNGARDKTQNEALEFILDNLCPLDFEYLQNKYDLKAAGNKPWEKSIIGGSDDHSSLNIGRMFTRVPGNHNLKKFLEQVNKGCSNAWGTPSTPKTMAHNLYSIGYQFCKHKFNLHRYTGQDSLLQFLDQTLHPGQKIPKNIKDSILGFIYKKTGSKGKTPAREFHRLLSRETELMLRTDPEITRMVQSSVNPHEYMGSRWFRFANKAGNRLLSHEAGRLVEQAASAGFLDMFQTLGSAGSLYTMLSPYFVSYGIFNQDRRTSKEFISSFKKRKGIRKSAYQMRVAHFTDTFYEINGVARTMQQLATTAAVTSKDLTIITCRPDSSKSLEMDGVQNFEPMGMLDLPEYPEIKLYYPPVLEMIDYCFERDTTHLHTATPGPMGLAALATATILGLPIFGTYHTSLPQYTGHLTGDHALEALMWKYIIWYYNQLDKVFAPSKSTADELRLKGVRSEKIKVYPRGVDTDKFNPAKRNGFFARHYKIQNKTKLLYVGRISKEKNLQILEKAFQKICEHTSKVHLVIVGDGPYRYEMEYRLKDYPATFTGYLQGEELSQAYASSDLFVFPSSTDTFGNVVLEAQASGVPAIVVDQGGPGENIIQGDTGLVVPAEDSHALKRAILSLLAHPEDLREMGQKARKYMESRSFKKAFEQTWEMYRECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMC9</accession>
    <name>D6SMC9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate uptake regulator, PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868969.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3277"/>
    <dbReference type="EnsemblBacteria" id="EFI35840">
        <property type="protein sequence ID" value="EFI35840"/>
        <property type="gene ID" value="Dthio_PD3277"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194652at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="3">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="3">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="545" mass="63907" checksum="62D8B2304BA2FF1B" modified="2010-08-10" version="1">MHNLLDLKEKIHFMTLEVIRQLESVKRIIRNPDPQVADRVKNRDDLIDNYKAVIENICFSRIHGHHYLTREEADFVRAVNIISNNLERISDFAVNILGQLNHLHDMKTMQSYRYRHYFQQITISLELVVQGLFNRDHELALRICKSEFIVDKLFKKSFRQILEDLHSADNKSDLITCLFIFRYLERMGDSMLNIGEAIIFSVFGEKLKIHQYHALMENLGSMDNELSFEEIGFESIWESRSGCRIGKIMDSGQRNGQAVLFKEGRIEKIAREKANIEKWKSIFPSLVPRIISYSQNSKNASMLMDFLQGCSVQDTVLSRDRESMDNAAFILKETLSIIWHDTLENTAVKPDFISQMIQRLDDVIMIHPEFNFSDFDNSLSRPLPEKLLQILSKIETELSSPFSVFIHGDFNTNNILYNQKNQQIYFIDLHRSRYGDYVQDISVFLVSNYRMPVFYPDVRRAINKINKTIFCFANQFAAENSDKTFHARLALGLIRSFYTSTRFELNRELSRSMYNRSLQLAQLLLAHQGKPWRDFSVPRNIFDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMD2</accession>
    <name>D6SMD2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HPr kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3281"/>
    <dbReference type="EnsemblBacteria" id="EFI35843">
        <property type="protein sequence ID" value="EFI35843"/>
        <property type="gene ID" value="Dthio_PD3281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027597">
        <property type="entry name" value="HprK-rel_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04355">
        <property type="entry name" value="HprK_rel_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hpr_kinase_C" evidence="1">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="361" mass="41165" checksum="DB45C5B440789FFB" modified="2010-08-10" version="1">MHYPITPGQSFLHMLGCSNVQDTLDQSVDLQLDDCTIRVEMDEPVLREKLLRYFKPFLIQNDDQPHIVIKALENPPLKPGISLTDLHPGCSKKRIKEQYINIPGGRVVRKKLSGMLFFMNSSENIAIGPCTENDNQIVNFINNRFIQWKLDQGCLLCHAAAVSRKGQGIILAGFSGLGKSTLALHLMNKGLDFVSNDRLMVRKKKEHVEMFGVAKLPRVNPGTILNNPRLTGILTSEEIRKFSGISKDMIWKMEHKYDVWLDKCFGRDRFKLQSGVKALVILNWSRHGQSLEMQRVNLEKRSELLQAVIKSPGLFYYPSDNFRVLEPDPLDYMKFFQDIPVYELGGGIDFQQASDRCAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMJ0</accession>
    <name>D6SMJ0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nif11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869029.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35901">
        <property type="protein sequence ID" value="EFI35901"/>
        <property type="gene ID" value="Dthio_PD3340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022516">
        <property type="entry name" value="CHP03798_Ocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012903">
        <property type="entry name" value="Nif11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07862">
        <property type="entry name" value="Nif11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03798">
        <property type="entry name" value="ocin_TIGR03798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nif11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8760" checksum="6242D59D5F1E5807" modified="2010-08-10" version="1">MSIDSAREFVNRVCSDNDFAKNLSDYKDVEEFCNSPKAKDAGFSFSTDDLNVVKRELTEEQKANLRCQDENCNWLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMJ4</accession>
    <name>D6SMJ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869033.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3344"/>
    <dbReference type="EnsemblBacteria" id="EFI35905">
        <property type="protein sequence ID" value="EFI35905"/>
        <property type="gene ID" value="Dthio_PD3344"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="137" mass="15613" checksum="EC167AEAF6AF2587" modified="2010-08-10" version="1">MNHDDITRNKAAIIERSLRRMKEEYNLDSDLKQQTHIDALILNLERACQAAIDLAMHLVAEKHLGMPQSSADAFRLLFKSGIISEQTARSMISMTGFRNVAIHEYQSLNMNIVRSIASEKWISLVDFCQELGLKIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SML7</accession>
    <name>D6SML7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869056.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3370"/>
    <dbReference type="EnsemblBacteria" id="EFI35928">
        <property type="protein sequence ID" value="EFI35928"/>
        <property type="gene ID" value="Dthio_PD3370"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1951440at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="9172" checksum="A81B6949365923AA" modified="2010-08-10" version="1">MKTVQITIDKELVQEVDQITQQLRTSRSAFTRKALQEALDRYKRELLEQKHRQGYEKHPVNSEEFPGWEEEQVWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMN0</accession>
    <name>D6SMN0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869069.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3383"/>
    <dbReference type="EnsemblBacteria" id="EFI35941">
        <property type="protein sequence ID" value="EFI35941"/>
        <property type="gene ID" value="Dthio_PD3383"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2176408at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="174" mass="20709" checksum="D8F3399B580CD716" modified="2010-08-10" version="1">MRVAIVNFSRQSLVSPHEIRAAVERLPREHYAKIKIIRYDPERSLALEMAYINNNPESLRARGTYLHDWDSSDSVVVIYPFKTRDGFFHTLYHEIGHHVFFRVLDQGLRDEWFALRRAEKGFVSKRARKDAREDFAETYSCLCFRTHLLYHAPGKADFMRRKVFRSVIATRRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMN7</accession>
    <name>D6SMN7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="9">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisH</fullName>
            <shortName evidence="9">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisH</name>
        <name evidence="12" type="ORF">Dthio_PD3390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EC" id="3.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869076.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3390"/>
    <dbReference type="EnsemblBacteria" id="EFI35948">
        <property type="protein sequence ID" value="EFI35948"/>
        <property type="gene ID" value="Dthio_PD3390"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1726024at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="11">
        <location>
            <begin position="36"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="23278" checksum="9449872F9E41078D" modified="2010-08-10" version="1">MIAILNYRAGNLTSVKRALDHEGIPCRITDDAQTLAQSQGIIFPGVGAAGSAMNNLRETGLDNTLKDLISMGKPMLGICLGCQIILDKSMENSATTLSILEGSCLRFDNELIDEHGDPINIPHMGWNSVNLVQECELFRDVPQEAEFYFVHSYYPTPRKDLVIGLTNYGLDFCSVFGRPGLWAMQFHPEKSGRPGLKILNNFYRYCRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMT9</accession>
    <name>D6SMT9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sucrose-phosphate synthase</fullName>
            <ecNumber evidence="3">2.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = H(+) + sucrose 6(F)-phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:22172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57723"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869128.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3442"/>
    <dbReference type="EnsemblBacteria" id="EFI36000">
        <property type="protein sequence ID" value="EFI36000"/>
        <property type="gene ID" value="Dthio_PD3442"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="485699at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046524">
        <property type="term" value="F:sucrose-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006380">
        <property type="entry name" value="SPP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044161">
        <property type="entry name" value="SPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012821">
        <property type="entry name" value="Sucrose_P_synth_Pase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012822">
        <property type="entry name" value="SucroseP_synth_GlycoTrfase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46039">
        <property type="entry name" value="PTHR46039"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05116">
        <property type="entry name" value="S6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02472">
        <property type="entry name" value="sucr_P_syn_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02471">
        <property type="entry name" value="sucr_syn_bact_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="6">
        <location>
            <begin position="36"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="254"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="S6PP" evidence="5">
        <location>
            <begin position="473"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="714" mass="81076" checksum="92D0C6CC0747A53A" modified="2010-08-10" version="1">MTNIRRRKDGLYLVHLSIHGLVRGFDMELGRDSDTGGQVKYVVELARALGKNPRVARMDLLTRKVLDSKVDNSYGKTIEKLGDKANIVRIECGPKRYLRKEVLWPYLDEFTDKALQYFRRVGMVPDIIHGHYADAGLAGSKLAQHLGVPLIFTGHSLGRIKKQSLLEHGRNEATIESRYNMSTRIEAEEVALGNASLVITSTAQERDEQYKEYENYHPRRMRIIPPGIDLDRFYPYKSDQKKPRIAHELDRFLQKSNKPMVLALSRPDERKNITTLVEAFGESPELREAANLVIIAGNREDIVRMDKGPKRVLTRILMLVDKYDLYGQAAYPKKHAADDVPELYRYAAQRRGVFINPAMTEPFGLTLIEAGATGLPLVATDDGGPREIIGKCANGTLIDPLDKEAMVNALLALVRDRENWKKHSRAGIKGVKKYFSWDAHTKTYLREIQKLRPRRKEEEPRLPIIKSKLPVAEKVLITDIDNTLLGDHEGVKDLLDILSSMQEELVFGVATGRSLESTLNILAKENVPVPDILITSVGSEIYYGPNILKDHAWSRHIAYRWKPGAIAEVMKEVPGVQMQAQENQREFKLSYNYTPGKYPGIRYVRRLLRQKDLHAKMIHSHNQFLDFLPVRASKGLAIRYLCMKWGVDMKKVLVAGDSGNDREMLLGSMLGVIVGNYSQELKNMPVTSNVYFASDYYARGIIEGMQYFGFLEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMZ1</accession>
    <name>D6SMZ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase central domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869180.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3495"/>
    <dbReference type="EnsemblBacteria" id="EFI36052">
        <property type="protein sequence ID" value="EFI36052"/>
        <property type="gene ID" value="Dthio_PD3495"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="279"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="527"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="737" mass="84554" checksum="B28A05D56E2447D3" modified="2010-08-10" version="1">MPKPRGKSRPKIKENSPEHVFRMDADDLFIRQKSAVFMRRVLELMKRIDEPAIEFIRWIIADSRQLEDLLLSKLRKHDRERILEQFSPRSHDMEAWKAVDFLVSALEATPPDHHGYVLHGVKNILDDFLSSHQSSACSIQENLNCLRETFRLSEHESEMILFIFLLGVQRPFSDYFDEHLDCQAYTGRKYLATALGIDSNQLREVLSGHLFELGLLRRKFNFLELDEDITRTLAQGNAHRLNSKYFIEVSRDYIPLKNHLLSEGTVEHILSLLKEKRESPTHILLYGPPGTGKTTFARAIADKINCPAYETVHPEDNSAHGLRKAVQACINITNEGSGSLMIVDEADSLLQAGASYFHWGEVKDKGWLNKFMEKPGVRALWITNRVDGIQESTKRRFAFSLGFKKFNRSKRIYLWNSVLNNNLAGQLVTEKEVQTLARDYDVSPGAMNMAALKSLEIAGNQEGFYASVRRSLDASKTLLHDGNICEPNESLQNDYSLEGLNIKADIEDFAGRMEMFSQALSRSGKSAGISTLFFGPPGTGKSELVRYLGRKLDRELLIKYPSDILDSYVGMNEQNIAGAFREADQEECILVFEEVDSFLSARSMAQRSWEVNMVNEFLARMERFRGLLICTTNNYSWVDRAALRRFMFKVEFDYLLPEGRQIFYRKVLSPLLEQEPTKEQMEQVKTISDLAPGDFRVVRDRFSLLPAPEVSHSELIQSLELEVKMKDKHRYGYRLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN37</accession>
    <name>D6SN37_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869223.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3546"/>
    <dbReference type="EnsemblBacteria" id="EFI36098">
        <property type="protein sequence ID" value="EFI36098"/>
        <property type="gene ID" value="Dthio_PD3546"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="153"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="332" mass="37942" checksum="FE98907CD5C5E3AE" modified="2010-08-10" version="1">MRGRNIVQLLRAVDLLSQPGGSTINRMSEALDIDRRSVYRLLDIIQALGFPVYDDIQEMGREKLWKMDADYVLKLPNITLPDVRLNLSEILALHLLRTEASIYAGTEIEARIEAAFSKLALFTPKDFQDRIGKLKTLFVSSGKLTKDYTGKEEIIDTLARAMLNQKTCVISYFSFVDETLKRFRVDPLHFFESSGGLYLFVRATRFGDIRILAVERIESLEELGDSFDYPGDFDPNAKLSMAFDMVYDDPMELEVVFSPGQAKYIRERRFSPSQEIIDNPDGSVTLKMSTSGWFDVKKWLLGFGAEAVVVRPVKLRDEMIEEMEAALERYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNE0</accession>
    <name>D6SNE0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869594.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1617"/>
    <dbReference type="EnsemblBacteria" id="EFI34266">
        <property type="protein sequence ID" value="EFI34266"/>
        <property type="gene ID" value="Dthio_PD1617"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="8">
        <location>
            <begin position="9"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="7">
        <location>
            <begin position="196"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="454" mass="52452" checksum="556A25207C4AB50E" modified="2010-08-10" version="1">MSLRMTTPPPHGGRLEERVVRDPQLAKKLAKGCPVYDIKPTLSDKGVPVRNVYREIMSTCYGFFSPVEGSMKEAEVEKVLNERRLLNNWIFPYPLVFDISEEDYKQLGVTAGDRVLLRLKGKPFAILDVEEVWRIKDTTELANRVFGSPEKNPEVVQEAFNEKHPGWVIYKSLNPVVLAGKYTIINEPKFRAPFDRFWCPPVKSREEFQKRGWRTVINHQTRNVPHVGHEHLMKNAAYTGDIEPCHGILVNAIIGVKRKGDYPDESILEGHEAVNQGGYIKPERHMVTYCLWDMRYGNPLESMLHGIIRQNMGCTHHMFGRDHAAVGDYYDQFATQTLWDKGIPSYGFDKSICEVEYGLHIKPQNMREFWYCPVCQEIAYSESCGHTKQKEKFSGSFIRGMVGEGIFPPRVIFRPEVYKAVVKWWKEFNFPFCNQNYVVAQEQKLEVDLPDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNF4</accession>
    <name>D6SNF4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1631"/>
    <dbReference type="EnsemblBacteria" id="EFI34280">
        <property type="protein sequence ID" value="EFI34280"/>
        <property type="gene ID" value="Dthio_PD1631"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="951" mass="104339" checksum="BE512A5BE1E98F18" modified="2010-08-10" version="1">MSRNSPAGSRKNRPRSMHGKVVSVLLLMLALLPVLVLGLYISLPFILERFLVSYMQDQGIQEAQIRVDSVGPRGIHLSDIRGENLGLEVDRVAVRLGWSSLMQGRADRIVVTGLNWRAGYTPEGLDLGLPFKGDDRERELAVPALPFDVLELQSSSFLMEYAGLGWRVPLSGVVQAGDVKNIRAEFETRLLGSALQIKGLADLESGRADVSIQSSWPEDERFESLPRQGLPLQAELSLTWAGGLDDPGDGCIDFYAELGRQHLTLAGTKFGLDRAALNLQGTFDGFSRDSLQAGVQLEGLKLGDFQFAGIDMLLKDRGVSSMQARLEKPDRLDLDLTGTHEDIFALWSGDEPWSGEWDLDLAGSVSPELAGVFLPKDALVQRDFPLQAAGRLKAWAIRDEGGLDWRVSLDSASAEAGPLDLHLPQQKAQVRGIFLELFPGISAGPDLTTVRLGRESRLGFDSMSMDLEDEHLEIPGITLSGRDDWAGLDLAAGEAPRIMLDASLPGGLVVKSRDARASFAAGGLQADLEFMDGLPRGGLTVSLSGGGVELQDMGLELAGISFGLPVSWDSQAQDRGRWNIEHIYYNGEKFPGPEGGVAVSDYRFQAYGAWEAFPGIKADLGLDLFFGDQGLKGRATAGTDWFDVPSREQLQDFFPRIRDFDIQGRARLDIQADLDAGGMEPYLQLELEDLDVQGREAGIAARGISGLVALDSIDPLYTARDRDSYLHVQELDTDIFSARDGLTSFRVRGDTLHLDKSSWLLVPQGRIAVHSSRWDLEAGEGRLDMYFEDVDLLEYAGRAFQDKIEGSGLFYGHVHLGLDSDRISLGDGYIYSLPGTGRLGIKDEELMDTLLMYVRQSLAGQEYLSILSERLEEALRDFEYDYFTLNIIPMADDVRARIEIRGEGVHGDPPQRVGSLVLNVSGLEDTLNHALDLGITGEDAARRALDDWLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNH5</accession>
    <name>D6SNH5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">Dthio_PD1652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869629.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1652"/>
    <dbReference type="EnsemblBacteria" id="EFI34301">
        <property type="protein sequence ID" value="EFI34301"/>
        <property type="gene ID" value="Dthio_PD1652"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="228"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="238"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="257"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="466" mass="51288" checksum="6C480FFC7FAD21C7" modified="2010-08-10" version="1">MPAQWEAHRTSGSTIAAIATPMGQGGVGIVRLSGPQSLDIAEKLFVPGPRFKGFKAYKLHYGWIKNRNQQILDEVLLAYMPAPYSYTREDVVEINCHGGPAVLEGVLEALYHLGAEPAAPGEFTKRAFLNNRMDLTQAEAALEMINAPTQDGALLARDKLQGHLKERVDSLRDSLEKLKQELCLAVDFPEEDLECLPLADLAQRTNSAVREIDQLLKAFEQNRVFREGALVVLAGRVNAGKSSLMNALLGRERAIVTSIPGTTRDYLEEAINLDGLPVRLVDTAGRRPTRDKIEMMGLETGRQLISRSDLCILVLDAGQEPAPEDLDILEEISPGKLVLAVNKQDLVSGTPGWVQDLKDKGLDLVHTSATLGHGLENLTRAIRSRILGEKRPQATSSLAPNLRQKTALDKARQELLLLADEARQEMPYDVLGVRLDYACTFLDEITGRIVTDDILNSIFENFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNW5</accession>
    <name>D6SNW5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869763.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1800"/>
    <dbReference type="EnsemblBacteria" id="EFI34441">
        <property type="protein sequence ID" value="EFI34441"/>
        <property type="gene ID" value="Dthio_PD1800"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105415at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="450" mass="52226" checksum="8974964256C48597" modified="2010-08-10" version="1">MQEQQFFEERLTKSVGQFDITGKTLLMPDMSPFGSRLLTSCFRAYGIPAQVMPTYDGLELGKEYTSGKECFPCQVTLGDILYYLKQEKERLGAEFSPGDYVYFMPEADGPCRFGMYNKMHRLVLDKFPEFEDVNITYLSSTDTYSSSMIMPEEKSKLFRRLAYVATIISDVLDRVVWRVRPYEKVPGETDAFMEGALQEMRDKIESIGESRDFNALYTLLEDIVKRASKLMDPDKPRRPLIGIIGEIYLRTHPQSNQHLIKEIETHGGEVVDASLGEWFNFVAYSNLRDTRRQWTQSWKKGDIQGMFNASRKWLDYQIEIKYQLWRQDQTFSRARKHLDIHEDHRIASLESRLDNDRLFNFDIGTEAAISIGGALEYVHENYDGVVNVFPFTCMPSTICSAILKPILLEKKVPYLDASYDGSIQPNRELAIRTFMYQAQQRQSRRNQAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP51</accession>
    <name>D6SP51_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869847.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1896"/>
    <dbReference type="EnsemblBacteria" id="EFI34527">
        <property type="protein sequence ID" value="EFI34527"/>
        <property type="gene ID" value="Dthio_PD1896"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1986697at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035652">
        <property type="entry name" value="CHP02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="123" mass="13721" checksum="414ADF19CB2EA8C4" modified="2010-08-10" version="1">MTNKRPPEITERAFQFAIRIVTLCQHLDEKPGVSRTLAKQLLRAGTSIGAILEEGRGSQSEADYLTKCSIACKEARETLYWLKLLAASEMLPANRLSAMTKECDELVAILTTIAKRLKEKRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPI4</accession>
    <name>D6SPI4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869980.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34660">
        <property type="protein sequence ID" value="EFI34660"/>
        <property type="gene ID" value="Dthio_PD2032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="68" mass="7618" checksum="1A47308361A66FB0" modified="2010-08-10" version="1">MPQEKTYLQKAMDNLYAALREQQSADPELRNRIQKSINTTQSALDLAKEREKGRAGAAGVDDDDPWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPI8</accession>
    <name>D6SPI8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH/Ubiquinone/plastoquinone (Complex I)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869984.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2036"/>
    <dbReference type="EnsemblBacteria" id="EFI34664">
        <property type="protein sequence ID" value="EFI34664"/>
        <property type="gene ID" value="Dthio_PD2036"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="122"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="486" mass="52309" checksum="B9E9F2B740EE44DA" modified="2010-08-10" version="1">MESLLVLVPLAAAMGSFLAPGRGIASWGFLTSLVIPALATGLALDVYHHGARRVSLGGWAEPLGIHLHMDGLSVIFLLMTALVGALVSIYSTFFFDRESARHFWPLWLLMWAGLNSLFMVSDVFNAYVVLELVTICAAALAVLSGKTESLQAGLRYLLVAMAGSLAFLMGVGFLYAETGMLDMFMQSGGLQGGPVTAAAFGLMTAGLIMKSALLPFHFWLPPAHGEAPAPVSALLSALVIKGSFFLLLRLWVGVFEPAGLTYHGAYVLGCLGVLAVLWGSYQALIQARLKLIIAYSSVAQVGYLFLMFPLLCTVPEAPWAEKAWAGGTYQAISHGLAKAALFLAAGNLILSTGTDRIHYMKNIASRLPMTTFTLGLAGISLMGLPPSGGFVAKWMFMQAILESGQWWWAVAPVLGGLLTAGYVFRILGHAFLLAEKEARMLPVPFVLEKIPLILALASILIGFRAEEVIFMLQEHMLWTVEWEDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPP1</accession>
    <name>D6SPP1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase AAA-2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870035.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2090"/>
    <dbReference type="EnsemblBacteria" id="EFI34717">
        <property type="protein sequence ID" value="EFI34717"/>
        <property type="gene ID" value="Dthio_PD2090"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="411"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="873" mass="97244" checksum="E30683AB5B2AC5A7" modified="2010-08-10" version="1">MLIDKFNLKSQELIESSSRLAVKKEHQHVTPWHLMSSLLNIGKNPTLTALQESGADLDKLGGRVSTSLLAQPKALASAQQTPISRDLERLFINAQEIAEKAEEKYIGINHILLAALEIQELAGALEEAGADREKLTLALQQVRSVDGPGQGKAPGDDFEYLAQYTKDLTESARQGELDPVIGREEEIRMASQILSRRLKNNPIIIGEPGVGKTAVVEGLAQRIVNGDVPESLQDVSILALDLGQLIAGAKYRGEFEERFKRVLQEITDAGNIITFIDEIHMLVGAGGSEGTMDAANLIKPALSRGDIRCVGATTSEEYRKHIEKDSALMRRFQTVTVEEPDHDKTLAILRGIKGKYETHHGIHISDSSLGASAKLSQRYISDRFLPDKAIDLMDQAGAALRISLASKPEDIDKIDQQIVELEIEAGALQGETDRLSMQRLEVVQNTLADLKEQSRTMTEAWEQQKEAAETLAKARKTLDDAKKELEQKVRQEDFSRVAELQYKIIPEAEQVLAEYENFDADQEPENGSPRALLPQDIAACVSRWTGIPVSKLMEEEKERWLQLEDYLRKRVVGQDQVLETISKAVRRSRAGVQDPNRPLGSFLMLGPTGVGKTEMAKALAEFLFDDERSLVRIDMSEFMEKHSVARLTGAPPGYVGYEEGGVLTNKIRRRPYSVVLFDEVEKAHPDAFNLFLQVLDDGRLTDGQGRTTHFYNTVILMTSNLGAETIEPAETEEEVQKMRSTLMDVVRGFFRPEFLNRLDDILICNPLTPEVMPPIVDIQLKRLNKLLADRGIEMDISDEAKHLLAQDGFNPLYGARPLKRAIQTSLQDPLAEMLIKEGMDEGGSINVDVEDGRLTIRKEESQHEEPDSAELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPP5</accession>
    <name>D6SPP5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870039.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2094"/>
    <dbReference type="EnsemblBacteria" id="EFI34721">
        <property type="protein sequence ID" value="EFI34721"/>
        <property type="gene ID" value="Dthio_PD2094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1230033at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="284" mass="33152" checksum="4DB93F99354439D5" modified="2010-08-10" version="1">MQDAALQRKLKQRIHEFDPLSLLLLLKHWGYNLDQIIFYSHADIVSQDSLFRSIDFYRHPRHYVKIEVNMGLLGSQSTLPSYFFKRMNQDNTDVGKFTDFMHFLDHPMLLTLFRSIYPEIDTRIFPDYEESKALQLQLLNIRSPASLHQFFQIAFPELVVKVDKTVLKREIKSRPFIVGRNSIGSNHFLGSTFKAHVQGIRVDLFSEEEFCNNGDAWVNVINRRLEQFIFPILKKAGAELEVYLVLLGEKQWARLHAGQLGYDVFKGGQTRARRMRVFSGNVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPW5</accession>
    <name>D6SPW5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylation/Crystallin J1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870107.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2168"/>
    <dbReference type="EnsemblBacteria" id="EFI34791">
        <property type="protein sequence ID" value="EFI34791"/>
        <property type="gene ID" value="Dthio_PD2168"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="268" mass="30082" checksum="395EAA632D08AD49" modified="2010-08-10" version="1">MIGAIAGDIVGSVYEWDNIKTKDFDLFSSRSFFTDDTVLTVALVDSILTGRPYDENMRRFYKWYPGVGYGGSFHKWAKNPGLGPYNSWGNGAAMRISPVGFAYDDLDTVLKKAREYTEVTHNHPEGIKGGQATAAAIFLDRQGKTRDEIKTYIENEFGYDLNRHVDEIRTTYQFDVSSQGTVPQAVRAFIDSSGFEDALRTAVSLGGDSDTLACITGGIAQAFYKGVPEDIQVRVYRILDDRLRDITEKFMQRYCSQKPPQNQADSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ08</accession>
    <name>D6SQ08_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870148.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2225"/>
    <dbReference type="EnsemblBacteria" id="EFI34834">
        <property type="protein sequence ID" value="EFI34834"/>
        <property type="gene ID" value="Dthio_PD2225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="11182" checksum="1A351C95DF913E1C" modified="2010-08-10" version="1">MEKKEEILFFLQEHRKELKERFSVRRIGLFGSVLNDAAETGSDVDILVELDQPTFDNYMDLKFFLEDAFGRSVDLVLADNLKPRLQPIISQEVTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ46</accession>
    <name>D6SQ46_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870186.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2263"/>
    <dbReference type="EnsemblBacteria" id="EFI34872">
        <property type="protein sequence ID" value="EFI34872"/>
        <property type="gene ID" value="Dthio_PD2263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="718091at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="228"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="455" mass="51932" checksum="4498F9A930040817" modified="2010-08-10" version="1">MAYKKTEKKYNETFREYISHWKGCIFTVTDDVLFYKTMVASFKYLGINTSALIYRRYIDSVSSDARALLSSGHFSRIIFLMENMVEGSSNIIRLRDLRSSFGDECRFITLTAETDSDNVAQMYEMGADNVIVKPVSINSIIQKISLTFKPNDALSQKFNQAKALILTNDLDQAGKVVEDILKEKPDSAAGFILKGDIAKAQNDFELAESYYVRASRESKMYLEPLKRLVNLYDAMADLEKKLEYLKKLDKISPLNYDRKIELGSTYLHLDDEENAVQNFNQAIRQVQKQARDIISSTMAKIARKIQGIRPELSTRYLEKAIEYKGKDLNRDDLWIFNEIGINLRQQGKLSRAIEYYQQALKIAPGDEGLYYNIGLAYAQGKQYYNALAHFQKAVELNPDLLTRYASIPYNMATTHAALKQNDEAARLAEKALAIEPGHKNARRLLKSLTPDSEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ52</accession>
    <name>D6SQ52_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870192.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2269"/>
    <dbReference type="EnsemblBacteria" id="EFI34878">
        <property type="protein sequence ID" value="EFI34878"/>
        <property type="gene ID" value="Dthio_PD2269"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370464at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038734">
        <property type="entry name" value="YhaN_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13514">
        <property type="entry name" value="AAA_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_27" evidence="2">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="483"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="601"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="663"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="729"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="799"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1167" mass="133504" checksum="7B67DAF1B3E70CBD" modified="2010-08-10" version="1">MKINTLKLKAYGHFTGTELQLEQNGGLQLIYGPNEAGKSTALRALTTLFYGFDHQTRDGFLHQNKDLAVGACLELDSGQQWEITRYKRRKNDLLDASNSPVPQEAVNRLMSGMSRDMFSAMFGISHDNLRAGGKEILRAQGHLGQALFSAAAGIMHLRRVREDLHKRADELFRPRASSTRIMQKKSSMAELGRELRQASIKPERWKNLQNELKQKLHQKQNTLSRLKQLEADLAWHSTCIRALPRIARRRDLLRQLGELEHVPRLEQDFSQRRVKAASSLENARQDRRDRQKELQDLEQELSELEIDSGLIRFAPRIRTLSGQVALIQQAMQELQDLEAEKITLEQTIQDKKAMLGSSVSCSDMDHLAPDRKHQSRIQELASEKSSLDQKASQARESMLEQARILRLCRRDLKKMPPLPDIELLDAVSKKLTSGEDLQDKIRKAGEKVQSLQLQIQAGISSLGLASLDSRSLPGLPLPLPESLERMQSLLDAKEKQLESARHKHQELNQELADRQAELERRQKEHALPLPRDLESRRKVRDQGWSLIKKSWLQGTQSPEEIHEYLHQTGGEDLASSFEQSISELDQTTDQMLDRAHHLARLKALHDEIQACSQKIDQASKDLDKAGADYQQACREWQALWSETGIEPLSPREMQAWLYRAQELIRQVQEKQQYQQALEEYEQELQSLCTQGAKALESAGYSAAQGHDPATLNRIIDKYRDRARDDLAAADLLRKEIRSAEKKLQKAGEQAGAVQEDLNTWRQNWIRALESLSLDPDSDIRTVQEEIQLRQDLFAACGRMRSLQQRKAGLEQKVREFESAVQGLVQELKRNPGRASPLEILEALALELDQEEKKQSRQEHLQQERRKIRTKLDQAEGRIQTLQRELEQLCREAGAEHPEELPALEEKAAMKQELRTELRQQEEQLQELAGGEDLEKFINDASARDMQELQALSTELAEEKEELEKKREEIISEHATLEKELQDLDGTSKAADISQQIQEQKSELEQEVQEYIQLRLAEAILSSEMERFRQANQGPVLEMAGKTLNRITLGSLTGIYADYDQRGEPVLKALRMDGTGLGVEEMSDGTRDQLFLALRLGGIRHYLDNNPPFPFIVDDILVHFDDERSAQTLQELALLSKQTQVLFFTHHTHLLHLARQHLDPARLQIHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQC2</accession>
    <name>D6SQC2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870262.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2340"/>
    <dbReference type="EnsemblBacteria" id="EFI34948">
        <property type="protein sequence ID" value="EFI34948"/>
        <property type="gene ID" value="Dthio_PD2340"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="DNA-binding region" evidence="2">
        <location>
            <begin position="53"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="156" mass="17086" checksum="8294DE495A209979" modified="2010-08-10" version="1">MAGSMNKAIIVGRLGQDPKLAYTANGQPVVNMSLATDESYTDRDGNKVDKAEWHRVVVFNKPAEFCANFLRKGSLALVEGKLQTRKWQDQQGQDRYTTEIVAMRVQGLDSKGQSQGGESYVAAPEQGRDQSQARESQEKMGPAFPSEAGGMDEAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQC4</accession>
    <name>D6SQC4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870264.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2342"/>
    <dbReference type="EnsemblBacteria" id="EFI34950">
        <property type="protein sequence ID" value="EFI34950"/>
        <property type="gene ID" value="Dthio_PD2342"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1342502at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="216" mass="24248" checksum="434FD63D63B6F120" modified="2010-08-10" version="1">MIDTISLLNEIKQAPYKEITVSAPHSGRIEFAVNQTGVKVKGASGTWLERPGTLLARLVREGNPKPIYAPEKGEVVEFYDVSDREFVQAGTPLMKIRHCLTKQEVMDIILKKALHLFIAPEKGRYYFVSEIDTKIKSQGLRSVSVKEGDEVLILSRMKRETTITYQGPQGIIYTAYFNSNESVETGAPLFGVCPENQVQDIKAVIDKIQSGWEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQF0</accession>
    <name>D6SQF0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HdrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870290.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2368"/>
    <dbReference type="EnsemblBacteria" id="EFI34976">
        <property type="protein sequence ID" value="EFI34976"/>
        <property type="gene ID" value="Dthio_PD2368"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="652" mass="70977" checksum="7C4AA94BEC223029" modified="2010-08-10" version="1">MKIGVFVCHCGSNIAGTVDTARVAKAAMEFPEVTFASDTMYACSEPGQDAIVEAIREKGLDGVVVASCTPRMHEPTFRRTVERAGLNRYMFEMANIREHVSWIGKDMEANTNKAIELTRIAAEKLRRNQPLYPKQFEINKRVLVVGGGVAGIQAALDCADGDREVVLVEKRSTIGGKMAKLDKTFPTVDCSSCILGPKMVDVAQHPKITLYAMSEVEEVGGYVGNFEVKIKKKPAYVNWDLCTGCGLCMEKCPAKKSTDYFNENLGKTTAINIPFPQAIPKKAVIDPDFCRQFTKGKCSVCAKLCPTKAIDFEQQEEFVTEQVGAIVAATGYDVFDISKYGEYGGGRLPDVITSLQYERLLSASGPTGGHVKRPSDGREPKTVVFVQCVGSRDKSVGRPYCSGFCCMYTAKQAILTKDHIPDSDSYVFYMDIRAPGKMYDEFTRRAMEEYGTQYVRGRVSMIYPKGDKYVVRGADTLLGTQVELEADLVVLAAGAEAAVGAPQLAEKLRISYDTYGFYMESHPKLRPVETNTAGVYLAGACQGPKDIPASVAQGSAAASKVLAMFAKDKLENDPVISMVDINRCIGCGKCIQVCPFGAVKEVDFRGQPKAEVIETVCQGCGICTATCPQGAIQLSHFTDNQILAEVNALCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQH6</accession>
    <name>D6SQH6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="9" type="ORF">Dthio_PD2394</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870316.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2394"/>
    <dbReference type="EnsemblBacteria" id="EFI35002">
        <property type="protein sequence ID" value="EFI35002"/>
        <property type="gene ID" value="Dthio_PD2394"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="8">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="48"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="356" mass="40705" checksum="9AD017A9B72630C1" modified="2010-08-10" version="1">MFAKLDELEQQYMQIETDLSDPEVFSNQEKYRKLSKSHSELGPIVSTYREYRRIVSEMEENRELARDRDPEIRELAQAELETLQEEKDRLEEDLKIQLVPSDPLDDKNIILEIRAGTGGEEAALFAADLFRMYFRYAEERSWKVEVLNMQETGTGGIKEVIASISGKKVYSRLKYESGVHRVQRVPETESQGRVHTSAVTVAILPEAEEVDVNIEPNDLRVDVFRASGPGGQSVNTTDSAVRITHIPTGLVVSCQDEKSQHKNRAKALKVLRSRLLQIMEEEQKREYDDNRRAQVGSGDRSERIRTYNFPQSRVTDHRINLTLYNLESVMQGHLDGIIDPLVQNFQAQALQEAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQM1</accession>
    <name>D6SQM1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870361.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2441"/>
    <dbReference type="EnsemblBacteria" id="EFI35047">
        <property type="protein sequence ID" value="EFI35047"/>
        <property type="gene ID" value="Dthio_PD2441"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000110">
        <property type="entry name" value="Ribosomal_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00717">
        <property type="entry name" value="rpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="294"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="381"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="468"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="582" mass="65349" checksum="6A80D97E7AD8F80D" modified="2010-08-10" version="1">MQNTNETTEPQENFETEVSFESALEDYLNADFGEVQEGSIVTGEVVKVEKDYVLVDVNFKSEGQIPVSEFQDAEGNLTVQEGDKVDVFVTQKDENEGAISLSREKARRVKLLDDLQDIMDNQTTIQGKIVKRIKGGYNVDLEGLEAFLPGSHVDLRPVPDMDALVGQEMDFRILKINRRRSNVIISRRVLLEEERENMRQELLDTIKEGQVVQGKVKNITEYGVFIDLGGLDGLLHITDMSWKRIRHPKEMVQLGDDLELKVLGFDSEEKKVSLGLKQLVSDPWENIGEKYPEGTRMTGKVTNLADYGAFVELDDGVEGLVHISEMSWTRKLRHPSQLVKSGDEVEVVVLGIDSDRKRISLGMKQVSPNPWDVVAEKYPEGTILEAPVKNITEFGLFIGIEDGIDGLIHVSDMSWTKKVRHPSELFKNGDMVRAKVLTVDKENEKFTLGIKQLTEDPWAEVPRHYPVGTTVTGKITNITDFGLFVEVEEGIEGLVHVSEMSRKKIKNPKEFFSEGQEIQAKVIHVSADERRLGLSIKQHLEEEEKKSAPADQRGKNGSAAPGSNLGDLIRQKLEEGDGDKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQM7</accession>
    <name>D6SQM7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870367.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2447"/>
    <dbReference type="EnsemblBacteria" id="EFI35053">
        <property type="protein sequence ID" value="EFI35053"/>
        <property type="gene ID" value="Dthio_PD2447"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="213184at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032523">
        <property type="entry name" value="CcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003567">
        <property type="entry name" value="Cyt_c_biogenesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43653">
        <property type="entry name" value="PTHR43653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16327">
        <property type="entry name" value="CcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01410">
        <property type="entry name" value="CCBIOGENESIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="4">
        <location>
            <begin position="93"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="CcmF_C" evidence="5">
        <location>
            <begin position="321"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="634" mass="70972" checksum="5420B739D17EADE0" modified="2010-08-10" version="1">MHYLGFFALLTSLIIMILLAAAAFAGLWRIRSTGEDIKIVPWLEKGQAAVTGLVTLSSLVLLWAFITRDFTYSYVYRNSDEFLPMHYQVSAFWAGQEGSLLFWLWVVVIMAGIWLLSPVYKSLARDTKAWFWGMMFIVQAFLLLMLTGPSNPFIVYDIQPMGGSGLNPLLQNVGMIFHPPMTFLGYAGFTIPACLALAGWLSGDQRSWIFQCRNWVLFAWVMLTGGAILLGGWWAYMELGWGGYWAWDPVENASLIPWLISTAFLHTAIVGKQRNVLHRSNLILISLSLLTCFFATYLVRSDVIESLHTFGGRGVGGPLVIFMLAGLALTLFVAMAGQKQKSAMDSLWSKQGLLIVVSWIFLALAVIVAMGTMWPVISNIWTESPMGLGPDFYNRVCLPLFTAMALVMCVCPWFNWRQGILDMQGLLAVVLVFAVSVAGLWIGGMRDFMPLIAASAGTAGMVSMIFYILSRRELRRSRKGWGLYLVHFGVAMIVLGVAFSGPYQEEIQVRLSQGESTEISGFEVTYSDFREEHDPGVSIYEARLDVTRDGKEVGTMLPQRTLHRNFDQPYSEVSTIFSLGKEVYSTIMGFDQELNVTFKISVSPLVNWIWIGSIILCLSIFLIMGRVRIRSPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQN7</accession>
    <name>D6SQN7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">Dthio_PD2457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870377.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2457"/>
    <dbReference type="EnsemblBacteria" id="EFI35063">
        <property type="protein sequence ID" value="EFI35063"/>
        <property type="gene ID" value="Dthio_PD2457"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1278103at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="196" mass="21411" checksum="A7A2F691D1648064" modified="2010-08-10" version="1">MRQASIHRKTLETDVELDLVLDAGEKQGVKVQTGVGFFDHMLTLMAHWAGFGLSVQCRGDLHVDAHHSLEDVGICLGQALAKALGDKKGINRVGQASVPLDEALCRCVLDISGRPYLVYHGEQILPAIVAGEEKDVYREFFKSLACNSAMNLHLCFNYGQNGHHLMEAAFKSLGLALRQAVALDRTELLSTKGVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQQ7</accession>
    <name>D6SQQ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870397.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2477"/>
    <dbReference type="EnsemblBacteria" id="EFI35083">
        <property type="protein sequence ID" value="EFI35083"/>
        <property type="gene ID" value="Dthio_PD2477"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZD3C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1911069at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="181" mass="21249" checksum="0CD285CD57FAB1F7" modified="2010-08-10" version="1">MVNLGLTREPDSCPILFARLGFALPAGEDTRGPLLRSWPVQQDRIWELFFPLQQDQDHAAWARDLAACLKGLGQSRWCVDTHGLVQIFNLPLEKSLSRWGELFWPHFRMDSVFVFATGNDDHMVREVLESWHRRETNICLRRHYDFTLQEINDPALDTPQKIKWSLFRRGLWNRLGLKSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQR0</accession>
    <name>D6SQR0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ORF">Dthio_PD2480</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870400.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2480"/>
    <dbReference type="EnsemblBacteria" id="EFI35086">
        <property type="protein sequence ID" value="EFI35086"/>
        <property type="gene ID" value="Dthio_PD2480"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="208"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="27"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="202"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI35086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="403" mass="44176" checksum="5BE9461B70711032" modified="2010-08-10" version="1">MSVSSIEEAIEDIRRGKMVILVDDEDRENEGDLTIAAEHITPEVINFMAKYGRGLICLALAPEWVDKLGLPMMAPKNTSRFETAFTVSIEAAQGVTTGISAYDRSTTILTAIKDNVVPEDIATPGHIFPLRAKKGGVLVRAGQTEGSMDLARLAGLKPAAVICEIMRDDGEMARMPDLIEFAGKHGIKICTIEDLIRYRSRFDSMVKRVAEADLPTDCGNFRAIAYENEVDDHTHVALVKGKLKKHEPVLVRVHSQCLTGDVFGSLRCDCGNQLKAAMRMVDQAGKGVILYMSQEGRGIGLANKIKAYALQDQGRDTVEANEELGFGPDLRNYGIGAQILVDLGITKMRLMTNNPKKIIGLEGFALEVVDRVSIEVPACEQNQCYLLTKKEKMGHILSISSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQW6</accession>
    <name>D6SQW6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 12">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD2537</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 12"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870456.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2537"/>
    <dbReference type="EnsemblBacteria" id="EFI35142">
        <property type="protein sequence ID" value="EFI35142"/>
        <property type="gene ID" value="Dthio_PD2537"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="677575at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="329" mass="36278" checksum="F689BC7FA7463BBA" modified="2010-08-10" version="1">MSSSNFYRGRRLRSSKAIRDMVRETDLLPRNLVQPFFVLESQDPKESRPIASMPGQSQLAPAALEEEVSRAVDLGLQSVILFGIPVHKDQKASQAYAQDGIIQQTVQRLKKRFPSLVVITDVCLCEYTDHGHCGLIQDKKVQNDPTLELLAKTALSHAQAGADIVAPSDMMDGRVQAIRDMLDNQGFKELPIMSYAVKYASAYYGPFREAAQSSPSFGDRKTYQMDPGNAREALREAEADIIQGADMLMVKPALPYLDIISALQSSFDLPVAAYQVSGEYSQIKAAAQLGWLDEKSVALESVTAIKRAGAEIILTYFAREILGWMAGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQZ2</accession>
    <name>D6SQZ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NLP/P60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2566"/>
    <dbReference type="EnsemblBacteria" id="EFI35168">
        <property type="protein sequence ID" value="EFI35168"/>
        <property type="gene ID" value="Dthio_PD2566"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025606">
        <property type="entry name" value="NLPC/P60_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027017">
        <property type="entry name" value="P60_peptidase_YkfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039439">
        <property type="entry name" value="SH3b1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026864">
        <property type="entry name" value="SH3b2-type_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12912">
        <property type="entry name" value="N_NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12913">
        <property type="entry name" value="SH3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12914">
        <property type="entry name" value="SH3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019015">
        <property type="entry name" value="P60_peptidase_YkfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088035" evidence="2">
        <location>
            <begin position="17"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="N_NLPC_P60" evidence="4">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="SH3_6" evidence="5">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SH3_7" evidence="6">
        <location>
            <begin position="200"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="297"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="444" mass="49958" checksum="88FCDE40E6A841C0" modified="2010-08-10" version="1">MNVLFFWLVLSMLVLASCAPRQEGMVRDLEVLPQSSAHYIPELTGELFSLEKQGELYRDFREAYFGPWTRSEPKFEAQEVFWGFDFIRNREVYKENYLPADPDWLGRMRQQSDVSGYPSRHKRAVTVDNADMRAMPSRSPVFLDPQSPGEGFPFDYLQNTLVPAGTPVLITHVTRDGDWALAETDYAAGWVRWSGLALVDDDFVQKFKSGPLAGFVQDQAPVYTAGGRHVFTGRVGMLLPQGESGALKDGQGIMVPVRDEHGQAALVEGKTRSGVLQKFPVPPTGDNFAGMMDSMLGQAYGWGGMYENRDCSALLQDLFRMYGIFLPRNSAQQKSFKEPISLEGLAREKKLEKIVEKGRPLLSILYMPGHVMLYLGKDPGSNKPVVYHSMWGLRTSRVWHSEPGRHIIGRTVITSLEPGRELRNLVRPEGLLINRVTHMTTVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR74</accession>
    <name>D6SR74_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan lytic exotransglycosylase</fullName>
            <ecNumber evidence="2">4.2.2.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Murein hydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870548.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0516"/>
    <dbReference type="EnsemblBacteria" id="EFI33190">
        <property type="protein sequence ID" value="EFI33190"/>
        <property type="gene ID" value="Dthio_PD0516"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1529555at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14485">
        <property type="entry name" value="mltA_like_LT_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026044">
        <property type="entry name" value="MltA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034654">
        <property type="entry name" value="MltA_3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005300">
        <property type="entry name" value="MltA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30124">
        <property type="entry name" value="PTHR30124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03562">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019422">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00925">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MltA" evidence="6">
        <location>
            <begin position="156"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="414" mass="47378" checksum="53E793944965E743" modified="2010-08-10" version="1">MPVFRKARDLFTGWLAGYPCWAVIPAFLVLFLWGCAPEEPVLEPEPVDIPPLFAPVDGREVVGIVQKDLQEQGLDSWEDLAPALEKSLDYVRTRDGDQKAVCQPELCLTWSDIKETLELFIQLLPDIDRNPELLKHYFDFYAVNPDVLLTGYYEPELKASREKHDDFRHPVYGRPDNLKSVDLGQFHPRWKDQRLYYRLENGEIKPYYSRGEIELEDALAGRDLEIAWVKDPIDLFFLHIQGSGRLKYPGGDYKHVLYADRNGHQYVALGRVLVDLGFLEQDEVSMQSIRAVLQENPDIKHELMAKNPSYIFFHLDDQGPRGSTGQILTPWVSVASDPEVIPWGSVMIMDAELPEYQGQKTHIQGPVTAQDTGGAIRGRHLDFFCGFGERAEYIAGKMSDRADIFFMVRKYGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR89</accession>
    <name>D6SR89_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar basal-body rod protein FlgF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0531"/>
    <dbReference type="EnsemblBacteria" id="EFI33205">
        <property type="protein sequence ID" value="EFI33205"/>
        <property type="gene ID" value="Dthio_PD0531"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012836">
        <property type="entry name" value="FlgF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02490">
        <property type="entry name" value="flgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="183"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="261" mass="28980" checksum="1C77977AD209A9EE" modified="2010-08-10" version="1">MQDEMYSAFFGAMSQEAKMNTITNNLANVNTTGYKRDKIAFEDVFTRYASDYGDPNMTLEDRLPWPESKLRSQTRPSPVHLDLQDGDMRKTGNPLDLAISGEGFFEVTTPEGETAYTRNGSFLRNPETGHLVTGQNFELQGEGGPIEIPEDASNIAIGENGEVLADGDLLDVINLTTFTDLNALEKKGRQLVQVKDGADSAPIPAEDARIEQGYLENSNVDPVYEMVNMISTMRNFEALQKMMTSSHEKDQQLIQQVGTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR96</accession>
    <name>D6SR96_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870570.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33212">
        <property type="protein sequence ID" value="EFI33212"/>
        <property type="gene ID" value="Dthio_PD0538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023971">
        <property type="entry name" value="CHP04081_GSU1558"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04081">
        <property type="entry name" value="selen_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="6471" checksum="303A332305EB2C3D" modified="2010-08-10" version="1">MDAKDAKTYLTSLCLAALLTGGGFAAPGPAFGMGQSGCSTNGAATDTNNGDDNDDDIDDEPDGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRH7</accession>
    <name>D6SRH7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver modulated serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870651.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0619"/>
    <dbReference type="EnsemblBacteria" id="EFI33293">
        <property type="protein sequence ID" value="EFI33293"/>
        <property type="gene ID" value="Dthio_PD0619"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="376" mass="42640" checksum="B5794B27C3A62D40" modified="2010-08-10" version="1">MKKVKLLIAEDSSINRKFLIRLLGDEFEIEESCDGEEAVDKFAAFAPDIVLLDIHMPVMDGLEVIRHIRNTSVDRDVFILVLTGEESTEVKVEALNQGANDFVLKPFVREELQARVRVAKRQVLILEELRKAYAVISTEMDMVADLQARLLPRDGFEFPGIDLDWMYLPSGRASGDYYDFFPVGPDTLRFVVADVSGHGARAAFIMNTVRAIFRMSWRNYFPLEQVVGFVNTDLCQIVGGEADFVTLLACDLNLGASSLSYINAGHCPGFFLADQEIMHEAQPNCRPLGIFPLDISAGEITFKESLKAFLYTDGFYEWELTPGEILGLDRFRSEVQQMILQDCFGLEALKERLKRIGNDRVWFRDDLTALWVRTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRZ3</accession>
    <name>D6SRZ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870811.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0793"/>
    <dbReference type="EnsemblBacteria" id="EFI33459">
        <property type="protein sequence ID" value="EFI33459"/>
        <property type="gene ID" value="Dthio_PD0793"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="391" mass="40996" checksum="B25A15C2EAC8FF9D" modified="2010-08-10" version="1">MGCLCAAGRDLPSCLAGIFSRDIAPAKPGRFHTDHLNIYPVFEVPRELFGQGNSSSENRHTLTVLYALSAVDEALTHAGWEARDLGRLKVGVCIGTTVGSTLNNEDYYREYLAGNQPDPKPVCRYLKNNPASVIAEKFGLDGPCQTVVNACSSGTDAIGVAAGWIQGGVCDLVITGGTDELCRVTYNGFASLKIMDVSPCRPFDISRNGLNLGEGAGIMILESPLLRKLDTKNVSGHILGYGSACDAHHLTAPHPEGAGLFRALTQALRLSEADLSQIAFVNAHGTGTKDNDRVEDMVLARVLPNIPFLSTKGYTGHTLGAAGGIEAVLTLGCLNLGRVPGSAGFSSADPESASSPVSERITVEGNLAISQSLAFGGSNAVLVLGKGQSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS15</accession>
    <name>D6SS15_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870833.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0815"/>
    <dbReference type="EnsemblBacteria" id="EFI33481">
        <property type="protein sequence ID" value="EFI33481"/>
        <property type="gene ID" value="Dthio_PD0815"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939079at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="213" mass="23347" checksum="37A27949155D52FC" modified="2010-08-10" version="1">MKTLIRMVSIVILSTVLLGCAFGNKHSYHDAIANINIENTIAVAVTAHDQRAYIVSGNKDPDFVGLQRGGYGNPFDVKTESGNSLADDMSKSLANSLVERGFEVQYISVSSNMDKDSVIDKLKEKGSDRLLVMTINEWKSDTYNNTALIYDMKVSILDGAGMQLASNSIKGRDNLGGSFINPAGHAKQVIPKAFTDKIELLINDKEIRNVLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS81</accession>
    <name>D6SS81_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870897.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0881"/>
    <dbReference type="EnsemblBacteria" id="EFI33547">
        <property type="protein sequence ID" value="EFI33547"/>
        <property type="gene ID" value="Dthio_PD0881"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2075502at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="15694" checksum="2A1DC36BB331FB60" modified="2010-08-10" version="1">MKYLGIDFGIKRVGLAVSDEKGKMVFPLKTIHRSTRENLFLELLNIIQERGIEAIVLGLPLGPDGEKSLTCRQAENFMQSLDRRTDLPIYTVNEAYTSMEAEDILNRCGIRVEKQKESLDQAAAVIILESFLAGIPLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSF6</accession>
    <name>D6SSF6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein Dthio_PD0957</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870972.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0957"/>
    <dbReference type="EnsemblBacteria" id="EFI33622">
        <property type="protein sequence ID" value="EFI33622"/>
        <property type="gene ID" value="Dthio_PD0957"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="310" mass="35066" checksum="BBE0B0BA0BADB8B8" modified="2010-08-10" version="1">METHKQGLIRDVPGREKEHAGCYPVIIVTGLSGAGKSTALNVFEDLGFFCVDGLPVTLAPTIMELFSRENPKNFRGLALGMDLRQSDFAREWSRVRDRMSQNRICLQIIYLEASSGVLVRRYAETRRPHPMEGEGIGLEQALEKEKQILEPLRSDAHLVVDTSDFSIHDLRRALKEKWECLDQVLAGIRVHIISFGFKYGMPSEADMVQDLRFLPNPFFEPELKSLSGRDTAIADYVLGKPPGSSYLEKYKDFLGFILPLFQKEGRYRLTMAFGCTGGRHRSVAVAENVADFLKKNGYLVSLEHRHFQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSG0</accession>
    <name>D6SSG0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870976.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0961"/>
    <dbReference type="EnsemblBacteria" id="EFI33626">
        <property type="protein sequence ID" value="EFI33626"/>
        <property type="gene ID" value="Dthio_PD0961"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034BQT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1972006at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="101" mass="11514" checksum="4ED6848A278E9C2D" modified="2010-08-10" version="1">MKLVHITFRFEYVDHVERILDDSGVEDYARYPMVEGKDQEGKHFGSQVFPGSVTVCQALVKNDLVEGLMQRLQEFRMKKGAHRHLRAAVVPVEQVLGTGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSK3</accession>
    <name>D6SSK3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871018.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1005"/>
    <dbReference type="EnsemblBacteria" id="EFI33669">
        <property type="protein sequence ID" value="EFI33669"/>
        <property type="gene ID" value="Dthio_PD1005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="194" mass="22657" checksum="DA8D0E5CFFF4BCFA" modified="2010-08-10" version="1">MRYKGINHIALATGDLNATIRFWRDLVGLRLIAGLGRPGYRQYFFEIGPRDMLLFFEWNHVQPIPEKDHGVPVQGPFGFDHLALEVETLEDMWQIYDRLKAADIWVSEILDHGFIYSLYSFDPNNIPIEFSWANPEFDLRKTPRMQDSKPVFEARKGPDPLPDVWPEVSEPTLPQEQKIYPGEGSELRSKKNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSM5</accession>
    <name>D6SSM5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871040.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1030"/>
    <dbReference type="EnsemblBacteria" id="EFI33691">
        <property type="protein sequence ID" value="EFI33691"/>
        <property type="gene ID" value="Dthio_PD1030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1296819at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="221" mass="25255" checksum="C978BCF1D05C40E3" modified="2010-08-10" version="1">MDFYAFVEGPLTWIAILVFLVGIVVKGIMYYNASKKTDKLIHKYFSWKWVFATYAKWLLPNNETFKKQPLYCLAVYLFHVCIILLPIFAYQHIVMWEMSRFGISWASLPAGLAKWMTLAVVIIGLALMVRRAIHPDLKLLSRPADYLLLVVTILPFLTGYLAAHATLGTTGFLAENMQLFHMLSGQLMLILIPFTKLSHSVLFFFSRGATAVEFGRRGYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSQ3</accession>
    <name>D6SSQ3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871068.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1058"/>
    <dbReference type="EnsemblBacteria" id="EFI33719">
        <property type="protein sequence ID" value="EFI33719"/>
        <property type="gene ID" value="Dthio_PD1058"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="302"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="438"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="672" mass="75872" checksum="40D2095AB285C187" modified="2010-08-10" version="1">MPRFRDLSLKHKIFLSTAGVVLLFSLSSALMARWILSGYMEQELKTRGVSIAQSIADHSIGHVLTRDRDQLVATIFDAAQLGERRHLVEYVVILDDEQNVLSHTFITPFPDDLRGVNPVQEEQDYSIRSLDKADMQVYDIAVPILEGIYQIGTVRLGLKKEHIEQVARTMNITFGGFTLAVLVVMFVLSYRISLYITRPMQKLTGMADQISRGDLELKTVNGLQPGRDEPCPAITGSYQPCWHVDRLLEAELGDRHLPGKPDYCRDCLADRDKSGDEVQQLADSFNQMVRSVKLYRKRVLESEHKYRSLFESGPVPVFVLDLETFEILDANSSAEKEYGYSRNELVGMEFTRLAPEFPEKLRTHLKQEPQDARIVYNKAIHYYRGNQPIYTNVEGRLSTYRNRDAVIVATTDITEMLEKDAQLIQASKMSDLGQLSAGVAHELNQPLNAIKMGSEFVQMMQQEGQDIPEEQLRQILGEINTQVDRATEIINNLREFGRKSDPGLEETDLNLCVQNVLTIIGQQIKLANIDLDFQPASQPVFIMAHKNRLEQVIFNLVTNARDAVMQKQAQQEPGWTGRIVIFTGISNGQAVLSVQDNGTGMPRSVVDKIFDPFFTTKEVGKGMGLGLSICYGIIQDYQGEIDIQSRENEGTTFRVFFSASDSHAQNSNPKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSW0</accession>
    <name>D6SSW0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thymidylate kinase</fullName>
            <ecNumber evidence="3 6">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tmk</name>
        <name evidence="8" type="ORF">Dthio_PD1115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3 6"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871125.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1115"/>
    <dbReference type="EnsemblBacteria" id="EFI33776">
        <property type="protein sequence ID" value="EFI33776"/>
        <property type="gene ID" value="Dthio_PD1115"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="7">
        <location>
            <begin position="5"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="24967" checksum="36391589E3F0981D" modified="2010-08-10" version="1">MFITFEGIEGCGKSTQTEFLRDYLEGLGYSVLVTLEPGGSRLGVELRRMLLSLESDDLTREAELFLYLADRAQHVHQVIRPALEAGRIVISDRFTHSTLAYQGYGREMGVDALQEMNIMAVDGTVPDITFLLDLPPETGLRRALGRNMEKNLTSSEGRFEAEALEFHVRVRQGYLELASRKKEKIVVLDAQALPETVFQGVVGKVNEIMKIDKKCVDNANCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSX8</accession>
    <name>D6SSX8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871143.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1133"/>
    <dbReference type="EnsemblBacteria" id="EFI33794">
        <property type="protein sequence ID" value="EFI33794"/>
        <property type="gene ID" value="Dthio_PD1133"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="180"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="423"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="101"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="546" mass="61471" checksum="CB7497E1A836907E" modified="2010-08-10" version="1">MQNSLNCLAIVCEASGRIREVLYNGLKDMENAAGDLFFHDILHQDSMQKAENFWKQLDEQGLALNWELNVQVNGEICTLDFTGVRVQDNMVITAGDSRDILNDLYQELLKVNNEQTNLIREAYKKYSTQAREQQFMEEGNTVLQEMTSLNNELTNAQRELARQIVRLEKLNSQKNFFLGMAAHDLRNPLGSIKLYAELLQEDMKHQLSETGAGMLDKIQSLSRFMLGMVEDLLDVTKIDSGQINLQLENVRPGRVVQDALDPLRMLAREKDISLNCHVLEDLPQVNLDVAKFTQMVTNLLTNAIKYSPSGSTVDVRLYTRDGYLVLDVSDYGQGIPGEEMDRLFAEYQTTSSRPTQGEGSVGLGLAIARRLVEAHDGTIEVQSSQGAGTTFTITLPMHLKSGHDALHKEKKTIEQKPLNFSGRILVAEDEPMNQTILARYLDKMGVEYKLVDNGQKVLQALQEDSFDLILLDIVMPEMSGVEVLQRLRTIEKEQGREKLPVVVMSALDHEEQENFLQAGADDLLPKPFNFQRLQRVLGSILSPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSZ1</accession>
    <name>D6SSZ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1146"/>
    <dbReference type="EnsemblBacteria" id="EFI33807">
        <property type="protein sequence ID" value="EFI33807"/>
        <property type="gene ID" value="Dthio_PD1146"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02522">
        <property type="entry name" value="GT_2_like_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026461">
        <property type="entry name" value="Trfase_2_rSAM/seldom_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04283">
        <property type="entry name" value="glyco_like_mftF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="32"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="254" mass="28160" checksum="6B0F2BEC8AB34715" modified="2010-08-10" version="1">MLWPKNQMLLSGRQDNPLETLPGKAVNKPDISVIIPVYREEQIINDFVQRLTEIFPAERHEIIIIDGDPVRTTLSALHVPGVSGSASGSGRGNQMNAGAAKARGKILLFLHADTTLPESAPDLIQTALRDQDLAGGAFSLGIDSSRWSLKLVEAAANLRSAATRVPYGDQAIFITKEKFSESGGFRDIPIMEDLELMTRLKKMGEKIIILPDKAMTSARRWKCEGVARGTLRNWLIRILYHLGVSPQKLCRMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST48</accession>
    <name>D6ST48_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871213.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1203"/>
    <dbReference type="EnsemblBacteria" id="EFI33864">
        <property type="protein sequence ID" value="EFI33864"/>
        <property type="gene ID" value="Dthio_PD1203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088294" evidence="7">
        <location>
            <begin position="34"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="125"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="393" mass="43554" checksum="A5987EB6CE0AA865" modified="2010-08-10" version="1">MKNTQSKLKISRNKFIKSAMGACSLCAAGIAVASSKVMAQTAPPEAEQPQTARMGFTSPREAAWFSSVEDSKIECALCPNGCRLKPGERSLCRVRENRDGKGYTLAHSNPALIQEDPVERKPFFHVLPGTRALSISTAGCNLSCKFCEVWDMALVDPEEVHAYDMPPEAVVKHAMDAGLKSLSYAFGEPVIFYEYMKKTAEKAREQGLLNLMHTAAYINSEPLQEICNSVDAVNVDLKSFDQEFYREVVGGELQPVLDSLKTIREKGLHLEITTIVIPTLNDDMEMINEMCRWIKNELGPDVPLHLARFYPLYQLSGLPRTPVSTLDQARETAMQAGLNHVYVSRVTGHEGENTFCPGCGEKIINRVGFVIDSMDIQEGKCSHCSREISGIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST85</accession>
    <name>D6ST85_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Flagellar biosynthetic protein FliQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fliQ</name>
        <name evidence="10" type="ORF">Dthio_PD1240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871250.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1240"/>
    <dbReference type="EnsemblBacteria" id="EFI33901">
        <property type="protein sequence ID" value="EFI33901"/>
        <property type="gene ID" value="Dthio_PD1240"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939288at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006305">
        <property type="entry name" value="FliQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01402">
        <property type="entry name" value="fliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="9905" checksum="A769AE342F07CB46" modified="2010-08-10" version="1">MTPEFVVGFARHAIETTLMISLPMLGIGMIVGITISILQAATQIQEMTLTIVPKIIAIFLALLFSFPWIMEKMVTFTTDLFNNIPNYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST96</accession>
    <name>D6ST96_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871261.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1251"/>
    <dbReference type="EnsemblBacteria" id="EFI33912">
        <property type="protein sequence ID" value="EFI33912"/>
        <property type="gene ID" value="Dthio_PD1251"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="944891at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="273" mass="30360" checksum="D3220A1ECE50D130" modified="2010-08-10" version="1">MIEPGQLVMLVSPKGKRYFRVLQTEDVLNTNDGQLQMQNVVHQGYGAVVHTHLGRAYTVLKPTLYDLIKSVKRRTQIIYPKDIGYIIIKLGIGPGCRVIEAGCGSGALTTALAWFVGDAGRVYSFERRQEFASLCRENLEKIGLESRVQIADGDIEQGFGIEKADALFLDVRTPWEYLEHIPGALIPGAPVGFLLPTVNQVSSLLSAMQDGSFSSVEVLEILVRRYKPVPERLRPEDRMVAHTGYLIFARLGAPGQDDTEPGEFTFHQEKEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6STB1</accession>
    <name>D6STB1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="8" type="ORF">Dthio_PD1266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1266"/>
    <dbReference type="EnsemblBacteria" id="EFI33927">
        <property type="protein sequence ID" value="EFI33927"/>
        <property type="gene ID" value="Dthio_PD1266"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="391"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="552" mass="62340" checksum="CC99EA9F286DC064" modified="2010-08-10" version="1">MTLTLKPTRRRLLIAHKPFGNLTGLKPHQLKALSRLYFRKFPASSGFTTEQARELASLTHQTKRQIGLIIDRRGHVLMVIVGDQGGILIPALDRLRESSGRLRGVRLLHTHMGSTCLTDEDLMDMVFLRLDSISVITVDPQGFPDQFQWAHLMPPNRERTPYRIYPSLHWSRAGADHQASVESLEKELGREGTAQEVSAEGNALLVSVDTRPRQEQERSLQEVAALAGTAGLEVSDTLIQRVHRVNPKSIMGKGKVAELEVMALQSNASVIIFDQELSPTQLRNLTSITDRKVIDRTQLILDIFAQRATSRAGKLQVEMAQLKYTLPRLIQQDRALSRLAGGIGGRGPGETKLELDRRKIRDRITRIKDELQKLRRHRENIRARRVETDVPVISLVGYTNAGKSTLLNTLTRSRILAEDKLFATLDPTSRRLRFPDEREVVLTDTVGFIKDLPEDLREAFMATLEELSLARVLVHVADASHPEVEEQVEAVQGLLRLLELEDKPLVMVLNKWDLVTQDRKEILQNVFRDAIPASAQEEETLTPLVQTLERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6STR5</accession>
    <name>D6STR5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage transcriptional regulator, AlpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871430.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1421"/>
    <dbReference type="EnsemblBacteria" id="EFI34081">
        <property type="protein sequence ID" value="EFI34081"/>
        <property type="gene ID" value="Dthio_PD1421"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010260">
        <property type="entry name" value="AlpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05930">
        <property type="entry name" value="Phage_AlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="7324" checksum="F608B579FB9EF2AF" modified="2010-08-10" version="1">MDNQTEKLLRLRDVLDRIPVSKSTWWDGVKKGRFPKPIKLGPRTTCWKESDIDDLINKGWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6STV9</accession>
    <name>D6STV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c class I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD1467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871474.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1467"/>
    <dbReference type="EnsemblBacteria" id="EFI34125">
        <property type="protein sequence ID" value="EFI34125"/>
        <property type="gene ID" value="Dthio_PD1467"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="101969at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="354"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="886" mass="100663" checksum="BEA0FCB5B330254B" modified="2010-08-10" version="1">MNYPVWELFTFSGGFWIATIAIVHVFVAHFAIGGGLFLVLTEMKGYRENNPGILEYTKKHAKFFMLLTLVFGAVTGVGIWFAISLVSPGATSMLIHTFVYFWAIEWVFFMAEIIAIFVYYYTFGSMERRKHLLMGWLYFIFAWLSLFVINGIIAFMLSPGQWLETGNVWHAFFNPTFWPALFFRTFIALMLAGLYGFVTASWIRDADLREQMIRYCAKWLLAPFVFMLISGYWYLQSVPEGAQAMILGRSPEIVPFFQAFIWLSVVIVIGGLIISIRMPGSIKRPITIIFLMIGLLYMGSFEWIREAGRRPHVIYEHMYSSSIPVEMEQEINEKGMLKMARWTEHDQVTSENKLEAGRDLYNIQCSACHSRGGFMNDIIPVTEKFGQFGMDSMLDGMGHVYDYMPRFMGTREERQALAAFIVQEIQGKEPEKPRTVDVPEFDFDIPPFDPDEDEYVLMAWNTLGLKCITDCDDYWSMLPPGNTIFAQLVRRDFMPEIVTQGVELTFRPEEGFENPANHVSYWDNSQSLAGRELPENISAKGLGMQGEMTLNEDLWTFVADGIPVVPYSDDGSINPYPFFYIEARDKDSGELLAETKVVAPVSAEMGCNNCHGGDWRVDGKMGIAAETASDVLKNHDRRHDTSLMPRAEAGEPVLCQSCHADPLLNAPGDPDILNLPAALHGFHVHYLSDREGAEACNACHPSDPDLYTDCKRGVHATRVDLDCTSCHGTLEDHALTLLKGEYEAGKTKQASRHMSLIEPRLVDSTEEINPRIPWEQQPDCLTCHQDFQQPESDQVSAFNVWNEEVDELYRMRTDYMGLMCQSCHGATHAEYPAENKFGQDRDNVQPLQYQGEPYAIGANNNCSVCHTMEMDYEAHHPNMLSGTRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6STW5</accession>
    <name>D6STW5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 16">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Dthio_PD1473</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 16"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871480.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1473"/>
    <dbReference type="EnsemblBacteria" id="EFI34131">
        <property type="protein sequence ID" value="EFI34131"/>
        <property type="gene ID" value="Dthio_PD1473"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1464088at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 16" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="18">
        <location>
            <begin position="353"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFI34131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="432" mass="46138" checksum="7016851AC701D624" modified="2010-08-10" version="1">MKKKVINLGLAGFGTVGTGLARIIQENSDWINRRLGKELKIQKVLVRDPGKKRSVIPGPETAIVTDPQDLVHDPQVDMVVELMGGLETAHSLIKSALKEKKHVVTANKALLAEKGNELFALAQEQGVGLYYEASVAGGIPIVQTLKESLSGDRIRSLTGILNGTANFILSEMTRKGQDFETALQAAKDLGYAEADPSLDIDGLDAAHKLVLLIRLAYGVDYPLNILPVQGISGASSMDIAMAAEFGCTLKLIAQVREKSGHLQAGVFPALLPNDHILAKVEGPYNSILIDGNAVGQVMLYGQGAGDLPTGSAVLADILALARDNAVPNNTGFLEKVLPRAEVIRPELAVSRHYFRFTAQDKPGVLAAVAGVMSEHNISIAQVVQRESQPQGGGVPIVFLTHKAQAEAVHKALGEIDRFDFTIAPAVHYRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6STX5</accession>
    <name>D6STX5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871490.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1483"/>
    <dbReference type="EnsemblBacteria" id="EFI34141">
        <property type="protein sequence ID" value="EFI34141"/>
        <property type="gene ID" value="Dthio_PD1483"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1414293at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024271">
        <property type="entry name" value="DUF3782"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012431">
        <property type="entry name" value="PDDEXK_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12644">
        <property type="entry name" value="DUF3782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07788">
        <property type="entry name" value="PDDEXK_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="20861" checksum="A9D84CAB0088E53C" modified="2010-08-10" version="1">MDIPESERRRAESRAESERKWEQHNRKWEENQKVIYQMLADIKKHLDKHDSSISCQWGPHKEQSFRNALKAILEESFGVKVLNVTEYDDAGEVFGRPDQVELDVIIFNQTLILCEIKSSISKADVHFFDRKATFYEKHHNRKATRRMVISPMVDPSAMELAKKLGIEVYSHSYDVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STZ2</accession>
    <name>D6STZ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871505.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1501"/>
    <dbReference type="EnsemblBacteria" id="EFI34158">
        <property type="protein sequence ID" value="EFI34158"/>
        <property type="gene ID" value="Dthio_PD1501"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10603" checksum="F6F9522E9FDDE60B" modified="2010-08-10" version="1">MSATMKINARGQIKIPKNIMQSLNIGPGDYIEIDLESGKAIMKPRKLIDPSQSWYWTPDWQVTEVKVDEEVDNNQVSQTFYSAEEGLKWLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU09</accession>
    <name>D6SU09_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871792.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0415"/>
    <dbReference type="EnsemblBacteria" id="EFI33100">
        <property type="protein sequence ID" value="EFI33100"/>
        <property type="gene ID" value="Dthio_PD0415"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033N6E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8027" checksum="909A4D6606C0659C" modified="2010-08-10" version="1">MGAVIRTLVDDFQGLPLEDQEYVAELIQKQLIESRREYLAKRVSEAKANYRSGQCKSGSFKELMEDIESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU54</accession>
    <name>D6SU54_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871530.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0141"/>
    <dbReference type="EnsemblBacteria" id="EFI32834">
        <property type="protein sequence ID" value="EFI32834"/>
        <property type="gene ID" value="Dthio_PD0141"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="304"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="1627"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1561"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1561"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1585"/>
            <end position="1603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI32834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1943" mass="222045" checksum="7AD2EF653C651F00" modified="2010-08-10" version="1">MFTEQSSPDRNFMVRTALVSAGQAIRINDWTYVTKKLLEVKSIYSEQPPANIYVLLSMAYRFQHLLDWAENIINEGKEKYPQHADILMEHAEVGKAQKDLISTDRYNKTLKQKSQKNTSQYRSAQHQIEKISKKLFELGFADRASGELKHIATGNYQNIVKTLAAWELASWYAGQLSRSNAQKCLDMLAVVEKSGADPAKFASASIIKAECLSLLGKDHEAKKFLQHALSQEPRTDLYMAAANLEPKLPDKLAWINKALRLHGLSEVSSTPDTGNNNAPASKRLRACSAAKLKAEQAHSSPLVSVIIPAHHNLHHINIALESLLKQTWENMEILVVGAGGQDDLEQKLSENIRQDSRLKIIWTNENAGKYLALNTALKKASGEFVTCHEPQEWSHPQRIETQVVSLINYPNSVGNIAQTTIIDADFKFVLQTNPGGYLTDNLSSFMFRREPVFNAVGYWDCVLYGADREYMQRIKNVFGGSSIFSTNSGILSFMNKTIDPHESQIKRNFTYFSGAISEYLESSNYHQSNTNCNHYEFPQNKRPFPAPHCLLPNTEDKLNDCRHFDVIIASEFRVPGGNNYSNLEEIKAQKLMGLKTGLIQISRYDLNYDHKKFPEFREYIDGEKVQVITCEERVSCDLLILRYPPVLQDLQKSIPNVQAKQVKIMANVPPLHYYGQKGLLRYKIESCHQNLLKYFNNPGTWHPIGPLVRKALTDYHADDLTYINLSKKDWVNIINVSEWKRASRPETGTNIRIGRHSRDHETKWPADKNELLSIYPDSDRHEVHILGGANTPKRILGYKPKNWIVHDYGSMHPQAFLSKLDVYIYYTNPNWVEAFGRVIIEAMAVGVPVILPHEYKSLFGDVAIYAHPSEVAARIDELMQDSDYYDRKVQRALEYVEENFGYSQHAKRLKEINPGFNIDFPGHYEPVQPDDETVAHALEAIQQENWAEAIRRWQKVFLKHKNQAPAHAYASLSLAHRMQGNPDKAEKLIEQGQKNYPDDKELLLEYVKTAKARRDRAEAAKRSQRLEQVSNRQEGLDHSSGTTYYQQAITSPIDNQHADPSTSQKMFSAKQRQGQSIGRNAKCPCGSGKKVKKCCGIESETKTQINKDDCSNHHASKLNNKENYNWCKPLQNYKSASVATDSEPLELDGKLKHIYFVYPDTKDAHGMHYNSSLKRVHKTKSAGIDAEAVALESPDFLRAITDCSNHEGYVLFAGRNGYDLTINSRKLNKNVFDHLNVNVIATLADHPYSSFMWRLLDNAAENTVFFTRPSLDRELRAIYPQLTRTDVYESLGGPHNQNIDQALAQRPLSKRHIDLLIPLGLHKFFKKPSLKQQLHQLGQEAQKIGESLFEAARKDYHTTVFENFQNIIKHEFGEEHVFSHPKTKQDWIWLNVLSVVDWTVRMDRRVRLLNSLHRLPSSTRINITASPKVADFFPRLKNKKNIHWIGEVSTKKLEDLYSESKMVLNCNPTYPDFVNERVRNAMAWGCCVISDYQQALGKHFQDHVSILFTDPEGRKIEDFCELNVNVLQDIADAGRNLMPAPQPDKGNIGFLKRIEKHLPDIKLNDPGQLSKDPDKSADPEAKALRSCFSSQSNSQKPASSKNNNLKLLMAGNQEVIENDQMTVDWILTRRCNYSCSYCTVYNNKTGFFVPIENLNSVIDRLNDLPHQKIKLALSGGEPTIHPRYLDFIEHTISTLQDRVTINTQTNFSRQLKFYENLVDRIGEQTDKISFSSSYHFEHAEKHRFIENILFLTEKKVPVTFKICAEPDRMDQVKDLYNEAKYLENDFLKVALVVVRENYGSFPDKRYSSEDLAWLQNEYTENKGTILLKYYDISCNRIRDYYHTADELIINGMHKFTGMSCYAGLNRISIGSDGSLAPSVCLRWSKGLKHNVYDNPSSILSFQEPITCPCKVCHVPADMQVPKYNFGLINKISKHNNQHLFSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU90</accession>
    <name>D6SU90_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HicB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871564.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0179"/>
    <dbReference type="EnsemblBacteria" id="EFI32870">
        <property type="protein sequence ID" value="EFI32870"/>
        <property type="gene ID" value="Dthio_PD0179"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="13059" checksum="7FBF85DA78B74506" modified="2010-08-10" version="1">MEKHDRFDGFSVSVFLDDDGEYIAHFLEMPNISAFAETPELALHELEVAWEGVKESYQKNGEPIPVAPARKEYTGRFNIRIDRRLHRALAIEAAKAGISLNAIVAQKLARETPQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUB8</accession>
    <name>D6SUB8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SufBD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871591.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0212"/>
    <dbReference type="EnsemblBacteria" id="EFI32898">
        <property type="protein sequence ID" value="EFI32898"/>
        <property type="gene ID" value="Dthio_PD0212"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="393" mass="42999" checksum="1EA83FDC3BD206D8" modified="2010-08-10" version="1">MSQLNESETPRVDLGRYSFDQQEQPALKDLRQLSEADRKQLLMAGVDTSEAQRSGSYLHVNHSKVHCSSCQKGVEILDIKEALDKYDGLPEYYWQAVDKDKDEFTRAAAEKVHGGYFIRTEKGAKITDPVQSCLFIKGENVGQNVHNIIIVEEDSELHVITGCTTSADVTSALHLGISEIYIKKGGKLTFTMVHNWGSEVMVRPRTVAIVQEDGVFASNYILLRPVRSVQSFPAVFLNGERAVASFNSILVAPKGSYIDSGNKIVLNAPDTRGEIISRTITTGGTIIAPGIIEGNTAPAKGHLECKGLVLSEGIIHAIPELKATVPGVELSHEAAVGKIAQEEIEYLMARGLDEEQATSTIVRGFMNVDIMGLPAELQASIEEIIDETEKDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUG7</accession>
    <name>D6SUG7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871640.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0261"/>
    <dbReference type="EnsemblBacteria" id="EFI32947">
        <property type="protein sequence ID" value="EFI32947"/>
        <property type="gene ID" value="Dthio_PD0261"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI32947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9710" checksum="1E5FCC730495A0D2" modified="2010-08-10" version="1">MSRVIIREERCKGCLLCTLVCPVDMLEQADRPNRQGYKVIRVKNQDMSVCKGCGFCAEICPDEVFVVYRSKKDRAGAENLEEEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUG8</accession>
    <name>D6SUG8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queA</name>
        <name evidence="6" type="ORF">Dthio_PD0262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871641.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0262"/>
    <dbReference type="EnsemblBacteria" id="EFI32948">
        <property type="protein sequence ID" value="EFI32948"/>
        <property type="gene ID" value="Dthio_PD0262"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="360" mass="41092" checksum="21A26EA55D9F7720" modified="2010-08-10" version="1">MSISEDFDLENYDYELDPARIASWPTPDRSESRLLMLDRQGGELQEDRFENIDQHLEPGSLLVVNNSKVLPARLMGHKESSGSVEFLLLTPLPLISPAMENREKKARVECLVRASRRPRPGDWVYFAENVRFRLVQDLDQGRAKGDLFWTGDLGDFFVRYGHVPLPPYIKRQDEPQDVNRYQTVYAHPDKQGSVAAPTAGMHFTPKLCHRLEDLGCMWAEVCLYVGYGTFSPVKSADIRQHVMHPEYIEVGSQAAESIRAARAQGRKVVAVGTTTVRTLESVCRMKGRVEPFTGWSDLYIYPGFKFEAVDQLITNFHLPKSSLLIMVSAFAGRRKILHSYQYAREKGFRFFSYGDAMFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUH0</accession>
    <name>D6SUH0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871643.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0264"/>
    <dbReference type="EnsemblBacteria" id="EFI32950">
        <property type="protein sequence ID" value="EFI32950"/>
        <property type="gene ID" value="Dthio_PD0264"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1094814at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="138"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="38444" checksum="AE9E1F1921D41B31" modified="2010-08-10" version="1">MSSKQIDAESLNEEFYQVTPDILESFPKFRLPLNLYRFKEDIGQLQPYYYADRRLDQNMQKDLHNYSRKGQIFVARSDHKIYAKHISKQLDLVLQDRNLTTEEVVYIIRFALTEKASDFFEQPVPAAMEKLKKDSLVLTQYLWEDRSRLENLLKMLHQEYSWARLCYNSTILGLALFMKMQEDSLKRRAMDNLALGLLTHMLGMTKVPAFILEKKTRLSREEQDKITNYPMTGANIMRKLDVLEDVALNCHLEHKELLDGSGVPRGLKGAEISLHGRLAALVHAFCEYSLRPDAKGQDLSRVAECLAQAQNKYDAKLSSSLQELVPQVQVAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUQ7</accession>
    <name>D6SUQ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871730.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0351"/>
    <dbReference type="EnsemblBacteria" id="EFI33037">
        <property type="protein sequence ID" value="EFI33037"/>
        <property type="gene ID" value="Dthio_PD0351"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="550" mass="63241" checksum="250E5A5BDE783E8B" modified="2010-08-10" version="1">MDIRAIAHLGRFREIVTTLVKYGFDDVVDRLDVPGRKYLEKIRVHTMHLTRWERMRMVLEELGPTFIKCGQILSQRADLLPRELLEELRKLQDDVPAEEFSEIRKVLQDNFAQPLEDIFSEIEETPIAAASLAQVHKAWLKGSNQEVALKIQRPDIAETIKSDMDILERIAIRLDGRMESFKVYNLPQLVQRIRKLMLQELNFAQEMRNMQVVRTHTLPEEKILIPEVYPELCGELVITMELSRGSKMKDVRVSELKNRASLAKRGLNFSIRQVLEQGFFHADPHPGNILIDEDENMILLDWGMVGRLTNKVRYELIDLIGAVVDNDVEEVTEILISFTTGRENVNRGMLQNEVLEVVSHFTRLPLKEVNLGQLLMELTTLLRNHGRILTTDLSIMIKALVTAEGTARMLYPDLDVIKEAEPMVRRMSKNRFSPSNLLKGLQKNIRYLMRFQYELPRQTMDIISKLDRGELAIRFQHQNLEGLQSTLERVVNRLVVGIVTGALFLGSGMIIMADTGPRLWGYPALGVVGYIIAVFLSLRLVMAMVRSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUT7</accession>
    <name>D6SUT7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871760.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0381"/>
    <dbReference type="EnsemblBacteria" id="EFI33067">
        <property type="protein sequence ID" value="EFI33067"/>
        <property type="gene ID" value="Dthio_PD0381"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="791672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="187"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="489" mass="55647" checksum="EBA5B0D6B588E6B2" modified="2010-08-10" version="1">MSRYDEIYKLLSNIYSEHESRRLGALTFLQTQTMLLWKLQAEKKKYPGFTRLHQNIFPQEKRREPREKESTAKLINKYMADFAAGPGPSDSDRELFNLVLQHAPYQEADAEVWERIIKFLNGYSLKDLFDASGQDARSDYCRAFNLKGYSIEDLFDASGQDTRSDYCRAFQKIIAEYGDPARVASLPVDLSLFMSRVLNIQDKDRVFFAGCGVGTALLNCVANEPANYVYAQDSIITNALSARVHLALFGCDHSKVPAKNLLLEPDFIEEDKNLKKFDCVISLPQMGSVSSRIAARLRKDPFGRFPETLVGRRFTLELAHMAHTLHAMKPSAGRGAILLPARFLSIESSHLIRAHIVSVNYVDAVITIPRSYIPSLTFDMAVLVLKMDKQDENVLFVDNSSFKLDPDYLMDILQKRQDGYKGSMLVTTTKIHGNKYNLYPGRYRKDTRTSRPDLEQIKERIISIDTELKDVQDKLDRELAEVGMLSGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUW1</accession>
    <name>D6SUW1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0406"/>
    <dbReference type="EnsemblBacteria" id="EFI33091">
        <property type="protein sequence ID" value="EFI33091"/>
        <property type="gene ID" value="Dthio_PD0406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="55" mass="6670" checksum="B8D798410CE0C274" modified="2010-08-10" version="1">MDTWISFFAKVVPMSHTKTMIYSLEITLPLREPRFDIKQIDICIQMYILRSRRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV24</accession>
    <name>D6SV24_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871870.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0075"/>
    <dbReference type="EnsemblBacteria" id="EFI32780">
        <property type="protein sequence ID" value="EFI32780"/>
        <property type="gene ID" value="Dthio_PD0075"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2079143at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="67" mass="7882" checksum="8C9BCC08A215E9F8" modified="2010-08-10" version="1">MKAYEYIAEVSPDGHISVPEDLKEKLAQNPKVRVMLLFEDEENSWNEFTRSEFLKGYSHKDSVYDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV55</accession>
    <name>D6SV55_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32811">
        <property type="protein sequence ID" value="EFI32811"/>
        <property type="gene ID" value="Dthio_PD0113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="276" mass="32798" checksum="73E63D81CB715467" modified="2010-08-10" version="1">MVIDRKRIEELKKEGFAQGAEEIKEKYIESGNRDGRIEALQDMLVESMKYQFNEVDKNINQKIRYIKNKLFLREMIQLSYETKNIEVINSSIHDHLSDEDMYRREGYEYAINHPNGFYQSGRFKGLINEKLSMIFSIFKKRFGHLEIEIEAAIMTMDLDERIEDLFLMTFKLYDKKELVRYLKKTMTGANVIKAGAFLVVYKSVRLNYLIDILFETKDCSIQEKIEKVRDLGEINFLIEKAKYSECLEDFIKELDQAVERAVDHRHEFSLDHLLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJQ7</accession>
    <name>D6SJQ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869235.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3562"/>
    <dbReference type="EnsemblBacteria" id="EFI36110">
        <property type="protein sequence ID" value="EFI36110"/>
        <property type="gene ID" value="Dthio_PD3562"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="96876at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128234" checksum="DA871357D795B3AA" modified="2010-08-10" version="1">MLNRQVYFKDPSTWSLVNQGVAKVDEDTTPDALKVLRYEMETFVCDGQYEKGLEQILHSYLRNIDQGAPEQPGVWISGFFGCGKSHLVKILKSLWTDTVFPDGATARGIARLPDSIRTHLKELNVQGKRQGGLHAASGTLGAGARGSVRLALLRIIFKSVGLPPKYPVASFVIWLKREGIYDQVRSIVEEEGHNWDEELDNFYVAEGLHQALTRVKPHHFPSPSSCVETLINLFPNVEDISNDDMLKTISKALTREKKFPLTLVVLDEIQQFIGDSSQRSMEVQEVVESCCKGIGGKLLFIGTGQTAITGTTNLKKLEGRFTIRVELSDADVETVIRQTVLAKDSNAIPVIEQAMHKNLGEISRHLSGTAIGHMHEDIDALTKDYPILPVRRRFWENTLRVLDQTGTDSQLRNQLSMIHKAIQTNLDHPLGNVIPADYLFFDAAERLLQARILPRKVHEKIMRWHSGNDDERLTARACGLIFLLNKLTAANQALGIKSEPDTLADLLVEDIAQGSGGLRSRLPGLLDDCSLLMKVGQEYRIQTEESAAWNDEFQNQFHQLANETHRVEAEREDRIRRKFGEITGRLSLLHGSSKVARNIHPVFEPSLPADCAQRICLWIRHGWETDENSIRAEAREAGNKSPTIFVFIPKRSADDLRRNLLSCKAAAATLDKRGNPGTSEGIEARAAIKTIMDNSEIRINELLDDAFSGARVFQAGGTEILGGNLQEMIIEAAENSLKRLYPQFDLADHTGWEKVYSNAGKGSPDALKAVGFEGEPATNPVCKAILGYIAGGKRGAEIRNRFESPEYGWPRDAVDGGLQVLLVAGLVRAEDERGNTVHPRELERKAIGKAVFKVESATVTTPQRIQIRKLFQKMGISSKPGEELSHVPEFLQKLSELASSAGGEPPMPEPPDTSFLEDIRLSSGNEQLLAIYNLRDELSRHIDTWSDLSQGISRRMPQWRVLKNLSHYAHPVEDAEIILTQVQAVEQNRQLLEEPDLVEPLISSLTQVLRQELNRLKQAWDQEWEKGEARLEKDENWHRLAREQRHELRNQQGLVEASIPSIQLDSTDSILNTLNTAGISALKDRIAAMPGRYSQMLMEAARMLEPEVQEVALPSSILKTEQDVDEWLTQARKKLLEQLKSGPVIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK41</accession>
    <name>D6SK41_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3701"/>
    <dbReference type="EnsemblBacteria" id="EFI36244">
        <property type="protein sequence ID" value="EFI36244"/>
        <property type="gene ID" value="Dthio_PD3701"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="701" mass="78227" checksum="E72D11A8671B34F0" modified="2010-08-10" version="1">MNRHKSSQGGFVMMTVISLLATIMVLLSAYFFTTNIETRSVQSSLGSVTGFYSAEAGLNIRGEEIRQLFIGFQRPSGTSPDENNPCQNNNQGSGDFECKTYSYNDRDIITYVVEDEDNQNDNVIRIPQGELFAGLNAVEYRYTVLSEAAPKKDDRPEAILEMVFRSRLVPLFQFAAFYDKDLELLPGEDMELFGPIHANGDIYTGADGANLNIDGQITASFNPEDQHSEGGGRFHIQRKDNTSTQFEDTVHVNDGTGNFETIPGGGMIEQEVLDDWNGLIETELDALTVPEAHDFEPGGEYWQKADLIVALDMTDVNDPAIVVPERKNKDSIENQMTQTLNMPLCIDSVDCDLEEVEDQDDAPRNDPDLFSVAYDDDFLDEIKGEELMISRYPVEASDSFHDSREGGNITMLEVDLPFLLSRIHESSEKHGDCTGDITIRNLLSDSPHYNFNELNIDTSGDGGLVIYFTVIKDYDPGQDKGEYGVRIRNGAHLGACDDTLEEMGLTPGEAPKIQGLTLVSDIPFYIQGHYNLNDPSDHSASRDPNQAEGSVLPEEGLEYENWRPAAIIGDTINILSQGWDNDSDSTTGGDGPVTNAETRVNAAFLAGTDSTQELNAAYSGGLENFPRFHENWGTTRFYYQGSFVSLNESRHASGDWGDASYNPPARPWTYDERFNYMENLPPLTPRFVYLKQERFIRDFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK81</accession>
    <name>D6SK81_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferritin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869403.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3747"/>
    <dbReference type="EnsemblBacteria" id="EFI36284">
        <property type="protein sequence ID" value="EFI36284"/>
        <property type="gene ID" value="Dthio_PD3747"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2076363at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="2">
        <location>
            <begin position="65"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="189" mass="20885" checksum="55B18EACB8803E15" modified="2010-08-10" version="1">MSQKADRHKNLPHPMRITNQVLSRRSLLRTGAGALGIFLAAPGLTWASPGDTRQSEEAIELMILALQHEHGAFVQYANHAALLSMWLEEDLTRTYETIIADEVSHAISLVTALKKSGAEPTLAVWPARSGDDPGTLLRQDIAAEENAVEIYRRIIDLDISSGLRTELEKILKAEKAHQEVFEELLSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK92</accession>
    <name>D6SK92_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LapA_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869414.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3758"/>
    <dbReference type="EnsemblBacteria" id="EFI36295">
        <property type="protein sequence ID" value="EFI36295"/>
        <property type="gene ID" value="Dthio_PD3758"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2039833at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010445">
        <property type="entry name" value="LapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06305">
        <property type="entry name" value="LapA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="LapA_dom" evidence="8">
        <location>
            <begin position="38"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13663" checksum="146BABA0266D2CD6" modified="2010-08-10" version="1">MRYLRVALLILLFFFAMLFFVQNHELLSKTVKLHLEIFGAEFTSTDIPYYLIVLLGFLAGGFIALIYLLGEKIRMNGEVKRCKAKIADLEKEITSLRNMPLEDDSLGLNTSSQEEQESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKB9</accession>
    <name>D6SKB9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3788"/>
    <dbReference type="EnsemblBacteria" id="EFI36322">
        <property type="protein sequence ID" value="EFI36322"/>
        <property type="gene ID" value="Dthio_PD3788"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="11528" checksum="347CA124A7EC6051" modified="2010-08-10" version="1">MIRTFKSADTEDIFDGVASQAARRCCPQNIWPVTRRKLDQINRVRDVNELKLPPGNRLERLKGDRENQYSIRINQQYRICFIWEEGDAYEIEITDCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKF9</accession>
    <name>D6SKF9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD3830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3830"/>
    <dbReference type="EnsemblBacteria" id="EFI36362">
        <property type="protein sequence ID" value="EFI36362"/>
        <property type="gene ID" value="Dthio_PD3830"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="146"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="265"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="410"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="663"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI36362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="789" mass="89108" checksum="2EFC6B6EF4928462" modified="2010-08-10" version="1">MCPAKHFPKEKYSSPSTASLDYQDMLMHAPLGCFQSTPEGKFIFVNHAMASIHGYDSAESMLESVTDIASQIYAEPADRGRITRLLEVHGEVVNHECRIIRRDGYEIWVSLNIRAVTGSDGLISCWHGFVSDITRRKQSQEMQKKHHEKLDSFLRDIPAMICCFNPQGVITYINQQYCDYFGMPQEELLGSIFLDLIPGKDKEISQQNFTSLTTEHPVKTVEHRVQLPDGTIRWHRWIDRAVFDEAGTPEYYQSVGLDITEIKTQQLKLESIFEACKDISFVIAESCPEGDLRITDFSPGAESVHGYQKQEVVGQSVAMLHSREDLEKFPEIYTSIRQGRVWRGSMFMQRKNGQVFPALFTVYPLEIEDRLSALGVAVDISELEEVRRALQKAKEAAEAASQAKSTFLANMSHGIRTPMNIIMGFARIMERDFSLSRQHLRQVQTISRNADNLLRILNDILDMSSIEAGQVRQHAEDFDLHHFFEQLMGMLLSRADSRGLELSFERAGYIPRYVHGDQGMLRQILINLLDNALKFTSRGWVKCSIKNIQARSAADDSPDVFKLEFRVEDTGPGISSDEQENLFEPFYQTVAGTQEGGTGLGLAISLRYSRIMGGDLWYENRQGGGSCFCLHVPLLPACRPCRDVQEVPLRMVSGLAQGSSPVRVLVVDDKQDNRSMLLALLKPLGFQVREAAEGAEALQVFEHWLPHAVLMDMRMPVMDGYETTRRIRLMQGGEKVCIVAVTASVAHEHINDILAQGVDYYLGKPFKPDELLDILKEALGLSYTYSDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKK1</accession>
    <name>D6SKK1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868346.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2621"/>
    <dbReference type="EnsemblBacteria" id="EFI35212">
        <property type="protein sequence ID" value="EFI35212"/>
        <property type="gene ID" value="Dthio_PD2621"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="156"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="32475" checksum="F2EF0656C847649C" modified="2010-08-10" version="1">MNKHKSLLKTGYSRGIILAFTGAFVLSFDSLLIRLAMADPWTVLFWRGLLMGLTLSLVFYCDCRKLPFWEIKTQGSAALASGILFGVTSTGFVISILNTHVANSVLIFSTAPMFAAIFTRFILKEDIQARTWLAILAVMAGVAIVFKGSLGTGNLMGDLSALVAAVAVGGNYTILRRRPKIKRTAVVSLGGFATAALAFFWASPLSLELSSFMVLALMGIVQMPLASVLLAVSTRNLPSPEVSLFLLLEAVLGPFWVWLVIRESPPGLTWLGGLIILGTLTLYFAPALRRDPEVKPAHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKL4</accession>
    <name>D6SKL4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868359.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2634"/>
    <dbReference type="EnsemblBacteria" id="EFI35225">
        <property type="protein sequence ID" value="EFI35225"/>
        <property type="gene ID" value="Dthio_PD2634"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="14880" checksum="00E2D3DDAC324B2A" modified="2010-08-10" version="1">MNLLVPHDGSEFANKTMDKAIDFCRKLGGGKVYSVVVVPDLCISFVGRDECNLLESTLQKEGNEIKNNVQGRLTEKGVDGQVMIKSGAPEKVILETADEVDADYIVMGASGSHGADARGVLGGVTCKVINTGKRSVIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL86</accession>
    <name>D6SL86_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868579.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2867"/>
    <dbReference type="EnsemblBacteria" id="EFI35447">
        <property type="protein sequence ID" value="EFI35447"/>
        <property type="gene ID" value="Dthio_PD2867"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="357" mass="38136" checksum="041D09E153A27ADC" modified="2010-08-10" version="1">MSHFENGHLPPEYRTYIRRKGLFLIFLAVLGVLFFILAISKGAVYIPASDVLRILLGQGEESRFQTIVLNIRLPHALAAFLAGAGLAAAGAAMQSILRNPLGSPFTLGISQAGAFGAALAVMILGAGVMQSTQVGAVSILNPYLTTIVAFIFCMLTSMVIVAISRLRGATPEVLVLSGVALGALFNAGTMFLQYFADDIQLAAMVFWTFGDVGRAGWNEIRIMAVVVAVCLVFFVYNRWNYNAIEAGDETARGLGVRVDRVRLLGMLMASLATATIVSFLGIIGFVGLICPHIVRRVIGDDHRFLMPASCLTGGVLLLASDLAARLILAPHVLPVSVLTAFLGAPAFLYLLIKGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLA3</accession>
    <name>D6SLA3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35464">
        <property type="protein sequence ID" value="EFI35464"/>
        <property type="gene ID" value="Dthio_PD2884"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZUJ8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="56" mass="5904" checksum="49FF1B604B496D95" modified="2010-08-10" version="1">MNIPIFRGVILGGTVGLTASLIFGIDPLRALILGVLCGLLGVATRVAIENRKEKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLI4</accession>
    <name>D6SLI4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2969"/>
    <dbReference type="EnsemblBacteria" id="EFI35545">
        <property type="protein sequence ID" value="EFI35545"/>
        <property type="gene ID" value="Dthio_PD2969"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="359"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="418" mass="48256" checksum="6AF4A034AEAB5B5C" modified="2010-08-10" version="1">MMRYFKIISIYLLVFFICGCAVQDRVQQQRAQYTEPPFQIETFDTQIIHHEEVSGDIRLVVAAIVEQMRNEDNTSQYVSFNNRGSHRLTYPAFHFNGFSLTSTLIQNYNCETVNNVNECYLDGFFTFADDFQRTSIDYFNVEYAVHDNSIVIHDSFAVNAPPTIPRLQAYIVPREDFSKVVDRADSYYSFYAGIVSSAHNIVPTDEEQRQHEKLEQMSFFERLRSGVTREREDNVVIIFAMDRLTPNAEFEVQVTESLYSSNSLVTPEYINYQGWRAAIFGGNFAIDRDNFYIKAYYEPAIDIYPDGTERILAGLFTPEKDYEGQKKVQRERMSQQREHTPREGPLSRGESVLDTSDRSDARIIQTRLAELGYYNMIIDGLWGPGSRGALEQFQRSSGLEASGWNLQTQRSLFEGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLK3</accession>
    <name>D6SLK3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868696.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2990"/>
    <dbReference type="EnsemblBacteria" id="EFI35564">
        <property type="protein sequence ID" value="EFI35564"/>
        <property type="gene ID" value="Dthio_PD2990"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZGFC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="7705" checksum="99C70409BF9727C4" modified="2010-08-10" version="1">MHVFADGISKVTLSNGNLRIMLTQRGADDSTVEAGTMIIPASQASNFLNGLANSLKELESRLKEAREQTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLL5</accession>
    <name>D6SLL5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3002"/>
    <dbReference type="EnsemblBacteria" id="EFI35576">
        <property type="protein sequence ID" value="EFI35576"/>
        <property type="gene ID" value="Dthio_PD3002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="115" mass="12833" checksum="623E1FB51926B658" modified="2010-08-10" version="1">MGTIAEMFSDLLEKPCHKNKNHAKKRGRPLNRKDAKYAKFKTRSRCIVQNRDTVLDKAAFSFAACPVKSEACLTGVHPANEKNLPAFLCDLCVFSESSNGRLRFLCFLGCGQSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLP8</accession>
    <name>D6SLP8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868738.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3038"/>
    <dbReference type="EnsemblBacteria" id="EFI35609">
        <property type="protein sequence ID" value="EFI35609"/>
        <property type="gene ID" value="Dthio_PD3038"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="343"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="486" mass="55368" checksum="05E5FF961460504F" modified="2010-08-10" version="1">MNGSHAVFHLVDISRDLKREIEDNLPGDTAVNEVDGSDSLSTDGGSQSRIDILFLSPGRWEKMDQEMREWLESRNQHLVLVLEDEQQKPDQEYNVSASFLGYLRRPVTRNALKSIRDKAREVQELYTDLHLMAKEIVLERELLTRKNAQLEFLNRILTSTSQTLDLKEILHQTSKEFGTLLGTTGLAAIFWNYDNEDLFAEIYLPEIKSLKTRQKWTGHLMEIVQRFEGSMPRHYHTVVMGEGENTLSKPPSHARQIMLPLQAGQKTFGAIILDAKEILNLGKDQVTIINSAARHLSLSLRNALEYKAVKYEAEFDGLTCINNRQHFDKKLRKELKRHQRQVNSLSLIMLDLDHFKTLNDTYGHVTGDMVLRKIGEILVDTVRETDFPARYGGEEFVILLPETTEEQAWLLGQRIRQKIGQTEFEVQGKKFSITASLGVASIKPGPLTPKDTLVEQADQALYLSKFNGRNMVCTSADVCMDQAVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLY4</accession>
    <name>D6SLY4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SagB-type dehydrogenase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868824.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3124"/>
    <dbReference type="EnsemblBacteria" id="EFI35695">
        <property type="protein sequence ID" value="EFI35695"/>
        <property type="gene ID" value="Dthio_PD3124"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="28885" checksum="A9769EB60953A668" modified="2010-08-10" version="1">MSDKKPGRDFLKDSLRKETDFSQTDQNRGVPAPPLQKPYDPSLYRLSLSSEKEWKSYIKDLSLDRIIANRKSRRKYSDEPLQIQELSFLLWATQGIRKQNSDFTALRNVPSAGARHSFETYIFARNVQGLDPALYRFLPLENELVLLKSIPGMTADLSRAAFGQKFVGLGAATFVWSCIPYRMEWRYGPTAYRVILMDAGHVCQNLYLACEAIGAATCAVAAYDQEAMDELVGLNGQDEFAVYVAPVGKALTIPDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM22</accession>
    <name>D6SM22_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin-dependent glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3162"/>
    <dbReference type="EnsemblBacteria" id="EFI35733">
        <property type="protein sequence ID" value="EFI35733"/>
        <property type="gene ID" value="Dthio_PD3162"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="151647at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="2">
        <location>
            <begin position="295"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="546" mass="59315" checksum="A0AE301E5C90D2EA" modified="2010-08-10" version="1">MKASKSNDVLGTVNRGSPAESGLCTLCRADCAGKCETWLASLKGREVLYPRDYGKVTAGADNTTHVGVSYNSLRIQGYNYGSSGLPQGVSNDPDNCTFPGADVSTSFGRTKKIQARMPIMTGALGSTKIAETYWDSFAVGCSLVGVPIVIGENVVGVDRNSRMKNGRIVDAPELDRRIQTYMRYFDGHGAVLVQLNVEDGRNRVADYVAEKYGGDKVLIELKWGQGAKDIGGEIEVFSLEQALFLKKRGYVVDPDPELSEVQEAFKRGSIKAFARHSRLGFTDFEKYEDIRSNFKATVEYLRGLGIRGITLKTGAYGMEALAMAIKLAGENNIDLLTIDGAGGGTGMSPWHMMQSWGVPSILLHSKAYEYARILDEKGENVPDMSFAGGFAQEDHIFKAIALGAPYSKLVCMGRALMISGFLGSNIQGVLQPEKKEKIGGNWDKLPKTVSDFGSSPEEVFAGYYDVQKKVGKDEMADIPFGAIAFWTMADKLKAGLQQFMAGSRKFALSEIDRGDLAAGNRETAMETGLPFITEAQDNTAKEILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMB0</accession>
    <name>D6SMB0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD3257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868950.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3257"/>
    <dbReference type="EnsemblBacteria" id="EFI35821">
        <property type="protein sequence ID" value="EFI35821"/>
        <property type="gene ID" value="Dthio_PD3257"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="343"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="435"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="679"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="809" mass="90659" checksum="AFBB8AA55B7A6DCC" modified="2010-08-10" version="1">MNIFKLTLRKKFLLALVAACLVALVPTILIGWQVLESGKNYFGRAYTENFTLLKAQEIKEPVSKELALAQRFADSVLLRQWLQDPLSENKRSIFFQEAQGYQDVFQDSSYFLVNRETLAYYYNGPDKEKSQEPRYYLDPENPDDSWFFSAMEFGTYNINVNPDVHLDEVKVWINVPVWNGEQKIGMAGTGLDLSGFLQEFIAVDEPGVTPVILDSAGLIQAHPDHSLIAYGSGAEIDAQLRPERHQSFLQSHFSTPGYVQRLNQAMQMARENPAQVQTFWADLDGRKQLISLAWIPELSWHVVTAVDLQSAQVVEGAWLSKAVAVLAVMLVLLLFMFAYGVERIVLRPLNKLHNSADALARGEYDVDLPPAGSDEVGGLTRAFSGMARKIKSHTRELEDRVRERTGELEEKSSQLEAARDKAETANRAKSEFLANMSHEIRTPLNGITGMMQLLQTTRLDSNQKEYVDLALSSASRLTRLLSDILDLSRVEAGRMVILEEEFNVQELCRSVCELFRIQAGEKGIELEYTLDPSLPSRLMGDETRLQQILFNLVGNSLKFTREGRVRINWTLQKRGLDRHQVLITVTDTGSGIAPEKLDDLFQPFVQEDGSSTRRHEGAGLGLSIVSRLVDLMHGTISVDSAPGEGTAFYIFLPLKVPAAPEADQDDALQNHKGAGKPLRILVAEDEPTNQLFAGRLLEYLGHKVMIAEDGSQALELLQQHEFDCILMDIRMPFMDGLEAARAIRTSRELGARRDVPIIAMTAHAMEGDREVFFQAGMNGYLAKPVQKEDLEKVLQGIQNKVGGYLYTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMI9</accession>
    <name>D6SMI9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proline--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="9">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">proS</name>
        <name evidence="11" type="ORF">Dthio_PD3339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869028.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3339"/>
    <dbReference type="EnsemblBacteria" id="EFI35900">
        <property type="protein sequence ID" value="EFI35900"/>
        <property type="gene ID" value="Dthio_PD3339"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001535">
        <property type="entry name" value="ProRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="38"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="577" mass="65026" checksum="24B5606B58595F02" modified="2010-08-10" version="1">MRWSRYFMPTLKEEPAEAEVVSHKLMLRAGMIRKLTAGIYTYLPAGWRALQKISEVIRGEMNRFYAIELLMPAVQPGDLWKETGRWEAYGKELLRFRDRHDRDYCIGPTHEEVITDLIRREVSSYRQLPLNLYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFDKDEAGAAQSYEWMRQAYVSIFEKLGLQFRGVEADSGAIGGSVSQEFMVLADTGEDVIATCTHCDFAANLEKAEVTCASEDCPECSLPPEKVMTPGMHTVPQVAEYLNVPERKVLKTLLYDADGMAVAALVRGDRELNEVKLGNLLGAKHLQLAGQEQVEKWTGAGMGFAGPVGLKVDKIVADLELRLETDWITGANADDAHLRHVDLRRDAQVNAYHDLRSITREDPCPRCQGGIRMTKGIEVGHIFMLGAKYSQSMNAAYLDEHGAEKPLIMGCYGIGVGRVLAACIEQNHDENGIIFTPAIAPFEVTIIALNPKDEMVRNHSESLYNELCSQNVDVLLDDRDERPGFKFKDCDLVGSPLQVIVGAKGIKNGVLEVKERHSGHRHELPLEDFGRHFQEVRRKVREHFGLDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMM9</accession>
    <name>D6SMM9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3382"/>
    <dbReference type="EnsemblBacteria" id="EFI35940">
        <property type="protein sequence ID" value="EFI35940"/>
        <property type="gene ID" value="Dthio_PD3382"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="3">
        <location>
            <begin position="86"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="323" mass="34782" checksum="341AB4602D1E223D" modified="2010-08-10" version="1">MNKKYRVLKRLMPENSLSRRDFLKSQAGLAAAVAFSGLGVLGQASVSSAGNSPDIGVARGGPAEAARACVDLMGGMSSFVSSGDKVVIKPNMSFAHTPDRATNTHPRVVRTLAEMCVEAGASRVMVLDNTLQSAQRCMELSGIRDACADIPNTRVETLDARRFFQEVSISEGESFRSTEVMRDVLDADVLIAAPVAKSHSATGVSVSMKGMMGLIRNRGVMHSRYNLNQAIVDLCTLLKADLTVVDATRVLSSHGPQGPGDVIEGELVLASRDMVAADAKTVELFPWYGRKIRPDQVEHIKMAHERGLGRMDLDNLEIQTVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMU9</accession>
    <name>D6SMU9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD3452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869138.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3452"/>
    <dbReference type="EnsemblBacteria" id="EFI36010">
        <property type="protein sequence ID" value="EFI36010"/>
        <property type="gene ID" value="Dthio_PD3452"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="339" mass="38647" checksum="49D0305F729AC4FC" modified="2010-08-10" version="1">MNILVTGGCGFIGTNFIYFMLNESQHTLINLDKLTYAGNLENLRSVEERYAGTRYFFEHGDICDAELVPDLLKKYSIDVIVNFAAESHVDRSINEPGMFIQSNTQGTYNLLEASRQAGIKKFIQVSTDEVYGSLGPQGSFKEDSPLAPNSPYAASKASADLLCRAFFKTYHFPVTITRCSNNYGPFQFPEKLVPLTFLRARDNESIPVYGQGENIRDWIYVSDHCRGIKLCIEKAGPGSIYNFGGNAEYKNLDVIKKILDIMGKSHKLIRFVQDRPGHDLRYAMDFTLAKKDLGFEPSVKFTEGLELTINWYLNNNKWVDSIKSGDYIRFMDKWYKERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMY4</accession>
    <name>D6SMY4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3488"/>
    <dbReference type="EnsemblBacteria" id="EFI36045">
        <property type="protein sequence ID" value="EFI36045"/>
        <property type="gene ID" value="Dthio_PD3488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="45" mass="5219" checksum="EE46E6B0B2421C5B" modified="2010-08-10" version="1">MLTYGELLEILQSFDEKQLRQPAMIHIKDSEYMQQAQQVVVPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNF5</accession>
    <name>D6SNF5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869609.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1632"/>
    <dbReference type="EnsemblBacteria" id="EFI34281">
        <property type="protein sequence ID" value="EFI34281"/>
        <property type="gene ID" value="Dthio_PD1632"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="242"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="468" mass="52794" checksum="164B583E3AE78873" modified="2010-08-10" version="1">MPDNEKSTRDRLQELREKAEKSLKEYDDLSGPASEFEDVQEVLQELSVYQVELSIQNEELQAKQEQLERTSNEYRRLFDFAPVGFFVFDENGIIEDVNRYGAEMLGMDQRTLHGKPFMLYLDTTYQRAFSDHRRRVFSKKPVAEDVSLKLKVQNSRGIWARIKSIAVEHGDQKALRCFTAMQDITRQVEYSEKLLEMNRTLEGTNNMLRQEIEARKKVEQELIESRDAAEAATKAKSGFLANMSHEIRTPLNGIFGMLQLMEDTSLDEEQQELLQTAKASGRGILTILSDILEFAGLDQVEPRLENRPFDLRSVVQQTIQSLEASARQKGLGIKLSIAADLPGEVCGDQARVRQILFNMLSNAVKFTQDGEIHLDVSLLRSYEDSILAGFALSDSGPGISDDLIFQVFQPFSQADNSFTRRHGGLGLGLSIARNLVKLMGGTIALDTEEGRGSTFYFTLKLGLNCPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNH3</accession>
    <name>D6SNH3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yidC</name>
        <name evidence="16" type="ORF">Dthio_PD1650</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1650"/>
    <dbReference type="EnsemblBacteria" id="EFI34299">
        <property type="protein sequence ID" value="EFI34299"/>
        <property type="gene ID" value="Dthio_PD1650"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028053">
        <property type="entry name" value="Membr_insert_YidC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01900">
        <property type="entry name" value="YIDCPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03593">
        <property type="entry name" value="yidC_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="YidC_periplas" evidence="15">
        <location>
            <begin position="81"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="547"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="598" mass="68104" checksum="A148A5030198CA5C" modified="2010-08-10" version="1">MEIHRVLIAVVLSLAVLVVWNLLFPPQTPDREEVREEERLEETVPEERDLAPEPDPREEAEDTWDPHEAQIPGFEPEEGEQIKVDTPLYQATFNSAGGILEHFVLKEYKQDIEPDAPMVDLVTPRSLARGPMGITWNRAPTWIEGEWALNGEDLDLEPGDEKTLTFTGRMGGVKFIREMTFVADTYKIQENLQVVNTTEAQASGEIANILAGPAFSDSRLNPTRLGYYDQDGLSHEREGNLSDGISRNTGIQWAGIVDHYFMLTLVPASPDVQLQAHHGDDLFQISLSKSMYLEPETSQTMDQIYYLGPKDREYLEGAPNHLEESIYYGWFNLLAQPLMKVLHFFYQYTANYGVAILLLTLVIKIIFWPLSHKSYKSMNQMKKLQPMMTKIREKHKDDRKAMNEEIMRLYKTYKVNPLGGCLPILVQIPVFIALYQGLLGSVELRHAPFISHIPFTDIVWLADLSARDPFYITPLLMGATMFLQQRMAPAPGDPLQARIMQFLPLVFIFIFITFPSGLVIYWLANNVLSIGQQWYMLRSADVPLQKAEQKAAEKAGKSSRDKEDQGDSQEESQEKPGEQQQKSPQQKSAASKKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNH8</accession>
    <name>D6SNH8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DegT/DnrJ/EryC1/StrS aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1655"/>
    <dbReference type="EnsemblBacteria" id="EFI34304">
        <property type="protein sequence ID" value="EFI34304"/>
        <property type="gene ID" value="Dthio_PD1655"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="412" mass="45226" checksum="0F535299948D41C8" modified="2010-08-10" version="1">MEDRLSIPFIDLKSQYSRIDSRVKEGLDRVLAHGAYVMGPEIAELEKELAAFCGAQHALACSSGTDALLLALMAKNTGPGDAVLTTPFTFCATAEVIALLGATPVFVDIDPETFNIDPDSLKLAIQALRSADPDVYPLPSQAKAAGEPGKGPHAPSSMPHAHLIPKGLISVDLFGLPCDYEAINPILEEEGLWLLVDAAQSFGSSYKDVSPCTLGDTACTSFFPAKPLGCYGDGGMCFTNDTSLHQVLESLRVHGQGKNRYDNVRLGLNARMDTMQAAVLLAKMSIFPEEIELRNIVARTYNDFLQEAQDITVPSFFPDRQSAWAQYSVLARDQEHRQTVFDSLKENNVPWSVYYPLPLHLQDVFSYLGYSSGDFPVSEEMSKRIFSLPMHPYLKQSDQEKVARAVVEGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNP1</accession>
    <name>D6SNP1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HdrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869695.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1718"/>
    <dbReference type="EnsemblBacteria" id="EFI34367">
        <property type="protein sequence ID" value="EFI34367"/>
        <property type="gene ID" value="Dthio_PD1718"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="670" mass="72960" checksum="FD59465480133DA6" modified="2010-08-10" version="1">MAKVGVYVCYCGTNIAGVIDIETVRAFAETLPEVSVARKDLFMCSDSGQELIKQDIREGLVDRVVVAACTPRTHEPIFRAAVQSAGLNKYLFEMANIRDQDSWVHPDNPEEATNKAMRLLASAVGKASRLKPLEEKYVDVTPAAMVIGGGVSGISSALELANMGYTTYLVEKDPSIGGIMAQLDKTFPTNDCSACILTPLMVDVANHPNIKLMTYSEVEDVEGFIGNFTVKVRRKQSYVDWKKCTGCGDCATSCPVRVPNEFNHGMDQRPSIYIHFPQAVPKKAVLDVESCINCAGHKLGREPKISKKTGNPMIAPCQKVCPADAIDRSQQLDPQGSIEEVKVGSIVVATGFQVMDKKWFKEMAPDSPNVITALQLERLISATGPTGGKLYMPSTANKVPETITFVSCMGSRDEKFHTYCSRVCCMYMVKQARLLKEKYPDLNIYMHFIDVRAAGKEYDEYYTGARKMGINILKGKVGGLEVLPEDRLRVLAYDMEGCVPVEYQSDLVVLATAIEIPETAKKLAHATGLQFCGSHFYRELHPKLGPVETSVEGLFLAGCCQGPKDIPDSVSQAKGAAATAAVPLAQGKVKIEPIISEVHTEKCSGCGICVPLCPYDAITMKMVDDHPRAEIDMTACKGCGVCTTACPSAAIVLHGYEEEQIYAQIEALTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNW9</accession>
    <name>D6SNW9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate synthase (NADPH), homotetrameric</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869767.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1804"/>
    <dbReference type="EnsemblBacteria" id="EFI34445">
        <property type="protein sequence ID" value="EFI34445"/>
        <property type="gene ID" value="Dthio_PD1804"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="2">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="154"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="474" mass="51429" checksum="8CB0AD1DD8409875" modified="2010-08-10" version="1">MQKKAKTKTKISPRVSMPMLDAVERGRMFSEVALGYTLEQAVSEAKRCLQCKKPTCIKGCPVDVDCKGFIRMVADKDLAGAFARIKETNSLPAICGRVCPQENQCEKTCKLRPTGQPIAIGRLERFVADNYYAHTSCEEETGADSCVPIDESLKVAAIGSGPSSLTLAGYLAANGVKVSVYEALHSPGGVLLYGIPEFRLPKSVVQREIDSLKNLQVDFLCNYVGGKSMTLPELFQQGYKAVFLGVGAGLPRFMNLPGESLIGVYSANEYLTRVNLMFGYRFPEYDTPVPPGRNVVVIGGGNVAMDSARTALRLGAERVRVVYRRTKGEMPARQEELEHALEEGIELEILSSPLSFHGDDQGVLNKMVLQRMELGSPDDSGRRQPVPIEGDTFSLDTDLAIMAVGTGANMVLTQTTPELELNERGYVRADPETGETSMNMVFAGGDIVTGAATVVEAMGAGRRSAREILKRIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNX6</accession>
    <name>D6SNX6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869774.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1811"/>
    <dbReference type="EnsemblBacteria" id="EFI34452">
        <property type="protein sequence ID" value="EFI34452"/>
        <property type="gene ID" value="Dthio_PD1811"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="PTHR14614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="217" mass="24527" checksum="6A886BE60609F113" modified="2010-08-10" version="1">MQDLSQVLNLKLAGHRLKLKRQADLETLWSGLEEPSRDMDQERIPYWAEVWPSSVLLAEHLDRNRELIRGRLCLEAGCGLGATSILASRLGARVVAVDMEPDALVFARQSAKANNTPEVLWAGIDWKRGGLKKNLFEFIWAADVLYETGFALPLAGFFRNCLAPGGRIWIADQNRNVSADTWARLLSQGFKAKEIEERRVSWFGQKAGVRLLELVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP26</accession>
    <name>D6SP26_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869824.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1861"/>
    <dbReference type="EnsemblBacteria" id="EFI34502">
        <property type="protein sequence ID" value="EFI34502"/>
        <property type="gene ID" value="Dthio_PD1861"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1359310at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="26787" checksum="3313BCCC3E97FEFA" modified="2010-08-10" version="1">MQDVNQEKIVGIIGGMGPEATVDLMSRVIRLTPALDDADHIRCIVDNNPKVPSRIKALIDGAGESPVPELQDMARCLEAWGADFLAMPCNTSHYYFQDIQGAVSIPMLNLIEITVQEVLRQQPGIDKVGILGSTALILTGLYQQAFAASGVRVVYPETACQDRVMVLIKDIKKGAMDLAFPVFESSVSSLETQGAQALVIACTELSLLPDASLSSAHQPLPRYDSSDILARDIIRTCKVKNLKSIGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP63</accession>
    <name>D6SP63_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1911"/>
    <dbReference type="EnsemblBacteria" id="EFI34539">
        <property type="protein sequence ID" value="EFI34539"/>
        <property type="gene ID" value="Dthio_PD1911"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="288"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="682" mass="78533" checksum="FA839405701DED6C" modified="2010-08-10" version="1">MNDYKHHRAELRPGQVVEYLQNNQPLVSWIQEVQSPRVRVLNINQREVKLPIARVMPWTGPVYSPDLSRQDVLQLLQEHHHRRNSIQEDLDVMDVWSMAQGEIVQASIFWFAGLIWDEPDADRTAALGRAMLQARTHFKFSPPDFEVFSRETAEKKMEEERLHRERERLVSIGKDFFRKLHSGEYSPGDQPEPEDPELAGQLKNILVQRIKNPEDPHTQDLWSKLSAGLPQDPHLPFILARAWGIYPEHYNYMLEQAAYAWEDSWSKTHDPEIQALSRKLEQESGEPAVDGLISIDSASTRDIDDAFYIREHADGYSLTLALAGPGLYWTFGSELDRDVAHRVSSLYLPEGKSDMLPRILAEEMFSLNQGQRRPAMVLDIDLDFQGIVYRLQPRLEWVRVQANRTYAEVEDELAMDPASRLGSALRLARTLRAKRLEQGAVIIEQNEPIIRLEHTPRQTLVSLMPGVTHPGAHLIVSEFMLLCNTVLASWAREKDIPLLYRTQDIVLPKDYSGVWRKPEEIYRVIRSMGATLTETRPRPHRSIGAGAYASVTSPLRRYVDLVNQAQIAAALSGHPVRDRTWLEKMLPFMNTRMGQVSRIQKFRPRYWKLLYFKQQARHTTWTGVVVDNSGPVVLSLPREQVLIRAPHEVFGGKTMIGQAFRLRLGRIDPLNNEIHVLEAWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP83</accession>
    <name>D6SP83_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869879.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1931"/>
    <dbReference type="EnsemblBacteria" id="EFI34559">
        <property type="protein sequence ID" value="EFI34559"/>
        <property type="gene ID" value="Dthio_PD1931"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="254" mass="28745" checksum="5A9DB2A917D92A17" modified="2010-08-10" version="1">MQWNIVVANQKGGVGKTTTAVNLAASLAVMEKKVLLVDCDAQANASSGLGLDIDSLEYSLYHGLTGEAEPEKLIRPTEMKYLDIIPSNKDLVAVELELNDRQDREYYLYKLLKNVSKPYEYIILDCPPSLGMITINAMCASNRLLVPMQCEYYALEGIARLFETYELIRKRLNNDLELLGVALTMFDKRNKLCHQVIKEIRRHFQAQTMDSIIPRNVRLSEAPSHGRPVLAYDIRSTGSHAYLRLAREVVGRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPC9</accession>
    <name>D6SPC9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869925.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1977"/>
    <dbReference type="EnsemblBacteria" id="EFI34605">
        <property type="protein sequence ID" value="EFI34605"/>
        <property type="gene ID" value="Dthio_PD1977"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1250894at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011435">
        <property type="entry name" value="UmpAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07556">
        <property type="entry name" value="DUF1538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="231" mass="24555" checksum="4CD673DC372DBF58" modified="2010-08-10" version="1">MTSEFKEGLIEVVQAVLPITAVVILLQVLLISMPWEEFARFLIGVLFVMSGLLLFLQGVKIGLLPMGEAIGAELPKHGSLIFLLFFAFILGYAVTMAEPDVWVLAGYVDTVSEGMVSRYILVLFVALGVAIFVTLAMLRIVLNIPIAYIFAGGYTLILILSYFTPTDFVPISFDAGGVTTGPVTVPFILALGLGVTAVLGGKSSFNDGFGLIGLASIGPVLSVMILGIIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPE1</accession>
    <name>D6SPE1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1989"/>
    <dbReference type="EnsemblBacteria" id="EFI34617">
        <property type="protein sequence ID" value="EFI34617"/>
        <property type="gene ID" value="Dthio_PD1989"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032U08">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="220" mass="24471" checksum="CC39880C723053BA" modified="2010-08-10" version="1">MPNDNSEAICGLCQKGLTARGIGRHLSSCLKKNLYRIADDKKEGPGILHLKVHEGYSGSIYWLHLAVNRDIKLSTLDSFLRKIWLECCGHMSAFFAGSPFGTEELSMNSRIDRHLDPKHRLSYIYDFGSSTTLAIDCVGEYPGKLRKNDKITILSRNEDPQILCDVCQSETAESICHECGMKDGGAYLCSRCLEKHKCGKEMLLPVMNSPRCGVCGYDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPF2</accession>
    <name>D6SPF2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="16" type="ORF">Dthio_PD2000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869948.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2000"/>
    <dbReference type="EnsemblBacteria" id="EFI34628">
        <property type="protein sequence ID" value="EFI34628"/>
        <property type="gene ID" value="Dthio_PD2000"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1419877at2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="180"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI34628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="331" mass="36370" checksum="3C70A0F914BEE9EF" modified="2010-08-10" version="1">MTRIAVLGGGSWGTTLAGMLSEKGLDVRLWIREKELVDEIRKTGENSLFLPGIKLDSRLNVSQDQFEVMQGADYFLVAIPTQFMRKALEGVKDLFPENPVIICASKGVELATLKPMSAVVQESLQEKKPRYAIISGPSFAGEVSRKLPTAVSLGCRDQELGRRVRDVLSTDFFRVYDNPDYKGVELGGALKNIMAIAAGISDGLEFGHDARAALITRGLVEMARLGVALGGRERTFMGLSGMGDLVLTCTGDLSRNRQVGLKLGRGMTLDEIVEGSRMVAEGVKTTESVWHLARKMRVDMPITEQVYQVLFQGKDPRTGVQDLMTRDLKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPF8</accession>
    <name>D6SPF8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division coordinator CpoB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cpoB</name>
        <name evidence="3" type="ORF">Dthio_PD2006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CpoB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869954.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2006"/>
    <dbReference type="EnsemblBacteria" id="EFI34634">
        <property type="protein sequence ID" value="EFI34634"/>
        <property type="gene ID" value="Dthio_PD2006"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099900at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02066">
        <property type="entry name" value="CpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034706">
        <property type="entry name" value="CpoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014162">
        <property type="entry name" value="CpoB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02795">
        <property type="entry name" value="tol_pal_ybgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009991221" description="Cell division coordinator CpoB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="292" mass="33316" checksum="7FAAA994E2E31B13" modified="2010-08-10" version="1" precursor="true">MLIVKTFLLAVAVFVLSACVTGQSGVDRMQMQIRNLERQQHEDRQEMEQELERHQEELAAATKALEEKVAEAGGPVQASQAHLWAELESLRVQVATMSGNLDALERKVFRMGEDQDIPEEVKALQQRTQKLDRHLQTMASQLGVDLQDEVETAAISDDPDLEPVGDPQTARALYQRALDSFYDREYERAQSLWEEFAENYPEHDLISNAYFWQGESFYQMQEYAEAALAYQEVISNYPDSNKITASMLKQGMSFIELGREEAGQLVLNELLEEYPDSAEARRARAFISEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPH8</accession>
    <name>D6SPH8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869974.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2026"/>
    <dbReference type="EnsemblBacteria" id="EFI34654">
        <property type="protein sequence ID" value="EFI34654"/>
        <property type="gene ID" value="Dthio_PD2026"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="442"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="686"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="806" mass="90179" checksum="41A9A4B4541BD092" modified="2010-08-10" version="1">MNKYADNLCSSEERYRKLFENSPLGIFQADDKGIIVDCNDNFVKIIGSSRQALIGLNIHSLPDTKLVTEFKKSLSGEAGFYEDVYHSVSVDKATPVKVHFAPIFADNGRIQGCMGIVEDVTQKKLDEEEIHKNARRLSEINHCLLGLGQDFETNVQRLTALCGDLLGAACALYNRLESGLLCSMGQWQAPEDYDPRDHPQGHICYDAIKQGQNETMVVTDLDQTEYARTDPNVRRYNLKTYLGHPVKCGEDFVGTLCVVYQENRVPTEDDKKVIGIIASALSAEEDRRQAREDLVRSQESFKRLAEQCPISIMQFDSQGRLIFVNEWHMQHFAGNAVDKQKLLGMHIQELPGLEKAGINEQVSQILNGEHLDVPEIFFPEFIGGGCGWVSLRGVPLKEGDKITGGILIREDLTAWKKTEQELVKARQEAEAASRVKTEFLANMSHEIRTPLNGIAGMLQLLKETSLDMEQKEYVDLGIKSSHRLTRLLSDILDLSRIEAGHMTIHQEEFDPLELCSSVNELFAVTTRNKHLSLECIFQEGFPSRLVGDEARIQQILFNLVGNALKFTEKGGVQVSWSLYAGDDTEQQVRITVQDTGIGMEQEVLQELFKPFVQAENSYTRKYQGAGLGLSIVKRLVELMHGNISVKSVPGQGSTFYVDLPLKAAEDSDVSRQEDSQDSEKALSGLRILLVEDDPANRFAMQKLLQKSGHHVQTAQNGSQAVEAFAHSHFDCIFMDIHMPVMDGVQATRKIRSMQDSGIAPKVPIIALTAYTLNGDREKFLESGMDEYLGKPVQMQDIENVLKKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPI9</accession>
    <name>D6SPI9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase chain 4L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869985.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2037"/>
    <dbReference type="EnsemblBacteria" id="EFI34665">
        <property type="protein sequence ID" value="EFI34665"/>
        <property type="gene ID" value="Dthio_PD2037"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2078994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="107" mass="11590" checksum="6A07A44B11BE739C" modified="2010-08-10" version="1">MHGFYIYAVTAMLLFCLGLWGLASHKNLLRKIVALNVMAGGVFLLFISIANPDQSGQVDPVPQAMVLTGIVVAISLTAFALFLTRRIHEKTGHAELDTSCSIEDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPM8</accession>
    <name>D6SPM8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870024.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2076"/>
    <dbReference type="EnsemblBacteria" id="EFI34704">
        <property type="protein sequence ID" value="EFI34704"/>
        <property type="gene ID" value="Dthio_PD2076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="552" mass="63236" checksum="EFD9149C8AFFF52F" modified="2010-08-10" version="1">MRIGNPFDGRPLGFKNFSDSRLVKKRGESAHPVLEVDKQGHKWFIKNLDSDQEAQIECMIGEIYRYLLGPEQPKIRLADINIVASEGVNFTSVRDLIEKEPNVYDNYQTAFCENIESFLMLAFSSIFFEENDLSDANYGLAKKNGRYGGFVKIDHGQSLNTLRIVEEKRRSSSFNFKKQNLDRAEIKYFPPVNPRPSKDLRKKSQRSSLGPVFYGKRKYELTYQFMDRVVLDFVDGRVDKDYILNLTNQPSASPFYDNRLLGLIDLFGKGKYDIMEVKKHYALARLAFTNDAAYFFIAEKSTEASIQRVQAILNLVKEKIRENRRILIQNLMQDPDFLCFAHVYGSEVKKKIRASWNVMLKKRDGRTTSDRYQKGNAVDPVDSTKLDIASTLGAQYLINLRKHQHLRVRTNENGVVTHENIESYESLVHARSNELIEGLINFIGSHKWNVGFGGGKTVMVKGRKIKVPSHVASLADVLDLHTKTSYRTLRTVKDAADIITDAHHSSSRSRKASTTQAYFALYTQVVEYVRDLRHQGVTDEALRHINPALLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPR8</accession>
    <name>D6SPR8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2117"/>
    <dbReference type="EnsemblBacteria" id="EFI34744">
        <property type="protein sequence ID" value="EFI34744"/>
        <property type="gene ID" value="Dthio_PD2117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="43" mass="4947" checksum="2864A6447BD1E64D" modified="2010-08-10" version="1">MSFSGDKINCADAVRTFWLLMFWEAGGRFVRVLSPELLLNIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPU0</accession>
    <name>D6SPU0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ORF">Dthio_PD2142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870084.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2142"/>
    <dbReference type="EnsemblBacteria" id="EFI34766">
        <property type="protein sequence ID" value="EFI34766"/>
        <property type="gene ID" value="Dthio_PD2142"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="38109" checksum="32B31AC24C937941" modified="2010-08-10" version="1">MERVYILEDGVYLRKNGDNLVLTKNRQTLEEIPVRNLKQMVLAGYAALSGSVLQVLMQNRVETVFLDKNWRFQGRLNVDEHKHVQRRIDQYRNLSDPEFVAESARILVHGKLENMARMLQVRGKRMKNQELLSKAAAIRALGKELGSLQDVELIRGCEGHASRLYFQVFDHLLTNKNFSFKGRSKRPPKDPVNALLSFVYTLLTNEVQTAVKTVGLDPYLGALHVIDYGRPSLACDLVEEWRAFLGDRLVLGLINKKSISVDDFVYRDVKDTDFVDEKDLRSKRPVEMKPAICRAFLQSYEKWMQQKILDPVSGAYSTQSGQSVHGMMDSVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPW9</accession>
    <name>D6SPW9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module component, TIGR02574 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870111.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34795">
        <property type="protein sequence ID" value="EFI34795"/>
        <property type="gene ID" value="Dthio_PD2173"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2087795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013406">
        <property type="entry name" value="CHP02574_addiction_mod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09720">
        <property type="entry name" value="Unstab_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02574">
        <property type="entry name" value="stabl_TIGR02574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8492" checksum="F0809485A709A828" modified="2010-08-10" version="1">MVTKEIKEKILALNEVERVRLAEFIFDSLDKPDPEVEQKLIEESERRYQAYKEGRIHPVSMNEIRQRYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ84</accession>
    <name>D6SQ84_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">Dthio_PD2301</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870224.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2301"/>
    <dbReference type="EnsemblBacteria" id="EFI34910">
        <property type="protein sequence ID" value="EFI34910"/>
        <property type="gene ID" value="Dthio_PD2301"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="118"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="237"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI34910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="389" mass="43209" checksum="6CC73A689A07722E" modified="2010-08-10" version="1">MFLSNKNYVFTSESATEGHPDKVADQISDAVLDAILAQDKHSKVACETLVTTGLAFIAGEITTSGYADLPGIVRQTLREIGYNSSEMGFDWETCSVLSSIDKQSPDIAMGVDRKSQEDQGAGDQGMMFGYAVRENPLLIPAPIYYAHRLSRRLAYVRKRRILDFLRPDGKTEVSVEYINGKPERIDYVVIACQHNEDVSYEDLVEAVREEVIFHTLPPEMLDKNTRIFVNTTSRFVLGGPMADCGLTGRKIIQDTYGGMGNHGGGAFSGKDPSKVDRSAGYMARYIAKNIVAAELAQRCEVQIAYAIGVAEPVSIMVTSWGTGQVPDHVLTQAVREVFDLRPYHIIRRLNLLRPVYSQTSCYGHFGRDHPDFTWEFTDAADDLKTACRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQG9</accession>
    <name>D6SQG9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870309.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2387"/>
    <dbReference type="EnsemblBacteria" id="EFI34995">
        <property type="protein sequence ID" value="EFI34995"/>
        <property type="gene ID" value="Dthio_PD2387"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="267" mass="29405" checksum="1AFF8EBB0B018A5E" modified="2010-08-10" version="1">MNLSPHLKRVATAILLILVLGGAVYMGHAGIAILVVLVSLLGLWEFYSLFWSGRERIVLKTLGCLAGGLFLLDYSLEITGHPLLFLVLIFWVAWLGFLVEYSRQKDQARLNDYMLLISGIAYVPLVLSLFFTLKAPEIILVLAATAASDAGAFYSGYLWGNKKIWPEVSPKKTWMGSLGGLILCTAVTLGLGVFLGSALWWHFIILGILLNISAQLGDFFQSSLKRWCDVKDTGHILPGHGGVLDRIDSLLLLLPVYVVYSVFVGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQI3</accession>
    <name>D6SQI3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2401"/>
    <dbReference type="EnsemblBacteria" id="EFI35009">
        <property type="protein sequence ID" value="EFI35009"/>
        <property type="gene ID" value="Dthio_PD2401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="43" mass="5159" checksum="0DA1F5D579A4E1A3" modified="2010-08-10" version="1">MQYKKFELSIVPGEPFKANLPDFEYMLFDCIQEDLNVYDLEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQI9</accession>
    <name>D6SQI9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870329.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2408"/>
    <dbReference type="EnsemblBacteria" id="EFI35015">
        <property type="protein sequence ID" value="EFI35015"/>
        <property type="gene ID" value="Dthio_PD2408"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030SM5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028462at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="71" mass="8639" checksum="BF1DB1FBF737B715" modified="2010-08-10" version="1">MKTWHWATLIILTLISVIIQLFVPYDQPSWWDRIPVFYVIYGFVGCTLIIFFSKWLGKLMIQKDEKFYDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQJ2</accession>
    <name>D6SQJ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase chain 4L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870332.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2411"/>
    <dbReference type="EnsemblBacteria" id="EFI35018">
        <property type="protein sequence ID" value="EFI35018"/>
        <property type="gene ID" value="Dthio_PD2411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2078994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="125" mass="14022" checksum="2B7A287A4E3BEF6A" modified="2010-08-10" version="1">MLEIIEGYYAYFFLMLLFVIGLYAMMMKKNFIKKILGMTMIQSSAILVWILAAYKEGATVPVLDPAISLDNPDLYLNPLPHTLMLTAIVVAVVTKGVAIGLAVAIYRNYNTLDEDELLARTEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQK8</accession>
    <name>D6SQK8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="16" type="ORF">Dthio_PD2428</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870348.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2428"/>
    <dbReference type="EnsemblBacteria" id="EFI35034">
        <property type="protein sequence ID" value="EFI35034"/>
        <property type="gene ID" value="Dthio_PD2428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="257"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="565" mass="63519" checksum="560B7FE71D15A583" modified="2010-08-10" version="1">MSFIDPREVAEIKSRLSLEDIVGRYVQLKTVGGRLMGPCPFHQETRASFSVTPDQGFYYCFGCQASGDIIEFFKNINGLDFNEAVTQLAAEAGVKLARQGGSPGPASMGRASVCREVNSWSNSFFGQHLQGSNGQKARLYLEKRQISQETAKAFGLGWSPDGWNNLKSFLESRGFTPEDGVEAGVLSRNERGRIYDRFRARLIFPIIALSGAVVAFGGRVMGDDEPKYLNSSESPIYTKGEHLYGLYQARTHITRSSRVLLTEGYLDVMALHQYGFENSCGILGTALTKAQVKRMAGLAREVVLIFDGDAPGQSAALKSAEMILQAGLTCRVLILPEGEDAHSLLVARGRQGLEDLLQKTTDGLDFCLKMLSTNKSPGETMKWVENFITHFKDLSWRSYYIPRVAHVLGLTEKELREKFTPAAQKTPGDTRVWSQQGKGAEQRDRELLTFAVCFPEDRTRLQNKNLGLVLTSQWARQFWDKLRVMHQDDLSALNEDESAFFVQSKMQRAQLEKEKTRILAQIEEFIDRCMTRMSTRNLKTALSRAQQSQDQDEVRRILQLLQKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQQ8</accession>
    <name>D6SQQ8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ORF">Dthio_PD2478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870398.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2478"/>
    <dbReference type="EnsemblBacteria" id="EFI35084">
        <property type="protein sequence ID" value="EFI35084"/>
        <property type="gene ID" value="Dthio_PD2478"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="157" mass="18004" checksum="064337E814959D9D" modified="2010-08-10" version="1">MTRHKPRTKTTHSRHAQREFAFQVLYSLHFDQTGTHILDTFHHFKNDQDTAVQQDMSYALQLINGVRENLEELDAAIGRHSQNWKVKRIAMVELTIMRLAVYEMIYREDIPVKVGINEAIELAKTFGDNNSRNFVNGILDAVARDMRHGEPGTDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQT1</accession>
    <name>D6SQT1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Response regulator receiver modulated metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870421.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2501"/>
    <dbReference type="EnsemblBacteria" id="EFI35107">
        <property type="protein sequence ID" value="EFI35107"/>
        <property type="gene ID" value="Dthio_PD2501"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="6">
        <location>
            <begin position="298"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="5">
        <location>
            <begin position="320"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="502" mass="56942" checksum="F5BB493FD2FC5F09" modified="2010-08-10" version="1">MQKYDQGKKATVLVVDDEESLREICQDALKDEGYEVLQAEDGVQAKEQIARHQDIDLIISDLRMPRLGGLELLQYTAEHNLDIDFLVMTGFASIETAVECIKTGAADYLPKPFNISHLLVKVDKVIRNRQSRQERNRLSNIVRMLNVSNALNAQLDLKSICYEFVSQVQKNFRPDSVVLFLIKEEKNSLVKYVVRGRTLRENPKLFSELKGLGEKSVRESRSFLLDKGNAREYLKADPGKFQHSILISPLYSQHNRVGAVVLLREEDNLFTNEDLQLLGVFAAHAATAMQNARMYGKMRDKNLDIIRSYAKAVEAKDYYTKGHSERVAVYAMKLGSRLKLDSKELEDLYTAGVLHDIGKIGIPDHILNKPSQLTDEEFRVMQSHPGIARDILAQLWSLNDILPVVYHHHERVDGGGYPESLSNGQIPFLAKLISVVDAFEAMTSDRAYRDALTWEKARDILEQGSGTQWEDELVQEWIKLVQETGLENIQKDIQSSPAAFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQX3</accession>
    <name>D6SQX3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2545"/>
    <dbReference type="EnsemblBacteria" id="EFI35149">
        <property type="protein sequence ID" value="EFI35149"/>
        <property type="gene ID" value="Dthio_PD2545"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033IHH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="47" mass="5316" checksum="7701CD486DABAE44" modified="2010-08-10" version="1">MGVRSILYFLARILGDINAVRKNRIGRRIGRRAAGKATGRIFRGIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR51</accession>
    <name>D6SR51_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870525.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0490"/>
    <dbReference type="EnsemblBacteria" id="EFI33167">
        <property type="protein sequence ID" value="EFI33167"/>
        <property type="gene ID" value="Dthio_PD0490"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1654434at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="137"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="334" mass="38189" checksum="A286302BCA66627B" modified="2010-08-10" version="1">MTKSAARAIATHIINYTQNNDQATNNHLLKIFKRIYANGGLFRYFQNRNLKKTTWYKYKAAYQYGASLLIRSLLKEADKLEKTDKTKVKLYREEALRLGEDLKKLSPDYEKQHRLNPPAPGNQPKPYKKDKISGKRKALRGLPSNWVGQLIDELPIQHQDAALIMALTGCRPAELEKGVWLETVDHDHLKVTIKGAKYIKNKQGQKQRVLKFALEDAHRLFNLAYEEPRLVWINKEAFRKAIRRAADNLGFKGVSPYSLRHQFAANLKSESGKKWTHEDLAKALGHITDRCQQFYGHPNQARGRGSGILAVQASTSIKNNRGVIPTPQPETNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR71</accession>
    <name>D6SR71_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870545.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0513"/>
    <dbReference type="EnsemblBacteria" id="EFI33187">
        <property type="protein sequence ID" value="EFI33187"/>
        <property type="gene ID" value="Dthio_PD0513"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TNY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1950808at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DUF1992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1992" evidence="1">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="125" mass="14702" checksum="E09E7AA31ADF92CE" modified="2010-08-10" version="1">MDIFAQKAEERILEALKKGDFENLPGRGKPLDLADDSNIPSDMRIAYKILKNAGYAPPEVELQKEIATTRELLENSREEEEAYRRIQKLNLMVTRMNIMRKRPVNLEEHQEYYQKIVNKVQINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRC0</accession>
    <name>D6SRC0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870594.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0562"/>
    <dbReference type="EnsemblBacteria" id="EFI33236">
        <property type="protein sequence ID" value="EFI33236"/>
        <property type="gene ID" value="Dthio_PD0562"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033D23">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2092374at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="61" mass="6999" checksum="D1FB47DDC82788A6" modified="2010-08-10" version="1">MDQAEKQAVQVTKEIVVKFIEVGRISPGNFHEFFSPIYKEVLDTIRSKQEQNGQKEEESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRC5</accession>
    <name>D6SRC5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trans-hexaprenyltranstransferase</fullName>
            <ecNumber evidence="3">2.5.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.30" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870599.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0567"/>
    <dbReference type="EnsemblBacteria" id="EFI33241">
        <property type="protein sequence ID" value="EFI33241"/>
        <property type="gene ID" value="Dthio_PD0567"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036422">
        <property type="term" value="F:heptaprenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="322" mass="35823" checksum="03D91560AA85BB7C" modified="2010-08-10" version="1">MSKLSDFFSRELPRINATLEQELAQLNPLVKEVGEHILLSGGKRLRPMLTILTARCLGYQDQDIYPLACSLEFLHSATLIHDDILDSADTRRGQTACHLAFGLHRTVLAGDALLALANLIVARYDIPAMNYCVAQAIMRTATGEVEEIAQIRSPRPDRTAYLEIIQGKTADLIRAACSCGAMLARADQERLDHADSFGFNVGMAFQLVDDALDYAADHELLGKPLGGDLREGKITLPLILYLQTLQKDQQGEILHKMAHDLLCDHEMQQIIGQIQEMGLDTKVREEAGKYLQLAGQALESFPDAPEKYLLQEIVEVVRSRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRE4</accession>
    <name>D6SRE4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB proton channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870618.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0586"/>
    <dbReference type="EnsemblBacteria" id="EFI33260">
        <property type="protein sequence ID" value="EFI33260"/>
        <property type="gene ID" value="Dthio_PD0586"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="105"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="234" mass="26257" checksum="2292D2579CEFC9C4" modified="2010-08-10" version="1">MDIFLPEQGLWSMLAQASLLIQFIMLVLLVMSVSSWTIIIYKFISYRRFTENLGNQLQIFDRASDLAEAMKKVRQDADSPLYRIGFSALKEIQKLEQSQLSSSVKFRIAEDNVRRVLRQGVSTHLKKLASSLPFLAICANSSLLIGLLGTVWGIMNAFHAIGVQRGASLATVAPGISEALITTAFGLVVAIPATIFYNILWERLNSIQADLIYFAGAFLNRAQRELPWMEKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRF6</accession>
    <name>D6SRF6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein Dthio_PD0598</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870630.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0598"/>
    <dbReference type="EnsemblBacteria" id="EFI33272">
        <property type="protein sequence ID" value="EFI33272"/>
        <property type="gene ID" value="Dthio_PD0598"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="249" mass="27360" checksum="C038B8F2D27AAADB" modified="2010-08-10" version="1">MAGHSKWHNIQHRKGRQDAKKGKIFTKVTKEIMLAARDGGGEPDKNPRLRAAIDSAKSANLPKDKIETAIKKGTGELAADQIEESVCEGYGPGGVAMLVQIATDNKNRTVAEVRHLLSKNGGSMGESGCVAWMFDHKGVLSFDKESYSEEQLLEVGLEAGAEDIIDDGEVWQVRCAPEDFTPLQQAYQEAGMEVSEAELTMVPQNTVGVDPETGRKVLKLYDALDDLDDVQNIYTNFELPQELLQELEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRF9</accession>
    <name>D6SRF9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YCII-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870633.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0601"/>
    <dbReference type="EnsemblBacteria" id="EFI33275">
        <property type="protein sequence ID" value="EFI33275"/>
        <property type="gene ID" value="Dthio_PD0601"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="10247" checksum="7AFACC7868E08AE0" modified="2010-08-10" version="1">MVVFIGKDRPGGLETRKAQREKHVAMLKDLQDRGLIHFAGPLLDDQGEMNGSLIIFDTEDVEKVNSIMDQDPYVKAGLFASREAMRVKKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRJ0</accession>
    <name>D6SRJ0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870664.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0633"/>
    <dbReference type="EnsemblBacteria" id="EFI33306">
        <property type="protein sequence ID" value="EFI33306"/>
        <property type="gene ID" value="Dthio_PD0633"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="393" mass="43338" checksum="12A3A310D035ED56" modified="2010-08-10" version="1">MNFSKRVLSIQPSATLAINAKAQEMRAEGENVISLAVGEPDFSTPDHIVTAAKEALDKGFTRYTAVPGMPELRRAVAGYFSRTYGIECTQNEVIVSNGGKQCLYNLLQALVDPGDEVLIPGPYWVSYPDMVQLAEGAAVIVPTEPEDNFLVKKEDLEKYVTSRTRVLILNTPSNPTGCHYSQAQLEDIARWAVSRDIFVICDEVYDQLVYPPAEMSSLCSFWKKHPDGVAVVNGLSKTFSMTGWRIGYILAHEDLIKAMSKIQGQSTSNVCSFAQKGALAGLEGSFEMVETMRDSFARRRDLALEIIGSWKDAVCPRPDGAFYLFPRVDAFYNDRVDSSTELCKAVLEKEKIALVPGKAFGDDRCVRISYAVGDEVLQDCLQRLGGFLAGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRK5</accession>
    <name>D6SRK5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870679.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0648"/>
    <dbReference type="EnsemblBacteria" id="EFI33321">
        <property type="protein sequence ID" value="EFI33321"/>
        <property type="gene ID" value="Dthio_PD0648"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="74"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="282" mass="32330" checksum="25C6573502F96EF2" modified="2010-08-10" version="1">MSDNQESVIKTCKSYYDSHDACIFYTEVWGGEEHHLGIYRRPEDTLYEASKRTIDRMASYSRNLKELKDKARVLDLGSGYGGTARHLAKTFGCRVVGLNLSETENNRHREMNREQGLDHLIEVVDGNFENVPYEDNSFDVAWSQDAFLHSPDRKKVLGEAARVIKPGGELIFTDPMQTEDAYAEYLDPILKRIHLTSMATPTFYIQAAQEAGLKLKSFENLQVQLANHYAKVLEDTIKMEDELRKKDVSQEYLDNMKKGLQHWSTGGKHGHLTWAIFCFEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRN1</accession>
    <name>D6SRN1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUA5/yciO/yrdC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0675"/>
    <dbReference type="EnsemblBacteria" id="EFI33347">
        <property type="protein sequence ID" value="EFI33347"/>
        <property type="gene ID" value="Dthio_PD0675"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="212" mass="23172" checksum="C864F385612E6657" modified="2010-08-10" version="1">MEFNMSGSIFQAVQIIKSEKILIYPTETLWGMGGTGTSKAVVQKIRELKKRPVHKPFPLIAGTLEQARSFVAMDPESLELAGQFWPGPVSILCRALDMLAPGVRDEQGMVSIRVTPHQDAARLCLDAGTPLIATSANISGEKSCAVFEELDSELLRKVDMVFEHGHAPAGGLPSTLVRVFGGGKIEILREGRISRQDLESRGWETVYKTDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRV8</accession>
    <name>D6SRV8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0758"/>
    <dbReference type="EnsemblBacteria" id="EFI33424">
        <property type="protein sequence ID" value="EFI33424"/>
        <property type="gene ID" value="Dthio_PD0758"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="8798" checksum="1046D0A89743CA85" modified="2010-08-10" version="1">MDGIIIRDNGICGGEPVFVGTRVTLRTILASLAEGATVGDILSDFPSLTEEHLWAAIRFAAASAEEDLPVQQVPTFFHENQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRZ4</accession>
    <name>D6SRZ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870812.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0794"/>
    <dbReference type="EnsemblBacteria" id="EFI33460">
        <property type="protein sequence ID" value="EFI33460"/>
        <property type="gene ID" value="Dthio_PD0794"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9572" checksum="40CE09227E88ABE2" modified="2010-08-10" version="1">MEFKQKLKQTLIRELNLEDIHPEDIQDDAPMFGDGLGLDSLDAVELVVIVQKHFGVEIKDMEEGQTAFQSINALSAFIQERKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRZ8</accession>
    <name>D6SRZ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0798"/>
    <dbReference type="EnsemblBacteria" id="EFI33464">
        <property type="protein sequence ID" value="EFI33464"/>
        <property type="gene ID" value="Dthio_PD0798"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023969">
        <property type="entry name" value="CHP04072_B12-bd/rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04072">
        <property type="entry name" value="rSAM_ladder_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="176"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="455" mass="50975" checksum="6473B623FDADD14C" modified="2010-08-10" version="1">MKVFLLSTNTSLEPYPVYPQGMAMIASALSNAGHEVKQFDYLVSNESEELLGKEVLEFAPGVVGVSLRNIDNVDSFSDQSRWFLEQTRRIIDSLREITRAPIVVGGPAFSIMPEAILEYLGADFGVEGEGEAAVVKLLERIQNNGHGPRIVRSKEVLHKSQLCSPLVDKDILEYYNKESGLPGLQTKRGCPHSCVYCSYPSLEGPFLRARHPEEVVEDVAKLSRDHGVEHIFFTDSVFNDCRGHYLELALALARRNLPVRWSAFFRPDPIRDDDLDLLLHSGLLGMEVGSDSCAEPTLEGLGKGFCSSDVLRFNAACVRRGIPVAHYFIIGGPNETEATIRETLSNIGKLEDCVAFVYSGLRILPGTKLHAHAIKEGILDESTSLLRPVYYHSPGIERDRMHEIAAKALDGCRNCFFPPQEAQDRMNVMRRFGYRGLIWDKLIEAEKKRTRRVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS19</accession>
    <name>D6SS19_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0819"/>
    <dbReference type="EnsemblBacteria" id="EFI33485">
        <property type="protein sequence ID" value="EFI33485"/>
        <property type="gene ID" value="Dthio_PD0819"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="358" mass="37877" checksum="21BB2C96ADCDAD35" modified="2010-08-10" version="1">MPVYIRGIGVLGSFGTGVHDLRKALEEDRAAETSFTSHDLDNAQKDLPVATADTGALGRYLPRKVLRRIDHYSRMAVLGSFLALEDAGMLDNPRERMGIVIATSYGAAATTFSFLDSVINDGDACASPTYFSNSVHNAAAAHISILLNITGPSLTVSQFELSVSSGLITARQWLLENRVDYVLFGAVDEYCALRGYSWLRLCVPGSKDISGNLAGDDQGSVMGEGAAFFLLSSEKTVDDYGCITDIQQGRWHECSLSFSGPAPLILNSGSELACKSNADLIPGQSSQGAAHAHIFGGLPASQAFDLAVAGLKIQQGQLFPCSEEPGTSIAENCMQQDPGIVCLQIGKGGDFGAVTLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS34</accession>
    <name>D6SS34_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="5" type="ORF">Dthio_PD0834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870852.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0834"/>
    <dbReference type="EnsemblBacteria" id="EFI33500">
        <property type="protein sequence ID" value="EFI33500"/>
        <property type="gene ID" value="Dthio_PD0834"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1349288at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="267" mass="28249" checksum="B522DC91CB1644AE" modified="2010-08-10" version="1">MKARLGLIGTGNMGGAMVQGLAHRQDLELHGYDPDKSCLERLGRECGLKQQPGPAELARDCDYVVLAVKPGLAPAVAAEISSSLDRSKCLISVAAGVKTGDLAFWSNKACPVVRVMPNTPALVGRGVFALCLEDDTLSPEQAGFIQGLFQDLGQVHVLPEKSFDAFTALIGSGPAYVYYFMESMVDAGVYMGLGRAQATEMVLELFAGSAHMAHKEKCHITQLKEMVTSPGGTTTAGLGALEKRAVKAAVLKAVQEAARRSRELGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS63</accession>
    <name>D6SS63_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Replicative DNA helicase</fullName>
            <ecNumber evidence="4 16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Dthio_PD0863</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 16"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870879.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0863"/>
    <dbReference type="MEROPS" id="N10.002"/>
    <dbReference type="EnsemblBacteria" id="EFI33529">
        <property type="protein sequence ID" value="EFI33529"/>
        <property type="gene ID" value="Dthio_PD0863"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1709134at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 16 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 16" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SF4 helicase" evidence="20">
        <location>
            <begin position="224"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="19">
        <location>
            <begin position="538"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="18">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="SF4 helicase" evidence="20">
        <location>
            <begin position="853"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFI33529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="925" mass="103359" checksum="88EEC5CA0702D404" modified="2010-08-10" version="1">MTANKSPGSQGKNPEGSAHSGSGRSFKGKDASKRSGQDLSQSLGKVSSDLVKRMPPQNLEAEQAVLGGVFLSNEVLHTLVDVLSEEDFYSPAHRIVFRTFLELYRRNTPVDLVTVHEELEKTSQLESIGGAVYLASLTEAVAASANVHFYAQIVKEKSVRRHLIQAATNIIAQSFEPASEISDLLDTSEQSIFAISEAKTKPVFRSTKDLVEDVFKLLEQRVERKELVTGVSTGYHKLDEITAGFQPTDLIICAGRPSMGKTAFALNMAMRSAVAHGVKTAVFSLEMSMEQLMMRMLCSWGKVDLKNLRTGFLNDEDWTRLHQAAQALSRAPIYIDDTPALSSMEMRARSRRLKSEKGLDQVVVDYLQLMRAGRFIDSREQEISEISRSLKALAKELNVPVVALSQLNRKVEDRTNKRPVLSDLRECVTGDTLVCLADGCRIPISELVGTTPKVIAMNRQGKLVNARSDLVWPVGRRNILEVKLASGRILRVTADHRLYSAGGWCRVATLKQGDRLAIARQLPEPENDLVWPDRRVALLAHLIGDGSYLKGQPLRYTTADESSSHLVEEAATQEFNVRVNRHYPQKGAWHQLVFSGNGNRWRPAGLNLWLRELGIFNQRSHEKRIPREVFRLGNRQIFLFLQHLWATDGTVYSRREGLRGSHAIHFSTNSPGLAADVSALLLRCGIISRTQTVHQAGSRPWRMVHVSGSTQQRLFLEKIGGFGPRRREQVQKLAAELAATRPNPNVDTLPRELFNHVRAAMSDQGITHRQMTAMRGTSYGGNSHFRFAPSRRILHEYAEILDDDLLRAHCKNDLFWDTVVAVEPAGQEEVYDLTVPEQASWLADGIISHNSGAIEQDADVILFLYRDGVYNPKEDNPRRDVAEVIIGKQRNGPVGTVELSYLDRFTAFENLTHVPAPSEEEAQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS69</accession>
    <name>D6SS69_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LPS-assembly protein LptD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lptD</name>
        <name evidence="3" type="ORF">Dthio_PD0869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the lipopolysaccharide transport and assembly complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LptD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870885.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0869"/>
    <dbReference type="EnsemblBacteria" id="EFI33535">
        <property type="protein sequence ID" value="EFI33535"/>
        <property type="gene ID" value="Dthio_PD0869"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="100018at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010033">
        <property type="term" value="P:response to organic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01411">
        <property type="entry name" value="LPS_assembly_LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020889">
        <property type="entry name" value="LipoPS_assembly_LptD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007543">
        <property type="entry name" value="LptD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04453">
        <property type="entry name" value="LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009009750" description="LPS-assembly protein LptD" evidence="1">
        <location>
            <begin position="26"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="LptD" evidence="2">
        <location>
            <begin position="287"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="758" mass="90528" checksum="0209A32900B59C46" modified="2010-08-10" version="1" precursor="true">MLYKINLAFFIFLAGMLLIAGCSWASDEPWELEADQMYVDQEKNLVEAFGNVLMWRMDDYVQADYARLHTDTNWIYLKGNIQARFEGDHIEGREAELDLDNHVGWIKEGKVFMAQDNVYFSGERMEKTGPHTYTYEDGIMTSCDDRPAPWSIKSSRGEVTVEGYARLWHPRFRVKDRPILYSPYMIAPVKTKRQSGFLFPTFGQGSEYGFNFNLPYYHVIDDQRDMTFYANYYTDRGFMPGVEYRHTPRLHRKGLWRADWLRDRQVHDQGNEPSRFEDDGLFRPNRDRYWIRGKYDHYDPATDWTFRLDVDYVSDQNYLREFSDGHSGYYASRDEFEDEFGRDIQGKDRLRRNNIFSASRNWNNLGFNTRLVYTDNLEYRNRNKPARRNPTVQRLPEVNLDLYRTRLGDSPFELESSNEGVYFWREYGTTATRLDVHPRLSMPIRSGWGRIIPSAGWRQTGYFVDSFQDEPVERDTDSRFQTRGIYDFNIRADTELQRIFEMGPAPEVKWGSVGESAWTGVKHSMLPELEFDYIPDKDQDKYPSFDSTDRIAAREELTYSLRNIFTRRLERVRQGTDEGEPVLSKDYRNFLRVELEQSYDFREARRSHSREYNRRPFSDLLAEISFNPNQYITLSNKTWYSFYETMVTEHEHTLTLTWPDVASTWFSLDFLNEIDEYKRTVDERINILEVGMDLDYFRKWRFEASMKRDMEHSRALENRLSAEYRHQCYGFMFEYKKTDYDHSFAFHIKLLNLGEWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSD1</accession>
    <name>D6SSD1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-type ATPase subunit delta</fullName>
            <shortName evidence="7">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpH</name>
        <name evidence="8" type="ORF">Dthio_PD0932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870947.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0932"/>
    <dbReference type="EnsemblBacteria" id="EFI33597">
        <property type="protein sequence ID" value="EFI33597"/>
        <property type="gene ID" value="Dthio_PD0932"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937493at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="183" mass="20231" checksum="CBE043D5E3C112AD" modified="2010-08-10" version="1">MIGNIVARRYARALFALGQKQGDKELKAYGDDLASIADVLEGSPELFRIFRNPVISVSEKKGILTKVLGKLKPSKTISNFCHLLADKGRLDHLTEIQVYYAKLLDDYQGVLRGEIVTAIKLADNLKQDIVGKLEKQSGQQVTLDYKVDPEIVGGLVLKVGDKVLDASIKAQLQILKENIKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSD3</accession>
    <name>D6SSD3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="16" type="ORF">Dthio_PD0934</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870949.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0934"/>
    <dbReference type="EnsemblBacteria" id="EFI33599">
        <property type="protein sequence ID" value="EFI33599"/>
        <property type="gene ID" value="Dthio_PD0934"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1999641at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="45"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFI33599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="140" mass="16096" checksum="CC01AE91424C03AF" modified="2010-08-10" version="1">MIDLDITFFIQLVNFFIVLLLLNLILYKPIRGMLRKRAEIMNQKVEDVESFNSRADEKLKTYEKELEMARLKAQELRQEKKNEGLDTEKQIVQAASDEASSILQSAREKARKEKESALTALKKQVDKFAGHAADRILGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSL8</accession>
    <name>D6SSL8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate dehydrogenase gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871033.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1022"/>
    <dbReference type="EnsemblBacteria" id="EFI33684">
        <property type="protein sequence ID" value="EFI33684"/>
        <property type="gene ID" value="Dthio_PD1022"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1612137at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="223" mass="25131" checksum="6154319D77DDD6FC" modified="2010-08-10" version="1">MQQNNNEIVLERFNARRRLVHWIHAAAFFVLLGTGLTYVTPGLTFLAEGGIPGTLHRIFAVVFLAVPLIYLVIDPKGFREFVRDSLNFEKSDIGFHLRMPYYILGKTQGIPPQGKLNAGHKMHHIFMGILFVTLGVSGLIKWFGVGHMGPAMLNLMGTVHIISVFVITIMTLGHVYFTVVYWAIPSMIHGKVTESYVKLEHRKWWDEELAPKVKGSSEKSQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSN4</accession>
    <name>D6SSN4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/carnitine/betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871049.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33700">
        <property type="protein sequence ID" value="EFI33700"/>
        <property type="gene ID" value="Dthio_PD1039"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1217683at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018093">
        <property type="entry name" value="BCCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01303">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="498" mass="54770" checksum="5DB89B2B94B3F8BE" modified="2010-08-10" version="1">MTLKNNIVFVISLLAILVVILAGIFSADALDRWSAWLHGEIISNFGWFYLIATFVFLVFSLYMALSKYGHIKLGMDHEKPRFSYFGWASMLFAAGMGIGLIFWSVAEPMSHYMSPPGFIEPNTPEAARFAMLHSFFHWGVHPWAVYIVMSLCIAYFSFRRGMPPLISSCFYPLIGDRINGFAGYLIDILAVFATVFGIVTSLGLGAMQINSGLASILPFEADIFSTLIIIGIITVIFMGSSMAGLDKGMQIMSKGNVMLAVLLLAIMLVLGPTNMILNIFISTTSDYITALFNISLTANPFIGLEWTQDWTLFYWAWWISWSPFVGLFIASISRGRTIREFITGALLIPTGLTFVWFSVFGGTAFSLELGNNAGIAAAVAHDVSTGLFQLYAFYPLSEILTLITILLLVIFFVTSADAATFVLSLMTSRGMADPPTGKKIIWGLTVSVTAAILLLAGGLEGLQRMAIAAALPFSAIMLLMCACLLKGLRYEFRYERKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSQ0</accession>
    <name>D6SSQ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871065.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1055"/>
    <dbReference type="EnsemblBacteria" id="EFI33716">
        <property type="protein sequence ID" value="EFI33716"/>
        <property type="gene ID" value="Dthio_PD1055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1175945at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="298"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="392" mass="45479" checksum="7270B4C0CA76467F" modified="2010-08-10" version="1">MVQNSDAERSAVPERDKELREREYQAYQLRLLNEYLRELFFLEDRGEIAEQFLLMCMGAVGTDKALLLVFDEQEESALHYRGFNDFRVQRLREDAFVQAQQHLARDDRDNELLPKQILVISTNEHEAARDSRLPWPEDSCFIVRWNLDSGCFGYLVLGPKLDGSIYFDLDRDFLLQLSQVLMDSLQMVRSREEIHRLNADLMSKNQELSQTIEELQKSHETISILQRTRDRLHGLIHSEAARLERVSAWDFVFIVAVTLIISLLYNTTSPGGVSLTPATWSLPEPEMIDTDRAAEIYEQDGAVFVDARPNQFFEQEKIRDAVNLPSNLFDFIYMMHFAQLDPEKKIIVYGRNISRRYDETVAFELEERGHERVLVMPGGLGEWKAKGMPVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSR4</accession>
    <name>D6SSR4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871079.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1069"/>
    <dbReference type="EnsemblBacteria" id="EFI33730">
        <property type="protein sequence ID" value="EFI33730"/>
        <property type="gene ID" value="Dthio_PD1069"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="259"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="476" mass="53866" checksum="59F2745C934B7164" modified="2010-08-10" version="1">MFTDMEADLKLKDVSVLCVEDESFTLEFLTQMLGPRVKEVHQARDGQEGLYAFSRFNPDIVITDIEMPRMDGLEMAEAIREQDPEAVVILSTSFDNIDNLKKAIALRLDEFVSKPVAPAELLEVLQRCLRVISRKKAKDRQRRTMEVMLGGMPFPVMLLDTENHRVEIANPEAGRAGYRQGAALEGRFFPPEVRQVIKSKGNAGDLIEAREQSRLEISSGDKNWEIYLKPVASGWMVAAVVDVTWRWHLDQLREDVERITRHDMKTPLNGIIAIPDLLLESDALDDESRELVQYIKESGHTLLNMINLSLDLYKMEQGTYQLDPGKVDLTRVLRQVLRQLEPLSRGKNIQVRLLHQDMDVPDDFSFMVCGEEMLCYSMFSNLIKNALEASPQGKEVSIKMRHQAGESLITIHNHGEVPREIREVFFDKLSTHGKKSGTGLGTYSAALIARTQNGNIDMQTSVESGTTLTVRLPLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSS6</accession>
    <name>D6SSS6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1081"/>
    <dbReference type="EnsemblBacteria" id="EFI33742">
        <property type="protein sequence ID" value="EFI33742"/>
        <property type="gene ID" value="Dthio_PD1081"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="6">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="315"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="5">
        <location>
            <begin position="565"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="697" mass="76912" checksum="E5E93E86FFA4473D" modified="2010-08-10" version="1">MNSQMMSDKEQMQQAFLEEAGDLLPELEAALLELDNAPSEPELINRVFRALHTIKGSGSMFGFEEVADFTHEVENAFELVRCGEMAVSKELLDLTFRAKDQIQLMLQDSAAKDSQGVQEILESVRELLPVKKQEAGESPKQEKQSQTSRENLAYRIRFKPDQNILAMGTDPMMLLDELRELGQAYVIAHSEDIPALEKLDPEKCFVWWDVILITTQGKNAIHDVFIFVEEDSELSIQIVDHVSGYGQEEGYRKLGEILTERGDLSRQDLEAALGSQKRVGELLVQAGLVSRTQVESALAEQQTMRRVQEDCSKDVSASSVRVPALKLDELVNLVGELVIAQSKLSRMVGDDGNMALRSIAEEIERLSDELRDNTLGIRMLPIGSSFGKFRRVVRDLCSQKGKEIELVTEGADTELDKTVIERINDPLVHLLRNSIDHGIESPEERAKLGKPRQGTITFSAAQSGGNVILTISDDGRGMDSERIKAKALEKGIISQGDELGQRELLNLIFQPGFSTSTEISDISGRGVGMDVVRKNISALRGSVDAESIPGEGSTIRISLPLTLAIIDGLQVRVGEQHFIIPLSVVGECIELEGNAQRGEANWDFVRLRDQLIPYISLRKFFEVQGEAGSIEQVVVVDTGEKLMGLVVDEVLGQQQTVIKNLSRVYQHIREVSGATILGDGSIALILDVSRLGEMAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSU0</accession>
    <name>D6SSU0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FolC bifunctional protein</fullName>
            <ecNumber evidence="5">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871105.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1095"/>
    <dbReference type="EnsemblBacteria" id="EFI33756">
        <property type="protein sequence ID" value="EFI33756"/>
        <property type="gene ID" value="Dthio_PD1095"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_C" evidence="4">
        <location>
            <begin position="290"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="428" mass="47400" checksum="FD1A559F800096A3" modified="2010-08-10" version="1">MYKFNDFSVLQEYLDHLGLFRMELGLERMQKALQRVDFRPGEPYLVQIIGTNGKGSTASYLESLARMHGLKTGIFTSPHLVSVKERALVNGKKLPDKAWLKAANLLDGSCGDLELTYFEFLTLAAVLMFRDAGVDLGVMEAGLGGRYDATTTLEAGLQVYTCIDMDHTSILGETIEEIARDKAMAVRADSTVVLARQNYPQAAETVQSTASGVGSSLYRVQDFFVQKDAGTYFTGEPDFFVGTDVPGIHGDYQLQNAETALVAWRILSRRFDLKMDPQKCLQALQDTFLPGRMHVVSRDPLIILDGAHNPGAMDRVHSFLGGLAIRPGHIVFTCLSDKEIEPMLQMLRRFYPARVLVPDMGSGPRSMDRQELLSMMGDGAKPLDDLEGFLKGLAPGDDPVLVCGSLYLLGHVYRLFPEWMKKKGIALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSV9</accession>
    <name>D6SSV9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1114"/>
    <dbReference type="EnsemblBacteria" id="EFI33775">
        <property type="protein sequence ID" value="EFI33775"/>
        <property type="gene ID" value="Dthio_PD1114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="54" mass="5913" checksum="8D2EBC8643E8B9E1" modified="2010-08-10" version="1">MDASAKSQSGRADHANHARRVAGGLADRRVKELTVMEASFNCLGFEFMPAHFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSX0</accession>
    <name>D6SSX0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871135.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1125"/>
    <dbReference type="EnsemblBacteria" id="EFI33786">
        <property type="protein sequence ID" value="EFI33786"/>
        <property type="gene ID" value="Dthio_PD1125"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9457" checksum="435B2EFB3A8B2E52" modified="2010-08-10" version="1">MSQEVKIFALSTCIHCKKAKEYLDQCSVKYTPVHVDWLTGEERNNTLAELKKYNPAASFPTILVGDRVIVGFRKDELDQALGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST69</accession>
    <name>D6ST69_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiD</name>
        <name evidence="6" type="ORF">Dthio_PD1224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1224"/>
    <dbReference type="EnsemblBacteria" id="EFI33885">
        <property type="protein sequence ID" value="EFI33885"/>
        <property type="gene ID" value="Dthio_PD1224"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="392" mass="42362" checksum="037A4BA2D07DA895" modified="2010-08-10" version="1">MQDLPAYEYQRFTICRKTMSRKKARRLRSGFTTGTAAAASTMAAAGLLLQGTCPGQVRVRLITGDDLEIPVHACGIDCKDFAWCSVIKDAGDDPDVTNKAEIGARVSRLENTDEISICAGEGVGHITKPGLELAPGEPAINPGPRHMIRENLEKVLQETGVQHGLQVEVFVPRGEEIARRTLNHRLGITGGISILGTTGVVRPMSHAAYIATIDSALSVARACGLDRVVCTTGRRSERFAQEIFPELAEEGFVQIGDYFAESMKRAARKGHKEAILVVFFGKAVKMAQGAPHTHAARSRLALEDLGRMVLEICSAAELSQRVAGANTAREAFFMLQDECPEIFERVVQLMAEQARAFAGGGINVRAVLLDFEGRVTADSSGALKQISTREMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST91</accession>
    <name>D6ST91_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33907">
        <property type="protein sequence ID" value="EFI33907"/>
        <property type="gene ID" value="Dthio_PD1246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="48" mass="5718" checksum="A7BE7F716CD7DCD6" modified="2010-08-10" version="1">MRVAMQGSTQAGIRKKSRVKKNLLLYNFSNNIQIIMIKRKILWQIKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6STC1</accession>
    <name>D6STC1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871286.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1276"/>
    <dbReference type="EnsemblBacteria" id="EFI33937">
        <property type="protein sequence ID" value="EFI33937"/>
        <property type="gene ID" value="Dthio_PD1276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745382at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022452">
        <property type="entry name" value="MqsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025272">
        <property type="entry name" value="SocA_Panacea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13274">
        <property type="entry name" value="DUF4065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03830">
        <property type="entry name" value="CxxCG_CxxCG_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="272" mass="30613" checksum="1281CEC7AB4AADF7" modified="2010-08-10" version="1">MQEHKCPACSSLMEFKELKKKKVFKGLDIEYSGNFFVCPGCSLEAGDAGSAGEVQRAIADAYREKAGLLTGQEIRELRDSKGLTQEQLSRALNVGVASIKRWESGMVQSRSMDGLLRRQLKPEPNPYTGNRETSLPRIKLVAQTLEKILSRQLLKEGDRFLFLGKYLWYADMLAFRRSGQGLTGASYAALPYGPQLNNYRDLVEPINNSDIADAEPLSREEHAVIHYIAECFPYDRDIYDASHKEKVWYDAPAGSLISYLCAYELTQIPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6STD8</accession>
    <name>D6STD8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formate dehydrogenase accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871303.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1293"/>
    <dbReference type="EnsemblBacteria" id="EFI33954">
        <property type="protein sequence ID" value="EFI33954"/>
        <property type="gene ID" value="Dthio_PD1293"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="876348at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16341">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006452">
        <property type="entry name" value="Formate_DH_accessory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37689">
        <property type="entry name" value="PTHR37689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04216">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="295" mass="33736" checksum="38A9BE175FF52D36" modified="2010-08-10" version="1">MFTQPEKSLKIYKKRKKPLEQKSFLPKELTQLVDFIIKNQLEAAEKASPENNPHTSLASSHEVLSGKPLLPREEFPLDFKTSRELALKILKFMADSNEHLVQSMEVIQKEMDSDPEFLDMAMKKYLEGDDDFFRSFGEKTPSAPRSLNFLVQSAAAPSLAKTADSLSLALPAQQTFQSGHCPVCGSLPYIAELREKQGFRYLHCSFCHTAYRFKRMACPYCAVEKSDSFEYFHTREIPGFRVDLCTSCNMYIKTMDFREMDKKALPPLDDLESLPLDIKAKEEGYIRPTLSAWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6STQ6</accession>
    <name>D6STQ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin (Vitamin B12) biosynthesis CbiX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871421.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1411"/>
    <dbReference type="EnsemblBacteria" id="EFI34072">
        <property type="protein sequence ID" value="EFI34072"/>
        <property type="gene ID" value="Dthio_PD1411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1812068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="123" mass="13862" checksum="C31B6C726F22FAFA" modified="2010-08-10" version="1">MSAQALIVLAHGSRNFRANQAFLEMVEKAGQESGEKNIFGAFFSLADPGLEDVVQKLCREGIEKIVVFPYFLLDGSHVEKDIPERVRLIGEKFPRVSFEVLSSLEHEPLMKSIVVDRARRLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6STQ7</accession>
    <name>D6STQ7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1412"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="441" mass="49648" checksum="EEFB20E4FA991795" modified="2010-08-10" version="1">MADAALKLGAEPKETFLDKVRDLLPEQGHLNLCLTCGACSSGCPATGLEGMDPRKFLRMAALGMDEEVTSTPWVWMCTMCTRCVHACPMQINIPQLVFQARKTWPEEKKPRGIVQSCKAAMIDDATSSMGATSEDFVEAVEETLEQVRSQQRGYKDLQVTFDRKGAKYFLNQNSREPMTEPDEMVPLWKIMHEAGADWTYGRAGWAAENYCMFAANDAEWEKIVRIKAEAVDALGCEYWLNTEUGHELYAVRFGLEKFNIPHKFKIESIIRLYADWVREGRIKLSSDWNKDLKIKFTVQDPCNMVRKTFGDSIADDMRYVLKACVGEENFVDTWPNKSNNFCCGGGGGFLQAGLKSARQSYGKVKHDQIMETGAKYVITPCHNCHSQVHDLSHHFEGGYECVHLWTVMALSMGILGPDERAYLDASLSECGINECSLPPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STU6</accession>
    <name>D6STU6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871461.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1453"/>
    <dbReference type="EnsemblBacteria" id="EFI34112">
        <property type="protein sequence ID" value="EFI34112"/>
        <property type="gene ID" value="Dthio_PD1453"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2170543at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10866" checksum="C5CA79DC51E26A45" modified="2010-08-10" version="1">MRTLFDPLKFLQSLRLAVELDSKGQILVHGMRFLEPHKAKQARNALKIYDKLLRMQLDAPSKHMRPSVRKLLALGKVEIREGQYVLPESHGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6STY3</accession>
    <name>D6STY3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871498.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1491"/>
    <dbReference type="EnsemblBacteria" id="EFI34149">
        <property type="protein sequence ID" value="EFI34149"/>
        <property type="gene ID" value="Dthio_PD1491"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="49"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="148" mass="17238" checksum="43B8981F52E511EB" modified="2010-08-10" version="1">MKLYLDLCLFYRSFDDQSNERIKLETNILIILLGYVSTGKAHLVNSFALEFENSKNPKLENKIKVSSLLSYATDYIEYDEKIVTRSITLEKNGIMSMDALHIACAEYANVDYFITCDDKLIKQLKKTMNLKIACYDSIDFIYREIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU24</accession>
    <name>D6SU24_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type III restriction protein res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871807.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0430"/>
    <dbReference type="EnsemblBacteria" id="EFI33115">
        <property type="protein sequence ID" value="EFI33115"/>
        <property type="gene ID" value="Dthio_PD0430"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4997">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16977at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11532">
        <property type="entry name" value="NTP-PPase_COG4997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038735">
        <property type="entry name" value="MSMEG_1276-like_NTP-PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="374"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="584"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="978" mass="112427" checksum="76D5E42E49BF0363" modified="2010-08-10" version="1">MTDHSNSHPIYYYKLVRDKIPSIIREKGHHPAVSSLSGQQWTQAASQKLLEEAYELFTAIANGDKESVLKESSDVLEITLTILKQQNYSFDDLLAELEKRREQRGGFEQGLFLESVDGQFLGARLKQSPGFVCTHLDTNSLLELFRGELERSDKAWIASAFYSPAITNILTSEFERFICKGGEARVILSTMNGFIKPEYLVHLRDYVPELKVKVFHPSEIPFDKHPQRDFHVKAYIFKHRTGKGSAIIGSSNLSQGGFSDNIEWNYYTPGEINLPFYENQTPWEKIVQEFDSLWENQCVHITDDFLDGYRERHRDVFQEREKPDTYGYEGQSSTQWSVLADSSAVYGTSKQSIIEPESIQPNVAQSEALEGLKKLRTRKARSGAVIAATGVGKTYLAAFDFIQSGKDKCLFIAHREDILRKARESFSHVLGPEGLEIFSGRSKDVSYGSKAVFAMIQTLGRQGNMKRFHPREFDYIVMDEFHHAMANTYRKVLDYFQPDFLLGLTATPERMDGRDVLWLCDYNIAYEMRLFQAIDKELLAPFQYFAVHDPTDYAQIAWKRTDYDQEELTMALANDTRTALIANNLKKFLPYQGKIKALAFCSSVDHAHYTANRLTQEHGFEATALVGDSSQEQREKVIARLEKENDPLKVICCVDIFNEGVDIPSLSHVLLLRPTQSFTVFLQQIGRGLRKVQTKDVNKHLVVIDFVGNYRSAHVAPLALAGYTSIEEYIRDSARTRGSKSGMSNPPLGCSVSPDLEVQRIWDSKLREIVPMPRGEQLRDLYDEVVQDLGLISPGLCEFYADPQRADPHAFIKHFGSWIKTKKYFDDLSNTENSLLSTQGESFLEYLEKDLNPVKSYKMVVLKTLLSLKGTSWKIDDIASGFLNYYLQHPEHIYDYDELDKQDNPQKLSLQTVKRHITRMPLYYLSNNNNDWFILDKEKNKFILKVDLVDYWNNQNYKMLVLDRVKYALARYFYRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU38</accession>
    <name>D6SU38_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YecA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871820.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33129">
        <property type="protein sequence ID" value="EFI33129"/>
        <property type="gene ID" value="Dthio_PD0445"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1438224at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011978">
        <property type="entry name" value="UPF0149"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036255">
        <property type="entry name" value="YgfB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03695">
        <property type="entry name" value="UPF0149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101327">
        <property type="entry name" value="SSF101327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02292">
        <property type="entry name" value="ygfB_yecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="202" mass="22894" checksum="518EBC8928094BC4" modified="2010-08-10" version="1">MINSLKSYYKKPSDQELDVLADLLDGMPSAMNIEMMDGFLTALICSPELVMPSTYMQYILGEEHEFETSEQAQKFAGLILRHWNSIVSQLEKNEYFYPVLLESEDGSMGNDWAAGFLSGMHLGGDEWQEYLNDEEKSGVFVPILILANEHDPDPELRPGPIYAHKKIQKIYRINPKSWTSARKFVTRGSPCTQSPVLHICSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU42</accession>
    <name>D6SU42_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871518.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32822">
        <property type="protein sequence ID" value="EFI32822"/>
        <property type="gene ID" value="Dthio_PD0128"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1880276at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11553" checksum="03EB131F4784E9A2" modified="2010-08-10" version="1">MSELRLKAEYPEKASEILFDALTLEKSRLQYSLELSRKRLAEFEKKYNVSSLDFWEKWSAEDLEGQDMEYVKWAGEYRLSSSLLQRIDILDGITHANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU86</accession>
    <name>D6SU86_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0175"/>
    <dbReference type="EnsemblBacteria" id="EFI32866">
        <property type="protein sequence ID" value="EFI32866"/>
        <property type="gene ID" value="Dthio_PD0175"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031IUH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8330" checksum="AC8F56CB7C0A9E77" modified="2010-08-10" version="1">MNHNDTLRPEYPSELIKSGERGKFAKKYREEGTNLVYIEPDLFKFFPDSESVNRALRKYFNEHHSSNTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU98</accession>
    <name>D6SU98_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ORF">Dthio_PD0192</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871571.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0192"/>
    <dbReference type="EnsemblBacteria" id="EFI32878">
        <property type="protein sequence ID" value="EFI32878"/>
        <property type="gene ID" value="Dthio_PD0192"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI32878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="201" mass="21693" checksum="7D3CE83FA88DAEB6" modified="2010-08-10" version="1">MVSIIWLGLCYLLGSLPFGVLVATNFCRIDPRYQGSKNVGATNVARLCGFRYGITVLVLDLLKGFIPVWVAMQFSTSVIFISLTALAVIIGHMYSVFLYGKGGKGVATTVGVFLALSTTVTAWALGICLAIVYLTGYVALGSLALVTAAPVLFLLTGNFGYILVSLIIMALVFWRHEENIHRVLTGQENSWRCSSSEATVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUH1</accession>
    <name>D6SUH1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD0265</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871644.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0265"/>
    <dbReference type="EnsemblBacteria" id="EFI32951">
        <property type="protein sequence ID" value="EFI32951"/>
        <property type="gene ID" value="Dthio_PD0265"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="2"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="357"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI32951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="468" mass="51606" checksum="28AE32BC3AFF5BC4" modified="2010-08-10" version="1">MHTKIIATIGPACNERFMIKRLVEQGVRIFRLNFSHGSAGDFEHIVRNLRSVENELQHGITIMQDLSGPKIRAGELKESPLSINVGDELFMGPSDQMDRHDPYLPFDHREIIKDLKVGDEVRVSDGGLSFEILEKSGQVLKLRSENSGIITSRKGINFPGLKASIAALTTKDREDLAAGLDMGIDAVAMSFVQCPEDVSSAKHVIEKKGRWIPVIAKLERQVAVNRLEEILRIADGIMVARGDLGLECPLSSLPTLQKRIIAACNQAAKPVIVATQMLLSMVSNPMPTRAETTDVANAVLDGTDCLMLSEETAIGEYPVQAVGYMREIAEEAEKFFFELGTSPLEPKKQVSENFIGYNACLLADKIGSKALVAHTDSGATVRLISSCRPRQTIFGLSPRWDTQKFMNFSWGVVPVHISEEPQDHLQRTEKFVENFSGFLSGEDLVITSGHPKPGVESSPTNLLKIYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUJ7</accession>
    <name>D6SUJ7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Dthio_PD0291</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871670.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0291"/>
    <dbReference type="EnsemblBacteria" id="EFI32977">
        <property type="protein sequence ID" value="EFI32977"/>
        <property type="gene ID" value="Dthio_PD0291"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="323"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="572"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="821"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="14">
        <location>
            <begin position="982"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="871"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="8">
        <location>
            <position position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI32977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1079" mass="122421" checksum="FC08EAEA27A68BB9" modified="2010-08-10" version="1">MEFLKEADSEGRLWQFTFDAVPDLIAILDAGHNVVRINRSMADALGVEPWQAQGRKCYELVHGMSRPPDFCPHAKLLCSGNAEQAESWIDNLNGHFHVSTNPLHDSTGRLRGCVHIARDISHHKKIQEELQDRTERMQAVMNSMDSLVYVADMQTHEILFINDYGRKNLGYVTGMKCWEIMQKGASGPCPDCGNHLLLDGQGRPTGTRVREHYNSGEDRWYILRDKAIPWKDGRLVRLQIATDITQEKKDREKQERFKAALDSSADSFFIIDCESMKFLDVNLMACQSLGYSREELLNMGPHDLKPEFTFQDMQEICDSVNEDREQAGLIKTLHRTKDGRDFPVEVSLRTFRQRERDLIIAVARDITEFKKAEDALRYRMKMHRLLVDMSMVFLTAPIDYLEKAVSEALMQVARFTRTDRTYVFAYDFHNQTMTNTHEWCAAGVDPQQHRLQNVPFDMAWEPVRLHSQGSPYYIGDIEEMPDWDPLKTHLQKQDTKALLSVPLKDHFHCYGFLGVDCVRETREWTRAEIDLFVLLAELLVNARHRKSREEELNQARLQAEHATRAKSEFLANMSHEIRTPLNGVIGMSGLLLDTELDSQQRSFAETLKTSAQTLLNLINDILDLSKIEADRLQLETKGFNLETTVKDSAGILNYQAMEKGLKLGYVIHPGVHHCLLGDEGRLSQVLVNLLGNAIKFTSQGQVDLEVSPVQEEADHVRLLFEVHDTGIGIPEEKQDQLFTPFHQLNTSVTRSFGGTGLGLAICKSLVQMMGGEIGVKSSKGRGSTFWFTAGFEKDPAPLDKEAQEKISDPGQASCRPHLDSRILIVEDNPTNQMVARAVLKKLGLTNSTVANNGREALDILARENFDLVLMDCRMPEMDGFEATRRIREGKNSVQNPQVPIVAMTAHAMKGDREKCIQAGMSDYLSKPVQPQELEEIINRQLRPAQGGLKNARQEDTPGLDASSVHDQGHFVEAELAERVMHDEELLQEILQQFIQEAPKRMQNLEKSLHSKNPEQARSYAHALKGISANISARNLSEKAWAMEKAAGAEDMEEMHRLLPEMERELENLITVLKERITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUL4</accession>
    <name>D6SUL4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplO</name>
        <name evidence="8" type="ORF">Dthio_PD0308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871687.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0308"/>
    <dbReference type="EnsemblBacteria" id="EFI32994">
        <property type="protein sequence ID" value="EFI32994"/>
        <property type="gene ID" value="Dthio_PD0308"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="148" mass="16325" checksum="76051F5B17A1316C" modified="2010-08-10" version="1">MNLHEIYPFPEDQKAPKRLGRGNSSGKGKTSGKGHKGQKCRAGASIPAHFEGGQMPLSRRLPKRGFKNRFRQEYCSVNLKQLADHFPSTSEINLEDIYSKKLARKNYPVKILGDGEINFAAQVTAHKFSKTAAEKIVNAGGQVKSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUM9</accession>
    <name>D6SUM9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="7" type="ORF">Dthio_PD0323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871702.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0323"/>
    <dbReference type="EnsemblBacteria" id="EFI33009">
        <property type="protein sequence ID" value="EFI33009"/>
        <property type="gene ID" value="Dthio_PD0323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10801" checksum="20356AD9EF770509" modified="2010-08-10" version="1">MPRSIKKGPFVDDHLLKKVEKAKETRDKKVIKTWSRRSTITPEMVGLTFAVHNGKKFIPVFATENMVGHKMGEFAPTRTFYSHAADRKSKAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUQ0</accession>
    <name>D6SUQ0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="2">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcm</name>
        <name evidence="3" type="ORF">Dthio_PD0344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0344"/>
    <dbReference type="EnsemblBacteria" id="EFI33030">
        <property type="protein sequence ID" value="EFI33030"/>
        <property type="gene ID" value="Dthio_PD0344"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="214" mass="23956" checksum="D3851052FF0FABE7" modified="2010-08-10" version="1">MSVDPKRVREKMVREQIEARGIKDEEVLRAMRRVPRHMFVDEALQAQAYADHPLPIGHGQTISQPYVVAMMSAMLEVKPGMKVLEIGTGSGYQAAVLAEMGADVYTVERIKALYQAARQRFNQLKYLYVKTKLDDGTAGWPEQAPFDRILVTAGGPEVPAPLMEQLDDPGILVIPVGESKRHQQLLRVIKDRGEIKRENMGSVAFVDLVGKFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUS5</accession>
    <name>D6SUS5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871748.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0369"/>
    <dbReference type="EnsemblBacteria" id="EFI33055">
        <property type="protein sequence ID" value="EFI33055"/>
        <property type="gene ID" value="Dthio_PD0369"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="383" mass="40493" checksum="C3BEF2CDF579C855" modified="2010-08-10" version="1">MADFLCPAVNFIGRGTVSEIGSRAKMFGTKALMVCDPDLVKIAGGPVDTVKASLESFGIKFAVFDGFEPNPKDTNIADGLKVYNSESCDMIVTVGGGSTHDCGKGIGIAATHEGDLFDNYAGIETLNNELPPVLSVNTTAGTGSEVTRHCVITNTAKKVKFVIVSWRNLPKVSINDPDLMVGKPPALTAATGMDALTHAVECYVTKDPNENADALALHSIKLIGKYLRRAVANGQDMQAREGMAYASLQAGMAFNNAGLGYVHAMAHQLGGLLDLPHGIANAVLLPHVERYNLMVNPEKFAEIAAALGENTCGLGQIEAAEKAIDAIQRLSRDVGIPQGLSELGVKESDIEPMARQAMQDGNAGTNPRVGTVEDIIQLFKNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUT3</accession>
    <name>D6SUT3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PrcB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871756.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0377"/>
    <dbReference type="EnsemblBacteria" id="EFI33063">
        <property type="protein sequence ID" value="EFI33063"/>
        <property type="gene ID" value="Dthio_PD0377"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1104553at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025748">
        <property type="entry name" value="PrcB_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14343">
        <property type="entry name" value="PrcB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PrcB_C" evidence="1">
        <location>
            <begin position="89"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="162" mass="17698" checksum="F6C12C58A114EED0" modified="2010-08-10" version="1">MMQTISSPGGFHSSILLAVSLFLLSGLISCSQDGQDALSAEIAHQWSGHYAEIKIPAAMAGDRENWQEVWSLLRESRPEWPEKTGAFAVFYAGQRPTGGYRMEVEITHQDSDVIRLQCSLHPPDGPATTALTFPWKVVALSGVEGREVQVRHCGSPLAEPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUW8</accession>
    <name>D6SUW8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32724">
        <property type="protein sequence ID" value="EFI32724"/>
        <property type="gene ID" value="Dthio_PD0007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="68" mass="7929" checksum="2791670792123254" modified="2010-08-10" version="1">MNRIHSDCLEVGHLLLFWSMVFVAFRRFTAVLSSILHPWLCHRGGNRNRRSGKSSSDWAQEEELDTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV32</accession>
    <name>D6SV32_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32788">
        <property type="protein sequence ID" value="EFI32788"/>
        <property type="gene ID" value="Dthio_PD0085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="43" mass="4670" checksum="ABCDFD888A643283" modified="2010-08-10" version="1">MNEKNSGGVKKKSGISAEYWSLTTEHSGNCLKGGVCGVYVYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV45</accession>
    <name>D6SV45_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32801">
        <property type="protein sequence ID" value="EFI32801"/>
        <property type="gene ID" value="Dthio_PD0099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="55" mass="6089" checksum="BB2D45E945A4577E" modified="2010-08-10" version="1">MGVKISSRPRKMTAGAVEKSSHAERGNDKGGEFTKTRRQRSEVSKNKKRGLCPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJV7</accession>
    <name>D6SJV7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869282.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3616"/>
    <dbReference type="EnsemblBacteria" id="EFI36160">
        <property type="protein sequence ID" value="EFI36160"/>
        <property type="gene ID" value="Dthio_PD3616"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1802284at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="362" mass="40258" checksum="7801A84E1288E179" modified="2010-08-10" version="1">MFKKAERKQSKLRLGLIGPSGSGKTYSSLLIAQGLGGRIALLDTERGSGSLYADLCEYDVAELTPPFSPERYTQAIKEAERTGYEVLIIDSLSHAWSGEGGILEFVDRASQAQKNNFAAWREASPKHNALVDSILGANLHVIITMRSKTAWDVVKDERTGKTRPVKIGLAPVQRDGLEYEFTCVLELSVDGHIATASKDRTGLFDGQYFLPSKDTGQILKEWLQGGRPDNGNKENKPAEPKIDSEVEAEPVADPAPASRKKSQDVFTKKKQRQEDRPPQPLTPEDNGVTVASLVNTMRELGLSDKLDLYEAYLLGKYGNDLRKLTKDQVNEQYHNLCRCKRDQELFQRFVTFLDGLKAKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJW8</accession>
    <name>D6SJW8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869293.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3627"/>
    <dbReference type="EnsemblBacteria" id="EFI36171">
        <property type="protein sequence ID" value="EFI36171"/>
        <property type="gene ID" value="Dthio_PD3627"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1501297at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="167" mass="18736" checksum="BA1BFF66620E8DA9" modified="2010-08-10" version="1">MNTQEALQVLKPEEATLEALKQAYRAAARKYHPDINPYGEELMKLVNAAYDLLVSSLGEWAIHENAAEGPGEMSLDEEMSGILSKIGHLPGLLFEICGTWLWVTGNTYLHRQALKDAGLFFAPKKKAWFWRPPESKTSSRGQWDLDKIRTVHGSRTIKTQSLQGLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJX7</accession>
    <name>D6SJX7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3636"/>
    <dbReference type="EnsemblBacteria" id="EFI36180">
        <property type="protein sequence ID" value="EFI36180"/>
        <property type="gene ID" value="Dthio_PD3636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="53" mass="6025" checksum="B5369DD17FDBF1CA" modified="2010-08-10" version="1">MHVKQGLTGQDMEFVMDTLVPKMRHYEVHGKWSTYDSGVAKGLELAIITCFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK10</accession>
    <name>D6SK10_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lysine 2,3-aminomutase YodO family protein</fullName>
            <ecNumber evidence="12">5.4.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD3670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="12"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869335.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3670"/>
    <dbReference type="EnsemblBacteria" id="EFI36213">
        <property type="protein sequence ID" value="EFI36213"/>
        <property type="gene ID" value="Dthio_PD3670"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="557227at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025895">
        <property type="entry name" value="LAM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12544">
        <property type="entry name" value="LAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="97"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI36213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="357" mass="41360" checksum="E8E0B9776C4D4F88" modified="2010-08-10" version="1">MQEWIKELQQMVNTREKLADYVDITPDEDAAITTMRTRWGTTPYFASLMDPQDPACPIRRQVVPSLKEKENKYGIQDYLIHKENRAVGEKRPDCIARQYQDRIAFTVTDVCANYCRHCFRKELVVDQGLSLRFDVDEGLGWIREHPEVRDVLITGGDPFILSDEKLGRIITELRRIPHVQMIRFGTRTPIVLPSRINKELCEILGDFHRVPVWINTQCNHAREITEETARGVYDLMRCGVNVGNQAVLLKGINDDPQSFRELHQKLLTVRIRPYYVFYCEPAPGIDHFRTPVEKGAELIRDAIRGHTTGLCQPMYVIATNIGKVPLMPDYYLKEKTDEEYVLRNYLDQNTSLPVIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK13</accession>
    <name>D6SK13_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869338.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36216">
        <property type="protein sequence ID" value="EFI36216"/>
        <property type="gene ID" value="Dthio_PD3673"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZVE9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1908966at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="12055" checksum="F0475CBA94FFE897" modified="2010-08-10" version="1">MKFAVRIYGEVEGFTPEKLEELQKTDLYPFEVRDGRVEVEHEGEPMDIEPAVEAIATALGEKGSGYVDYIDNDEWVVWRYQLSPGHWQCTEVNPDHALEGYGHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK51</accession>
    <name>D6SK51_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase orf1 for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0029</name>
        <name evidence="2" type="ORF">Dthio_PD1753</name>
        <name evidence="3" type="ORF">Dthio_PD2682</name>
        <name evidence="4" type="ORF">Dthio_PD2998</name>
        <name evidence="5" type="ORF">Dthio_PD3714</name>
        <name evidence="6" type="ORF">Dthio_PD3835</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868404.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0029"/>
    <dbReference type="EnsemblBacteria" id="EFI32742">
        <property type="protein sequence ID" value="EFI32742"/>
        <property type="gene ID" value="Dthio_PD0029"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34398">
        <property type="protein sequence ID" value="EFI34398"/>
        <property type="gene ID" value="Dthio_PD1753"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35271">
        <property type="protein sequence ID" value="EFI35271"/>
        <property type="gene ID" value="Dthio_PD2682"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35572">
        <property type="protein sequence ID" value="EFI35572"/>
        <property type="gene ID" value="Dthio_PD2998"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36254">
        <property type="protein sequence ID" value="EFI36254"/>
        <property type="gene ID" value="Dthio_PD3714"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36365">
        <property type="protein sequence ID" value="EFI36365"/>
        <property type="gene ID" value="Dthio_PD3835"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2088406at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="113" mass="13265" checksum="8B8441125AE0BD32" modified="2010-08-10" version="1">MQTKSQKYTPEERAGFWSAHINKWRQGSLTKAEYCRRAELSKHAFYYWCKKLGHTNSRKTQEENAIVPVPLKVVQEKTHTPLRLMVNSYQVDIPGDFQQEVLAKLVRTLEEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK63</accession>
    <name>D6SK63_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">Dthio_PD3729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869385.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3729"/>
    <dbReference type="EnsemblBacteria" id="EFI36266">
        <property type="protein sequence ID" value="EFI36266"/>
        <property type="gene ID" value="Dthio_PD3729"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="28529" checksum="C678A3BAF00F7E13" modified="2010-08-10" version="1">MYTLVLLRHGESEWNLQNRFTGWTDVDLTPQGVEQAAKAGELLQEEGLSFDLAHTSVLKRAIRTLWLVLDRMDLMWIPVQRCWRLNERHYGALQGLDKSETAARYGDDQVLKWRRSYDLPPPALDYDDQRHPRFDPRYQGLDPRLLPDAECLRDTVNRFLPYWNDYLAPQILAGKRLIVAAHGNSLRALVKYLDHISDEEILKLNIPTGVPLVYRLKEDLTPIESKYLGDPEEIQAAIAATAGQGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK75</accession>
    <name>D6SK75_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TraB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869397.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36278">
        <property type="protein sequence ID" value="EFI36278"/>
        <property type="gene ID" value="Dthio_PD3741"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="639131at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005230">
        <property type="entry name" value="TraB_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PTHR21530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00261">
        <property type="entry name" value="traB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="392" mass="43260" checksum="5A131767D20CCC3D" modified="2010-08-10" version="1">MSQQNPGNLENLQQIQAGEKTVYLLGTAHVSQQSVDDVQQAVEQIRPDTICVELCPSRYQTLVHPDVWKNTDIYQVIKENKALFLLAQLGLSAFYRKIGQKLGVKPGAEMLEGVRQAERTGADLVLADRDVNITLKRVWGSLSMWGKFKLLMQLLAGMVFPGDIKKEDIEKLKKKDQLQVVMDEFSRSFPQIQKSLIDERDQYLAHKIAESPGKTILVIVGAGHIPGITTYLDQDIDIGPLTEMPGKAVWPTIIKWGIPLVIIGLLVLGFVTQGAQHSVQSIYIWILVNGLCSALAVSLALAHPYTIMAAFVAAPLTSLNPTMAAGWIAGLVQAWVKKPLVSDLEHLPKAFTSIKAFWMNPVCRILLVVVLANQGSVLGTFVAGTWIFTRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKC1</accession>
    <name>D6SKC1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoVT/AbrB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869443.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3790"/>
    <dbReference type="EnsemblBacteria" id="EFI36324">
        <property type="protein sequence ID" value="EFI36324"/>
        <property type="gene ID" value="Dthio_PD3790"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9706" checksum="A63F72E7AC4933EF" modified="2010-08-10" version="1">MDTAKLFFNGRSQAVRLPKAYRFEGKEVYIKKVSQGILIIPKDKTVWGAWEENLKKYDEPFMTDRNQFDSQQERDGLNDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKC4</accession>
    <name>D6SKC4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869446.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3793"/>
    <dbReference type="EnsemblBacteria" id="EFI36327">
        <property type="protein sequence ID" value="EFI36327"/>
        <property type="gene ID" value="Dthio_PD3793"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097351">
        <property type="term" value="F:toxin sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031848">
        <property type="entry name" value="PrlF_antitoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15937">
        <property type="entry name" value="PrlF_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="104" mass="11374" checksum="10B9F32F42A83D3F" modified="2010-08-10" version="1">MTTIREMATMSSKGQVTLPKAIRKALNIDAGSRLAFTLRGNEIVISPEDEHNDPAVASFLNLLEQDIAHGRHVSVLPDDLVKSLVTALEYDQGHDQEISGDVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKH8</accession>
    <name>D6SKH8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869497.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3853"/>
    <dbReference type="EnsemblBacteria" id="EFI36381">
        <property type="protein sequence ID" value="EFI36381"/>
        <property type="gene ID" value="Dthio_PD3853"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="316"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="463" mass="54018" checksum="3634B3B707214644" modified="2010-08-10" version="1">MSIFIGRKKEIQFLEDEFAQDRASLVILYGRRRIGKTTLIKQFIQEKNAFYFVATEESERENRRNFQHAVSDFTHNTLLKKDVLLEWDEIFSVLNEHQPEKKKIIAIDEFQYLGKARTSFPSIFQRIWDQMLAGSRSMVILCGSLVGMMVEQALSYSSPLYGRRTGQIRLDQISYQDYGLFFKHPERINLIEYYAVTGGVPRYIELFTPATDIFQAIERNILSRQSFLFEEPVFLLEKEFGETGTYFSLVKTIAAGNRKLGRISSALGMNQSGLTKYLKTLQELDLIVREVPITEKNPEKSKKGQYRITDNFISFWFRFVHPYRSYLEIENTEVVIKKIKDQFRSSHVSFVYEDICRQWLMQKGLVKSPHIQLIQAGRWWDKDVEIDLLGVTENREHAVFCECKYTAAPVDADVYRQLMEKAKNVFLPDGSEKHYVFFSQSGFTEAMMNLARSQENVHLASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKI0</accession>
    <name>D6SKI0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868325.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2596"/>
    <dbReference type="EnsemblBacteria" id="EFI35191">
        <property type="protein sequence ID" value="EFI35191"/>
        <property type="gene ID" value="Dthio_PD2596"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="195" mass="22719" checksum="4089AE3AED4F0626" modified="2010-08-10" version="1">MKTNHPTKGSSIRVEPIRRLEDIKAIKKLLRDSPRDLLLFTMGINNGLRIGDLLRLKVEDVQHLRPNEHFRIKEQKTGKHNVLLINKTVHKALANYTEKLCPDPEDYLFKSRKSGKAISVEHANRMVKNWCRQINLRGNYGTHTLRKTFGYIQRVHYGVGYELLCKRFNHSSPSVTMRYLGIEESEVNDILMNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKK8</accession>
    <name>D6SKK8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868353.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2628"/>
    <dbReference type="EnsemblBacteria" id="EFI35219">
        <property type="protein sequence ID" value="EFI35219"/>
        <property type="gene ID" value="Dthio_PD2628"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15155" checksum="27FE1C63D6B4A771" modified="2010-08-10" version="1">MKLILDTNAYAGFKLGYSELVEYIVRADVIFISPIVLGELIFGFRNGSRFSDNMKDLNLFLSHPAVETTTITDITSDRYSRIALQLKNQGTPIPSNDIWIAAQTMETGAELVTMDNHFDKVSGLVYRLFVRPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKQ1</accession>
    <name>D6SKQ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868395.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2673"/>
    <dbReference type="EnsemblBacteria" id="EFI35262">
        <property type="protein sequence ID" value="EFI35262"/>
        <property type="gene ID" value="Dthio_PD2673"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="238"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="338"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="612" mass="67721" checksum="CE67C5F33C718D47" modified="2010-08-10" version="1">MKLGRIFIIITAGICLLAIAALTYTTNRTMERELTSEYEEKAETLLFSMKAVRSHIGSVVRPEATDLLGEDEFMVELQSTSYAANQVFQQIPEEHRHEITFRTPSTKPMNPDNDATPVEAELIRTLDRMHRDGKDELEWRGIRNVDGEDYYIIAQGEENRADCLPCHRQPEDAPESMRERYPFDSPPRLEDRVETAEVVYIPMSSMYETIRQSNQFLFIMGGLGVLAIILGVYLLFSRLISRPLNSLQSYALAVEQGNLDSSIQGNFKGELASLKNSVQSMVVKLKDKIDESQEKSQEAETQSQKAMQAVKEAEEAKKQAEKAKVQGMQHAADSVDEIVEKLNSNLQELSRQVNHSSQSAKSQNERVGESSTAMEEMNATVLEVSRNSSNVAQKAEDSKERAVEGSEIVQKAVEAILKVQDHAGSLRTNLGKLGEEAEDISKIMNVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAEKTMNATKEVSQAISSIQDGTRTNIEAMESAVEAVQEATEMAKQSGRALEEIVQLISAAADEVRSIATATEQQSTSSEEINASLEEISRLSSSTAEAMEHSDQAISELVKQVNMLQDLVRELKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKS9</accession>
    <name>D6SKS9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868422.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2704"/>
    <dbReference type="EnsemblBacteria" id="EFI35290">
        <property type="protein sequence ID" value="EFI35290"/>
        <property type="gene ID" value="Dthio_PD2704"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50343ZT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="255" mass="28438" checksum="6A51432996AD2B31" modified="2010-08-10" version="1">MKSLKGPTSDNCLSARSRGKSSGFTLLEVVISMTIISMLVLVLYQAFSMGVRIWEDRHGRQDETLRLEAATSLLRADLTRAVPYNIFWEEGEALLFAGGPGAMFYVTSNGTGSISGAGEGLYFACLYVDVCPEKQEKCLYLSKSSRPSPDFVQEATAFRSATDFSRESFSPDSHMERKSILMLEGIIEAGFFYTGEQYFPFAGVPDHGLERSVQENEISFDRHWVENVLPGQVRISLLLEGQEYIIHVPVSRVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL08</accession>
    <name>D6SL08_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="10">1.2.7.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD2784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2784"/>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0711">Selenium</keyword>
    <keyword evidence="10" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="AFOR_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="10">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="625" mass="68126" checksum="77C8E9653DA69B6B" modified="2010-08-10" version="1">MRDKWYGWCGRILYVDLNSMQVKTQELPRDLVRDYLGQSGSGARLLMDMTYPGMDPLSHQAPLIFGVGPLGGTPAPCSGRFSLTFKSPLTGIFADSNCGGHFGPEFKMAGFDHLVITGKAAHPVYLWIDNDQVRIKDARHLWGLDTWEADAGIRQELGERTAQVACIGPAGENMVLMSAVICNLGRAAARCGPGAVMGSKNLKAVAVRGDRGVDIFEPAAFTEAVQEVQASILGDPLYEQASSYGTUAITPLAQGMGFLPTRNFQESVFEASSNFSGENLKDNYVQRNKGCFNCPVSCSRYCSVQEGPYAGTKGEGPEYESISAFGSKCGNSDLEAVLHANMLCNRLGLDTISTGNVLAWAMECVDKGVFSARDLGLDGLGFGNHQAMIQAIHRIAARQDGGDILAQGAWRAARILGGQDLVVHSKGLDYPAVDVRGTKGMAMAFAVSPRGGDHLKGLCLLEVAPDVYAHILKSELGIEPGDKYWLKYETKAGLMAWQEDWHCVVDSLGLCKLEGIALKPVLPAHFHRLLSTATGWSGDVQDLRRAGERIWNLERMFNCREGLGRKDDYPPKRLMQEPVKNGPSRGERLDRDKYEALLTQYYSLRGWDLDTGVPTPATRSRLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL11</accession>
    <name>D6SL11_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Filamentation induced by cAMP protein Fic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868504.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2787"/>
    <dbReference type="EnsemblBacteria" id="EFI35372">
        <property type="protein sequence ID" value="EFI35372"/>
        <property type="gene ID" value="Dthio_PD2787"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="2">
        <location>
            <begin position="116"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="208"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038925-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="369" mass="41819" checksum="E0853AAB311AA2E9" modified="2010-08-10" version="1">MPTPVYYHEGKFPPPELDWARLIPFIGPANAAVARYDGILSAVPNANVLLTPLMTQEAVLSSRIEGTQATFGEVLEYEAEHDRSRFSPERKEDIGEILNYRRAMHAALDMLKELPLCQRVIKRAHEVLLQGMRGTGRSPGEYRKGPNWIGSPGCSIEEATFVPVSAEKLPDAMRIWEEYIHAQAPQDKLVQLALLHAEFEALHPFLDGNGRLGRIFVPLFMAQVGLISSPMFYISAYFEARRDEYYERLLAVSRDNDWTGWSMFFLQAVQAQAEDNLRKAQAILSLYDSLKHRFTQLTHSQYAIHALDWIFQRPIFQSSDFAYKSSIPPATAKRMLTKLKQNDMLVEIQRGGGQRSAVLALPSLLRVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL43</accession>
    <name>D6SL43_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dinitrogenase iron-molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868536.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2820"/>
    <dbReference type="EnsemblBacteria" id="EFI35404">
        <property type="protein sequence ID" value="EFI35404"/>
        <property type="gene ID" value="Dthio_PD2820"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1995095at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="2">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="12672" checksum="AEA2FEF9EBD4C9CE" modified="2010-08-10" version="1">MIIAVSSQGQELKSPLDPRFGRAAHFILYDTENDSFAILNNEPSLNAAQGAGIQAAQAVSRGKAEAVITGHCGPKAFSALQAGGIAVYLCKENTVEEAIQAYKKGRLEQAEEADRSGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLE1</accession>
    <name>D6SLE1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2926"/>
    <dbReference type="EnsemblBacteria" id="EFI35502">
        <property type="protein sequence ID" value="EFI35502"/>
        <property type="gene ID" value="Dthio_PD2926"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="460"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="525"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="767"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="883" mass="98466" checksum="3B8DE97D495592D0" modified="2010-08-10" version="1">MPKQALPVLTRILLALLAILITPSPGFSQKEAAGDFSVFYLNSYHDGYAWSDDIREGIRHRFQESGHRVEIQMEYMDTKVFHRPGVTKRLLELYREKYSNEEYDIVIVSDDDALDFMLDYGDELFPGLPIVFCGINYLEEELLDRERTTGIVENFNVKRTLELALSIHQDKNRMVVIGDESTTGIAIKGQIKEAIPDFQGRLDFEFWTQYSLDEIADKVKDLPQDTLVYFIPFFYSAGGQVFSAGEVLENVAGFSDLPIYSNWEFLLGHGMVGGNLISGFEHGSIAAGMALDILEGKSPADIPIIHDIVDQNMFDYNVLQKQGIKQTQLPPESVLINEPPAFYELDKQVFWVIMSSLGALVIILAFLVRSIIHKRIVESRIRNQLAFQESLMDTIPQLVCWKDLNQRYMGANQAFTDFFGIESPDKIMHQTDSLLMPSRDFAQWAARMDKQVLQTGQALRKVRMSVRDQDGDSSWLEVNKIPLRDEKGEIVGTLSTAENITNEINLERQLLQSQKMEAMGTLAGGISHDFNNILTSIMNSTELAQGDLDPDSPAYQDLERVLKASHRGRDLVQRILTFSRPSQEGFRPTVLPELVRDSVSLLQSSLPRNIEVRSSVSGGYEPVNVNPTQISQVVMNLCTNAFQAIQDQKGTLTINLEEIELDVYRAEELDMPAGKAFRLEISDTGPGIDRRDLDKIFDPFFTTKSQSGGTGLGLAVVLGIVKNHKGVIQVDSSPDQGTSFEILLPAREPGNQESSPSGASLKRGSGTLLFVEDDQDLLETTPRSLQAMGYSVFSASSAQKALEILGQDIPLDLVITDFDMPGLNGIELAKKIQAEHPDLPVMLITGRIQALEGIEQPDNIRLTLSKPFNQADLSQAVSTAITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLP3</accession>
    <name>D6SLP3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868733.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3033"/>
    <dbReference type="EnsemblBacteria" id="EFI35604">
        <property type="protein sequence ID" value="EFI35604"/>
        <property type="gene ID" value="Dthio_PD3033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="152" mass="17086" checksum="74C5DBF926F95C2D" modified="2010-08-10" version="1">MRKVCLLVLLHILVLGGIWLWRSDPNPAVHPGDPAWIGMTGQDMQKSFRGELMLPGQPPADVEIDGHARVSLWIYLPESMLENLRRDSPVSIRLQGGEEDVLTGRVSGVDSDSRKRGSDTYYRVLLELDAEPGQIKDMKIIEPYIHNEQGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLR1</accession>
    <name>D6SLR1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenase maturation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HypD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868751.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3051"/>
    <dbReference type="EnsemblBacteria" id="EFI35622">
        <property type="protein sequence ID" value="EFI35622"/>
        <property type="gene ID" value="Dthio_PD3051"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="666873at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="360" mass="39178" checksum="E5ED0A1E79950A3A" modified="2010-08-10" version="1">MNLSSEFRDPDLCRRVLEQIQHLADSPFRFMEVCGTHTVSIFQSGIKSLLPENISHLSGPGCPVCVTHDLEVNTFLALAKMDLRLATFGDLMRVPGSRGDSLKKVQAEGARVDIVYSAFDALQLAVDNPSENVVFLAVGFETTAPTVAATVKVALKQQVENFFILPMHKLVPPALQALASDPDIRVDGLLLPGHVSTITGIEPFMFLAGDYNLPAVISGFEPLDILQSIQILLRMHKEKTPAVINSYKRAVADQGNPRARKVMQEVFKPVDTAWRGLGDIPGSGLSLRKEYLGFDARRKFEPAPLQPETNTGCKCGQVLKGKILPPQCPLFASVCTPAEPVGPCMVSTEGSCAAFFKYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLU3</accession>
    <name>D6SLU3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868783.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3083"/>
    <dbReference type="EnsemblBacteria" id="EFI35654">
        <property type="protein sequence ID" value="EFI35654"/>
        <property type="gene ID" value="Dthio_PD3083"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="187" mass="20699" checksum="F334E51F3E972030" modified="2010-08-10" version="1">MRIISGTLKGRVLKTGSGPGYRPATGKVREAIFSMLQGQIEDWSRVQVLDLFAGSGAVGLEALSRGACTAVFVENDARAVKILQENLQRLQIPVNRAKLIKKDAESFLARKAEHGFELVFVDPPYGRNLLNQVLPGIISQGWLLPRGVLCAEVESRLQVTPETYPGLDLIKDKHYGQTRILMWQKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM15</accession>
    <name>D6SM15_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorismate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnA</name>
        <name evidence="4" type="ORF">Dthio_PD3155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:40051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="4.2.1.151"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.151" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868855.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3155"/>
    <dbReference type="EnsemblBacteria" id="EFI35726">
        <property type="protein sequence ID" value="EFI35726"/>
        <property type="gene ID" value="Dthio_PD3155"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1062841at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00995">
        <property type="entry name" value="MqnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030868">
        <property type="entry name" value="MqnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37690">
        <property type="entry name" value="PTHR37690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="280" mass="32072" checksum="BD8FFED2B181AE04" modified="2010-08-10" version="1">MNNSQLKVGRIDYLNIWPLFHSINNSLCTDVSFVSGHPAMLNQALARKDIHVSPSSSIEYLYRAEDYLLLPDLGISAASQVQSVIFCLPFPFDQLERYAGQNGEIFLTRASDTSRALLKILWHYHWKLPSPRWRMLDPGQGLSTGKPFLEIGDHALSIFLNAHQNMHVLDLAGEWNKMTGLPFVFALWILRRDLQGRQRSVLARLARELLQARRAMPGRYHELSMLYPGTEFTPEQITDYWQKMDYGLEQEHKAALAAFGRYLSDMDEIPGMPALDFFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM61</accession>
    <name>D6SM61_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35772">
        <property type="protein sequence ID" value="EFI35772"/>
        <property type="gene ID" value="Dthio_PD3204"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039060">
        <property type="entry name" value="Antitox_HigA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40455">
        <property type="entry name" value="PTHR40455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="139" mass="15779" checksum="4560E30EAFE16139" modified="2010-08-10" version="1">MVLGLIKNDTEYYQALERIETLTSAGMDHEEERELELLVHLVDKYEREQYPIEYPDPVSAIRLRMQDLGLRQKDLAEIIGSSSKVSEVLNKKRRLSLAMIRALHAHLNIPAEVLLQEDGVRCQGKEQSAGGGTPVFVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SML3</accession>
    <name>D6SML3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869052.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3365"/>
    <dbReference type="EnsemblBacteria" id="EFI35924">
        <property type="protein sequence ID" value="EFI35924"/>
        <property type="gene ID" value="Dthio_PD3365"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04282">
        <property type="entry name" value="glyco_like_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="29105" checksum="90B0243633D54677" modified="2010-08-10" version="1">MHSSRACLALMLKYPSPGRVKTRLGKDIGQVNAALLYRSFVQTTLATCRTLSWPILLFCHPDSTLDKYRAWLGEENDYFIQGPGNIGDKMRAAFEQSFELGFDRVVLAGTDVPQMFRETLQQAQKGLESCKAVLGPALDGGYYLLGLHRDVFFPGVFSDVPWSTSRVLETTLNRLKDLGLNPHILPELRDVDTLEDFRALFRSQQGVEPNSYLSWDQAVQAYLACMDCSQADSREFEAVEDRKKVVLQGSRKHAKHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SML5</accession>
    <name>D6SML5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3368"/>
    <dbReference type="EnsemblBacteria" id="EFI35926">
        <property type="protein sequence ID" value="EFI35926"/>
        <property type="gene ID" value="Dthio_PD3368"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="854580at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9412" checksum="B98B1FB885AA4E11" modified="2010-08-10" version="1">MYRKRKIFASLEEQTKNRKITLLIGARQVGKTTLLREVYNRLPQDCPKLFLDLDEYSNYEKVSTYENCLNVLTRALPATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMP4</accession>
    <name>D6SMP4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Flagellar biosynthetic protein FliR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD3397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869083.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3397"/>
    <dbReference type="EnsemblBacteria" id="EFI35955">
        <property type="protein sequence ID" value="EFI35955"/>
        <property type="gene ID" value="Dthio_PD3397"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942709at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006303">
        <property type="entry name" value="FliR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01400">
        <property type="entry name" value="fliR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="262" mass="28857" checksum="270995983BAFCC9F" modified="2010-08-10" version="1">MDIFNFNPETVFSFWLTFFRVSLVVFLLPFFGGEAMPVPIKAALCIVLSLALWPHLSFDAQYFPEHPAQIAVMIMGELVLGLILGLIVHFLFAAIQTGGDLIAFQMGFKMMNVVDPLTGLQESITTQFLYMCSMLVFLSINGHLYMLMGLTQSFDLIPPGGLFITPELINQIIYYSSQIFVLAFKIASPIIATVFLVNLGLAFMARTAPQMNVLLLGFPIKIAVGLLFLSLVFQLISLYVSGFISDLGGTMYNLLRAAAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMX8</accession>
    <name>D6SMX8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3482"/>
    <dbReference type="EnsemblBacteria" id="EFI36039">
        <property type="protein sequence ID" value="EFI36039"/>
        <property type="gene ID" value="Dthio_PD3482"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="115" mass="13177" checksum="D2692CE833211886" modified="2010-08-10" version="1">MANPQELADMFKVLATPARVRILQILKNDCLCVNALARELKITPASVSQHLRVLRDSGLVRGRKHGYYVHYEVDLENLHRWKTSAQLFLTAPLDRMPELKSKTSNQKNKEVNHGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMY0</accession>
    <name>D6SMY0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3484"/>
    <dbReference type="EnsemblBacteria" id="EFI36041">
        <property type="protein sequence ID" value="EFI36041"/>
        <property type="gene ID" value="Dthio_PD3484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="44" mass="4849" checksum="FFD58189FE092F9E" modified="2010-08-10" version="1">MFRYHLMAVSKNNVSSAYGMSIPSLVICLLPEVNLKFTSAKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN16</accession>
    <name>D6SN16_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylation/Crystallin J1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3524"/>
    <dbReference type="EnsemblBacteria" id="EFI36077">
        <property type="protein sequence ID" value="EFI36077"/>
        <property type="gene ID" value="Dthio_PD3524"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="236" mass="25843" checksum="2F48E00D07025006" modified="2010-08-10" version="1">MLAPPEWLRFRGCLAGLAAGDAVGTTVEFMTRGGFEPLRDMVGGGPFNLRPGQWTDDTSMALCLAESLIEKGGFDARDQMERYCRWMETGYLSSTGSCFDIGSTVAAALQRYRKTGEPYSGSTHPRSAGNGTIMRLAPVPMKYFPDMDLAESMAGESSRTTHGAQECIDACRLLARMTVRALSGRSKEEILMADRDSVSGGGKYLTRSSTCLSPRIHPVKQTSGLRLRRPVKWKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN17</accession>
    <name>D6SN17_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3525"/>
    <dbReference type="EnsemblBacteria" id="EFI36078">
        <property type="protein sequence ID" value="EFI36078"/>
        <property type="gene ID" value="Dthio_PD3525"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20073at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="465"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="713" mass="82986" checksum="8E148D6332F64B1B" modified="2010-08-10" version="1">MYNGICRTERLKVPGAIDLVDSKDNNHLQVHEDDILAYADMDRVLEELELRGTMPVEYIKSAPLIMSFMQNYKVKHDIQEEMKAKPEKLPLLNSPRLWINKNKVAGYKPLNIHHARFEKLKETVLSGEAARLLWVPPSLPYYELGGPFRNQENFSKTLVFSAWEMVPRAVSTLISYEAERLTVGTLIKKTPGQQSERRSYFPDSKNKRFPPPRVTFSVKDKEPANMNALCLLHPSVTLASMYDPIQAMNRDMSIKDILREVQGKIEGHLDGFRHYVRREGQRQDERWYYMAPLLMGRSQPRIQEWFKNPVLQSVDEDYDGVVVQEEDSHALSLHLERLKSLYQDPEQVELGLMPEDLARVLTNMAIASPAICALRMLGPDTPGAVGLSWQLAKTIVERFNTQEAIAMVDLSYGKAGEGVHWKNILRYCLDGNLQAVLDEYAHMLLDGHDKQHCSPEEVEKRNQTLIRDMIRTLKTHTASYNVDTYPAFRHRVKNYDRIDLKKKQIRMRSSYAVGFYDMKDEGKSGQRKENIRLSLNSPFRPFVLTTTSIGQEGLDFHCYCRKIFHWNLPGNPIDLEQREGRINRYKCHAIRQNIAFKYGKNRFYRDVWQEMFDHALLQEKSSKTSDLVPFWRLTGQDTYNPACNIERIVPLYPLSRDSARYERLIKILSLYRLSLGQTRQEELIEYLFENGVSQEEVEQLFMNLSPYFKEVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN68</accession>
    <name>D6SN68_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869524.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1543"/>
    <dbReference type="EnsemblBacteria" id="EFI34194">
        <property type="protein sequence ID" value="EFI34194"/>
        <property type="gene ID" value="Dthio_PD1543"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="304" mass="35906" checksum="E2A5A710EDE509E6" modified="2010-08-10" version="1">MPRNARFTLPDRPAIYHIISRTALSGFPLGDIEKDKLLDIIRYFSRIYFVDILGFAIMGNHWHLAVKVYPHEYAYRDEVKERFARRYGEDVHFGDQDMEKFSKKWTDLSEFVREIKQTFSRYYNKRHNRRGFFWGERFKSMIVQEGHTLVNMLAYIDLNPIRAGIVKKPEDYRWCSLGYHTQTGNKDGLLSIDFGMKEWNEFDPKEIVRKYRQFVYETGAVDAGKGKVMDKKIVEKARKKGFKISRSDRFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDTRKFTPVGGVEGTYSMKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN95</accession>
    <name>D6SN95_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1572"/>
    <dbReference type="EnsemblBacteria" id="EFI34221">
        <property type="protein sequence ID" value="EFI34221"/>
        <property type="gene ID" value="Dthio_PD1572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031042">
        <property type="entry name" value="Glyco_TIGR04440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04440">
        <property type="entry name" value="glyco_TIGR04440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="354" mass="41134" checksum="A024708EBC975EDD" modified="2010-08-10" version="1">MPILFIPTKNRPASLSWVLNYLARFYPDTRVVIADGSDECYKASNMSSVEKMQSGLSVNYKTYSQETGFIDRCLDALNSEPEEYIVFGADDDYPNMELMFKGEKFLKKNPDFSTAMGARVVLNLKKDEVIRSRLAVVRPVECAEAWQRMKIYSKWSFATTYAVTRRRHLLKRFKRLKQLAPIGFYDFMVGLHDAACGKIKAYPEVGFFTTRTYTHNFIRNTDKLFFIHNSKDILKLQEIVREDLEFEGLLTTEETEKQSEIIMLNRIAELTGRDFRKLANFSKSKLFNDHIVQSQYKLYNNIFDLSTKEGKKYSKHLRYIYQAMQSIVESSNRLEGKFVNTLDGKPDQEKQGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNJ1</accession>
    <name>D6SNJ1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, ModE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869645.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1668"/>
    <dbReference type="EnsemblBacteria" id="EFI34317">
        <property type="protein sequence ID" value="EFI34317"/>
        <property type="gene ID" value="Dthio_PD1668"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028755at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="13523" checksum="6B656F2276AE8B7F" modified="2010-08-10" version="1">MKSKYDVGLSVWLHTGSETIFCQGRALLLEGIEEHGSLRQAAKSLGMSYRAAWGKLKKTQDILGIDLVVLSGEQPRRYELTSRAREILNAFNSWRNRMKTIAGKEARELQELFKGAGPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNK6</accession>
    <name>D6SNK6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP dicarboxylate transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869660.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1683"/>
    <dbReference type="EnsemblBacteria" id="EFI34332">
        <property type="protein sequence ID" value="EFI34332"/>
        <property type="gene ID" value="Dthio_PD1683"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="903568at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="419" mass="44885" checksum="E975749A7CC418E7" modified="2010-08-10" version="1">MALILFTSFLVLLFLGVPVAIAIALASMVILMQEGVPLMLVAQRMFSGTDNFSLIAVPLFILAGDIMARGRISERLVEFADALLGFLRGGLSIVAVMAGMFFAAISGSGAASTAAIGSSLVPELKRKGYCETSSASLIAASGTIGVVIPPSVPMILYAVMAQESVSRLFLNGFIPGVIMGLVLIVIAIRQAYQRDYPPGSPFSVANIARTFYRAIWGLLTPFIILGGIFSGFFTPSEAAVIAVNYSLIASLFIYRDMGLKDIYRIMRRSIITTGVIMFIIATSSVMSWVLANWNIPAMIAQSVLEISTNPYVLLLLITLLILATGIFVETASALIILTPVLLPLVKLLDICLVHFGLIMVMGLAIGMITPPVAINLYVASSITGLPIERISRSVIPFLLGLLLVLFIVVYLPLFVPVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNS7</accession>
    <name>D6SNS7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YcfA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869726.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1759"/>
    <dbReference type="EnsemblBacteria" id="EFI34403">
        <property type="protein sequence ID" value="EFI34403"/>
        <property type="gene ID" value="Dthio_PD1759"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="63" mass="7242" checksum="6AE75B8D7AE83200" modified="2010-08-10" version="1">MKFIELVRLLEQKGFKIIIEKGSIRYYGKPGWDKLIRIDYHGSKEVPTGTCHQILKAAGIKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNU1</accession>
    <name>D6SNU1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type III restriction protein res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869739.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1775"/>
    <dbReference type="EnsemblBacteria" id="EFI34417">
        <property type="protein sequence ID" value="EFI34417"/>
        <property type="gene ID" value="Dthio_PD1775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377818at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="462"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="647"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="805" mass="89734" checksum="D8E0D1DED4A79139" modified="2010-08-10" version="1">MSSMDDIDKASLLQALKSAEAECLRLRAENERLRARLGLATETLEEDKSKTPSLSTSLQEPHLLSSASVFCKSSPEEKIALFRQLFRGREDVYPVRWENKQGRSGYTPACANEWKRPLCGKPKVKCGQCESRLLKPVTDQVVFDHLAGNQTIGVYPLLPDDTCWFLAADFDKKSWQEDAAVFLEICREMEIPASLERSRSGNGGHVWIFFNSPVSAHNARKLGCAVLTRAMERRRELGFDSYDRFFPNQDTLPKGGFGNLIALPLQYYPRARGHSVFIDSSLQPYPDQWAFLSGVNTMSPADVEALVHEAGQRGAVAGVPDSVEEDTRRPWTLPPSGKKPPEGVSGPLPREASLIQGNQIYVVKGGLPAEVLNRLTRMATFQNPEFYRAQAMRLSTFGKPRIINCTEEFPDHLALPRGCLEEALVFLKSLGVQVNISDHRNTGQAIDIGFNGALTPEQHRAAQAMAEHDNGVLSAATAFGKTVVAAWLIAERKVNTLILVHRKQLMDQWQERLGTFLDLPANSIGRFGGGKNRVSGVVDIATLQSLNRKGEVLDLAADYGHIIVDECHHVSAFSFEQVLRKAKARYVCGLTATPIRKDGHHPIIFMQFEHVVVPRRTDFALPANMDNPGIQEVYSALAGDEARNEMILNDLFNALEDGCSPILLARLVSHVEELEKRLQNFVRNVIVLRGGMGKKQRQAVFERLAAVPDTEERVLIATGSYIGEGFDDARLDTLFLLSPVSWRGTLQQYAGRLHRMHSNKRRALIYDYVDEHVPQLARMFQKRLAGYRAMGYKTAEESPGEHVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNV7</accession>
    <name>D6SNV7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869755.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1792"/>
    <dbReference type="EnsemblBacteria" id="EFI34433">
        <property type="protein sequence ID" value="EFI34433"/>
        <property type="gene ID" value="Dthio_PD1792"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="277" mass="30659" checksum="49A4685006D351E5" modified="2010-08-10" version="1">MQLTVLADNNTFISRYFLAEPALSLFIQVQGRTILLDCGFSDVFLRNAGTAGLDLLQLDTIAFSHGHLDHTWGMTELVRMYARAALEGRPHNRPQVLAHPRTFESVMDERGVDQGSMLSKDKVEQHFPLKLSTTPVYITPGLVWLGEIPRTTSFESRKALGWKTDDSRPDYVPDDTALAYISPEGLVIVTGCSHSGICNIVHHARQVTGEDRVVDIIGGLHLQSPDEEQLTGTIDFLKTLNLTDLHACHCTDLYSRTSLAADLPLRATGCGMQLNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP49</accession>
    <name>D6SP49_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD1894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869845.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1894"/>
    <dbReference type="EnsemblBacteria" id="EFI34525">
        <property type="protein sequence ID" value="EFI34525"/>
        <property type="gene ID" value="Dthio_PD1894"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="791672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="175"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="786" mass="88544" checksum="3ABB670EB456904E" modified="2010-08-10" version="1">MENGQLNWIANFIWNIADDVLRDVYVRGKYRDVILPMTVIRRLDACLEPTKQDVLKMSEQLDKAGVANKVGALSRAAGADANHAFYNDSPFTLRDLQSRGKAQQLKADFETYLDGFSPNVQEILEKFKFRNQIPTLVDADALGPLIEKFLNPDINLCPHPVRDVEGNVRLPGLDNHAMGTIFEELIRRFNEENNEEAGEHFTPRDVVKLMANLIFWPIADDIRSATYRVYDGACGTGGMLTVAEDTLQGLASSRGKNVSIHLFGQEVNPETYAISKADLLLKGEGQGAENMKFGSTLSRDAFPSGEFDFMLSNPPYGKSWKMDLDRMGGKKDMSDHRFVVQHDGDELSLITRSSDGQLLFLVNKLTKMVEPTERSPLGSRIAEVHNGSSLFTGDAGSGESNIRRWIIENDWLEAIIALPLNMFYNTGIATYIWVLTNAKPEERKGKVQLIDATDIYQPLRKNMGAKNCELSEEQIKQICEMFLAFEETEQSKIFPNAAFGYWKIRVERPLRLHSQLTRKAIQGLRYASGDEDIRQALHEEFGDTIFENFSSVRKQVEQTLHDWGGNGDEDSDGDEDSDTPKRTVIPEKKRKKLLKADTWKRDKKLYDAARALRDELGEDVFTNHNIFRDAVADGLKKLGIKLSAGEQKIIFNAMSWRVEDAPPVIKKAHKPGKAEVDPLHGLYANPEGDPGLVLEYEPDSELRDSEQVPLLEEGGIEAFFRREVLPHVPGAWIDESATKIGYEISFTRHFYKPPELRPLEEIKVDLLALQEEGEGLLEEIVGGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP52</accession>
    <name>D6SP52_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869848.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1897"/>
    <dbReference type="EnsemblBacteria" id="EFI34528">
        <property type="protein sequence ID" value="EFI34528"/>
        <property type="gene ID" value="Dthio_PD1897"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="466535at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="181"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="345" mass="39975" checksum="2E544DA46783081F" modified="2010-08-10" version="1">MAEQNSPFTPHTSNFYPDLLAEIKERVRAAQYEALKAVNTELVGLYWDIGRMIVERQADAKHGSAIADQLSKDLRAEFPGIGGFSRRNIFYMREFYLLYRDDERVQPLVAQIGWTHNLAILQRCKDPLKREFYLRMTRKFGWSKNVLIHQIENQSYEKSLLGQTNFDQALTPELRAQAKLAVKDEYTFDFLELGEEHSERELERALIGRIEGFLRAMGGMFAFMGSQYRLNVDGEEYLIDLLLFHRRLRCLVAIDLKIGKFKPEYVGKMQFYLTALDKQVRQEDENPAIGIILCKEKNRTVVEYALHDARKPIGVATYEITRTLPQSLEGELPSPEDIAQLLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPE3</accession>
    <name>D6SPE3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rv0623 family protein transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869939.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1991"/>
    <dbReference type="EnsemblBacteria" id="EFI34619">
        <property type="protein sequence ID" value="EFI34619"/>
        <property type="gene ID" value="Dthio_PD1991"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011660">
        <property type="entry name" value="VapB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07704">
        <property type="entry name" value="PSK_trans_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="83" mass="9246" checksum="CD686AE7A50D2F8D" modified="2010-08-10" version="1">MALSIRNPEAERLAREVAARSGENITQAIIHSLEERLQRLGHQQQAAARLEELQAIAGRCQALPDLDQRSEEEILGYDEHGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPG2</accession>
    <name>D6SPG2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ileS</name>
        <name evidence="15" type="ORF">Dthio_PD2010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869958.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2010"/>
    <dbReference type="EnsemblBacteria" id="EFI34638">
        <property type="protein sequence ID" value="EFI34638"/>
        <property type="gene ID" value="Dthio_PD2010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="29"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="14">
        <location>
            <begin position="690"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="zf-FPG_IleRS" evidence="13">
        <location>
            <begin position="904"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="607"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="907"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="910"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="927"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="930"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI34638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="937" mass="107224" checksum="F0C90C09BB28FB61" modified="2010-08-10" version="1">MTNYKKTLNLPQTTFPMRANLTQNEPGTLKFWEETDAYKQMIQAGGEAPRYVLHDGPPYANGNIHMGTAMNKILKDIIVKSKNFNGYLAEYVPGWDCHGLPIEHKVDQQLRAKGKEVPPLTVRRLCREYATKYLGIQRKEFKRLGVLGVWDDPYQTMHPQYEAATARELGRFIQNGQVIRGKKPIYWCIDCRTALAEAEVEYDQHTSPSIYVAFPVKDTGLQKIFPQVDPDKTYALIWTTTPWTLPGNKAIAAHPDLEYSLVQVDGAFYILAGELVETAAGIFGWQDYTDMGRVRGSELEGLQARHPFLERSSPFVLAGYVSLESGTGLVHTAPGHGREDYETGLKYGLEVLSPLDDHGRFDDSVPFLAGKNVHEANPLVVSRLEEQGLLPAQKKMTHSYPHCWRCKQPVIFRATTQWFITMEANSLRHKALEAIKEQVQWIPAWGRERIYSMIEHRPDWCISRQRNWGVPIVALICGKCDHAYTDPEWFFSIVERFEKHERGCDYWFEAELEEVVPQGLSCPECGSQEWQKEDDILDVWFDSGTSFAAVLEKRPECSFPADMYLEGTDQHRGWFHSSLLASMGTRGSPPYKTVLTHGYVVDGEGRKMSKSIGNVIAPQEIIDKYGAEILRIWVSAVDYQEDVRISQEILTRLVDAYRRIRNTCRYVLSNLYDFDPQKDMVDFGRMHPLDRYTLHLVMEKDQAMHRAYERFEFHKVYHNLHNLCVLELSSFYLDIIKDRLYVPAPESLERKSAQSVLYHVLQVLLKNMLPILSFTAEEIYRHLPEKLQGDSDTVFGWRPALDGVGPIEPEEKELWDMVGRVRQEVTRAIEPLRKSKELGHSLDSHVILYLEKDKLKLLGQVQEHLRDVFIVSKAGIRPLEEAGQDSIAAQEEEGLRIEVRRAPGNKCPRCWVYSEDLGPDADADAVCPRCSQVVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPG5</accession>
    <name>D6SPG5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ORF">Dthio_PD2013</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869961.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2013"/>
    <dbReference type="EnsemblBacteria" id="EFI34641">
        <property type="protein sequence ID" value="EFI34641"/>
        <property type="gene ID" value="Dthio_PD2013"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="138"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="363"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI34641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="429" mass="46097" checksum="EAA3994BB2518F52" modified="2010-08-10" version="1">MSVISDILARQILDSRGNPTIEVEVVLESGIIGRAAVPSGASTGSREALELRDGEKAYGGKGVSLAVKHVTEDIAGDLIGMDALRQVEIDEFMIDLDGSENKSKLGANAILGVSMAVARAAATYTGLPLYQYIGGINSKVLPVPQMNIINGGAHAANNLDIQEFMVMPLGASTFSDALRMGAETFHTLKKLLSRDGLSTTVGDEGGFAPNFKSNAQAFEYIIKAIEEAGYQPGSEIALAIDAAASEFYRDGKYHLTGENKILTSDEIIDYYQELAKKFPLISIEDGLAESDWEGWRKFTSMAEDTLQIVGDDIFVTNPSILAEGITTGVGNSILIKLNQIGTLTETMDTIEMAKSSAYSTVISHRSGETEDSFIADLAVAVNAGQIKTGSASRSDRLAKYNQLLRIEEELEEQAIYFGPAIALQWFGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPG7</accession>
    <name>D6SPG7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">Dthio_PD2015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869963.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2015"/>
    <dbReference type="EnsemblBacteria" id="EFI34643">
        <property type="protein sequence ID" value="EFI34643"/>
        <property type="gene ID" value="Dthio_PD2015"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="292"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="341" mass="36884" checksum="2BF4C2D0D2C765E7" modified="2010-08-10" version="1">MFISKLFSLFGKSLAMDLGTANTLMYTPRDGIVLNEPSVVALDSRDGKVLAVGREAKEFLGRTPQRIVAIRPMKDGVIADFEVTNAMISFFIKKVIHGFNLVKPKMVICVPTGITQVEKRAVIESGLQSGAREVRLVEEPMAAAIGAGMSIEEPLGNLVVDIGGGTTEVAVISLSAVAYSESVRVAGDEMNEAIQRFIQEEFQLLVGENMAENIKMNIGTAYPPPEPMTFRVQGKRIVDGNPAAVEINDAQVREAIQEPVRAIVHAVHQAMEKTPPELVSDIADNGILLAGGGALLKGLDQLISKEVQVRVQVDEEPLTTVLRGTGKALTQEKKYSYVFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPG8</accession>
    <name>D6SPG8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869964.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2016"/>
    <dbReference type="EnsemblBacteria" id="EFI34644">
        <property type="protein sequence ID" value="EFI34644"/>
        <property type="gene ID" value="Dthio_PD2016"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1345242at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="172" mass="19806" checksum="AE865432DA05BE59" modified="2010-08-10" version="1">MLSTTTSRNILEVVDGKNRPLGVFPESQVHFHGLHHRSVAVALYDRQGLIYLQKRTESEPPYCGRWDLPASGHVLAGEAVQEAASRELRERTGLRLAGFRLVSLVDGRRETNYEFVYVFNAGRIRKLRVLSLKKNRDGLLLDSRELSMLIQENPETVTPWLVYLWRLGLFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPH6</accession>
    <name>D6SPH6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869972.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2024"/>
    <dbReference type="EnsemblBacteria" id="EFI34652">
        <property type="protein sequence ID" value="EFI34652"/>
        <property type="gene ID" value="Dthio_PD2024"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001072">
        <property type="entry name" value="RNA_ligase_Pab1020"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01048">
        <property type="entry name" value="Y414FAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01209">
        <property type="entry name" value="TIGR01209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="361" mass="41787" checksum="7DCB75AA1EC56B77" modified="2010-08-10" version="1">MLDQDQGIEHNEYNGLVYSRQRKDSSFPRGTVHLYNEDQSRPGRSITGFPHIKRTYHLHAGIKRLFKNDSFKAEEKLDGYNLRVFSHAGRLLAATRGGFICPFSTEWAGIWAEEYDLDGFFRDYPGHYLCGEVLGDNPYNRQRGVDLSPGAHFFVFEVCKPDGTFLPVSTKEELLREYGLPAVKELGTFNALQGEELYALLRDLNSRGKEGVVLKSPDSSRRMKFVTPECDIQDIKDGLEVGFDLDMGFFQSRYMRVVYFVQELGLDKDEYSRKLGRAFMDGIPVSENYQGAREEYTVYLSSRNTWQSLLSMLISQIKIRTLETSWQHVRGREMLKVRFARIYTRSGKRYQRMIKGVLHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPJ3</accession>
    <name>D6SPJ3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein Dthio_PD2041</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869989.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2041"/>
    <dbReference type="EnsemblBacteria" id="EFI34669">
        <property type="protein sequence ID" value="EFI34669"/>
        <property type="gene ID" value="Dthio_PD2041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1070303at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="266" mass="28694" checksum="8F767D4949635C3A" modified="2010-08-10" version="1">MDREPVVAGQFYPGSAAALDEKLSRYLQGEQASARTLLAMVPHAGYPFSGPVAGKVLARSNLASRIILLGPNHTGQGQRIAVWGDGSWRLPGGEVMVDEDTASVIGKLPGYSFDYQAHLREHSLEVILPFLARAVPGCKIVPISVAEPDLQVLMRAGEDLARTIRDLALDVSLVVSTDMSHFVPQEQARRLDHMAIERILDLDPQGLHQVVKQNRISMCGVMPTTLGLACVREMGARSTEFIDYATSGDAIGDYSQVVGYAGVVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPK2</accession>
    <name>D6SPK2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34678">
        <property type="protein sequence ID" value="EFI34678"/>
        <property type="gene ID" value="Dthio_PD2050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="59" mass="6867" checksum="FA343AD6D1DE0A0B" modified="2010-08-10" version="1">MHKQDGKPRFILRGCSSKAFISKSVLSWMPCLKKTKCSMDDPGLKNYFVTYTFKPFFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPR9</accession>
    <name>D6SPR9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870063.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2118"/>
    <dbReference type="EnsemblBacteria" id="EFI34745">
        <property type="protein sequence ID" value="EFI34745"/>
        <property type="gene ID" value="Dthio_PD2118"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="87" mass="9872" checksum="13DBB8DAB339E1D1" modified="2010-08-10" version="1">MDLNGSLAATGMPAGLNTDPVAHDAWFRARVREALEDSRHPMLHEDVEARFETRRNKARHISPKTFHSIKKSLKLLIKPGKQFELAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPS6</accession>
    <name>D6SPS6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2128"/>
    <dbReference type="EnsemblBacteria" id="EFI34752">
        <property type="protein sequence ID" value="EFI34752"/>
        <property type="gene ID" value="Dthio_PD2128"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="111" mass="12721" checksum="A45919AD1A715411" modified="2010-08-10" version="1">MIGAIAGDIVGSVYEWDNIKTKDFDLFTSRSFFTDLAPPWDSEDLEEMVDELEPLDDAAGEDMAREFIRGLSNQLRLWLARDGVGRQYRMDFQCPSMVIFCWSKMQGKGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ55</accession>
    <name>D6SQ55_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870195.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2272"/>
    <dbReference type="EnsemblBacteria" id="EFI34881">
        <property type="protein sequence ID" value="EFI34881"/>
        <property type="gene ID" value="Dthio_PD2272"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1542506at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="109"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="237" mass="26606" checksum="F37CAA7F098A1E9B" modified="2010-08-10" version="1">MLHRYPATNIYALDISSLDPDQDRWKPWLGQERIAALSRLRKKQDRSRCAGAGLLLAYVIKKHAPGFSVPPLTVTGSNGKPYLPQLPELQFNISHSGKWVVCGAGDKPLGLDIEKVQRDITAVARRYYPQRELDWLQTLPPNRRQAALIQGWVLRESCMKATGLGLSLPLKDLEIVFNPEVQVYLTRKGVKTRCAAALCAFDDQEYRLALTVMDASHPPSYTLEHIDLETITGTETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ76</accession>
    <name>D6SQ76_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein ComEA helix-hairpin-helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870216.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2293"/>
    <dbReference type="EnsemblBacteria" id="EFI34902">
        <property type="protein sequence ID" value="EFI34902"/>
        <property type="gene ID" value="Dthio_PD2293"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088022" evidence="1">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="10121" checksum="DA0CED5E9B251E5C" modified="2010-08-10" version="1">MIKFSLKVVILFFALTLFLTPASSMAGDHININTADQQELESLQGIGPALSERIVEHRERFPFEEKEDIKQVSGIGESIYENIKDVIVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQE2</accession>
    <name>D6SQE2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">Dthio_PD2360</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870282.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2360"/>
    <dbReference type="EnsemblBacteria" id="EFI34968">
        <property type="protein sequence ID" value="EFI34968"/>
        <property type="gene ID" value="Dthio_PD2360"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="923547at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="60"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="178"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI34968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="348" mass="37696" checksum="3908F0C9DD7899D8" modified="2010-08-10" version="1">MTRRGEAYQQAGVDTEKAGRFVESIKSMVAQTHVKGVINDIGGFGGLFKLDMNELQEPVLVASTDGVGTKLKLAFLFDRHDTIGIDLVAMSVNDVLVQGAKPLFFLDYLATGKLDTRQGEEIVKGVAQGCIQAGCALLGGETAEMPDFYPPGEYDLSGFCVGVVDDSRIVDGGEIRRDDVIIGLASSGLHSNGFSLVRKLLTQSGLKGEDIFPGTSSEVREVLLQPTRIYTAEVKGLMRDIRIKGMAHITGGGFYDNIPRILHRGLGARINFGSWDIPPVMHWVREQGRMNWEDMLQIFNCGIGYVMVVSPGDSEEVCSRLAGMGCPAWEIGRITGALADGDTVVMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQN9</accession>
    <name>D6SQN9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisA</name>
        <name evidence="11" type="ORF">Dthio_PD2459</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8 10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870379.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2459"/>
    <dbReference type="EnsemblBacteria" id="EFI35065">
        <property type="protein sequence ID" value="EFI35065"/>
        <property type="gene ID" value="Dthio_PD2459"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="794219at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="244" mass="26495" checksum="47559AA71188EC8B" modified="2010-08-10" version="1">MIIFPAIDIKNGQCVRLRQGLENEVTVFSADPGAMAEHWERLGAKWLHLVDLDGAFSGKPVNRNLIADICSRIKIPVQLGGGIRDLDTAQAYIDAGVKRLIIGTMALEEKDGFRELSSSFPGRIGVSLDARDGRLKSRGWVEDTGLDVDQVIPELESMGASFFIYTDIARDGMQSGVNVAALEHVLKLTDRPVIAAGGISTLEDIQEIHHLGPKGLEGVITGRAIYSGSLDFKTAVDWIAKQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQU8</accession>
    <name>D6SQU8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870438.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2518"/>
    <dbReference type="EnsemblBacteria" id="EFI35124">
        <property type="protein sequence ID" value="EFI35124"/>
        <property type="gene ID" value="Dthio_PD2518"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="541" mass="60028" checksum="61E03BADD5AA2DE1" modified="2010-08-10" version="1">MSKIQIYDTTLRDGTQAEDVHLSTEDKVRIARKLDTLGIDYIEGGWPGSNPTDQRFFQEIQNYALNHSRVVSFGSTHSTKKTPENDPNLDALIKSRTKAITIFGKTWDVHVKDALRTTQERNLEIIYNSVGFLRPRVEELFFDAEHFFDGFKANKEFALACLGRAMEGGADILVLCDTNGGTTPMELCRIIQEVQASLPEARLGIHAHNDSETAVANSLLAVDLGAVQVQGTINGYGERCGNANLCSIIPSLELKMGYTCLPENNLSLLTSTSHFVAEVANIGAFHRQPFVGKSAFAHKGGVHVSAVRKNPRTYEHIVPEEVGNKQRILLSDLAGQSNILFKARQYGFQLDKDDPFVLDLLSKLKDLESQGYEYAVAEASFELLLNRTLGRARKYFTLDSYRVLESKSDKKDQPFSEATVMVRVGGLQEHTAATGKGPVNALDSALRKALEKFYPTLAEMHLVDFKVRVFAINDSGTYSGTASRVRVLIESADHNAQWVTVGVSFNIIEASRQALEDSLNYKLFKDDQAKLTKAIKEAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQW2</accession>
    <name>D6SQW2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870452.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2533"/>
    <dbReference type="EnsemblBacteria" id="EFI35138">
        <property type="protein sequence ID" value="EFI35138"/>
        <property type="gene ID" value="Dthio_PD2533"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZE0J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2043867at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="123" mass="14903" checksum="F0C230F2215A5CD4" modified="2010-08-10" version="1">MSFREQMDRLVRSFELNPWQLFLVGWRLILSEIRWNFTRMFRQWEIRQMKKRLDQEKLKLAEAVVSGTSGRQEALNLKDSDLDLVLGQVSFLEEEISHLENELQARRRAFLENRMSRYLGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR09</accession>
    <name>D6SR09_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870499.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2585"/>
    <dbReference type="EnsemblBacteria" id="EFI35185">
        <property type="protein sequence ID" value="EFI35185"/>
        <property type="gene ID" value="Dthio_PD2585"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="144" mass="16802" checksum="D0075FAD87B655F1" modified="2010-08-10" version="1">MRVYLDNCCFNRPYDNQSKLRIRLEAEAKLAIQEEIRKGALKLIWSYILDYENSKNPFRERRNQISTWRKYSTEEIVENKKLLDIARTLRGHGIKKIDTLHIASAIYAGADYFLTTDDGILKKATLIKDTHVTDPIGFIKEVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR54</accession>
    <name>D6SR54_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870528.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0493"/>
    <dbReference type="EnsemblBacteria" id="EFI33170">
        <property type="protein sequence ID" value="EFI33170"/>
        <property type="gene ID" value="Dthio_PD0493"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="204"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="44569" checksum="30C1AB2470C654DC" modified="2010-08-10" version="1">MSVKLLKQNYVNKLKCSKGKEKLKVHDQKCRGLILEVRPTGVKTYFIRYKTLRGRYKQIKLGRATDLSVNQARKLGHKILGDVAMGKDPQQEKKVLQSVPTFEEFVWHEYLPYIKSYKKSWKTDVILLRNHLIPKFGGMHMDQIKRDHIISLHQQCLLADYKPATANRLVVLLRYIFNLALKWDTAGVRTNPTKEVTLAEENNQRDRYLDKNELDRLCKALKESENPLLEPIILMLLLTGARKSEVLKAKWHNFDFERRTWQIPGTDTKTGKTRTIPLSDSALEVLDKIKYVDGCPYVFPNPDTQKPFTAIFRSWDTARKKAGLGEVRIHDLRHSFSSFLINSGRSIYEVSELLGHTQIKTTMRYAHLANQTLLDAVNSVPLNNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR66</accession>
    <name>D6SR66_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870540.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0508"/>
    <dbReference type="EnsemblBacteria" id="EFI33182">
        <property type="protein sequence ID" value="EFI33182"/>
        <property type="gene ID" value="Dthio_PD0508"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y84">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1975542at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8926" checksum="A1F175E55646DDF9" modified="2010-08-10" version="1">MGQMTIYLDPETEQKLKAFLEGSNISKSKWIASLIREQTSREWPEKIKRLAGAWNDFPEAEELRKDLAPDFFREPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRC2</accession>
    <name>D6SRC2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870596.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0564"/>
    <dbReference type="EnsemblBacteria" id="EFI33238">
        <property type="protein sequence ID" value="EFI33238"/>
        <property type="gene ID" value="Dthio_PD0564"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2079765at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019201">
        <property type="entry name" value="DUF2065"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09838">
        <property type="entry name" value="DUF2065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7281" checksum="A8B1BB708758BCD1" modified="2010-08-10" version="1">MQFDLTLFLSALGLAFILESIPYFLFAERMPGILSTLAQQSPSNLRRLGFTGLVLGVLVIFLGQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRE2</accession>
    <name>D6SRE2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870616.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0584"/>
    <dbReference type="EnsemblBacteria" id="EFI33258">
        <property type="protein sequence ID" value="EFI33258"/>
        <property type="gene ID" value="Dthio_PD0584"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2035891at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="263" mass="29892" checksum="084B277AC59BBF10" modified="2010-08-10" version="1">MQIVSFLVSFLMHVALILVTLITFSKRPQEFPEDLTRHVYEVELSHFARQAPEPEPEPEPEPEPDPEPDPEPEPEPEPEPEPDPEPEPEPEPDPEPVPRPDPEPDPEPEPEPEPEPEPEPEPEPEPEPEPEPDPEPEPDPEPTPEEIRQQALAELQEEAEQRRSERPAREPSGALEVYQAIAAEHIKRNWRFPRIGREEDLVVRVQVEIDSGGRILDYSVVEGSGRSEFDSSALRAVEDTSRLPEPPGDIRTLVIDFNLQDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRE3</accession>
    <name>D6SRE3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein ExbD/TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870617.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0585"/>
    <dbReference type="EnsemblBacteria" id="EFI33259">
        <property type="protein sequence ID" value="EFI33259"/>
        <property type="gene ID" value="Dthio_PD0585"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1940365at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15293" checksum="D2F1218269EDE05F" modified="2010-08-10" version="1">MDFDPLGKGYISQTNVTPIVDVMLVLLIIFMITAPMLSQGLEVELPRTTMVETLPHDEDTLVVHVDKEGVIYLDEYEVELNELAGHLQRMIEERDRPVYLRADQDVHYGLVVRIMSAVREAGVERLGVLAELDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRH1</accession>
    <name>D6SRH1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33287">
        <property type="protein sequence ID" value="EFI33287"/>
        <property type="gene ID" value="Dthio_PD0613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="17668" checksum="3B902C35919B65CA" modified="2010-08-10" version="1">MDKFALYMLHIFRLKSPHGLPVNQIAVGFEKIKITLSIQTQLRSSFQSRSKFYRYPGGDLCMPIHNSAEMFPRNTGCFYKIFHLYITRPYIHITQNNAWMRRSTISWNHFCPLYLNATAKSHFCSRRSQRSEVSKNKELCRLLVAEFLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRJ5</accession>
    <name>D6SRJ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33311">
        <property type="protein sequence ID" value="EFI33311"/>
        <property type="gene ID" value="Dthio_PD0638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="52" mass="5847" checksum="B715C4FC9881D242" modified="2010-08-10" version="1">MVTLILFLPGDKGLVPNEEAEKSRSAVGISRTLATRPQVVNSYKFFTRMYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRN4</accession>
    <name>D6SRN4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CinA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870708.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0678"/>
    <dbReference type="EnsemblBacteria" id="EFI33350">
        <property type="protein sequence ID" value="EFI33350"/>
        <property type="gene ID" value="Dthio_PD0678"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="168" mass="17572" checksum="58D526CB230874FB" modified="2010-08-10" version="1">MPIVQSDMSLLADILKKKSIMLATAESCTGGLIGHLITNEPGSSDWYLGGVVAYSNELKISVLNVDRELLDAYGAVSPECAEAMARGAAGLCGAGAALAVSGIAGPGGGTQDKPVGTVCFGWFVLGRTRGEKKLFQGSRKEVKMQSAEYAVQGLVDYLQDMNLEAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRX7</accession>
    <name>D6SRX7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870795.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33443">
        <property type="protein sequence ID" value="EFI33443"/>
        <property type="gene ID" value="Dthio_PD0777"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZRWH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2085447at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="72" mass="8435" checksum="B8823D4E90E49455" modified="2010-08-10" version="1">MRSTLTISIPEDVRQELDRTSQEDGVSRSAIVQQSLRDYLFLRRFRDLRGRMVQKAAERGVFTDEDVFEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRZ6</accession>
    <name>D6SRZ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870814.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0796"/>
    <dbReference type="EnsemblBacteria" id="EFI33462">
        <property type="protein sequence ID" value="EFI33462"/>
        <property type="gene ID" value="Dthio_PD0796"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="3">
        <location>
            <begin position="259"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="393" mass="43737" checksum="011DF638F91E8D9E" modified="2010-08-10" version="1">MTSEQIKILVVVPVYNHGDTLRKVVTDILAIHPDVLVVDDGSIDGGVETISDLQVHVRTHEKNRGKGVAIRTAAESARSLGATHIITIDADGQHDPRDLPVFFAAITSSPLAVIVGSRNFETLNVPASSRFGRRFSNFWLRVQTGQKLQDAQSGFRAYPTALFSHLRFTEDRYSFEIEVLVRSAWAGIELLDVPIDVYYPPPAQRISHFSSFKDNLKISWLNTRLTIRSMFPWPHRRIVERGSGLASISVIRPIRSLKILLREEVTPAGLAKAGFLGVFLGTLPLIGIHTVAVLFVAGYLAWNRVTAVAASQLCMPPFVPALCIEVGHYIRHGRFLTEFNLQTLGYQGLERIWEWILGSLVLAPVLASLVAVVIFGMSWIISKQMRIFLNSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS09</accession>
    <name>D6SS09_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870827.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0809"/>
    <dbReference type="EnsemblBacteria" id="EFI33475">
        <property type="protein sequence ID" value="EFI33475"/>
        <property type="gene ID" value="Dthio_PD0809"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="77"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="438" mass="48534" checksum="03E640565119E1E0" modified="2010-08-10" version="1">MTWKHAFSPGLEFAAPEKIYKRQLALLKNHVQYLSRNSRFYRKIFTDSGLDQESIAQLDDLRKFPITSKSDLEGYTQDFLCVAEEEVADLCLTSGTTGHPAALKQTRGDLDRLAFNEETAFGAAGIHKRDKVLIAAAMDRCFMAGLAYFMGLMRIGAAIIRAGSSSMPVLMDLVQSHRPTAMVGVPTLMLTVAQRLAEKGEDPRSLGMQRLVCIGEPVRNQDFTLSPLGKRLQEFWGAKIFGTYASTEMATTFCECEQGKGGHFHPELIVVEILNKDGEPVKQGESGEVVTTPLQVAGMPLLRFRTGDMAVLHTDPCSCGRSTPRLSPILGRKCQLLKIKGTTVYPQAIFSVLQEIPEVVNFYIEVTGRFALSDHVRVVAGTRSPGLTSLMVAERIASRIRIKPEVVLTDPEAVQTRTMVQGKRKPATFFDLREELYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS30</accession>
    <name>D6SS30_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0830"/>
    <dbReference type="EnsemblBacteria" id="EFI33496">
        <property type="protein sequence ID" value="EFI33496"/>
        <property type="gene ID" value="Dthio_PD0830"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="4">
        <location>
            <begin position="311"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="412" mass="47428" checksum="EDD7CC8F4207E63B" modified="2010-08-10" version="1">MSAGIVFIVNTRVTTIYLLNKNLFPGVLNTIDKAPAGIKNTAGMLPGFSLLIILLLCFIMLPGPAPASHPEDIESEIESRREEVSEHKRTLDRLSTREREVYSRLAETEDRLDEISRDLQNQEEKLADLQAREARIFQEYQDLSRERDKTRSRARDIMADLWPIYIESRSQGLADMQDWAEMDRQVQWLRAIHQEMNITLARLHEQTRQITGRLADLQSAKEDFEDQLGDVNALKDRLLEKKLKFVRELQEIRAEKLAREEMVEEIMDVIESLNYRLKVVTEREFEELKGHLPWPASGEVKMSFSPSDSPPHNGKSISLEENAPVRAISWGKVVHNDTLRGFGRVVIIFHGDDYYSLYAYLSESTVAIGQDVEQGETIGKAGYYPEINTHGIYFELRLQQKPINPDDWLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS49</accession>
    <name>D6SS49_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870865.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0849"/>
    <dbReference type="EnsemblBacteria" id="EFI33515">
        <property type="protein sequence ID" value="EFI33515"/>
        <property type="gene ID" value="Dthio_PD0849"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031FC5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926934at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8634" checksum="172A399FE2E34751" modified="2010-08-10" version="1">MLTIKCSGCKKKLFKYRKVGSGEVLRCHKSRITRFYDGLEQKGGLACPCGQVVGIDQGRFYKMNSSAFTYTGTKDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSA6</accession>
    <name>D6SSA6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870922.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0906"/>
    <dbReference type="EnsemblBacteria" id="EFI33572">
        <property type="protein sequence ID" value="EFI33572"/>
        <property type="gene ID" value="Dthio_PD0906"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ZNR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891315at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="83" mass="9279" checksum="12887C108475AAA2" modified="2010-08-10" version="1">MGTVKTIGKSGQVSLGKKFAGQQVLVDEIEEGVWICKVGRFIPESEQWLHAPKIKEELDLAIDWAEKNPPRTSDLSSIEEQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSM0</accession>
    <name>D6SSM0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Molybdopterin dinucleotide-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871035.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1025"/>
    <dbReference type="EnsemblBacteria" id="EFI33686">
        <property type="protein sequence ID" value="EFI33686"/>
        <property type="gene ID" value="Dthio_PD1025"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02780">
        <property type="entry name" value="MopB_CT_Tetrathionate_Arsenate-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037946">
        <property type="entry name" value="MopB_CT_Tetrathionate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="8">
        <location>
            <begin position="58"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="855" mass="96452" checksum="38D2827A7F694152" modified="2010-08-10" version="1">MKQMNIGGSEDHGGSTRISRRTFVKGAAVTGAGLAMGGPTLRALSTDTAHAAPGVMQGEWKSSFCTGCTTWCSLQVFVVNGRAIKMRGHEHSQTNSTYCCPRAHLALQQLYDPDRVKTPMKRTNPNKGKNEDPGFVPVSWDEALDMLADKIMELRDNRETHKFVLFRGRYTAVNSMFYSSVPRIIGSPNNISHSSICAEAEKMRYFLDGQWAYMQYDMPRTRYVLSWGADPLVANRQVSTALRDWGEVLDNARICSIEPRLSGTGSKCDEWLPVKPGYDGALACAMAHVILTEGMWYKPFVGDFKDGENRFVQGETVDEDTFEENHTHGLVRWWNLHVKDTTPEWAEKLCEVPADQIRRVALGFADAAPRCMVWVGGGPGMQPRGSYASMATYALNGLTGGIDNEGGVLAYNSNNYHGLPSHDDFIDSIAEEGNQKEKIDQRGRLEWPNLARGVSGGGVNTNNVADAMLDEDPYLPKVGMGYFANFNFSCPGTQRWAEAMKKFEFFAHMTTHASEMSWYADVVLPVKNCMYEQWATLSHSSHRHTSAAISSPMVDSIWDAKAMETEIPWMLAEKLAERGFDNLLNFYKTFKDPETGREPTTGEELDLYSLKIRTQRYWDPSKHQGGDRFNSWDEFKEVGCWNSDEYEYRHRWSNMGTKTGKFEFYSETLKEALEKHAERHNVSVDRVLEVCNYEARGEMAFIPHHENPYEWGDPEEYPFKFVDYKSRLNREGRSANCAWYNEMKDVDPGDRPYEDVAKLNPRDAERLGVKDGDKIRLTTPIGNIVTTAALWEGCMPGTVAKCFGQGHWAYGRYASKVFGQEPHGANNNDIIPADNDRLSGSTAFYGHIRLKVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSN0</accession>
    <name>D6SSN0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyl-accepting chemotaxis protein MCP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871045.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1035"/>
    <dbReference type="EnsemblBacteria" id="EFI33696">
        <property type="protein sequence ID" value="EFI33696"/>
        <property type="gene ID" value="Dthio_PD1035"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2145054at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="18369" checksum="F365926AE9578862" modified="2010-08-10" version="1">MKMKIMAPVLILLGAGLAVLALQYTDIFNWEKEEETLELTEAQMGMFLDLERKVKAVRQSVQNGILAQDEDFLIQASNQSLEVFDLIDSLTDTFPEAEGLEEAYQDFYASLVSIITLFLENRLEPGRARLMEMEESHAFIDNKLRGIVATVTGEGCLPCFQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSN5</accession>
    <name>D6SSN5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/antitoxin, MazE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871050.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1040"/>
    <dbReference type="EnsemblBacteria" id="EFI33701">
        <property type="protein sequence ID" value="EFI33701"/>
        <property type="gene ID" value="Dthio_PD1040"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="82" mass="9224" checksum="A4342C4E5560EE50" modified="2010-08-10" version="1">MKLQISKWGNSLAVRLPVECTRSAGLQEGDIVEASITPAGAITLIPERNFDKAAFLERIARLHASMHMTEPVVENMRQEERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSR1</accession>
    <name>D6SSR1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD1066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871076.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1066"/>
    <dbReference type="EnsemblBacteria" id="EFI33727">
        <property type="protein sequence ID" value="EFI33727"/>
        <property type="gene ID" value="Dthio_PD1066"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="122"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="38194" checksum="E8246F0C4AF05DFC" modified="2010-08-10" version="1">MKVLVVEDDKISRKTLSLYARNTGYEPIAAADGKEALKLWHEHRPRIILTDWNMPVMDGLELISRVRASEGDEYTYIIMITSRDDSTDLIRGFESGVDDYLTKPVDKSELLVRLKASERIFSLQSKDTVIFAMAKLAETRDPETGLHLERIQSYCRIVSEFLLRNSMYQDIVNRRFIDDIYSTSPLHDIGKVGIPDHILLKPGRLDEEEFEIMKTHTTIGYDTLKSTIQQNPKANYLRMSADIARYHHEKWNGSGYPDGLAGEDIPLASRILAVADVYDALASKRVYKDAFSHEKTRAIIRDGKGSHFDPTLVDVFLECEDEFIETLERFREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSS0</accession>
    <name>D6SSS0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871085.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1075"/>
    <dbReference type="EnsemblBacteria" id="EFI33736">
        <property type="protein sequence ID" value="EFI33736"/>
        <property type="gene ID" value="Dthio_PD1075"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="263"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="333"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="399"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="647"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="765" mass="85070" checksum="9744447361F5E893" modified="2010-08-10" version="1">MQDHSILLVGLETLDREKVLQALEDAGFVKSRVQEVHSGEEAVRVFRETPFDLVLAEQSMEWMSGLELAGLICDDKWKRETRVVLLAGVDDLGQRDVKKAARTGVDDIIFKPLNHQTLPARLSFLVSKNAHASGCQLHICSTASKSGLGYWEYNSLTGGFFYSQSVYEILGYPRGHEPLDNYILHTHLEPGHMQQLEKKVSSLAPKEWFSGDFCFRRRDREERFLRISGQKDSLSKAGIVSGVLQDVTQQKRVEDKLMELLEQTSMQAEALEQSGEGIVLTDSRLNVVYVNPFFDETSGFRASELIPKLRELIPGISLKNNGVADDDGWKRPWREQVNLRDKSGYVREVEVSVSPVKNKKTGEIVNYVLMIRDITERQNLQKQLQQAQKMEAIGTLAGGIAHDFNNSLMGIQGFTELALMNMSDEGRPREYLQSSLRTVQRARDLVQQILTFSGQKETTKAPMQVKPVLKEAMKLLGATVPVNIQLNVDIGDDPPMVVADPVWIHQIVMNLCTNALQAMPRGGNIDVGLKGADLDATCQEAGHDLPRGRYLLLEIQDTGCGIEPEMQERIFDPFFSTKPRGKGTGLGLSVVHGILQELAGRVMVYSTPGQGSLFRVYIPAVPVEQGIPAESDKGREPSGEVVRGRGSILFVDDQEEIVNWGVRALESLGYMVCGFSSGDRAWEVFKEQPEDYDLLVTDLSMPGTSGQELARKVKELRPGLPVIMCTGHAGADTPEKSALQVDALMQKPFSMGEFSRLIRSLLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSS1</accession>
    <name>D6SSS1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871086.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1076"/>
    <dbReference type="EnsemblBacteria" id="EFI33737">
        <property type="protein sequence ID" value="EFI33737"/>
        <property type="gene ID" value="Dthio_PD1076"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="135" mass="15154" checksum="ABCC434C58F3B884" modified="2010-08-10" version="1">MRILIVDDDFITRKSLIKMLQAYGDCDEATNGQEAVDSFNMAWEESRPYDLVLLDIMMPSLDGQDALQQIREFESSRGIMGFGEAKVIMVSALDDPRNVVQAFYAGGASSYLIKPVQAQKLYEEMEKLGFASRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SST4</accession>
    <name>D6SST4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FxsA cytoplasmic membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871099.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1089"/>
    <dbReference type="EnsemblBacteria" id="EFI33750">
        <property type="protein sequence ID" value="EFI33750"/>
        <property type="gene ID" value="Dthio_PD1089"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2002498at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="131" mass="14847" checksum="70D58434760F7B97" modified="2010-08-10" version="1">MFLKIFAAFVILPIVEIYVLIKIGSHIGALWTIALVVATAFVGAFLAKMQGAYTMFRLRTNLQQGIPPTHDILDAFLIFAAGLVFLTPGFITDLMGLLVLIPQTRKIIRVWLVKKIDLWMRQGNVHVIRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SST5</accession>
    <name>D6SST5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871100.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1090"/>
    <dbReference type="EnsemblBacteria" id="EFI33751">
        <property type="protein sequence ID" value="EFI33751"/>
        <property type="gene ID" value="Dthio_PD1090"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="459" mass="50522" checksum="DDDFE6E180A816CC" modified="2010-08-10" version="1">MPEKGSYRTIWTLAWPQLLMMFFHFLIGFVDVWVAGRLGREVQASMGMITQALFFFLVVAIALANGSVAAISQSWGAGLMLRVKRYIGLGLEIGVCLGFVFLAAGLLLKDVLLDLLQLSDEVLPVAGYILQVFLYILPGYYLLIICNAMFRAQQKVMIPLYSMMIVTVVNTFGDFALGLGWWGFPMLGYKGLAWTTFGAVLCGVLFNLFILYRQGFLKRASFAPWRWIKRAWPYLFKVAWPAGLVQVVWHSAYLVLFAITAALPVGSVVALAGMSAGLRVESLLFLPGVAFNFTASILVGNCLGRGDVQGAKKIGYQVMLVALVSVSLLTIAMWQVIEPVAGFVAPDPEVSREAVNYLQYNMAAIPFLLVAMVLGGALTGAGATLYQMFGMGAASWLIRIPLAYILGHLVIQEATGVWMAMFISMVFQAGIMLYLYQFTNWANFAQKKGKRKHSGGPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SST8</accession>
    <name>D6SST8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD1093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871103.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1093"/>
    <dbReference type="EnsemblBacteria" id="EFI33754">
        <property type="protein sequence ID" value="EFI33754"/>
        <property type="gene ID" value="Dthio_PD1093"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="304020at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="460" mass="51512" checksum="65831B487C56CDFE" modified="2010-08-10" version="1">MEFKTRNCWEVYKSKKHRGAMDKMARRYVEFLSRCKTERETVEWVRSRAVESGFSEDWSSDKVFKVHKGKSIFLAWKGKKPLAQGVRLLGAHADTPRLDLKQRPVYEECQVSLAKTHYYGGIRKHQWLARPLALHGVIIKTDGTRIDVNIGEKESDPVFTVSDLLPHLAQKQIEKKLSQAFEAEKLNVVLGHMPYSRDTKDSGEEGEKKAVKKNVLHLLNQKFGIVEEDLYSAELQAVPAGPARFVGLDQGLIGGYGHDDRVCVFTGMEAFLQKGEPQYTRVAIFWDKEEIGSEGSSSARSLFMQYCLEELLENWEPATRPRTMYSATRAVSADVHAAMDPDYQDVHEKLNASLIGHGPVFCKFTGHRGKVGANDAHAEYIGWLRAILNRAGVPWQMAETGKVDLGGGGTVAKFLAVYGMDIIDFGPGVLGMHSPFEIVSKADVYAAYLAYSEFFKAGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST95</accession>
    <name>D6ST95_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871260.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1250"/>
    <dbReference type="EnsemblBacteria" id="EFI33911">
        <property type="protein sequence ID" value="EFI33911"/>
        <property type="gene ID" value="Dthio_PD1250"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="27532" checksum="88D0FB0A7BC87E74" modified="2010-08-10" version="1">MLSRDLPVEEARQQMADNLDKVRKKIEMALQKSADPAREVTLVAVSKRQPLDRIRALAAAGQVHFGENYVQEGLEKIKDLENLEIKWHFTGSLQSNKARFIPGHFSLVHSLDSVKLARALQKKAAELGIVQPVLIQVNLAGEVQKAGVDPDHVPELIQETGRMDHLDVQGLMLMPPLADDPEESRPYFTGLRKMRDTLEQETGRRLPHLSMGMSQDFVQAVEEGATLVRVGSLLLGPRPGCTFNAYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6STB5</accession>
    <name>D6STB5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1270"/>
    <dbReference type="EnsemblBacteria" id="EFI33931">
        <property type="protein sequence ID" value="EFI33931"/>
        <property type="gene ID" value="Dthio_PD1270"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10864" checksum="41EA948B8A8AF800" modified="2010-08-10" version="1">MKIKWDEDKNEWLQENRLISFEEIKGMLLRGEYLDIVENPARDNQMYFVLLIQGYTWLAPFVIDESDELIFLKTAFPSRKYHKRYQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6STM2</accession>
    <name>D6STM2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871387.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1377"/>
    <dbReference type="EnsemblBacteria" id="EFI34038">
        <property type="protein sequence ID" value="EFI34038"/>
        <property type="gene ID" value="Dthio_PD1377"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2050363at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="204" mass="22443" checksum="4875CFEA710BDE56" modified="2010-08-10" version="1">MEAFLASLFAVGIAEVGDRSLFLAILLGVQFKRPWPVFWGMVVGLFTNQALSALLGVWLFSIISPEWQGWIVGTVFLVMAIWVLIPEDDKNFKQRSTGSIFLASALAFFLLEMADKTQLAVITLAGAFETFWPVVAGATLGILAVTTPALWLGSRFAARLPMKFIKISACSLFLLIGCWVLLDTAGLLPQNSFFQPANFFEDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6STP7</accession>
    <name>D6STP7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1402"/>
    <dbReference type="EnsemblBacteria" id="EFI34063">
        <property type="protein sequence ID" value="EFI34063"/>
        <property type="gene ID" value="Dthio_PD1402"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="316"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="387"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="453"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="693" mass="78279" checksum="5EAAE4A8C9AADF56" modified="2010-08-10" version="1">MTDRLKSFLFRLRFRTKITLGMAAMLILSCVIIGLTLSNMASTALLEEGKKRGSALSSGLAFRLAEPILATDFLQMKNLIDNVHTQYEDVVYVFLIDTEGNVLSHTFTGGFPTDLLQVNMDPSDPQPLLLSTEKGTIYDCASPVLLGDRNLGTVRLGLSRDHLEILIQRQRWTALLTTLGVLTLGLVLSSWFATTVTRRLNKLRWSAEEVVQGNLDIQTSSEPRRHCWEIMQCGKQECPAYADTRRRCWYIPETLCEDCQNIGHRQKIENCRKCRVYRQLVGDEIQDLSEAFDVMALTVKNHINELIEREKTIVQQQGLLKTIMNVTPDFITLQDRNLKYQFASKAFCDYFDLKEDDILGRTDFEIFPEEQADSNYHEDRQILSTGRPLSKEVTLSRKGREVWMHVLKVPVYDQEKNIIGLLLTARDITMLKKYQEQLIQSQKMEDLGRLAGGVAHEINTPLGIILGYTQLLLEEVENDEWAEDLKTIEKQTKICRKIVADLLGFSRYSQSTSQPVDMNRSLEEVIKLVEHVLSLSHIRIYKSLDPNIPPFVGDHERLKQVWLNLINNAADAIGQDGVIYVKSKLCAHRQRIIISIADTGAGIEEESLSKIFDPFFTTKSVGKGTGLGLSVSFGIIKDHGGDISALSPPPVEYLPRDFPRSPSYGPGTVFIVELPLEGKTLEKENEDGGHCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6STW3</accession>
    <name>D6STW3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871478.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1471"/>
    <dbReference type="EnsemblBacteria" id="EFI34129">
        <property type="protein sequence ID" value="EFI34129"/>
        <property type="gene ID" value="Dthio_PD1471"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="147" mass="17130" checksum="A3756BC903CBE1ED" modified="2010-08-10" version="1">MKPVTDFPSPETRHPHRVSYGETDAMGVVYYSNYLHWFEKARSTYIRERGIGYTEIEARGVYMPVTEAWCKYLHPCRFDELIYIRAAICDWGKASFSFKYEVLGPDQDRVHTLGRTEHVCMGSNGRPVRVPAWLKEMCMDRPTEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STY2</accession>
    <name>D6STY2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871497.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34148">
        <property type="protein sequence ID" value="EFI34148"/>
        <property type="gene ID" value="Dthio_PD1490"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1880276at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="98" mass="11413" checksum="538A2E52FF3BE2F1" modified="2010-08-10" version="1">MSELKLKAEHPEKASEILFDALTMEKSRLQYSLELSRKRLAEFEKKYNVSSLDFLENWSAEDLEGQDMEYVKWAGEYRLASSLLQRIDILNGITHANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU11</accession>
    <name>D6SU11_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871794.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0417"/>
    <dbReference type="EnsemblBacteria" id="EFI33102">
        <property type="protein sequence ID" value="EFI33102"/>
        <property type="gene ID" value="Dthio_PD0417"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="10176" checksum="B7FB75574BA791E5" modified="2010-08-10" version="1">MRLVFDDHAFEDFSWFISNDPKLAKKTIALIQDIKRTPFKGIGKPEPLKHELSGCWSRRINTEHRLVYQVTEEEIRILACRYHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU21</accession>
    <name>D6SU21_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871804.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0427"/>
    <dbReference type="EnsemblBacteria" id="EFI33112">
        <property type="protein sequence ID" value="EFI33112"/>
        <property type="gene ID" value="Dthio_PD0427"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="14777" checksum="BDC92FF07FA70145" modified="2010-08-10" version="1">MPHIHVTCAIIERNGLVLAARRSALMQLPLKWEFPGGKIRAGEDPGECLKREIREELALEIDIAGELSPATHHYPDFIVTLYPFICKAKTSGFKLAEHAEAAWFPPGELTGLDWAEADLPVLDAYLATLERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU55</accession>
    <name>D6SU55_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871531.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0142"/>
    <dbReference type="EnsemblBacteria" id="EFI32835">
        <property type="protein sequence ID" value="EFI32835"/>
        <property type="gene ID" value="Dthio_PD0142"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="289" mass="32127" checksum="D3B977986DD14E25" modified="2010-08-10" version="1">MKGIILAGGSGTRLYPITRGISKQLLPIYDKPMIYYPLSVLMLAGIQDILIISTPDDLPNYQRLLGDGSDIGISLDYTEQPSPDGLAQAFLLGENFIGTDRVCLVLGDNIFYGQNFTPKLRQAAQRETGATVFGYQVNDPHRFGVVEFDSSKRAISIEEKPQKPKSSYAVTGLYFYDNDVLDIARQVKPSHRGELEITAVNQAYLKRGDLYVEMLGRGFAWLDTGTHESLLEAAQFVETIEKRQGFKIACLEEIAWRNGWLSNTDLEKAGKALAKNGYGQYLLGLIEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU74</accession>
    <name>D6SU74_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871550.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0161"/>
    <dbReference type="EnsemblBacteria" id="EFI32854">
        <property type="protein sequence ID" value="EFI32854"/>
        <property type="gene ID" value="Dthio_PD0161"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="843731at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="282" mass="30726" checksum="7983FBABAB797547" modified="2010-08-10" version="1">MNAISLQARNALMGASTRFSDDKISTLHQALKMETNPNARWVLETILENAKIARESQRPMCDDTGIPHVLLEVGGSRSVGADTLESIQQGIALGMRELPCRPMAVKGDDVQRLEQSAGLDDDPGALALAPVRIRRVDEDVLRLHVLMQGGGPEIRGKTYRVFHQHKLSVIVDEIVNWATEGAALLGCTPCTPAIGIGRTHFEAASLMLDAMTFARFDTQNPIEQEITERINQSNIGPLGLKGRTTALATFLRVGPQRASGVRIVCLRLCCCMEPRVAGVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUE7</accession>
    <name>D6SUE7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ORF">Dthio_PD0241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0241"/>
    <dbReference type="EnsemblBacteria" id="EFI32927">
        <property type="protein sequence ID" value="EFI32927"/>
        <property type="gene ID" value="Dthio_PD0241"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="171" mass="18391" checksum="C2B8A7BB177EBFCD" modified="2010-08-10" version="1">MAANNALNSCSSTSAAGSQEQWRVLMQEALKEAGKARSRGEVPVGAVLADAGTGEILAGGSNRCIELNDPTAHAEIIALRRAGQARGNYRLPGTVLAVTLEPCLMCLGAIAQARIDGLVYGPRDPGAGALFSRPDILDFVWLSHKFWIVENILKDECLELLQNFFRDKRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUF8</accession>
    <name>D6SUF8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871631.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0252"/>
    <dbReference type="EnsemblBacteria" id="EFI32938">
        <property type="protein sequence ID" value="EFI32938"/>
        <property type="gene ID" value="Dthio_PD0252"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="11560" checksum="D1567B9F2C8CDAAE" modified="2010-08-10" version="1">MPNPVTDNNFEEEVLKCELPVLVDFWAPWCGPCRAIGPVVEELAQEYTGRLKVLKMNVDENPGTPGKYGIRAIPTLILYKGGDVMEQVTGAVSKANLKQMIDKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUL6</accession>
    <name>D6SUL6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsE</name>
        <name evidence="12" type="ORF">Dthio_PD0310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="8">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871689.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0310"/>
    <dbReference type="EnsemblBacteria" id="EFI32996">
        <property type="protein sequence ID" value="EFI32996"/>
        <property type="gene ID" value="Dthio_PD0310"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI32996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="164" mass="17331" checksum="D9DEE5C2C5BB887A" modified="2010-08-10" version="1">MQQNDLELIEKIVYLNRVAKVVKGGRRFRFSALVVVGDGQGTVGYGLGKANQVPEAIRKATEKAKKSMVRMVLSGSTIPFQVTGRYGAARVLLKPASEGTGIIAGGPVRAAMEAAGVKNILTKAIGTNNPHNVVKATVEGLSQMTSPEHVSGLRGQSVEYASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUL9</accession>
    <name>D6SUL9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="7" type="ORF">Dthio_PD0313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871692.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0313"/>
    <dbReference type="EnsemblBacteria" id="EFI32999">
        <property type="protein sequence ID" value="EFI32999"/>
        <property type="gene ID" value="Dthio_PD0313"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="126" mass="13985" checksum="ED6E85A44C7502D0" modified="2010-08-10" version="1">MSVDPIADMLTRIRNAHTALHREVKMPSSKAKKAILEIMADKGFIQDFKSDGRTIQVRLKYYGSRPVIKGLNKISKPGRKVYSQAAEIPLVRNGLGICIVSTSRGVMDGMEARKQNVGGELICEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUR7</accession>
    <name>D6SUR7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871740.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0361"/>
    <dbReference type="EnsemblBacteria" id="EFI33047">
        <property type="protein sequence ID" value="EFI33047"/>
        <property type="gene ID" value="Dthio_PD0361"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="669354at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH26" evidence="5">
        <location>
            <begin position="22"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="351" mass="40785" checksum="1E7321DDD427A571" modified="2010-08-10" version="1">MRTSKKLLAVVVFAMFLSAGFYGCREVNNGQQSEKEHKRQLYFGLAVEGLPEQPQVFQDKENKTGLPVSMVNFFLQWPQDPEEMNFPGKTLEAVHSFGAMAVVTWEPMYYDSHGQEHMIAAGDILQGRYDDYIQGFASRIKDLEYPVIIRFAHEMNLDRYHWGGSREEYGPESPERYQEMFQYVVKRFRDEDAGNALFAFCPNAGSVPSPEQGAHWNKARNYYPGDDYVDVLGMDGYNWAYTRTMEEHGWQSSWRSFEEIFEHIYSELTSISPEKPLFVFETASPAEGGDRDVWVQNAFETASRWGLDGIIWFQVDKEEDWRLAAGEECRYPGEVRRKLFSPLPDFQRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUS1</accession>
    <name>D6SUS1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871744.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0365"/>
    <dbReference type="EnsemblBacteria" id="EFI33051">
        <property type="protein sequence ID" value="EFI33051"/>
        <property type="gene ID" value="Dthio_PD0365"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="169" mass="19672" checksum="0D9C2616843AC367" modified="2010-08-10" version="1">MNLDLFSAKTKQYTGFALMLLFLMLVTPWAYMHFNQEEVLWRKGQQSFAQGDYEQAAAYYSRALEKGKISYMLLDRLGDSSLATGRPDQARDAFEVLRQRYPDDARVLLKLARAYWSINDSGQALELVDQALELRSDWEYALFLRAQILTSQGRFEEAINIYYRILGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUU6</accession>
    <name>D6SUU6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871769.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0390"/>
    <dbReference type="EnsemblBacteria" id="EFI33076">
        <property type="protein sequence ID" value="EFI33076"/>
        <property type="gene ID" value="Dthio_PD0390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="243" mass="28366" checksum="46D376D2DAD23DC2" modified="2010-08-10" version="1">MKPAHFLVYLLFAFLLAGCAAGYKAPGPGQLLPDYDPKLFGYEIHEQWMMEDGREVILAENTFLFASDEYVLRIGRARDRGLLELKLNEIHRAKMYKLDDFYVYEGIGRHSEDCRWVVEIVRIRENRAHRNIVEIGEDRRKLITRNDDGDRLILAVMARDLDDSEFWGIEQRRVRNLAPNRMDWEHLEYFQVQAARAFQEADKGKHEQQARQAVEMQRVEGMAPEGTVEEPEDDGRVIIDLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUZ2</accession>
    <name>D6SUZ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871842.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32748">
        <property type="protein sequence ID" value="EFI32748"/>
        <property type="gene ID" value="Dthio_PD0036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="190" mass="21865" checksum="B29A987E2CE364F9" modified="2010-08-10" version="1">MYQHHIIIPTTLEKEFAEQLNAKRITKYRQCLTWHEAHTEEAYLLCLEQLGYLILTDKEQSLEEAIVSEISCLEPEGFVASIDPDPDNITWGVLPSYPKQIRKRINKGVSTLRKCPDLVVAEDEIEKLNLEPITIMGRTYPPVEGLTGLIHELQACYEHYFQNTGALKMLWHSFTGKTPWTDANYGMVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV23</accession>
    <name>D6SV23_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0074"/>
    <dbReference type="EnsemblBacteria" id="EFI32779">
        <property type="protein sequence ID" value="EFI32779"/>
        <property type="gene ID" value="Dthio_PD0074"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10676" checksum="DA2B04B62E146C02" modified="2010-08-10" version="1">MFKEVTGEQIRAARALLGWSQKRLAEETYMSQTPITRLERGIVDRVSTLKLVVQTLEEAGIEFVNRPDGTLGVHLLPDRNDSDKQLTENDQHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV25</accession>
    <name>D6SV25_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871871.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0076"/>
    <dbReference type="EnsemblBacteria" id="EFI32781">
        <property type="protein sequence ID" value="EFI32781"/>
        <property type="gene ID" value="Dthio_PD0076"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924690at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="110" mass="12519" checksum="30B8BBA95FBE01BB" modified="2010-08-10" version="1">MTTYSFGDIVLIGFPHTSQSEMAKRPALVIYDSADNDLLLARITSQRYTSQSDYRIIDWQDAGLILESYIRLGKLATIEKKYVLRLLGRLQKQEQDKVLSILKDIVCGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJW3</accession>
    <name>D6SJW3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869288.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3622"/>
    <dbReference type="EnsemblBacteria" id="EFI36166">
        <property type="protein sequence ID" value="EFI36166"/>
        <property type="gene ID" value="Dthio_PD3622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="62" mass="7212" checksum="69BB136BB0E010A3" modified="2010-08-10" version="1">MPGFISKYNAYNKLLMDIMKSELPLETKREITHAMSQENILDGTAKGKELFKQARKANKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJX4</accession>
    <name>D6SJX4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869299.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3633"/>
    <dbReference type="EnsemblBacteria" id="EFI36177">
        <property type="protein sequence ID" value="EFI36177"/>
        <property type="gene ID" value="Dthio_PD3633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="143" mass="16501" checksum="36922B103933F6D3" modified="2010-08-10" version="1">MKFEEYLTPEGEKRWLAWGTGFTGDPRQARFKCDKYVYECDMLATTFWVRTKTGKFEGYPLHLFGGAAWHMKERLACRVALLEIRKARTKPSKHSRTGITLSVSKAKDIQELCRAAFNPARTSHLELMQELDQLFRTGQAPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK01</accession>
    <name>D6SK01_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3661"/>
    <dbReference type="EnsemblBacteria" id="EFI36204">
        <property type="protein sequence ID" value="EFI36204"/>
        <property type="gene ID" value="Dthio_PD3661"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="122" mass="13593" checksum="F1043A61DB53FC5B" modified="2010-08-10" version="1">MCKMAEPEYQPVLHDQKAFLEKAMKRKGFKEAYEELEDEYVLVRELLAARVRVGLTQEEVAELMGTTKSAVSRLEAAGKHAPSVATLKKYAHAVGCHLEIKLVPDARPTKPSTRTARKRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK18</accession>
    <name>D6SK18_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869343.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3678"/>
    <dbReference type="EnsemblBacteria" id="EFI36221">
        <property type="protein sequence ID" value="EFI36221"/>
        <property type="gene ID" value="Dthio_PD3678"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="563"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI36221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="710" mass="80625" checksum="A437E269B8201993" modified="2010-08-10" version="1">MSSNAKDNVQGRPDTSTRSWFAVSIAITVLLVGFLLWHLVYSYQLMVSFREREFVIERSSWQLLLYAESMQMYALVATTSGDINWERNYLETRPQLENVLQKIQELMPSQEVEKIVEEINEHLTVINELEEEVFSLLKRGEKREAYNLLSGWEYTKNRMDFSDRTRDLTELIQKRLQERTAYDTTRLAVLLVLGGLGVLVLSWVVTLRIWRMQVRKKQEAEENISLLLNNSGQGFMLADENLLVDPNYSLECENIFGPRVAGNSLPDLLYPEGGYDREHFAGSLRMLMQEEDDFIQDNIISLLPEQLYVNHKYLKLQYRLISSTQIMLIITDITEKVLLEKEIQEEHKRLSFVVSALENKNDLLETLREYENFLEESRKQQKGDKPSTGPEIDQLFRKVHTFKGVFMQYEMPYTPEALHSVEQGLAEAARGRVEACSTPGSGELLPGQWLLQVLSRDKQVLVDSLGKGFLDSAREVSVSEDSLAGMESKAQELLESHAVPEQVQQGLSQLLYSLKKLRYKSLQLSLGKYARFVQQMADRSGKLLHPLHIQGDDIYFDPRVFNPFIKSLVHVFRNAVAHGIEDPEERLEKGKPESGQIQCRIENTPEGFVLSISDDGSGVDLEGLREKLRESGAYSLEELGLMDEKELLMQIFTPGVSTAAEADKCRGRGVGMDAVSAAVEALGGSIEVKSAADLGTEVVFYLPGQGFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK50</accession>
    <name>D6SK50_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IS66 Orf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0028</name>
        <name evidence="2" type="ORF">Dthio_PD0742</name>
        <name evidence="3" type="ORF">Dthio_PD1752</name>
        <name evidence="4" type="ORF">Dthio_PD2646</name>
        <name evidence="5" type="ORF">Dthio_PD2999</name>
        <name evidence="6" type="ORF">Dthio_PD3713</name>
        <name evidence="7" type="ORF">Dthio_PD3834</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0028"/>
    <dbReference type="EnsemblBacteria" id="EFI32741">
        <property type="protein sequence ID" value="EFI32741"/>
        <property type="gene ID" value="Dthio_PD0028"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33410">
        <property type="protein sequence ID" value="EFI33410"/>
        <property type="gene ID" value="Dthio_PD0742"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34397">
        <property type="protein sequence ID" value="EFI34397"/>
        <property type="gene ID" value="Dthio_PD1752"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35235">
        <property type="protein sequence ID" value="EFI35235"/>
        <property type="gene ID" value="Dthio_PD2646"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35573">
        <property type="protein sequence ID" value="EFI35573"/>
        <property type="gene ID" value="Dthio_PD2999"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36253">
        <property type="protein sequence ID" value="EFI36253"/>
        <property type="gene ID" value="Dthio_PD3713"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36364">
        <property type="protein sequence ID" value="EFI36364"/>
        <property type="gene ID" value="Dthio_PD3834"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI36364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="13566" checksum="C3CEE398338F4E89" modified="2010-08-10" version="1">MIAVSQAKVYLVTGHTDMRKAIDGLSIMVQAQLEHDPFSGHLFVFCNRQRTIIKILYWDTNGFCLWQKRLEKQSFKWPASKQEVMELDARQLVWLLDGLDPVQVRGHKELKFSTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKA0</accession>
    <name>D6SKA0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869422.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3767"/>
    <dbReference type="EnsemblBacteria" id="EFI36303">
        <property type="protein sequence ID" value="EFI36303"/>
        <property type="gene ID" value="Dthio_PD3767"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9107at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140640">
        <property type="term" value="F:catalytic activity, acting on a nucleic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="83"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="921"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="2094" mass="236346" checksum="61263E84F8FCB036" modified="2010-08-10" version="1">MIPSILSRQIHQGLKDFLATTFQSTNPFFHGVLEKFLSTDGSLNKGPYISLQLPFEKGGDQEYFPHVPLGYTPYRHQEKAFARLSGPKPRGTLIATGTGSGKTECYNQPILEYCRVNSGTPGIKAILLYPMNALAFDQASRLAATIWKNPGLRGRVTAGLFVGQSTADPSSTMGEDHIITDKDLLRQSPPDILLTNYKMLDYLLLRARDAALWAANTPETLRYIVVDELHTFDGAQGTDLACLLRRLQSRLGTPAGYLCPIGTSATLGGDDSTDQLIRYAGKIFGQDFDHEALITESRLNADDFLRGELISRVDIPAPRDMDALKPEKYDTPRDFLEAQIQLWTGLDLQAEPDKSQWRVDLGQALKSHVFVHNLLRVVDGQVRSMQHILDELGGKASPQVKSGGPEYASLLLSSLLACISTAKSLDQEELRPFIHVRVQHWYRELRRMVCSVGSSPEIRFSDDLTQDQRNRHLPLLHCRECGQMGWLGRLPLHGAGLQSDLKAIYVDFFSKKPSQRLTSIFPQEQGSRSSFFPGHSMQLCPWCLHLGNKSGDECRGCGQTGTIAVLVPESAVKHCPSCGAHNSLTLLGSRAASLTSVMIGQFMSSSYNFDPKCIAFSDNVQDAAHRAGFFGARTFRFTFRAALQQYVQDRAEGHSLQRISREMPAYMQSRMDAENFAATFMPSNMTWLHDAEHLEKHDCLPSGSDLGSLIARRLRFETVSEYGFSSRIGRTLEKSGASVARPDPERMGLVIEELKMILQNEMEELRMPQGTAGNSGDTSGQSINNNALASFLMGLTVQIKNQGGIFDPDLEEYVKNWGKEYYISQRRKHWMPGFGPKTRTPGFVTTRAGMDRFPQITHSGSRNSWYEWWAFNYFPNLAMRQPGLAQRFYNLVFASLNKHGLVQDRFQDGHHIYGLQPDALQITNQVQQFRCSICGFSLSGAAADHEVWSSMSCLRRGCQGIFDPAERGADYYGRLYIRGRINRVVAREHTGLLDRDTREELEQKFKTPDAQRKPWYPNLLSSTPTLEMGIDIGSLSATLQCSVPPGQANYVQRTGRSGRKDGNALNLTVAAGQAHDLYFFARPLEMISGYVHPPGVYLDASAVLERQFTAFCLDRWVQASPGTDPVPSRLSTVLDTFQRQDRQVFPHNFMEYIQTRQTRLFDDFAGLFHQELSQDSINHLKQFVFGDSQEHPGLGYRILLRLYDLQKERKGLKTQVDRLYREIKRRENSPVRDKNHEDEMDSLRQERSGLMALIRNINSRDTYNFLTDEGLLPNYAFPEQGILLQSIIYRRRKIQQKGQGRYETLNFEYERPASSGLRELAPGNRFYAEGRRVEVDQVDLRTAGLETWRLCSNCPHCEPEARAGGSAVCPRCASPMWTDQGRKQELVRVRQVMANAPDWDSRITDESDQRDPAFYSTQLLVDVDNAAIRDAYQIEHPQHPFGFEFISRAVFRDINFGPQGQNSRSMQVAGEDLEGAGFVLCRHCGKVQKRDGRIKHAFGCPAKDKDSEANFVKSVFLYREFTSEAIKILVPVTGIEASKKRLDSFVAALQLGLRHHFGGSAYAIDHLQTTLSQEPVPDSSLRKQYLVLYDTVPGGTGFLKQLMRSETMLTVLEKAMQALTNCSCHKDPDRDGCYNCLLAYRHSYLMPTTSRQTAQEVLSTILSHRDTLRQVDNLQQIRVEGLGESELEVLFLEGLQSLDRQGWTVELRKEVIRGKPGRFLRLRAQAYEVEPQVELGQAQAVVIPSRADFVIRSARSRQAGRPVAVYADGLAFHRQRMGQDMAQRMALVQSGRFHTWSLTWKDIHGQVRQRQEKVADLLHPGDSPMGRQKFVQLLSQLDLEGCRELHTRDNFSLLAHFLADLRAKDMQNYALAQAVSLLDMSPSQDARDEWLQAVDHVVPDILLQELDARVHESLIGSLNPGPVNLFVLASRNALKSADPSGVRLFCCLDDTEEAQEKTGFERSWINFLRLYNIFQFLPRAFFCTRQGLRQGMYDQLIESFSDQDAGASHALVAREDDPEWQEAFELAGLELHERLSQMRSQGWPAPEVGFELHAGGRVLAEAELAWPEQKIACLTHEQKKDAEILQEHGWTVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKF3</accession>
    <name>D6SKF3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3824"/>
    <dbReference type="EnsemblBacteria" id="EFI36356">
        <property type="protein sequence ID" value="EFI36356"/>
        <property type="gene ID" value="Dthio_PD3824"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="200"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="400" mass="45329" checksum="EA7C103FEF730D81" modified="2010-08-10" version="1">MAKIMQLPEFKRQKVYTLGQRLQEQQPFIQVVLGPRQVGKTTAVLQVKESWGRASIYESADSPAPPGTDWIEQAWQAAEFKTAAEGPVLLILDEIQKVQGWAECIKALWEQRNSLNQIRLVLCGSSSLQIQGGLTESLAGRFELIRMSHWSFVEMEKCFQWDLDTYLYYGGYPGAARLRDDWTRWADYVQQSLVETAIGKDILLMHRVQKPALLRRLYALSCDYAGQIISYQKLLGQLQDAGNTTTLAHYQHLLEGAYLVQGLQKWHGTKIRTRSSSPKWQPRNTALVTSQSGLAPADWRAEAKMWGRLVEIAVGAYLVNQGEEEGVEVYYWREKNREVDFVLKKGNRLAAIEVKSGQFSKAHSGVGAFQKHWPDSKIWIIGRGGLPLVDFMKAGLETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKG3</accession>
    <name>D6SKG3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36366">
        <property type="protein sequence ID" value="EFI36366"/>
        <property type="gene ID" value="Dthio_PD3837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="8089" checksum="3F93F3A423296128" modified="2010-08-10" version="1">MAVFVRFVLGPQQVLDLVEYLPRKIPAWLNFFTFNWVFSFYGGLLNIVLACLVKCRNKALLRRISLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKH9</accession>
    <name>D6SKH9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868324.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35190">
        <property type="protein sequence ID" value="EFI35190"/>
        <property type="gene ID" value="Dthio_PD2594"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="338" mass="39797" checksum="854D5999B9A0B10A" modified="2010-08-10" version="1">MSKIKQAHDKIFKNVFSDRKNALNLLGNFLPANILNRLDLEQMVYEKDTFVQKHLKGYYSDLLVTIPLIDSDESVKVYFLFEHKSFSDPDLPLQLLRYIVEIWTHYRKQHKHGKLPLIIPLVVTHAEGSWKKAKLSDVVDIPGEPFKAYLPDFEYLLFDCIQEDLNVYDLEVELKSLFMLWKFAHRPNFFEIVREVYRMLRQAYPEMEPRDFLIALAQYLYFTRGSEEYEVINEIIQQESSGGINMETIADMLEKKGYERGYDTAYQEKPKWEKQAELKNAQETLIDVATEAYGPLPDMLHEKIKSIKSLENLRALNRKVIRTQSLEEFTELVNRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKJ3</accession>
    <name>D6SKJ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868338.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2612"/>
    <dbReference type="EnsemblBacteria" id="EFI35204">
        <property type="protein sequence ID" value="EFI35204"/>
        <property type="gene ID" value="Dthio_PD2612"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033I7G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2084622at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="9205" checksum="075A561635E67C7A" modified="2010-08-10" version="1">MIREVIRPKTQSYTIEIPSEYLDREIEIIVFPVEPEKQYEARTSGIVRKTSGILAGKAIDPVSWQKRICGEWDSRRLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKL1</accession>
    <name>D6SKL1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868356.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2631"/>
    <dbReference type="EnsemblBacteria" id="EFI35222">
        <property type="protein sequence ID" value="EFI35222"/>
        <property type="gene ID" value="Dthio_PD2631"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2043967at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="141" mass="14952" checksum="58E2B4F9BFFFE004" modified="2010-08-10" version="1">MKLLVPHDGSEFANKTLDKAIEMAKKHGEATISSVVVVPDLCMSFVGMDECNLLENTLQKEGESIKKAVEAMLSEKGLKGEVVIKAGAPEHVILETADQQNVDYIVMGASGKHGAASRGALGGVTCKVINLGKHNVIVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKN0</accession>
    <name>D6SKN0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2652"/>
    <dbReference type="EnsemblBacteria" id="EFI35241">
        <property type="protein sequence ID" value="EFI35241"/>
        <property type="gene ID" value="Dthio_PD2652"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014846">
        <property type="entry name" value="DUF1786_pyruvate_format-lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08735">
        <property type="entry name" value="DUF1786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="359" mass="39552" checksum="81C4FF7632072A5D" modified="2010-08-10" version="1">MDDNFLQGFYFMDQTALCLDIGSGTQDVLYYIPQRELENCPKFILPSPAVMVARRLEELGRRNKSVYLYGYNMGGGFARVLRKHLQAGLKAAVHPEAAYAMSDSPDNVRAMGVEITKNCPPGFAPVYLADFDPGFWQGFLAQAGLEYPEVILASAQDHGFHPGGSNRLGRFEIWRKFLSREHGDLKKLIFDVPPEEMTRLISLKQCMGGGLVCDTGAAALLGALSVPEVEELSQQQGICVVNAGNSHTIAFLVYRGRVMGIYEHHTGMLDGEKLWAQLESFRAGMLTNEEVFEDRGHGCRVLDEAAGMEFGPVFLLGPRRRLLEGFQAHFLCPGGDMMLAGCFGMLKGAALLKGQKFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKV2</accession>
    <name>D6SKV2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868445.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2728"/>
    <dbReference type="EnsemblBacteria" id="EFI35313">
        <property type="protein sequence ID" value="EFI35313"/>
        <property type="gene ID" value="Dthio_PD2728"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="33"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="37912" checksum="39A1D1D275767D52" modified="2010-08-10" version="1">MKPKVLFVASYFESDCISNYTMPFIDRQMESLREAGLDITSFSIESFRSKYNYIKKSRLLRDYLKENRVDIVHAHYSYAGLTCGISKIRPLVVSLMGTDVYGRVGKSLADRTINFINRMIIRLLASRWDAVIVKSEQMKKFISHSNLHVIPNGVDFGKFYPMDRLKAQSLLNLDPHKTLILFGGNPDNPRKNYALAREVFKLVSLEIQDISMIHLKNIPHQEIPVYLSACSCLLMTSIMEGSPNILKEALACNLPVVSVRVGDAEERLAGMDMCRICSYDPMELARNVTEVIGQGLRPDNRSRIQDLEIGRVADRITSVYHQVLEQYRQGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKZ7</accession>
    <name>D6SKZ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868490.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2773"/>
    <dbReference type="EnsemblBacteria" id="EFI35358">
        <property type="protein sequence ID" value="EFI35358"/>
        <property type="gene ID" value="Dthio_PD2773"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="764330at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002812">
        <property type="entry name" value="DHQ_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33563">
        <property type="entry name" value="PTHR33563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01959">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006655">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="324" mass="35040" checksum="5CE4B6F7C33FC070" modified="2010-08-10" version="1">MTKKIYFKAVPFDKSLVTLALESGVDGILAEKNDLEKIQALGRTQALDVQDFNIMSIDSKEDEENAVQRLKAGENVVLARGVEIIPVENIVAQTPQVGMEAATLQEVDTALGILEKGVDYVVVDAESAGELKKIAARVKQDQGRLELIPGRITHISPVGLGHRVCVDTISLLNTAEGMLVGNSSAFTFLVNAETESNPYVAPRPFRINAGAVHSYTCLPGDKTTYLEELAPGSQVLIVSGQGEARSAVVGRIKTEVRPMLLISAEFEGHQGSVILQNAETIRLVGADNRPVSVVNLKVGDQVMCRADEAGRHFGMRIQEDIREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL85</accession>
    <name>D6SL85_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2866"/>
    <dbReference type="EnsemblBacteria" id="EFI35446">
        <property type="protein sequence ID" value="EFI35446"/>
        <property type="gene ID" value="Dthio_PD2866"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="61"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="386" mass="43807" checksum="50A95A11F44A9B77" modified="2010-08-10" version="1">MLKPAPGHFFGNFLRPGFAFLAGMVMLAILAAPIGTLEAKDKISITDNTGRELSIPSQVDRVICSGSGCLRLLTYIQAHDRIVGVDSMEKRDSGINPRPYALANPQFKDYPLFGEFRGHDSPELIAGLDPQPQVIFKVNPDSGPNPDQLQDKTGIPVISLYYGNLTHARDDLDDSLLLMGRVMDEEERAREVIEYFDDLEEDLRSRTRDIPEQDRPTCYIGGVAHRGPHGFQSTEPSYAPFEFLNARNVADELNTEDKRLDHATVSKEKIMIWDPEIIFLDLSTMQLDRGANARDQLQRDPAYRHLSAVAEGRVYGVFPYNYYTQNFETIFANAYYIGSVLYPERFQDIDPMRKAEEISVFLNEDKAFEEMNRQFDGMGFSRIDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL91</accession>
    <name>D6SL91_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nitrogen fixation protein NifU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868584.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2872"/>
    <dbReference type="EnsemblBacteria" id="EFI35452">
        <property type="protein sequence ID" value="EFI35452"/>
        <property type="gene ID" value="Dthio_PD2872"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016217">
        <property type="entry name" value="N_fixation_NifU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010238">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000375">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02000">
        <property type="entry name" value="NifU_proper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="7">
        <location>
            <begin position="134"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="NifU" evidence="5">
        <location>
            <begin position="211"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="281" mass="30712" checksum="D9974151F4490CCA" modified="2010-08-10" version="1">MWEYTDKVKEFFLNPKNAGEISDADAVGEVGSLACGDALKLFLKVDDSGVIQDASFQTFGCASAIASSSVLTELLKGKTVDEASRITNKDIARELGGLPKEKMHCSVMGQQALEAALKNLRGEEAATRDLEGEVVCECFGVTDEEIKRAIRDNNLTSVEDVTHYTKAGGGCEDCHAEIEKLLDQVRSQTLTPVEPVSEERPMTNIKRMQLVTRVVDEEIRPSLHKDGGDIELVDIEGPKVMVSFRGACAGCPSSHLTAKEVVEKKLKERVDSQIQVEEVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLA1</accession>
    <name>D6SLA1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868594.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2882"/>
    <dbReference type="EnsemblBacteria" id="EFI35462">
        <property type="protein sequence ID" value="EFI35462"/>
        <property type="gene ID" value="Dthio_PD2882"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1393323at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="27518" checksum="22325BEA5C70E40F" modified="2010-08-10" version="1">MNSPQYISFSFPGLEKVTCIFGTRLGGVSSGSFGQGNISLDVEDEPARAGANRRALKDELGLSGWVELRQVHGTLVHFDPDEDCLDGSSLEGDGLGLSRPGRGAVIKTADCQPVMLAHKSQEYVLALHCGWRGNRAGFPETAVRDLCKYYNLSPADLAAVRGPSLGPCCARFEPFEEHWTPEFADYYHQEQKTMDLWSLTRDQLLQAGLLPQNVFSLDMCTMCREELFFSYRREKKGGRQASIINIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLB8</accession>
    <name>D6SLB8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2901"/>
    <dbReference type="EnsemblBacteria" id="EFI35479">
        <property type="protein sequence ID" value="EFI35479"/>
        <property type="gene ID" value="Dthio_PD2901"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50336ZC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="11151" checksum="D0585E460896EE44" modified="2010-08-10" version="1">MSLPARGLNTSAVEVTHVSSHGIWILTHDNELFMPYDEFPWFKDQPLKNILNVQEQSPGHFYWPEIDVDLTEEIIRHPERFPLKSKVFSSESHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLC9</accession>
    <name>D6SLC9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868622.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2913"/>
    <dbReference type="EnsemblBacteria" id="EFI35490">
        <property type="protein sequence ID" value="EFI35490"/>
        <property type="gene ID" value="Dthio_PD2913"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="247" mass="27634" checksum="54A967B9460E3AA0" modified="2010-08-10" version="1">MHVQCQIKASLKSGKENFSLEADFDTSSSSIVLFGPSGAGKSLTLMALAGLQTPDSGKIVLDGRTLYDSAKKINIPARKRKVGLLFQDYALFPHLTVMDNVGFGLKRSFRPLKVQQKNKIYQYIQMFGLENHTDKKPHELSGGQRQRAALARALVSNPDLLLLDEPFSALDQPLRIKMRSELGNILEKFNMPMIMVSHDHQDVEAFGETLVSFGHGRVLDVLDYQSRRRQGQDVMDILTPLYQTASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLF4</accession>
    <name>D6SLF4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2939"/>
    <dbReference type="EnsemblBacteria" id="EFI35515">
        <property type="protein sequence ID" value="EFI35515"/>
        <property type="gene ID" value="Dthio_PD2939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="52" mass="5782" checksum="687D21B9B6585A3F" modified="2010-08-10" version="1">MGQYRPAGIAHNYPELLGRVSGNQVETLNKKARKLGLTNLDQRSSGIFRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLK7</accession>
    <name>D6SLK7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868700.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2994"/>
    <dbReference type="EnsemblBacteria" id="EFI35568">
        <property type="protein sequence ID" value="EFI35568"/>
        <property type="gene ID" value="Dthio_PD2994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="623" mass="66787" checksum="F78E5EA5FDD065BE" modified="2010-08-10" version="1">MEGGGQAGDYDDTIRIAKPGHITEDAVLDGNGGQNTLQFGDKDSYDLTDLDEFANIHTLDLRNIDDTATMTVDQSNGVTVNAFSESLLKVDASDVGEGETKTITFNADMGGGDLIYEFDAGTVELTSDSSLQNIGTLTVTNGTLDVSEIDEAQDFENIENVVVNSEIILTGSQLEGITGFEGSGTVTVLIEDEDDEDQFLTFSDETGFGNASPGVDFNDGEYTLTMTVEQHEQLNHVTRGSQATIEIEFDYSGSDDPIDITGIEGFNGTYRLAGHYFDTNKINKLELGDRLGVEDANRLELITPDKGEISEGRFKIDSFTGSLSDEFVIDVETKTEISDVSNLSLNGHTLKLAGSEEMTLGSYGGSLELSAGSRLETGISDNLDAYLTNSGDAEIVLGSSGAVNNLYIANSSDSGVFTFEFSGGDIGENTIGEASTNWVPVSMSMMTLDNFSDSEVSEDETTVYFDVNDTTIEATATDGTSAQFADDIRDAISAADGDYTDLRVDLVDETLYIIDPHGRAFSSYGRGGTQMSGGDAFRDQHGFDPDSDQLDFTGYFDAIESYTEDYDQDEEIDGALLDDEDNVLVAFKDDGGNVVASSDTFDGDITLVGVNSDDLSFADNFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLS8</accession>
    <name>D6SLS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3068"/>
    <dbReference type="EnsemblBacteria" id="EFI35639">
        <property type="protein sequence ID" value="EFI35639"/>
        <property type="gene ID" value="Dthio_PD3068"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y6G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="90" mass="10052" checksum="A1E8F1962C5643EA" modified="2010-08-10" version="1">MAKCLDEGVDPTHMCQSLVDRISRSRALNSIAEPELLPLFEDWLEELEKEFVRQAEKSQSSDAALMAEKLGLSMAGAQFLKAKLEQEGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLV2</accession>
    <name>D6SLV2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868792.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3092"/>
    <dbReference type="EnsemblBacteria" id="EFI35663">
        <property type="protein sequence ID" value="EFI35663"/>
        <property type="gene ID" value="Dthio_PD3092"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503497N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1511193at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="270" mass="30995" checksum="3EFCAF74AA5F5DC2" modified="2010-08-10" version="1">MAGPPKIIHFPYMHEELVSPGLRPMGLFLNPGIKDPLDIFFTPQGLVLDKGLSEYFLEQCRQFGEQFKKTSDMTHLGMAQMEDFYTGSTQSIQYELSTYGKSDEAKEDHKEDLLQAQQYLLLNFALEERLLELGRIDADLSLSWSSFDESLGIDDEEEHFQNIARQSISPQISTDHWQKLLKAYTAFLPPQGILLVHEESVSQELQEYGIAWERHDPDHFFPGLADRKGLDFFCATLNLDKIDKKKQTFAREVKLLRAVSSTNSLQQTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLX0</accession>
    <name>D6SLX0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="2">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="2">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="2">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868810.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3110"/>
    <dbReference type="EnsemblBacteria" id="EFI35681">
        <property type="protein sequence ID" value="EFI35681"/>
        <property type="gene ID" value="Dthio_PD3110"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="248" mass="28074" checksum="EDF0004E67016981" modified="2010-08-10" version="1">MNRKLTFSIFRYNPQEPGSSPGTQEFRLEETENLNLFVALNLIREKQDPSLQFDFCCRAGICGACAMVINGRPGLACRTKTAELPDKIVLMPLPGFRLVGDLSVDTGAWFRSMNERVRAWIHTDEDFDPDAPEVVMDNHVAEQIYELDRCIECGCCIGACATAQLRSDFMGAAAMNRIARFMLDPRDKRNNRDYFEIVGTDQGIFGCMGLLGCQDVCPKNLPLQDQLAHVRRKMGRQALKNILPWYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLZ4</accession>
    <name>D6SLZ4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="9">ALP N-acyltransferase</shortName>
            <ecNumber evidence="9">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lnt</name>
        <name evidence="11" type="ORF">Dthio_PD3134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868834.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3134"/>
    <dbReference type="EnsemblBacteria" id="EFI35705">
        <property type="protein sequence ID" value="EFI35705"/>
        <property type="gene ID" value="Dthio_PD3134"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1291198at2"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="226"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="518" mass="58759" checksum="670B33723A1DBB07" modified="2010-08-10" version="1">MRLPEIFRQGSFWAQFFMCLAGLFLAFPNPLLQVPFLIFLFFLGLNYIAFNTRSKGEAFRRGLLVSGPAYAVTLYWIVVPVHVYGHFPLVLALFFPLLLGFVLGLFSSLYVFVVHIMSRRFSWIALGVFGGAVWAFLEFAREYVFTGFPWLIAAQAFSIWPESIQAVSIVGSYGLAMLLACAGIWIYQGRTIPVLAALALLFPVLGYGFFLQQKEYDGPAKDILIVQGNLDQDIKWEEEIQMKTVEKYKDLTIQSLDEINADLVVWPETAMPFYLQEQSRMSFMVMNLAQEKGIDLITGAPAYEMQEDGINYKLHNRAFWISGRGLIQDHYDKERLVPFGEYIPWSSYLFFLDRLVAGPMDFSPGKATAPMENEELALGMLICYEIIFPGLVRDRVQQGANVLINISNDAWFGDTSAPRQHLHLSVLRAVEQGRYVVRSTNTGISAFIDPSGRVYESTPLFQEATLSGQVKLLDDKTFYHVWHWHINWILAGISLAGLALCLVVPAKRTFSEKSYINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM20</accession>
    <name>D6SM20_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">xerC</name>
        <name evidence="14" type="ORF">Dthio_PD3160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868860.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3160"/>
    <dbReference type="EnsemblBacteria" id="EFI35731">
        <property type="protein sequence ID" value="EFI35731"/>
        <property type="gene ID" value="Dthio_PD3160"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="111"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="310" mass="35289" checksum="0C25BF45B53434BE" modified="2010-08-10" version="1">MSILAQEHPHARSFLEHALVIKGLAHQTVAAYTEDLSTFLEFLQEKGKDVLDINDQVLLVYLMFLRRKGLQSRSLARHMASLRGFYAYLHEQGLLKDNPAEMLENPKLPQLLPRVLSIPEVESILSQPSTGDKLGARDKTMLEMLYAAGLRVSELINLKVLDFDPQAGIIRVWGKGARERLVPLHFSCMQWLDFYLQHWRSSFSPRVDKVFINRSGKALSRQGVWKIIKKYTVMAGIKKDVSPHTLRHSFATHLLEGGADLRTVQVLLGHSDITATEIYTHVQSDRLKSAHDFFHPRSKNTGKPVHAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM26</accession>
    <name>D6SM26_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868866.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3166"/>
    <dbReference type="EnsemblBacteria" id="EFI35737">
        <property type="protein sequence ID" value="EFI35737"/>
        <property type="gene ID" value="Dthio_PD3166"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="298" mass="32137" checksum="668B43974EE1DB6D" modified="2010-08-10" version="1">MNREFKQELASRAKEIEDYLESCLQFEGVPGELQQAMEYSLMAGGKRVRPVLCLAWGEMTGACTKDILPFASGLEMIHTYSLVHDDLPAMDNDDLRRGKPTSHKKFGEALAILAGDGLLTQAFAMMLKTSFPAENVLAAAGTVAQAAGPAGMVGGQCIDMRATGRESMELVDLKGMHAMKTGALLRAACCSGAILAGSDPENGRDTLNAYNYGSNIGLAFQIVDDILDVTGDEKSLGKPVGSDESVNKSTYPRFLGLEKSRELAQTAADEAKTCLRDYQGQGRDFLYRLAQYIVDRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM92</accession>
    <name>D6SM92_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbon monoxide dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:21040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.4" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868932.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3238"/>
    <dbReference type="EnsemblBacteria" id="EFI35803">
        <property type="protein sequence ID" value="EFI35803"/>
        <property type="gene ID" value="Dthio_PD3238"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="136177at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018492">
        <property type="term" value="F:carbon-monoxide dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043885">
        <property type="term" value="F:carbon-monoxide dehydrogenase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016101">
        <property type="entry name" value="CO_DH_a-bundle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010047">
        <property type="entry name" value="CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005023">
        <property type="entry name" value="CODH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01702">
        <property type="entry name" value="CO_DH_cata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0533">Nickel</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005023-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="652" mass="70707" checksum="C7A99F427BB2FED6" modified="2010-08-10" version="1">MDKPIRSANEAAEQIVRWSDEQNISICFDKAGKMKSCPIGSSGACCSNCHVGPCRLIGSNAEEEATGVCGASLPSIVARNFLRKVVSGTAAHSDHARDMAFTLLAVATGEAKDFRIADEHKLFKMADILEINHQGRDVMEVAKDVATTLIDDFGRQRGEINYLKRAPQKTQERWKKWGVIPRGVDREVCEGMHRTHMGVDHDPDNLLLNAVKVALADGWAGSMISTDISDVLFGTPHPMRGKAGFGMFKDDEVNIVVHGHEPTLAEMIVLMADDPEMQEYARSKGAAGINLGGMCCTANEILMRHGIPTAGGFTNQELAILTGKVDAMTVDVQCIMPALVKLSERFHTKVVTTSDKAKFTGATHVGYEEHRAAEIAKEIIKLAVDNFPNRKKNGYTATDQQDLVAGFSQEYIEYMQGGRMRASFRPLNDAIQVGRIRGVVGLAGCDNPRVPAQGLHRYLAKEFIKSDVLVVSTGCGSHACQAAGYMTPEMALEHAGPGLKEVCEAIGIPPILPLGSCVDNSRILTILTAMAAEGGLSEEIGGMPGVGIAPEWMSEKALAIGTYFAASGVPVIFGGESPVGASNEVTRIMSETWYERFKGAFHFEPDPEKIFDMALKYIDAARDALKLKKYEPGKFGVERVLMDMAARRESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMD9</accession>
    <name>D6SMD9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868979.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3288"/>
    <dbReference type="EnsemblBacteria" id="EFI35850">
        <property type="protein sequence ID" value="EFI35850"/>
        <property type="gene ID" value="Dthio_PD3288"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1997676at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022148">
        <property type="entry name" value="CopG_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12441">
        <property type="entry name" value="CopG_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="105" mass="12339" checksum="EC2154284036193E" modified="2010-08-10" version="1">MKKHNRIPHFENEDQEREFWAHESPLDYFDPNEFKKISFPDLKPSLKSISLRLPEAMIAELKLLANKKDMPYQSLVKIFLARQINVERGSLAKDLENTTDYFEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SML2</accession>
    <name>D6SML2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
            <ecNumber evidence="1">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869051.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3364"/>
    <dbReference type="EnsemblBacteria" id="EFI35923">
        <property type="protein sequence ID" value="EFI35923"/>
        <property type="gene ID" value="Dthio_PD3364"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="683" mass="79165" checksum="59FF2F4C85131B83" modified="2010-08-10" version="1">MNSRVVPVSISHERFGHKSHRFEYRFMVLLLDLDELKRLDENTRLFGFNRYRPACIFQKDYLTPGPESIRDKLGNLLQSYKFMTLDQDSRVLLLTCPRIFGRVFNPVSFYFIFSPAGKLQLTLAEVNNTFGDKHVYILEKSGRSPGFPVQFKTPKKFHVSPFFDISGQYLFSFSDVRKEIDIAITLEKNHRPALEARMWQAARPGELTDGNLLSTWIFHPLASNMTYPRILRQAVSLYYGKGLPVFTRPEPENPLTIRTMQQKSTILDLIARRLVLANLKKFRKGRLEIQMPDKTVHVFGEVEPGPSCRMNIHDPRFFRKVIKGEDVGLGEAYTMGMWDTDNLTRLMELLIMNMGHLSYMENWGAAGRMLHKMLVPARKMIPDNDPRGCRQNIQAHYDLSNDFFAGFLDPGMTYSCAVFENLQELRQTGQPVSQSRLQQAQERKYSMVARAAGIKPGQSIVEIGCGWGGFALFAAREFDCQVKAVTISREQYNYVQQQVINQGLQDRIEVAMEDYRHIQGRFDALVSIEMLEAVGHKYHPRFFQSVDRLLRPGAKACIQSITIPDQRYNTYRKTQDWISTYIFPGGLLPSLDRISSVLARHTTLVIAQVTDIGPHYAPTLAAWREKFLQNWQEIKSLSQCFDEDFRRTWEYYFCMCEASFEQRHIRDLQIVLDRPRYSPGRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMQ5</accession>
    <name>D6SMQ5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="5">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD3408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869094.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3408"/>
    <dbReference type="EnsemblBacteria" id="EFI35966">
        <property type="protein sequence ID" value="EFI35966"/>
        <property type="gene ID" value="Dthio_PD3408"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="7">
        <location>
            <begin position="20"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="328" mass="35905" checksum="2CB643C25A68DF9A" modified="2010-08-10" version="1">MPASKTLTSSPPLTPDSPWLAPLAGYSDLSFRLLCRNLGCRAACTEMISAKGLFFSTANTMRLLETCDQDLPLVVQLYGSDPDIMGRAVSTLSSKGFRYFDLNCGCSVKKVVKTGAGAALLKDTGLLLQMVAAMADMAGPGRVGVKLRLGWSSEQKVYLDLAAPLADAGAGWITLHPRTAVQQFTGKADWQALKNLKEISPVPVVASGDLFTARDALDCVRQTGVDTVMFARGALMDPAIGMRYKNLLQGLEDLPRDQEFTLRLCMETIDTYRRHASSRAVLKLRTLLPRMIRGLPGAKDLRKKIILCRQWAELEEVMNSARKHLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMR4</accession>
    <name>D6SMR4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3417"/>
    <dbReference type="EnsemblBacteria" id="EFI35975">
        <property type="protein sequence ID" value="EFI35975"/>
        <property type="gene ID" value="Dthio_PD3417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="56" mass="6491" checksum="3DB94B1E8579A23C" modified="2010-08-10" version="1">MHLRQTRADTVRVLVHTQRVQVLDSLALMHPEWSMDKAAKASFVRADFQRRSKQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMV6</accession>
    <name>D6SMV6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="10">Glu-ADT subunit A</shortName>
            <ecNumber evidence="4 10">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gatA</name>
        <name evidence="12" type="ORF">Dthio_PD3459</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="4 10"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869145.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3459"/>
    <dbReference type="EnsemblBacteria" id="EFI36017">
        <property type="protein sequence ID" value="EFI36017"/>
        <property type="gene ID" value="Dthio_PD3459"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI36017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="489" mass="53354" checksum="710EEEA91DA8A16F" modified="2010-08-10" version="1">MYQDTRTLCTTRLLLQKKEIKASEVVEEYLDNIRQTEPGIRAMLHIREEEALEEAREMDRQGPDNEKPLWGVPMTIKDVICTRGTPTTCGSRILENFTPGYDATLVQRLRQAGAIILGKTNMDEFAMGSSTENSALQTTSNPWDLSRVPGGSSGGSAASMAAGQSLGSIGTDTGGSIRQPASFCGVVGMKPTYGRVSRYGLVAFGSSLDQAGPMTLSVPDSAAVLNVISGHDPLDSTSSSAPVPDYLDALEKRKDLHGLRIGLPRQYWEEKMSPEVDSACKKVLETIREAGARTVPVDLPHVQHGVAAYYIIAMAEASSNLARYDGVRYGYRDQEARELLDMYRRTRSRALGEEVQRRIMIGTYVLSAGYYDAYYKKAAQIRRLIHRDFMQAFEDCDLLCSPVVPSTAFRLGENVDDPLQMYLTDIFTTSLNLAGLPGISIPAGLGHETGLPVGIQFMGPAFGEELLLQAAGILEQSLPALPFPAALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN11</accession>
    <name>D6SN11_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869200.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36072">
        <property type="protein sequence ID" value="EFI36072"/>
        <property type="gene ID" value="Dthio_PD3518"/>
    </dbReference>
    <dbReference type="OrthoDB" id="998166at1224"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="102" mass="11560" checksum="A524B389F384C7F8" modified="2010-08-10" version="1">MKAIEMETFIHEDGKLPAEFREAFGHKARVIILLKDDTGQEEQIRQDSALFEHSVYHENDDPAIALISGPDDYSVRAEEILSGGLREHSGWTVKEPKNDHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN84</accession>
    <name>D6SN84_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869538.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1561"/>
    <dbReference type="EnsemblBacteria" id="EFI34210">
        <property type="protein sequence ID" value="EFI34210"/>
        <property type="gene ID" value="Dthio_PD1561"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="2">
        <location>
            <begin position="312"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1210" mass="133023" checksum="384192F64DB56FF8" modified="2010-08-10" version="1">MIKFSASQAYLGQSFKDLLEIPEYASNWYRLLLGEETEQDWLGGFVQDTEHGNGWAMRDEISDVSLHDAAGKTLYWQPHGEDWEHAQVDSAHQTASDVFTDPPEWLQIWTGKLDDQNNVVDGGVVDTSEINPHGQGWIESQDLEDLTVTQEQEDHNHVYARTAGGEWQHVQMEFSDAPKLDLYLEQDVVPDDVDTSDGYTLGGFGIPDADPEDSFDYQVTGGADQDVFTIQNGGLVFEAGTEIDYHAQSEYEVEVTGQDQDGNESIETFTVYVTYADGAGNSRAEAREIGVLSQGDTFEHSEDVGRLGDHADYYSFELEDNLDVAVEASGQDETRNAMGLRLYDSQGSLISHSNQDNDQESIAVTLEEGVYYVNVYEYLGRSEDYDLSIRADTFRTADSPEKAMEIGELSPGDSREHSVEVFDRIVREDYYTFTLTEQGQVDISMLFDEDLDQNLGFRILDSDEEHIEFDVSDTGEAFLSQELEAGDYYIEAWPVHGSHEYELNVDVNEPGGTLEDFSSEAGDTELNKTAADKATASNQKKEYFQEESDSLGTEQMDYDFSQSYTENSSLSTENDSSNILNFSDDSIGMWAGEEGVSLDKTFDDFLLDETIEGSPIFETASHELSYNYHTSIKAGLLAELNLETGHLDLDYPVDMDPGVPETVSSGQSFSVDTSDYSLTEATLQSNAPNPNDFGFSVDLIPPQLEMSVSDISLDAPLWSPASSFEYSGFDVDIAPAGDPISLVDGTLGDFELDQDFGPVGFEMGMPTGLELESQPVSSHTLDPVSTQGDDYGTTDDSFVNLGLSLTGLAQNAFGFPDLLESSYDFGVAELGYTVADVSANLGLTFAQDFTFEPGEVEVSMQTQDGQVQTGQLGDDFTFDAPEDSGSMDIDATYTLNGEINNNTGVMPNGSITADVLDAHLEILDFVDIGMDPLYSDEFPDGGWDALDEPLWLYENTFDLELEEDVTYQTEIGDDLPAHLSIDSFGDVSVQESQTVTVAAAVENTGDRETTQNISLSVDDVHLEEEFTIPAGDTRDISFDLDTAEHGLDIGEYDLELDTGDESESVTLEVLPADDESDDDFLEIYDISISPESPGVGESFSVKVKGFGAQSADAVNPSVTLAIPKDDYEHTFNPASLDDGQTEEVIFLEGIVDAGEYKAEVTVDAVNAQSVTEQIEFAIGGSDQDVHYVVTDYEELDFALQDKEIWPGMNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNC3</accession>
    <name>D6SNC3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869577.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1600"/>
    <dbReference type="EnsemblBacteria" id="EFI34249">
        <property type="protein sequence ID" value="EFI34249"/>
        <property type="gene ID" value="Dthio_PD1600"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="260" mass="28314" checksum="C6F1C9E0866C6D1C" modified="2010-08-10" version="1">MIINRELIDDALQAVRGAGEIILKAWDKPRNIRHKGRIDLVTDTDVAVEDSLKKSLGRVLPEADFLAEESAGETELKGGPTWIMDPLDGTTNFAHRIPFVAVSVGLWQGGAVRMGIVHLPVLGEMYWAAQDQGAFLNGEQINVTETQDLVQALVATGFPYTIKTDVDQVLGYMRRALMNTRGVRRCGSAATDLAFTAAGRFDAFFEIGLKPWDTAAGACLIREAGGMVSTMHGQDYFPGQETILGTNKVLHEQMIKILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNH9</accession>
    <name>D6SNH9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1656"/>
    <dbReference type="EnsemblBacteria" id="EFI34305">
        <property type="protein sequence ID" value="EFI34305"/>
        <property type="gene ID" value="Dthio_PD1656"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2052285at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="83" mass="9519" checksum="FB1552B479072EA8" modified="2010-08-10" version="1">MAMQDRIFTLGLSVEAVSLYLILHDLEFHDMPLERENIEPRWNAPPQALEHALDELAMHQVVQDKSDPLTLNPQEAWTPSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNM9</accession>
    <name>D6SNM9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869683.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1706"/>
    <dbReference type="EnsemblBacteria" id="EFI34355">
        <property type="protein sequence ID" value="EFI34355"/>
        <property type="gene ID" value="Dthio_PD1706"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033CKA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923055at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9995" checksum="8DC91348E25C74D1" modified="2010-08-10" version="1">MSETFPEHWEFDDEFDGGEETCGRVIINLYTYLKPMPPGYRILLISKDPAAPYEFPAWCRMTGNALLDMSHPYYLVEYKPQLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNN1</accession>
    <name>D6SNN1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869685.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1708"/>
    <dbReference type="EnsemblBacteria" id="EFI34357">
        <property type="protein sequence ID" value="EFI34357"/>
        <property type="gene ID" value="Dthio_PD1708"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="300" mass="33519" checksum="69CA47CC9D4ACE11" modified="2010-08-10" version="1">MDQRKLQAFLSVYEMKSFSKAGEDLYLSQSTISTHVLSLEQELGVQLFDRIGRRIIPTQAGHLLHDRVRNVFRIIEQTRTDIHDLNNHVCGKVVVGGSTIPANYLLPMVISDFCGQYPQVCVDLRIGDSIEICQEVLAGNLDFGIVGGFVDHFDLEHRLLLKDKLHVVASQDLKLDLPETVFPENLKDLPWIQREKGSGTRNAFESAMMNCGVSLRDLRIAALVQSTEAMVRCVLAGAGVGVTSFLAVQEYLEAGELTIIDVPGLDIVRSFYLIHHKARTLFSCSRMLMNSVEKHIKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNR2</accession>
    <name>D6SNR2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869714.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1741"/>
    <dbReference type="EnsemblBacteria" id="EFI34388">
        <property type="protein sequence ID" value="EFI34388"/>
        <property type="gene ID" value="Dthio_PD1741"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033GEX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2085932at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="133" mass="15131" checksum="5BBF26E3F60E3AC4" modified="2010-08-10" version="1">MLQQSAPATRPGLEEVKRQFEHWRETRHTRSPIPNHLWASAVSLAQDYSICKIAKVLHLNHSHLKKRVLAEQAQESLQPGPSFVEFELTSSLPRTEYHLETEARDGSKLKMQLKGPDLPNPLEILSAFWSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNT2</accession>
    <name>D6SNT2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869731.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1766"/>
    <dbReference type="EnsemblBacteria" id="EFI34408">
        <property type="protein sequence ID" value="EFI34408"/>
        <property type="gene ID" value="Dthio_PD1766"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031ZWK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1638454at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="182" mass="20767" checksum="9A71C14E00BB1AFD" modified="2010-08-10" version="1">MNSVELMHKFRSALPAVREWIEYTLEQNCFAAVSVDTSSFPRLKNVFPIELLVQTKVVVVQGKVPFPPLSQMGLPEFSQMENMSMPGITYKDTFFVNHSHQTESLYFHELVHVVQWERLGLDRFLLAYGAGLMQFGYEGSPLEKMAYSLQLDFDKGVLSANTVEIIQQQTDAVWKQVSLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNW7</accession>
    <name>D6SNW7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="13">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">metG</name>
        <name evidence="18" type="ORF">Dthio_PD1802</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="13"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869765.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1802"/>
    <dbReference type="EnsemblBacteria" id="EFI34443">
        <property type="protein sequence ID" value="EFI34443"/>
        <property type="gene ID" value="Dthio_PD1802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 13 14" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="17">
        <location>
            <begin position="539"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="13">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="13">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFI34443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="640" mass="72865" checksum="1AC95AE1FA9B95D5" modified="2010-08-10" version="1">MESFFVSTPIYYVNARPHLGHAYTTIVADSINRLHRLRQKDTFFLTGTDEHGDKIVEAAEKNGLAPKEYADRISALFKEAWPWLEVENSAFIRTTDPEHVKCVQRFLNTVYENGDIYFGEYGGHYCFGCECFYMEKELQDGLCPDHLEKPRYLKEENYFFRMTRYLPALREHILNHPEFIQPERYRNEVLGMLGDELTDLCISRPKSRLTWGIELPFDSNFVTYVWFDALINYISALGWPHGEAFKRYWPGAYHLVAKDILKPHAVFWPTMLMSAGVDLYQGLRVHGYWTVQEAKMSKSLGNVVQPMDMVDKYGLAPFRYFLLREMQFGLDASFSEEALVNRLNSDLANDLGNLCSRTLAMTNKYFQGLVPEKSGLSQEDQEVVDAGLTALDEYVRLFGDFQFSKGLSVLWAFIGRLNKYVDASAPWVLYKEGQTERLQNVMYVLLEGLRKIALHLWPVMPSSSEELLSQLGTGFDLHKVDLEQEAGHWSGLKPGVRVAKKSNLFPRRELELKQETGKEKKDGAKAAESPQTSQVSFEDFLKLNMVTGRVLQADKVQGADKLLKLEVDIGEKKPRLIVAGLAQHFEPGDMQGRQVVVLANLAPKKIRGVTSHGMVLAVRHGQDMVLLTTTEGTEPGSRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP00</accession>
    <name>D6SP00_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase, P-type (Transporting), HAD superfamily, subfamily IC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869798.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1835"/>
    <dbReference type="EnsemblBacteria" id="EFI34476">
        <property type="protein sequence ID" value="EFI34476"/>
        <property type="gene ID" value="Dthio_PD1835"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cation_ATPase_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="923" mass="99692" checksum="AB6248ADE4580518" modified="2010-08-10" version="1">MKTDPDIEPETSWHSMPVQEVFQHLQTSENGLDSSQARQRLDSFGPNKLPRARKQGPFKRFLLQFHNVLIYVLLAATIVTALLQQWVDSAVIFAVCLVNALIGFIQEGKAEKSMESLQGMLAPVATVLRDGQKKTVPAEELVPGDVVVLSSGDKVPADLRLFQARDLQIEEAALTGESVPVGKDIYEADPEAGLGDRSCMAFSGTMVAYGQGAGVVAATGAHTQIGRISAMLAQVQTLTTPLLKKITRFGHFLTAAILVTALATFAFGILVRQLMPSEMFMAAVGLAVSAIPAGLPAIMTITLAIGVQRMARRNAIIRKLPALETLGAVTTICSDKTGTLTKNQMTVQSVQVSEDLYLITGTGYNPMGEFRLQDQNIDPLQHSLLAETLRAVLLCNEAHIYYQENEGVYRLEGASTEGALVAAAMKAGLDQKQENADRPRIDAIPFSSDKKFMATLHDYHQDGGRRIILKGAPERVLERCSHQANSNGQKELDPDFWHNSGETIASRGQRLLAVAFKDVPGDKKGLDEEDTSEGFTLLGLFGIIDPPREEAVKAAAKLIGRCVSVRDCQSAGINVKMITGDHALTAVSIADELGIGDGRTFLAGKDLEKMSDEELEKKVPGVDVYARTSPEHKLRLVQALQAGGNIVAMTGDGVNDAPALKRADVGVAMGKGGTEAAREASDVVLADDNFASIANAVEEGRTIYDNLKKAILFILPTNGGQALVVMASIVLGIGLLGEGGEYTLPISPPQILWINMIIAVTLALALAFEPPEGNVMSRPPRPPDEPLISGFLIWRVASVSVLLVIGTLWHYQYMLSGGASHELASTTAINTLVVGQVFYLINSRFIHEPAWSIRGFLGSRAVLISIAVLAVLQIGFTYLPFMQYIFQTEPVCLESWIRIVLFGIIVFLAVELEKAFFRSRTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP15</accession>
    <name>D6SP15_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869813.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1850"/>
    <dbReference type="EnsemblBacteria" id="EFI34491">
        <property type="protein sequence ID" value="EFI34491"/>
        <property type="gene ID" value="Dthio_PD1850"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="26320" checksum="33DF305D75B1CE33" modified="2010-08-10" version="1">MDNSPPSDKAVFEIRGLSKTYRMGEVIIHALRGVDLDLYQGELAVLLGASGSGKSTLLNILGGLDSAGDGEIRYQGRSLTHAGERALTDYRRNHAGFVFQFYNLISSLTARENVAIVTEISRDPMTPEEALELVGLGKRMDHFPAQLSGGEQQRVAIARAVAKRPFVLLCDEPTGALDSKTGVRVLEVIEHINATLGTTTVVITHNEVIGRMAHRVIRISDGRIAYVQPNSHRLPPGELKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP27</accession>
    <name>D6SP27_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="9">1.2.7.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869825.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1862"/>
    <dbReference type="EnsemblBacteria" id="EFI34503">
        <property type="protein sequence ID" value="EFI34503"/>
        <property type="gene ID" value="Dthio_PD1862"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332680at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="625" mass="67788" checksum="526FB786D2BB7316" modified="2010-08-10" version="1">MPFGYNGKILVVDLTNQTWSVDERDEAWYRTYWGGGSLASWYMLKEIPPKADPLGPDNVLVFAASVLCGSGISGFNRYTVAAMNPLTGGFGESEAAGYLGPALKHAGFDAVVLKGKSPQPVYLWINNGQVELRDAAHIWGKENAPTLDTIKNELGEKKIRIASIGPAGENMVRLACIINELAHANGRCGMGAVMGSKNLKAVAVRGDSANMSLADPDKLDEISKWHRKRIAEHMPSINMRKFGTVQHLMAQQNSGILPTRNWRDCQFEDASSLGWEGYEKVSKGTHTCYKCAVACKRRVNNTEEKRYGGPEYETLAALGSMCGVGDLNAVCKGHERCNALGLDTVGTGAVVSFAMELAEKGILSAGDLGGTELKFDDAQGMLDLIEKIGAREGIGDILSQGVKRAAAAIGRGAEEYAFHVKGQEPAFHDPRGKTGVGLGFALSPTGADHIEAPHEVPFQGEGVKLVNPLGIFVAPQALDTGPEKVRYFIAGEKTWAMNNTLGLCNFVVAPLFSMTYDKLCEAVEAITGWQTSVHELMLVAERSIVLARMFNVRQGMDSKDDKLFRRMFEPLPDGVLKGEAISPDSFQQAVDLYYAMMGWDEKGVPSKGTLYRLSLDWLANGGMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPB4</accession>
    <name>D6SPB4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC C subunit domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1962"/>
    <dbReference type="EnsemblBacteria" id="EFI34590">
        <property type="protein sequence ID" value="EFI34590"/>
        <property type="gene ID" value="Dthio_PD1962"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10915" checksum="7BF11F2F64F58E8F" modified="2010-08-10" version="1">MPYFVYILQSSSTGRYYCGQTDDLTKRLAQHNDPSQMLTLTTKRHRGPWDLIWSQELETRQEALRLERRIKKRGIGRYLADTGKSQFQHRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPF0</accession>
    <name>D6SPF0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869946.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1998"/>
    <dbReference type="EnsemblBacteria" id="EFI34626">
        <property type="protein sequence ID" value="EFI34626"/>
        <property type="gene ID" value="Dthio_PD1998"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="323" mass="36111" checksum="0F43A1769AC61670" modified="2010-08-10" version="1">MLFFIIRRFVTMIPLLLGISVLVFVLMAIAPGDFLDVARTQEDIPAEYIERMEEEFALGEPWHTRYFIWLGNVVQGNLGESWIYRVPVTELLWQRIPATLVLSALSIMFALCVAIPMGVLAAIYKDSIFDRVSSMFAYAALSIPEFFLALLAVMFAAQTGWFPTGGLSSVEHEFMSFWGRMADYAHHLVLPTIVLGMGSVASYMRIMRANFLDYIRSDFVTTARAKGLGEGRVMFVHVLRNAINPLVSASGFILATLLSGSILVENVMNYPGLGQLIFEALMRQDEFVVVAAVMMGCVMLMLGNLIADLLLAWSDPRIRLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPI0</accession>
    <name>D6SPI0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869976.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2028"/>
    <dbReference type="EnsemblBacteria" id="EFI34656">
        <property type="protein sequence ID" value="EFI34656"/>
        <property type="gene ID" value="Dthio_PD2028"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="182"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="249"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="522" mass="56623" checksum="666ED51998AC406F" modified="2010-08-10" version="1">MQRLLGSLESFRTAVLALVAVYAALMVLMVYFRAPEGLLLAAICAGGALIILAVITFTSLVSRTLQDNITQAKSIASGHYTSTFRQLPDQGLMGQSQEALREMLEHLKYELSLSRGIMHSMATPCAVTDTEENFIFGNQKLVDMLEHEGRPEDFYGQNVAVFFYGEKRQTVLGTAMQENRWISKEVEFTGRKGGKRSIHIDASPLYDIEGKLMGSLCIYTDLSEIRASEARIKEQNRIISSYASQATSISESLASSSRDLAAQVEQASRGAESQTSLAGQTATSMEEMNSTVMEVARNASAAAQEADQARDMAREGSKVVEDSVAAINKVHGKSRELQSSMDSLGKQAQEIGNIMNVIDDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMKATREVGQAVSSIQEGANSNIQGMDQASALIDEANSLANRSGEALEDIVRRVQKATEQVQAIATATEEQSTASEEVNRNIEEVNRISRETSEVMTQSSGSIAELSRQAQELKDLVQQLSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPJ5</accession>
    <name>D6SPJ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma54 specific transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD2043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869991.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2043"/>
    <dbReference type="EnsemblBacteria" id="EFI34671">
        <property type="protein sequence ID" value="EFI34671"/>
        <property type="gene ID" value="Dthio_PD2043"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="8"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="340" mass="38201" checksum="F21EF548D45111E6" modified="2010-08-10" version="1">MSVDTSDIIGKSRVLRDVFNMLAKVAPTETTVLVAGESGTGKELLVRALHRNSQRRDKPMVPVNCGAIPKELLESELFGHEKGAFTHAVRSRAGRFEMAEGGTLFLDEIGELDMSLQVKILRFLQEKEFERVGGSKSIKADVRVIAATNRNLEEEVKSGCFREDLFYRLNVIPIELPPLRRRGDDVLLLAEHFLDKYSRGSKPLGISSGARDLLLNYPWPGNVRELENFMERMSILCDNNEIKPADLPEKVLQAGGIEPEFRPDQGDGFKWPSLKDMQESGLDLKDFLENIEDRLLLEALENSEWVKNQAAEVLGIKRTTLIEKLKKKDLAPGSSTQIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPL2</accession>
    <name>D6SPL2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2060"/>
    <dbReference type="EnsemblBacteria" id="EFI34688">
        <property type="protein sequence ID" value="EFI34688"/>
        <property type="gene ID" value="Dthio_PD2060"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SWZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="168" mass="19712" checksum="E00EE4D75313027E" modified="2010-08-10" version="1">MPRYILLLCIIMMLAGCSYMSVKHLSSNPLSFDQEEELQMRYWDFAYVNKVKNDHYHIQGTAYPRQENLPGWGKWMHNLWITAYLSDDDGRVLARDLRVYPTQELDPQNGVPMDFRLKPDKMPGSEDIYITFGYRMQLTEDRYVDPSSQRPLTGEKSVFFASEKALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPM0</accession>
    <name>D6SPM0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870016.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2068"/>
    <dbReference type="EnsemblBacteria" id="EFI34696">
        <property type="protein sequence ID" value="EFI34696"/>
        <property type="gene ID" value="Dthio_PD2068"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2107284at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="359" mass="39963" checksum="40602B265B3C9D7D" modified="2010-08-10" version="1">MHFRLKIFTATLAILLFTLVLNSVLSISSFEKIYSRSLVSIMESRAVNLKQDIERGILLGKPLDAFEGMDDMLAQFLDSNPRVENVAVSMEPGEIIYFKGAEENGSSLLARHAQEFEGQEEPHAVFDRDRYILYLPIVHRAEQQTHGGLFLSFSQAVILERITQMIKGALNRLGWSLGGTALVLVGLLGLFVVRPIRKDLERIRQALLPFTREHKTAGTQDVPHEEADSRLSPVSKDAKTHKAGPAAPGSGRTPLTQKFPDSRIIRNDILSLGSYLQEIALELESRGKEAAEFPGRSLKEIAHGLEMCTKELAEHLENEEIPHDLRLELEQIIRDSRQAVQALGRATDDVTIQGVLGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPS7</accession>
    <name>D6SPS7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2129"/>
    <dbReference type="EnsemblBacteria" id="EFI34753">
        <property type="protein sequence ID" value="EFI34753"/>
        <property type="gene ID" value="Dthio_PD2129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="473" mass="54344" checksum="18E03E25055A035B" modified="2010-08-10" version="1">MSEIYNMIKDCRLYRNKVQINSQEYVNSRSVVNYNKNDQDINYDIKDILFLCALSGTDCLMTGKTGAGKTHLSSLAMQALFGDEHRENKTEIDDNNESRYMEGYVNKTITPSMRPQEFLDISYKLFIESGESLKGAMEKTPILQVPGVILNEANRAPGFVQNFLIPFLDKKMDIEGKYVDVGVDNGVQNYQFRTITINEGEEYETTAMDKALRDRVGLEIPMDGFYQSSSDCLEMLKKMAKSKSDKDNDVNLEEPSMSMPELSGKIEGLVKKNREVSFLLLYLSGMSYCYKVAQYNVWPPVKELIQLNEAFCSDCRYAAATELNSEHNICGSVRALSQRALRQLLRLSQAVCVGAMIQESRLNKTSEFVVQEEDVWAIAPLVLYKKLQLSQRWLNAHAGSEWIALLSAIELIRKRWEKIKEKNILEHAMKADEGQALNEKVMREIRDYVSRQTDYWVLRLFPTYRAETLRIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPZ4</accession>
    <name>D6SPZ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870134.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2207"/>
    <dbReference type="EnsemblBacteria" id="EFI34820">
        <property type="protein sequence ID" value="EFI34820"/>
        <property type="gene ID" value="Dthio_PD2207"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1812319at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="344" mass="39171" checksum="4F27ED91EBE2242C" modified="2010-08-10" version="1">MIEHVQGNILNAQTEALVNTVNCVGVMGKGIALQFKKAFPENFKTYRNACQRGEVKPGRMFVFDTGQELPRYIINFPTKRHWRDKSRYEDIEAGLQALVKEITARNISSIAVPPLGSGLGGLDWAKIKPMIERAFSDLPNVQIQLFKPEGSPQASEMPVGSDRPHLTTARALFIKLMQQYKRFAYRLTLLEIQKLAYLLQESGLNLRLSYVRHYYGPYAHNLNKVLEILEGHYISGYGDTQKPDVEIKLLPDAIDAADVLLSKHLEAYKHLNRVADLVDGFETPYGMEMLSSVHWLAVHERLAVDQQSAISAMAGWNERKKCLFKPEHICIAWDRLQEEGWITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ62</accession>
    <name>D6SQ62_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870202.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2279"/>
    <dbReference type="EnsemblBacteria" id="EFI34888">
        <property type="protein sequence ID" value="EFI34888"/>
        <property type="gene ID" value="Dthio_PD2279"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="148"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="458" mass="50246" checksum="27DB0F5CB69491DC" modified="2010-08-10" version="1">MENEKDKPALLVVDDESGHRMMVKAVMQDQGFKVMEAGNGLQCLDMLEQQHIDVVLLDIKMPGMDGMQVLERIHRLHPGVQVVMLTAFGSVGSAVDAMKQGAFDYLTKPADIDELKSVIQMALDYSRLVRDSARTGKGLQGVQEKARVIGQSPAMHRVMDLVQQVGPSEASVLILGESGTGKELVARALHQAGPRSQGPLVSINCAALPPELLESELFGYKKGAFTGAAKDKPGKFQLAEKGTLFLDEIGEFPLQLQAKLLRALQEKVVQPLGGTQEDPVDVRFVAATNKDLLQEVRQGNFRQDLYYRLNVVEITVPPLRERMEDLPFLVNHFVEVLGEKNRKQVRGINNNFLQALKSYHWPGNVRELENVVERAIILCRSDVLDAGDLPESIAGGGTTGNFAGNAPGKEGLESAEKAALQQALKANNGHRENTAQALGISRRSLQYKLKKYGLTRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ74</accession>
    <name>D6SQ74_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870214.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2291"/>
    <dbReference type="EnsemblBacteria" id="EFI34900">
        <property type="protein sequence ID" value="EFI34900"/>
        <property type="gene ID" value="Dthio_PD2291"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="191" mass="21507" checksum="E27D2B90489D7C67" modified="2010-08-10" version="1">MKSLKGTKTEKNILTAFAGESQARNRYTYFAKQAKKDGYVQISNIFEETANHEKEHAKRLFKFLEGGEVEIQAAYPAGKIGSTVENLKEAAAGENHEHQSMYPEFAKTAREEGFEEVAVAMEAIAVSEQFHENRYRTLIANIEQGKVFKKDQEVTWKCQNCGYTHKSAEAPGECPSCAHPQAHFEVLCEHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQA7</accession>
    <name>D6SQA7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2325"/>
    <dbReference type="EnsemblBacteria" id="EFI34933">
        <property type="protein sequence ID" value="EFI34933"/>
        <property type="gene ID" value="Dthio_PD2325"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50334IY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2048823at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="136" mass="15563" checksum="8E846445D0004685" modified="2010-08-10" version="1">MEENNENVKVTDRRINYDQDSAEQQGAAQESEARKMERKKAAQDYKDAAADKENAYPRLDFSTFVFSLSSSALAHLGEMPNPENGQHEVNLPLAKQTIDILAMLEEKTRGNLTHAEEQQLKDFLFEVRMKYVQKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQC9</accession>
    <name>D6SQC9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MotA/TolQ/ExbB proton channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870269.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2347"/>
    <dbReference type="EnsemblBacteria" id="EFI34955">
        <property type="protein sequence ID" value="EFI34955"/>
        <property type="gene ID" value="Dthio_PD2347"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="897037at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MotA_ExbB" evidence="7">
        <location>
            <begin position="100"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="252" mass="27415" checksum="A5BFAC2B5EA60AEE" modified="2010-08-10" version="1">MDFATFFGIIVGFSLIIGAIFIGGAVDTFVNVPGVMIVLGGTMAATSINFPVTDINKAFRAAFYIFAGKSVTANDVVNTMVRIAEISRRDGLLALENIKTENSTLKKACQLIADNTDPETISQTLRIEIVALRNRHAVIQDVFKKMGTYAPSFGMIGTLIGLVQMLTMLDDPASIGPAMAVAILTTFYGALLATLLFLPIAGKLKSRTQQENLHLEIIFQGAQSILENNNPRVVYEKLSSFVPPAERKNERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQE1</accession>
    <name>D6SQE1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2359"/>
    <dbReference type="EnsemblBacteria" id="EFI34967">
        <property type="protein sequence ID" value="EFI34967"/>
        <property type="gene ID" value="Dthio_PD2359"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="71"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="344" mass="38434" checksum="EDA125EA607B7636" modified="2010-08-10" version="1">MMHTSKQAILWKPLKEQKVQCLACCQFCLIEDGGRGFCGVRQNTRGELFTLVGDNVAAMNVDPVEKKPLFHFMPGSMTLSLGTMGCNFSCSFCQNYTLSQPPKEHQFRQGQPVTPEQLVSTAREYRAGSISYTYSEPTVFIELVLETARLARENKLKNIIVSNGFQSPDCLKEMDGLIDAANIDLKAYTEDFYQNQCKSRLKPVLDNLVKIREMGWWLEVTTLIIPGLNDSTRELKDMAGFIKNNLGAHTPWHISRFHPTFNLTDRQSTPVETIEEAWHTGKEAGLEYVYTGNIPGHDGENTTCPGCGEIVVSRLGFQLRSVNLDKGACAGCGRKIAGYKMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQE6</accession>
    <name>D6SQE6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component, sigma54 specific, transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2364</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870286.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2364"/>
    <dbReference type="EnsemblBacteria" id="EFI34972">
        <property type="protein sequence ID" value="EFI34972"/>
        <property type="gene ID" value="Dthio_PD2364"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="144"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="449" mass="51262" checksum="BE5E5692B12077AF" modified="2010-08-10" version="1">MTKQYSVLVVDDEQSILTLFKKEFATPERSISTASSASQARQLIRKNVFDVVLLDICLPDGDGLDLYTEFKERMQDVEIILITGHGNIDNAVRAMKLGAYDYITKPFNLDKLELVIERAWQRACMQRENRSYRLYSGNNRTHRMVGASESIKHIRYLVDKVAPAEVPVLLTGESGVGKDVAAQAIHHGSQRADKPYIVKNCASLVKELARTELFGHVKGSFTGATESSDGLMAYAHKGTLFLDEIGELPLEVQASLLRVLENRTYRRVGEKEERSIDVRFIFATSRNLYTEVEEGRFQEALLHRINVFNIETPPLRDRLEDIPLLVEHFLSSLNTSITDYRVTDKAMNCLMNYSWPGNVRELRNVLERSMILAEQGNITERSLPRELVEKTLDAHEQGRQEGIFSLRLAEKNHISRVLSYFQGNRQQASKAMGIGRKTLYRKMKEYQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQG8</accession>
    <name>D6SQG8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">Dthio_PD2386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870308.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2386"/>
    <dbReference type="EnsemblBacteria" id="EFI34994">
        <property type="protein sequence ID" value="EFI34994"/>
        <property type="gene ID" value="Dthio_PD2386"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200722at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="160"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="275"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="402" mass="43508" checksum="CBC155911E65AEE8" modified="2010-08-10" version="1">MQYISDLDLQSRPDQPRHLAIMGSTGSIGTSALKVIRQHPEKFRIIALAGARNIELLAEQANEFRPQYLGVLEKDLASGLKKKLASGYSPEILAGTEGYTRLASLQNVQMVLSAMVGAAGLMPTLEAVDKGKTVLLANKESLVLAGHLIRAGCERTRAVILPVDSEHNALFQALQGHGAGELDSVIITASGGPFWGRKASSLEDMKPEQALAHPNWSMGAKISIDSATMMNKGLELIEAHHLFGMPMDKVRVLVHPQSIVHALVQFCDGSILAHMGVPDMQMPIAHCLGYPRRLDPGLEPLDLAACTELGFYRPDPGAFPCLELAVEAMKSGPSYPVVLNAANEICVESFLTGRIGFMDIPRINSRALEEHCPTAVDSPREILNLDHQTRQRVSELVLQPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQQ1</accession>
    <name>D6SQQ1_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Lon protease</fullName>
            <ecNumber evidence="6 7">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lon</name>
        <name evidence="15" type="ORF">Dthio_PD2471</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7 10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="6 7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870391.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2471"/>
    <dbReference type="MEROPS" id="S16.001"/>
    <dbReference type="EnsemblBacteria" id="EFI35077">
        <property type="protein sequence ID" value="EFI35077"/>
        <property type="gene ID" value="Dthio_PD2471"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="39"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="622"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFI35077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="805" mass="90186" checksum="42CC506AC7978349" modified="2010-08-10" version="1">MSDDKIFFAEPGEIVNPAEDNPKSESSGQESELEIPSSLPLLPVRDIVVFNYMILPLFVGRDKSIQAIDHALNNNRYLLISTQKDEQVENPGPDDLYQTGTVVMIMRMLKMPDGRLKVLVQGINKARIRRFVQTDPMDIVEIDVIKDKEFTDPTSESEALLRAAREQSEKLLGLRGVDASEIMAVLNSVDDPGRLADLVASNLRMKPADAQQILECDDPLQRLKMVNEQLVREVEVASMQAKIQNMAKEGMDKAQREYFLREQLKAIRKELGDVTESGDDLEQLRESLKKARLPAKVMKEAEKQLQRLENMHPDSAESTVARTYLEWLVEIPWKKKTKDRLDIKEAQKILNDDHYDLEKVKERILEYLSVRKLNPRMKGPILCFVGPPGVGKTSLGQSIARSLNRKFVRMSLGGMRDEAEIRGHRRTYIGSMPGRIIQSMKEAGSVNPVFMLDEIDKVGADFRGDPSSALLEVLDPEQNHSFTDHYLNVPYDLSKVMFICTSNILDTIPSALLDRMEVIRIPGYTEQEKVHIARKYLLPRQIKESGLKEKDISLSDGVLKEIIRNYTREAGLRNLEREIGAVCRKIARQVAEGKKGPFRITRKKVDKLLGVPKYMPEDREKELPAGVAIGLAWTAYGGEILHVEVSLMPGKGKLILTGQMGEVMKESAQAALSYARSRAKTLGLDEDLLDKRDIHIHVPAGATPKDGPSAGLTMVSALVSALLDRPLPGDIGMTGEITLRGRVLPVGGIKEKILAAVASGVKTVIIPDSNKRDFNEIPPELRKTIQVKTVENMDQIWPILDIARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQQ3</accession>
    <name>D6SQQ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2473"/>
    <dbReference type="EnsemblBacteria" id="EFI35079">
        <property type="protein sequence ID" value="EFI35079"/>
        <property type="gene ID" value="Dthio_PD2473"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="116"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="238" mass="27193" checksum="38858BD87A0ADD7E" modified="2010-08-10" version="1">MISPLGMEKRAIMDSQKPHYTGHRQRLKKRLDNDPSSLQDYEILELVLGYALPRKDTKPLAKALLNRYPTFKDLLAARPGDLQAIDGIGPGIITFFRLWGEFWARTDRSGLSTRSTLDSPEKVARLARSRLQFKSIEEFWAIMVDNKNRLIDFEKMSRGTVDQAPVFPREILTVALEKRASGVILLHNHPGGDPHPSFQDRELTRKIREVSTALGVRLLDHVIISEDSFFSFQEHGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQR6</accession>
    <name>D6SQR6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Acyl carrier protein</fullName>
            <shortName evidence="8">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acpP</name>
        <name evidence="12" type="ORF">Dthio_PD2486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870406.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2486"/>
    <dbReference type="EnsemblBacteria" id="EFI35092">
        <property type="protein sequence ID" value="EFI35092"/>
        <property type="gene ID" value="Dthio_PD2486"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="UniPathway" id="UPA00360"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036104">
        <property type="term" value="P:Kdo2-lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 8 9" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8 9">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="76" mass="8514" checksum="419027136ED2F665" modified="2010-08-10" version="1">MSVEQKVKDIVVDQLGISAEEVKPEAKFVEDLGADSLDLTELIMAMEEEFDIEIDDEKAQELLTVQSAIEFIKANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQW0</accession>
    <name>D6SQW0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870450.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2531"/>
    <dbReference type="EnsemblBacteria" id="EFI35136">
        <property type="protein sequence ID" value="EFI35136"/>
        <property type="gene ID" value="Dthio_PD2531"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="568" mass="65423" checksum="242BD882DD88AB35" modified="2010-08-10" version="1">MGKKILVIMIAAVVLGCAPKTQQPETAKTGRELTPQAQVTYHYLKSLDYQAAGDHEKAALALEKALVLGPSVRLYQDLAREYLRQGEKQKAVDILQDATGIYPRTPELYFQMAEFYLVKGDRSGAVKALEKYKDLVPEDLDVYEDLAAFYIEMRDYAGAVDLLQEIPPDEMTPEMHYYMGRAKSELGEKTDAVAYLDKAVQARPGFMQAWAEKAFIYEQERDYLQAERIYQQLLKMGERSPDLILRIVELNLLLNDPERAVAMFGKGPDEVRFQLDMVNQFIRNEFYEHADILLQDIAAESDYPDTMYFYFALIAYEGRNDPQLALDYLSRISKEDSYHLQALSFRVQILFHEKNYQEALELSRKGQELHPGEDRVHLFEAIVLEAMEEYQEARKVLEKALEKWPGQTDFLFRKGVVLDKSGKTEKSLQIMEEIIALDQEHHEALNYVGYTLADQDRDLDRAMILIKRALELDPGNGYYIDSLAWVYYRQGSYEKAWEEILAAVEQVDDEAVIWEHYGDIAKALGKREHALHGYEKALELDPENPEHLREQRAKVKDMPENESAKAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQZ5</accession>
    <name>D6SQZ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor synthesis domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870485.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2569"/>
    <dbReference type="EnsemblBacteria" id="EFI35171">
        <property type="protein sequence ID" value="EFI35171"/>
        <property type="gene ID" value="Dthio_PD2569"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="98"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="257" mass="27207" checksum="136F094A81EFD51C" modified="2010-08-10" version="1">MLVIQGKGKIAAGKTLVLGPPGAVGVRGTYTGDDPVLRALRAGVFLQRDIPVFQVLDKPWINGDGETGFLGIVLQALADVDLEESPELRVKCRGRSLAWITLSDKGARGERTDTSGPMIRETAEKGLSLTLCRGWVIPDDAYLLRSLLQHLAFNSGFDLIVTTGGTGLGPRDITPEVTGHAVEKRLPGFEQAMMAASLQKTPHAAISRAVAGTLDQSIILNLPGSPRGVKENLEAVLPAMEHALAKLQGDVADCAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQZ6</accession>
    <name>D6SQZ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UvrD/REP helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870486.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2570"/>
    <dbReference type="EnsemblBacteria" id="EFI35172">
        <property type="protein sequence ID" value="EFI35172"/>
        <property type="gene ID" value="Dthio_PD2570"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="2">
        <location>
            <begin position="462"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="3">
        <location>
            <begin position="701"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="483"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1027" mass="116128" checksum="AB939162ED621357" modified="2010-08-10" version="1">MDTFLADLHIHSCYSRATSKSLDPPSLAAWAAAKGIHVVGTGDFTHPGWVQMLREHLVQGEDGLLCLREKSDLSSYIPGFEQRLEAKTRFMLSAEISSIYKQGGRVRKIHNLVFFPGFEQAEKFNSKLERIGNLKADGRPILGLDSRSLLEMVLDTDPWGFVIPAHIWTPWFSLFGSKSGFDSLEECFGDLAGYIFALETGLSSDPEMNWMWSKLDRFAMVSNSDAHSAENLGREVNLFQGEMSYEGMFRALRREGLGNRFLGTLEFYPEEGKYHLDGHRKCGVVMDPRQTMAHRGKCPVCGKDITVGVLNRVMAMADREEPSRPDYQPGFSSVIPLKEIISEILGVGPKTKKVQSFYNSLVHRFGPELQILQNVPVEDLGRFNSPLGKGIARMRTGEVIRQPGYDGEYGVVRVFTDTERQEFKKGKRLMPVAEDNRKQEYKRIKSVQEDPESAARVQEKHLEFNAAQQQAIEAGPEPVLVMAGPGTGKTQTLMGKVSRLLEQEVNPRHILVLTFTRKAARELKDRLISIHGDDQALPRAETMHAMAFEHWKRVYGEEPLILGEEEAFKVFAESSPDLKGSALKKAWQETGAAREQLLALPAAGENYNRQKQDWNQVDYADLLEFWLQELQSGKFVRPYTHVLVDEIQDLSRLQLEIIRELLPEKGEGFFGIGDPRQSIYGFRGAVGDVPQVLRSFWPDLQVVSLKENYRSSRGILELSQGLFPEDASLEAKVALPAGMTLYRAAEGVQEAHWVGQRISELLGGTGHWQMDGQTEPSGLAPEDIAILVRFKALGTVLEKELHRMGIPVCVPQQEPFYQDHRVELILKAASRVLGVSWSQEVFECPEKVLAKGPLGLAAYLGDVPPFDRFFWQSRAFRELEKQYREKGGWAGLINHIRLESELDQAEMKSRKVKILTMHAAKGLEFEAVFLPCLEDGIVPFAGMDFLLGKPAQAEHKSDELEERRLFYVALTRARRHLYLSLAGSRKVYGRLLRLKESRFLSMLDLTGVHKTRARICKTKREKRPRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR49</accession>
    <name>D6SR49_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870523.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0488"/>
    <dbReference type="EnsemblBacteria" id="EFI33165">
        <property type="protein sequence ID" value="EFI33165"/>
        <property type="gene ID" value="Dthio_PD0488"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="304" mass="35247" checksum="039B961E4BDC6CA9" modified="2010-08-10" version="1">MPRIARFIRDNQPSVYHVISRTALQGLPIKDKDNDFLLGLIKKLSQLYFVDVLGFALLGNHFHLVIRMYPESDPTDDEIKERLQKYYGDELNVTGVLISDYRKRLTNLGAYVKDIKQGFTRYFNKKYGRRGFFWGDRFKSMIVQDGLSLVNLLAYVDLNPIRAGIVKKPEDYRWCSLGYHTQTGNKGGLLSMDFGMKEWNEFDPKEIVRKYRQFVYETGAVDAGKGKVMDKKIVEKARKKGYKISRTDRFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDTRKFTPVGGVEGTYSMKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR77</accession>
    <name>D6SR77_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870551.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0519"/>
    <dbReference type="EnsemblBacteria" id="EFI33193">
        <property type="protein sequence ID" value="EFI33193"/>
        <property type="gene ID" value="Dthio_PD0519"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032VNR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1807838at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="138" mass="16224" checksum="4F381FD6992FB833" modified="2010-08-10" version="1">MTINQSLVKNMFQNYDRQLVNGRKLSRLSRYLRDPQGEDPHSTSREKKRRAMVERVAREIVENLITADTQNQIVKEIKAELRRETDEDLIFHYPPTGEDMKVLKPGADGPEELSMQEKDIILRKLWEITLDKVNETML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRE5</accession>
    <name>D6SRE5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Silent information regulator protein Sir2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870619.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0587"/>
    <dbReference type="EnsemblBacteria" id="EFI33261">
        <property type="protein sequence ID" value="EFI33261"/>
        <property type="gene ID" value="Dthio_PD0587"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="249" mass="27280" checksum="0FFF377867D56368" modified="2010-08-10" version="1">MSNSEKLYQEAAGAIRSSECMLALTGAGISVASGIPDFRSPGGLWSRYDPQAVASDWALENNPRQVWEFLLEAVGMIAAAKPNPAHESLARMEDMGYLKAVITQNIDNLHQRAGSRKVIEFHGGAGTFYCHKCKKKYNQQKALELTRKDIPWLCSQCYGVVRPGVVFFGEQIPEQALQETRRLVLAADLVLVAGTSGDVAPAGTLPRWVKEQGGRVIEVNLGRTSFQNISDIRLDEPAETALPRIVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRI4</accession>
    <name>D6SRI4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870658.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0626"/>
    <dbReference type="EnsemblBacteria" id="EFI33300">
        <property type="protein sequence ID" value="EFI33300"/>
        <property type="gene ID" value="Dthio_PD0626"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088278" evidence="1">
        <location>
            <begin position="22"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="179"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="279" mass="31137" checksum="0BAC3A596C2F41A6" modified="2010-08-10" version="1">MIRKILFSLLLIFFWAMPVYALDVQVPSEVGRGEPFWVDISSDDKPAGIKVAWMDREFAVPVDLPGEQRVLLGAGLDKTGEHELSLVFDLDGESLEKTFKISVKDKDYPEQHLSLPEEMVTPPQEVHDRIARDREQIRSALSTLTMDRYWEEDFKEPVPGDVSSPFGVQRFLNGQPRSAHQGVDFRGPEGTPVKAVTDGRVVLTGDFYYGGKTVILDHGQGIHSLYMHLSSIDVQEDVFVSQGEKVGEVGMTGRATGPHLHLGVYVLGDAVDPMYLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRT4</accession>
    <name>D6SRT4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870757.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33400">
        <property type="protein sequence ID" value="EFI33400"/>
        <property type="gene ID" value="Dthio_PD0731"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="63" mass="7080" checksum="2A0D2A629C6B9251" modified="2010-08-10" version="1">MKRCFIDSNIVVYANDTRAKSRQSRAIETISACMRAGKVTENMGTLCCEFTRLNIYPVKSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRV0</accession>
    <name>D6SRV0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33416">
        <property type="protein sequence ID" value="EFI33416"/>
        <property type="gene ID" value="Dthio_PD0748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="43" mass="4704" checksum="A96F77A28CD4AA43" modified="2010-08-10" version="1">MNGKNSCGVKKKSGISAEYWSLTTEHSGNYLKGGVCGVYVYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS07</accession>
    <name>D6SS07_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0807"/>
    <dbReference type="EnsemblBacteria" id="EFI33473">
        <property type="protein sequence ID" value="EFI33473"/>
        <property type="gene ID" value="Dthio_PD0807"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="148" mass="15746" checksum="748B2115F0930B31" modified="2010-08-10" version="1">MNSKEPVSAEGLMPHERPMRLVDTVLCSGDDGSGEAAARIHDGNIFVDQNGLLAREALAELMAQAFAAINGKTAVQSGGRGVKGYLVGIKQMHFWGEARAGDYLTISIRPAGDFAGFVLLTGEVRCQNKLLASGELKIWLASQESGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS90</accession>
    <name>D6SS90_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870906.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0890"/>
    <dbReference type="EnsemblBacteria" id="EFI33556">
        <property type="protein sequence ID" value="EFI33556"/>
        <property type="gene ID" value="Dthio_PD0890"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935911at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="117" mass="13613" checksum="E3DC480AABC69908" modified="2010-08-10" version="1">MQALTKTHPTEAIELRITGPRDKKDEVLREIKKHGYTDSSDSIPWRELFQEFENEPEYSVALRGARNREGLTQTELSRLTGIPQGHISKMENGRMEIGKERARRLAEVLNMDYRVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSB8</accession>
    <name>D6SSB8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870934.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0919"/>
    <dbReference type="EnsemblBacteria" id="EFI33584">
        <property type="protein sequence ID" value="EFI33584"/>
        <property type="gene ID" value="Dthio_PD0919"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="137" mass="15490" checksum="7C4778FCB2E31641" modified="2010-08-10" version="1">MQDCIFCKIVRGEIPSAKVYENDSVLCFLDVAPAVRGHSLVIPREHVENILEIPEDMAAHLHEAIRRVGRGIIQGLKADGFNVGMNNFQAAGQVVMHAHWHLIPRFHGDGLQLWPQYKYDNNEEMQDFARKISSAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSF5</accession>
    <name>D6SSF5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PTS IIA-like nitrogen-regulatory protein PtsN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870971.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0956"/>
    <dbReference type="EnsemblBacteria" id="EFI33621">
        <property type="protein sequence ID" value="EFI33621"/>
        <property type="gene ID" value="Dthio_PD0956"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1810962at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="149" mass="16430" checksum="7135D45E9D04BCF1" modified="2010-08-10" version="1">MHLADFLSPDQIVAGLVSRNKTEVLDELAAPLVEKHDFLDRNEVNNVLVSRENLGTTGIGDGVAIPHGKIAGLDNILISAGLSREGVDFSALDHKPVHIFFLVLAPEKSAGKHLKILAFISRLLQDPDFKDCFINAQSREELWKLINRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSH0</accession>
    <name>D6SSH0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD0971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870985.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0971"/>
    <dbReference type="EnsemblBacteria" id="EFI33636">
        <property type="protein sequence ID" value="EFI33636"/>
        <property type="gene ID" value="Dthio_PD0971"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018771">
        <property type="entry name" value="PocR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10114">
        <property type="entry name" value="PocR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="171"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="240"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="296"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="369"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="422"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="493"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="691"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="943"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1150" mass="129603" checksum="1FEA59FCE45A6AD0" modified="2010-08-10" version="1">MSHKTFLFKDLVDLERLQGMFENYAASTGYKIGILSYPGQEMLISTGWKDLGSRFKSFQLVTGDSLNPGKHPYTADNARHRVCIRESPDGYLEGIAPVLVDGTLMASIFMSAPETSARPDGEDPDADESSPADDRSFQSALAFLSEMAAMLGDQGLAELRLRRTSRKLEKSEATFKSLVEHLPQRIFIKDLNSNYVTCNQIYAGDVGLTPEEIPGKTDFDLHPEELARKYRRDDHRVITQDAPLELEESYSRGDSSLWISTTKVPYRDESGNIIGVLGIFQDITRSKEQQAELKYKEQLLKNIVDTQSELICRFLPDGTLTYVNPAYCRYFNRDEQDLLGRVFLPMVHDDDLQYVQECFSSLGPDRPEITYQHRIRLPDGQIRWQEWTDRAFIDEQGKVFEYQAVGRDITEHRQAVNSLQESEQRYRGLVESQNDLIVRVDPDNRLTYVNDTYCKVFGRTREELLGSSFTPLVHEEDIEDTLKAMEDLKTPPYRAQMQQRAMTVDGWRWIHWEDSALLDQQGRIVEIQGVGRDITDLKKAQEDLQQSEKNFRLIFENSPVGMATHEILLDEHGRPVDYIFLDANPAFETHTGLSAQEVTGRRATEVLPGIENSSFIDTYAQVAFSGKTANFQEFSPPLNRHFMISAYQMAHGQFAASFIDITELEKTRRELVRAKEAAEAASQAKSTFLANMSHEIRTPMNAILGFAQILERDSTLGPDHARHVQSISRNADHLLSILNDILDMSRIEAGQIEHNPRDFNLHQTFEDLELMFIPRAVSKGLELTFEKNGSLPRAGHADPGMLRQIMVNLLGNACKFTSQGEVTFRISAEKNSEACGTGQGGFTLNVQVQDSGPGIDPEEMDRIFDPFHQGGRDPGEGGTGLGLHISRKYARIMGGDLSVSPHTEKGSLFCLQVPVQQATRPVEDGKPPSGRVQSLPADMAPVLVMVVDDKKDNRSMLVELLRPLGFETVEAADGREALDLFQERCPQAVLMDIRMPGMDGYQAIKSIRQVAGEQGPFIVAVTAFAFQQDREAALAAGADEYLSKPFQPEDLFRLLGQGLAIEYVMSDTRQDQPQGLYQEKMLPADLDPETISKMRSALEEGDVRLLKELISSIRKKHPQTSDTMMEMAERFDYIQLETMLDQARSGQNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSW4</accession>
    <name>D6SSW4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine pyrophosphate protein domain protein TPP-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871129.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1119"/>
    <dbReference type="EnsemblBacteria" id="EFI33780">
        <property type="protein sequence ID" value="EFI33780"/>
        <property type="gene ID" value="Dthio_PD1119"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="56"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="276" mass="30262" checksum="0A7C897BE6A5EBCA" modified="2010-08-10" version="1">MAKVTQLIHNYLRHSKRFPHVFCPGCGHGIVLGSLIRSIHSMGLAKDDVVLVAGIGCSGRIPVYVDFNTIHTTHGRALTFATGIKLANPRLKVIVIMGDGDALSIGGNHLIHAARRNIGVTALVLNNHIYGMTGGQSSCTTPMGSFSTTTPFGQLEDEFDISRVTKVCGASFVARTTVMQASAMDSMISEAVMHPGFGLVEILSPCHTQYGRKNRFKTCVDMYKWLQKSSTPLEKYRELSPEKQEKAIATGIFEKRDCEGLEDKYARMRKSLRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST06</accession>
    <name>D6ST06_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871171.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1161"/>
    <dbReference type="EnsemblBacteria" id="EFI33822">
        <property type="protein sequence ID" value="EFI33822"/>
        <property type="gene ID" value="Dthio_PD1161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032587">
        <property type="entry name" value="DUF4911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16256">
        <property type="entry name" value="DUF4911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="85" mass="9814" checksum="9DD8F74D7A82B4AA" modified="2010-08-10" version="1">MSFTPLFSRRVYVELERKDIALFKFLLESMDNLAYMSVVDKYRAVVQLVYAPGSEDDLDNFLAAAGREINLKVVYRGALKNEKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST15</accession>
    <name>D6ST15_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS modulated sigma54 specific transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871180.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1170"/>
    <dbReference type="EnsemblBacteria" id="EFI33831">
        <property type="protein sequence ID" value="EFI33831"/>
        <property type="gene ID" value="Dthio_PD1170"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="149"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="464" mass="52695" checksum="474D18686A7AAABD" modified="2010-08-10" version="1">MLKNQRVNIYCKDIVEIMQEGLLVVAEDGTIQMVNHALENITGYSKEELLGQPCSIFKCDACKLLRQASSGAWCRLFERKEQVKRKCHLMRKDGSYITVLKTAAVLSDDQGQTMGAVEIVTDISEMDRLDRQLRQLTRTLDEESSFQGIVGHSRQMKNLFELVEKAAQSDFPVFICGESGTGKELVAQAIHNLSPRAEQPYIQVNCAALNESLLESELFGHVKGAFTGALQHRKGRFEAAHKGDIFLDEIGDLPMAMQVKLLRVLETKTFERVGDNRTISVDLRFITATNKNLPDLIARGGFREDLFYRINVIPIHLPPLRERKEDVPHLVDFFIKRLSRKNKKNIQGLSPEAMRIFMQYSWPGNVRELKSALEYSYVLAEGDRIRSENLPEYLKDGGNDFQAVDLPPAPAENLQQRQKQELIEALKQSSGNKSQAARLLGINRVTVLNRMRKYGIDLQRDVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST29</accession>
    <name>D6ST29_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1184"/>
    <dbReference type="EnsemblBacteria" id="EFI33845">
        <property type="protein sequence ID" value="EFI33845"/>
        <property type="gene ID" value="Dthio_PD1184"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50318FT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="57" mass="6789" checksum="9458A3EC8462A69C" modified="2010-08-10" version="1">MNTLHILKSEPDELTRYIVDADCRDNNCQTVETFKPGTDWEKIVEQIFEADKVICWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST44</accession>
    <name>D6ST44_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar protein FlaG protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871209.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1199"/>
    <dbReference type="EnsemblBacteria" id="EFI33860">
        <property type="protein sequence ID" value="EFI33860"/>
        <property type="gene ID" value="Dthio_PD1199"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1913585at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005186">
        <property type="entry name" value="FlaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035924">
        <property type="entry name" value="FlaG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37166">
        <property type="entry name" value="PTHR37166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03646">
        <property type="entry name" value="FlaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160214">
        <property type="entry name" value="SSF160214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="116" mass="12574" checksum="0420E331C4ECB4CC" modified="2010-08-10" version="1">MKITNFDINPLAAPTLKTGGAQPKSAEETKTIVHPQTSAQDLDEDKILGAANSIKEYMSSMGVKLNFQFQGEGESIQVEVLDPTSDKIIRKIPSDEILSLAESIEDMLGVLVNKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6STB9</accession>
    <name>D6STB9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871284.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1274"/>
    <dbReference type="EnsemblBacteria" id="EFI33935">
        <property type="protein sequence ID" value="EFI33935"/>
        <property type="gene ID" value="Dthio_PD1274"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCBE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1022457at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088192" evidence="1">
        <location>
            <begin position="24"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="455" mass="49845" checksum="A7DC6C9B660AF8DD" modified="2010-08-10" version="1">MKRLVTLAIMVAFILGGFGVAQAIEFKAKGDWQIGVMGVSNPTFDSDDEVDEFQATTRVRTTFEFIANENLRGVMRVHSGDRTWGADGIGREGDDTGVSSFEYDQAYLDFMIPNSPVNMKVGKQPITFPGTFGSHIFDDTMWGVTATTPITDEVGMTLGWSRLDDQVSQGDDRNDEQDFFYAMVPVTLDGVDITPFGMYGMQGADATIGTTAGMDELEARESSEVWWAGVNFAVDMFDPIVISGDFNYGSQRSFDTDDVDAGSFETDGWIAALSAQYVMDYMTPEIFFMYESGHDESDMRDGEGGVMPSIGGDLYGMSTFAGSGSVLRGIGRAAFNNYDGAYGFSAFGATGKMAVGAKLGDMSFIDDVTHDLQLTYYQGTNDKDLRGVGDSNEDAFFTTRDHAWEVTFDTQYQMYENLSALLELGYLHPSMDSGHADGVEDDSAWKAATGLRYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6STG9</accession>
    <name>D6STG9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871334.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1324"/>
    <dbReference type="EnsemblBacteria" id="EFI33985">
        <property type="protein sequence ID" value="EFI33985"/>
        <property type="gene ID" value="Dthio_PD1324"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925503at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="130" mass="14105" checksum="D3D6A5C87D75C8B6" modified="2010-08-10" version="1">MPGIIIRWLILTVAVIICAYIVGGIHVAGFFSAFVAAAFLGILNALFRPILLLVTLPLNVLTFGLFTFVINAVLLLMVSGVVSGLEIHGFWSAMGGALIIALVSWALSSFVSDQGRLEYIELKKRGNRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6STJ4</accession>
    <name>D6STJ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871359.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1349"/>
    <dbReference type="EnsemblBacteria" id="EFI34010">
        <property type="protein sequence ID" value="EFI34010"/>
        <property type="gene ID" value="Dthio_PD1349"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744359at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="124"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="259" mass="27436" checksum="AC709B25EF0FFE5F" modified="2010-08-10" version="1">MQRNELAQLLQDLLDGHTSMDKAMERIGLEPYLETGQGLNLDMRRGIRTGIPEVVFGAGKSKKQLFTAVKHLAGRQQKVLVTRLGADAGNALAQEFPEGRYFEVPGLFELNSSIDLDHPWNGEAEAMIISAGGADLPVALEAYACLEFFGHTPGLVSDVGVAGLHRLFPHLPKISKARILIVIAGMEGALPSVLAGLCPVPIVGVPTSVGYGTSLNGITPMLAMLTSCAPGISVVNIDNGFGAACFAFKVLSRQRAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6STP1</accession>
    <name>D6STP1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1396"/>
    <dbReference type="EnsemblBacteria" id="EFI34057">
        <property type="protein sequence ID" value="EFI34057"/>
        <property type="gene ID" value="Dthio_PD1396"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="277" mass="31043" checksum="2E6EBA4F882ADBA0" modified="2010-08-10" version="1">MIIQNTQLVLFRTCRLARKLFYKENVMSYTARTIFLHNKYVFPLRVQEDTALHLMMHCLLVPPANLTTMMEAMFFSTIRKTIKGLWSLGVGLKVTSVNFFRPPVTVHYPRQVVPSLEGYRGHVELVPSAEDPGASRCIGCGACVRICPGACISIKVSHKRPHLAPKKTGKPPDHDQGHFLIPMPKARALPGIARRSPTSFKLNYNYCSLCGLCVETCPAGALAFSSNIYLAGYTRNEFKYDLLARLEYRARDKSRPAEGSRVQDNGRDNHSGGLRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6STV3</accession>
    <name>D6STV3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phage shock protein C, PspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871468.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34119">
        <property type="protein sequence ID" value="EFI34119"/>
        <property type="gene ID" value="Dthio_PD1460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="164" mass="18480" checksum="2FB180C324311972" modified="2010-08-10" version="1">MAEQIHSKNGLYRYQTKKVLGGVLAGLADKWDLNLTGVRLVVLGILLVVSFWKSFVALFMGSIELAVFYAFITPGLALFISVLVYIILWIILPVRGEEKPLNSQNDNSPESLAAKRIKDAYAQGDYALALHHAQLFIREHPDNHKVQDFQSIAEELLKKIKNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STY4</accession>
    <name>D6STY4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871499.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1492"/>
    <dbReference type="EnsemblBacteria" id="EFI34150">
        <property type="protein sequence ID" value="EFI34150"/>
        <property type="gene ID" value="Dthio_PD1492"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2039523at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="7982" checksum="BCDEFE2F5CE6DD72" modified="2010-08-10" version="1">MIEATQLTPKEIRSIGWDVLLKKLGPNGALQFILDYEKGYGNYCELRKEIFKDKTVQDLVQEMKNEGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU01</accession>
    <name>D6SU01_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871514.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1514"/>
    <dbReference type="EnsemblBacteria" id="EFI34167">
        <property type="protein sequence ID" value="EFI34167"/>
        <property type="gene ID" value="Dthio_PD1514"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="7"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="336" mass="39611" checksum="78C0E9BA95832CB5" modified="2010-08-10" version="1">MSFEIPNPHNACFKDFFKDPEFVKAFIKYHIPEEICSLLDLDTLQVDLSGFVSQEHREYYADVMVTVQIKGHTENVNIYILLEHKSTPQFLTRLQILNYEVQKWMDLKRKGQLQGYLPVIIPVVIYHGKGRWNYSRKFSDLFDLPSEVLRPFVPEFKHMIHDISSMEDDEFKTTAILEIFHLLFKYIHYPELETKLQEIYDLLETIPDKDKVKQYLQAIVQYVAVQGPISLERLGEYTRRLPGGDEAMQTAAQQIRQEAYNEFRQEKDKWERQAELKATQETLVDAATEQYGPLPRSLYEKIKSIRSLENLRALNRKVIRTRSLEEFTELVNQAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUA4</accession>
    <name>D6SUA4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871577.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32884">
        <property type="protein sequence ID" value="EFI32884"/>
        <property type="gene ID" value="Dthio_PD0198"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZH67">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2094392at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="142" mass="16265" checksum="BA6BC06DADD4DCD5" modified="2010-08-10" version="1">MFCTKCSYTSFDHLDHCPKCGYDWAAERRIFNVEWVQAPGDSWNFSSQEDESQEAEFYGDGALDGSRMEISGRSDEEEHSSMDFESRETKGDDTEFSLDLGKELEADDPETSGHNRTGQRARVEEEIEFPDLDLGFPENNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUB9</accession>
    <name>D6SUB9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871592.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0213"/>
    <dbReference type="EnsemblBacteria" id="EFI32899">
        <property type="protein sequence ID" value="EFI32899"/>
        <property type="gene ID" value="Dthio_PD0213"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1214676at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI32899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="252" mass="28132" checksum="367DDBBF139208EF" modified="2010-08-10" version="1">MLTIEDLFVKVGGREILKGINLQISDGENFILFGPNGSGKTSLLMTLMGFDGYEIVKGRIYYNDQDITHMPAYDRARLGIGMSFQRPPTIHGLKTRDMVKLCAGGREVDVDEMAKEVNFTELLDRDINAGFSGGEIKRSELLQLMAQDPGLVLFDEPESGVDLENMNLIGKVIRGILDGPLEPRNGISMKELKSRHQTSGLIITHTGYILDYINADRGQVLYEGKLCCTARPRDILDHISKYGYKECVRCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUH9</accession>
    <name>D6SUH9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">murD</name>
        <name evidence="17" type="ORF">Dthio_PD0273</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871652.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0273"/>
    <dbReference type="EnsemblBacteria" id="EFI32959">
        <property type="protein sequence ID" value="EFI32959"/>
        <property type="gene ID" value="Dthio_PD0273"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1093223at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="117"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="291"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="119"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFI32959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="433" mass="47041" checksum="E80B4CF5330012DF" modified="2010-08-10" version="1">MQEMVHKDQLKGHKAVVVGAGRSGLSAAALLESLGAGVRLLEKRTDFDVSQLDSRGLFNVEPVLGEHRPEHFQGADLVVVSPGISLAMVRGLCPAGQTVISELELASWFISEPVIAVTGTNGKTTTCMLIQKVLEKAGRRVFTGGNIGTPLSDHVLSGKRADILVLEVSSFQLQGCSGFTPHVGVLLNFSANHLDHHESEDEYFRAKMQLFARQGPMDLAVLPLDLRARVESDFRIKSNITYFAPTGRFHCPGLPGAHNQANMEAAMLACGFVDVSRNIFDQALLEFVPPPHRQEVFLQDKGVRYINDSKATTLEAMTAALKAFDSPIRLLAGGRYKGGDFSLLAGTLQEKAAKVYLFGDSREIFEDAWKNSADMEHFADLEQAAARAVQEAGPGDNVLLSPGTSSFDLFNNYQERGEAFKVAVRKATGITLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUJ2</accession>
    <name>D6SUJ2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871665.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32972">
        <property type="protein sequence ID" value="EFI32972"/>
        <property type="gene ID" value="Dthio_PD0286"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503322D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1608303at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046235">
        <property type="entry name" value="DUF6268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19783">
        <property type="entry name" value="DUF6268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6268" evidence="1">
        <location>
            <begin position="94"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="290" mass="32615" checksum="8EDA4529C34F9DF8" modified="2010-08-10" version="1">MKKCFFLIFCLLFIPASASFAGDQGMYYGGLESGAGVEHTFKSGVKGSDTEVSRTTYGVEASWSFLTLGYDHSRYSWDKPGDSDITDDGKEPFESLHNVYLTADVIFPVKDDWYLNLAAGVNTSFEKEMSRSLGTSARAVLLRVFDSGWMVGVGAVGGYHPVRSIWIPAAGFAYGLPGQEGWTARIGMPRTMVRYGFSEDFAMQAGADYSSRIYRLENNSSAVERGYFRKRDIRLSMQAEWSPLEEMTLEFGPYYVLSRKWQFYDRHDSRIGTWDLDSAPGLQAGLTWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUP3</accession>
    <name>D6SUP3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplA</name>
        <name evidence="10" type="ORF">Dthio_PD0337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871716.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0337"/>
    <dbReference type="EnsemblBacteria" id="EFI33023">
        <property type="protein sequence ID" value="EFI33023"/>
        <property type="gene ID" value="Dthio_PD0337"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="234" mass="25198" checksum="5350FF5220FF0827" modified="2010-08-10" version="1">MPKRGKRYIESRKNVDTTERLPVDDAVRMAIEASFARFDETVDVAVRLGVNPKHADQMVRGACSLPHGLGKDVRVVAFCKGEKENEALEAGADAAGGEELVEKIRGGWLEFDKAVATPDMMAQVGKIGRVLGPRGLMPNAKTGTVTFDLANTIKELKAGKVDFKVDRTGIIHAPLGKVSFGPDKIRDNLKALVETLQKLKPATAKGTYFRGLALSTTMGPGVKVDSTSLRGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUQ2</accession>
    <name>D6SUQ2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)H dehydrogenase (quinone)</fullName>
            <ecNumber evidence="4">1.6.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NAD(P)H:quinone oxidoreductase</fullName>
            <shortName evidence="4">NQO</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a quinone + H(+) + NADH = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a quinone + H(+) + NADPH = a quinol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="4">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871725.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0346"/>
    <dbReference type="EnsemblBacteria" id="EFI33032">
        <property type="protein sequence ID" value="EFI33032"/>
        <property type="gene ID" value="Dthio_PD0346"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008753">
        <property type="term" value="F:NADPH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01017">
        <property type="entry name" value="NQOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037513">
        <property type="entry name" value="NQO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="5">
        <location>
            <begin position="3"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="202" mass="21269" checksum="5A2559E1AC169210" modified="2010-08-10" version="1">MIIKVVFYSMYGHVLAMARAAAQGASRVAGARVDLRRVPETLSSDILEKMGALEAAKEMQDIPVCTVEELEEAQGIIFGTPTRFGNMCGQMRQFLDGTGSLWARGALVGKAGSVFTSSATQHGGQESTLLSFHTTLLHHGMVVVGLPYTFQGQMGTQEVTGGSPYGASTIADSDGSRMPSQNELDAAMFQGGHVAGIAARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUQ6</accession>
    <name>D6SUQ6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polynucleotide adenylyltransferase region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871729.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0350"/>
    <dbReference type="EnsemblBacteria" id="EFI33036">
        <property type="protein sequence ID" value="EFI33036"/>
        <property type="gene ID" value="Dthio_PD0350"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="5">
        <location>
            <begin position="198"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="482" mass="54053" checksum="FD1D37C3737CE447" modified="2010-08-10" version="1">MSPHNLHHPFSGSHAPCSPAAHSLSSLPDHPEIAAALDVIRIMKTLGFTALMVGGAVRDILLERPVRDVDLASDMPLESLRKHFRAFETGRSRLFHTLCIVHQGQHLETTLFRTKHSLPAERPDQEDTKHSLFLQDARHRDFTINAMALDEQLDLLDPFHGKKDLDRGLIRAVENPRERITEDPLRMLRAARLACELDFEIEEKTALSISGLARDISDVAPERLGREILKMASLSGPRFARGIRLLDRLGLLPVVLPEVDALKGLYHDPRHHPEGDVFIHTLRAIQCNDLAHDSLNMALLAHDLGKTDIAARHPGTGFYRGHDRAAEYIIRQMGQRLRLPGRITRAMQAVAANHMRMHGLDEMRPSKILEMVEHPHWALLARASVCDHAARGKEHGKLQQKKIALALKKIRPLLNEATGKTRPVITGNQVMQAAGIPPGPMVGRIIRETTAWARDNGIQDQNLILDYARNLAQELQKENTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUR1</accession>
    <name>D6SUR1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase U32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871734.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0355"/>
    <dbReference type="EnsemblBacteria" id="EFI33041">
        <property type="protein sequence ID" value="EFI33041"/>
        <property type="gene ID" value="Dthio_PD0355"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1264653at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="410" mass="45992" checksum="E8675AA238FE2EAF" modified="2010-08-10" version="1">MKDPAILPELLCPAGDLKRLQTVLFYGADAVYLGGTHLNLRSKAAGFDFESLPQALDLARRSKARVYFCLNAILPQKHLQKVRKYLELLAEIKPDGIIAADPGVISMAREHAPHIPLHLSTQAGTYNAPSARFWKEHGVDRVNLARELSLTDIREMSRQTGLPQLEMFVHGAMCMALSGHCLLSAHLNKRSANQGLCTHPCRFDYRARALALEERTRPGEITWQVWEEEGYSRIFSSQDLCLVRFLGWLRRQGISSIKIEGRMKSVSYLGVTTDVYRTALDDLARGDFRPGLYLEELASVSSRPLGSGFFLPANKIFSKPALESGRKKILASVEKKLGGQRWLVQVKSRWSRDMDLELVLPGLERPGLRQGDYLLEGINQEELQTAHSGQQVVLTTGNELVTEHLLLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUX7</accession>
    <name>D6SUX7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871832.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0017"/>
    <dbReference type="EnsemblBacteria" id="EFI32733">
        <property type="protein sequence ID" value="EFI32733"/>
        <property type="gene ID" value="Dthio_PD0017"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="10677" checksum="8D6144EC0774BFF7" modified="2010-08-10" version="1">MEQQLFDDLVSSLKEAKKISHGESQPSRRFEVSSTDVKSLRERVGLSQSEFARLMRVSVKTLQNWEQHRRKPSGPAAALLTIVSKAPDVALKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUZ8</accession>
    <name>D6SUZ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase YhgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0043"/>
    <dbReference type="EnsemblBacteria" id="EFI32754">
        <property type="protein sequence ID" value="EFI32754"/>
        <property type="gene ID" value="Dthio_PD0043"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="31"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="356" mass="41625" checksum="42C8AAA33E7DF67D" modified="2010-08-10" version="1">MVLFPWHLKFPLAYLKTMPYSPFMSDTSKYHDHTFRAILGREPVARDFVRYHLPEEITRDMNLDTVKVSSRSYVSDNLKESMTDIVITLELITGEPAEIYILVEHKSDLDAWTKIQLFKYMNEVWQSFIQKKTGTLPIIVPLVFYHGTARWNYSLEFSDLFNLPSEHYRKYIPKFEHLLHEVPVINKKKVKSSITLEVFHLVLEYIFYPEKRDQIYEALELLFKGLDAKEAHEIFAILIKYLLIATDETPEEAEEKVKHLPKGGETVRTTAEVLEERGYNKAIKEKPVWEKQAELKNAHETLIDIATEAYGPLPGMVHEKIKSIQSLENLRALNRKVLRTQSLEEFTELVNRAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV58</accession>
    <name>D6SV58_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2281 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871896.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0116"/>
    <dbReference type="EnsemblBacteria" id="EFI32814">
        <property type="protein sequence ID" value="EFI32814"/>
        <property type="gene ID" value="Dthio_PD0116"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2075077at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018739">
        <property type="entry name" value="DUF2281"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10047">
        <property type="entry name" value="DUF2281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2281" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="64" mass="7622" checksum="8363828F177C9194" modified="2010-08-10" version="1">MNTTEVVINEIKQLPEPLQREVLNYAYFLKHKAEQDSLLKAQLFSMEQIWSNEEDEAWNNVPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SJZ2</accession>
    <name>D6SJZ2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869317.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3651"/>
    <dbReference type="EnsemblBacteria" id="EFI36195">
        <property type="protein sequence ID" value="EFI36195"/>
        <property type="gene ID" value="Dthio_PD3651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI36195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="192" mass="22072" checksum="99EB233EFF3B87FE" modified="2010-08-10" version="1">MTAVPLPTSYPELDTPEVPDDYVSEIRPVDPGKHVAPLQEPVDSEEALNGQYSGTTSAEPYRQPNIRQFPPAYKTLKKKVERIKVVREFEGIVDEVDKENGIFLARMIDLTAGKTFEQEEGEFPIDDLRPDDLPLLEEGALFRVRVAYRIKRGGMRQRFTELVFRRLPCWNERHFESAKQRAAELAAYFSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK34</accession>
    <name>D6SK34_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SpoVT/AbrB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869359.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3694"/>
    <dbReference type="EnsemblBacteria" id="EFI36237">
        <property type="protein sequence ID" value="EFI36237"/>
        <property type="gene ID" value="Dthio_PD3694"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZTZT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="9430" checksum="BDAF0D0C2558238A" modified="2010-08-10" version="1">METTRVIQTEHSQAIELPQEYQIDADRVKIRRYKNTLIIEPLPENWDWLDEVIGPLDTDFEQAVAEQPAVQSRAELDFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK36</accession>
    <name>D6SK36_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3696"/>
    <dbReference type="EnsemblBacteria" id="EFI36239">
        <property type="protein sequence ID" value="EFI36239"/>
        <property type="gene ID" value="Dthio_PD3696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="60" mass="6631" checksum="40B9116BA30BE0C5" modified="2010-08-10" version="1">MMTNAGYARNPVICYLLFVKIKTCIYPNWDSPRNNTGSGSLQASRAREDFFGTPVECPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKB4</accession>
    <name>D6SKB4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869436.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3782"/>
    <dbReference type="EnsemblBacteria" id="EFI36317">
        <property type="protein sequence ID" value="EFI36317"/>
        <property type="gene ID" value="Dthio_PD3782"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="108" mass="11932" checksum="C63C2E8584072317" modified="2010-08-10" version="1">MIKTVIRNFLFDAIKFTPRGGRIMILSSQDGRHAVVSVQANGIGMVQEILSSIFSVKKKQWQIVTEGEKGTGLGLILCKQFIEQHGEKIWIESEPGQGTTVSFTLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKD4</accession>
    <name>D6SKD4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869456.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3804"/>
    <dbReference type="EnsemblBacteria" id="EFI36337">
        <property type="protein sequence ID" value="EFI36337"/>
        <property type="gene ID" value="Dthio_PD3804"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="181"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="248"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI36337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="521" mass="55949" checksum="F5036D06FEA00D74" modified="2010-08-10" version="1">MDSGKKIIIFLITGIILMAVLAVGVLLTTEQNASAALVVAVVGALIMAGNLILVRRLLCDIHSAGRLAANLAQGQPLKQIEENRFQHGQLSGLVESVYKASSVLKYEKGLKSGIIEGLPMPFLLVDTQERILFTNQICMDMLQIDTSPSEQLGKTLAEVFYNDPGRKTAVGKSITQGEVFKNLEVVITGHKGRQTHVLANVYPLYDLDDQCIGGCCIYLDMTELKDKEEEIKRQNQLISDTAAKAITISDNVASATEELSAQVEQASRGTEEQTNRIGETATSMEEMNATVLEVARNASGAAEQTDAAKAKAEEGAGVVKQSVDAIKEVQEQSRAMKENLGSLGKQSEEIGKVMTVIDDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMNATKEVEKTVSSIQESTRSNMDSMDQSVQAVEKATELANSSGQALQEIVNLAQEAADQVRSIATASEEQSSASEEVNKSMEDVNRIARETADAMNQSAQAVSDLANQASELKKIIEDLNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKD8</accession>
    <name>D6SKD8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869460.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3809"/>
    <dbReference type="EnsemblBacteria" id="EFI36341">
        <property type="protein sequence ID" value="EFI36341"/>
        <property type="gene ID" value="Dthio_PD3809"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1579676at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088090" evidence="2">
        <location>
            <begin position="28"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="402" mass="45099" checksum="2F09BD777E00BF05" modified="2010-08-10" version="1">MPSRRFMRIFKYHAVFMAVLLITGLSACNGDNPEQSEQQEAPPSKVSYQEVHKTDVQVFRQYPARVHGSSTVQVRSRVEGILEEKLYQEGEVVSKGDELFVIDQEPFEIALRQARADLEDARAGYDHARRDWKRYSRLYEQGTVSEQTRDEARTEYQLAGAAVSRAEANVEDARRNLRYTRVSAPVDGITGMEDVSEGNLLSWGDLLTTMTRNDPVHVRFSIPQEEAVARRMAAQAGPEEALPPKSLLEGARVGREGLDVLLARLMPDRDQKYPHKGVVDFTASTVDPDTGEVAYRAVFANPDQELMPGQFVRVRLLLQNLEDVFLVPESAVGQDQEGPMVFVLDEDNVAQVRHVRLGPVLEDGWAVFEGLQEKDRVVVNGQVALEDGEQVQARPAENPETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKP4</accession>
    <name>D6SKP4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868388.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35255">
        <property type="protein sequence ID" value="EFI35255"/>
        <property type="gene ID" value="Dthio_PD2666"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZTUH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2203756at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="255" mass="27971" checksum="9962931BA106E4CE" modified="2010-08-10" version="1">MQFSKANQRGAFFAIQGLPGHNGTQTDNACMKTSSIKKYESDSQTAGVTMIELGMVLAVIGLILFAAIGAWRSVVESRQIARTTSVMQQAKNCLVERMVHSLQYPTYSDLQTDQQEPAQCISHDPQKDVDDCLCRPGIRDAWGNRLRFVEGITEDGNSLQGEYAVDIPYRETEAVEPASDSSAITEAGDKTGIAFILISPGPDGLLDEQVWPDNCFDDQDSITGSLADCTPDFTKRNDDQFLIITGHELRAILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKQ3</accession>
    <name>D6SKQ3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thiamine biosynthesis protein ThiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD2675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868397.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2675"/>
    <dbReference type="EnsemblBacteria" id="EFI35264">
        <property type="protein sequence ID" value="EFI35264"/>
        <property type="gene ID" value="Dthio_PD2675"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="505395at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="430" mass="46457" checksum="8CFB31A69B4B22AD" modified="2010-08-10" version="1">MKTQLQKARAGVVTPEMHTAAEGEPISAEDLCSLIARGRAVLPKNAVHDFASIKAIGEGLKTKVNANLGTSGECADMAAEEKKLAAALRAGADSIMDLSTGGDLDQLRWMFLKKSPVMLGTVPIYGLAAKMLRHGRPMHDITPEELFREIELQCSQGVDYITVHCGITTQSVQRLEHFKRIMPCVSRGGSMHMQWIRANGQENPLYQDFDALLDIAEKYDVTLSLGDGFRPGCIEDSLDGAQVEELMILAELAGRAFERGVQVMIEGPGHVPLNEIKTQIQLQKKLCRNAPFYILGPLPTDIAAGYDHITSAIGGAVAGAAGADFLCYVTPAEHLALPAEDDVYQGVMAARIAGHIADLSKGLPGSADKDRKMAHCRQTLDWEGMIKSALDPDLVRSRMQIAEDGRTCSMCGKLCAVKTSEETQALQAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKQ4</accession>
    <name>D6SKQ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2676"/>
    <dbReference type="EnsemblBacteria" id="EFI35265">
        <property type="protein sequence ID" value="EFI35265"/>
        <property type="gene ID" value="Dthio_PD2676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="79" mass="8751" checksum="9CEF948EB145D704" modified="2010-08-10" version="1">MKGRGHLFPGLKRILDQFRLLTMPPTGITLTVTIQGVPKSAWGQSPRHIAFTITNITSAKFRDPAQTYTARDSPQALCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKV3</accession>
    <name>D6SKV3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2729"/>
    <dbReference type="EnsemblBacteria" id="EFI35314">
        <property type="protein sequence ID" value="EFI35314"/>
        <property type="gene ID" value="Dthio_PD2729"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="434" mass="49135" checksum="7C151FFDFD034B2D" modified="2010-08-10" version="1">MELLHFVSITGILVLLILACTWNFPLFFFGLHIFSRSILDSIPYVTYSDIYAGFSVMQIYSIFVVAYLSMYLFFHRDTQVRSIPAAIPVLLVILSFMVSGIISNDWRPILENTTKWIYMILLAGFVFHILKTNTLDSLIRVLWLSLLPAVFIQFMAIITNDYVITSAGHIGYFGGYQHQNMISYYLLGFTSCSLYLAVQSDKLFYRLFFMLSTGYGIFAVYACGYRTTLIALMIFLIITYLYSIKRLDLSKKLLAISFMPLVMIVGIYFAGGEIFHRLSDIWVFLQAPMDHIDFSGNASMTSLFSGRIYIINVLMHAYLSSPFESLWAGMGLDSARQIIGTYPHNEFLAALVESGILGLSAFSLFVVTYLWTVNSGDFVASVKESVIAGTGTGLLIMTLATMPFRDMRAMILFGVFLGIAHFSIYMRRQKPHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL60</accession>
    <name>D6SL60_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868553.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2841"/>
    <dbReference type="EnsemblBacteria" id="EFI35421">
        <property type="protein sequence ID" value="EFI35421"/>
        <property type="gene ID" value="Dthio_PD2841"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50336CU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1587964at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="18712" checksum="4C55571013358805" modified="2010-08-10" version="1">MDQKQLLKLVADLYKFSDENKTFLHTRLSVGEDQLGPYKKIIDECLSPDVFSNKPIQVAKAKKAISSYSKALGDDLGQAELMVYFVECGNKFTLAFGDLYQEYYDALNRMYKRAIDKVLALPDEQQNEFRQRLKAIMTSSSNIGWGYHDTLADDYYSAFDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL68</accession>
    <name>D6SL68_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MotA/TolQ/ExbB proton channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868561.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2849"/>
    <dbReference type="EnsemblBacteria" id="EFI35429">
        <property type="protein sequence ID" value="EFI35429"/>
        <property type="gene ID" value="Dthio_PD2849"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MotA_ExbB" evidence="7">
        <location>
            <begin position="83"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="23129" checksum="703F2E856CF99F97" modified="2010-08-10" version="1">MYDYFVSGGPVMYPLLACSIIALTVTIERVIFWTLVHVRRDPALVDEVLDLYRLEDWESIKQKVSGSRDFVIRVLVSGILHRDFSMGKAMESAAGEEIKRMQRFNGVLDTMITVAPLLGILGTVIGIIHSFDILGQTGGIEEPREVTAGIAQALITTATGLVIAILALFPFKFFSSRVEDAAAIMERYATSLEIVHEKQQQGAARQEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLA2</accession>
    <name>D6SLA2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868595.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2883"/>
    <dbReference type="EnsemblBacteria" id="EFI35463">
        <property type="protein sequence ID" value="EFI35463"/>
        <property type="gene ID" value="Dthio_PD2883"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1816478at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="5"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="199" mass="22801" checksum="A166D0CE04C92738" modified="2010-08-10" version="1">MHADKKELRAAMLRQRSSLDPGEVNAKSAAVIENFLSTKKLMQHTCFLVYLPIKSEVDTKPLLRELLQQGREVYAPYCDPHRPGRMEFYRVQDLSCLRPGFCNIYEPEPKQENIFENHAPSVAVVPGVAFDESGYRLGFGQGFYDRYFSLLSDPGPLLAGFAYDFQVVERLPADPWDIPMHFIFTETRTIEVFTQNKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLD6</accession>
    <name>D6SLD6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Nitrogenase molybdenum-iron protein beta chain</fullName>
            <ecNumber evidence="5 9">1.18.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dinitrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate</text>
            <dbReference type="Rhea" id="RHEA:21448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17997"/>
            <dbReference type="ChEBI" id="CHEBI:18276"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.18.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[8Fe-7S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21143"/>
        </cofactor>
        <text evidence="9">Binds 1 [8Fe-7S] cluster per heterodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NifD/NifK/NifE/NifN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.6.1" evidence="5 9"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868629.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2920"/>
    <dbReference type="EnsemblBacteria" id="EFI35497">
        <property type="protein sequence ID" value="EFI35497"/>
        <property type="gene ID" value="Dthio_PD2920"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="397330at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016612">
        <property type="term" value="C:molybdenum-iron nitrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018697">
        <property type="term" value="F:carbonyl sulfide nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000318">
        <property type="entry name" value="Nase_comp1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005976">
        <property type="entry name" value="Nase_Mo-Fe_CF_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01286">
        <property type="entry name" value="nifK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00699">
        <property type="entry name" value="NITROGENASE_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00090">
        <property type="entry name" value="NITROGENASE_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="10">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="458" mass="50560" checksum="E30E564FC401A2BA" modified="2010-08-10" version="1">MLDHTPAEVTSRKALRVNPAKTCQPIGAMYAALGIHRCLPHSHGSQGCCSYHRSHLTRHFKEPVMASTSSFTEGASVFGGSPNLRQSLKTIFQAYDPDVVAVHTTCLSETIGDDIPTIVKKAEDDGIVPRGKKVIHASTPSYVGSHVTGFSNMVKGIASYFTHPAEHKIKDQINVLPGYVEPADMRKIKSMVSEMGLKQLVFPDTSDVLDTPKTGEYSMYPKGGIKMQELEQTGNSLHTIAMGHFSSLEAATYMDQKAGVPFTLCDIPIGVQATDRFVQAVMDATGASPTQAMLDDRGRLVDMMTDYQHYLYGKKVALWGDPDQIISMAEFMVSMGMQPVYVLTGTPGKAFEKRMKKILNDTVPNAVFGHSQDLFYLHQLIKQEPVDLLVGNTYGKYIARAEDIPFVRFGFPILDRTGHSYFPSVGYKGGMHFLSAMINTLLERMDRDSPDECFELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLG2</accession>
    <name>D6SLG2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868655.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2947"/>
    <dbReference type="EnsemblBacteria" id="EFI35523">
        <property type="protein sequence ID" value="EFI35523"/>
        <property type="gene ID" value="Dthio_PD2947"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032PIQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="976408at1224"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="424" mass="46845" checksum="6B915C2880B6A519" modified="2010-08-10" version="1">MLKKLVMCLMGLVLLLAWWYPAQHLVRIEPVDLESRFERFQNPTWMGITPTFGLPLEMTGGNRQDVSFEQFRSAFMQAADVILAADSKSWSSLADKLSSQGQVYLGPEQWPLPWPAEYRGPRTAVLEKEEDIQLLQLAWLGPQDVFGADLGWQDRHPLRLFATLAGLVMLATAGLAWSRSNTELIPSASDSRIGTTLACCLGLILVGAAMICMPHLYGIWGRGDLGFAAFFVGLFLCLSGALSALVFLGPYKYIQALLQGEKRLIKWSYTPAEWQNFVHTQYDIERGDMLQKLAFIGLVLLAAALVVSWLAGVLAVMIISGVFFALVFTAVSVPVFSRRRLLRGPFEAHIGLKGLYLGGQTHTWTGFFHRFQSAAVETGANPCLVIHYFQLGHGGGDILVRVPVPAGREQEARQAAQDLESAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLH3</accession>
    <name>D6SLH3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2958"/>
    <dbReference type="EnsemblBacteria" id="EFI35534">
        <property type="protein sequence ID" value="EFI35534"/>
        <property type="gene ID" value="Dthio_PD2958"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161694at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="692"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1211" mass="134631" checksum="B72E795BE61A3E31" modified="2010-08-10" version="1">MNNDLCLKFFLQHLICIGLIVFLALLSPCRAMSAVDPVLYTDKELWAIGNLWKQTEVAWDAEMQAYRDNLAQIENSPMSETRKKYFMQREVSRHRAVSQELGRKRHQVHQAVLNESSARAGNSRSILRQRIDASLGTSIDDRAHRGLMGDLDAAGGAVAVDNVESVLQDMGLDHLTVTDSPATLEVGAPTPWGDDPFDLTVHKQGLPAQVGSEYHRIQIENHARNHEVFVSASMRDPVTGKTRAGAGYVEVQDHLKKASGGLNSSSGDLAGNPELMQPMAKSVDKTLRVSELPDEELGSILERHGIRESPQEFRRKLNNIKEARTVVSDPSEAGRMRQAAAEIFDSAESRTLQRANQELRAREDALRRIDENMRRLDNVSDTEATRLRKERLQQSYQQRQSALRQEITDSRARMQATAAANGRKPVIELTGPETPAGPTRMQQLGSGARRAAQVYGTVTDFTDIGHLGQTLEDYMEGDASLFDVARQGLRVPPLSATPVGMVAGGAETIVGTSKRMGQSIVDARDAHLTIRQANENNLAAYLTQWEIRFRRAGMDPGEARAYVAASVEAGNLDVLEARAEALRAAGAEIESPELVIEDGIGPDGGKLYMLYNLGDVVYGMGESVYSGAAYTIRAPGRIVESWAEGELAEAVLEYDSRTAEADMRVQMFRALRNAGIERDKALQAVNEGGSFMRSVFQEARELQEQARLEQERLEAEILDLEQRINRILSEINRLRWMDITVHTTPPSPMNIPYDPDADEDMVFEVEISLGGGFQNTVNRIRHGIRDAAGQDPDVSVTYEISLPGAQETEPGQWLAEIPAVPEAYPFLVDIEVNISGLDGHFSFMQRTVRRQTGDVLLLLAAEEKIEFQESQYSFTDGDYEPVHAVVSNLNPDSTYYYYWTFMEQDGITEIPAWKLHAILEDSEEPQSFTATVSLADIRTGLLLDEDQAMVHVHPVEILEETITMDLFENRTYWTTATPFANDPTVRFPEATIIATPGISGIQEEISEYSSDWERLQEMLHPKESVEDIMKQHMQAELEKMGMELSEAQMAQALQMAGGLTGLAGEQGIEPPDLLGSGYVYPGEPVELDLTVSVPMPPRFRVMFPSPQGAASLDAEVRVKHWMLSTGFMYSPRVRGNNAATSISWVPEPDEHTESFSLELITNYSIDFFKAGTDEPLVEDGIPLRYDPMTTYFTLGFFFLPLKEPPGTLETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLI5</accession>
    <name>D6SLI5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868678.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2970"/>
    <dbReference type="EnsemblBacteria" id="EFI35546">
        <property type="protein sequence ID" value="EFI35546"/>
        <property type="gene ID" value="Dthio_PD2970"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="403" mass="44170" checksum="013CA16184379FCE" modified="2010-08-10" version="1">MREQAGKTHNSALDKLGRRDFLSLAAASGLVVLAGCATRQKDIETVNNADSSPLWQQDKKTIVLSSNENPFGASPAAMEAGMKALRDNASLYARENKDRFLNDLADFYGLDPGQILLGCGAIELLKIATDVFCSSKSPPVISDPVYEAISYYAPLRRIWPKRVPVKTRDAGHDLGTMLEAAKSYKGMLYVCNPCNPTGTLIGEKDLSQLIKEVPRETVVVVDEAYAEYVGSGFFSCMDLVRAGTPNLLVIRTFSKIYGLAGLRVGYCAGAKNIIQAMSGHALWNNINQAGLAAAHAALYEQSWVDKMCRENKRTRRNFCAGLEDLGIEYIPSRTSFVLLSTGRSWEETHNYLLLKGGVVAGRKIPSLPRYIRVSLGSDKDMEHVLSLLKNLQSSPPTQKKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLR8</accession>
    <name>D6SLR8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD3058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3058"/>
    <dbReference type="EnsemblBacteria" id="EFI35629">
        <property type="protein sequence ID" value="EFI35629"/>
        <property type="gene ID" value="Dthio_PD3058"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI35629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="270" mass="28258" checksum="37F551EBE56462B6" modified="2010-08-10" version="1">MIFLVYDRHQRSTLKLYSNNPLQALIYSILAGSSTALGALALMFMGPPGKRTMAALLGFAGGVMLAVSVFELMPEALELGSMTVLVTGFLLGCLIMYLLDRLMPHAHLSDSEHLEVENPERLGIRRSTMLRTGYLIFIGISMHNIPEGLAIGAGIESSPELGLIIAVAIGLHNIPEGLAVAGPLKAGGLSNLKVFLFTLGAGLMTVVGAALGLLVFGISEMFISGGLAFAAGAMIYIVSDELIPQSTSMHAHAANAGLIGGLLLGFVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLV8</accession>
    <name>D6SLV8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein Dthio_PD3098</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3098"/>
    <dbReference type="EnsemblBacteria" id="EFI35669">
        <property type="protein sequence ID" value="EFI35669"/>
        <property type="gene ID" value="Dthio_PD3098"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="119" mass="13304" checksum="5141261D38D33712" modified="2010-08-10" version="1">MQADELIMPLRGQGLIRYSDTCMQFLERLDPETWILRVVLKPGADRDEVLGIHAGRLKISVKAPPVDGKANKALCIFLSRSLGIRKKQVWIQRGLQSRNKDLIVSGVAGTVFNALKHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM17</accession>
    <name>D6SM17_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868857.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3157"/>
    <dbReference type="EnsemblBacteria" id="EFI35728">
        <property type="protein sequence ID" value="EFI35728"/>
        <property type="gene ID" value="Dthio_PD3157"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200083at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088108" evidence="2">
        <location>
            <begin position="20"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="672" mass="77733" checksum="63ED6C7371A62B43" modified="2010-08-10" version="1">MKRIILTLCLALFPLQAGAERWDNQDEYLEWLKEYGALDIYAHNLLQASPGTPEKLEYAEALLEMGDPGQALEVLGRIEAQDRDDYKGRLLFLQSRSHRQKEDFDQAVLHAVQSSDYLGKDRTAELMHQEQGLSFLWQAVWKRWYFSSLSVDDISQGRKQIMLQALSLGSKAWPEESFWEEVAGPFSEAAQDVSQDPALDRVSSSDRKKVSQVLAAWSMGHWSMADRNLQDIQDRDLRNFWKNLGDFLQTESFSRWSGDLKHPKSRGFKDIFALNLQEYALNSFELGTPDQGSWPSFLSRIKDRSESEALKSVRQELTSALLPQEVRAGLTSLEFIFTLQNQDFEQAENVWKDLLDKDVNLPFTLHLSAALLTGEYQHLNDLPGNQYPFFKELLNAAGMNIEKRFSADFWGDDQEDLQILKDSYPLDYSINYLFWEEKFQGQDDTEAARNLAFLFPSAQAGQSAYLFLAQDAYEQGHKELAWRYLEQISQEFAQGDKQLDVLEAKAGILMDMGREEESLQTYQVLLSRDPQRLEPQRRLNLALMIQEKGRWSEAEEILSSMWEQREDFEKGIQAEILFWLGEGAQHQGRLEDALDKYLRLAWEFPEENIWAVTAMYRAGLIYEQREMYSVAARMFEKVIRNAGRDSQKKAAEQRLDSVESRQKSDADGMFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM45</accession>
    <name>D6SM45_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SSS sodium solute transporter superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868885.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3186"/>
    <dbReference type="EnsemblBacteria" id="EFI35756">
        <property type="protein sequence ID" value="EFI35756"/>
        <property type="gene ID" value="Dthio_PD3186"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="515" mass="54334" checksum="98DE82C6F379AD74" modified="2010-08-10" version="1">MEVVDTAIGEPSTTSILFFLVFICATLGITYYAAKKSQSASQFYAAGRGVTGLQNGLALSGDYMSAASFLGIAGLVSLRGFDGLIYSIGFLVGWPILMFLIAEPLRNLGKFTFVDVLAYRLSKKPIRIAASVGSLMTVFFYLIAQMVGAGTLIMMIFGMPYEIAVVIVGMVMIMYVLFGGMLATTWVQIIKAVLLLSGGSILVFLIMLHFGFSYGELFSQAAMSYGDRVLEPGGLVASPMDAVSLGIALMFGTAGLPHILMRFYTVRDAKTARKSVFYATGFIGFFYILTFTIGFGAMVIVGQDIISAIDSGGNMAAMLLAEATGGAVFLGFMAAVAFATILAVVAGLTLAGASTLSHDLYAGVFRAGRSTEEEEVKVARIATLSMGVLAIVLGLIFQGQNVAFMVGLAFAVAASANFPALVLSILWRNYSTFGAVASIATGTTLAVGLIVLSPTVWVDLLRNPTAIFPLSNPAIISVAGAFAAGYIGSRLRPDAEASSRYDEQKIRNYLGVGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMA2</accession>
    <name>D6SMA2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
            <shortName evidence="4">HDH</shortName>
            <ecNumber evidence="4">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisD</name>
        <name evidence="10" type="ORF">Dthio_PD3248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 9">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868942.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3248"/>
    <dbReference type="EnsemblBacteria" id="EFI35813">
        <property type="protein sequence ID" value="EFI35813"/>
        <property type="gene ID" value="Dthio_PD3248"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7 8">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7 8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7 8">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7 8">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="436" mass="47787" checksum="C33576C14F64C0AC" modified="2010-08-10" version="1">MFGRQFSYTSTHDWPHIKSWLTLRMQPDMSVEGKVREVMNKISKSGDEALVEYTRLFDCEDFSLENLRVTQTEIQDSMSMIPGNDLKIIRTAAEKIRNYHLKQTRNSWFTTDPDGAFLGQMVTPLPRAGLYVPGGQGGDTPLISSLLMNAIPAQVAGVESICMVSPPRKDKTLNPYLLATAHLLGLDEIYKCGSAWAVAALAYGTPEIPAVDMIAGPGNIFVTTAKKLLMGQVGIDMIAGPSELAVLADSSARPDYIAADLLSQAEHDPLAGTYLVTDDADLIEKVAHELENQLLSLPRADNARKALKDWGGSFEVPDMQTGMELVNRIAPEHFELCLQDPWPMLARVKNAGAVFLGHTSPEPVGDYFAGPNHVLPTLGTARFSQALSVENFQKNISILATDKSYLQQHASGIARLARMENLEAHARSVEIRLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMF5</accession>
    <name>D6SMF5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35866">
        <property type="protein sequence ID" value="EFI35866"/>
        <property type="gene ID" value="Dthio_PD3305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="64" mass="7199" checksum="03E6FA6F068D1E20" modified="2010-08-10" version="1">MQSAASGRRLLILSIYACHASLAWLILSKFLVFYDKISAVSHIGVWHKFEPDRLVTSSDAPRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMH8</accession>
    <name>D6SMH8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate uptake regulator, PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869018.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3328"/>
    <dbReference type="EnsemblBacteria" id="EFI35889">
        <property type="protein sequence ID" value="EFI35889"/>
        <property type="gene ID" value="Dthio_PD3328"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194652at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="120"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="3">
        <location>
            <begin position="384"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="548" mass="63819" checksum="6D0AE2545DE9559C" modified="2010-08-10" version="1">MPYFSDLEEKIHFMVLEVNRQLDDTLKIIQDPDPRLVDKVKSRDDRIDNYKVIIENLCFSRIHGEENLSKKQVDFIRATNIISNNLEKISDFSVYIVDQLNYLSSVEYLHNYNYQPFFQHLSSSLDMVVQGLFTRDLNHALNICRTEFVIDKLFKRVFDQIIEELDTAPNKQNIITCLFIFRYLERMGDALLNIGEAIIFSVFGEKLKIHQYQALVENLDSINNDISIQDVGFESIWESRSGCRIGKIMDSSRSGSQGVLFKEGKAEKISREKENIESWKKIFPSLVPKIFSYTQSRKNASMLLEFLPGCSLQETVLTQDRDTLENALFILKETLSITWKDTLKNKQVSSGFMKQLAQRIDDVLMIHPEFNFSEASIGSLTTPSLEDVIRILSEVEAELNAPFCIFIHGDFNTNNIIYNQKEQQIYFIDLHRSCYGDYVQDVSVFLVSNYRKPVFDAGIRRLINRLNQDFFNFSRRFAAENADETFDARLAMGLIRSFFTSTRFELNQEFALGMYQRALYLAEKIIAHRGRPWREFSLPPDVFKYASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMW6</accession>
    <name>D6SMW6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD3469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869155.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3469"/>
    <dbReference type="EnsemblBacteria" id="EFI36027">
        <property type="protein sequence ID" value="EFI36027"/>
        <property type="gene ID" value="Dthio_PD3469"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="7">
        <location>
            <begin position="87"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="8">
        <location>
            <begin position="325"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="9">
        <location>
            <begin position="461"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI36027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="573" mass="62782" checksum="70C5A2CEF537D2A4" modified="2010-08-10" version="1">MNNTWNSRVNWKLIQTSASPAHIARLAEDLEISPALCSILHQRGMTSLEEMQFFLSPGLRYLQPLEDWPQLQQAADLIASSHDSGNRIAVWGDYDVDGITSAALLKDFFQSKGIDIRCYLPHRVQDGYGLNMAGMEKLAGEGIKTLITVDCGISHHSEISRARELGMHVILTDHHLPGSELPPANVIVNPQCSPCPYPGLAGVGSAFFLAAALNRTLPGPQMDIRDLLDLVALGTIADLVPLDRANRILVKNGLLLLSEGRRPGIYALKEASGLGGTDSIGAGQVGFALGPRINAAGRLDDPCQALELLLCRDLQQARTIAARLNTLNNERKKTEETILDMARQQANNYKDDSGLILFDPDWHPGVLGIVASRLVEEFYRPCLVLTRENGLIKGSGRSISGFNLYQGLCSLKSHLTGFGGHSQAAGLSLEPENLEELRTGFSRVISECIGPGPHQKEIVLDALLGLDELSPDFLQELELLQPFGPENPRPVFLSPPLKVLDQSLFGKDKHVRFDLKDPESGVKLRGQFWRQGRNLKETSLKGKNLTLAYTPGINVYQGLVSIRLNIREILEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN12</accession>
    <name>D6SN12_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3520"/>
    <dbReference type="EnsemblBacteria" id="EFI36073">
        <property type="protein sequence ID" value="EFI36073"/>
        <property type="gene ID" value="Dthio_PD3520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="61" mass="6774" checksum="3D40E956EFBE806E" modified="2010-08-10" version="1">MLRVYPVEHGCAVDLRSVQLGLVMLPVSRYITPAFGEEIVWGQVSETSFFGSDLASILKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN24</accession>
    <name>D6SN24_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0435</name>
        <name evidence="2" type="ORF">Dthio_PD0722</name>
        <name evidence="3" type="ORF">Dthio_PD3532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0435"/>
    <dbReference type="EnsemblBacteria" id="EFI33120">
        <property type="protein sequence ID" value="EFI33120"/>
        <property type="gene ID" value="Dthio_PD0435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33391">
        <property type="protein sequence ID" value="EFI33391"/>
        <property type="gene ID" value="Dthio_PD0722"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36085">
        <property type="protein sequence ID" value="EFI36085"/>
        <property type="gene ID" value="Dthio_PD3532"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="995276at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="593" mass="68597" checksum="607ECFCCA90F8AD1" modified="2010-08-10" version="1">MLNLGLTYGPFNVYVYTEMATIQKKPSRGRDYWAIVESRRINGKPRPVVLEHLGTAENLLKRLQEGAGPHKVKSYSHGLVAYLLNLIESLDLVQIINRHVPNKQIRDGFTVGGSIVLASMGRICQPTSKRNWYKGWAKRTSLSYLLRMSLAKIDSQHFWDQMDALPSETIPAIEEEIVDTLYEHGLLSMDTLLYDTSNFFTYIASTNERCTLAKRGKNKQRRIDLRQFGLLLLVSRQDQLPIYHRTYQGNLNDKTVFKEHFARFSDRLKRLSGSLEDITVVLDQGNNSKKMLKEVDQTIYFVGALSVHQHRHLVERANLNLQEILIGNKSVPCYKERTTIWGSDLTAVVYISEKLRDGQIRGLEQGLSKLCSELDQLKEAIKMPTQKGKKRTEAGIQKKIDSLISSCVPKGIVEWELTFLQEDAFELQYWIDYDHLEELKKWRFGRRILITNRHHWSTEEIIKAYWGQANIEYVFKNMKNPFHMAWRPQYHWTDQKIEVHGFICLVAFLLVMVAFKHARENAGFSRSPHTLLEKLSEIRLATLIDAPTQKSKGRYRATYQLEEMDPDVKELADAMGIAELPMKSKIPFSVYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN32</accession>
    <name>D6SN32_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3540"/>
    <dbReference type="EnsemblBacteria" id="EFI36093">
        <property type="protein sequence ID" value="EFI36093"/>
        <property type="gene ID" value="Dthio_PD3540"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XN2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="219" mass="24939" checksum="D43CD2E817A62A58" modified="2010-08-10" version="1">MSQENIGISIHQSVKMIEQAGREIDSLSELIQREIENSISSDLPNLCKVVESWSENLSERNDDYGWVLTDYAFSLGLGQIRKGTPTTARWLGIQISLAGDGMCSEVVKNEQPLVHINLWDHPVSFDEEIYMGPELESTDVQLIDNVLFDWTSEEKFWQDKVWTYSLFLTSLNTIEDIRKKIVQPVTELMKGASPEQAGLTEIEGVVRYNKIVENHYDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN61</accession>
    <name>D6SN61_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0453</name>
        <name evidence="8" type="ORF">Dthio_PD1536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869517.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0453"/>
    <dbReference type="EnsemblBacteria" id="EFI33135">
        <property type="protein sequence ID" value="EFI33135"/>
        <property type="gene ID" value="Dthio_PD0453"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34187">
        <property type="protein sequence ID" value="EFI34187"/>
        <property type="gene ID" value="Dthio_PD1536"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1335357at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="209"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI33135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="394" mass="45845" checksum="FAB209670FB43575" modified="2010-08-10" version="1">MLDRQIQDYLEWMNNAGYAPWTMAQHSQILNRLLDFVVLNSIPWERTFARDTLQAFKDHVQVKYAGFVLRGFMRYLHQNGIICLPPGALPEGRGRSKLQRAQLPRLYEEYLQFYTQTRQVGHVQIYRVRGTLSALNDYLQNQGMELKDLDVLHMDAFLAERNRKYAPETRIHERSGLRGFLRYLYLERQILKKDLSALIQGPPVYAQSRPPRFLTLEQIKTLFQSIDKDRPGGLRSYAMIHLAYSLGLRPGEICRVTLDDILFRDKLIYLPDRKNSSPAKLPLPQGALRALAAYLAWNRPMDPGHRFLLCNTRTPYGPLTPLTVSQNISACFRRAGIKGSAYWLRHTYAQNLLQAEASIFEIKEMLGHDIIKTSKRYLHVHTRLMREVLFNEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN85</accession>
    <name>D6SN85_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869539.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1562"/>
    <dbReference type="EnsemblBacteria" id="EFI34211">
        <property type="protein sequence ID" value="EFI34211"/>
        <property type="gene ID" value="Dthio_PD1562"/>
    </dbReference>
    <dbReference type="OrthoDB" id="489066at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="555" mass="61078" checksum="F1BC602B61EEC0A0" modified="2010-08-10" version="1">MKVLFKSIAEETQTFGELVEVVDAGWVQLWTGSDHEGRLVDTAGISEIGNGWIRTEDLHDLKLDFAQYGHTELWVRPAAADAGTGSWQGSEVDFSTATSQYRTSAVGPETSLHEMFTARNLTEEYWFRVLLRTEQEGQAHWEPFGNDGGWLREDELHEHGISLGDIKESDSASIWVQTYNGNQFLDWVSWDVGGTFIELTEGVDFLAPAHEMPQDKEDDKNYLELSDEDYVIQGEVLRSADGETTLNPDDFIHGGGGENTLYIARMTTDFEGFSNSGGVTDISSIIIHADNRDVAFDATGVQDAEHYTLKTEGQQVDLYNLERGITITTDYTGDMTFEFLAGPDEEDNDHLTLLSTQALGEEGDPAVLRVGSIAELNLEILKAGYLSLEETPDVKSLHLKMGDSLFLEDVPQLEEISVSGRGDLELPWVEGDLEIVDAGELEGEMEVDLSGVEQDSLTRIQGSQKDTTVVADPESFAQGAELDGGEGSNTLILTQAESFMEISISNFQNLIIADQEEDSGVYGELDSATQGHEEPVLDVLGVSRYSEIPDPDTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SN88</accession>
    <name>D6SN88_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869542.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1565"/>
    <dbReference type="EnsemblBacteria" id="EFI34214">
        <property type="protein sequence ID" value="EFI34214"/>
        <property type="gene ID" value="Dthio_PD1565"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="274" mass="30644" checksum="E79378307E1591FC" modified="2010-08-10" version="1">MHFTVLGASGFIGRALLAGIRGQGYQVLAPGREEISRWPDALRDMDLGHVIYCIGVTADFRTRPLDAVEAHVCVLKRLLKSGRFTSLTYLSSVRVYAYAGSTREDSELWVRPDSLDALYNLSKLMGESACLQGSKRARVVRLSHVYGFDPASPDFLSSVLQDAARTGKVTFRTSPDSAKDYISLKDVVELLPLIARDGQYGIYNLACGMNLSNQELADMLRDQGIEVEFASRVARWTFPRIDISRLKSQFYSPGRTLARDLPGLLNEYRRFYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNG1</accession>
    <name>D6SNG1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-bound metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869615.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1638"/>
    <dbReference type="EnsemblBacteria" id="EFI34287">
        <property type="protein sequence ID" value="EFI34287"/>
        <property type="gene ID" value="Dthio_PD1638"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032UI7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1868140at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="150" mass="16829" checksum="91FA7F97DE80A8E9" modified="2010-08-10" version="1">MPGYKGHIAGAVILGAGALAAVNWLAWFRPEPWQALVLMGCVVLGALFPDVDTDSRGQKFFYSLLLIINLTLMVLGYYRWAAILGFLAMLPVVARHRGFIHTWWAMLAIPLAVFLLPVIFYSVAWQVLLPYYLASVFGYFTHLVLDRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNI7</accession>
    <name>D6SNI7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869641.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1664"/>
    <dbReference type="EnsemblBacteria" id="EFI34313">
        <property type="protein sequence ID" value="EFI34313"/>
        <property type="gene ID" value="Dthio_PD1664"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="216"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="461"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="615"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="4">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="714" mass="79713" checksum="903C19D06CAFD872" modified="2010-08-10" version="1">MTDHLEQRIRFLEEQVNYLTQEKRAAMQALELAASMSNFETSLNQVDTPDMILREAADRLKKLIAFKSLCFFLVDEQDSSFYPGYCEPQECLETISTEMQVLVDDKTFAWALGRNKPVVVTALSGDQLMLHAMKTSSRTRGIFFGVLDVEYKEVMDSIQMLATIIFMSVAGALESFELYRNIRQMNNQLTQSNAELRTAKEAALEASRAKSEFLANMSHELRTPISSIISGLKLLAPMEEDPQKLSILNTCKDSAEALHSIINDSLDLAKIEAGKIELIPENFDLHHELAKNLNTFRPQAGTKGLDLRLQMDPGLPRLVRADMHRLGQILRNLLSNAVKFTREGWVELGAEVLIKNEKSCGVNFWVQDTGIGIPKDVLPRLFEAYAQADGSYSKKYGGTGLGLAITRYLVRLMGGSISVHSKEGEGSCFTLNITFELPPEGQAEEVQDPDAEEQTPPEPLNILVAEDQDLPRMYVRHILEQAGHRVIEAHDGIQAVEEALNNPLDLVLMDIQMPGMDGIQASRRIRDALAPQKPAIIALTAYAMQTDRQNFLDAGMDDHLSKPVHPKLLLAKVNALAGSAAAESSLSSGNQDPLQDLQKNGPVNMDLVQEMFEDSRFWLHLVQLFTTQEQPAHIARLDEVLQARDAQRMKRLAHTLKGTMSTLCAERARDLAQSLEKNAGLENWAGIEQDCQALKEELQRMKTFAQKTDIQGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNN8</accession>
    <name>D6SNN8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyl-viologen-reducing hydrogenase delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869692.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1715"/>
    <dbReference type="EnsemblBacteria" id="EFI34364">
        <property type="protein sequence ID" value="EFI34364"/>
        <property type="gene ID" value="Dthio_PD1715"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1769704at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003813">
        <property type="entry name" value="MvhD/FlpD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02662">
        <property type="entry name" value="FlpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlpD" evidence="2">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="137" mass="15226" checksum="184CA6C90CB87373" modified="2010-08-10" version="1">MSFSPNIVGFACQWCTYAGADLAGNLRCKYPPTIKLIRVPCSGSVEPEYVLESLARGADGVLIGGCHYGDCHYKEGNYKTSRRMTILKKMIEDAGFDPKRFRLEWISGAEGKRFAEVVEEFTRELQELGPNPVKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNV1</accession>
    <name>D6SNV1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34427">
        <property type="protein sequence ID" value="EFI34427"/>
        <property type="gene ID" value="Dthio_PD1785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088124" evidence="2">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="65" mass="7093" checksum="304268B7688389D3" modified="2010-08-10" version="1">MKSLYLLFALLLALVLFFGTAGCEDPTENEPQPQAEEPAPETPERADPDPETMPAPEIPDPVNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNX3</accession>
    <name>D6SNX3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recA</name>
        <name evidence="13" type="ORF">Dthio_PD1808</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869771.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1808"/>
    <dbReference type="EnsemblBacteria" id="EFI34449">
        <property type="protein sequence ID" value="EFI34449"/>
        <property type="gene ID" value="Dthio_PD1808"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="11">
        <location>
            <begin position="42"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="12">
        <location>
            <begin position="207"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI34449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="354" mass="38271" checksum="2AA0223B7D7AFAE5" modified="2010-08-10" version="1">MAKKTQSAEDVRKEALQTAITTIERKYGQGSVMRLSDEAHQAIPSIPTGSIGLDLALGIGGIPRGRVSEIYGPESSGKTTLALHVIAEAQKKGGAAAFIDAEHALDVNYAKRLGVKTEELLVSQPDYGEQALEIADLLVRSGGLDVIVVDSVAALIPQAELEGSMGESQVGGQARLMSHAMRKLTGTIHRSKTSLVFINQIRMKIGSMGYGSPETTSGGNALKFYASVRLDIRKIQTLKDKDEVVGNRVKVKTVKNKVAPPFRETQFDILYGQGISRAGELLDMGVEHGVVDKSGAWFAFGSERLGQGRENVRSFLQDNDEIRKNIENQLLTQLGVVQPEEEAQQGQSDSQDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNZ8</accession>
    <name>D6SNZ8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ApbE family lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869796.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1833"/>
    <dbReference type="EnsemblBacteria" id="EFI34474">
        <property type="protein sequence ID" value="EFI34474"/>
        <property type="gene ID" value="Dthio_PD1833"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1979718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="244" mass="25864" checksum="8D23804F5E06759F" modified="2010-08-10" version="1">MHINTHRAYRGFCSPGPGENSFQVVLEQSDLYITSAQDLSAPALDRLQLVRGRILAYSQFNPDFLTSLSPLPVDNQAPDIVQEMARAGGLFQVGPMAAVAGAIAQDIADFLAVRSPEIIIENGGDIYLYSKRTRTIGLLPHPDRSMSLGLVIPETGFPCAVCSSSATVGHSLSLGHGDLVTIKAKNGAVADAAATALCNLIRDRKSLSGLRKTADKFLGTHISGVLAQMGEDMMVVGDMELAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP40</accession>
    <name>D6SP40_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869837.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1882"/>
    <dbReference type="EnsemblBacteria" id="EFI34516">
        <property type="protein sequence ID" value="EFI34516"/>
        <property type="gene ID" value="Dthio_PD1882"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="69"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="262" mass="29261" checksum="6A245BBADB4FC40A" modified="2010-08-10" version="1">MTNLSRLIFCIIICLAVLLLTALPAWTEEMPEDVLDGFKRAHPDMAPEVSPEIEQKSPEVLKRIESDLSKVALTFDACSTWQKTGYDPDVIKILKKTETPATLFLGGLWMLNYSQETEALHDNNLFELGNHSYSHPDLTRHDPSVIRQELGYTQLIARKLTGEMPRLFRPPYVKKNNDVVDIAGELGMLTVQYDIASGDADENASPKEIADYVIDSVRPGSIVILHMNNPDLPTAEALPRIIAGLELRGLKPVTVSELKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP64</accession>
    <name>D6SP64_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IMP cyclohydrolase</fullName>
            <ecNumber evidence="1">3.5.4.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.10" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869860.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1912"/>
    <dbReference type="EnsemblBacteria" id="EFI34540">
        <property type="protein sequence ID" value="EFI34540"/>
        <property type="gene ID" value="Dthio_PD1912"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="424" mass="46911" checksum="2EBAD7D39BFD12AF" modified="2010-08-10" version="1">MQDLRKMYKDIKEDPFPREMSIRLGDQEIRMRKRTWVVQDQEKGLRYGENPDQAAAMYEPVGGGLELGGVKFKGAGQGLVSAITEDDMLQAGKHPGKINLTDVDNGINVLQYLHKKPAAVILKHNNPCGAAWSSEGVLDILQKAYYSDRIAAFGGAVVLNRPIDLAGAEFLADNYLEVVAAPDFEPGALDRLKTRKNLRIIKMAGLGRLQEFADYPFLDIKSMQDGGVIVQFSFTSRMREPEDFIPAQAQGKDQVVSARHPDQRETEDLLFAWAVEAGVTSNSVLFARDGRTLSIGTGEQDRVGCVDLTIHKAYTKYMDMEIFKQTGQSIYQAREKARTDPEAKDLLSSVEEKALKERADLPGAVMVSDGFFPFRDGVDLALEQGITAIAQPGGSMRDHEVIQALNEAQPQAAMVFTGQRSFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP70</accession>
    <name>D6SP70_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD1918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869866.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1918"/>
    <dbReference type="EnsemblBacteria" id="EFI34546">
        <property type="protein sequence ID" value="EFI34546"/>
        <property type="gene ID" value="Dthio_PD1918"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="814704at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="508" mass="58791" checksum="0C3ECE43A9B240CA" modified="2010-08-10" version="1">MKRLNGILLHISSLPGPYGSGDMGPHAYRFVDFLAGSRQKIWQILPLNPTTPGTGNSPYSSYSAFAGNPLFIDPEALQDKGLLDPQDTRDLPGFPEHRTDYELAGDFKKSLLQKAFKRNRESLENGSKFELFCRNHSFWLDDFALFSALKEHFSGAPWYRWPRKIRLRHLEAVEEFKNRLSNEILREKFCQYLFFSQWQKLKTYANNHNVLIFGDLPIYVSLDSCDVWSNPHLFLLDQEKNPTRVAGAPPDYFSETGQLWGNPIYDWEECARENYQWWIKRIRQNLVMFDLLRFDHFRGFASYWSIPAGAQTAVDGKWEEGPGHRFWSALTSEISPAHFVAEDLGYITEDVLELRDSYGLPGMKILQFAFGEDMPTNPYIPHNHIPNCVIYPGTHDNNTVRGWFENELDSIAKKRLSEYTGRRLDAENICREIIRMAMSSPARLCVLPMQDVLGLDGRFRMNTPSVARGNWEWRVKSAEIGIDIKEFLLYFTTIYGRDNHFDAGTNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPN4</accession>
    <name>D6SPN4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD2083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase IS21/IS408/IS1162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870029.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2083"/>
    <dbReference type="EnsemblBacteria" id="EFI34710">
        <property type="protein sequence ID" value="EFI34710"/>
        <property type="gene ID" value="Dthio_PD2083"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="362657at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="111"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI34710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="491" mass="56647" checksum="E9AA87642301C808" modified="2010-08-10" version="1">MIDYELYARIKHYHEQKGLTPAQIAKELQLDPRTVGKWLEAKQFHQRKSVTRPSKLDPFKDTIVRMLEEHPYTAVQVLRSIKEQGYTGGSSILKEYISKVRPKRSRAFLSLAFAPGECAQVDWGNHGSIQVGDSRRNLSFFVMVLCYSRMMYLEFTVSQSMEHFLACHQNAFDAFGAVPRKIMVDNLKCAVLKHPYGQKPVLNPKYLDFAKHWGFEISACGVRKPHEKGRVENAIGYVKKNLLAGLELPDYRAINHYARHWCRATANVRIHAQTGKKPVDMLEEEREHLLPLPVNTYDIGVLTQVRASSQFRITLESNRYSVPARYAGKRLTLKTYPDRLCIYDGNNLVARHVRSFDKKRDIEDPDHVQELIAQRRAARDQQLFSRFLALSPRAKDYFFELEKKHLNIKHHVQKIVALSEIYGSEAVSRAMDDAFTYSAFSCEYVANILEQRARTMPAPGALHLTRREDLLDIEVKDPDLSIYDKPKEKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPS1</accession>
    <name>D6SPS1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870065.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2120"/>
    <dbReference type="EnsemblBacteria" id="EFI34747">
        <property type="protein sequence ID" value="EFI34747"/>
        <property type="gene ID" value="Dthio_PD2120"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZKHR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1569985at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="344" mass="39488" checksum="E788B2E2397C609F" modified="2010-08-10" version="1">MIELRDNTLRFSFPDVHGSASLSINFQKTLRVPDDDKEYPLPPGLGSFPIEHVDDHLHNLPEKWKERGGVMLPMYQSEAMWINFNSTYLYDHQTDYPFAVKIAAGKINAVTGEQWSNGLSRNPQDYMVIPDQPWLDGYCVEKGFIRQFVAMPLGDGYSAEEQITKSAETGGLQIEVYPMKRSAFEKRFPIIQRDERHYVLDESSVSYCLSAPPDMSLAPGGKMRQEIYEDELDMSEWDLNRSARCFVHLTNSEVWKAITGKNPPSLPLTARDYSDYGMPWFEYYSDSKPLPGAEILGKLKSITEMGKTRRIDPLPENESADPQNIVHIRKNMHKNQVREWRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPS8</accession>
    <name>D6SPS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870072.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2130"/>
    <dbReference type="EnsemblBacteria" id="EFI34754">
        <property type="protein sequence ID" value="EFI34754"/>
        <property type="gene ID" value="Dthio_PD2130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="482" mass="56413" checksum="B8170B12162BB3AA" modified="2010-08-10" version="1">MDFKSLGQELIVRWTSDSSLFSRVRSVWNWNLPLTMYYHPDRARQEELDICLKKARIICGGFLQICPYNGSYERVLLRKVQQRLKHSFFKYKRRYVVRMFAEVVILNAFAKRSDYFADWEKLFVDTLDIEYLQGTWEYKVRKEIYNWIFDSSKCLLKSDMDSINFSENSRDWPEAVSRFADSIQKFIQSIEDKNKKVLKSCKIETRGSSSHAKSEKIKKELQTETLEWMNNIQKLESTAMRTYKKGRALKKSHFQPLTDEPWVPGAELNWLRPVLVPWEPYFFPSTPDMHIDIPEKKEQDPRLVLILDKSGSMLEMSQSRLYYSILETCIRAFAEIPFTNAAAVNFARNFHSSGWLDKGSYQLLQKHILSMPDPEESNFPGEEILELVRSETSEREETVCIIFSDGIWLNKSKELSAFFEGISKEKGLEMGMIVPETAGQESTAVNLARKNGLYVRRLVNPELCTSVFEELYQSMSRERAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPU6</accession>
    <name>D6SPU6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Uridine phosphorylase</fullName>
            <ecNumber evidence="5 10">2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD2148</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="5 10"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870088.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2148"/>
    <dbReference type="EnsemblBacteria" id="EFI34772">
        <property type="protein sequence ID" value="EFI34772"/>
        <property type="gene ID" value="Dthio_PD2148"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010058">
        <property type="entry name" value="Uridine_phosphorylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01718">
        <property type="entry name" value="Uridine-psphlse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_UDP_1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI34772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="258" mass="28224" checksum="C8790C86539F2C5F" modified="2010-08-10" version="1">MPDKVYHLGMNREDVRAAQAAILPGDPGRVEDIAGTPTFEYSKEVACKREYRSWLGYLEGRPVLVTSTGIGGPSTSIAIEELAMLGIRHFIRVGTTGAIRDHISPGDVIITTGAVRQDGASTHYAPLEYPAVAHHEAVQSLVQAAQELEINYHVGITCSSDTFYPGQERVDSFSGYVPRRFQGATQEWERLNVLNYEMEAATVLTMCSVLGLVGGCVTGVIVNRHQKEHISQDDLVLGENNAVQTAVRAMQILTREKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPV0</accession>
    <name>D6SPV0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870092.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2152"/>
    <dbReference type="EnsemblBacteria" id="EFI34776">
        <property type="protein sequence ID" value="EFI34776"/>
        <property type="gene ID" value="Dthio_PD2152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="65" mass="8075" checksum="B369E3A770D028C4" modified="2010-08-10" version="1">MSKEKNYWRDEFPGELVLLGIIGGIYYLSNLFKKEEHPEYNRRMDEFWRRKDLNIHPFSINKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ02</accession>
    <name>D6SQ02_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870142.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2218"/>
    <dbReference type="EnsemblBacteria" id="EFI34828">
        <property type="protein sequence ID" value="EFI34828"/>
        <property type="gene ID" value="Dthio_PD2218"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="112" mass="13346" checksum="5EAFCB663B4E12D7" modified="2010-08-10" version="1">MSSKRIRDPLYGFIEVDDQDIKLIDHRLTQRLRWVNQLPLPVFERRVQQDLLVQQDSGKEAPVAEYLGFKISDEDVLEKGDTYLHIFIRPYSSIRHDELRLKIDNVLHRFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ41</accession>
    <name>D6SQ41_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-L-glycero-D-manno-heptose-6-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ADP-L-glycero-beta-D-manno-heptose-6-epimerase</fullName>
            <shortName evidence="3">ADP-glyceromanno-heptose 6-epimerase</shortName>
            <shortName evidence="3">ADP-hep 6-epimerase</shortName>
            <shortName evidence="3">AGME</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hldD</name>
        <name evidence="5" type="ORF">Dthio_PD2258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose</text>
            <dbReference type="Rhea" id="RHEA:17577"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61506"/>
            <dbReference type="EC" id="5.1.3.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
        <text evidence="3">Binds 1 NADP(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.20" evidence="3"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870181.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2258"/>
    <dbReference type="EnsemblBacteria" id="EFI34867">
        <property type="protein sequence ID" value="EFI34867"/>
        <property type="gene ID" value="Dthio_PD2258"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008712">
        <property type="term" value="F:ADP-glyceromanno-heptose 6-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05248">
        <property type="entry name" value="ADP_GME_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01601">
        <property type="entry name" value="Heptose_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011912">
        <property type="entry name" value="Heptose_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02197">
        <property type="entry name" value="heptose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="32"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="74"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="215"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="330" mass="38388" checksum="0ACDD2A2B20BA8D0" modified="2010-08-10" version="1">MYIVTGGAGFIGSGFVWKLNSMGIENILIVDRLGHKEKWKNLVNLRFQNFEHKDSFLDRLENGDFGRVEAIIHMGACSSTTESDADYLMHNNFSYSQRLARYCISSGSRFIYASSAATYGDGSRGFSDDPEIMPDLQPLNMYGYSKQLFDLWMHRQNWLDRAVGLKFFNVYGPNEYHKEDMQSVVRKAYFQVKQTGRVRLFKSYHPDYRHGEQKRDFIYLKDCLEAMAWLLEHQEVNGVFNLGSGRAESWNDLAGAVFKALGRETDIEYIDMPEEIRPKYQYFTRARMHRLEATGCPVRFSSLEEGVHDYILNHLEQDDPYLSLRPVEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ69</accession>
    <name>D6SQ69_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD2286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870209.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2286"/>
    <dbReference type="EnsemblBacteria" id="EFI34895">
        <property type="protein sequence ID" value="EFI34895"/>
        <property type="gene ID" value="Dthio_PD2286"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1213919at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="289" mass="32799" checksum="45AC68BFB53173BD" modified="2010-08-10" version="1">MINKAYISLLRPHQYIKNLFVFAPLFFSFRFLEAEPLLRTFTAFAAFCLIASSVYIFNDIKDINEDSRHPVKKFRPLPGGLVSIPEAYTCMAVLLIAGLGLGLVLDWRIFFILAGYSLLNTFYTLKLKHVAVLDVFIIGIGFVLRIFAGAVAATVQASMWIVLMTFLLALFLALAKRRDDVLLSDEGRDVRKCIDGYNLEFVNVSMIIMAAVTLVSYILYTISPEVQDRFESRHLYLSAVFVLLGIMRYLQIVFVQQGGGNPTRVMLEDRFMQVTVACWLLFFLILTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQH5</accession>
    <name>D6SQH5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpmE</name>
        <name evidence="9" type="ORF">Dthio_PD2393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870315.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2393"/>
    <dbReference type="EnsemblBacteria" id="EFI35001">
        <property type="protein sequence ID" value="EFI35001"/>
        <property type="gene ID" value="Dthio_PD2393"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="69" mass="7849" checksum="F487148EEC2FE218" modified="2010-08-10" version="1">MKKDLHPTLHETKIQCACGNEFQSKSTAGQEITVEVCSQCHPFFTGQQRFVDSAGRIDRFKRKYGQTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQH7</accession>
    <name>D6SQH7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="9" type="ORF">Dthio_PD2395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2395"/>
    <dbReference type="EnsemblBacteria" id="EFI35003">
        <property type="protein sequence ID" value="EFI35003"/>
        <property type="gene ID" value="Dthio_PD2395"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="98"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI35003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="279" mass="31062" checksum="9A6603337721E36C" modified="2010-08-10" version="1">MNTIASMLARGTDELRRAGVDSPGLSARVLLAHALDLSTEKLVLVFQDQTSDEIRRHYEELIARRSRGEPVAYILGRKEFYSLDFQVSPQVLIPRPETELLVELVGNSYSRQQKKIFADLGTGSGILGICIALDFSLFLCLACDISKQALAVARSNARRHRVSDRILFFRGDMGAGIKPQSLDFIVCNPPYISVREFAGLEAEVRNFEPGQALLSGERGLGHIKRLEQEAARLLRGSGRVFLEMGSTQADHVRRIFSRWSSCHIYQDLAGLDRAAVVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQJ0</accession>
    <name>D6SQJ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH/Ubiquinone/plastoquinone (Complex I)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870330.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2409"/>
    <dbReference type="EnsemblBacteria" id="EFI35016">
        <property type="protein sequence ID" value="EFI35016"/>
        <property type="gene ID" value="Dthio_PD2409"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="133"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="493" mass="53649" checksum="710E1AA2F6CBEB90" modified="2010-08-10" version="1">MVDTLQHWGVLIPLIITFLTPIGIYLARHNINVREGVSFLGGILTFASVLALVPGVLEGEVYDYTLLVLMEGIKIRISVDGLSLIFALVASFLWIFATSYNIGYMRSLKEHAQTRYYICFAVAIFGAVGVAFSGNLFTLYLFYEVITFCTCPLVAHHEDDEAYLGMRKYVIYLLGASKLFLFPALILTYFMVGHLDFNMTDISTGIFPEDANTTVVTIIYILFIAGIAKAALIPFHNWLPSAMVAPTPVSGLLHAVAVVKAGVFCISRVILSIFGLDTMDALYLGIPTAYLAAFTIVTASVIAMTKDDLKARLAYSTVSQLSYVIIGIAMINTLSIAGGTMHIAHHAFSKITLFFAAGAIYVATKQKKISNLGGIGRRMPWTFGAFSLAALSMIGVPPVSGFISKWYLLLGSLETGHLVLLGALLASTLLNAYYFGEIIYRAFFGAPAPGVDLNKYSEAPLFMVVPIVAAAVISVLLGIFPETFYQFSQILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQP1</accession>
    <name>D6SQP1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870381.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2461"/>
    <dbReference type="EnsemblBacteria" id="EFI35067">
        <property type="protein sequence ID" value="EFI35067"/>
        <property type="gene ID" value="Dthio_PD2461"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="288" mass="32075" checksum="405241BE9D3A34BD" modified="2010-08-10" version="1">MFDDFLDLEGSGGDNIVHVWPVPYQGTVSFDTGTKDGPEALFKASYQIEPYDPELDADISDYCSFKTLPFQRPVVSGPGQLQQEMDFFLEKFDPCRDFILTLGGEHSIAFPLIRFYSRAYPDLTVLQVDAHADLRSDFQGSPYSHACVMSRVRDLGLKTASLGIRSMDRDQAQIIKNSPCRIMAMHPWNLPSPAQAAEAVKDFIGSGPVYLTFDADGLDPSIMPGTGTPEPGGLEYTWINDFWKHFWPGPRLVGMDFCELAPRPGSVLSESVGVKCILRVLLSYFRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQQ5</accession>
    <name>D6SQQ5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870395.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2475"/>
    <dbReference type="EnsemblBacteria" id="EFI35081">
        <property type="protein sequence ID" value="EFI35081"/>
        <property type="gene ID" value="Dthio_PD2475"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503415Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1842465at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087926" evidence="3">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="174" mass="19544" checksum="8B578197C18C6CEF" modified="2010-08-10" version="1">MRLAALLFICLTLCAGCGYNFAGMTPVDMPEGVSRLHLDQVNNPTQEAWLEPYVRSNFRDEFSRRADISWVDREQSQAYIEIDIKNYRVSDDLTGAGDLTVRSDVRLDLEVNMYHSRDNELLWSSGSVRGSSSYYLAQDQAPVPGESTPGERQAAQEAVEEALRLATDRLGSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQR9</accession>
    <name>D6SQR9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="5" type="ORF">Dthio_PD2489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870409.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2489"/>
    <dbReference type="EnsemblBacteria" id="EFI35095">
        <property type="protein sequence ID" value="EFI35095"/>
        <property type="gene ID" value="Dthio_PD2489"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="631784at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="352" mass="37808" checksum="BBF3D148EAE61ED8" modified="2010-08-10" version="1">MKPIKPWIAVDAMGGDSGPDIVIPGSLEAARQDNLGLVLVGDQEKIEQALSKQKTGDLQLEVLHAPEVVAMNDKPSEALRRKKNSSIQAAFKSVREKTAHGVVSAGNSGATLACGMFTLGRIKGIERPALASILPTEKKEPLVLVDVGANVECKPYHLIQFGLMADVFARDVLHIKNPRIGVLTIGEEEGKGNKLVLETIKLFRSSSMNFIGNVEGRDFFAGKADVVVCDGFVGNVSLKLMEGLAMSLSRILKAEVKKSLLARLGFLLGIRALKRFGRHIDYAEYGGAPLLGLNGIGIVCHGSSNSKAITNAVLMAGEFVRNRANEHLAEGLGQNQEINMFGRRPQAKNHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQT0</accession>
    <name>D6SQT0_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD2500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870420.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2500"/>
    <dbReference type="EnsemblBacteria" id="EFI35106">
        <property type="protein sequence ID" value="EFI35106"/>
        <property type="gene ID" value="Dthio_PD2500"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="322"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="459" mass="50764" checksum="29855B84DE54EDAC" modified="2010-08-10" version="1">MDICIVGTGYVGLVSAACFAEMGNNVYCVDVNPDVVETLNQGRVHIFEPGLEELVRRNRDQGRLHFTPDIREGLDNSLFVFICVGTPPGEDGRADLGFVRQVARDVGRSMQEYKIVVDKSTVPVGTADMVRELIQSELDSRGLELEFDVVSNPEFLKEGDAVSDFMKPDRVIVGTDNIRTAELLRVLYSPFARSREKMMVMGVRSAEMTKYAANCMLATKISFINEIANICEKVGADIGDVRRGIGSDHRIGYHFIYPGVGFGGSCFPKDVSALISTAHEQEYTPSLLRAVEDVNRSQKKVLARKVQEYFSELGGVQGKTLAMWGLAFKANTDDVREAPALEIIKELTASGMQIKAYDPQAGENAARVLQDNPGVEVVKDQYSVLQGAHALAVVTEWNQFRNPDLKRIKSELEIPVIFDGRNLYPPRMLEEMGFSYFCMGRQPVLNSLAGKAEGQSLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR11</accession>
    <name>D6SR11_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870501.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35187">
        <property type="protein sequence ID" value="EFI35187"/>
        <property type="gene ID" value="Dthio_PD2588"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="95" mass="11292" checksum="C0163BF6F6CD7B20" modified="2010-08-10" version="1">MFIIEDIIWLERIVEKLAWKHAVLPSEVEQALSGKCRIFKKEKDRVEGEHLYNALGKTEAGRYLSVFFIRKLDNRALIVTARDMNNNERRRYANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR31</accession>
    <name>D6SR31_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870513.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0468"/>
    <dbReference type="EnsemblBacteria" id="EFI33147">
        <property type="protein sequence ID" value="EFI33147"/>
        <property type="gene ID" value="Dthio_PD0468"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925819at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="66" mass="7648" checksum="96E1FD216E0A3AE1" modified="2010-08-10" version="1">MRIRVDKETDALYFRLDENKIVESEEVQPGVILDFDANNQVVGMEILNISKKTDKKNLSTMQFETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR52</accession>
    <name>D6SR52_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870526.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0491"/>
    <dbReference type="EnsemblBacteria" id="EFI33168">
        <property type="protein sequence ID" value="EFI33168"/>
        <property type="gene ID" value="Dthio_PD0491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="99" mass="11634" checksum="AAC018CFD0339B78" modified="2010-08-10" version="1">MKNTIAKKPVSIRLADDVHQRLEQEARSSHESLTNVITKKLLRETEIEDVIFRIIEHSQNLHKSNWSQVSEILKELIKTHNNLIKEVKGLRKYLENKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR92</accession>
    <name>D6SR92_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870566.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0534"/>
    <dbReference type="EnsemblBacteria" id="EFI33208">
        <property type="protein sequence ID" value="EFI33208"/>
        <property type="gene ID" value="Dthio_PD0534"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="46"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="220"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="429" mass="48328" checksum="8113D1F4544A0F4F" modified="2010-08-10" version="1">MDEHTYRVLLGLNPWIRDASAWPGCAGKYIPTDYIPRSKKINPVEDRVCLLTGPRQAGKSTLIWKTIQEDSKPWMYINCEEQSLKELCSSPALFFQEMEHLASQARGWFFDEIQHLQEAGLFLKGLADLRTRKAIIATGSSSFHLHARTRESLAGRAERHLLLPLSLSEVLPGHVPETVRLMEGKSLWEKLLVWGGYPEVFRSTERESVLARLVEAFVLRDASDIYRIRNPEAFRKLLGLAASMSGNSVNYSNLADSLGVSVNTVSQYLNILEENHIIRLLPPYIGGKRAEITSRPKIFFLDNGLRNFLFGGFQSLHNRSDAGAVMENMVFCELSKYMHPILDGLNFWRSSSGAEVDFVLQKGQKIIAVEVKSSNIKKPKISRSLRSFIQAYRPDQVLVVNQGLTHSTRVDGVNVSFLVPPEFPLVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR93</accession>
    <name>D6SR93_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870567.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0535"/>
    <dbReference type="EnsemblBacteria" id="EFI33209">
        <property type="protein sequence ID" value="EFI33209"/>
        <property type="gene ID" value="Dthio_PD0535"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="144811at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="789" mass="86144" checksum="A8BEB0F9D35F042F" modified="2010-08-10" version="1">MQEAETIRLKGRDDSGRVSSRVLEERIQEAVRQGASTIEIEAFGQHGLGGRIFKPGGENTRVLITGSSGQRAGSMGFSGTEIQIMGPASDDIGWLNAGADIVVHGHATNGTCNAMAQGRVFVAGNIGSRGMTMTKFNPRFEPPELWVLGSAGDYFAEFMAGGVAVICGHNPQDPASVLGYRPCVGMVGGKIFFRGPVEGYSQADARLEPISDEMWEWFAASLRIFLQKINRESLYDKLCVRQDWQCLVARTPMEKVGARRRSMAQFRAQIWDEELGRGGLIGDLTDLDRSQIPLITTGDLRRYVPVWEHRKYMAPCQWACPTGMPVQERWRLIREGKVDEAVDVALAFTPFPASICGYLCPNLCMQGCTKTTSNLQPVDITCLGREGTRSRVPDLPDLSGSRVAVIGGGAAGISVAWQLRLKGHDAVIFDLEKVLGGKMSTAIPENRIPAEILDAELERVRKVLAHVHLQQKLTRSEFEQLKSDFDYVVVAVGARTPRTIPIPGSDRIIPALTFLKNARQGTQEVGERLVIIGAGNVGCDVATEAHRLGAREITLIDIQEPASFGKERREAEHAGAKFRYPCFTKEVTAQGVVLTSGEVIPADTVVISIGDMPDLEFLPESISTRQGFVLVDEENRTSDPQVFAIGDIVKPGLLTDAIGAGRKAAQTIDALLTGKRPDQGKSWLERFDVEYSESSERIDYSRMTQEYYDPRITQFEGLNGCAEQCSSCGSCMDCGLCDAVCPTGAIERTDLPQGKFQRAADPEKCIGCGFCGKCCPCGIWDLVENFPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR95</accession>
    <name>D6SR95_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870569.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0537"/>
    <dbReference type="EnsemblBacteria" id="EFI33211">
        <property type="protein sequence ID" value="EFI33211"/>
        <property type="gene ID" value="Dthio_PD0537"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="453671at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="376" mass="42374" checksum="A45483D3F3F3731B" modified="2010-08-10" version="1">MCRLFSLTSTSCVSPMKAIEALDMMKEGHDGSGVGLFLSSLEGPFSRYKGLPILSGIFTRNGFKRMEEYMAELGFIPRFQLTLDTTGNPPPGTPRREIYLIQVFDPPEEFKSLEPVLQERKLTETRLNLRHMGQEKEDMVVFSFWPDVITIKEVGDPLETGQYLGLDREELCARQILAQGRQNTNYGINLYACHPFFIQGVSSMTNGENTAFVPIKEYLSTQGVVGYEGYQSDSEVFTHILHFTLKEMGLGIEAYKHVITPLQGSDLEAHPDREFLQRLKQACRRLIIDGPNCVIGCLPDKTMFMVQDRKKLRPGIVGGRPGLYAFSSEACGLDAVIPDRDKSLDFQPMHLDTAIVSPECKEVRICRQTQPLPLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRF3</accession>
    <name>D6SRF3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870627.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0595"/>
    <dbReference type="EnsemblBacteria" id="EFI33269">
        <property type="protein sequence ID" value="EFI33269"/>
        <property type="gene ID" value="Dthio_PD0595"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667096at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088040" evidence="1">
        <location>
            <begin position="24"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="209" mass="24084" checksum="80320F2C9832E57E" modified="2010-08-10" version="1">MKKQLLFCLLLVFAWHLHPALVAAEQDQDGQARQEKKWSLTLSSGMYTDRTVGQAIFNVPGRLESNYMHSLALAREMGRFWDHFSWELEGMFAKHHGKHKTGRQDYEEFVGAILVRYHTFPWDQWIDTTLAVGSGVSATTETPKRELQTDRGKSQNILNYLAFELELTLPRFPDTSLTYRIHHRSGVFGLYGGVEGASDFYLLGLRQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRI2</accession>
    <name>D6SRI2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="9" type="ORF">Dthio_PD0624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870656.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0624"/>
    <dbReference type="EnsemblBacteria" id="EFI33298">
        <property type="protein sequence ID" value="EFI33298"/>
        <property type="gene ID" value="Dthio_PD0624"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="916845at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="266" mass="28436" checksum="85BA8414C169F944" modified="2010-08-10" version="1">MPRMTVPEVIKTKGQRKLTMLTAYESAMARFVDQGGIDMILVGDSLAMVVLGHEDTLSVTMDEMLHHTRAVTRVAGNSLIVADLPFMSYQVSVEEAVINAGRMLKEGRAGAVKVEGGDSILPQIQGMVKAGIPVMGHLGLTPQSIAHFGGFKVQGRGEAGEKIVQEARKLEEAGCFSLVLEAVPPGLASRITSSLNIPTIGIGAGLECDGQVLVINDLLGMSTGPGPRFVKKYADLAGVISEAVERYRREVQNGEFPDESHCYKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRN8</accession>
    <name>D6SRN8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870712.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0682"/>
    <dbReference type="EnsemblBacteria" id="EFI33354">
        <property type="protein sequence ID" value="EFI33354"/>
        <property type="gene ID" value="Dthio_PD0682"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="263"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="391" mass="43090" checksum="A369C63DE545D0D3" modified="2010-08-10" version="1">MSKAIGLEVSLAVAEAVKQANVDVISAYPITPQTHIVEELSVYVANGELDAEYIPVESEHSAMSAAIGSSAAGARSYTATAAQGLAYMHETLFIASGMRLPIVMTVANRALSAPISIWNDHSDIMAERDVGWVQLFGENGQEAYELSIIAFKIAEDHRVLLPAIVNIDGFILTHMIEPVTFLDQAKIDEFLPPFKPALTLNPEKPVTMGPVGVPEVYTESRKQCEQALWNSLEVVREVFDEWKQKFDHEYKLIEKNGDPQGKTLFITMGSQGETTMNAVEDLQAQGESVGQVRIRLWRPFPREDFLQAIKGAEKIIVIDRALSPGAYSGPVAQEILALLYSQETRPRVYNVIAGLGGRDVTVNDFKEMYAQAQKDSLDPNYTIWGVCSDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRP2</accession>
    <name>D6SRP2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SH3 type 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD0686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0686"/>
    <dbReference type="EnsemblBacteria" id="EFI33358">
        <property type="protein sequence ID" value="EFI33358"/>
        <property type="gene ID" value="Dthio_PD0686"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4991">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1707622at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016476">
        <property type="entry name" value="SH3_dom_pro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04211">
        <property type="entry name" value="SH3_and_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="8">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="92"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="221" mass="25759" checksum="B6724F04F65525A2" modified="2010-08-10" version="1">MFFKIIPMILILVFLLCSQVQGRTLYVTDELSITMRTGPSLQHRVVRMLPSGTSFQVLEESGDYYRVRITDGNEGWVLKQYAMDRTPREMVIRQLESNISRLQERLPVSEQKAADLEKENSEVRTKLMTLEQELSELTKRYQTLLEDSGNIDGIKQDLERATRSLEQKEVHIMDLEQENQELRTEKNMYWFLAGGGTIAFTALIGFILGRVQRKQARRFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRU7</accession>
    <name>D6SRU7_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870766.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0745"/>
    <dbReference type="EnsemblBacteria" id="EFI33413">
        <property type="protein sequence ID" value="EFI33413"/>
        <property type="gene ID" value="Dthio_PD0745"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="306" mass="35588" checksum="3B76F2E308AA6DE7" modified="2010-08-10" version="1">MPRIARFIRNDRQTVYHVISRTALPGLPIKDTDKDYLLGLIKRLSRLYFVDVLGFAVMGNHFHLVARMHPEDEISNSDIIKRWQDYYGDKVEMPTDRMAEVKKRLCSLGAYVKDIKQNFTRYYNKKHRRQGFFWGGRFKSMIVQEGSTLVNLLAYVDLNPIRAGIVKKPENYRWSSLGYHTQTGNKDGLLDIDFGLKEWNELDPKEIVRKYRQFVYETGAVDAGKGKTIDQKVVEKARKKGYKISRTDRFRYRCRYFTDSGVIGGKDFVQEVFDQVKHLLGSKDERKFTPVGGVEGLYSMKRLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRW1</accession>
    <name>D6SRW1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870779.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0761"/>
    <dbReference type="EnsemblBacteria" id="EFI33427">
        <property type="protein sequence ID" value="EFI33427"/>
        <property type="gene ID" value="Dthio_PD0761"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033BFW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2045422at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045944">
        <property type="entry name" value="DUF6364"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19891">
        <property type="entry name" value="DUF6364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="80" mass="8972" checksum="64F8F0E3160D23E9" modified="2010-08-10" version="1">MNITLSADKELIQKAREYAAQRGTSLNQLIREYLEYTAAMGDKESSAREFERLARECGGTSPEGYVFDREDAHARGEDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRX4</accession>
    <name>D6SRX4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module toxin, RelE/StbE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870792.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0774"/>
    <dbReference type="EnsemblBacteria" id="EFI33440">
        <property type="protein sequence ID" value="EFI33440"/>
        <property type="gene ID" value="Dthio_PD0774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="91" mass="11206" checksum="E6C4CA3DDF12D810" modified="2010-08-10" version="1">MWTIKYLKSARKDVQKIDPQIRKRVREYLEQRIARLENPRQLGEPLKGQLTKLWRYRVGDYRIVCELRDHELIVVRIGHRKNVYKNYDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRZ7</accession>
    <name>D6SRZ7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870815.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0797"/>
    <dbReference type="EnsemblBacteria" id="EFI33463">
        <property type="protein sequence ID" value="EFI33463"/>
        <property type="gene ID" value="Dthio_PD0797"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="203"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="486" mass="56091" checksum="642DA83746D6FD84" modified="2010-08-10" version="1">MHPVDHSKIVLVHPLGYSSGKSGRDISRMANIMPPLGLCGLASYLEHRGLEADIVDFNARPDSVQRLKDILIHKRPAYIGFSCTTSSFLDGIRLARESKTLLPDIRVVFGGVHVSSLGEEMMHQHAVIDYAVVGEGEETLAQLMQNCGHAPGIPGLIYREPGNREVVFTGRRPLLDDLDELPYPAYEKLEGFPKSYPLPIFNYPKSPNTSAITSRGCPYSCSYCDRSVFQKSYRFNSAEYIYEHMRYLNQHFKVRHINFYDDQFSFKLKRLERLTDMLVNRPLNMSFNCAVRSEHLTESLLKRLKDAGCWMISLGIESGDQDMLHALNRKVNLEKLAERVRLIKKYGIRVKGLLMIGMPGETEASVEKTRQFLFSLPVDDFNLTKFTPFPGAPVYRTIREYGDFQEDWSRMDCMHFLFVPQGFTLQRLEELHRSFYRDHFKRPRVLVDYAAMLWNSPDSWRRFVLNLGSFIRFARSGERFSREKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS13</accession>
    <name>D6SS13_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">All-trans-retinol 13,14-reductase</fullName>
            <ecNumber evidence="1">1.3.99.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.23" evidence="1"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870831.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0813"/>
    <dbReference type="EnsemblBacteria" id="EFI33479">
        <property type="protein sequence ID" value="EFI33479"/>
        <property type="gene ID" value="Dthio_PD0813"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051786">
        <property type="term" value="F:all-trans-retinol 13,14-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="494" mass="55385" checksum="F2A89BD9439AAECA" modified="2010-08-10" version="1">MKYDYVVIGSGISGLVSGIILSKQGLSVAVLEKAAQPAPLLRGFKRRGIHIDTGFHYTGAFAHGEALDSYFRYLNIAEDLEKIPYDSECFDSFYFTDDDYSFSFPFGYERLRDRLCSAFPHEKKGIDSYLHTVSEEFNRSPHLNLDISSNNIFMYDPYSSQSLKSFLQGLISNPRLRSILSMHYLLYGTEPGRSSVSVHAQVAGSLYSSVHGIKGGGRTLAKTLLQRLRNLDADIFSRSNVAKVMVRAGEFQGVELANGETVQAKGCISSIHPRALLPLVEETAFRPATRQRFQAFEDTTSAFMFSAELEQLPEMLSRKNLFLCPDDDLDTYCHLERAIEKRPFFFASAGLENEKSRPGMIMLCPASMQEMYPWRDSLPEHRPESYLEMKQALMQRVHDHVLRKVPAIHSLTMLDCATPLTFRDYANAPSGCLYGIKQKYGQLNPTPLSKIRGLYLTGQALTAPGILGGTISAFLTCGVILGQQKLIQEVRKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS48</accession>
    <name>D6SS48_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0848"/>
    <dbReference type="EnsemblBacteria" id="EFI33514">
        <property type="protein sequence ID" value="EFI33514"/>
        <property type="gene ID" value="Dthio_PD0848"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="120"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="200" mass="22366" checksum="CA2A6FC32E9DC108" modified="2010-08-10" version="1">MAGTRHFKANQMIFQENDPGEGFYGIVQGKVKIYKSSPLGKEHILHIFGPGEIFAEVAVFAGRNFPASALCLEDTKLLFFPRKQFRRLISENPDLGLNLLGLLSMRLRNMVGKVEELSLKEVPARLATHLLLIRENLGKDQFDLDLNKSQLAGFLGTIPETLSRVIRKMNEEEYIETAGKKVTLLDISGLEDLAAGNLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS72</accession>
    <name>D6SS72_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="9">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="9">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">psd</name>
        <name evidence="11" type="ORF">Dthio_PD0872</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="9"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870888.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0872"/>
    <dbReference type="EnsemblBacteria" id="EFI33538">
        <property type="protein sequence ID" value="EFI33538"/>
        <property type="gene ID" value="Dthio_PD0872"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="891720at2"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023411128" description="Phosphatidylserine decarboxylase beta chain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023411129" description="Phosphatidylserine decarboxylase alpha chain" evidence="9">
        <location>
            <begin position="182"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="9">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI33538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="220" mass="24295" checksum="3CBCAA4157526ED9" modified="2010-08-10" version="1">MQKPHFHIRPEGLNIISLTVLVTLVFSLLGWAFFSIIGLVASFFALNFFRDPERVTPDAPGVAVAPADGRVVKVETMQDPFTGEQRTAICIFMNVFNVHVNRFPLTGTVQAINYQPGKFINASLDKASLDNERCALHFEDEDRRGWTMVQIAGLLARRIVCYAETGDKLSRGQRFGLIKLGSRVDLYLPQGYESKVSVGEKTIAGQSIIARKTDSASGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS78</accession>
    <name>D6SS78_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870894.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0878"/>
    <dbReference type="EnsemblBacteria" id="EFI33544">
        <property type="protein sequence ID" value="EFI33544"/>
        <property type="gene ID" value="Dthio_PD0878"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2078260at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="64" mass="7308" checksum="D63FFFDBE3C84523" modified="2010-08-10" version="1">MQILIEPENQWADIDRATTVLNLLKKLELRPNQAIVIRNGELLTPDRQIDPEDSITVRKTASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS98</accession>
    <name>D6SS98_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870914.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0898"/>
    <dbReference type="EnsemblBacteria" id="EFI33564">
        <property type="protein sequence ID" value="EFI33564"/>
        <property type="gene ID" value="Dthio_PD0898"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="75" mass="8521" checksum="F2D221F11C733EA6" modified="2010-08-10" version="1">MRVTTKGQVTIPVNIREKLGITPDTEIDFLQEGDRVFLVKREGTARATRKFKKLRGVATVKMTTDEIMALTRDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSH9</accession>
    <name>D6SSH9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870994.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0981"/>
    <dbReference type="EnsemblBacteria" id="EFI33645">
        <property type="protein sequence ID" value="EFI33645"/>
        <property type="gene ID" value="Dthio_PD0981"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1094814at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021812">
        <property type="entry name" value="DUF3391"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11871">
        <property type="entry name" value="DUF3391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="155"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="431" mass="49567" checksum="3299FED03B02A13C" modified="2010-08-10" version="1">MSSQAAEKVSVDQLQVGVYIQLQEVWYMHPFLRSSFLIKKEKQIQALRDSGIKEVLYVPEKSQRPCLPARKKKPAEPLQNEQEKDTSPDENISGQVWETKQRRIKQFSNIQERIKKCSRQYKNTVQKMPSMLNDIFAGREEGMQNAQEVVSEMAQTFLSETTAVMHLMDAEEADMDLAYHFLNVSVLSMMIGEAAQLQEEDMKHLGMGALLHDLGKLRIEKKHLRKPREMLSKHELKLLKMHPQYGVETLCAIKTGPPQPVKEIVRHHHEALSGIGYPQGLKADRISYLTRITTLANIFDNLCNPYNPEQAMSPHHALSFIYRRYDLILDMHLVSLLVKRLGVYPPGCIVELSTKEVAKVMAVDPAKPLRPLILLYDPDVPRKHAAVFNMDEDRDLFIDRCLNPEELSQEAARYLKPRQKVAYYAEEVPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSJ4</accession>
    <name>D6SSJ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871009.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0996"/>
    <dbReference type="EnsemblBacteria" id="EFI33660">
        <property type="protein sequence ID" value="EFI33660"/>
        <property type="gene ID" value="Dthio_PD0996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1027015at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="38"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="249" mass="27402" checksum="B8FCAE67E9D945DC" modified="2010-08-10" version="1">MKQGGAEDLFPRGLAQPEAGFRFSVDSLLLSVFLVPGNNWKVLDLGCGCGVVGLGLILANPGKEIQVTGVDNDPEMIECARQNSRALCLEEKSSYRLLDVTSLDSQSLAPESFDLVLANPPYRDERSGRTPENPGKKSAQFVTKNSQLDFFQAAFFALKNRAAAGFVYPASRLDQLLLNLDRSRLRPKTILPVYGRAGKQASLVLVKARKNSGPELSMLPPLILYDEHNSLTQQAREFCPFLECNQGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSK1</accession>
    <name>D6SSK1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871016.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1003"/>
    <dbReference type="EnsemblBacteria" id="EFI33667">
        <property type="protein sequence ID" value="EFI33667"/>
        <property type="gene ID" value="Dthio_PD1003"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="27351" checksum="ED21CCBDCBF9A269" modified="2010-08-10" version="1">MNSGIDLSPYFSRYEQLMQGVDSIFHKMKGDFPGEVRCDDGCTDCCYALFDLSLVEALYLNHRFQELDTSLRNMVLVEADKADRRTHKIKKQLFKEHEGGASEEEILKKAGKERVQCPLLMEGKCILYESRPLTCRLYGLPMKIGENTVSCSMSRFEPGVQYPTVDMHKLHEQLLHLSQELAKGIGTKYVELHTVLVPVSMALLTEYDREYLGVEAAQNSCETTSKDQKGPTREWVLGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSR3</accession>
    <name>D6SSR3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871078.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1068"/>
    <dbReference type="EnsemblBacteria" id="EFI33729">
        <property type="protein sequence ID" value="EFI33729"/>
        <property type="gene ID" value="Dthio_PD1068"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1942718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST" evidence="1">
        <location>
            <begin position="28"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="2">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="376" mass="40802" checksum="9A46463F26642A2B" modified="2010-08-10" version="1">MILRVCRKGSVESLQSMLQEVQNHGRVKSILILACDADGFTPENVDPVLQECGLPLLGGIFPQIIAEGENLEKGTIVAGLFYDTVSLYVPGLSDDDRVMDDAVDEALTGVDVEDRTFFVFVDGLSSRISAFIDGLFNNLGLMPNYIGGGAGSLSFEQKPCLFTNLGLKGDGAVVGVSEVRSGIGVAHGWHPITKTMKVTESEKNRVISLNWEPAFQVYQSVIKEQSGLSFDEQPFFDIAKAHPLGIVKLDAEMIVRDPLFTENDELVCVGEVPVNSFVYILRGNMDSLIEGAVQARDIALNNYHGDPNKASMLFMDCISRVLFMGEEFKKELQAADCGLTTFGALTIGEIANTGDAYLEFYNKTAVAGILGDPHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSW8</accession>
    <name>D6SSW8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871133.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1123"/>
    <dbReference type="EnsemblBacteria" id="EFI33784">
        <property type="protein sequence ID" value="EFI33784"/>
        <property type="gene ID" value="Dthio_PD1123"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI33784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="332" mass="36007" checksum="AFEDD5D2C22BFC74" modified="2010-08-10" version="1">MAFKVGINGFGRIGRYMTRLLAGNQELQLVAINARADNQDLAHLFKYDSVHGTFPGEVQANDKGFTVDGNQVLVTRQGPGEWSWGDLGTDMVLETTGKFTDRESNEKHLSCGAKKVLISAPGKNPDNTIVVGVNDKDLRPEDKIISNASCTTNCLAPAARVLHDSFGIKHGLMTTIHSYTMSQRILDGSHKDIRRARAAAMSMIPTTTGAARMVTQVIPELKGKLDGMAVRVPTANVSLVDLVVEVEKKTTAQEVNQALQAASQGAQKDALGYTEVPLVSVDYNGSTYGGVVDGPLTSVMDDTQVKLIIWYDNEAGFCNQLLRLMHKVKAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D6STD3</accession>
    <name>D6STD3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871298.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1288"/>
    <dbReference type="EnsemblBacteria" id="EFI33949">
        <property type="protein sequence ID" value="EFI33949"/>
        <property type="gene ID" value="Dthio_PD1288"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="218"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="358" mass="41034" checksum="6268B6FA870044D9" modified="2010-08-10" version="1">MEANKKKNSTKSITPDELNSTLCRLGVEHRPEWIAVIFFIRNLMSRMNSIELEKKYQLQREVLQVIEKKEFTGENLDRIIRSMEEAFTCNLQDNLGLMEQKLANEQKFTNTLLSQIQLLTDEFRKSVNRQSTDLEDFGEQTVSDIENNKDPGEIIGYIRGTIKEIVTQARKEADSWENKARTLEHYARYDHLLGSLYNRSWFDEKIYSLTEQALENNARLALLMIDVDHFKSINDSWGHQVGDDVLKALAKIIKEHAEVGSGYPCRYGGEELCIIFKDTDEQLAGVQAEELRREVQGYNFIPRKKDGSLGDSINFTVSIGVAELQKDWDAGMLIGAADKALYHAKESGRNRAILFSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6STH5</accession>
    <name>D6STH5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amphi-Trp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871340.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1330"/>
    <dbReference type="EnsemblBacteria" id="EFI33991">
        <property type="protein sequence ID" value="EFI33991"/>
        <property type="gene ID" value="Dthio_PD1330"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503312U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016843at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20068">
        <property type="entry name" value="Amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amphi-Trp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="89" mass="10032" checksum="3F8B4A9772E57257" modified="2010-08-10" version="1">MEVVLFKSEEKKSTQEVAAILRQIADKVESGEVVLTRGQEEVRLQIPPNVTLELKVEEETKRSTKKSLEIEIEWPEGEEGKPRGDVSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6STL1</accession>
    <name>D6STL1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PhoP regulatory network protein YrbL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1366"/>
    <dbReference type="EnsemblBacteria" id="EFI34027">
        <property type="protein sequence ID" value="EFI34027"/>
        <property type="gene ID" value="Dthio_PD1366"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019647">
        <property type="entry name" value="PhoP_reg_network_YrbL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10707">
        <property type="entry name" value="YrbL-PhoP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="134" mass="15418" checksum="86FEE9B20B5D0390" modified="2010-08-10" version="1">MHTVDCLGWVETNMGPAIMLQRVLNQDGSPSMTLKSALEHGLLDWNMVKGMLYELRTWAIQYAVVISELNIKNLMLRTGSDGDRLVVVDGLGGRKPDMVFHLRSRIPWMARHKTLKRWPREYNKVKDAVMNILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6STN6</accession>
    <name>D6STN6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871401.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1391"/>
    <dbReference type="EnsemblBacteria" id="EFI34052">
        <property type="protein sequence ID" value="EFI34052"/>
        <property type="gene ID" value="Dthio_PD1391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087957" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="68" mass="7236" checksum="CA8B589EC723DF07" modified="2010-08-10" version="1">MKKIICITVIYLFLLAAPLNSSEFAMPMPTGSAAQLQSIETQDTRGLADNLSFISAGVVNTLMGMLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6STU5</accession>
    <name>D6STU5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871460.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1452"/>
    <dbReference type="EnsemblBacteria" id="EFI34111">
        <property type="protein sequence ID" value="EFI34111"/>
        <property type="gene ID" value="Dthio_PD1452"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1520143at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="446" mass="50634" checksum="461EE98B5A2DEEDD" modified="2010-08-10" version="1">MSRTLYDILEVSKTAPPEVIKSAYRSLAAIYHPDSGQSPDEDKFKRIVRAYEVLSDPEKRSEYDARILHEEEEKFLGFATDDESLAPKTVKRVDGTDTWCTIDEHIRRKGAELAEADLNGLKLRDLSLKKAQLIGADLSNSDIKNVDLSEANLTGLTCKNSIFENVDFTETKMDHAYFEQCIFKKCKFSGIPTVESPIKHASFISSDISNHNFYHLSFNNVDFSNSILESSSFGITEDNLRSEDHTIINCKMINVNLRMAEFGSNITNVDFSNSNLNNIFCSSIKLVKCNFSNTNLANSKFKESIIKNPISFENSVLYNADLSSSGIINSDFSSCNLINTRFHEAYLIDVIFPVDYKLPDSAISRKSSQEKGGCYIATIIYGDYNDLQVFILRQFRDRYLKKTTMGTYLIKIYYNTAPLLIKYVGHCKLFQVIVKFVLDRLVKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6STV2</accession>
    <name>D6STV2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD1459</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871467.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1459"/>
    <dbReference type="EnsemblBacteria" id="EFI34118">
        <property type="protein sequence ID" value="EFI34118"/>
        <property type="gene ID" value="Dthio_PD1459"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="613860at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="253"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="HD Cas3-type" evidence="11">
        <location>
            <begin position="565"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="781" mass="87971" checksum="7591D7741A0D4F28" modified="2010-08-10" version="1">MYTGFDSFFKRAIGEALDPYPYQVSLSGRDWPDLLGIPTGLGKTASVVLAWLFKRFHSDERTPRRLVYCLPMRVLVEQTAQNARQWITSLKEHGVYDAGKEPTVHVLMGGDLDSSWDMFPEHDQILIGTQDQLLSRALNRGYSMSRYRWPVHFGLMNNDCLWVMDEVQLMGDALATTAQLQAFRDFFKTAYPVRSIWMSATLKKDWLDTVDFSSALDSLETLSLTDEDKKQPAVKQRISASKPIQKAPCQSTDLRKLVDLTLKEHHPGTRTLVVTNTVKRAQALFNELQKKKPSADLVLIHSRFRPGDRKKAMDELLKTPGGEGTICVCTQAIEAGVDVSASVLITELGPWASLIQRFGRCNRDGLEQDARIFWVDIDLDKKGACAPYEAEELARSRQILEKLKDAQPGSLPGLEENPQYLQVIRKKDLVDLFDTTPDLAGMDIDASRFIRDSDEQSLQVFWRLLDENGPKPDEPPPAREELCSVSIGSIASASDLRKWRWDHLEKNWVRVWRNAELFPGAVLFLDVKDGGYSSTLGWTGDKKDLPEVLSKPDKVSEGYDDDFITISTWQSLSDHTEAVVAELKDLIEVLNLSDVKMKEALILAAQWHDCGKAHKIFQEGVTRYAEPPPYNQLWGKTSSSSVSYSRKGFRHELASGLAMMQNNLPDLAVYLVAAHHGKVRLSIRSLPTETRPDQDVRHARGVWDGDVLPEADLGNGVVMPETILDLSVMELGHGKSGSSWLERMIKLRDDPHLGPFRLAYLEALLRIADWRASMNQGSKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6STX2</accession>
    <name>D6STX2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871487.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34138">
        <property type="protein sequence ID" value="EFI34138"/>
        <property type="gene ID" value="Dthio_PD1480"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031KXS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1981116at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="126" mass="14216" checksum="1BEBF1AFFBAC6727" modified="2010-08-10" version="1">MTQPASVIDLYDSLLAAEDERARARIIAGAFERLEDRYPELKDLATASGVRESELRLQKEIEQVRADLSKEIEKVRTELIREIEKLRADTSKEIAFGNQKILRWTTGLLFAQLAAIIAVIFGVGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6STX9</accession>
    <name>D6STX9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1487"/>
    <dbReference type="EnsemblBacteria" id="EFI34145">
        <property type="protein sequence ID" value="EFI34145"/>
        <property type="gene ID" value="Dthio_PD1487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="151" mass="16952" checksum="2E1C8BCF137B1D0F" modified="2010-08-10" version="1">MYDMPREAGSHWNVRPPGLPCQKIPPPSRPYSLFIIHLFFLPHAPCPMHPLPLPYFLPHAPCPMPHAPCLLPPCPMPSSPMPHALCPLPPMPHALCPNPPIPKSPNSPIPKFLNSPIPEYLLDKNIALRLNSLKQTSRRISWTPRKQCSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU41</accession>
    <name>D6SU41_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32821">
        <property type="protein sequence ID" value="EFI32821"/>
        <property type="gene ID" value="Dthio_PD0127"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XZ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2049035at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045397">
        <property type="entry name" value="DUF6516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20126">
        <property type="entry name" value="DUF6516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="125" mass="14241" checksum="4F3FDA58EA64C37C" modified="2010-08-10" version="1">MQIHDYLHEVRSAIERMDLYGFADVIDIQEELRAGKQAVIQASVVLVDGSSLHVREYIDAAYGIKKVSYGYHYQDRHGKLVFRYDNARHKLALQSKEHKHLSDNSIVEAAAPSISELVEEVVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU61</accession>
    <name>D6SU61_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871537.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0148"/>
    <dbReference type="EnsemblBacteria" id="EFI32841">
        <property type="protein sequence ID" value="EFI32841"/>
        <property type="gene ID" value="Dthio_PD0148"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032T51">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1623237at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="185" mass="21530" checksum="46E675941F36AFCD" modified="2010-08-10" version="1">MSMRRVMIVLLCEDSQHESFIRRFLKTMGWDTRQMRIEKSPFARGSAEQWVRRRFPVEIQACRSRRTKASTMLVAMVDGDNKNPDERIRELAVECEQKNISFRDNQEPVAIAVPCRNIETWIRYLDGEQVNEDEVYPKFDHERTCRVAVARLAGLCRAEGLPGDAPSALKLACDEYNRRIRPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU67</accession>
    <name>D6SU67_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871543.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0154"/>
    <dbReference type="EnsemblBacteria" id="EFI32847">
        <property type="protein sequence ID" value="EFI32847"/>
        <property type="gene ID" value="Dthio_PD0154"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1341722at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="297" mass="32736" checksum="12EA74207A7F3532" modified="2010-08-10" version="1">MKSTREFLQKIGLPPGDAYDLPTSARRFPDGGQYRFEVPGIQGPGPMKALLKALNDQGVHIHRVTQTKGIMLLSDEDMQAMVALADDFQVDLVLSIGPRATYDTSASVHTPEGQRMGYRLRGQEQIVRAVEDVKRAVALGCRNFLVYDEGCLWILNEMRKAGEIPADCTFKVSAHCGHGNPCSARLLEIIGADSINPVRDIQLQMLAAMRQAVDIPLDVHTENPASSGGFIRHYEVPEMIRVAAPIYLKTGGSVAKTHSWDTTDADARARAKQVLLVKRMIDAYYPEALCSKFEKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU72</accession>
    <name>D6SU72_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871548.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0159"/>
    <dbReference type="EnsemblBacteria" id="EFI32852">
        <property type="protein sequence ID" value="EFI32852"/>
        <property type="gene ID" value="Dthio_PD0159"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="58"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="293" mass="33477" checksum="B13A8C0C64397533" modified="2010-08-10" version="1">MTEKHRLRSIDPMLSFAYSKDDLPLRDDETVIPGFVIMRSGDRVSVNGLRIMILGGSTSGPYFNGNWPRQFRSMLDREGITATVYNGAVSAYSTNQELLKFIRDGLALRPDLVISLSGVNDLGFMHSIRKHPMHHPYTSFILQSLLRNQVRGKQKGDIINDLNFGPPIETTPADQWERNIRLMNAITSEYGIKYYAFLQPTLGIGDYHPTPQEQQMLEAYIHETNGRYLNDAHEFYESALARIKTCEFVFSLVDIFKSTNNIYYNPRHPNADGYAIIANAVFNRLKHSSFFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU73</accession>
    <name>D6SU73_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe-S type hydro-lyase tartrate/fumarate beta region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0160"/>
    <dbReference type="EnsemblBacteria" id="EFI32853">
        <property type="protein sequence ID" value="EFI32853"/>
        <property type="gene ID" value="Dthio_PD0160"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI32853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="20834" checksum="4216D11FB3D4BB25" modified="2010-08-10" version="1">MLNELIVTYHIITIFENTVLILDKIIVVNNATISELMTNSLSLGKKILISGFIYTGRDLALPKLICLIESGELTTSGIELQCAVMFHTAVSPAGVGPTSSNKYEIESTIPALSKAGVKIHLGKGRLSPETVKALDDHNSIYAVLPPVTALLESKIIERRVVAFPELGMEALHQLRVEGFPCIVAAAHGKSIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU85</accession>
    <name>D6SU85_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871559.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32865">
        <property type="protein sequence ID" value="EFI32865"/>
        <property type="gene ID" value="Dthio_PD0173"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011174at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8860" checksum="0AC479B3C3284141" modified="2010-08-10" version="1">MAQIAINDFLKVMPAVRMAPKKTFWTTYDVDADVLYINFKKPSYADDSEMTDDDVIIRYEHGEVIGMTILNASQRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>D6SU99</accession>
    <name>D6SU99_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HRDC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0193"/>
    <dbReference type="EnsemblBacteria" id="EFI32879">
        <property type="protein sequence ID" value="EFI32879"/>
        <property type="gene ID" value="Dthio_PD0193"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029491">
        <property type="entry name" value="Helicase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14493">
        <property type="entry name" value="HTH_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="632"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI32879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="832" mass="93855" checksum="84CFF58C28EF908D" modified="2010-08-10" version="1">MSGVDGMSFEWSTNEALELAEGYVEKTGHHVFLTGKAGTGKTTFLKKLQETSSKRMITTAPTGVAALNAGGVTLHSFFQLPFGPFVPGSEAFERDQQRRFRISREKKNIIQSLDLLVIDEISMVRADLLDAVDAALRRHRRSDKPFGGVQLLMIGDLHQLSPVARSHEWELLQGCYNSVYFFDSHALSRTRFISIELEHIYRQSDDSFIRILNQVRDNRLEPESIQALNTRYDPDFVPDTEQGYITLTSHNKKAENINKCRLEELPGQEYLFSAKISGDFPEQIYPTAASLVLKKGAQVMFVRNDPGPEKLYYNGKIGRITSISRDEIQVLCPGEPEPVKVEPLTWENIKYTINEDTREIQEEVAGSFTQHPLKLAWAITIHKSQGLTFERAIIDVQNVFTHGQVYVALSRCKTMEGMVLGSPLAARGVGMDEAILGFDREIRQNPPGKEHLDQARVAYQQQLLLECFDMGRLESRLQYLLSLFKDNSRLVRITGGCDIKELEGLAGEVIEVSRVFLRELGGIFSPERLPESDSYIQERVRKGSRWFQGRLENLAGPLGDTGVETDNAEVKKRIVNALNNLQKDLAVKLAGIKSCEQGFSSAGYLQAVARAEVEFTPRSRKKPEASEWTESDIAHPELFQALKKWRQAKAREQNLAPYQILHQRVAVQIAVTLPATRAELKKIRGVGEKTIARFGQELLDMVADYRRKHGIEKVVLPEKPGSQSKEQPSKKIQAGDTRQVTLDLFRQGQSPDSIAENRGLTRSTIDTHLAYLIHQQELRIDELLSFELQKSIEQAISEVQGNSLKDIKEKLGDEVNYGQIKMVLAHQGTFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUD6</accession>
    <name>D6SUD6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Dthio_PD0230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871609.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0230"/>
    <dbReference type="EnsemblBacteria" id="EFI32916">
        <property type="protein sequence ID" value="EFI32916"/>
        <property type="gene ID" value="Dthio_PD0230"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="114076at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="209"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="230"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="637" mass="72449" checksum="0FC0ECBAF16AB867" modified="2010-08-10" version="1">MDDNFIKAEEDRLQDVCRIADIYARSRLEKASEFAEEVKQLEEERLKSQSSLEKDRLTREIRQRAPLDPSRFNPAFEYPDAPYLAGLVIKDDDAKIGRRHYLFGKQGLADVRTQAQVVIDWRDARISRLYYEWEEGEEYEEDINGKERTGVIQKKISYGIRQRELLSIRTGREFIEKRNGSWKPEDGENISITRKEESGDHRLTDIISLISPEQFSLITREHEGCFYLTGGAGSGKTTVALHRLSYLLYNYPDRFRPQRCLVVMFNRSLRDYIAQTSKDLLTDRMPVETFHSWADKALKAMGIKVNFSSREGQGLSYIKKSASFFQALCAHIEQQPFPGDYLQDLGMFLKNRSLLQQHLKKSRRLDELVREGENILTGTRKALSFDDAGILLYLAGQRNKESCIPGVLGWYDHVLVDEAQDLSLTELKALSMASSSSRSMTVCADRKQKILDFVDSGGFDAFQLDLKKNNLLSGELSVSYRSTAQIMKLASQVSGYNPGRIAHEGPEPKFHSFPDEQSALQSLRRGMENIVRSEPGGLFAVICRYKKEALTVIKALQGIPGARLQTQEPSFKPGILVTNVHQVKGLEFSGVIIWNPHQKAYPDTPAGRNLLYVALTRAGKKLAVYYYQPLATLLLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUK1</accession>
    <name>D6SUK1_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD0295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871674.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0295"/>
    <dbReference type="EnsemblBacteria" id="EFI32981">
        <property type="protein sequence ID" value="EFI32981"/>
        <property type="gene ID" value="Dthio_PD0295"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088215" evidence="5">
        <location>
            <begin position="26"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI32981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="356" mass="39607" checksum="1FDB1F19E0305444" modified="2010-08-10" version="1">MNRRKFLGAMGVAGLGVAGAGKVLAADDGVTGAAVKDVEGLPDSYAVLFDVTRCIGCRQCEDACNYEQRLPEPDAEFHDTQVFEETRRTDWKTYTVVNQYDDKPPGAGDLYRKIQCMHCLEPACAHSCFVKAFAKRPDGAVTYDPKVCVGCRYCMMACPFNIPAYEYHIALDPLVTKCTFCEHRLKEDREPACVEICPTRAMYFSTREEVLKEARKRIVNNPDKYQSHIYGEHEMGGTNWIYISGEPFEDVGMRMDLGNKAAGEYTSGALGGVPLIASFWPVLLVGAYAISKRREKVAKEERDSFVSQVIAEAGPEAGRRLAERLSRSETLDKAAIEEEVKKALNEAAAKTEREDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUR9</accession>
    <name>D6SUR9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0363"/>
    <dbReference type="EnsemblBacteria" id="EFI33049">
        <property type="protein sequence ID" value="EFI33049"/>
        <property type="gene ID" value="Dthio_PD0363"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1016" mass="115446" checksum="F05B47179F6396F6" modified="2010-08-10" version="1">MNPGSQGMKIQLMPERLPGAAWNPPLILPFRLKDGRQGRGTGEKQVFQATGQCIFDRWLALAVFVILLLGLVGAKPAESLGSSKVVPGDARISHEEAGEMLLELLLQSGKEEHLSKAGQVLERIESTHPDGSLMALYRIRLEAALGNRSKAVSLTEEFVRSQEFDADRFIQVADVLASLGRYRMCREIYTKTLDRLKGEEKRRIRLVYSERLLLWGDYYSGEEIIREELADKKHDPELNLRLARNLVAQQRFEQARKHLQRIVHQGPEKSPAVYFEAWSEAVNVALLQKDFAAAAQAADDFQDWYAGREDILLPGARAYLQKGRLEDAQKLFEKASGHENLKVQALPGLARVEMKRGNPDKAVYFLEKAAALDENNPEPFILLSQTRGKPLQEHVEKVLKEETDPAVLTHLAQALAGQGEFELAAEVYDSALAHDPGFFEAGAGLAEVYGSKGRYSASLEILDMMLEEFPESYKLLLTRARVLAWSRQYAESLEAYDQLYTKNQDNHVVIREAARTAYWGKKADTGDRYYQLISTPAVDEMLLQRLQDLDTSQRQILEQAIAGLEREVSAGSVYAGFEGFFDWFGRHGRDLGRESRREMDELRRSLGYRYVIQKQAELERQSKKLLWNERFAPARRHLQKLVEHEPGNQEARFDLAQACCVLGLGDEEEKAYQELLAIDPLHGQASRALERRKKRSRPGFSGNYSFWSERGRGELARMDRHRLDMGLDVPLRSRHSFRVTGHRYFESPQKHAGTVQASGVSLTGEMVTGPHFTLAGGLTYKSYANDLQTRGSKMERESIDLDDLFLGHLDMMFNLDDYARLTLGYEKRETVANAIALAQGVYTENWEAGLDIYPLRRLELGLSAGYLDYSDDNHGVVYGVSAGYSFTDHPRRFRTILSGEYRDTSRTYQGCSNGQGCNIQADFKHPYWTPEDHWGSSVTFEFTHDLARDFFCGARDHFYQLELSLGTEKDKNHSVEVRGTWSREFENGLGINTQAMWHNSREWDAASLDLGLFYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV02</accession>
    <name>D6SV02_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871852.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0047"/>
    <dbReference type="EnsemblBacteria" id="EFI32758">
        <property type="protein sequence ID" value="EFI32758"/>
        <property type="gene ID" value="Dthio_PD0047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1200174at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="302" mass="33646" checksum="CE2B77912CEBA65B" modified="2010-08-10" version="1">MFKKAERSQSKLRLALIGPSGSGKTFSALLIAQGLGGSIAMLDSERGSGSLYSDMAEYDISELTPPYSPERYIEAIKEAEKAGYEILIIDSLSHAWSGQGGILEFVDKASQAQRNNFAAWREASPKHNALVDTILGANLHIIVTMRSKTAWEVNKDEKTGKTKPVKVGLAPVQRDGLEYEFTCVLELSVDGHIATASKDRTRLFDGRYFTPSTETGEELSQWLQGTAQPQENLLNQVMQQLFKLGLANRYAEYETYIHEKYGSSLENLSSKHLREQLENLQRCEADGKLKKKFQAYLTKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SV34</accession>
    <name>D6SV34_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase_SAM-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000005">
        <property type="protein sequence ID" value="EFI32790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0088"/>
    <dbReference type="EnsemblBacteria" id="EFI32790">
        <property type="protein sequence ID" value="EFI32790"/>
        <property type="gene ID" value="Dthio_PD0088"/>
    </dbReference>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase_SAM-like_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI32790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="70" mass="8134" checksum="8AC47EDB448EE574" modified="2010-08-10" version="1">MNLGSCLHTFFDQYLPRTKGVSSNTILAYRHTFSLFLPFASKTLGRDINSLEIEWELRDRLILDISPAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK28</accession>
    <name>D6SK28_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type II secretion system protein H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">General secretion pathway protein H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD3688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3688"/>
    <dbReference type="EnsemblBacteria" id="EFI36231">
        <property type="protein sequence ID" value="EFI36231"/>
        <property type="gene ID" value="Dthio_PD3688"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022346">
        <property type="entry name" value="T2SS_GspH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12019">
        <property type="entry name" value="GspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="GspH" evidence="12">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI36231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="158" mass="17938" checksum="3E3085F880FC5EC5" modified="2010-08-10" version="1">MPKLNWYQKIMNSDQKKTLRQGSAGLSLIELLVVLAIIAILAGTALVYINTDGYRLRAEANNLKSTLQEARMEAVKRNTRAYINLYVDMYTISLPDQYDKVLASVKLPNELELEFNRNPISFQPLGTSGNYEVVIKNNKQHYSLKVRTAGRIFIEGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>D6SK42</accession>
    <name>D6SK42_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tfp pilus assembly protein FimT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3702"/>
    <dbReference type="EnsemblBacteria" id="EFI36245">
        <property type="protein sequence ID" value="EFI36245"/>
        <property type="gene ID" value="Dthio_PD3702"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4969">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="138" mass="14906" checksum="354C2DEBBBC00664" modified="2010-08-10" version="1">MNLPKPAERSREQGFTLIELLIVVAIIGILAAIAIPQFSAYQDRAKLGVITSDLRACLSESVAADAVGEDLEEHCYIDGDDTTVENPFRDDTGGLENLEEIGGDDGTLTVDTGAHDDIENDVECDFDGRSLRDCVYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKA9</accession>
    <name>D6SKA9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class I peptide chain release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869431.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3776"/>
    <dbReference type="EnsemblBacteria" id="EFI36312">
        <property type="protein sequence ID" value="EFI36312"/>
        <property type="gene ID" value="Dthio_PD3776"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2047548at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI36312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="137" mass="15693" checksum="3967C1E739D2B7EB" modified="2010-08-10" version="1">MKITENLSIKESEIDLQAVRASGPGGQKVNKTASAVQLFFDIKASSLPQIYKERLLNLNDQRITRDGVIVIRAERSRSQAKNKKEALKKLQLLIQQATVEPEPRKPTRPSRSAKQRRLAEKARRSRIKEMRKPVHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKF2</accession>
    <name>D6SKF2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, ATPase, predicted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869474.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3823"/>
    <dbReference type="EnsemblBacteria" id="EFI36355">
        <property type="protein sequence ID" value="EFI36355"/>
        <property type="gene ID" value="Dthio_PD3823"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269079at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="PTHR38149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="552" mass="60206" checksum="91A06D63935B93F3" modified="2010-08-10" version="1">MQKLREILDRIDGRGYKAYKDLQGGYSFGEFRLLVDYVQGDPYAPPSRVRAVVPWETAGLPEHALQGEARKVAARDFLARAFSRAVQGERDIRIDAGKQTVLDRTACLFTPDGVELRFTVTLPARGRTILGRQAARLLMEAVPEAVSAVTVRRLDLKALKLHCDVTQDQQSLRDQLDEMDLAAFLADGSILPRRSGVDDRPLQDAVELSSPDTLQVTLHAPNAGALSGLGIPLGVSLIVGGGFHGKSTLLKAVEAGVYDHIPGDGRERVVSNALALKIRAEDGRVVHSVDLSPFISELPYGKSTRDFSTDLASGSTSQAASLQEALEMGASVLLVDEDTSATNFMIRDQRMQKLVAGDEEPITPFVDRIRELRDGLGISTVLVMGGSGDYFDHADTVIQMHEYKPRDVTASAREIASTWATGRVQEPGSALGRPKPRSLDASRLNPCRKPGKRVIKPDGLDALLFGRYEVDLRALEQLADPSQVRAIGVILARLAENGQVIQDPAARIRRMLENDLPRLAFAPDGDLARPRPLEAMAVLNRLRSAHLRGCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKN4</accession>
    <name>D6SKN4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868378.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2656"/>
    <dbReference type="EnsemblBacteria" id="EFI35245">
        <property type="protein sequence ID" value="EFI35245"/>
        <property type="gene ID" value="Dthio_PD2656"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="329" mass="36192" checksum="1D6B0E1ED8DBEB11" modified="2010-08-10" version="1">MEYKDYYKILGVDKNASQEEITKAYKKLARKYHPDLNPDDSTAEDRFKDVNEAYEVLKDPEKRKHYDALGADWQHGQNFQPPPGYENVHFEFRGDPGAGQGFDMGGFSDFFESIFRGFGGAGQDFRGGGTRGFRGDPFSGGGFSSKGQDAEATLELTLEEAYKGGKKSITLQEQVMGADGMPHVQNKTLSVNVPKGIKDGSKIRLSGQGSPGRGQGAAGDLYLKVRIAPHPYFKVDGNNIIYDLPLAPWEAVLGAKVRVPTLDGDVEMNIPSGMSSGQKMRLKGRGMGRGAAKGDQMVRIMIKVPKNITEEEKDLWQQLSEKSGFNPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKR6</accession>
    <name>D6SKR6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868409.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2690"/>
    <dbReference type="EnsemblBacteria" id="EFI35277">
        <property type="protein sequence ID" value="EFI35277"/>
        <property type="gene ID" value="Dthio_PD2690"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033N7C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1854300at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088093" evidence="2">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="208" mass="23133" checksum="4299E4BE49FA5823" modified="2010-08-10" version="1">MKLIRLKWLLLMAAVLLFFTAGTVHAASYYNMTPPKDDGRYLGWDKNVSGEFDFLKPFTPNLVEFDYHVYFLGALAGHTNQLRTGDTVHFDSTVASVGERRIVNFNDDTMLYDATGGKGSHLLEGNTSGAPGIHFFQADKPVKFTYDGFTKEFDTSWIFVGFNDAWTGDNDYNDMVLAVKAVPIPGAVWLLGSGILGLVALRRRIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKS8</accession>
    <name>D6SKS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General secretion pathway protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD2703</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868421.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2703"/>
    <dbReference type="EnsemblBacteria" id="EFI35289">
        <property type="protein sequence ID" value="EFI35289"/>
        <property type="gene ID" value="Dthio_PD2703"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005628">
        <property type="entry name" value="GspK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038072">
        <property type="entry name" value="GspK_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38831">
        <property type="entry name" value="PTHR38831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03934">
        <property type="entry name" value="T2SSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158544">
        <property type="entry name" value="SSF158544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI35289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="332" mass="37119" checksum="346CE2192901B322" modified="2010-08-10" version="1">MCLYPGFHFRFALKVSAQTREDKGFILIAVLWVSLVLSVVAMNAATSSRLQGIQVQNILEIMEQEHLLYSGLARGKHEYLKYEANRALAENREIWEVIAGEGLDLWHPRFEPYEIRVEDVPLAVQIRDVHGRLNINNVQLYLLEEILGHCGVQGSAEISATANSILDWIDEDDLQRPGGAEKDYYLSLPSPYLPKNAQIQDMRELLLVKGVNRHLLYGTDDHPGLIHFFHVYGEAKSLDINSASPETFVLAGLDADSVQEIVDKRNLEPISRLAQLGEVLPPGVLDEVGRYYTVQGSGQALVSAFILLEDGRQGAKISGLPVHSEQSAWHMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKV4</accession>
    <name>D6SKV4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2730"/>
    <dbReference type="EnsemblBacteria" id="EFI35315">
        <property type="protein sequence ID" value="EFI35315"/>
        <property type="gene ID" value="Dthio_PD2730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="37" mass="4487" checksum="BA15AF5E3A86BBAC" modified="2010-08-10" version="1">MKTAMMQIQKNNFLNLVMYSFYISVIINIFIAEHYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SKX2</accession>
    <name>D6SKX2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868465.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2748"/>
    <dbReference type="EnsemblBacteria" id="EFI35333">
        <property type="protein sequence ID" value="EFI35333"/>
        <property type="gene ID" value="Dthio_PD2748"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1296819at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="219" mass="25498" checksum="5E53E46DCFB313A5" modified="2010-08-10" version="1">MHSLYSFLVGPMVWVSLLILVFGLIGKFIYLTNMAKKRDPWVFNYLQLKYALRSIFVWLIPFATMNMRRNPVMTVVTFAFHICLILVPIFALAHVIKWEEAWGFSWWTLPETAAIIMSFIVLGGLVFFAARRIKLPEARYVTRPQDFLILVVVALPYLTGILAYYQIFDYQTMIILHILSGHLMLIAIPFTWLSHLLLFPMARAYVGSEFQGVRNVKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL22</accession>
    <name>D6SL22_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="5">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asnS</name>
        <name evidence="7" type="ORF">Dthio_PD2799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868515.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2799"/>
    <dbReference type="EnsemblBacteria" id="EFI35383">
        <property type="protein sequence ID" value="EFI35383"/>
        <property type="gene ID" value="Dthio_PD2799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="135"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="459" mass="51882" checksum="9B5CED07DAB121A7" modified="2010-08-10" version="1">MKRTRVKQALNAEAPVEGIMLKGWVRTKRESKGVVFLELNDGSCRTNLQIVVDPGVAGIDSLDGTGTGAAIKVTGNLQASPGKGQKWEVQAEQVELIGSADQESYPLQKKRHSDEFLRGIAHLRPRTNKYGAMNRIRSELSFAVHQYFRERGFYYIHTPIITGSDCEGAGDMFVVTALDPDKAWKSPAEFGRDFFGKKAHLTVSGQLPAESMACALGDVYTFGPTFRAENSNTSKHAAEFWMVEPEVAFADLQDIMEMAQGFVQALTGHVKKYCSQDLELFSRFVDQGLEDRLDSVLSQPFERISYTRALEVLQDCGRTFEYPVQWGLDLQTEHERFLCEEHFHKPLIVHDYPAGIKPFYMRVNDDSSTVAAMDVLLPRVGEIIGGSQREERLEVLDRRIQEAGLSFDEYWWYRDLRRFGSVPHAGFGLGFERLLMFITGVSNIRDVIPFPRTPNMLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SL99</accession>
    <name>D6SL99_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional modulator of MazE/toxin, MazF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868592.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2880"/>
    <dbReference type="EnsemblBacteria" id="EFI35460">
        <property type="protein sequence ID" value="EFI35460"/>
        <property type="gene ID" value="Dthio_PD2880"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="107" mass="12004" checksum="CC5CC52440566FBA" modified="2010-08-10" version="1">MGRGDILPVVQPGTYGKPRPALVIQSDFFGVHPSVTILPITSKLRDAPLFRLRVDPTVQNGLLSVSEVMVDKITTLPSDKLREPFGHLEYEYMREVERLLTVWMGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLG3</accession>
    <name>D6SLG3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 domain protein beta Propeller</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2948"/>
    <dbReference type="EnsemblBacteria" id="EFI35524">
        <property type="protein sequence ID" value="EFI35524"/>
        <property type="gene ID" value="Dthio_PD2948"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088099" evidence="1">
        <location>
            <begin position="21"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="374" mass="41730" checksum="F1B735E52F2068CC" modified="2010-08-10" version="1">MLACALFLLYLSGCIMQMLYGDMPDTLESAPGVYALEGLNSPYDDFNAVAVPPPLKMDSFIVFASNAASKGQAFSLETGRVQITQKPYSSRKKELPPPLIIAGERAGPFAPASESAGNHLGPTPLVSSFVPERPYDEAYNYYLSLGLNPGREPKPWPLRLTLDKESLPWNEKGELSPGGVWMFDSDKDGKRNLYFLDDNNEPRPFFGNEPGADDAYATYDFKRHVLYFSSNRSGRFQIYRFQNPSHDTDFSRWLGDVSLAEKIEPATEFTAQGNTLAPYIEGNLLVFASDRPGGYGGYDLYATRYEDGKWQKPFNMQKIMPPGVELNTKANEFRPSIMTMSLKGYQQLKLLLFSSDRPGGKGGYDLYVTALPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLG5</accession>
    <name>D6SLG5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2950"/>
    <dbReference type="EnsemblBacteria" id="EFI35526">
        <property type="protein sequence ID" value="EFI35526"/>
        <property type="gene ID" value="Dthio_PD2950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="273" mass="30863" checksum="2320D953AB6AFDFB" modified="2010-08-10" version="1">MKYPSSSGRVMLVMTVLSIFLAAVLCLPAGASMPVPVKTVEGLVRGGQITIIEPQRFASNKPLEIVPCSNIPFDPDLFEGRKIRATAGIDLYNGMFTCPTDVVILDKGPQDKACSISRSCLKYHVQSDRKTFTPATLQDEKLSLKLGTFVLGLEKTVNAHDWKRLMEDYIHHEYLQKQHDSILQKNTPQFLYELLFPGIYKMQDLSICCMNYLLNVKTSFQARIDMIQDFEVITSGEYLISYMFTYKDGSCLIYNSIYLEKQEDGFKLTGAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLI6</accession>
    <name>D6SLI6_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868679.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2971"/>
    <dbReference type="EnsemblBacteria" id="EFI35547">
        <property type="protein sequence ID" value="EFI35547"/>
        <property type="gene ID" value="Dthio_PD2971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="107" mass="12576" checksum="C41CD55071FC5D1B" modified="2010-08-10" version="1">MNKASSLLFIITLLFYCVMQTDCHASFHLEKDESFRLTSTAQWYLLDCSEKLSCWPALIDKEQVSSAKLFYQQDRSDRLQKAKRELKEKVEDKSMPNKAEQPIFQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLJ4</accession>
    <name>D6SLJ4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1500</name>
        <name evidence="2" type="ORF">Dthio_PD2981</name>
        <name evidence="3" type="ORF">Dthio_PD3536</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1500"/>
    <dbReference type="EnsemblBacteria" id="EFI34157">
        <property type="protein sequence ID" value="EFI34157"/>
        <property type="gene ID" value="Dthio_PD1500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35555">
        <property type="protein sequence ID" value="EFI35555"/>
        <property type="gene ID" value="Dthio_PD2981"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI36089">
        <property type="protein sequence ID" value="EFI36089"/>
        <property type="gene ID" value="Dthio_PD3536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8563" checksum="B96CB8DE98248405" modified="2010-08-10" version="1">MLAPVSIVRTKGFATVQADNLLALFATQELTLLCLRQAKKAVTARQKKRKKKKDRKEDKIKNIFSFLFQKKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLN4</accession>
    <name>D6SLN4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868724.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3023"/>
    <dbReference type="EnsemblBacteria" id="EFI35595">
        <property type="protein sequence ID" value="EFI35595"/>
        <property type="gene ID" value="Dthio_PD3023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI35595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="8681" checksum="1EF53FEC9FD188FD" modified="2010-08-10" version="1">MQEALQRSTRWWQAREVKRIFPDHQTVVIFNDWRSRFNIGRKRILDTMLAATVTIQGVPKPARGQSPRNLSCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLR2</accession>
    <name>D6SLR2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD3052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868752.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3052"/>
    <dbReference type="EnsemblBacteria" id="EFI35623">
        <property type="protein sequence ID" value="EFI35623"/>
        <property type="gene ID" value="Dthio_PD3052"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="161"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI35623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="335" mass="35672" checksum="FDE68B6AC1124977" modified="2010-08-10" version="1">MSDRVLLDYGSGGKASQRLIREIFLKHLGNPGLNRLDDAALIEDLSGPLAVSTDTFTIFPLFFPGGDIGSLAVHGTVNDVAMLGAEPRYLSCAFLLEEGLDMQDLDRIAASMGRAAADCGVQVITGDTKVVPKGAADKMFINTTGIGMVIADPAPSGSRAEPGDAVLISGTMGDHGLAILTHRQGLKFETDIQSDSQALNSLTTRLIREVGDVHVLRDPTRGGLATTLNEIASQSGCEILLQEDQVPVRREVQGGCSFLGLDPLYLANEGKFICILPEDLASKALEVMRSHPAGRDAALIGYVREGQKGRVVLRTSLGGHRLLDMLEGEQLPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>D6SLT0</accession>
    <name>D6SLT0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c biogenesis protein transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD3070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868770.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3070"/>
    <dbReference type="EnsemblBacteria" id="EFI35641">
        <property type="protein sequence ID" value="EFI35641"/>
        <property type="gene ID" value="Dthio_PD3070"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055204at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="307"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="448" mass="47961" checksum="668AE4A0F7FDD38D" modified="2010-08-10" version="1">MAVSLGYENVYRDPKGFEAWEEEGYPVHSLPAEAPATPLEAEGPGTLEGLALFGTLAAVFAGGLALNLTPCVYPLIPITVSFFGGMGGQGRGRLLIHGGLYILGLATTNSILGVAAALTGGLIGGLLQNPLVLAGIALVLLIFALSMFGFWELRLPASLNQAASRSFGGYFGSLFMGLTIGVVAAPCIGPFVLGLLAWVATMGSPLLGFAVFFTLSLGLGVPLFFLAVFSGKLQSLPRSGEWMIWVRKLLGWILVGMAVYFLKPLLGDPAGTFVMAAVFLAAALHLGVLDKTQAGFRAFVWMKSAVLLVGMTLAVFIAGSYALQGPGVAWDDYSEALLEQAGEENKPVMLDFYADWCAPCRQLENVTFQDQDVVELSREFITIKVDMTRGGVELHERLVAEYEVRGVPTVIFLTPEGQEMEDLRVVDFIPPGEFLGLMHNALQKTEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM07</accession>
    <name>D6SM07_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ORF">Dthio_PD3147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868847.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3147"/>
    <dbReference type="EnsemblBacteria" id="EFI35718">
        <property type="protein sequence ID" value="EFI35718"/>
        <property type="gene ID" value="Dthio_PD3147"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="614"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="800"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="1144" mass="131633" checksum="53C0DDE5A46CB6F8" modified="2010-08-10" version="1">MFVDPSLKEKLLDSGRQSRHIHIHKAGPATQIYLAEYLRRQGHDAVLVLPPNSDVKQYMQLAEIFSRTSMEKDKFWESSWFFLPSPGHSSRPAWGRIWASMFGLMQQKGKAAVLTADSMLNYLPPPDVVRDVFLLLMTGEETNPGDILDKLVEWGYVRVFMVTSPGEVSQRGDILDIYAPGYPHPLRLEFFGNHLESIRTFEPVSQRSIRQLEECLILPVSPSPMEDHLVKQARDKADYLKSTGEISRELRQRLEFKLEEKDPFYPAGLFYSSPGEISEFLPEDAHFFLVDTARLRTSLEEEEWKLKQWAEAEGWPEKLFFQPEVRARTMWHNRRQVVFERLVMGQKSRGVDLGEKEINSFSDIFWKPQDNRRPWPAFLQALKEWKRTANQVILNFNTAKSRDKFLDVIQKEDIELKTSFDPEVRGLYAVVAGTGTGMHMSWNHIYILGEDVLQPGTRQRTGPTGRFKGIARVEDIEPGDMLVHRDYGLGRFGGLERISTDTQASDYLVLYYANDDKLYVPVDRFSLVQKYKGPDGADPALDKLGGANWSKTKNRVRKAIQKIAKDLVDMYAQRKVVKGYSYSPPEELYQEFANTFGFQETPDQEQAIREVMQDMESDEPMDRLVCGDVGFGKTEVAMRAAFRAVQDGKQVALLCPTTVLAEQHYQNFVQRMQDFAINVRMLSRFVPRNRQKIILEGARKGEVDILIGTHRILSQDVILPRLSLMILDEEQRFGVRHKEKLKQYRQNIDVLTLTATPIPRTLQLSVSGIRTLSVIETPPLDRKPVESSIIERDRDFLRHALQRELDRQGQVFWVYNRVQGLESVMEYVQDLMPEARVDMAHGQMPERILEENMHRFWHHEIDILVCTAIIESGLDFPRANTLIVDQAHMFGLGQLYQLRGRVGRSQEQAYAYFIVPSVRELGEKSRKRMQIILDMDYLGAGFQVAMEDLRLRGAGNILGEVQSGQIGKVGLDLFLEMMQEEVGKLKGDTSYGSRDLEINIGFSAYIPEDYIPDAAERLKYYRMLSGGAQQQDFDQLSQELQDLFGKLPEELHNFINVLKIKHALKALGPQKADFMENRLSIEWSAETGELNPEKLVQWIEKNSSIARLVPPSKLEIRLNRDSNVLNFLYELQDIVQDLTDHLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SM56</accession>
    <name>D6SM56_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD3198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868896.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI35767">
        <property type="protein sequence ID" value="EFI35767"/>
        <property type="gene ID" value="Dthio_PD3198"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7YQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="224857at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI35767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="462" mass="51659" checksum="7D1488FF406BAFE8" modified="2010-08-10" version="1">MNQQTQPSPREHHFYVAIAKFLFHHSQHGIVSVRDPIRLKDAGRYGLSPLILYGLTVAGLPIRWMTFTPVDQPRPFRDVLLEAWGNAEGLNGQPDILRVNRHLAAASPELAEEMAKIGVQVEVAGAKEKSLPASLRSAQDSSRWLPRKHDGKDRSLAGSVQDLCRNAQEDHDFFVSGGRILRGVHSREVVDRIQCWLALPARVPVPTVTGGLDWEPGPWLSSWETSLPPDQPRYFNHDGFDGSTWLLTGEMVPEDIDDDDFWTDSDWDNAAEIARNLVACWPNPPAEIAGCAGITLRQLQWFISGKTPLDRHARFDLEALLGIEYDKSMGVYAGVGPYALVAHKPQAIKEIYESISGGGDACSCEIVPRQGPADPSWRYILINTYGEPPSIVMAPRGAKITERLPKLLLNYEGIRAVAPEFYRDVVSTCARACREPAANIREMKDFVKRYIEHWVDCAWLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMC0</accession>
    <name>D6SMC0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD3267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008868960.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3267"/>
    <dbReference type="EnsemblBacteria" id="EFI35831">
        <property type="protein sequence ID" value="EFI35831"/>
        <property type="gene ID" value="Dthio_PD3267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI35831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="267" mass="29808" checksum="10FED5023D8CC70F" modified="2010-08-10" version="1">MTLLSIKNLTKRFGGLLAVDDVSFDVEQGRIVGLIGPNGAGKTTVFNLITGNYIPDEGRIMFDGHSLTGLKTHKIVALGIARTFQTIRLFKNLTVLENVMAGCHCRMNSGILSSMLRIPFQRREERMALARALKELEFVGLKQHMDINAMNLSYGNQRLLEIARALASNPKIIILDEPAGGMNDYETTQLVLLIEKMQKRGLTVLLIEHDMNLVMRICEDIIVLEHGARIAQGTPAEITQDQRVIEAYLGIEEEDEEDEAFEAEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMS7</accession>
    <name>D6SMS7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phospholipase D/Transphosphatidylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Dthio_PD3430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI35988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869116.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3430"/>
    <dbReference type="EnsemblBacteria" id="EFI35988">
        <property type="protein sequence ID" value="EFI35988"/>
        <property type="gene ID" value="Dthio_PD3430"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFI35988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="481" mass="55213" checksum="A36D0860A34306A1" modified="2010-08-10" version="1">MQAVEWVVVGIILFFNFLAAGHALLYKRDPKGAWAWIVTCLLVPTLGPVLYFLLGINRVKTRAKKLKWYWPHWDTDIYPSTQKLAPAEKKVRDFEISPDFHQLAQLSEAISRRPLLQGNRVTPLYNGEQAYPEMLAAINRAQKSIYLVTFIFESNDTGQQFANALSKAVQRGVDVRVLVDGIGEYYSWPRIGKTLKDKGVPFVRFLPPRLYPPSPFINLRYHRKMLIVDSEFGFTGGMNLGDRHLVTKLNNRKRKQDVHFKFSGAVVNQMEEVFMEDWGFCTGDYSKSPRQKVARAHQGEAVCRTITVGPNQDLDKLRILLTGIVSQARKRILIMTPYFLPSQELIVALQTAALKGLEVSVVLPEKNNLPYVHWATRNMLWEILQSGVKVFYQPPPFAHSKLFVADDSYALIGSANMDPRSLRLNFELVVEVYEKRLAGKLARHIRSRIRESHETTLHEVDNRPLPVRTRDSFCWLFSPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMW0</accession>
    <name>D6SMW0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3463"/>
    <dbReference type="EnsemblBacteria" id="EFI36021">
        <property type="protein sequence ID" value="EFI36021"/>
        <property type="gene ID" value="Dthio_PD3463"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1509828at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="209"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="293" mass="34091" checksum="19CC88E0592F4797" modified="2010-08-10" version="1">MTHSMTGYGSASMEKAQWNLNWEIKSVNSRHLDIKWKIPPALFYRQTGWEKILRKYASRGRVEIYLDMRILDPDKLGLEFDHPQAMAMIEELKKFASSTGYEFKPDLNVLLRMQSMWQEKSSSMDEELLSDLETCLEKALQKWNDSRKSEGEQLLMDLQERITRLKSSLAQLEDLAAGNTDQRFQELRSRVDRILGEINVEADQNRLLQELSLMADRLDVSEEITRLRAHLDSMHGLVATSGEMGRKLDFFLQEAFREINTCANKCQNTQMSKIAVDFKTELEKCREQAQNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMX0</accession>
    <name>D6SMX0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD3473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869159.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3473"/>
    <dbReference type="EnsemblBacteria" id="EFI36031">
        <property type="protein sequence ID" value="EFI36031"/>
        <property type="gene ID" value="Dthio_PD3473"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI36031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="92" mass="10361" checksum="5650966F954F34FD" modified="2010-08-10" version="1">MIRSFKHKGLARFFKSGSTAGIQAAHAKRLRLILGRLNAASDIKDMDLPGLQLHKLSGKRDGIWSVTVSGNWRVTFLFENGDAKMVNYEDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SMZ0</accession>
    <name>D6SMZ0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix type 11 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD3494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000001">
        <property type="protein sequence ID" value="EFI36051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869179.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD3494"/>
    <dbReference type="EnsemblBacteria" id="EFI36051">
        <property type="protein sequence ID" value="EFI36051"/>
        <property type="gene ID" value="Dthio_PD3494"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="154"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI36051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="333" mass="38920" checksum="CA80477054705D2E" modified="2010-08-10" version="1">MRGRNIIQLLRAVDLLGRPGGITINQMSEALEVDRRSVYRLLDIIQELGFPIYDENDQPGREKSWKLDADYVLKLPNINLPDIRFTLPEIMALYFLRAESRVYRGTEIENRLESAYAKLNRFVPGGLDDQLSKLKTLFVTTGKLTKDYSGKESLIDSLTRAMLRKRTCVVSYFSFMDDTTKKFRIDPLYFFENNGGLYLFVRVTRFGDIRVLAVERIEHLEELEQEFEYPQDFDPEEKLGQAFDIVYDDPVDLEVWFSADQAKYIKERRFSCLQTSQEHPDGSITLKMKTSGWFDVKKWIMGFGSSAVVLKPEEMRNEIREETRAVLARYDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNB7</accession>
    <name>D6SNB7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Type I secretion system ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869571.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1594"/>
    <dbReference type="EnsemblBacteria" id="EFI34243">
        <property type="protein sequence ID" value="EFI34243"/>
        <property type="gene ID" value="Dthio_PD1594"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030256">
        <property type="term" value="C:type I protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030253">
        <property type="term" value="P:protein secretion by the type I secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010128">
        <property type="entry name" value="ATPase_T1SS_PrtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222:SF0">
        <property type="entry name" value="PTHR24222:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01842">
        <property type="entry name" value="type_I_sec_PrtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="15"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="325"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="540" mass="59865" checksum="13E6AC9F966AAA1C" modified="2010-08-10" version="1">MRKYLVRFLPHLGCAFFFSMFINLLALAYILYLRLLFDKVMDSRSMETLFFLTAAVIGAYVVSGIMEVFRSKLLVRIGVKFDQIVAGRIFGSMLDQSVAAGGEKHTQGLKDLNSIRNFLCGTGIFALFDTPWVPVYLAVIFLFHPLLGYLACAGALLLFLLVVVQEISTSRMQASHSQSAMNTDQFLSSSMRNAQTVYAMGMFPSMSRQWKQYNNQDVYYEDVLAARNGFFQSMAKFIMMGTVVVIMSTGAYLVIIHEATLGTMVASAMFMSRALSPIMMLGNAWRSFVDARLAYNRLNELMAEVHTHDDPQLPEQDSPEKPETCRAEGISLHLAQMPVFQDISFRLSAGEMMAVTGPSGSGKTSLARVLLGVWKPDQGSVFLDDISLQSFDQALLGRKMGYVPQEVELFSGTVAENIARLGEVDSPSVVDAAMQARAHDMILGLPQGYDTRVGEGGIALSGGQKQRIVLARALYKDPWLLVLDEPDSHLDQGGRESMKEVLADLKSKGVFLILISHNNELIKLADKVLDMQQGSMRRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNB8</accession>
    <name>D6SNB8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane fusion protein (MFP) family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Dthio_PD1595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869572.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1595"/>
    <dbReference type="EnsemblBacteria" id="EFI34244">
        <property type="protein sequence ID" value="EFI34244"/>
        <property type="gene ID" value="Dthio_PD1595"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1395473at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010129">
        <property type="entry name" value="T1SS_HlyD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01843">
        <property type="entry name" value="type_I_hlyD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="11">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="192"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI34244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="457" mass="51280" checksum="4D292F6124851A9C" modified="2010-08-10" version="1">MSENKLQRNNNVKAIEGDKGDQKTVNLPTSSRNVIIAGLLFVALFFGGIGVWAATANLEGAVIAQGDIIVETYRQQVQHRDGGIVKDIKVREGYQVEKGDVLITLDGEEVRAQRDMYRARMDSFLARQARLMAEIQNADSIEWPLALLERSHLPDATESMESEEQIFKSRMEAKNSRIELLRAQINTQNSLIHGRERQLQSIEDTISSLEEEIQAKDPLLEGGFIDITEILELQRTLNSNRANKEELTTEIDQAEERIKELELEITDLEKSYAQEAASELGDVRQEIVDLREQMRPAEDAARRLNVTAPKAGVVVNLEVRTEGGVIQGGEPLMEIVPRDTGLIVSAKVDPDKIDDVRKGQDASVMLSAFPRRYTPKVKGVVTYVAADRTEPEQRDEPPYYLTYVQLDQQSLKDAIDDPGKLTPGMPAEVYIQTEAQTVMSYVLSPIIDSMDRAFREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNS8</accession>
    <name>D6SNS8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1760"/>
    <dbReference type="EnsemblBacteria" id="EFI34404">
        <property type="protein sequence ID" value="EFI34404"/>
        <property type="gene ID" value="Dthio_PD1760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="31" mass="3541" checksum="71299131606E1C13" modified="2010-08-10" version="1">MIPPPGLESIIDFLQRISQHVKNVHIRSTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNX0</accession>
    <name>D6SNX0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase FAD/NAD(P)-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869768.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1805"/>
    <dbReference type="EnsemblBacteria" id="EFI34446">
        <property type="protein sequence ID" value="EFI34446"/>
        <property type="gene ID" value="Dthio_PD1805"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="278" mass="30123" checksum="9D8DEABB6BDECD91" modified="2010-08-10" version="1">MGKIIQKRVLIPKRVTEMTIKAPVIASKARPGNFVVLRLSMKGERIPLTIADADPEKGHIVIVYLIMGKTTALLDTMKEGDVILDLCGPLGRPTSIKKQGTVACVGGGTGIAALHHIAKGNFQAGNKVVSVIGARSKDLLLFKPELEKISHEVLVSTDDGSVGHKGVVTEVLEEYLDRDPDVKEVIGVGPVPMMRSVARVAQPYGIRTLVSLNSIMVDGIGMCGSCRVNVGGEIRFACVEGPEFEASQVDFDELMMRLQAFKSQEKESMELFEKKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SNX5</accession>
    <name>D6SNX5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Dthio_PD1810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="7">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869773.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1810"/>
    <dbReference type="EnsemblBacteria" id="EFI34451">
        <property type="protein sequence ID" value="EFI34451"/>
        <property type="gene ID" value="Dthio_PD1810"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1885366at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="9">
        <location>
            <begin position="56"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI34451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="139" mass="15757" checksum="BFFFC91BD592B357" modified="2010-08-10" version="1">MGETIRFGVSLDLDLLSRFDQLCSDKSYQTRSEAIRDLIRNALVQQQWEEESQENVGVLSLVYDHHQSDLVQKLTRIQHDALDLVITSLHVHLDHDNCLEVLILRGPGRDIRQTAQKLSSTKGVKHGNLNMATTGKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP01</accession>
    <name>D6SP01_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869799.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1836"/>
    <dbReference type="EnsemblBacteria" id="EFI34477">
        <property type="protein sequence ID" value="EFI34477"/>
        <property type="gene ID" value="Dthio_PD1836"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1503557at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="152"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="286" mass="30898" checksum="EB1FC3B0132B284F" modified="2010-08-10" version="1">MWIILAFITAVCEAAKDGLCKKSLQSMDVFTIAWVWKVFSLPFILPLIFFTPIPEYLPPEFWTALLVGGGLNILATVLYIRAISTSDLSITLPLLSFTPAFLLFTSPLLVGDIPTPLGYVGVLFIVGGSYLLGVGREATLLSPLRALVSDPGARLMLMVALIWSVAANMDKIGVMATSPFFWAVCIQSFISLGLTVVLFCMRGRLRGKMQANLTPLLLIGLVTGVGFVCQMAAIKIGLVPYVIAIKRTSIVLGVLIGGIYFLEKDMKTRVTATLVMLAGVMLIAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP29</accession>
    <name>D6SP29_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869827.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1864"/>
    <dbReference type="EnsemblBacteria" id="EFI34505">
        <property type="protein sequence ID" value="EFI34505"/>
        <property type="gene ID" value="Dthio_PD1864"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="126" mass="13548" checksum="3E4E38E34D1FACC6" modified="2010-08-10" version="1">MSKTVIHTSKAPQAVGPYSQAVALGSLLFTSGQLPLDPETGDMLQGSIQVRAEQCLRNLQNIAEAGGTSLDRAIKVTVFLTNMADFQAVNQVYAQFFKEPYPARTAFQVAALPLGADIEIEAVFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP38</accession>
    <name>D6SP38_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IstB domain protein ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0463</name>
        <name evidence="3" type="ORF">Dthio_PD1879</name>
        <name evidence="4" type="ORF">Dthio_PD2084</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869835.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0463"/>
    <dbReference type="EnsemblBacteria" id="EFI33143">
        <property type="protein sequence ID" value="EFI33143"/>
        <property type="gene ID" value="Dthio_PD0463"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34514">
        <property type="protein sequence ID" value="EFI34514"/>
        <property type="gene ID" value="Dthio_PD1879"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34711">
        <property type="protein sequence ID" value="EFI34711"/>
        <property type="gene ID" value="Dthio_PD2084"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="104"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="253" mass="29025" checksum="0BEC66A94E5AC729" modified="2010-08-10" version="1">MTNKHQSEVHRLEENLQLLKLTCIKEQYRPAADKAARQNWDHLGYLARLVQAEADARHDRSIQRRIRMARFPGIKTMENFDWTWPTKINRPAIQNLFRLGFMKDKANIIILGGVGLGKSHIATALGYSACLEKHSVLFATTIDVINTLSAAQAAHKLKTELKKYVSPELLILDELGYLPIDKQGADLLFQVISQRYEQKSTILTTNRAFKKWPEVFNNDSTLTSAMLDRLLHHAETILIEGKSYRMKDQVQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP41</accession>
    <name>D6SP41_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid maintenance system killer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869838.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1883"/>
    <dbReference type="EnsemblBacteria" id="EFI34517">
        <property type="protein sequence ID" value="EFI34517"/>
        <property type="gene ID" value="Dthio_PD1883"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="97" mass="11157" checksum="E2AA3D19B70EBDC8" modified="2010-08-10" version="1">MIRSFKDQGTEDIFDGKNSKAARKLCPQHLWILAARKLEQVDSATNLDDLKVPPGNRLEALSGDRYGQYSIRINDQYRVCFKWDNGNADNVEIVDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP60</accession>
    <name>D6SP60_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Dthio_PD1908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869856.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1908"/>
    <dbReference type="EnsemblBacteria" id="EFI34536">
        <property type="protein sequence ID" value="EFI34536"/>
        <property type="gene ID" value="Dthio_PD1908"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1508841at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="198" mass="23011" checksum="E91A825586C15DE2" modified="2010-08-10" version="1">MTAKLNLPRVADFLHEVGMLKRTPRTGYQFLGTGSENVAEHSFRTAVIGYILARMAGADREKTVYMCLFHDIHESRVGDMNYVNRLYNKTNDRSALEDALRGTGLEEEVIPLHEELDQNSTLEAGLAEDADQLDLILNLKEQEDLGNRYATKWLEYAWERVKTEHGRKLAGAIFESDHTAWWFESQDKRWWIERKHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SP98</accession>
    <name>D6SP98_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiamineS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869894.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1946"/>
    <dbReference type="EnsemblBacteria" id="EFI34574">
        <property type="protein sequence ID" value="EFI34574"/>
        <property type="gene ID" value="Dthio_PD1946"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="74" mass="7713" checksum="0583252D4624903F" modified="2010-08-10" version="1">MQIQVTCYATLSPYTPGEGLVNMDPGSTPGDLIKHLGIPMDEVKIIFVNGKSADPSAPLNDQDRVGIFPAVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPE4</accession>
    <name>D6SPE4_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">Dthio_PD1992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869940.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1992"/>
    <dbReference type="EnsemblBacteria" id="EFI34620">
        <property type="protein sequence ID" value="EFI34620"/>
        <property type="gene ID" value="Dthio_PD1992"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1647539at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFI34620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="130" mass="14092" checksum="8E72202A355B8C59" modified="2010-08-10" version="1">MVSDTSAIIAILTGEPEADVLTRVIAESPDVMMSSFSVLETGIVLEARKGEAGGRELDLFLQRARVRVMPLDSEQVRIAREAWRRFGKGRHPAGLNIGDCCAYALAKSTGAPLLFKGHDFSKTDILVAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPE8</accession>
    <name>D6SPE8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD1996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008869944.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1996"/>
    <dbReference type="EnsemblBacteria" id="EFI34624">
        <property type="protein sequence ID" value="EFI34624"/>
        <property type="gene ID" value="Dthio_PD1996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI34624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="253" mass="27762" checksum="F9B68C852FA601B1" modified="2010-08-10" version="1">MKKETACLQVQGLEKHFGVGDQRQQVLQDISLEVHQGEILALLGASGCGKTTLLNILAGFVSPDAGSVYVQGRLSTVPGPHKAVVFQEDALFPWLSVMENVEFGLKFQGRTRKEQRDTALKMLGLVGLEDKQAMLPAQLSGGMRQRVALARVLALSPMLMLMDEPFAALDALTREEMHGLLLSLHAEFSQTIIFVTHDVIEAVTLADRVLVMGGRKVLSTVDISALRPRKPDTDQFMEDLRILRAALKQAYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPM7</accession>
    <name>D6SPM7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD2075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870023.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2075"/>
    <dbReference type="EnsemblBacteria" id="EFI34703">
        <property type="protein sequence ID" value="EFI34703"/>
        <property type="gene ID" value="Dthio_PD2075"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="751256at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="460"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="601"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI34703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="736" mass="80727" checksum="37CB501FB4D3E025" modified="2010-08-10" version="1">MTSLFQELIHDLRPGTLIPALCIGLIIGLMGIVLAVSFAAMIFSGEVSHLAVRGVGLTLTGGLLACIAVALTSSFKSSISLPQDAPAAIFSGGAALMAAQTISGTGDVFMTIVAGLIISSIFTGFFLFIIACFSLVNFFRYIPYPVIGGFLAGSGWILSSSSLEVMLGSRPDLLDPWYLFTPSFLMLWLPGTALAVLLFVLLRRFSHFALLPATLVLGAVLFHVILLFSGFSLDQAREAGLLFDTLESGALWPVFTWQEMSGINWQAVFAQLPVLLTIPFIVLMGLILNVSGVELASNREIDMNREVMSNSLGNFLCGLSGSPAGYSSLSLSMMGFKTGAYTRLAGLTAAAVMALTLAWGGFLIALFPKAVLGGALMLLGLLFLWDWVIEARKKMVWTDYLIVLAILVMIAWLGFFQGVVLGILLSVVLFVIRFSQVPVLKNSFSGPSVQSPRSRPLPHKRILMDQGDRIKVFELSGYLFFGSVNSLVQDIDSKIAQQDYSDDLYAIIDFSDTSGVDISSVSAFARLLNRLDRSGVRVVFTGASTWFLYQLKNHTARMQDQEHFISFNDFNQGLQWCEDRIIKQYLDAVNQGSQDHIRSRLFADVADEMLKNLEELESIENVVENIKDYSIVMHLEKGEALIQPGQKLKGVYLIQLGGVVKTDPEGQEELVQQEYGPGDVVNLKGLFEEVESKHLYRASSASRVHYFSSEDIGLLQEKDPDMAARFYSILLRSSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPR4</accession>
    <name>D6SPR4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 conserved barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2113"/>
    <dbReference type="EnsemblBacteria" id="EFI34740">
        <property type="protein sequence ID" value="EFI34740"/>
        <property type="gene ID" value="Dthio_PD2113"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="159" mass="17661" checksum="760DD865440CCC79" modified="2010-08-10" version="1">MINKSAIFSFSHIFKENILNTKKCIASFMLLTLLLWTNAWAGEETGVESQVLIQTSKSWDGEMLPDYPEGTPEIKVLRITVPPGTTLPLHKHPVINVGVLLKGELKVVTEEDETLILQSGEAIVEVVDKWHYGVNEADEPAEIIVFYAGTSDKPVTVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6SPX3</accession>
    <name>D6SPX3_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD2180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870115.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2180"/>
    <dbReference type="EnsemblBacteria" id="EFI34799">
        <property type="protein sequence ID" value="EFI34799"/>
        <property type="gene ID" value="Dthio_PD2180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="225" mass="25321" checksum="A013072400627D00" modified="2010-08-10" version="1">MKKPTKKSTIPALVLGGMLAYGTIGDKVNSEYQNTTQQNAQVETAQTDYKASALENLTQALAPNKAFAQTNQNYQRPDDATLKEWMNQPVEETLAGTNYTKVNDDNYQREVKQADQPVMVLFYANQGEGSTGLAALTKTLHEKFPEIKLCAYKLTDSESISRPEFERLQQNYPLESAPALLFYEEKDFGSGTEFLAQFKGGISTLDLLKDEIDRYYEVTPKYLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ18</accession>
    <name>D6SQ18_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2235"/>
    <dbReference type="EnsemblBacteria" id="EFI34844">
        <property type="protein sequence ID" value="EFI34844"/>
        <property type="gene ID" value="Dthio_PD2235"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="PTHR44366"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="241" mass="27725" checksum="B49FB51428F44387" modified="2010-08-10" version="1">MLLVFLAGCAHTGADRMSLHQAELRLDLAERYLIEDEPRPALEQLQQVKEASPDNPRLYFNMGLAHTSMEDWDRAARDFEKALELKPDYGEAWNNLGQVRKAQGRTQEARQAYEAALEIEEYMTPEFAYYNLASLFQEEGDLERALEYAVNSVEKNRRFVPGYDLAGSLYQELDLYDEALRIFERGAQAMPGNARLSLAYAEELVRAGRDSEAITWFEHVIEQNDDSQEAQMARDYLEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ26</accession>
    <name>D6SQ26_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">Dthio_PD2243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870166.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2243"/>
    <dbReference type="EnsemblBacteria" id="EFI34852">
        <property type="protein sequence ID" value="EFI34852"/>
        <property type="gene ID" value="Dthio_PD2243"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="185" mass="20634" checksum="6D9FE9A93A588CA6" modified="2010-08-10" version="1">MLSTTDFRKGLKIEIENEPYEIVDFMHVKPGKGGAFVRTKLRNLLTGGMLDQTFRSGEKVAKPDLESREMQYLYHDGTAYVFMDMGSYEQLMVDDESMGEKGGFLKDGQTVKALIYRGNPIDIEIPAAVILEVAETEPGMKGDTVTGGTKPARLETGIAVNVPLFINEGERIKVDTRTKEYMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ40</accession>
    <name>D6SQ40_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870180.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI34866">
        <property type="protein sequence ID" value="EFI34866"/>
        <property type="gene ID" value="Dthio_PD2257"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034530">
        <property type="entry name" value="HpnP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00303">
        <property type="entry name" value="hopanoid_C2-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="159"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="492" mass="56712" checksum="7B3C2CD8448F6725" modified="2010-08-10" version="1">MRTLMVYPQYPDTFWSFKHALRFISKKAAYPPTGLLTVAAMLPGEWEKRVVDLNVESLSDSDIEWADMVLVSAMLVQDKSAREVISRSKEKGKTVVAGGPAFTSQPESYPEVDHLILNEAETTLPLFLKDLEMGKPERIYTSQERPALDRTPVPEWSLIDMRKYASMAIQYSRGCPYQCEFCDIVIMNGRRPRTKSPEQMINEVETLYNAGWRGSLFIVDDNFIGNKRKVKKMLASLKEWQAEHDYPFVLFTEASVELADDQELMDLMRQSNFNKVFLGLETPNKESLQECGKNQNSSRDLVQAVETIHQNGMLVMGGFIVGFDNDNESIFESQIRFIQQSGVVTAMVGLLGALPRTRLWERLQKEGRLLYTPTGENTDGSLNFIPRMGTETLLAGYRDIVSTIYSPRYYYQRIETFLKSYRPTSRSRINRHDIIALWRSIWRIGIFSRSAPWFWKVLIKTALTKTRALPEVVELSIFGHHFQRIYKRCRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQ96</accession>
    <name>D6SQ96_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD2313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870236.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2313"/>
    <dbReference type="EnsemblBacteria" id="EFI34922">
        <property type="protein sequence ID" value="EFI34922"/>
        <property type="gene ID" value="Dthio_PD2313"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1975893at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007446">
        <property type="entry name" value="PilP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04351">
        <property type="entry name" value="PilP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003087916" evidence="1">
        <location>
            <begin position="28"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="164" mass="18412" checksum="07131A9709859417" modified="2010-08-10" version="1">MPIKNRGVSKTVFSIAFIFVFVFPVPAQDNDRSSPDPDWMQVEAPQYNPEGLQDPFVPFVMPEEPPDALPALERLRPLTPLERVELGQLRLVGTMQSPEQEIMAMVEMPDGKGFMLHKGTRIGPNQGEVLEIHPDRVLVREYIQGAYGIEESLSTLKLRPGDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQE5</accession>
    <name>D6SQE5_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD2363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2363"/>
    <dbReference type="EnsemblBacteria" id="EFI34971">
        <property type="protein sequence ID" value="EFI34971"/>
        <property type="gene ID" value="Dthio_PD2363"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="176"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="400" mass="45482" checksum="7B58102E71E0055F" modified="2010-08-10" version="1">MQKTPDLNDLVGIEHSKLGFFQELRQKIEELKEANRKSEERRREIAAILDGITDVMMVLSENLRIISVNHVFHEFFDEPRPEGKFCYQLFRGEDYPCPECPAFRSMATDSVCRDTAIFKLGGRNLQFEMVASPLKNKEWEENRVLIFKRDVTLEKEYQAKYYQVEKMATIGMLAAGVAHEVNNPMAAINGFAEGLRRRIPRIEKSVDPELAQDFREYTDIILKECKRCQKIIQTLLTFSRPKHFSFSPINLNRVVNETLRLVDHSLRKRKGLKVKLDLQDGLPLINADESQLKQVILNLLVNAKDAIQDKGLITIKTSAFEHENEVCLCVEDDGCGIDPDKMDKLFEPFFTTKPVGKGIGIGLASCYNIVESHGGEISVTSEPGKGSRFTVCLPLNPSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQK2</accession>
    <name>D6SQK2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD2422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870342.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2422"/>
    <dbReference type="EnsemblBacteria" id="EFI35028">
        <property type="protein sequence ID" value="EFI35028"/>
        <property type="gene ID" value="Dthio_PD2422"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088155" evidence="1">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="43"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI35028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="21410" checksum="BF67CB2409331A97" modified="2010-08-10" version="1">MKGIKTIILFLALFLASPGLSPADEGAIYDPGELKPIDSEIKVEEGDEAIDFTLPAVGGEEISLSQYRGEKNVMLSFVPAAWTPVCSDQWPGYNIARHFFDDNDTIILGITTDNVPSQYSWIKSMGGLWFPVLSDFWPHGEVAEKYGILRGDGTAERATIIVDKEGIIRFAHVEDINRRPPLEMLVEAMEKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQL9</accession>
    <name>D6SQL9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartate transcarbamylase</fullName>
            <shortName evidence="6">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrB</name>
        <name evidence="10" type="ORF">Dthio_PD2439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ASO3-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870359.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2439"/>
    <dbReference type="EnsemblBacteria" id="EFI35045">
        <property type="protein sequence ID" value="EFI35045"/>
        <property type="gene ID" value="Dthio_PD2439"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="156"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFI35045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="315" mass="34638" checksum="15ED80E8EF9F4261" modified="2010-08-10" version="1">MNWIHKDLLDIESLSPDEVRHIFDTSARFMEINSRSIKKVPILKGKSVVLFFAEPSTRTKTSFDMAAKRLSADSFSLAATGSSLSKGEGLKDTVLTLQAMNPDAIVLRHSLSGAAGFIASHLDCSVLNAGDGWHAHPTQALLDGFTLFQHWQDFQDKKILILGDIAHSRVARSDVQLLSMLGCRIRVCAPRTLLPRGIHNWPVEVYSSLDKACRGMDAIISLRLQLERQEAGLLPDLREYSSRFCLQPGHVQKAAPGVKIMHPGPINRGVEISSGLADCADSLILEQVGSGVAVRMALLYLYLARSKPDQEITEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQQ9</accession>
    <name>D6SQQ9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">Dthio_PD2479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870399.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2479"/>
    <dbReference type="EnsemblBacteria" id="EFI35085">
        <property type="protein sequence ID" value="EFI35085"/>
        <property type="gene ID" value="Dthio_PD2479"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1680292at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI35085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="157" mass="16810" checksum="EFB8F5F94F615853" modified="2010-08-10" version="1">MLHIKTIEGRLDARGLKIALVACRFNDFIVDKLIGGAVDYLVRHGMEKENLTLYRVPGAFEMPVLVKRLAGKKDIDGIVCLGAVIRGATPHFDYVASEATKGIAQSSIESGMPVGFGLLTTDSLEQAIERAGSKAGNKGVEAAAAVLELIRVMEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SQX4</accession>
    <name>D6SQX4_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Dthio_PD2546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000002">
        <property type="protein sequence ID" value="EFI35150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870464.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD2546"/>
    <dbReference type="EnsemblBacteria" id="EFI35150">
        <property type="protein sequence ID" value="EFI35150"/>
        <property type="gene ID" value="Dthio_PD2546"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1149839at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF539">
        <property type="entry name" value="PTHR24031:SF539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="10">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="223"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFI35150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="721" mass="81181" checksum="4BE27002F5F50C57" modified="2010-08-10" version="1">MQYYAHTLENKPQREWQLLEVHLRQVAEMTAKHARVFSASDWGYILGRLHDIGKYRQEFQDKLEKQSSRRVDHKGVGARLAWEYLGQPGKLVSYCIAGHHGGLPNYGHSQTDTSTSLMDLLQQAGVLPDHAPDPVSDISLPSLPFQPRSAFQLAFFTRMLFSALVDADFLDTERFMEPEKYAARNPGPALADLLQPLNAKLAGFSNEGRINLLRREILERCRENASLEPGLFTLTVPTGGGKTLASMAFALEHSQKYGHRRIIYVIPYTSIIEQNAQVFREIFPPDSIIEHHSNFDERSLPEEADQFGPGLRHRLACENWGAPVVVTTNVQFFESLYASKPSRCRKLHNLAGSVIILDEAQMLPVKYLNPCLRALEELAENYQASIVLCTATQPALRKRDDFKHGLDGVREIAPEPKRMHREFLRTRLKDAGRLDLEEVANLIRDKEQVLCVVNTRARAGNLFDLVQNEPGARHLSALMCPAHRSLELKKIREVLMDGAPCRVVSTQLVEAGVDVSFPEVIREMAGLDSMAQAAGRCNREGELDDLGKVTVFTPSEGLAPAFSQAAGSAHSTLRHYGHDPFAPDAVEYFFSETYWLQAQRLDEKQILDEFRAPAPKWAFRDVAKRFNLIENFMSPVIISFNEEAENLIERLRFAVAAGGTLRKLQHYIVQIYTHELAALDEAGAIEYVDGQYPVLIDKELYSAKQGLKVPREPKTPDGFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>D6SR29</accession>
    <name>D6SR29_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33145">
        <property type="protein sequence ID" value="EFI33145"/>
        <property type="gene ID" value="Dthio_PD0466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="8858" checksum="55678C4CC7B5E828" modified="2010-08-10" version="1">MLAPVSVVGTKGFATVQADNLLALFTAQELSLLCLRQAKKAVTARQKKRKKKKDRKEDKIKNIFFFSLLEEDTRIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRC6</accession>
    <name>D6SRC6_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="8">FGAM synthase</shortName>
            <ecNumber evidence="8">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="8">FGAR amidotransferase II</shortName>
            <shortName evidence="8">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purL</name>
        <name evidence="12" type="ORF">Dthio_PD0568</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="8"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870600.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0568"/>
    <dbReference type="EnsemblBacteria" id="EFI33242">
        <property type="protein sequence ID" value="EFI33242"/>
        <property type="gene ID" value="Dthio_PD0568"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26038at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="11">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="9">
        <location>
            <begin position="301"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="10">
        <location>
            <begin position="442"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="10">
        <location>
            <begin position="830"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFI33242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="994" mass="110333" checksum="8D50731EED4C6319" modified="2010-08-10" version="1">MALKLELDLLEHVRDVQGEGIARRINQHLGISVDSVRMITCYTISGVQKSQKQEILDRHILSDPVLHKPAFNPLAADFDWIIEVGFKPGVTDNEGRTAARALEQALTEPGPDIRVYTSRQYLINARLDREQATRIARDLLANELIHRYEIKDHQEWSSRPGFTPVEAKVTGIPSDEVSAVTLENLSDEDLMQLSREMVLALSLEEMHTIRDYYRGEQVRTIRQDLGLPLDPTDVELECLAQTWSEHCKHKIFNARIDYHNAETGSRSTINSLFDTYIASSTRDIRRQKKDQDFCRSVFKDNAGVIAFDQDLDVCIKVETHNSPSALDPYGGALTGIVGVNRDPMGTGMGADLLCNTDVFCFASPFYDQPLPPRLLHPRRVMEGVREGVEHGGNKSGIPTVNGAVVFEPRYLGKPLVFCGTVGSIPARINHKPGYEKKAMPSDLIVMTGGRIGKDGIHGATFSSEELHSGSPATAVQIGDPITQRKMYDFIIRARDLGLYNAITDNGAGGLSSSVGEMAEDTGGCDLDLSLAPLKYDGLRPWEILLSEAQERMTLAVPPDRLQEFMDLAREMDVEATVLGSFNDQGSFMVRYEDRVVGCLDMHFLHHGLSRMHLKAVWNRPDLPCHISADLDESRAGDLLLDMLSRLNICSREYIIRQYDHEVQGGSVIKPLVGVNRDGPGDAAVIRPVLSSEKGLVISNGICPKYSDLDTYWMMANAIDEAVRNNVATGGDMRHMAGVDNFCWCDPVQSPKTPDGHYKLAQLVRANQALAHFCRGYGVPCISGKDSMKNDYMDQDLKISIPPTVLFSVISVIQDINLCLSSDFKSPDQDIYVLGLTRDELGGSELSYQLDMQGGQVPQVDMLSSRLRYHTFHQAASKRLVSACHDLSDGGLGVALAEMAIGGRIGASVDISLVPARPRDLPWWKILYSESAGRFIVTAPIQNRQELQDMFKGQFLARIGCTTGGSELEINMQDRTLCRLDVSRMARAWQKTLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRC9</accession>
    <name>D6SRC9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870603.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0571"/>
    <dbReference type="EnsemblBacteria" id="EFI33245">
        <property type="protein sequence ID" value="EFI33245"/>
        <property type="gene ID" value="Dthio_PD0571"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033IDE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891838at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="113" mass="13018" checksum="D2C0951926A5323D" modified="2010-08-10" version="1">MSEEINLELKKPLDKMTAKELRQLCIDKIPQISGASGMSKEELLSSIKEVLGMSQEEGGKSGAYKDQIKSLKARMKELQEQRLNLPKSRRRERDVLRKKIHDLRKNTRRLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRG5</accession>
    <name>D6SRG5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870639.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0607"/>
    <dbReference type="EnsemblBacteria" id="EFI33281">
        <property type="protein sequence ID" value="EFI33281"/>
        <property type="gene ID" value="Dthio_PD0607"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="193" mass="22344" checksum="386C24DB64E5BD20" modified="2010-08-10" version="1">MAKNKKKKILEVAAQLFASQGFDNTTTLQIARETRVTEPLLYYHFKGKEEIFTYILAEVFQKYAEHIDELPKNTQTEFDKIANLIRLHSHIAEEHPQNARLILSNCPGKLMQKQHACRDILEKQQQMVSSYIQDCLESGNAKKEFDAHPVEQTALILLCLANEFMRMKIMRKKDSQPDTQGTIEFCRKSLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRG7</accession>
    <name>D6SRG7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Dthio_PD0609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870641.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0609"/>
    <dbReference type="EnsemblBacteria" id="EFI33283">
        <property type="protein sequence ID" value="EFI33283"/>
        <property type="gene ID" value="Dthio_PD0609"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="170"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="310" mass="34624" checksum="73C43A36B77723F7" modified="2010-08-10" version="1">MSSDETKEKRSVLIVDDQPDNIHALGKLIKDEYRIMAATSGARALEIAESDNPPDLILLDVMMPEMDGYEVCRRLKRNEKTNSIPVIFVTAMDSAEDEETGFNLGAVDYISKPFKPTIVRARIKNQMNLKIKTDMLEKLSMQDGLTEIPNRRFFEENLAREWSRCMRNGLPLSQLIMDIDNFKPYNDNYGHGAGDDCLKKVANVIKNTLSRPTDLAARYGGEEFVVLLPETHAAGAVHVAEELRAAVQGLGITHEHSPTASVVTISVGTSTHSAESPMKNKEQLLQLADEALYQAKESGRNRVQSSYLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRL0</accession>
    <name>D6SRL0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0653"/>
    <dbReference type="EnsemblBacteria" id="EFI33326">
        <property type="protein sequence ID" value="EFI33326"/>
        <property type="gene ID" value="Dthio_PD0653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="126" mass="14545" checksum="1BA59E9213BD0B60" modified="2010-08-10" version="1">MNITIFGKPEKNFTIEETEVHRFSSVILCLFLCESLSSLWCQTFDDNGHKDHLECKSELDLLLKPCLSRLWRDKSSSNTLRSQKTRKFSRKDAKYAKLKTRSRCIVQNRATVLDKAAFLSDLCLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRL2</accession>
    <name>D6SRL2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger SWIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD0655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0655"/>
    <dbReference type="EnsemblBacteria" id="EFI33328">
        <property type="protein sequence ID" value="EFI33328"/>
        <property type="gene ID" value="Dthio_PD0655"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="273" mass="31603" checksum="D27DE3E93A546ACB" modified="2010-08-10" version="1">MLDFDELTIRDQVADSSVIFQRGRTLYEDGAYMCMEALPEEGRYEYQVDGNYGDYSTVVVVGDNGLDCSCDCPYPGPGCKHVVAVALDVLDRVQDWQDKSSTQEPEKLSDYLTPEEIREKAMEDRRNRARKEEFKLIRGDMIKGDHLLETEQGRQYRVTLHDPANGLGHCSCPDFNTNQLGTCKHLLALKEQLLRKKDLEQGREELFPFVDVYWDSAQGLPRLFCERPPGEIQEIAPVLEKYFDQEGIFRFENLGRMLDFMDAVRERKQVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRL7</accession>
    <name>D6SRL7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870691.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0661"/>
    <dbReference type="EnsemblBacteria" id="EFI33333">
        <property type="protein sequence ID" value="EFI33333"/>
        <property type="gene ID" value="Dthio_PD0661"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YNH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="86" mass="10145" checksum="B0A141574FDB7824" modified="2010-08-10" version="1">MTKIDDMLEKIRWNPKDVRYSDLCKICDHFFGEPRQKKSSHRIYKTPWEGDPRVNIQNSKGKAKTYQVKQVLLAIEKLEGNHGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRN7</accession>
    <name>D6SRN7_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870711.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0681"/>
    <dbReference type="EnsemblBacteria" id="EFI33353">
        <property type="protein sequence ID" value="EFI33353"/>
        <property type="gene ID" value="Dthio_PD0681"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011898">
        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
        <property type="entry name" value="PTHR43724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="94" mass="10330" checksum="4CEF2EC00754BF93" modified="2010-08-10" version="1">MANLALCAWEKLELGTAITEPGNAAQLKTGDWKTLHPVTDQEKCIKCGMCQVFCPEFCIHEDSEGFYPADLYYCKGCGICANECPKKAITMTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>D6SRS2</accession>
    <name>D6SRS2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870746.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0719"/>
    <dbReference type="EnsemblBacteria" id="EFI33388">
        <property type="protein sequence ID" value="EFI33388"/>
        <property type="gene ID" value="Dthio_PD0719"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="96" mass="10993" checksum="6F8BBA482E489784" modified="2010-08-10" version="1">MNRNNIFNTIKKYREKSGDEFGILRIGVFGSLAKGQENSASDVDVVVDLNKQDLFRIIGIKQDLEDILVLKVDVISYRPGMNKFLKERIDQEAVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS04</accession>
    <name>D6SS04_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870822.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0804"/>
    <dbReference type="EnsemblBacteria" id="EFI33470">
        <property type="protein sequence ID" value="EFI33470"/>
        <property type="gene ID" value="Dthio_PD0804"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50343V4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935528at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021675">
        <property type="entry name" value="DUF3261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11659">
        <property type="entry name" value="DUF3261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="217" mass="24342" checksum="2C64F081C022F974" modified="2010-08-10" version="1">MVKVVLLLFFLGGCASQFSPPEEYVAVSPDTGLSCSLDIWSGAGGAVGLRHTVFLEIREEHRVLQGLMLVDRDRGQIRIAGLTEMGMKLFDLSVREQELESHYLSSALGERREPLAQLVASSVRRIFLYSRPASEAKVYMGPHSVLVHSSFQGEPVLQECTQADGRLTQVSCPRENWQVDYTEYQDIDGMTLPGRIIYNDERAGFRLVLVLHEVQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS11</accession>
    <name>D6SS11_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="4" type="ORF">Dthio_PD0811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870829.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0811"/>
    <dbReference type="EnsemblBacteria" id="EFI33477">
        <property type="protein sequence ID" value="EFI33477"/>
        <property type="gene ID" value="Dthio_PD0811"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFI33477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="9619" checksum="CB31F1027B3D5F56" modified="2010-08-10" version="1">MTQQQIIETVNRALSEEFELEPADMSPEAHLYNDLGLDSLDAVDMVIVLENAFGCKLRDEKAIQNIRTMGDLYAFIEEKKKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS71</accession>
    <name>D6SS71_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">Dthio_PD0871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870887.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0871"/>
    <dbReference type="EnsemblBacteria" id="EFI33537">
        <property type="protein sequence ID" value="EFI33537"/>
        <property type="gene ID" value="Dthio_PD0871"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI33537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="143" mass="16369" checksum="67C8D9EBF82BE0B6" modified="2010-08-10" version="1">MKINVELSAPLVPVLCLSRREVRDIIRRILENLDCRESSLNLVITDDSRMQHLNSAFLFCPGPTNVLAFEEESRHESGFLGEVFISAQAVIRESILYSQPIFEHFVRLLAHGIEHLAGFEHGPEMEDRTLHLQRTIKAEEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS86</accession>
    <name>D6SS86_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, BadM/Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870902.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0886"/>
    <dbReference type="EnsemblBacteria" id="EFI33552">
        <property type="protein sequence ID" value="EFI33552"/>
        <property type="gene ID" value="Dthio_PD0886"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="143" mass="15904" checksum="CCFA4B4762AD04C0" modified="2010-08-10" version="1">MMLTRGGEYAVRCVLYLAACTTPGQVAPKKEVAQAMQIPESFMAKVAQTLSRAGIIQITQGARGGYRLLKDPSRLSLLQVVEAVDGEIFLNQCIMSPESCRRSPSCGVHRVWETARQRLRQTLDETDFATLAREEVCSQQQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>D6SS87</accession>
    <name>D6SS87_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome bd ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Dthio_PD0887</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870903.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0887"/>
    <dbReference type="EnsemblBacteria" id="EFI33553">
        <property type="protein sequence ID" value="EFI33553"/>
        <property type="gene ID" value="Dthio_PD0887"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271551at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFI33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="445" mass="49646" checksum="A9B71623A15A8BC1" modified="2010-08-10" version="1">MDVLLLSRLQFAMTTFVHFIFVPLTLGLSLLVAYMETKFIRTGDETYRRMAKFWGKLFLINFALGAVTGIALEFQFGTNWSRYSAYVGDVFGSLLAIEATMAFFLESTFLGVWIFGWKKLPPKLHNASIWLVALAANLSAFWIIMANGWMQNPVGHLMGDGRAELASFIQLVSNEFAWQQFIHVLSASYVLSGFFVLGISAWHLARGSHVDFFRKSFRIAAPFTLVFALVVVVHGHHHGSTVAKYQPEKLAAMESHWETRTNAPQYLLVIPDPANEGNRLELLPIPGGLSMLAYHSFDAEVTGLKDFPEEDRPPVWATFMSFRTMVALGMLFPVLAAWAWIRRKDPASSPRMLRLLPWIIPLPYVAVQLGWIVAEMGRQPWIVYGMMRTEEAFSPGITTGQVAGSLAGFFAIYGLLVALCIFLLSKYGRKGPAPAESGEETAGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSI2</accession>
    <name>D6SSI2_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Dthio_PD0984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008870997.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0984"/>
    <dbReference type="EnsemblBacteria" id="EFI33648">
        <property type="protein sequence ID" value="EFI33648"/>
        <property type="gene ID" value="Dthio_PD0984"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="193"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="302" mass="33877" checksum="EDD736699CD37AAF" modified="2010-08-10" version="1">MIKVFCCPQMHDLARKICKASEACESGEISWNYFQDGFPNLMVHDAIGLRNSHVVFLASMDSPAEIFSQLSVIYELPRLAVKSLKVIMPYFPTGTMERVDEEGEIATAATLARMLSLVPGTMTGPVQIIIYDIHALQERFYFSDQVVPRLETAVPLLLERIQGMPDVAVAFPDEGAWKRFGRMFEGYPLITAHKVRDKDGRRVIIREGEPRGRNVIVVDDLVMTGGTLIKCRQALEEAGAKSVSAYVTHGVFPQKSWERFIDQGFERFWLTDSCPETARQVDGTDPFEVLSLAGDISRKLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>D6SSK9</accession>
    <name>D6SSK9_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RsbRD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD1011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1011"/>
    <dbReference type="EnsemblBacteria" id="EFI33675">
        <property type="protein sequence ID" value="EFI33675"/>
        <property type="gene ID" value="Dthio_PD1011"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RXU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025751">
        <property type="entry name" value="RsbRD_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14361">
        <property type="entry name" value="RsbRD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RsbRD_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="169" mass="20147" checksum="6DB4845990217351" modified="2010-08-10" version="1">MSLDASIKQHKSQILNLWLKKFTDTYPDESARFFKNSPGQFNNPVGYTFRVNMEKILDEFFQDNDQEKMRQYLDGITRIRAVQGFSPTEALCFLPMLRETIWEVCGREIESNNQYGDWVDLLTRLDRLTYLAFDIYMSCREQLWKQRSEMFHNRTHKLLERAIAKNAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST20</accession>
    <name>D6ST20_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1175"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0711">Selenium</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003088194" evidence="1">
        <location>
            <begin position="26"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="58"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="163" mass="19119" checksum="A20E104228AF2211" modified="2010-08-10" version="1">MKFSRITSFVISVLALMAFSNPLHAAEEKVWWEDAEKKAEEQGYRLIDTSELHRLYKEEAEMTVIDNRYEYEFKHSTILPGAVNVPFRPAERSSLDSGKKEQLISATGEDKERRIIFYCRSFRUVQSGIAARWAVRLGYENIYRYKAGIMAWEEKYPEMVETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>D6ST73</accession>
    <name>D6ST73_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proton-translocating NADH-quinone oxidoreductase, chain L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Dthio_PD1228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ASO3-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871238.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1228"/>
    <dbReference type="EnsemblBacteria" id="EFI33889">
        <property type="protein sequence ID" value="EFI33889"/>
        <property type="gene ID" value="Dthio_PD1228"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="132"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFI33889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="699" mass="77072" checksum="7A68AB331E89F05D" modified="2010-08-10" version="1">MDIQLAWLCLIFPFIGVLVTPFLARISTSVMNFGAVFFSFLAAVCALMLFPLLFSAEALPLESQLVWLHTPITVSFGVLVDPLSIIVANVVAVISFFIMVYCVGYMKGDPGIMRFWMLMNAFIGSMLLLVLANNLIIIFIGWKLVGLCSYGLIGFYYRDEKKYWIGGPEPYSFDTPSACGVKAFIVTSVGDMLMLGGILIMYFYAGTFNVLELYQTAPEWIPEMAATPGMIILVSILLIAGPVGKSAQFPLHEWLPEAMSGPGPVSALIHAATMVKSGVFLIARFIPIFYYGYWTAGVDEAMYFFLIVAWIGAITAFLAASQGLVALELKKILAYSTVSQIGYMMLALGVAGFSQDLLVKGYAAGTFHLMSHAMFKACLFLCAGTVIHAAHSIYINDMGALRKFLPYTWLFMGLATLSLIGVPPLPGFWSKEAVLLATLESQHIVLFLIVLVSVIFTAFYSTRYFGMMFHGKQSRHIKQELKKPHNHVHEGYFPQTFACGVLAAGIVIFGLMGMRVEYALYGLFETQLVQDLAHSTVLSVPSFDKTLIMVLSIGSVLIGVIPAYMFYIARKWDADAVYENSRVVQLVHAFLWNRWYINAFYNWLFVKGVMGAARAVAEKVEIAVDTAINRLTPSGVFGLSGISVWFDRKGIDGFLDGMAYHVQNSAGGTLSRLQNGRIQDYLALAVIIALLVCGIIWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6STC9</accession>
    <name>D6STC9_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI33945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI33945">
        <property type="protein sequence ID" value="EFI33945"/>
        <property type="gene ID" value="Dthio_PD1284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI33945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="84" mass="10003" checksum="E7EC5C21E6885024" modified="2010-08-10" version="1">MQTHNTIEQRFLQEIKGLDQDEVEKIIKMVRFMKSEILKAKQKNTRPDLMKYAGFLNDLSPDENELFNQAVQRKSMFKGRELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>D6STL2</accession>
    <name>D6STL2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mn2+dependent serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD1367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871377.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1367"/>
    <dbReference type="EnsemblBacteria" id="EFI34028">
        <property type="protein sequence ID" value="EFI34028"/>
        <property type="gene ID" value="Dthio_PD1367"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1874360at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="281" mass="32942" checksum="62B33944BF752C07" modified="2010-08-10" version="1">MKVDESLFSALPYRPEILREKNLYAMGHPDLVPILKKLAEEPDLDLPGQSQVIKEHPNLIVQTSLLTDDNFPWPRQVIKQFRWRGIQNYLASPLKKSKAVKSYLAACHLLKHGLGTPLPLGAVEVRRWGFVSGSAYLCESVDDFVDLKQYRKALPDGKIYMEKVLQMLAGYTLRMHDTGMMHKDLNLRNFLLAGPRGDYSLYLVDLNRAWCRKSVPLWFRAMDLSRLDLKHWYPQFYKYYCQGRFHEKTILKMAAWTRTWRRQWRRMAVGSSDLRHKIGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6STP8</accession>
    <name>D6STP8_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Dthio_PD1403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000003">
        <property type="protein sequence ID" value="EFI34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871413.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD1403"/>
    <dbReference type="EnsemblBacteria" id="EFI34064">
        <property type="protein sequence ID" value="EFI34064"/>
        <property type="gene ID" value="Dthio_PD1403"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFI34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="125" mass="13864" checksum="9C8615FC55140F4D" modified="2010-08-10" version="1">MAVIAVLDDVQDATILVQRILGRKGHTVHPFTEEDDFFAHLRENHVDLAILDIKLKKMSGVDVLEEAKKITPGLRVLMLTGYPTLETAQRALQLGADEYLVKPIDKHELEEKVAQVLADEAKGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUA2</accession>
    <name>D6SUA2_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Dthio_PD0196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EFI32882">
        <property type="protein sequence ID" value="EFI32882"/>
        <property type="gene ID" value="Dthio_PD0196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFI32882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="120" mass="13422" checksum="810D7603A0C3745E" modified="2010-08-10" version="1">MKIDYDSKYDLMNIEFLPGEPIVDSLEINGVVIDYGKDGKIVSIEIIDASERTQKGPLGKLDCNSSGGRYANLPVFQAGNALLGIFYSSKPCVRSTREKPEGFPCLRRFFWHGQLRCTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUL8</accession>
    <name>D6SUL8_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="8" type="ORF">Dthio_PD0312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI32998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871691.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0312"/>
    <dbReference type="EnsemblBacteria" id="EFI32998">
        <property type="protein sequence ID" value="EFI32998"/>
        <property type="gene ID" value="Dthio_PD0312"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="7">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="7">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFI32998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="178" mass="19520" checksum="ADABA8FF48984031" modified="2010-08-10" version="1">MSRIGIEPIKIPQGVEITQHSSMIDVKGPKGQLSVDLDPRISINIEGQTLQVQKADDSIKAREQWGLRRTLINNAVQGVHQGFKKSLDVIGVGYKVDLQGNTLVLNVGYSHPVHIELPGGVEGSVEKNRITLSGIDKQLVGETAAKIRRVRPPEPYKGKGIRYENEEVKQKAGKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUN3</accession>
    <name>D6SUN3_9DELT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="6" type="ORF">Dthio_PD0327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ASO3-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871706.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0327"/>
    <dbReference type="EnsemblBacteria" id="EFI33013">
        <property type="protein sequence ID" value="EFI33013"/>
        <property type="gene ID" value="Dthio_PD0327"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFI33013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="210" mass="23078" checksum="AF2DB7320794F71F" modified="2010-08-10" version="1">MKHTIGLIGKKLGMTSVFSDDGKFIPVTVIQAGPCPVIQKKDQDKDGYSAIQIGYDSMPGHKLNKPVRGHQAKAGKGFFRKLTEFSPENVEEFEPGQELNVEIFKPGDRIKLTGTSKGKGFAGVMKRWNFRGLPRTHGHEKVHRSPGAIGQCADPGKVFKGKKMPGRMGNKTVSYKNAEIISVRTQDNVILVKGQVPGPRNGYVVLHKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUU5</accession>
    <name>D6SUU5_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Dthio_PD0389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0389"/>
    <dbReference type="EnsemblBacteria" id="EFI33075">
        <property type="protein sequence ID" value="EFI33075"/>
        <property type="gene ID" value="Dthio_PD0389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFI33075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="77" mass="9021" checksum="D4AD2BEE6A888B56" modified="2010-08-10" version="1">MDRAGWLVSGEDKKRGLGDGCKQAGKTTERRFSHYNFPRLKKFQKQPNTLEETEEILIFIISWLVCILIESAYRLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>D6SUV0</accession>
    <name>D6SUV0_9DELT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TrkA-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Dthio_PD0394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Desulfonatronospira thiodismutans ASO3-1</name>
        <dbReference type="NCBI Taxonomy" id="555779"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfovibrionales</taxon>
            <taxon>Desulfohalobiaceae</taxon>
            <taxon>Desulfonatronospira</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-05" db="EMBL/GenBank/DDBJ databases">
            <title>The draft genome of Desulfonatronospira thiodismutans ASO3-1.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Cheng J.-F."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Chertkov O."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Land M.L."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Muyzer G."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ASO3-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACJN02000004">
        <property type="protein sequence ID" value="EFI33080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008871773.1">
        <property type="nucleotide sequence ID" value="NZ_ACJN02000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="555779.Dthio_PD0394"/>
    <dbReference type="EnsemblBacteria" id="EFI33080">
        <property type="protein sequence ID" value="EFI33080"/>
        <property type="gene ID" value="Dthio_PD0394"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1671192at2"/>
    <dbReference type="Proteomes" id="UP000005496">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="4">
        <location>
            <begin position="115"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="RyR" evidence="3">
        <location>
            <begin position="533"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFI33080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000005496"/>
        </source>
    </evidence>
    <sequence length="622" mass="71939" checksum="508B3328E79C9C3D" modified="2010-08-10" version="1">MEDKKINLNKKIGQFVDLRHACFALILFILFYILALLGLMRNDIVFLDAAYKALQMIVMNADLHEARLDMNIPLQISRFALPLFAAFSIIAVLFKIAGQQICYFRHSISPRKNVFLGAGRMAFGIIQSLDEDTPIIAMDINIDKKYAISIRERPNSILLHGDARDINTLKRLKLNKVDTIYIFTGDDNLDLDITSKVISLIPEKQRERPRLIVDIEDKSLRRIAGHIPNFQEYREKDGGIIWFSAKSLAARKLLIEYPPITISSQKYKKKVHKKVHIGIVGLGDFAKETVLQLVRHCVFFEDAPLLISLFDNDESQFQKFIARHPVLNFDQADAAYGGRSPIADILFYHYDTNSTSPGIIRRALSEREDIPFSRIYVTGDNDYSCVDASYRISQCLQVLRQNADVVCCLPELNNNTILIKYHSWETYTKIHFYQIMKDMLGRQEKYPGEISDNIGMMIHAAYGVINNKKDSEISEIELSKKYKELKNEEWIKLTDFQQYSSRHSGDHIFVKLREIGFSLEPCSNASTLPSSEVKIIELEKAIDENMENLKKNEHKRFCMERLIDDWLFDEKKDKPMQINNTIVKYEKLDEAEHDKDVAIIKALPHIVKMYIETNQFKLVRQQ</sequence>
</entry>
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</copyright>
</uniprot>